Relevant bibliographies by topics / Dendritic cells ; Interleukin-4 / Journal articles
To see the other types of publications on this topic, follow the link: Dendritic cells ; Interleukin-4.

Journal articles on the topic 'Dendritic cells ; Interleukin-4'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Dendritic cells ; Interleukin-4.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Maroof, Asher, Michelle Penny, Rosetta Kingston, et al. "Interleukin-4 can induce interleukin-4 production in dendritic cells." Immunology 117, no. 2 (2006): 271–79. http://dx.doi.org/10.1111/j.1365-2567.2005.02305.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Szymczak, Wendy A., and George S. Deepe. "Antigen-Presenting Dendritic Cells Rescue CD4-Depleted CCR2−/− Mice from Lethal Histoplasma capsulatum Infection." Infection and Immunity 78, no. 5 (2010): 2125–37. http://dx.doi.org/10.1128/iai.00065-10.

Full text
Abstract:
ABSTRACT Excessive production of interleukin-4 impairs clearance of the fungal pathogen Histoplasma capsulatum in mice lacking the chemokine receptor CCR2. An increase in the interleukin-4 level is associated with decreased recruitment of dendritic cells to lungs; therefore, we investigated the possibility that these cells influence interleukin-4 production. Adoptive transfer of wild-type or CCR2−/− bone marrow-derived dendritic cells loaded with heat-killed yeast cells to infected CCR2−/− mice suppressed interkeukin-4 transcription. Surprisingly, transfer of cells did not reduce the fungal bu
APA, Harvard, Vancouver, ISO, and other styles
3

Sauma, D., P. Michea, A. M. Lennon-Dumenil, et al. "Interleukin-4 Selectively Inhibits Interleukin-2 Secretion by Lipopolysaccharide-Activated Dendritic Cells." Scandinavian Journal of Immunology 59, no. 2 (2004): 183–89. http://dx.doi.org/10.1111/j.0300-9475.2004.01380.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Gu, Wenyi, Jiezhong Chen, Lei Yang та Kong-Nan Zhao. "TNF-αPromotes IFN-γ-Induced CD40 Expression and Antigen Process in Myb-Transformed Hematological Cells". Scientific World Journal 2012 (2012): 1–11. http://dx.doi.org/10.1100/2012/621969.

Full text
Abstract:
Tumour necrosis factor-α, interferon-γand interleukin-4 are critical cytokines in regulating the immune responses against infections and tumours. In this study, we investigated the effects of three cytokines on CD40 expression in Myb-transformed hematological cells and their regulatory roles in promoting these cells into dendritic cells. We observed that both interleukin-4 and interferon-γincreased CD40 expression in these hematological cells in a dose-dependent manner, although the concentration required for interleukin-4 was significantly higher than that for interferon-γ. We found that tumo
APA, Harvard, Vancouver, ISO, and other styles
5

Yamada, Nobuo, and Stephen Katz. "Induction of mature dendritic cells from a murine epidermal dendritic cell line (XS52) using interleukin-4." Journal of Dermatological Science 16 (March 1998): S16. http://dx.doi.org/10.1016/s0923-1811(98)83093-4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Cortés-Selva, Diana, Lisa Gibbs, Andrew Ready, et al. "Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion." PLOS Pathogens 17, no. 2 (2021): e1009260. http://dx.doi.org/10.1371/journal.ppat.1009260.

Full text
Abstract:
Epidemiological studies have identified a correlation between maternal helminth infections and reduced immunity to some early childhood vaccinations, but the cellular basis for this is poorly understood. Here, we investigated the effects of maternal Schistosoma mansoni infection on steady-state offspring immunity, as well as immunity induced by a commercial tetanus/diphtheria vaccine using a dual IL-4 reporter mouse model of maternal schistosomiasis. We demonstrate that offspring born to S. mansoni infected mothers have reduced circulating plasma cells and peripheral lymph node follicular dend
APA, Harvard, Vancouver, ISO, and other styles
7

Li, Junzhao, Yonghai Zhang, Hongmei Qiao, Yingji Jin, Jianmin Wang та Binghua Yao. "Chlorobenzoxime inhibits respiratory syncytial virus infection in neonatal rats via up-regulation of IFN-γ in dendritic cells". Tropical Journal of Pharmaceutical Research 19, № 2 (2020): 239–46. http://dx.doi.org/10.4314/tjpr.v19i2.4.

Full text
Abstract:
Purpose: To investigate the effect of chlorobenzoxime on respiratory syncytial virus (RSV) infection in vitro in lung alveolar cells and in vivo in neonatal rats, as well as the mechanism of action involved.
 Methods: RSV infection in neonatal rats was induced via intranasal administration of 2 x 106PFU viral particles. Reverse transcriptase-polymerase chain reaction (RT-PCR) and western blotting were used for determination of changes in interleukin expression.
 Results: RSV infection in BEAS-2B cells caused significant reduction in viability and marked alteration in morphological ap
APA, Harvard, Vancouver, ISO, and other styles
8

Chen, Fangxue, Meng Hou, Feng Ye, Weiguo Lv, and Xing Xie. "Ovarian Cancer Cells Induce Peripheral Mature Dendritic Cells to Differentiate Into Macrophagelike Cells In Vitro." International Journal of Gynecologic Cancer 19, no. 9 (2009): 1487–93. http://dx.doi.org/10.1111/igc.0b013e3181bb70c6.

