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Journal articles on the topic 'Dendritic arborization'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Schaefer, Andreas T., Matthew E. Larkum, Bert Sakmann, and Arnd Roth. "Coincidence Detection in Pyramidal Neurons Is Tuned by Their Dendritic Branching Pattern." Journal of Neurophysiology 89, no. 6 (2003): 3143–54. http://dx.doi.org/10.1152/jn.00046.2003.

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Neurons display a variety of complex dendritic morphologies even within the same class. We examined the relationship between dendritic arborization and the coupling between somatic and dendritic action potential (AP) initiation sites in layer 5 (L5) neocortical pyramidal neurons. Coupling was defined as the relative reduction in threshold for initiation of a dendritic calcium AP due to a coincident back-propagating AP. Simulations based on reconstructions of biocytin-filled cells showed that addition of oblique branches of the main apical dendrite in close proximity to the soma ( d < 140 μm

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Chen, Chiung-Ya, Chia-Wen Lin, Chiung-Ying Chang, Si-Tse Jiang, and Yi-Ping Hsueh. "Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology." Journal of Cell Biology 193, no. 4 (2011): 769–84. http://dx.doi.org/10.1083/jcb.201008050.

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Dendritic arborization is a critical neuronal differentiation process. Here, we demonstrate that syndecan-2 (Sdc2), a synaptic heparan sulfate proteoglycan that triggers dendritic filopodia and spine formation, regulates dendritic arborization in cultured hippocampal neurons. This process is controlled by sterile α and TIR motif–containing 1 protein (Sarm1), a negative regulator of Toll-like receptor 3 (TLR3) in innate immunity signaling. We show that Sarm1 interacts with and receives signal from Sdc2 and controls dendritic arborization through the MKK4–JNK pathway. In Sarm1 knockdown mice, de

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Mishra, Archana, Boris Knerr, Sónia Paixão, Edgar R. Kramer, and Rüdiger Klein. "The Protein Dendrite Arborization and Synapse Maturation 1 (Dasm-1) Is Dispensable for Dendrite Arborization." Molecular and Cellular Biology 28, no. 8 (2008): 2782–91. http://dx.doi.org/10.1128/mcb.02102-07.

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ABSTRACT The development of a highly branched dendritic tree is essential for the establishment of functional neuronal connections. The evolutionarily conserved immunoglobulin superfamily member, the protein dendrite arborization and synapse maturation 1 (Dasm-1) is thought to play a critical role in dendrite formation of dissociated hippocampal neurons. RNA interference-mediated Dasm-1 knockdown was previously shown to impair dendrite, but not axonal, outgrowth and branching (S. H. Shi, D. N. Cox, D. Wang, L. Y. Jan, and Y. N. Jan, Proc. Natl. Acad. Sci. USA 101:13341-13345, 2004). Here, we r

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Fujishima, Kazuto, Junko Kurisu, Midori Yamada та Mineko Kengaku. "βIII spectrin controls the planarity of Purkinje cell dendrites by modulating perpendicular axon-dendrite interactions". Development 147, № 24 (2020): dev194530. http://dx.doi.org/10.1242/dev.194530.

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ABSTRACTThe mechanism underlying the geometrical patterning of axon and dendrite wiring remains elusive, despite its crucial importance in the formation of functional neural circuits. The cerebellar Purkinje cell (PC) arborizes a typical planar dendrite, which forms an orthogonal network with granule cell (GC) axons. By using electrospun nanofiber substrates, we reproduce the perpendicular contacts between PC dendrites and GC axons in culture. In the model system, PC dendrites show a preference to grow perpendicularly to aligned GC axons, which presumably contribute to the planar dendrite arbo

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Troilo, David, Meijuan Xiong, Justin C. Crowley, and Barbara L. Finlay. "Factors controlling the dendritic arborization of retinal ganglion cells." Visual Neuroscience 13, no. 4 (1996): 721–33. http://dx.doi.org/10.1017/s0952523800008609.

