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Dissertations / Theses on the topic 'Dendritic cells Antigen presentation'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Chen, Liying. "Processing and presentation of exogenous antigen by dendritic cells /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-890-8/.

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2

Cebrián, José Ignacio. "Intracellular trafficking during antigen cross presentation in dendritic cells." Paris 5, 2011. http://www.theses.fr/2011PA05T045.

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Les cellules dendritiques (DCs) jouent un rôle essentiel dans l’initiation des réponses immunitaires adaptatives par les lymphocytes T. Ces cellules présentent des antigènes phagocytés sur les molécules de classe I et II du complexe majeur d’histocompatibilité (CMH) pour activer les lymphocytes T CD8+ et CD4+, respectivement. Contrairement à la présentation restreinte aux molécules de classe II du CMH, les voies intracellulaires impliquées dans la présentation des antigènes internalisés sur des molécules du CMH de classe I, un processus appelé présentation croisée, sont encore largement inconn

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3

Meltzer, Ulrike Anne. "Dendritic cell maturation and antigen presentation." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407647.

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4

Roberts, Mary Susan. "The effect of cyclosporine on antigen presentation by dendritic cells." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279000.

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5

Coughlan, Susan Nicola. "Antigen uptake and presentation by ovine afferent lymph dendritic cells." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/30970.

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Dendritic cells (DC) are accessory cells distributed throughout non-lymphoid and lymphoid tissues, and also found in the blood and afferent lymph. These cells represent 1-10% of the leucocytes in ovine afferent lymph, and can be purified using pseudoafferent cannulation techniques. DC are essential as accessory cells for the initiation of primary immune responses, and are also the most effective antigen presenting cells for activation of T cells in the secondary response. However, the mechanisms underlying the potent accessory capability of DC are currently poorly understood. The aims of this

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6

Pillay, Sirika. "Studies on cross presentation of antigen by human dendritic cells." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9562.

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It is widely acknowledged that an HIV-1 vaccine requires a robust CD8+ T-cell response to effectively combat HIV-1. However, past vaccine candidates have failed to stimulate adequate cellular responses in humans, highlighting the need to explore alternative ways to induce strong cellular immunity. Animal studies have shown that if exogenous antigen can be targeted to dendritic cells (DCs), strong CD8+ T-cell responses can be generated via the cross-presentation pathway. In this study we evaluated the ability of four DC surface receptors in two different human DC subsets (monocyte-derived DCs a

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7

Colledge, Lisa H. "Investigation of antigen presentation by murine bone marrow-derived dendritic cells." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312678.

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8

Gildea, Lucy Anne. "INTERACTIONS OF HISTOPLASMA CAPSULATUM YEASTS WITH HUMAN DENDRITIC CELLS." University of Cincinnati / OhioLINK, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=ucin976039664.

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9

Simmons, Daimon P. "Effects of Toll-Like Receptors and Type I Interferon on Dendritic Cell Maturation and Activation of T Cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1311278278.

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10

Patel, Rajen. "Dendritic Cells Mediate Protective Immunity Against Salmonella Typhimurium by Regulating Antigen Presentation, Inflammation and Cell Death." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34307.

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Salmonella enterica serovar Typhimurium (ST) is an intracellular bacterium that resides within the phagosome of infected cells. ST is the causative agent of gastroenteritis in humans and typhoid like disease in mice. ST infects epithelial cells and phagocytic cells such as dendritic cells (DCs), which are immune sentinels that have been regarded as the most critical antigen-presenting cell (APC). I evaluated the role of CD8α DCs, a subset of DCs capable of antigen presentation of phagosomal pathogens to activate CD8+ T cells. Furthermore, I assessed the role of key cytokines such as the group

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11

Johnson, Kenneth. "The Role of Gilt in the Cross Presentation of the Melanoma Antigen gp100." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623465.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>In this study we examine the utility of using CD8+ T cell hybridomas to measure the ability of bone marrow dendritic cells (BMDCs) to internalize cancer proteins and display them to cytotoxic T cells, a process termed cross‐presentation. We test the ability of a newly generated T cell hybridoma called BUSA14 to detect cross‐presentation of the melanoma antigen gp100. BUSA14 produces a dose‐dependent response to human and mouse gp100 p

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12

Rodríguez, Plata Mª Teresa. "Dendritic Cells and HIV-1: Molecular Mechanisms Involved in Viral Capture, Trans-infection and Antigen Presentation." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/120537.