Full text
Abstract:
Aims:Precursors of dendritic cells (DCs) are able to differentiate into macrophages induced by some tumor-associated molecules; however, whether peripheral mature DCs could differentiate into macrophages remains unknown. This study was designed to find out whether ovarian cancer cells could induce peripheral mature DCs to differentiate into macrophages.Main Methods:Mature DCs were cultured from monocytes with granulocyte-macrophage colony-stimulating factor and interleukin 4 (IL-4) for 6 days and lipopolysaccharide for another 24 hours and then were cocultured for 48 hours with ovarian cancer
APA, Harvard, Vancouver, ISO, and other styles
9

Dietz, Allan B., and Stanimir Vuk-Pavlovic. "High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells." Blood 91, no. 2 (1998): 392–98. http://dx.doi.org/10.1182/blood.v91.2.392.

Full text
Abstract:
Abstract The interest in the use of human dendritic cells in cancer immunotherapy calls for efficient ex vivo methods of dendritic cell education. To extend the range of methods available, we generated phenotypically characteristic dendritic cells from peripheral blood monocytes incubated with granulocyte-macrophage colony-stimulating factor and interleukin-4 and infected them with an adenovirus containing a humanized version of green fluorescent protein as a marker of gene expression. The levels of expressed protein were high, but they were further increased in combination with cationic lipos
APA, Harvard, Vancouver, ISO, and other styles
10

Dietz, Allan B., and Stanimir Vuk-Pavlovic. "High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells." Blood 91, no. 2 (1998): 392–98. http://dx.doi.org/10.1182/blood.v91.2.392.392_392_398.

Full text
Abstract:
The interest in the use of human dendritic cells in cancer immunotherapy calls for efficient ex vivo methods of dendritic cell education. To extend the range of methods available, we generated phenotypically characteristic dendritic cells from peripheral blood monocytes incubated with granulocyte-macrophage colony-stimulating factor and interleukin-4 and infected them with an adenovirus containing a humanized version of green fluorescent protein as a marker of gene expression. The levels of expressed protein were high, but they were further increased in combination with cationic liposomes. In
APA, Harvard, Vancouver, ISO, and other styles
11

Yao, Yongxue, Wei Li, Mark H. Kaplan, and Cheong-Hee Chang. "Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells." Journal of Experimental Medicine 201, no. 12 (2005): 1899–903. http://dx.doi.org/10.1084/jem.20050324.

Full text
Abstract:
Interleukin (IL)-4 is known to be the most potent cytokine that can initiate Th2 cell differentiation. Paradoxically, IL-4 instructs dendritic cells (DCs) to promote Th1 cell differentiation. We investigated the mechanisms by which IL-4 directs CD4 T cells toward the Th1 cell lineage. Our study demonstrates that the IL-4–mediated induction of Th1 cell differentiation requires IL-10 production by DCs. IL-4 treatment of DCs in the presence of lipopolysaccharide or CpG resulted in decreased production of IL-10, which was accompanied by enhanced IL-12 production. In IL-10–deficient DCs, the level
APA, Harvard, Vancouver, ISO, and other styles
12

Garrigan, K., P. Moroni-Rawson, C. McMurray, et al. "Functional comparison of spleen dendritic cells and dendritic cells cultured in vitro from bone marrow precursors." Blood 88, no. 9 (1996): 3508–12. http://dx.doi.org/10.1182/blood.v88.9.3508.bloodjournal8893508.

Full text
Abstract:
We have compared dendritic cells (DC) isolated from mouse spleen, or generated in vitro from bone marrow (BM) precursors cultured in granulocyte macrophage-colony stimulating factor (GM-CSF) and interleukin-4 (IL-4), for the ability to process and present soluble antigen and stimulate major histocompatibility complex (MHC) Class II-restricted T cells. DC from spleen or BM cultures were equally able to stimulate the in vitro proliferation of allogeneic T cells or of antigen-specific T-cell receptor (TCR)-transgenic T cells. Both DC populations also induced comparable levels of IL-2 secretion by
APA, Harvard, Vancouver, ISO, and other styles
13

BROEN, JASPER C. A., PHILLIPE DIEUDE, MADELON C. VONK, et al. "Polymorphisms in the Interleukin 4, Interleukin 13, and Corresponding Receptor Genes Are Not Associated with Systemic Sclerosis and Do Not Influence Gene Expression." Journal of Rheumatology 39, no. 1 (2011): 112–18. http://dx.doi.org/10.3899/jrheum.110235.

Full text
Abstract:
Objective.Polymorphisms in the genes encoding interleukin 4 (IL4), interleukin 13 (IL13), and their corresponding receptors have been associated with multiple immune-mediated diseases. Our aim was to validate these previous observations in patients with systemic sclerosis (SSc) and scrutinize the effect of the polymorphisms on gene expression in various populations of peripheral blood leukocytes.Methods.We genotyped a cohort of 2488 patients with SSc and 2246 healthy controls from The Netherlands, Spain, United Kingdom, Italy, Germany, and France. Taqman assays were used to genotype single-nuc
APA, Harvard, Vancouver, ISO, and other styles
14

Xu, Xiongfei, Zhenhong Guo, Xueyu Jiang, et al. "Regulatory dendritic cells program generation of interleukin-4–producing alternative memory CD4 T cells with suppressive activity." Blood 117, no. 4 (2011): 1218–27. http://dx.doi.org/10.1182/blood-2010-05-285494.