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AbstractThe effects of changing retinal ganglion cell (RGC) density and availability of presynaptic sites on the development of RGC dendritic arbor in the developing chick retina were contrasted. Visual form deprivation was used to induce ocular enlargement and expanded retinal area resulting in a 20–30% decrease in RGC density. In these retinas, RGC dendritic arbors increased in a compensatory manner to maintain the inner nuclear layer to RGC convergence ratio in a way that is consistent with simple stretching; RGC dendritic arbors become larger with increased branch lengths, but without chan

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Jan, Yuh-Nung, and Lily Yeh Jan. "Branching out: mechanisms of dendritic arborization." Nature Reviews Neuroscience 11, no. 5 (2010): 316–28. http://dx.doi.org/10.1038/nrn2836.

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Kong, Jiming, Vivian W. Y. Tung, John Aghajanian, and Zuoshang Xu. "Antagonistic Roles of Neurofilament Subunits NF-H and NF-M Against NF-L in Shaping Dendritic Arborization in Spinal Motor Neurons." Journal of Cell Biology 140, no. 5 (1998): 1167–76. http://dx.doi.org/10.1083/jcb.140.5.1167.

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Dendrites play important roles in neuronal function. However, the cellular mechanism for the growth and maintenance of dendritic arborization is unclear. Neurofilaments (NFs), a major component of the neuronal cytoskeleton, are composed of three polypeptide subunits, NF-H, NF-M, and NF-L, and are abundant in large dendritic trees. By overexpressing each of the three NF subunits in transgenic mice, we altered subunit composition and found that increasing NF-H and/or NF-M inhibited dendritic arborization, whereas increasing NF-L alleviated this inhibition. Examination of cytoskeletal organizatio

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Keil, Kimberly P., Sunjay Sethi, and Pamela J. Lein. "Sex-Dependent Effects of 2,2′,3,5′,6-Pentachlorobiphenyl on Dendritic Arborization of Primary Mouse Neurons." Toxicological Sciences 168, no. 1 (2018): 95–109. http://dx.doi.org/10.1093/toxsci/kfy277.

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AbstractEarly life exposures to environmental contaminants are implicated in the pathogenesis of many neurodevelopmental disorders (NDDs). These disorders often display sex biases, but whether environmental neurotoxicants act in a sex-dependent manner to modify neurodevelopment is largely unknown. Since altered dendritic morphology is associated with many NDDs, we tested the hypothesis that male and female primary mouse neurons are differentially susceptible to the dendrite-promoting activity of 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95). Hippocampal and cortical neuron-glia co-cultures were exp

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Keeler, Austin B., Dietmar Schreiner та Joshua A. Weiner. "Protein Kinase C Phosphorylation of a γ-Protocadherin C-terminal Lipid Binding Domain Regulates Focal Adhesion Kinase Inhibition and Dendrite Arborization". Journal of Biological Chemistry 290, № 34 (2015): 20674–86. http://dx.doi.org/10.1074/jbc.m115.642306.

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The γ-protocadherins (γ-Pcdhs) are a family of 22 adhesion molecules with multiple critical developmental functions, including the proper formation of dendritic arbors by forebrain neurons. The γ-Pcdhs bind to and inhibit focal adhesion kinase (FAK) via a constant C-terminal cytoplasmic domain shared by all 22 proteins. In cortical neurons lacking the γ-Pcdhs, aberrantly high activity of FAK and of PKC disrupts dendrite arborization. Little is known, however, about how γ-Pcdh function is regulated by other factors. Here we show that PKC phosphorylates a serine residue situated within a phospho

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SCHIERWAGEN, ANDREAS K., and JAAP VAN PELT. "SHAPING NEURONAL DENDRITES: INTERPLAY OF TOPOLOGICAL AND METRICAL PARAMETERS." Journal of Biological Systems 03, no. 04 (1995): 1193–200. http://dx.doi.org/10.1142/s0218339095001076.

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The functional role of a neuron within a network is influenced by the geometry of its dendrites. In the present study we have used a new model of dendritic arborization to analyze how metrical and topological parameters interact to shape a certain dendritic tree. One of the specific questions addressed is how to change topological variability in a systematic way while preserving the metrical features. The second problem concerns the effect of topology on the relationship between dendritic size and the distribution of dendritic surface area with radial distance from soma. The simulation results

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Grueber, Wesley B., Lily Y. Jan, and Yuh Nung Jan. "Tiling of the Drosophila epidermis by multidendritic sensory neurons." Development 129, no. 12 (2002): 2867–78. http://dx.doi.org/10.1242/dev.129.12.2867.