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Les cèl·lules dendrítiques (CD) són les cèl·lules presentadores d’antigen més potents del sistema immuntari, enllaçant la immunitat innata i la immunitat adquirida. No obstant això, les CD poden contribuir a la disseminació del Virus de la Immuno-deficiència Humana tipus 1 (VIH-1) mentre intenten induir una resposta adaptativa contra la infecció viral. El paradigma immunològic clàssic sobre la funció de les CD indica que les CD immadures principalment capturen patògens, mentre que les CD madures indueixen una resposta adaptativa contra el patogen capturat. Però, la maduració de les CD amb lipo

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13

Divekar, Rohit Dilip Zaghouani Habib. "Two aspects of peripheral immune tolerance systemic and mucosal tolerance mechanisms /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6868.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on April 1, 2010). Vita. Thesis advisor: Habib Zaghouani. "May 2008" Includes bibliographical references.

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14

McDonnell, Alison. "The role of dendritic cells in the cross-presentation of tumour antigens." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0017.

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[Truncated abstract] A paradox exists in tumour immunology whereby progressive tumour growth exists in parallel with an anti-tumour T cell response. This defective T cell response is thought to result from the induction of T cell tolerance and/or tumour induced immunosuppression, which act to inhibit the activation, differentiation and function of tumour-specific CD8+ T cells. Dendritic cells (DCs) are professional antigen presenting cells (APCs) that are critical to the generation of effective CTL; however their function and phenotype is often defective or altered in tumour-bearing hosts, whi

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15

Rosenstock, Philip [Verfasser], and Stefan [Akademischer Betreuer] Dübel. "The influence of novel poxvirus-based HIV 1 vaccine candidates on antigen presentation by dendritic cells / Philip Rosenstock ; Betreuer: Stefan Dübel." Braunschweig : Technische Universität Braunschweig, 2012. http://d-nb.info/117582450X/34.

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16

Giusti, Pablo. "Characterization of antigen-presenting cell function in vitro and ex vivo." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-60433.

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Long-term protective immunity depends on proper initiation of professional antigen-presenting cells (APCs). Autoimmune disorders and certain infections can cause disease through modulation of APCs and thereby affecting the outcome of these diseases. This work aimed to investigate the behaviour of different APC subsets during conditions known to cause improper immune responses. In Paper I, the effects of an anti-inflammatory compound called Rabeximod, intended for treatment of rheumatoid arthritis were investigated on different subsets of APCs. The results showed that Rabeximod affected the dif

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17

Rad, A. "The differential influence of allogeneic tumour cell death via DNA damage on dendritic cell maturation and antigen presentation." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1381828/.

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Dendritic cells (DC) respond to danger signals from tissue injury by amplifying their immune-inducing capacity. In the cancer context, this may lead to in vivo anti-tumour synergism between DC and DNA-damaging chemotherapeutic agents. Neither the interaction between DC and dying tumour cells, nor whether different ways of inducing cell injury can deliver danger signals of different strength to DC, has been studied rigorously. Furthermore, the physical interactions of DC with injured tumour cell, and whether physical contact is required for sensing danger signals, have not been clearly defined.

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18

Fiff, Fabian. "Transfection of baboon dendritic cells with plasmid DNA containing HIV-1C genes : effect of transfection methods on antigen processing and presentation to T lymphocytes." Thesis, Link to the online version, 2005. http://hdl.handle.net/10019/1022.

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19

Solanes, Paola. "IP3 Receptor 3 controls migration persistency and environment patrolling by immature dendritic cells." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T020/document.

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Le succès de la réponse immunitaire repose en grande partie sur la capacité des leucocytes à se déplacer et à accomplir leur fonction au sein de structures anatomiques précises. Le fait qu’il puisse exister des mécanismes intrinsèques de coordination entre ces fonctions spécifiques et la migration de ces cellules n’a jamais été étudié auparavant. Nos travaux mettent en évidence, pour la première fois, l’existence d’un couplage entre la migration et la macropinocytose dans les cellules dendritiques qui explorent leur environnement en internalisant une grande quantité de matériel extra-cellulair

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20

Allen, Frederick Jr. "CCL3 Augments Antitumor Responses in CT26 by Enhancing Cellular Trafficking and Interferon-Gamma Expression." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1513124234665339.