Full text
Abstract:
Abstract The heterogeneity and mechanisms for the generation of CD4 memory T (CD4 Tm) cells remain elusive. Distinct subsets of dendritic cells (DCs) have been found to regulate a distinct T-helper (Th)–cell subset differentiation by influencing cytokine cues around CD4 T cells; however, whether and how the regulatory DC subset can regulate Tm-cell differentiation remains unknown. Further, there is no ideal in vitro experimental system with which to mimic the 3 phases of the CD4 T-cell immune response (expansion, contraction, memory generation) and/or to culture CD4 Tm cells for more than a mo
APA, Harvard, Vancouver, ISO, and other styles
15

Reddy, Anita, Mark Sapp, Mary Feldman, Marion Subklewe, and Nina Bhardwaj. "A Monocyte Conditioned Medium Is More Effective Than Defined Cytokines in Mediating the Terminal Maturation of Human Dendritic Cells." Blood 90, no. 9 (1997): 3640–46. http://dx.doi.org/10.1182/blood.v90.9.3640.

Full text
Abstract:
Abstract Mature human dendritic cells can be generated in substantial numbers from nonproliferating progenitors in human blood using a two-step protocol. T cell–depleted mononuclear cells are first cultured with granulocyte-macrophage colony-stimulating factor and interleukin-4 (IL-4) and then exposed to monocyte conditioned medium (MCM). The dendritic cells generated using this approach are rendered terminally mature and are the most potent antigen presenting cells identified to date in humans. We sought to characterize factors in MCM that induce the terminal differentiation of dendritic cell
APA, Harvard, Vancouver, ISO, and other styles
16

Zhang, Angela L., Paula Colmenero, Ulrich Purath, et al. "Natural killer cells trigger differentiation of monocytes into dendritic cells." Blood 110, no. 7 (2007): 2484–93. http://dx.doi.org/10.1182/blood-2007-02-076364.

Full text
Abstract:
Circulating monocytes can differentiate into dendritic cells (moDCs), which are potent inducers of adaptive immune responses. Previous reports show that granulocyte macrophage–colony-stimulating factor (GM-CSF) and interleukin-4 induce monocyte differentiation into moDCs in vitro, but little is known about the physiological requirements that initiate moDC differentiation in vivo. Here we show that a unique natural killer (NK) cell subset (CD3−CD56bright) that accumulates in lymph nodes and chronically inflamed tissues triggers CD14+ monocytes to differentiate into potent T-helper-1 (TH1) promo
APA, Harvard, Vancouver, ISO, and other styles
17

d'Ostiani, Cristiana Fè, Giuseppe Del Sero, Angela Bacci, et al. "Dendritic Cells Discriminate between Yeasts and Hyphae of the Fungus Candida albicans." Journal of Experimental Medicine 191, no. 10 (2000): 1661–74. http://dx.doi.org/10.1084/jem.191.10.1661.

Full text
Abstract:
The fungus Candida albicans behaves as a commensal as well as a true pathogen of areas highly enriched in dendritic cells, such as skin and mucosal surfaces. The ability of the fungus to reversibly switch between unicellular yeast to filamentous forms is thought to be important for virulence. However, whether it is the yeast or the hyphal form that is responsible for pathogenicity is still a matter of debate. Here we show the interaction, and consequences, of different forms of C. albicans with dendritic cells. Immature myeloid dendritic cells rapidly and efficiently phagocytosed both yeasts a
APA, Harvard, Vancouver, ISO, and other styles
18

WANG, SHIZHONG, XIAO SUN, HAIJUN ZHOU, ZHICHAO ZHU, WENJIE ZHAO, and CHUNFU ZHU. "Interleukin-4 affects the mature phenotype and function of rat bone marrow-derived dendritic cells." Molecular Medicine Reports 12, no. 1 (2012): 233–37. http://dx.doi.org/10.3892/mmr.2015.3349.

Full text
APA, Harvard, Vancouver, ISO, and other styles
19

Jose, Purnima, Margarita G. Avdiushko, Shizuo Akira, Alan M. Kaplan, and Donald A. Cohen. "INHIBITION OF INTERLEUKIN-10 SIGNALING IN LUNG DENDRITIC CELLS BY TOLL-LIKE RECEPTOR 4 LIGANDS." Experimental Lung Research 35, no. 1 (2009): 1–28. http://dx.doi.org/10.1080/01902140802389727.

Full text
APA, Harvard, Vancouver, ISO, and other styles
20

Mohamadzadeh, Mansour, Frederic Berard, Gregory Essert, et al. "Interleukin 15 Skews Monocyte Differentiation into Dendritic Cells with Features of Langerhans Cells." Journal of Experimental Medicine 194, no. 7 (2001): 1013–20. http://dx.doi.org/10.1084/jem.194.7.1013.