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Insect dendritic arborization (da) neurons provide an opportunity to examine how diverse dendrite morphologies and dendritic territories are established during development. We have examined the morphologies of Drosophila da neurons by using the MARCM (mosaic analysis with a repressible cell marker) system. We show that each of the 15 neurons per abdominal hemisegment spread dendrites to characteristic regions of the epidermis. We place these neurons into four distinct morphological classes distinguished primarily by their dendrite branching complexities. Some class assignments correlate with k

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Jan, Yuh-Nung, and Lily Yeh Jan. "Erratum: Branching out: mechanisms of dendritic arborization." Nature Reviews Neuroscience 11, no. 6 (2010): 449. http://dx.doi.org/10.1038/nrn2854.

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Xiao, Lan. "Different Influences of Lipofection and Electrotransfection on In Vitro Gene Delivery to Primary Cultured Cortex Neurons." March 2016 3;19, no. 3;3 (2016): 189–96. http://dx.doi.org/10.36076/ppj/2019.19.189.

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Background: Many pain states are linked to central nervous system (CNS) diseases involving the dysfunction of dendritic arborization, making restoration a promising therapeutic strategy. Transfection of primary cortex neurons offers the possibility to study mechanisms which are important for the restoration of proper arborization. Its progress is, however, limited at present due to the lack of suitable gene transfer techniques. Objective: To obtain better insight into the transfection potential of currently used techniques, 2 non-viral transfection methods, lipofection and gene electrotransfer

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Amthor, Franklin R., Norberto M. Grzywacz, and David K. Merwine. "Extra-receptive-field motion facilitation in on-off directionally selective ganglion cells of the rabbit retina." Visual Neuroscience 13, no. 2 (1996): 303–9. http://dx.doi.org/10.1017/s0952523800007549.

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AbstractThe excitatory receptive-field centers of On-Off directionally selective (DS) ganglioncells of the rabbit retina correspond closely to the lateral extent of their dendritic arborizations. Some investigators have hypothesized from this that theories for directionalselectivity that entail a lateral spread of excitation from outside the ganglion cell dendritic tree, such as from starburst amacrine cells, are therefore untenable. We show herethat significant motion facilitation is conducted from well outside the classical excitatory receptive-field center (and, therefore, dendritic arboriz

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Alizzi, Rebecca A., Derek Xu, Conrad M. Tenenbaum, Wei Wang, and Elizabeth R. Gavis. "The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth." PLOS Genetics 16, no. 12 (2020): e1009235. http://dx.doi.org/10.1371/journal.pgen.1009235.

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Dendritic arbor morphology influences how neurons receive and integrate extracellular signals. We show that the ELAV/Hu family RNA-binding protein Found in neurons (Fne) is required for space-filling dendrite growth to generate highly branched arbors of Drosophila larval class IV dendritic arborization neurons. Dendrites of fne mutant neurons are shorter and more dynamic than in wild-type, leading to decreased arbor coverage. These defects result from both a decrease in stable microtubules and loss of dendrite-substrate interactions within the arbor. Identification of transcripts encoding cyto

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Li, Haimin, Gang Chen, Bing Zhou, and Shumin Duan. "Actin Filament Assembly by Myristoylated, Alanine-rich C Kinase Substrate–Phosphatidylinositol-4,5-diphosphate Signaling Is Critical for Dendrite Branching." Molecular Biology of the Cell 19, no. 11 (2008): 4804–13. http://dx.doi.org/10.1091/mbc.e08-03-0294.

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Dendrites undergo extensive growth and branching at early stages, but relatively little is known about the molecular mechanisms underlying these processes. Here, we show that increasing the level of myristoylated, alanine-rich C kinase substrate (MARCKS), a prominent substrate of protein kinase C and a phosphatidylinositol-4,5-diphosphate [PI(4,5)P2] sequestration protein highly expressed in the brain, enhanced branching and growth of dendrites both in vitro and in vivo. Conversely, knockdown of endogenous MARCKS by RNA interference reduced dendritic arborization. Results from expression of di

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Tsuyama, Taiichi, Asako Tsubouchi, Tadao Usui, Hiromi Imamura та Tadashi Uemura. "Mitochondrial dysfunction induces dendritic loss via eIF2α phosphorylation". Journal of Cell Biology 216, № 3 (2017): 815–34. http://dx.doi.org/10.1083/jcb.201604065.