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21

Garcia-Castillo, Maria Daniela. "Mechanisms of Endosomal Membrane Translocation Leading to Antigen Cross-presentation." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T075.

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Dans l'introduction, diverses voies de trafic intracellulaire et endocytose seront discutées. Je familiarise le lecteur avec des protéines inactivant les ribosomes, en mettant l'accent sur la structure, l'endocytose, et le trafic intracellulaire de la toxine bactérienne Shiga toxin (STX). STx et la ricine suivent la voie rétrograde pour exercer leur effet toxique sur les cellules. Ils sont respectivement, une menace maladie infectieuse pour la santé humaine et des outils potentiels pour le bioterrorisme pour lequel aucun antidote n’existe actuellement. D'un criblage à haut débit, Retro-1 et Re

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22

Bonmort, Mathieu. "Rôle des Interferon producing Killer Dendritic Cell (IKDC) dans l'immunité anti-tumorale inée et acquise." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T095.

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Nos travaux décrivent l’identification et la caractérisation d’une cellule immunitaire : l’IKDC pour Interferon Producing killer dendritic cell. Cette population cellulaire, découverte à la faveur de la combinaison Imatinib mesilate et Interleukine 2 dans le traitement des métastases pulmonaires de mélanome B16F10 chez la souris, combine des caractéristiques de cellule dendritique (présentation antigénique) et de cellule natural killer (lyse sans apprentissage). Le phénotype des IKDC est le suivant :CD3-, CD19-, CD11c+,B220+, NK1.1+. Nous avons établi une stratégie de culture des IKDC ex vivo

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23

Ramakrishna, Edukulla. "Strategies for improved cancer virotherapy in vivo migration and expansion of dendritic cells enhance cross-presentation of tumor antigens in virotherapy /." kostenfrei, 2008. http://d-nb.info/98826448X/34.

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24

Cruz, Freidrich M. "Identification and Characterization of Rab39a and Its Role in Crosspresentation." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/899.

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Crosspresentation allows antigen presenting cells to present peptides from exogenously derived antigens onto MHC Class I for presentation to CD8+ T cells. Though this pathway shares key players with the Classical Class I and Class II pathways, several questions remain. A genomewide siRNA screen was performed to look for genes that selectively affected the crosspresentation or the Class II pathways. Among the genes identified in the screen was the Rab GTPase Rab39a. Rab39a was required for efficient crosspresentation but was dispensable for the presentation of endogenously expressed antigen. Bo

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25

Evans, Heather M. "IMMUNE EVASION BY DIVISION OF LABOR: THE TROPHIC LIFE CYCLE STAGE OF PNEUMOCYSTIS MURINA SUPPRESSES INNATE IMMUNITY TO THIS OPPORTUNISTIC, FUNGAL PATHOGEN." UKnowledge, 2017. http://uknowledge.uky.edu/microbio_etds/15.

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Pneumocystis species are opportunistic fungal pathogens that cause severe pneumonia in immunocompromised hosts, including AIDS patients. Pneumocystis species have a biphasic life cycle consisting of single-nucleated trophic forms and ascus-like cysts. Both stages live within the host, and, thus, must contend with threats from the host immune system. The cyst cell wall β-glucans have been shown to stimulate immune responses in lung epithelial cells, dendritic cells and alveolar macrophages. Little is known about how the trophic life forms, which do not have a fungal cell wall, interact with imm

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26

Marguti, Ivo. "Efeito das células dendríticas na geração de células T CD4+CD25+Foxp3+." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-18102007-154828/.

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As células dendríticas (DCs) são as principais células apresentadoras de antígeno do sistema imune. No entanto, trabalhos têm demonstrado seu envolvimento na manutenção da tolerância imunológica. As células T CD4+CD25+Foxp3+ possuem a capacidade de suprimir respostas imunes. Neste estudo avaliamos as alterações ocorridas na população de células T CD4+CD25+Foxp3+ após co-cultura de células de linfonodo com DCs. Nossos resultados demonstram que após a co-cultura há um aumento da população de células CD4+CD25+Foxp3+ de maneira independente do estado de ativação das DCs ou da presença de antígenos

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27

Deauvieau, Florence. "Mise en évidence et caractérisation de la coopération entre les cellules NK et les cellules dendritiques humaines pour la présentation croisée d’antigènes." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10131.

