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Dissertations / Theses on the topic 'Dengue viruses'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 January 2023

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1

Li, Mingyuan, and 李明圓. "Molecular dissection of dengue virus egress : involvement of host cellular factors-KDEL receptors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208011.

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The life cycle of enveloped viruses is a complex process relying on specific interactions with host factors that, in turn, represent potential targets for interfering with viral replication and pathogenesis. Although the molecular identity of cellular receptors involved in virion entry has been established for many viruses, few studies have investigated whether host proteins on intracellular compartments may function as receptors to facilitate viral trafficking and release from infected cells. In particular, viral-host interactions during dengue virus (DENV) egress are still poorly characteriz

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2

Bletchly, Cheryl. "Antigenic and structural analysis of the NS1 glycoprotein of dengue virus /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16420.pdf.

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3

Lo, Chung-yan Joanne, and 羅頌恩. "Characterization by electron microscopy of dengue virus egress using dengue recombinant subviral particle (RSPs) as a model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48330115.

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Dengue is the most common mosquito-borne human disease, leading to 2.5 billion people at risk, 50-100 millions infections each year worldwide and among them, 500 000 severe dengue cases (dengue hemorrhagic fever, DHF/ dengue shock syndrome, DSS) plus more than 20 000 deaths. It can be caused by any of four dengue virus serotypes, which are antigenicly distinct and belong to the Flaviviridae family, genus Flavivirus. However, up till now there is no specific drug and vaccine against dengue. Understanding mechanisms developed by dengue virus to exploit host cells during all stages of the replic

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4

Warke, Rajas V. "Activation of TNF alpha, IL1-beta and Type-i IFn pathways in human umbilical vein endothelial cells during dengue 2 virus infection." Link to electronic thesis, 2002. http://www.wpi.edu/Pubs/ETD/Available/etd-0424102-141341.

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5

Bhatia, Kanika Devi. "The role of mononuclear phagocytes in dengue immunopathogenesis /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17170.pdf.

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6

Lambeth, Cassandra Rashida De Silva Aravinda Manu. "Interactions between dengue type 3 viruses and human dendritic cells." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1238.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology in the School of Medicine." Discipline: Microbiology and Immunology; Department/School: Medicine.

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7

Serafin, Ina Loretta. "Epitope mapping of the dengue 3 envelope protein." Thesis, Queensland University of Technology, 1999.

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8

Brown, Jennifer L. "A molecular and immunological investigation of cellular responses to dengue virus identification of potentially upregulated host genes and the constructionof a vaccinia virus expressing the dengue 1 Hawaii NS3 protein." Link to electronic version, 2000. http://www.wpi.edu/Pubs/ETD/Available/etd-0330100-124248/.

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9

Matusan, Anita Esther 1973. "Mutational analysis of the proteinase and helicase regions of the Dengue virus type 2 NS3 protein." Monash University, Dept. of Microbiology, 2001. http://arrow.monash.edu.au/hdl/1959.1/8339.

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10

Kudelko, Mateusz Aleksander. "Characterization of a novel role for class-II ADP-ribosylation factorsin the regulation of dengue egress using newly developed recombinantsubviral particles." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46455620.

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11

Choi, Wai-yee Junet. "Serum neopterin for early assessment of severity of severe acute respiratory syndrome and Dengue virus infection." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B32031579.

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12

Enguehard, Margot. "Interaction between chikungunya and dengue viruses during co-infection in Aedes mosquito cells and in Aedes aegypti mosquito." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1161/document.

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Au cours des dernières années, de nombreuses épidémies ont emergé ou ré émergé, et sont causées par des arbovirus (arthropod-borne viruses), des virus transmis à des vertébrés par des insectes piqueurs vecteurs. Avec l'augmentation de la densité humaine dans certaines zones géographiques et le réchauffement climatique qui contribuent à l'expansion géographique des vecteurs, les maladies induites par ces virus (arboviroses) ont un impact de plus en plus important sur la santé humaine et l'économie mondiale. Il est donc déterminant d'augmenter nos connaissances sur les systèmes mis en jeux pour

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13

Beasley, David Wayne Colin. "Identification of functional epitopes on dengue 1 environs." Thesis, Queensland University of Technology, 1999.