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Mitochondria are key contributors to the etiology of diseases associated with neuromuscular defects or neurodegeneration. How changes in cellular metabolism specifically impact neuronal intracellular processes and cause neuropathological events is still unclear. We here dissect the molecular mechanism by which mitochondrial dysfunction induced by Prel aberrant function mediates selective dendritic loss in Drosophila melanogaster class IV dendritic arborization neurons. Using in vivo ATP imaging, we found that neuronal cellular ATP levels during development are not correlated with the progressi

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Narayanan, Rishikesh, Anusha Narayan, and Sumantra Chattarji. "A Probabilistic Framework for Region-Specific Remodeling of Dendrites in Three-Dimensional Neuronal Reconstructions." Neural Computation 17, no. 1 (2005): 75–96. http://dx.doi.org/10.1162/0899766052530811.

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Dendritic arborization is an important determinant of single-neuron function as well as the circuitry among neurons. Dendritic trees undergo remodeling during development, aging, and many pathological conditions, with many of the morphological changes being confined to certain regions of the dendritic tree. In order to analyze the functional consequences of such region-specific dendritic remodeling, it is essential to develop techniques that can systematically manipulate three-dimensional reconstructions of neurons. Hence, in this study, we develop an algorithm that uses statistics from precis

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Yong, Hyo-Jeong, Jong-Ik Hwang, and Jae-Young Seong. "Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1." Cells 10, no. 8 (2021): 1868. http://dx.doi.org/10.3390/cells10081868.

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Neurogenesis and functional brain activity require complex associations of inherently programmed secretory elements that are regulated precisely and temporally. Family with sequence similarity 19 A1 (FAM19A1) is a secreted protein primarily expressed in subsets of terminally differentiated neuronal precursor cells and fully mature neurons in specific brain substructures. Several recent studies have demonstrated the importance of FAM19A1 in brain physiology; however, additional information is needed to support its role in neuronal maturation and function. In this study, dendritic spine morpholo

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Watanabe, Kaori, Yuki Furumizo, Tadao Usui, Yukako Hattori, and Tadashi Uemura. "Nutrient-dependent increased dendritic arborization of somatosensory neurons." Genes to Cells 22, no. 1 (2016): 105–14. http://dx.doi.org/10.1111/gtc.12451.

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Milošević, Nebojša T., and Dušan Ristanović. "Fractality of dendritic arborization of spinal cord neurons." Neuroscience Letters 396, no. 3 (2006): 172–76. http://dx.doi.org/10.1016/j.neulet.2005.11.031.

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Czöndör, Katalin, Kornelia Ellwanger, Yannick F. Fuchs, et al. "Protein Kinase D Controls the Integrity of Golgi Apparatus and the Maintenance of Dendritic Arborization in Hippocampal Neurons." Molecular Biology of the Cell 20, no. 7 (2009): 2108–20. http://dx.doi.org/10.1091/mbc.e08-09-0957.

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Protein kinase D (PKD) is known to participate in various cellular functions, including secretory vesicle fission from the Golgi and plasma membrane-directed transport. Here, we report on expression and function of PKD in hippocampal neurons. Expression of an enhanced green fluorescent protein (EGFP)-tagged PKD activity reporter in mouse embryonal hippocampal neurons revealed high endogenous PKD activity at the Golgi complex and in the dendrites, whereas PKD activity was excluded from the axon in parallel with axonal maturation. Expression of fluorescently tagged wild-type PKD1 and constitutiv

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Mohandas Rao, K. G., S. Muddanna Rao, and S. Gurumadhva Rao. "Enhancement of Amygdaloid Neuronal Dendritic Arborization by Fresh Leaf Juice ofCentella asiatica(Linn) during Growth Spurt Period in Rats." Evidence-Based Complementary and Alternative Medicine 6, no. 2 (2009): 203–10. http://dx.doi.org/10.1093/ecam/nem079.

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Centella asiatica(CeA) is a creeping herb, growing in moist places in India and other Asian Countries. Ayurvedic system of medicine, an alternate system of medicine in India, uses leaves of CeA for memory enhancement. Here, we have investigated the role of CeA fresh leaf juice treatment during growth spurt period of rats on dendritic morphology of amygdaloid neurons, one of the regions concerned with learning and memory. The present study was conducted on neonatal rat pups. The rat pups (7-days-old) were fed with 2, 4 and 6 ml/kg body of fresh leaf juice of CeA for 2, 4 and 6 weeks. After the

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Gan, Kathlyn J., and Thomas C. Südhof. "Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment." Proceedings of the National Academy of Sciences 116, no. 25 (2019): 12524–33. http://dx.doi.org/10.1073/pnas.1902672116.