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Les données de la littérature ont récemment souligné l’importance du dialogue réciproque qui s’instaure entre les cellules Natural Killer (NK) et les cellules dendritiques (DC) au cours des phases précoces de la réponse immune pour l’initiation des réponses T spécifiques. La présentation croisée d’antigènes (Ag), processus qui permet aux DC de présenter des Ag exprimés par d’autres cellules aux lymphocytes T CD8+, est requise pour le développement d’une immunité cellulaire spécifique dans la plupart des infections par des pathogènes intracellulaires et des tumeurs. L’étude des mécanismes physi

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28

Verfuerth, Stephanie. "In vitro expansion of donor-derived CMV-specific T lymphocytes for adoptive cellular therapy : optimisation of antigen presentation by dendritic cells, characterisation of the culture output, and adaptation of culture conditions to CMV-naiÌˆve donors". Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435182.

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Verfuerth, Stephanie. "In vitro expansion of donor-derived CMV-specific T lymphocytes for adoptive cellular therapy : optimisation of antigen presentation by dendritic cells, characterisation of the culture output, and adaptation of culture conditions to CMV-naïve donors." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445950/.

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Cytomegalovirus infection adversely affects the survival of haemopoietic stem cell transplant recipients, despite antiviral chemotherapy. As an alternative treatment, adoptive cellular therapy can transfer specific immunity from donor to recipient, avoiding drug side effects. A range of methods for the isolation and/or enrichment of CMV-specific donor- derived T cells have been explored. Our cell product comprises donor-derived CMV-specific T cells, enriched through co- culture with CMV antigen-presenting MoDC. These cells are currently assessed in two ongoing clinical studies. To further opti

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30

Babdor, Joël. "Biologie cellulaire des endosomes IRAP+ dans les cellules dendritiques." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T071.

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Par leur activité permanente à l’état basal et en situation infectieuse, les cellules dendritiques (DC) de l’organisme orchestrent la tolérance du soi et l’élimination du non-soi, en façonnant les réponses immunes. Ce rôle immunologique complexe des DC repose en grande partie sur des mécanismes de biologie cellulaire spécifiques, qui font l’objet d’un effort considérable de caractérisation. Le travail réalisé au cours de cette thèse met en lumière une sous-population endosomale jouant un rôle clé dans les processus cellulaires de modulation de l’immunité par les DC : les endosomes IRAP+ (insul

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31

Nyambura, Lydon Wainaina. "Impact of monocyte differentiation and intracellular infection on processing and presentation of autoantigen." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19154.

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Dendritische Zellen (DCs) und Makrophagen sind spezialisierte antigenpräsentierende Zellen, die eigene und fremde Antigene prozessieren und mittels Haupthistokompatibilitätsmoleküle, humane Leukozytenantige (HLA) im Menschen, T-Zellen präsentieren, um Toleranzen zu induzieren oder T-Zell-vermittelte Immunantworten zu initiieren. Abhängig von ihrer Differenzierung haben sie spezifische Phänotypen und Funktionen undunterschiedliche Interaktionen mit Pathogenen, in dieser Arbeit durch Leishmania donovani (LD) repräsentiert, welche in Phagolysosomen der Makrophagen propagieren. Der Einfluss der D

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32

Ollion, Vincent. "Caractérisation des cellules dendritiques humaines BDCA3high et de leur modulation par le microenvironnement tumoral." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10163/document.

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Les cellules dendritiques {DC) jouent un rôle majeur dans l'induction de l'immunité anti-tumorale spécifique de l'antigène {Ag). Récemment, les DC BDCA3high humaines sont apparues comme étant homologues aux DC CD8a+ connues pour activer très efficacement les lymphocytes T CD8 par présentation croisée d'Ag chez la souris. Par ailleurs, ces deux populations de DC sont les productrices principales d'interféron-λ{IFN-λ), une cytokine récemment découverte et possédant des propriétés antivirales, antiprolifératives et anti-tumorales. Mon travail de thèse a permis de mieux caractériser la présentatio

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33

Darmoise, Alexandre F. "Lysosomal alpha-galactosidase A controls the generation of self lipid antigens for NKT cells." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16292.