Full text
Abstract:
Langerhans cells (LCs) represent a subset of immature dendritic cells (DCs) specifically localized in the epidermis and other mucosal epithelia. As surrounding keratinocytes can produce interleukin (IL)-15, a cytokine that utilizes IL-2Rγ chain, we analyzed whether IL-15 could skew monocyte differentiation into LCs. Monocytes cultured for 6 d with granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-15 differentiate into CD1a+HLA-DR+CD14−DCs (IL15-DCs). Agents such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)α, and CD40L induce maturation of IL15-DCs to CD83+, DC-LAMP+
APA, Harvard, Vancouver, ISO, and other styles
21

Terawaki, Seigo, Voahirana Camosseto, Francesca Prete, et al. "RUN and FYVE domain–containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4." Journal of Cell Biology 210, no. 7 (2015): 1133–52. http://dx.doi.org/10.1083/jcb.201501059.

Full text
Abstract:
Autophagy is a key degradative pathway coordinated by external cues, including starvation, oxidative stress, or pathogen detection. Rare are the molecules known to contribute mechanistically to the regulation of autophagy and expressed specifically in particular environmental contexts or in distinct cell types. Here, we unravel the role of RUN and FYVE domain–containing protein 4 (RUFY4) as a positive molecular regulator of macroautophagy in primary dendritic cells (DCs). We show that exposure to interleukin-4 (IL-4) during DC differentiation enhances autophagy flux through mTORC1 regulation a
APA, Harvard, Vancouver, ISO, and other styles
22

Brandt, Katja, Silvia Bulfone-Paus, Donald C. Foster, and René Rückert. "Interleukin-21 inhibits dendritic cell activation and maturation." Blood 102, no. 12 (2003): 4090–98. http://dx.doi.org/10.1182/blood-2003-03-0669.

Full text
Abstract:
Abstract Interleukin 21 (IL-21) is a newly described cytokine with homology to IL-4 and IL-15. They belong to a cytokine family that uses the common γ chain for signaling but also have their private high-affinity receptors. Since it is well known that IL-4 modulates differentiation and activation of dendritic cells (DCs), we analyzed effects of IL-21 compared with IL-15 on DC differentiation, maturation, and function. Here we show that DCs generated with granulocyte-macrophage colony-stimulating factor (GMCSF) in the presence of IL-21 (IL-21DCs) differentiated into phenotypically and functiona
APA, Harvard, Vancouver, ISO, and other styles
23

Ohishi, Kohshi, Barbara Varnum-Finney, Rita E. Serda, Claudio Anasetti, and Irwin D. Bernstein. "The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells." Blood 98, no. 5 (2001): 1402–7. http://dx.doi.org/10.1182/blood.v98.5.1402.

Full text
Abstract:
Notch-mediated cellular interactions are known to regulate cell fate decisions in various developmental systems. A previous report indicated that monocytes express relatively high amounts of Notch-1 and Notch-2 and that the immobilized extracellular domain of the Notch ligand, Delta-1 (Deltaext-myc), induces apoptosis in peripheral blood monocytes cultured with macrophage colony-stimulating factor (M-CSF), but not granulocyte-macrophage CSF (GM-CSF). The present study determined the effect of Notch signaling on monocyte differentiation into macrophages and dendritic cells. Results showed that
APA, Harvard, Vancouver, ISO, and other styles
24

Kadowaki, Norimitsu, Svetlana Antonenko, Stephen Ho, et al. "Distinct Cytokine Profiles of Neonatal Natural Killer T Cells after Expansion with Subsets of Dendritic Cells." Journal of Experimental Medicine 193, no. 10 (2001): 1221–26. http://dx.doi.org/10.1084/jem.193.10.1221.

Full text
Abstract:
Natural killer T (NKT) cells are a highly conserved subset of T cells that have been shown to play a critical role in suppressing T helper cell type 1–mediated autoimmune diseases and graft versus host disease in an interleukin (IL)-4–dependent manner. Thus, it is important to understand how the development of IL-4– versus interferon (IFN)-γ–producing NKT cells is regulated. Here, we show that NKT cells from adult blood and those from cord blood undergo massive expansion in cell numbers (500–70,000-fold) during a 4-wk culture with IL-2, IL-7, phytohemagglutinin, anti-CD3, and anti-CD28 mAbs. U
APA, Harvard, Vancouver, ISO, and other styles
25

Schüler, Thomas, Thomas Kammertoens, Susanne Preiss, Pierre Debs, Nancy Noben-Trauth, and Thomas Blankenstein. "Generation of Tumor-associated Cytotoxic T Lymphocytes Requires Interleukin 4 from CD8+ T Cells." Journal of Experimental Medicine 194, no. 12 (2001): 1767–75. http://dx.doi.org/10.1084/jem.194.12.1767.

Full text
Abstract:
Activation of tumor-associated CD8+ cytotoxic T lymphocytes (CTLs) often requires antigen representation, e.g., by dendritic cells (DCs), and CD4+ T cell help. Previously, we showed that CTL-mediated tumor immunity required interleukin 4 (IL-4) during the immunization but not effector phase. To determine the source and target cells of IL-4, we performed adoptive T cell transfers using CD4+ and CD8+ T cells from IL-4−/− and IL-4R−/− mice and analyzed CTL generation. Even though necessary for CTL generation, CD4+ T cells did not need to express IL-4 or IL-4R. Surprisingly, CTL generation require
APA, Harvard, Vancouver, ISO, and other styles
26

Buelens, Christel, Valérie Verhasselt, Donat De Groote, Kris Thielemans, Michel Goldman, and Fabienne Willems. "Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin-4 and granulocyte/ macrophage-colony-stimulating factor." European Journal of Immunology 27, no. 3 (1997): 756–62. http://dx.doi.org/10.1002/eji.1830270326.