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Aging drives a progressive decline in cognition and decreases synapse numbers and synaptic function in the brain, thereby increasing the risk for neurodegenerative disease. Pioneering studies showed that introduction of blood from young mice into aged mice reversed age-associated cognitive impairments and increased synaptic connectivity in brain, suggesting that young blood contains specific factors that remediate age-associated decreases in brain function. However, whether such factors in blood from young animals act directly on neurons to enhance synaptic connectivity, or whether they act by

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Cowan, R. L., and C. J. Wilson. "Spontaneous firing patterns and axonal projections of single corticostriatal neurons in the rat medial agranular cortex." Journal of Neurophysiology 71, no. 1 (1994): 17–32. http://dx.doi.org/10.1152/jn.1994.71.1.17.

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1. Spontaneous fluctuations of membrane potential, patterns of spontaneous firing, dendritic branching patterns, and intracortical and striatal axonal arborizations were compared for two types of corticostriatal neurons in the medial agranular cortex of urethan-anesthetized rats: 1) pyramidal tract (PT) cells identified by antidromic activation from the medullary pyramid and 2) crossed corticostriatal (CST) neurons identified by antidromic activation from the contralateral neostriatum. The ipsilateral corticostriatal projections of intracellularly stained PT neurons as well as contralateral co

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Mohandas Rao, K. G., S. Muddanna Rao, and S. Gurumadhva Rao. "Centella asiatica (L.) Leaf Extract Treatment During the Growth Spurt Period Enhances Hippocampal CA3 Neuronal Dendritic Arborization in Rats." Evidence-Based Complementary and Alternative Medicine 3, no. 3 (2006): 349–57. http://dx.doi.org/10.1093/ecam/nel024.

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Centella asiatica(CeA) is a creeping plant growing in damp places in India and other Asian countries. The leaves of CeA are used for memory enhancement in the Ayurvedic system of medicine, an alternative system of medicine in India. In this study, we have investigated the effect during the rat growth spurt period of CeA fresh leaf extract treatment on the dendritic morphology of hippocampal CA3 neurons, one of the regions of the brain concerned with learning and memory. Neonatal rat pups (7 days old) were fed with 2, 4 or 6 ml kg−1 body weight of fresh leaf extract of CeA for 2, 4 or 6 weeks.

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MANGRUM, WELLS I., JOHN E. DOWLING, and ETHAN D. COHEN. "A morphological classification of ganglion cells in the zebrafish retina." Visual Neuroscience 19, no. 6 (2002): 767–79. http://dx.doi.org/10.1017/s0952523802196076.

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We examined the distribution and morphological types of ganglion cells in the retina of the zebrafish, a model vertebrate genetic organism. Using cresyl violet and methylene blue staining, a prominent central area was observed in the ventral temporal retina. The density of ganglion cell layer neurons averaged from ∼12,000/mm2 in the dorsal-nasal retina to a peak of ∼37,000/mm2 in the ventral-temporal retina. Individual zebrafish ganglion cells were labeled by backfilling with DiI through the optic nerve followed by reconstruction using confocal microscopy. The dendritic stratification and bran

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P., Devi N., and J. K. Mukkadan. "EFFECT OF ROTATORY VESTIBULAR STIMULATION ON LEARNING AND MEMORY IN RATS-STANDARDIZATION OF A NOVEL METHOD." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 1 (2016): 145. http://dx.doi.org/10.22159/ijpps.2017v9i1.14940.

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<p><strong>Objective</strong>:<strong> </strong>To find out the effect of rotatory vestibular stimulation in cognition in rats through examining the behavioural patterns, the alterations in dendritic arborization and changes in AChE activity.</p><p><strong>Methods</strong>:<strong> </strong>Rotatory vestibular stimulation was provided in a rotatory vestibular apparatus at a rate of 50 rpm for 5 min, for 30 d for rats. 0.3 mg/kg of physostigmine also administered to rats of another group as a standard drug. No rotatory vestibular

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Avery, Adam W., David D. Thomas та Thomas S. Hays. "β-III-spectrin spinocerebellar ataxia type 5 mutation reveals a dominant cytoskeletal mechanism that underlies dendritic arborization". Proceedings of the National Academy of Sciences 114, № 44 (2017): E9376—E9385. http://dx.doi.org/10.1073/pnas.1707108114.