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14

Brown, Jennifer L. "A Molecular and Immunological Investigation of Cellular Responses to Dengue Virus: Identification of Potentially Upregulated Host Genes and the Construction of a Vaccinia Virus Expressing the Dengue 1 Hawaii NS3 Protein." Digital WPI, 2000. https://digitalcommons.wpi.edu/etd-theses/187.

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The purpose of this thesis for the degree of Master of Science was to use molecular and immunological techniques to study cellular responses to dengue virus infection. In the initial study, Differential Display was used to compare mRNA expression in dengue-infected K562 cells and mock-infected cells. Cloning and sequencing were then used to identify cellular genes that were potentially up-regulated in response to Dengue virus infection. These genes included bleomycin hydrolase and a dystrophin homologue. The goal of the later part of this research was to construct a recombinant vaccini

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15

Murphy, Amanda. "Eco-epidemiology of dengue and Ross River viruses across rural and urban environments." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/204283/1/Amanda_Murphy_Thesis.pdf.

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This research investigated the epidemiology and ecology of two mosquito-borne viruses of public health importance in the Asia-Pacific: dengue and Ross River viruses. Patterns of disease caused by these two viruses were analysed in space and time across rural and urban settings, and some of the influencing demographic, geographic and environmental factors were explored. The outcomes of this research included increased understanding of the complex influences on mosquito-borne virus transmission in different human habitats, and the development of unique field and lab-based approaches for studying

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16

Choi, Wai-yee Junet, and 蔡偉儀. "Serum neopterin for early assessment of severity of severe acute respiratory syndrome and Dengue virus infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B32031579.

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17

Choudhury, Md Abu Hasnat Zamil. "Population Dynamics of RNA viruses." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/60866/1/Md._Choudhury_Thesis.pdf.

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Between 50 and 100 million people are infected with dengue viruses each year and more than 100,000 of these die. Dr Choudhury has demonstrated that populations of dengue viruses in individual patients are genetically and functionally very diverse and that this diversity changes significantly at the time of major outbreaks of disease. The results of his studies may inform strategies which will make dengue vaccines far more effective.

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18

Warke, Rajas V. "Molecular Dissection of the Cellular Reponse to Dengue Virus Infection." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/366.

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The immune response to viral infection involves a complexity of both innate and adaptive pathways at the cellular and the molecular level. There are many approaches to begin to define the pathways at work to control viral pathogenesis. The approach favored in this thesis was to conduct a broad screen of the innate immune response at the gene expression level of infected cells. The innate immune response is critical to the control of viral infections. Type I interferons (IFN), IFNα and IFNβ, are antiviral proteins that are an integral part of the innate immune response. Furthermore, by virtue o

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19

Collins, Jacob M. "Transcriptional Regulation of the Interleukin-8 Promoter by Multiple Dengue Viral Proteins: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/616.

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Dengue virus (DENV) causes over 500,000 infections annually with a spectrum of clinical diseases ranging from subclinical infection to dengue, a mild febrile illness, to life-threatening severe dengue. Vascular leakage without endothelial cell damage is the hallmark symptom of severe dengue illness and is proposed to be directly mediated by soluble inflammatory mediators IL-8 and TNFα. IL-8 production occurs in response to DENV infection, is elevated during severe dengue, is proposed to inhibit interferon, and could potentially recruit target cells to sites of infection. We previously showed t

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20

Ostrout, Nicholas D. "Vaccinia and Dengue Viruses: Exploring Current Fundamental Issues of Memory T Cells and Utilizing Comparative Quantitative Immunology to Compare Correlates of Protection Following Smallpox Immunization." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1205938117.

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21

Tricou, Vianney M. "Dengue diagnostics and therapeutic interventions in Viet Nam." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:46dfff8c-f7d2-4c43-b053-a5438531290a.

