Academic literature on the topic 'Dendritic cells ; Interleukin-4'

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Journal articles on the topic "Dendritic cells ; Interleukin-4"

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Maroof, Asher, Michelle Penny, Rosetta Kingston, et al. "Interleukin-4 can induce interleukin-4 production in dendritic cells." Immunology 117, no. 2 (2006): 271–79. http://dx.doi.org/10.1111/j.1365-2567.2005.02305.x.

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Szymczak, Wendy A., and George S. Deepe. "Antigen-Presenting Dendritic Cells Rescue CD4-Depleted CCR2−/− Mice from Lethal Histoplasma capsulatum Infection." Infection and Immunity 78, no. 5 (2010): 2125–37. http://dx.doi.org/10.1128/iai.00065-10.

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ABSTRACT Excessive production of interleukin-4 impairs clearance of the fungal pathogen Histoplasma capsulatum in mice lacking the chemokine receptor CCR2. An increase in the interleukin-4 level is associated with decreased recruitment of dendritic cells to lungs; therefore, we investigated the possibility that these cells influence interleukin-4 production. Adoptive transfer of wild-type or CCR2−/− bone marrow-derived dendritic cells loaded with heat-killed yeast cells to infected CCR2−/− mice suppressed interkeukin-4 transcription. Surprisingly, transfer of cells did not reduce the fungal bu
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Sauma, D., P. Michea, A. M. Lennon-Dumenil, et al. "Interleukin-4 Selectively Inhibits Interleukin-2 Secretion by Lipopolysaccharide-Activated Dendritic Cells." Scandinavian Journal of Immunology 59, no. 2 (2004): 183–89. http://dx.doi.org/10.1111/j.0300-9475.2004.01380.x.

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Gu, Wenyi, Jiezhong Chen, Lei Yang та Kong-Nan Zhao. "TNF-αPromotes IFN-γ-Induced CD40 Expression and Antigen Process in Myb-Transformed Hematological Cells". Scientific World Journal 2012 (2012): 1–11. http://dx.doi.org/10.1100/2012/621969.

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Tumour necrosis factor-α, interferon-γand interleukin-4 are critical cytokines in regulating the immune responses against infections and tumours. In this study, we investigated the effects of three cytokines on CD40 expression in Myb-transformed hematological cells and their regulatory roles in promoting these cells into dendritic cells. We observed that both interleukin-4 and interferon-γincreased CD40 expression in these hematological cells in a dose-dependent manner, although the concentration required for interleukin-4 was significantly higher than that for interferon-γ. We found that tumo
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Yamada, Nobuo, and Stephen Katz. "Induction of mature dendritic cells from a murine epidermal dendritic cell line (XS52) using interleukin-4." Journal of Dermatological Science 16 (March 1998): S16. http://dx.doi.org/10.1016/s0923-1811(98)83093-4.

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Cortés-Selva, Diana, Lisa Gibbs, Andrew Ready, et al. "Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion." PLOS Pathogens 17, no. 2 (2021): e1009260. http://dx.doi.org/10.1371/journal.ppat.1009260.

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Epidemiological studies have identified a correlation between maternal helminth infections and reduced immunity to some early childhood vaccinations, but the cellular basis for this is poorly understood. Here, we investigated the effects of maternal Schistosoma mansoni infection on steady-state offspring immunity, as well as immunity induced by a commercial tetanus/diphtheria vaccine using a dual IL-4 reporter mouse model of maternal schistosomiasis. We demonstrate that offspring born to S. mansoni infected mothers have reduced circulating plasma cells and peripheral lymph node follicular dend
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Li, Junzhao, Yonghai Zhang, Hongmei Qiao, Yingji Jin, Jianmin Wang та Binghua Yao. "Chlorobenzoxime inhibits respiratory syncytial virus infection in neonatal rats via up-regulation of IFN-γ in dendritic cells". Tropical Journal of Pharmaceutical Research 19, № 2 (2020): 239–46. http://dx.doi.org/10.4314/tjpr.v19i2.4.