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A spinocerebellar ataxia type 5 (SCA5) L253P mutation in the actin-binding domain (ABD) of β-III-spectrin causes high-affinity actin binding and decreased thermal stability in vitro. Here we show in mammalian cells, at physiological temperature, that the mutant ABD retains high-affinity actin binding. Significantly, we provide evidence that the mutation alters the mobility and recruitment of β-III-spectrin in mammalian cells, pointing to a potential disease mechanism. To explore this mechanism, we developed a Drosophila SCA5 model in which an equivalent mutant Drosophila β-spectrin is expresse

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Schwartz, P. M., R. L. Levy, P. R. Borghesani, and R. A. Segal. "Purkinje cell dendritic arborization is defective in BDNF −/− mice." Molecular Psychiatry 3, no. 2 (1998): 119–20. http://dx.doi.org/10.1038/sj.mp.4000367.

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Shrestha, Brikha R., and Wesley B. Grueber. "Neuronal Morphogenesis: Worms Get an EFF in Dendritic Arborization." Current Biology 20, no. 16 (2010): R673—R675. http://dx.doi.org/10.1016/j.cub.2010.06.053.

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Khaleel, Nagarchi, Ravindranath Roopa, Jangama S. M. Smitha, and Chittaranjan Andrade. "Electroconvulsive Therapy Attenuates Dendritic Arborization in the Basolateral Amygdala." Journal of ECT 29, no. 3 (2013): 156–57. http://dx.doi.org/10.1097/yct.0b013e318282a6b1.

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Nanda, Sumit, Ravi Das, Shatabdi Bhattacharjee, Daniel N. Cox, and Giorgio A. Ascoli. "Morphological determinants of dendritic arborization neurons in Drosophila larva." Brain Structure and Function 223, no. 3 (2017): 1107–20. http://dx.doi.org/10.1007/s00429-017-1541-9.

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Machamer, James B., Brian M. Woolums, Gregory G. Fuller, and Thomas E. Lloyd. "FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons." Brain Research 1693 (August 2018): 55–66. http://dx.doi.org/10.1016/j.brainres.2018.03.037.

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Louis, Elan D., Michelle Lee, Rachel Babij, et al. "Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor." Brain 137, no. 12 (2014): 3142–48. http://dx.doi.org/10.1093/brain/awu314.

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Perng, Vivian, Chong Li, Shya Navazesh, et al. "Iron Deficiency and Iron Excess Alter Dendritic Architecture of Pyramidal Neurons in the Hippocampus of Neonatal Pigs." Current Developments in Nutrition 4, Supplement_2 (2020): 1232. http://dx.doi.org/10.1093/cdn/nzaa057_048.

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Abstract Objectives The study assessed effect of dietary iron on iron homeostasis and dendritic architecture of hippocampal neurons in young piglets. Methods On postnatal day (PD) 1, 30 piglets (15 male/female) were blocked by sex and randomized to treatments by receiving no (N), low (L) or high (H) dose of iron supplement during pre- (PD1–21) and post-weaning period (PD22–35). Pigs in N, L, and H group orally received 0, 1, and 30 mg iron/(kg BW· d) as ferrous sulfate solution pre-weaning and were fed a solid diet containing 30, 125, and 1000 mg iron/kg post-weaning, respectively. Blood sampl

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Yang, Wei-Kang, and Cheng-Ting Chien. "Beyond being innervated: the epidermis actively shapes sensory dendritic patterning." Open Biology 9, no. 3 (2019): 180257. http://dx.doi.org/10.1098/rsob.180257.

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Sensing environmental cues requires well-built neuronal circuits linked to the body surface. Sensory neurons generate dendrites to innervate surface epithelium, thereby making it the largest sensory organ in the body. Previous studies have illustrated that neuronal type, physiological function and branching patterns are determined by intrinsic factors. Perhaps for effective sensation or protection, sensory dendrites bind to or are surrounded by the substrate epidermis. Recent studies have shed light on the mechanisms by which dendrites interact with their substrates. These interactions suggest

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Urrego, Diana, Julieta Troncoso, and Alejandro Múnera. "Layer 5 Pyramidal Neurons’ Dendritic Remodeling and Increased Microglial Density in Primary Motor Cortex in a Murine Model of Facial Paralysis." BioMed Research International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/482023.