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Dengue is a major public health problem that affects tens of millions of people annually in tropical and sub-tropical countries. This acute viral infection happens to be severe and even life threatening but there is still no available drug or vaccine. Previous studies have noted early higher viral burden in patients who develop more severe symptoms suggesting that administration of a potent and safe antiviral may prevent progression to severe dengue. To verify this hypothesis, we have conducted the first RCT directed towards reducing the viral burden in vivo by administrating chloroquine (CQ),

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22

Mathew, Anuja. "Human T Cell Responses to Dengue Virus Infections: CD8+CTL and Acute Immunosuppression: a Dissertation." eScholarship@UMMS, 1999. https://escholarship.umassmed.edu/gsbs_diss/18.

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There are four serotypes of dengue virus designated dengue 1, 2, 3 and 4 (D1, D2, D3 and D4) and epidemiological studies indicate that a severe complication of dengue virus infection - dengue hemorrhagic fever (DHF) is more likely to occur following a secondary infection. DHF is hypothesized to be immunologically mediated and may be triggered by virus-specific T cells. It is also likely that dengue virus-specific cytotoxic T lymphocytes (CTLs) are important for recovery from dengue virus infections. An analysis of the immune response during acute illness and when the patient has recovered from

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23

Nightingale, Zachary Davis. "Distinct Behaviors of Infected and Bystander Dendritic Cells Following Exposure to Dengue Virus: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/361.

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Dengue viruses (DV) are re-emerging mosquito-borne pathogens for which four distinct lineages, grouped based on serology and referred to as serotypes 1-4 (DIV-D4V), have been described. Epidemiological data imply that re-infection with a "heterologous" serotype, i.e, one other than that to which the individual was originally exposed, enhances the risk for development of severe disease, dengue hemorrhagic fever (DHF). The hallmark of DHF is a transient capillary leakage syndrome of rapid onset, temporally associated with the resolution of fever and viremia. In its most grave form, the vascular

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24

Friberg-Robertson, Heather L. "CD8+ T Cell Serotype-Cross-Reactivity is a Predominant Feature of Dengue Virus Infections in Humans: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/513.

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The four serotypes of dengue virus (DENV 1-4) have a significant and growing impact on global health. Dengue disease encompasses a wide range of clinical symptoms, usually presenting as an uncomplicated febrile illness lasting 5-7 days; however, a small percentage of infections are associated with plasma leakage and bleeding tendency (called dengue hemorrhagic fever, DHF), which can result in shock. Epidemiological studies indicate that severe dengue disease most often occurs during secondary heterotypic DENV infection. Additionally, plasma leakage (the hallmark of DHF) coincides with deferves

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25

Ekwudu, O'mezie. "Diversity of arthropod-borne viruses and implications for Wolbachia-based biocontrol." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/127159/1/O%27mezie_Ekwudu_Thesis.pdf.

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This research examines the impact of genetic diversity in dengue virus (DENV) on incubation period in vector mosquitoes, and on Wolbachia, a novel vector biocontrol agent. It also extends the DENV study to other flaviviruses (Zika and West Nile - Kunjin) and alphaviruses (Barmah Forest, Ross River and Sindbis) to provide evidence as to whether a heat-resistant strain of Wolbachia, wAlbB, can be used to suppress the transmission of these mosquito-borne viruses. The research outcomes show that viral genetic variation is reflected in transmission kinetics of DENV. Data from the Wolbachia experime

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26

Chepkorir, Edith. "Assessing the risk of Transmission of Yellow Fever and Dengue viruses by Aedes (Stegomyia) mosquito populations in Northern Kenya." Thesis, University of Pretoria, 2019. http://hdl.handle.net/2263/75861.

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East Africa has been experiencing an increase in the occurrence of emerging infectious diseases such as yellow fever (YF) and dengue (DEN). Increasing frequency of YF activity in East Africa constitutes a re-emergence that was not detected for over 40 years. Additionally, DEN outbreaks have also increased in frequency and continue to be detected in Kenya and in neighboring countries like Tanzania, Somalia, Djibouti, Eritrea and South Sudan. The renewed vigor of YF and dengue fever (DF) re-emergence in East Africa presents a new challenge to public health in spite of the availability of a safe

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27

Medin, Carey L. "Chemokine Induction by Dengue Virus Infection: Mechanisms and the Role of Viral Proteins: a Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/30.