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CD1 Moleküle spielen eine wichtige Rolle in der Lipidpräsentation und T-Zell-Aktivierung. CD1d fungiert als Restriktionselement für NKT-Zellen, eine T-Zell-Untergruppe, die nach Erkennung von Glykosphingolipide (GSL), IFN-gamma und IL-4 produziert. NKT Zellen steuern folglich anschliessende Immunantworten. Den meisten infektiösen Mikroorganismen mangelt es jedoch an GSL-Antigenen zur Stimulation von NKT-Zellen. Der Wirtsorganismus hat daher einen Mechanismus entwickelt, der die Aktivierung der NKT-Zellen dennoch gewährleistet. NKT-Zellen erkennen auch endogene GSL, die in dendritischen Zellen

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34

Korneychuk, Natalia. "Analysis of the roles of Interleukin 15 and CD4+ T cells specific of a dietary antigen in a mouse model of celiac-like enteropathy." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T037/document.

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Dans les conditions physiologiques des robustes mécanismes immunologiques empêchent le développement des réponses exagérées aux antigènes alimentaires. En revanche, dans le cas de maladie céliaque, qui affecte environ 1% de la population occidentale, l’exposition au gluten alimentaire d’individus génétiquement prédisposés HLA-DQ2.5/DQ8 provoque l’entéropathie chronique de l’intestin grêle. Les études précédentes chez l’homme ont établi le rôle crucial de la réponse cellulaire T CD4+ restreinte par HLA-DQ2.5/DQ8 et spécifique du gluten. La réponse T CD4+ est nécessaire mais cependant insuffisan

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Silva, Laís Teodoro da. "Caracterização das células dendríticas utilizadas em um ensaio clínico de fase I/II de vacina terapêutica anti-HIV." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-19062017-103945/.

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INTRODUÇÃO: A imunoterapia baseada em células dendríticas derivadas de monócitos (MoDCs) constitui uma estratégia promissora para o tratamento de indivíduos infectados pelo HIV. Devido à sua notória plasticidade, populações heterogêneas de MoDCs podem ser obtidas in vitro, dependendo das condições da cultura. Consequentemente, a capacidade dessas células em secretar citocinas e expressar moléculas que participam do processo de apresentação antigênica (MHC, moléculas de adesão e coestimuladoras) é variável, podendo interferir no perfil e eficácia da resposta imune induzida pela terapia. Em noss

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Tang-Huau, Tsing-Lee. "Les cellules dendritiques inflammatoires humaines utilisent une voie non-cytosolique pour la présentation croisée Human naturally-occuring monocyte-derived dendritic cells cross-present antigens exclusively through a vacuolar pathway." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB001.

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La présentation d'antigènes exogènes sur les molécules du CMH de classe I, appelée cross- présentation, est essentielle pour l'induction des réponses T CD8 cytotoxiques. La manipulation de la cross-présentation est une stratégie thérapeutique attrayante, mais une meilleure compréhension des mécanismes impliqués est essentielle. Dans les cellules dendritiques (DC) de souris, la cross- présentation se fait par la voie «cytosolique» ou «vacuolaire», en fonction de la localisation intracellulaire de la dégradation de l'antigène. Nous avons déjà montré que la DC résidentes dans les organes lymphoïd

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De, Angelis Rigotti Francesca. "Rôle de l'ubiquitination dans le trafic cellulaire des molécules de présentation antigénique." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX22024.

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L’ubiquitinylation a été largement étudiée comme étant un mécanisme impliqué dans la régulation du trafic intracellulaire de nombreuses protéines membranaires. Mon travail a permis d’identifier MARCH-IX, une ubiquitine ligase exprimées dans les cellules de mammifères, comme un acteur important du trafic intracellulaire des molécules de présentation antigénique CD1a et CMH-I. En condition d'over-expression, MARCH-IX ubiquitinyle spécifiquement CD1a et CMH-I. Par ailleurs, en utilisant la technique d’ARN interférence, nous avons mis en évidence que l’ubiquitination des CMH I dépendante de MARCH

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Mebarek, Naila. "Optimisation d'un vecteur en immunothérapie avec les cellules dendritiques : micelles de copolymères à blocs double-hydrophiles." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON13526.