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Purpose: To investigate the effect of chlorobenzoxime on respiratory syncytial virus (RSV) infection in vitro in lung alveolar cells and in vivo in neonatal rats, as well as the mechanism of action involved.
 Methods: RSV infection in neonatal rats was induced via intranasal administration of 2 x 106PFU viral particles. Reverse transcriptase-polymerase chain reaction (RT-PCR) and western blotting were used for determination of changes in interleukin expression.
 Results: RSV infection in BEAS-2B cells caused significant reduction in viability and marked alteration in morphological ap
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Chen, Fangxue, Meng Hou, Feng Ye, Weiguo Lv, and Xing Xie. "Ovarian Cancer Cells Induce Peripheral Mature Dendritic Cells to Differentiate Into Macrophagelike Cells In Vitro." International Journal of Gynecologic Cancer 19, no. 9 (2009): 1487–93. http://dx.doi.org/10.1111/igc.0b013e3181bb70c6.

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Aims:Precursors of dendritic cells (DCs) are able to differentiate into macrophages induced by some tumor-associated molecules; however, whether peripheral mature DCs could differentiate into macrophages remains unknown. This study was designed to find out whether ovarian cancer cells could induce peripheral mature DCs to differentiate into macrophages.Main Methods:Mature DCs were cultured from monocytes with granulocyte-macrophage colony-stimulating factor and interleukin 4 (IL-4) for 6 days and lipopolysaccharide for another 24 hours and then were cocultured for 48 hours with ovarian cancer
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Dietz, Allan B., and Stanimir Vuk-Pavlovic. "High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells." Blood 91, no. 2 (1998): 392–98. http://dx.doi.org/10.1182/blood.v91.2.392.

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Abstract The interest in the use of human dendritic cells in cancer immunotherapy calls for efficient ex vivo methods of dendritic cell education. To extend the range of methods available, we generated phenotypically characteristic dendritic cells from peripheral blood monocytes incubated with granulocyte-macrophage colony-stimulating factor and interleukin-4 and infected them with an adenovirus containing a humanized version of green fluorescent protein as a marker of gene expression. The levels of expressed protein were high, but they were further increased in combination with cationic lipos
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Dietz, Allan B., and Stanimir Vuk-Pavlovic. "High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells." Blood 91, no. 2 (1998): 392–98. http://dx.doi.org/10.1182/blood.v91.2.392.392_392_398.

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The interest in the use of human dendritic cells in cancer immunotherapy calls for efficient ex vivo methods of dendritic cell education. To extend the range of methods available, we generated phenotypically characteristic dendritic cells from peripheral blood monocytes incubated with granulocyte-macrophage colony-stimulating factor and interleukin-4 and infected them with an adenovirus containing a humanized version of green fluorescent protein as a marker of gene expression. The levels of expressed protein were high, but they were further increased in combination with cationic liposomes. In
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Dissertations / Theses on the topic "Dendritic cells ; Interleukin-4"

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Jones, Lucy Helen. "Alternative activation of dendritic cells." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8284.

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The alternative activation of macrophage populations by Interleukin-4 (IL-4) is well characterised. Alternatively activated macrophages (AAM) express high levels of the arginine converting enzyme arginase-1, and express a plethora of IL-4 driven molecules including the resistin like molecule alpha (RELMα) and the chitinase like molecule Ym1/2. Dendritic cells (DCs) are the professional antigen presenting cells (APC) of the immune system, responsible for the detection of invading pathogens, secretion of cytokines and the subsequent activation of T-cells. This thesis addresses whether IL-4 is ab
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Johansson, Petronella. "Characterisation of putative dendritic cell markers in salmonids and modulation of gene expression following stimulation with interleukin-4/13." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=216323.

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Dendritic cells (DCs) are leukocytes specialized in antigen presentation. As competent stimulators of naive T lymphocytes, they link the innate and adaptive immune responses of vertebrates. The RAG-mediated adaptive immune system appeared approximately 500 million years ago in jawed fish and a number of studies suggest that DCs exist in bony and cartilaginous fish. However, the exact role of DCs in the fish immune system is not determined and questions remain as to whether a cell type truly homologous to DCs in homeotherms does exist. My project aimed to identify potential DCs surface markers
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Anthony, Robert McCullough. "Characterization and function of the inflammatory response to infection by a gastrointestinal nematode parasite : new insights into protective Th2 responses /." Download the dissertation in PDF, 2006. http://www.lrc.usuhs.mil/dissertations/pdf/Anthony2006.pdf.