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The focus of this thesis is the role of dengue virus in the induction of chemokines. Dengue virus (DENV) occurs as four distinct serotypes, called DENV 1,2,3,and 4. Symptomatic DENV infection ranges from a self limited febrile illness, dengue fever (DF), to a more severe disease, dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). DHF is characterized by increased capillary permeability resulting in decreased plasma volume, which may be accompanied by hemorrhagic manifestations. Many factors including T cell cross reactivity, viral burden, antibody dependent enhancement and induction of

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28

Pickett, Brett E. "The contribution of different mechanisms of viral sequence variation to the evolution of positive-sense single-stranded RNA viruses." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2010. https://www.mhsl.uab.edu/dt/2010p/pickett.pdf.

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29

Girmann, Mirko [Verfasser], and Jürgen [Akademischer Betreuer] May. "Seroprevalence of Antibodies against Chikungunya, Dengue and Rift Valley Fever Viruses after Febrile Illness Outbreak, Madagascar / Mirko Girmann. Betreuer: Jürgen May." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2014. http://d-nb.info/1051435625/34.

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30

Luppino, Plinio Luis. "Detecção do vírus dengue pela técnica de aglutinação do látex modelo experimental." Faculdade de Medicina de São José do Rio Preto, 2007. http://bdtd.famerp.br/handle/tede/21.

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Made available in DSpace on 2016-01-26T12:51:14Z (GMT). No. of bitstreams: 1 plinioluisluppino_tese.pdf: 1297185 bytes, checksum: 89ac3b7475f1bfd00a6808afd1ba661e (MD5) Previous issue date: 2007-06-04<br>Dengue is the arthropod-borne transmitted viral disease of highest worldwide prevalence in mortality and morbidity. The proportion is pandemic ranging 1.6 million of infected patients yearly. Clinical presentation associated to epidemiological factors such as dengue prevalence in the patient s origin have been the only mean for early diagnosis. Laboratorial diagnosis, the conclusive, require

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31

Sayce, Andrew Cameron. "Iminosugars as dengue virus therapeutics : molecular mechanisms of action of a drug entering clinical trials." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8d4da0ce-bfa6-447d-a280-630479f898af.

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Iminosugars are a class of small molecules defined by substitution of a sugar’s ring oxygen with nitrogen. Various chemical modifications of these basic structures (e.g. alkyl chain addition off of the ring nitrogen) have been developed during the last several decades. These molecules have been considered as therapeutics for a number of pathologies including viral infection, congenital disorders of glycosylation (of both glycoproteins and glycolipids), and diabetes. This thesis focuses on the application of a small subset of iminosugars, known as deoxynojirimycin derivatives, as therapeutics a

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32

Bashyam, Hema Sundara. "Serotype Cross-Reactive CD8+ T Cell Response to Heterologous Secondary Dengue Virus Infections in Humans: a Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/258.

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The generation of memory T cells following primary exposure to a pathogen is a critical feature of the vertebrate immune system which has evolved as a protective mechanism in order to defend the host against repeated assaults by the patnogen. Memory T cells are long-lived, undergo rapid proliferation upon re-activation, mediate a robust secondary response and clear the pathogen much more efficiently. These aspects have made the generation of memory T cells an attractive goal for the production of both prophylactic and therapeutic vaccines. However, the degeneracy of the T cell receptor, whereb

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33

Alves, Beatriz Santos Capela. "Caracterização das proteinas humanas Mov34 e PACT e analise da sua interação com o RNA do virus da dengue." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317180.

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Orientador: Nilson Ivo Tonin Zanchin<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-11T18:49:26Z (GMT). No. of bitstreams: 1 Alves_BeatrizSantosCapela_D.pdf: 5512305 bytes, checksum: 707ea6299bc24ddc6fb459520d79aeee (MD5) Previous issue date: 2008<br>Resumo: O combate à dengue atualmente está limitado praticamente aos esforços de eliminação do mosquito transmissor, o Aedes aegypti, porém esta estratégia não tem se mostrado eficiente. O desenvolvimento de novos instrumentos de combate à dengue requer, portanto, maior conhe

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34

Beaumier, Coreen Michele. "Cross-Reactive Memory CD4⁺ and CD8⁺ T Cells Alter the Immune Response to Heterologous Secondary Dengue Virus Infections in Mice: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/350.