Full text
APA, Harvard, Vancouver, ISO, and other styles
27

Osugi, Yuko, Slavica Vuckovic, and Derek N. J. Hart. "Myeloid blood CD11c+ dendritic cells and monocyte-derived dendritic cells differ in their ability to stimulate T lymphocytes." Blood 100, no. 8 (2002): 2858–66. http://dx.doi.org/10.1182/blood.v100.8.2858.

Full text
Abstract:
Dendritic cells (DCs) initiate and direct immune responses. Recent studies have defined different DC populations, therefore we undertook this study comparing 2 types of myeloid DCs: blood CD11c+DCs and in vitro monocyte-derived DCs (Mo-DCs), which are both candidates as cellular adjuvants for cancer immunotherapy. Blood CD11c+ DCs were prepared by cell sorting from peripheral blood mononuclear cells cultured overnight in RPMI 1640 medium supplemented with autologous or pooled AB serum. Mo-DCs were prepared in the same medium using granulocyte macrophage–colony-stimulating factor (GM-CSF)/inter
APA, Harvard, Vancouver, ISO, and other styles
28

Feili-Hariri, Maryam, Dewayne H. Falkner, Andrea Gambotto, et al. "Dendritic Cells Transduced to Express Interleukin-4 Prevent Diabetes in Nonobese Diabetic Mice with Advanced Insulitis." Human Gene Therapy 14, no. 1 (2003): 13–23. http://dx.doi.org/10.1089/10430340360464679.

Full text
APA, Harvard, Vancouver, ISO, and other styles
29

Fresnay, Stéphanie, David E. Chalmers, Christophe Ferrand, et al. "Polybrene and interleukin-4: two opposing factors for retroviral transduction of bone-marrow-derived dendritic cells." Journal of Gene Medicine 4, no. 6 (2002): 601–12. http://dx.doi.org/10.1002/jgm.311.

Full text
APA, Harvard, Vancouver, ISO, and other styles
30

Delneste, Yves, Peggy Charbonnier, Nathalie Herbault та ін. "Interferon-γ switches monocyte differentiation from dendritic cells to macrophages". Blood 101, № 1 (2003): 143–50. http://dx.doi.org/10.1182/blood-2002-04-1164.

Full text
Abstract:
Abstract Human monocytes differentiate into dendritic cells (DCs) or macrophages according to the nature of environmental signals. Monocytes stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF) plus interleukin 4 (IL-4) yield DCs. We tested here whether interferon-γ (IFN-γ), a potent activator of macrophages, may modulate monocyte differentiation. Addition of IFN-γ to IL-4 plus GM-CSF–stimulated monocytes switches their differentiation from DCs to CD14−CD64+ macrophages. IFN-γ increases macrophage colony-stimulating factor (M-CSF) and IL-6 production by IL-4 plus GM-CSF–st
APA, Harvard, Vancouver, ISO, and other styles
31

Chen, Song, Ran Ding, Yan Zhou, Xian Zhang, Rui Zhu, and Xiang-Dong Gao. "Immunomodulatory Effects of Polysaccharide from Marine FungusPhoma herbarumYS4108 on T Cells and Dendritic Cells." Mediators of Inflammation 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/738631.

Full text
Abstract:
YCP, as a kind of natural polysaccharides from the mycelium of marine filamentous fungusPhoma herbarumYS4108, has great antitumor potentialviaenhancement of host immune response, but little is known about the molecular mechanisms. In the present study, we mainly focused on the effects and mechanisms of YCP on the specific immunity mediated by dendritic cells (DCs) and T cells. T cell /DC activation-related factors including interferon- (IFN-)γ, interleukin-12 (IL-12), and IL-4 were examined with ELISA. Receptor knock-out mice and fluorescence-activated cell sorting are used to analyze the YCP-
APA, Harvard, Vancouver, ISO, and other styles
32

Jiang, Xiao-Xia, Yi Zhang, Bing Liu, et al. "Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells." Blood 105, no. 10 (2005): 4120–26. http://dx.doi.org/10.1182/blood-2004-02-0586.

Full text
Abstract:
AbstractMesenchymal stem cells (MSCs), in addition to their multilineage differentiation, have a direct immunosuppressive effect on T-cell proliferation in vitro. However, it is unclear whether they also modulate the immune system by acting on the very first step. In this investigation, we addressed the effects of human MSCs on the differentiation, maturation, and function of dendritic cells (DCs) derived from CD14+ monocytes in vitro. Upon induction with granulocyte-macrophage colony-stimulating factor (GM-CSF) plus interleukin-4 (IL-4), MSC coculture could strongly inhibit the initial differ
APA, Harvard, Vancouver, ISO, and other styles
33

Moulin, Véronique, Fabienne Andris, Kris Thielemans, Charlie Maliszewski, Jacques Urbain, and Muriel Moser. "B Lymphocytes Regulate Dendritic Cell (Dc) Function in Vivo." Journal of Experimental Medicine 192, no. 4 (2000): 475–82. http://dx.doi.org/10.1084/jem.192.4.475.