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Goff, Randal Donald. "Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells." BYU ScholarsArchive, 2006. https://scholarsarchive.byu.edu/etd/942.

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Glycosphingolipids (GSLs), composed of a polar saccharide head and a lipophilic ceramide tail, are ubiquitous components of the plasma membrane of eukaryotic cells. They serve in many regulatory capacities and have antigenic properties towards natural killer T (NKT) cells of the innate immune system. Critical to the recognition of glycosylceramides by NKT cells are antigen presenting cells (APC), such as dendritic cells, which are responsible for binding, processing, and delivery of ligands to these lymphocytes. This event is mediated by CD1d, a major histocompatibility complex-like protein ex
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Masic, Anita [Verfasser], and Heidrun [Akademischer Betreuer] Moll. "Signaling via Interleukin-4 Receptor alpha chain during dendritic cell–mediated vaccination is required to induce protective immunity against Leishmania major in susceptible BALB/c mice / Anita Masic. Betreuer: Heidrun Moll." Würzburg : Universitätsbibliothek der Universität Würzburg, 2013. http://d-nb.info/1031379762/34.

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Redondo, Ana Carolina Costa. "Avaliação da resposta inflamatória e da resposta imune inata na célula apresentadora de antígeno em recém-nascidos de termo sepse tardia." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-04022014-154223/.

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INTRODUÇÃO: Apesar do contínuo progresso no tratamento e suporte clínico a sepse continua sendo uma das principais causas de morbidade e mortalidade nas unidades de terapia intensiva, com desfechos semelhantes ao longo dos últimos 50 anos. A suscetibilidade à infecção grave no recém-nascido é parcialmente devida à imaturidade do sistema imune inato associado à mínima em exposição antigênica in utero e à ação ineficaz das células T efetoras e das célula B. Embora a ativação do sistema imune inato por padrões de reconhecimento (PRR) como os dos receptores Toll-like (TLR) tenham sua importância a
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You, Yi-Te, and 尤儀德. "Generation of Mature Dendritic Cells from Murine Splenocytes Cultured with Tumor Cells Transduced with GM-CSF and Interleukin-4 Genes: Implications for tumor Immunotherapy." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/64465342271662030870.

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碩士<br>國立成功大學<br>微生物暨免疫學研究所<br>88<br>Tumor vaccines derived from genetically modified tumor cells or from tumor antigen-pulsed dendritic cells (DCs) show promise in cancer immunotherapy. DCs can be generated from bone marrow-derived cells and splenocytes in the presence of GM-CSF and IL-4. DCs would mature into functional tumor antigen-presenting cells under the exposure to tumor cells or tumor extracts. In this study, the strategies based on DCs combined with genetically engineered tumor cells expressing GM-CSF and IL-4 were exploited to test the feasibility of generation of mature DCs in vitr
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Masic, Anita. "Signaling via Interleukin-4 Receptor alpha chain during dendritic cell–mediated vaccination is required to induce protective immunity against Leishmania major in susceptible BALB/c mice." Doctoral thesis, 2012. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-75508.

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Cutaneous leishmaniasis is endemic in tropical and subtropical regions of the world. Effective vaccination strategies are urgently needed because of the emergence of drug-resistant parasites and severe side effects of chemotherapy. The research group of Heidrun Moll previously established a DC-based vaccination strategy to induce complete and long-lasting immunity to experimental leishmaniasis using LmAg-loaded and CpG ODN-activated DC as a vaccine carrier. Prevention of tissue damages at the site of L. major inoculation can be achieved if the BALB/c mice were systemically given LmAg-loaded BM
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Book chapters on the topic "Dendritic cells ; Interleukin-4"

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Magerstaedt, Roland, Stefan Kraft, Isolde Strobel, et al. "Induction of FcεRIα mRNA and Protein Synthesis by Interleukin 4 in CD34+ Cells-Derived Cd1a+ Dendritic Cells." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4757-9966-8_57.

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Krauss, Susanne, Elfriede Mayer, Gerti Rank, and E. Peter Rieber. "Induction of the Low Affinity Receptor for IgE (FcεRII/CD23) on Human Blood Dendritic Cells by Interleukin-4." In Advances in Experimental Medicine and Biology. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2930-9_39.

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