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Dengue virus (DENV) infects 50-100 million people worldwide every year and is the causative agent of dengue fever (DF) and the more severe dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). There are four genetically and immunologically distinct DENV serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). Evidence suggests that an increased risk for DHF/DSS during secondary infection with a heterologous DENV serotype is due to an immunopathological response mediated by serotype-cross-reactive memory T cells from the primary infection. Furthermore, epidemiological studies have shown that the seq

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35

Tiew, Kok-Chuan. "Dengue virus protease inhibitors." Thesis, Wichita State University, 2011. http://hdl.handle.net/10057/6117.

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Dengue virus (DENV) is a major health threat that affects 2.5 billion people, or 40% of the world’s population. However, there are no approved antiviral drugs or vaccines to treat Dengue infection. This thesis describes the design, synthesis and discovery of a new class of inhibitors of DENV NS3 protease. Structure-activity relationship studies have been carried out in order to delineate the structural elements responsible for the activity of this series of compounds. A lead compound suitable for further development has been identified.<br>Thesis (M.S.)--Wichita State University, College of Li

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36

Tison, Laurence. "La dengue." Bordeaux 2, 1995. http://www.theses.fr/1995BOR2P091.

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37

Lindegren, Gunnel. "Optimisation of dengue diagnostic tools in order to increase the knowledge of the pathogenesis." Stockholm : Department of Microbiology, Karolinska Institutet, 2008. http://diss.kib.ki.se/2008/978-91-7409-129-8/.

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38

Aravapalli, Sridhar. "Dengue virus and West Nile virus protease inhibitors." Diss., Wichita State University, 2013. http://hdl.handle.net/10057/6719.

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Dengue virus and West Nile virus are important mosquito-borne pathogens of Flaviviridae family affecting millions of people worldwide and causing a severe global healthcare threat. However, currently there are no approved effective antiviral drugs or vaccines available for the treatment of virus infection. This thesis describes the design, synthesis and discovery of two novel classes of reversible competitive inhibitors of Dengue Virus and West Nile Virus NS2B/NS3 protease. Structure-activity relationship studies have led to the identification of a low micromolar hit, which will be used in a h

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39

Tran, Tuan Anh. "Screening against the dengue virus polymerase." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4006.

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La dengue, une des maladies les plus largement émergents actuellement, avec 390 millions d'infections chaque année (OMS), est causée par le virus de la dengue contre lequel il n’existe pas de traitements. La protéine NS5 a un rôle important dans le cycle de réplication. Cette protéine se compose d'une méthionine S-transférase d’adénosyl en N-terminal et une ARN polymérase dépendante de l'ARN (RdRp) en C-terminal. Cette NS5 RdRp peut catalyser non seulement la synthèse du brin négatif de l'ARN, utilisé comme matrice pour synthétiser l'ARN brin plus-supplémentaire, mais aussi pour la synthèse d'

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40

He, Runtao. "Characterization of dengue virus envelope protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24745.pdf.

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41

Schaar, Hilde van der. "Cell entry mechanisms of dengue virus." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2009. http://irs.ub.rug.nl/ppn/318.

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42

Thu, Hlaing Myat. "Virus diversity and the emergence of Dengue." Thesis, Queensland University of Technology, 2004. https://eprints.qut.edu.au/16081/1/Hlaing_Myat_Thu_Thesis.pdf.

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The aims of this study were to investigate the role of the diversity of dengue virus populations in changing patterns of virus transmission and disease. Prior to the commencement of this study, dengue 2 virus (DENV-2) had been associated most frequently with severe disease, so the study commenced with this serotype. Because it was not possible to quantitate diversity in the entire 11 kb of the viral genome, the study focussed on the envelope (E) gene, because the E protein is the major protein on the surface of the virion and thus might be under strong selective pressure from the host immune s

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Thu, Hlaing Myat. "Virus Diversity and the Emergence of Dengue." Queensland University of Technology, 2004. http://eprints.qut.edu.au/16081/.