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This work was aimed at characterizing structural changes in primary motor cortex layer 5 pyramidal neurons and their relationship with microglial density induced by facial nerve lesion using a murine facial paralysis model. Adult transgenic mice, expressing green fluorescent protein in microglia and yellow fluorescent protein in projecting neurons, were submitted to either unilateral section of the facial nerve or sham surgery. Injured animals were sacrificed either 1 or 3weeks after surgery. Two-photon excitation microscopy was then used for evaluating both layer 5 pyramidal neurons and micro

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Bobo-Jiménez, Verónica, María Delgado-Esteban, Julie Angibaud, et al. "APC/CCdh1-Rock2 pathway controls dendritic integrity and memory." Proceedings of the National Academy of Sciences 114, no. 17 (2017): 4513–18. http://dx.doi.org/10.1073/pnas.1616024114.

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Disruption of neuronal morphology contributes to the pathology of neurodegenerative disorders such as Alzheimer’s disease (AD). However, the underlying molecular mechanisms are unknown. Here, we show that postnatal deletion of Cdh1, a cofactor of the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase in neurons [Cdh1 conditional knockout (cKO)], disrupts dendrite arborization and causes dendritic spine and synapse loss in the cortex and hippocampus, concomitant with memory impairment and neurodegeneration, in adult mice. We found that the dendrite destabilizer Rho protein kinase 2 (

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Baudouin, Stéphane J., Julie Angibaud, Gildas Loussouarn та ін. "The Signaling Adaptor Protein CD3ζ Is a Negative Regulator of Dendrite Development in Young Neurons". Molecular Biology of the Cell 19, № 6 (2008): 2444–56. http://dx.doi.org/10.1091/mbc.e07-09-0947.

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A novel idea is emergxsing that a large molecular repertoire is common to the nervous and immune systems, which might reflect the existence of novel neuronal functions for immune molecules in the brain. Here, we show that the transmembrane adaptor signaling protein CD3ζ, first described in the immune system, has a previously uncharacterized role in regulating neuronal development. Biochemical and immunohistochemical analyses of the rat brain and cultured neurons showed that CD3ζ is mainly expressed in neurons. Distribution of CD3ζ in developing cultured hippocampal neurons, as determined by im

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Germain, Francisco, Eduardo Fernandez, and Pedro de la Villa. "Morphometrical analysis of dendritic arborization in axotomized retinal ganglion cells." European Journal of Neuroscience 18, no. 5 (2003): 1103–9. http://dx.doi.org/10.1046/j.1460-9568.2003.02842.x.

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Zhang, Zaixiang, Diane M. Casey, Jean-Pierre Julien, and Zuoshang Xu. "Normal dendritic arborization in spinal motoneurons requires neurofilament subunit L." Journal of Comparative Neurology 450, no. 2 (2002): 144–52. http://dx.doi.org/10.1002/cne.10306.

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Liu, Yamei, Yunfei Tang, Jinyu Yan, Dongshu Du, Yang Yang, and Fuxue Chen. "Deletion of Kv10.2 Causes Abnormal Dendritic Arborization and Epilepsy Susceptibility." Neurochemical Research 45, no. 12 (2020): 2949–58. http://dx.doi.org/10.1007/s11064-020-03143-7.

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Richards, Laura A., and Christopher M. Schonhoff. "Nitric oxide and sex differences in dendritic branching and arborization." Journal of Neuroscience Research 99, no. 5 (2021): 1390–400. http://dx.doi.org/10.1002/jnr.24789.

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Paramo, Blanca, Sean Wyatt, and Alun M. Davies. "Neuregulin-4 Is Required for the Growth and Elaboration of Striatal Medium Spiny Neuron Dendrites." Journal of Neuropathology & Experimental Neurology 78, no. 8 (2019): 725–34. http://dx.doi.org/10.1093/jnen/nlz046.