Full text
Abstract:
Increasing evidence indicates that dendritic cells (DCs) are the antigen-presenting cells of the primary immune response. However, several reports suggest that B lymphocytes could be required for optimal T cell sensitization. We compared the immune responses of wild-type and B cell-deficient (μMT) mice, induced by antigen emulsified in adjuvant or pulsed on splenic dendritic cells. Our data show that lymph node cells from both control and μMT animals were primed, but each released distinct cytokine profiles. Lymph node T cells from control animals secreted interferon (IFN)-γ, interleukin (IL)-
APA, Harvard, Vancouver, ISO, and other styles
34

Mahnke, Karsten, Yingjie Qian, Jürgen Knop, and Alexander H. Enk. "Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells." Blood 101, no. 12 (2003): 4862–69. http://dx.doi.org/10.1182/blood-2002-10-3229.

Full text
Abstract:
AbstractCoupling of ovalbumin (OVA) to anti–DEC-205 monoclonal antibody (mAb) (αDEC) induced the proliferation of OVA-specific T cells in vivo. Expansion was short-lived, caused by dendritic cells (DCs), and rendered T cells anergic thereafter. Phenotypic analysis revealed the induction of CD25+/CTLA-4+ T cells suppressing proliferation and interleukin-2 (IL-2) production of effector CD4+ T cells. The findings were supported by 2 disease models: (1) CD4+ T-cell–mediated hypersensitivity reactions were suppressed by the injection of αDEC-OVA and (2) the application of hapten-coupled αDEC-205 re
APA, Harvard, Vancouver, ISO, and other styles
35

Yamada, Kazuhiko, Mitsunori Yamakawa, Yutaka Imai, and Masaru Tsukamoto. "Expression of Cytokine Receptors on Follicular Dendritic Cells." Blood 90, no. 12 (1997): 4832–41. http://dx.doi.org/10.1182/blood.v90.12.4832.

Full text
Abstract:
Abstract Follicular dendritic cells (FDCs) in the lymphoid follicle (LF) are essential to the sequential processes of B-cell proliferation, selection, and differentiation. Although the importance of some cytokines in these processes has been pointed out, there is little information about the follicular localization of their receptors. We investigated, with special reference to FDCs, the localization of cytokine receptors as well as cytokines themselves in human tonsils by several means, including immunochemistry, immunoelectron microscopy, reverse transcriptase polymerase chain reaction, and i
APA, Harvard, Vancouver, ISO, and other styles
36

Yamada, Kazuhiko, Mitsunori Yamakawa, Yutaka Imai, and Masaru Tsukamoto. "Expression of Cytokine Receptors on Follicular Dendritic Cells." Blood 90, no. 12 (1997): 4832–41. http://dx.doi.org/10.1182/blood.v90.12.4832.4832_4832_4841.

Full text
Abstract:
Follicular dendritic cells (FDCs) in the lymphoid follicle (LF) are essential to the sequential processes of B-cell proliferation, selection, and differentiation. Although the importance of some cytokines in these processes has been pointed out, there is little information about the follicular localization of their receptors. We investigated, with special reference to FDCs, the localization of cytokine receptors as well as cytokines themselves in human tonsils by several means, including immunochemistry, immunoelectron microscopy, reverse transcriptase polymerase chain reaction, and in situ hy
APA, Harvard, Vancouver, ISO, and other styles
37

Bouis, Deborah A., Taissia G. Popova, Akira Takashima, and Michael V. Norgard. "Dendritic Cells Phagocytose and Are Activated byTreponema pallidum." Infection and Immunity 69, no. 1 (2001): 518–28. http://dx.doi.org/10.1128/iai.69.1.518-528.2001.

Full text
Abstract:
ABSTRACT Cell-mediated immune processes play a prominent role in the clinical manifestations of syphilis, a sexually transmitted disease of humans caused by spirochetal bacterium Treponema pallidum. The immune cell type that initiates the early immune response toT. pallidum thus far has not been identified. However, dendritic cells (DCs) are the first immune-competent cells to encounter antigens within skin or mucous membranes, the principal sites of early syphilitic infection. In the present study, immature DC line XS52, derived from murine skin, was utilized to examine T. pallidum-DC interac
APA, Harvard, Vancouver, ISO, and other styles
38

Luczyński, Włodzimierz, Anna Stasiak-Barmuta, Elzbieta Iłendo, et al. "CD40 stimulation induces differentiation of acute lymphoblastic leukemia cells into dendritic cells." Acta Biochimica Polonica 53, no. 2 (2006): 377–82. http://dx.doi.org/10.18388/abp.2006_3352.

Full text
Abstract:
Despite the very high percentage of long-term remissions in acute lymphoblastic leukemia (ALL) in children, some of them suffer from recurrence of the disease. New treatment modalities, e.g. effective geno- and immunotherapy are needed. The use of neoplasmatic cells to present tumor antigens is one of the approaches in cancer vaccines. ALL cells lack the expression of costimulatory molecules and are poor antigen presenting cells (APCs) for T-cell activation. CD40/40L interaction stimulates B-cells to proliferate, differentiate, upregulate costimulatory molecules and increase antigen presentati
APA, Harvard, Vancouver, ISO, and other styles
39

Sarkar, Sujata, Laura A. Tesmer, Vindhya Hindnavis, Judith L. Endres, and David A. Fox. "Interleukin-17 as a molecular target in immune-mediated arthritis: Immunoregulatory properties of genetically modified murine dendritic cells that secrete interleukin-4." Arthritis & Rheumatism 56, no. 1 (2006): 89–100. http://dx.doi.org/10.1002/art.22311.