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L'objectif de cette thèse repose sur le développement de micelles de polymères polyioniques, vecteurs de molécules thérapeutiques en immunothérapie avec des cellules dendritiques (DCs). Elles sont préparées à partir d'un copolymère à blocs double-hydrophiles, l'acide polyméthacrylique-b-polyoxyde d'éthylène (PMAA-b-POE) et d'un contre ion de charge opposée. De taille nanométrique, elles sont capables d'encapsuler des molécules thérapeutiques selon une association tripartite originale et de se désassembler à pH acide pour permettre leur libération dans le milieu endosomal.Le premier axe de trav

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Baumgart, Daniel C. "Antigenpräsentation in der intestinalen Mukosa." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/13970.

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Die Ätiologie chronisch entzündlicher Darmerkrankungen ist bis heute ungeklärt. Sie beinhaltet eine unkontrollierte Aktivierung von immunologischen Effektorzellen durch antigenpräsentierende Zellen, wie zum Beispiel dendritische Zellen und intestinale Epithelzellen, die Antigene der luminalen Flora fehlerkennen und/oder falsch verarbeiten und den daraus resultierenden Gewebsschädigungsmechanismen. Am Interleukin-2 defizienten Mausmodell der Colitis ulcerosa konnten wir zeigen, daß T-Zellen eine zentrale Rolle beim mukosalen Entzündungsprozeß bei chronisch entzündlichen Darmerkrankungen und i

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Foster, Linda S. "Antigen presentation to cytotoxic T cells." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279882.

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Silvin, Aymeric. "Résistance sélective des sous-types de cellules dendritiques à l’infection par le VIH et le virus de la grippe." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB104/document.

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Les cellules dendritiques (DCs) détectent les particules virales et présentent les antigènes viraux afin d’organiser la réponse immunitaire. La réplication virale dans les DCs induit une réponse immune cytosolique. Comment les DCs tolèrent les virus afin de maintenir leur intégrité fonctionnelle est inconnu. Les DCs sont organisées en sous-populations distinctes d’un point de vue ontogénique. Nous avons observé que le virus du VIH et de la grippe infectaient préférentiellement les DCs CD1c+ par rapport au DCs CD141+ et aux pDCs. La réplication de ces virus au sein des DCs CD1c+ est essentielle

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Springer, Sebastian Hartmut. "The biochemistry of antigen presentation." Thesis, University of Oxford, 1996. http://ora.ox.ac.uk/objects/uuid:34d1afd2-fafc-4732-8e43-e00dcd8460d1.

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This thesis describes studies on the binding of peptides to the murine major histocompatibility complex (MHC) class I molecule H-2D<sup>b</sup> (D<sup>b</sup>). The expression of the recombinant soluble D<sup>b</sup> molecule in Chinese hamster ovary cells and its subsequent purification by nickel affinity chromatography, gel filtration, and preparative native isoelectric focusing are reported. The product is the correct molecule, homogeneous, a dimer of dimers, and free of endogenous peptide. A novel binding assay based on the enhancement of natural tryptophan fluorescence by the binding of p

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Brooks, Katharine E. "Uptake and presentation of antigen by B cells." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/438.

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B cells internalize antigen in a specific manner through the B cell receptor (BCR). The antigen is processed into peptides that are loaded on to MHC class II molecules and presented to CD4+ T cells. I have investigated factors that affect how the antigen is taken up, processed and presented. One way that B cells can obtain antigen is by extracting antigen that is tethered on cells in the form of immune complexes. Follicular dendritic cells (FDCs) are thought to be a type of cell that can provide antigen in this way. B cell acquisition of intact antigen from FDCs is thought to be important duri

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Mukwedeya, Daniel Tendayi. "Bovine B cells : heterogeneity, activation and targeted antigen presentation." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294747.

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Drakesmith, Alexander Hal. "Antigen processing and T cell priming by mouse dendritic cells." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300533.

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Singha, Sakon. "Antigen presentation in the small intestine of the pig." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269258.

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McDermott, Jacqueline Ruth. "The influence of dendritic cells on the differentiation of T helper cells." Thesis, University of Surrey, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326509.

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Drobbe, Lea [Verfasser]. "Inhibition of antigen presentation by primary antigen presenting cells through Helicobacter pylori / Lea Drobbe." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1202042465/34.

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Barroso, Herrera Osquel Miguel. "Manipulation of antigen-specific T cell responses by modified dendritic cells." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405941.

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Brammer, Clair Elizabeth. "The effects of inflammatory stimuli on antigen processing by dendritic cells." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394500.

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