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Abstract Medium spiny neurons (MSNs) comprise the vast majority of neurons in the striatum. Changes in the exuberant dendrites of these widely connected neurons are associated with a multitude of neurological conditions and are caused by a variety of recreational and medicinal drugs. However, we have a poor understanding of the physiological regulators of dendrite growth and elaboration of this clinically important population of neurons. Here, we show that MSN dendrites are markedly smaller and less branched in neonatal mice that possess a homozygous null mutation in the neuregulin-4 gene (Nrg

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Gogan, P., and S. Tyc-Dumont. "How Do Dendrites Process Neural Information?" Physiology 4, no. 4 (1989): 127–30. http://dx.doi.org/10.1152/physiologyonline.1989.4.4.127.

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The concept of neuronal computing has been evolving toward the idea that the three-dimensional form of dendritic arborization determines the computational abilities of the neuron. The architectural complexity of every single neuron in the brain is probably as important as connectivity for the performance of a neural network.

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Malis, Milos, Valentina Nikolic, Vuk Djulejic, Dejan Opric, Lukas Rasulic, and Laslo Puskas. "Morphometric characteristics of Neuropeptide Y immunoreactive neurons of human cortical amygdaloid nucleus." Medical review 61, no. 5-6 (2008): 235–41. http://dx.doi.org/10.2298/mpns0806235m.

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Introduction Cortical amygdaloid nucleus belongs to the corticomedial part of the amygdaloid complex. In this nucleus there are neurons that produce neuropetide Y. This peptide has important roles in sleeping, learning, memory, gastrointestinal regulation, anxiety, epilepsy, alcoholism and depression. Material and methods We investigated morphometric characteristics (numbers of primary dendrites, longer and shorter diameters of cell bodies and maximal radius of dendritic arborization) of NPY immunoreactive neurons of human cortical amygdaloid nucleus on 6 male adult human brains, aged 46 to 77

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Ichikawa, T. "MOTION-SENSITIVE CELLS: PUTATIVE LARVAL NEURONES INCORPORATED INTO THE OPTIC LOBE OF THE ADULT SWALLOWTAIL BUTTERFLY." Journal of Experimental Biology 195, no. 1 (1994): 361–80. http://dx.doi.org/10.1242/jeb.195.1.361.

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Intracellular recordings were made from neurones with large somata situated at the anteromedial edge of the medulla of the swallowtail butterfly Papilio xuthus; the neurones were then filled with Lucifer Yellow. These cells are putative larval visual interneurones incorporated into the adult optic lobe of the butterfly. There are four classes of motion-sensitive neurones. Two have a dendritic arborization in the dorsal half of the medulla and project an axon to the medial protocerebrum or the contralateral medulla. They respond to vertical downward motion with a strong burst of action potentia

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Aguirre-Chen, Cristina, Natalia Stec, Olivia Mendivil Ramos, et al. "A Caenorhabditis elegans Model for Integrating the Functions of Neuropsychiatric Risk Genes Identifies Components Required for Normal Dendritic Morphology." G3: Genes|Genomes|Genetics 10, no. 5 (2020): 1617–28. http://dx.doi.org/10.1534/g3.119.400925.

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Analysis of patient-derived DNA samples has identified hundreds of variants that are likely involved in neuropsychiatric diseases such as autism spectrum disorder (ASD) and schizophrenia (SCZ). While these studies couple behavioral phenotypes to individual genotypes, the number and diversity of candidate genes implicated in these disorders highlights the fact that the mechanistic underpinnings of these disorders are largely unknown. Here, we describe a RNAi-based screening platform that uses C. elegans to screen candidate neuropsychiatric risk genes (NRGs) for roles in controlling dendritic ar

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Blizinsky, Katherine D., Blanca Diaz-Castro, Marc P. Forrest, et al. "Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub." Proceedings of the National Academy of Sciences 113, no. 30 (2016): 8520–25. http://dx.doi.org/10.1073/pnas.1607014113.

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The architecture of dendritic arbors contributes to neuronal connectivity in the brain. Conversely, abnormalities in dendrites have been reported in multiple mental disorders and are thought to contribute to pathogenesis. Rare copy number variations (CNVs) are genetic alterations that are associated with a wide range of mental disorders and are highly penetrant. The 16p11.2 microduplication is one of the CNVs most strongly associated with schizophrenia and autism, spanning multiple genes possibly involved in synaptic neurotransmission. However, disease-relevant cellular phenotypes of 16p11.2 m

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