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The aims of this study were to investigate the role of the diversity of dengue virus populations in changing patterns of virus transmission and disease. Prior to the commencement of this study, dengue 2 virus (DENV-2) had been associated most frequently with severe disease, so the study commenced with this serotype. Because it was not possible to quantitate diversity in the entire 11 kb of the viral genome, the study focussed on the envelope (E) gene, because the E protein is the major protein on the surface of the virion and thus might be under strong selective pressure from the host immune s

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44

Patramool, Sirilaksana. "Interactions virus (dengue)-vecteurs (aedes) et mise en évidence d'une méthode d'isolement des virus de la dengue et du chikungunya." Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20139.

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La dengue et le chikungunya sont deux arboviroses émergentes qui sont transmises à l'homme par la piqûre de moustiques du genre Aedes. Il n'existe ni vaccin ni traitements commercialisés pour ces arboviroses. Il apparaît donc nécessaire de développer de nouvelles stratégies pour isoler les virus circulants et bloquer leur transmission. La compréhension des mécanismes mis en jeu dans les cellules des vecteurs Aedes lors d'une infection par le virus de la dengue (DENV) sont encore très peu étudiés, notamment pour les sérotypes 1 et 3. Par des analyses protéomiques de l'infection d'une lignée cel

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45

Hacker, Kari Ema De Silva Aravinda Manu. "Characterization of dengue virus interactions with host cells." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2845.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Jun. 4, 2010). "... in partial fulfillment of the degree of Doctor of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.

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46

Katri, Patricia. "Modeling the Transmission Dynamics of the Dengue Virus." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/417.

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Dengue (pronounced den'guee) Fever (DF) and Dengue Hemorrhagic Fever (DHF), collectively known as "dengue," are mosquito-borne, potentially mortal, flu-like viral diseases that affect humans worldwide. Transmitted to humans by the bite of an infected mosquito, dengue is caused by any one of four serotypes, or antigen-specific viruses. In this thesis, both the spatial and temporal dynamics of dengue transmission are investigated. Different chapters present new models while building on themes of previous chapters. In Chapter 2, we explore the temporal dynamics of dengue viral transmission by

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Wangteeraprasert, Apirath. "CD8+ T-cells responses in Dengue virus infection." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39398.

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Dengue virus, which has four serotypes, has several clinical manifestations including asymptomatic infection, a self-limiting febrile illness termed dengue fever (DF) and a severe form characterized by plasma leakage termed dengue hemorrhagic fever (DHF). The pathogenesis of DHF is not fully understood and many studies have shown that it is more prevalent during secondary infection. In addition to a mechanism termed antibody dependent enhancement (ADE), the role of T-cells in the pathogenesis of dengue also has been investigated. It has been hypothesized that upon secondary infection dengue-sp

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48

Twiddy, Sally Susanna. "The molecular epidemiology and evolution of dengue virus." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269490.

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Xu, Yongtao. "Computational design of peptide inhibitors for dengue virus." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603298.

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Fusion process is known to be the initial step of viral infection and hence targeting the entry process is a promising strategy to design antiviral therapy. The self-inhibitory peptides derived from the envelope (E) proteins function to inhibit the protein-protein interactions in the membrane fusion step mediated by the viral E proteins. Thus, they have the potential to be developed into effective antiviral therapy. We developed a Monte Carlo-based computational method with the aim to identify and optimize potential peptide hits from the E proteins. Some novel peptides may inhibit the protein-

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Lin, Yu-Ying, and 林育瑩. "Dengue Viruses Inhibit Mosquito JAK-STAT Signaling." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/pbqwtx.

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碩士<br>國防醫學院<br>微生物及免疫學研究所<br>101<br>Dengue fever is a mosquito-borne disease endemic in many countries of the world including Taiwan. This disease is transmitted the dengue virus by Aedes aegypti and Aedes albopictus female mosquito biting to human host. These two mosquito species are prevalent in Taiwan, with Aedes aegypti present only in southern location. Mosquito does not have the adaptive immunity as mammals, only exist the innate immunity to struggle against microbe such as virus. The dengue virus is circulated between the mosquito vector and human being; it might develop some strategy t

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