Full text
APA, Harvard, Vancouver, ISO, and other styles
40

Strunk, D., K. Rappersberger, C. Egger, et al. "Generation of human dendritic cells/Langerhans cells from circulating CD34+ hematopoietic progenitor cells." Blood 87, no. 4 (1996): 1292–302. http://dx.doi.org/10.1182/blood.v87.4.1292.bloodjournal8741292.

Full text
Abstract:
Human Langerhans cells (LC) are CD1a+ dendritic cells (DC) that function as potent antigen-presenting cells for primary and secondary immune responses. Limitations in DC/LC numbers, imposed by difficult and tedious isolation procedures, have so far precluded their use as immunogens in the generation and/or augmentation of host responses against various pathogens. Therefore, we have developed a procedure for the generation of human DC/LC from CD34+ hematopoietic progenitor cells (HPC) isolated (mean: 0.7 x 10(6)/ buffy coat and 2.6 x 10(6)/leukapheresis product) and purified ( > 95%) from th
APA, Harvard, Vancouver, ISO, and other styles
41

CAO, Weiping, Szu Hee LEE, and Jinhua LU. "CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells." Biochemical Journal 385, no. 1 (2004): 85–93. http://dx.doi.org/10.1042/bj20040741.

Full text
Abstract:
Human DCs (dendritic cells) express surface CD83 upon activation. Comparing the surface induction of CD83 with the upregulation of CD40, CD80 and CD86 during LPS (lipopolysaccharide)-induced DC maturation showed that CD83 induction occurred more rapidly. Despite the lack of CD83 on immature DCs, it was detected in these cells by Western blotting and flow cytometry. Indirect immunofluorescence revealed CD83 inside immature DCs in perinuclear regions. CD83 was absent on monocytes and macrophages, but it was detected inside these cells and found to be rapidly surface-expressed upon LPS-induced ac
APA, Harvard, Vancouver, ISO, and other styles
42

Cheng, Wei, Tian-tian Yu, Ai-ping Tang, Ken He Young, and Li Yu. "Blastic Plasmacytoid Dendritic Cell Neoplasm: Progress in Cell Origin, Molecular Biology, Diagnostic Criteria and Therapeutic Approaches." Current Medical Science 41, no. 3 (2021): 405–19. http://dx.doi.org/10.1007/s11596-021-2393-3.

Full text
Abstract:
SummaryBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy characterized by recurrent skin nodules, an aggressive clinical course with rapid involvement of hematological organs, and a poor prognosis with poor overall survival. BPDCN is derived from plasmacytoid dendritic cells (pDCs) and its pathogenesis is unclear. The tumor cells show aberrant expression of CD4, CD56, interleukin-3 receptor alpha chain (CD123), blood dendritic cell antigen 2 (BDCA 2/CD303), blood dendritic cell antigen 4 (BDCA4) and transcription factor (E protein) E2-2 (TCF4). The best tr
APA, Harvard, Vancouver, ISO, and other styles
43

Cheng, Pingyan, Yulia Nefedova, Lucio Miele, Barbara A. Osborne, and Dmitry Gabrilovich. "Notch signaling is necessary but not sufficient for differentiation of dendritic cells." Blood 102, no. 12 (2003): 3980–88. http://dx.doi.org/10.1182/blood-2003-04-1034.

Full text
Abstract:
Abstract The Notch family of receptors plays an important role in regulation of cell differentiation via direct contact between hematopoietic progenitor cells (HPCs) and bone marrow stroma (BMS). However the precise contribution of Notch in dendritic cell (DC) differentiation is controversial. In 2 different experimental systems using Notch-1–null embryonic stem cells and Notch-1–deficient HPCs we have found that Notch-1 is necessary for DC differentiation. However, activation of Notch-1 and Notch-2 with cell-bound Notch ligand did not result in differentiation of mature DCs or macrophages. In
APA, Harvard, Vancouver, ISO, and other styles
44

Gray, Christian P., Paolo Arosio, and Peter Hersey. "Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells." Blood 99, no. 9 (2002): 3326–34. http://dx.doi.org/10.1182/blood.v99.9.3326.

Full text
Abstract:
Abstract Heavy chain ferritin (H-ferritin) is a component of the iron-binding protein, ferritin. We have previously shown that H-ferritin inhibits anti-CD3–stimulated lymphocyte proliferation and that this was due to increased production of interleukin-10 (IL-10). In the present study we have shown that induction of IL-10 production was due to effects of H-ferritin on adherent antigen-presenting cells (APCs) in blood and monocyte-derived dendritic cells (MoDCs). IL-10 was produced by a subpopulation of CD4 T cells, which expressed the CD25 component of the IL-2 receptor and the CTLA-4 receptor
APA, Harvard, Vancouver, ISO, and other styles
45

Ito, Tomoki, Maria Yang, Yui-Hsi Wang, et al. "Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand." Journal of Experimental Medicine 204, no. 1 (2007): 105–15. http://dx.doi.org/10.1084/jem.20061660.

Full text
Abstract:
Although there is evidence for distinct roles of myeloid dendritic cells (DCs [mDCs]) and plasmacytoid pre-DCs (pDCs) in regulating T cell–mediated adaptive immunity, the concept of functional DC subsets has been questioned because of the lack of a molecular mechanism to explain these differences. In this study, we provide direct evidence that maturing mDCs and pDCs express different sets of molecules for T cell priming. Although both maturing mDCs and pDCs upregulate the expression of CD80 and CD86, only pDCs upregulate the expression of inducible costimulator ligand (ICOS-L) and maintain hig
APA, Harvard, Vancouver, ISO, and other styles
46

Hamdi, Haifa, Véronique Godot, Marie-Christine Maillot, et al. "Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper." Blood 110, no. 1 (2007): 211–19. http://dx.doi.org/10.1182/blood-2006-10-052506.

Full text
Abstract:
Dendritic cells (DCs) determine whether antigen presentation leads to immune activation or to tolerance. Tolerance-inducing DCs (also called regulatory DCs) act partly by generating regulatory T lymphocytes (Tregs). The mechanism used by DCs to switch toward regulatory DCs during their differentiation is unclear. We show here that human DCs treated in vitro with glucocorticoids produce the glucocorticoid-induced leucine zipper (GILZ). Antigen presentation by GILZ-expressing DCs generates CD25highFOXP3+CTLA-4/CD152+ and interleukin-10–producing Tregs inhibiting the response of CD4+ and CD8+ T l
APA, Harvard, Vancouver, ISO, and other styles
47

Boontham, Pisake, Adrian Robins, Palanichamy Chandran, et al. "Significant immunomodulatory effects of Pseudomonas aeruginosa quorum-sensing signal molecules: possible link in human sepsis." Clinical Science 115, no. 11 (2008): 343–51. http://dx.doi.org/10.1042/cs20080018.

Full text
Abstract:
Pathogenic bacteria use quorum-sensing signal molecules to co-ordinate the expression of virulence genes. Animal-based studies have demonstrated the immunomodulatory effects of quorum-sensing signal molecules. In the present study, we have examined the impact of these molecules on normal human immune function in vitro and compared this with immune changes in patients with sepsis where quorum-sensing signal molecules were detected in the sera of patients. Quorum-sensing signal molecules inhibited normal dendritic cell and T-cell activation and proliferation, and down-regulated the expression of
APA, Harvard, Vancouver, ISO, and other styles
48

Laudanski, Krzysztof, Meng Qing, Hanna Oszkiel, et al. "Ketamine Affects In Vitro Differentiation of Monocyte into Immature Dendritic Cells." Anesthesiology 123, no. 3 (2015): 628–41. http://dx.doi.org/10.1097/aln.0000000000000783.

Full text
Abstract:
Abstract Background: Monocytes (MOs) have the unique ability to differentiate into immature dendritic cells (iDCs) (MO→iDC) under the influence of interleukin-4 and granulocyte–monocyte colony-stimulating factor (IL-4&GM-CSF). In this study, the authors investigated the influence of ketamine on the process of MO→iDC. Methods: iDCs were cultured from MO obtained from 36 subjects in the presence of IL-4 and GM-CSF and ketamine at 100, 10, and 1 μg/ml for 5 days. In some of the experiments, the authors used nonspecific N-methyl-d-aspartate (NMDA) receptor antagonist MK-801, NMDA, or a neutral
APA, Harvard, Vancouver, ISO, and other styles
49

Liau, Linda M., Keith L. Black, Robert M. Prins, et al. "Treatment of intracranial gliomas with bone marrow—derived dendritic cells pulsed with tumor antigens." Journal of Neurosurgery 90, no. 6 (1999): 1115–24. http://dx.doi.org/10.3171/jns.1999.90.6.1115.

Full text
Abstract:
Object. An approach toward the treatment of intracranial gliomas was developed in a rat experimental model. The authors investigated the ability of “professional” antigen-presenting cells (dendritic cells) to enhance host antitumor immune responses when injected as a vaccine into tumor-bearing animals.Methods. Dendritic cells, the most potent antigen-presenting cells in the body, were isolated from rat bone marrow precursors stimulated in vitro with granulocyte—macrophage colony-stimulating factor (GM-CSF) and interleukin-4. Cultured cell populations were confirmed to be functional antigen-pre
APA, Harvard, Vancouver, ISO, and other styles
50

Montagna, Daniela, Rita Maccario, Franco Locatelli, et al. "Ex vivo priming for long-term maintenance of antileukemia human cytotoxic T cells suggests a general procedure for adoptive immunotherapy." Blood 98, no. 12 (2001): 3359–66. http://dx.doi.org/10.1182/blood.v98.12.3359.

Full text
Abstract:
Abstract Adoptive cellular immunotherapy has proven to be a successful approach in preventing and curing cytomegalovirus infection and Epstein-Barr virus–associated lymphomas after bone marrow transplantation. Translation of this approach for preventing leukemia relapse after bone marrow transplantation might require ex vivo priming and long-term maintenance of leukemia blast-specific T cells. To accomplish this goal, procedures were optimized for the in vitro priming of naive CD8 using dendritic cells activated by CD40 ligation, interleukin-12 (IL-12), and IL-7. Using T lymphocytes and dendri
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography