Journal articles: 'Dengue viruses'

1

Aaskov, John. "Dengue viruses." Pathology 25 (1993): 19. http://dx.doi.org/10.1016/s0031-3025(16)35773-7.

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Henchal, E. A., and J. R. Putnak. "The dengue viruses." Clinical Microbiology Reviews 3, no. 4 (October 1990): 376–96. http://dx.doi.org/10.1128/cmr.3.4.376.

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Dengue, a major public health problem throughout subtropical and tropical regions, is an acute infectious disease characterized by biphasic fever, headache, pain in various parts of the body, prostration, rash, lymphadenopathy, and leukopenia. In more severe or complicated dengue, patients present with a severe febrile illness characterized by abnormalities of hemostasis and increased vascular permeability, which in some instances results in a hypovolemic shock. Four distinct serotypes of the dengue virus (dengue-1, dengue-2, dengue-3, and dengue-4) exist, with numerous virus strains found worldwide. Molecular cloning methods have led to a greater understanding of the structure of the RNA genome and definition of virus-specific structural and nonstructural proteins. Progress towards producing safe, effective dengue virus vaccines, a goal for over 45 years, has been made.

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Henchal, E. A., and J. R. Putnak. "The dengue viruses." Clinical Microbiology Reviews 3, no. 4 (1990): 376–96. http://dx.doi.org/10.1128/cmr.3.4.376-396.1990.

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Tuiskunen Bäck, Anne, and Åke Lundkvist. "Dengue viruses – an overview." Infection Ecology & Epidemiology 3, no. 1 (January 2013): 19839. http://dx.doi.org/10.3402/iee.v3i0.19839.

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Vasilakis, N., J. Cardosa, M. Diallo, A. A. Sall, E. C. Holmes, K. A. Hanley, S. C. Weaver, J. Mota, and R. Rico-Hesse. "Sylvatic Dengue Viruses Share the Pathogenic Potential of Urban/Endemic Dengue Viruses." Journal of Virology 84, no. 7 (March 8, 2010): 3726–28. http://dx.doi.org/10.1128/jvi.02640-09.

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Gubler, Duane J. "Cities spawn epidemic dengue viruses." Nature Medicine 10, no. 2 (February 2004): 129–30. http://dx.doi.org/10.1038/nm0204-129.

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Aaskov, John, Katie Buzacott, Emma Field, Kym Lowry, Alain Berlioz-Arthaud, and Edward C. Holmes. "Multiple recombinant dengue type 1 viruses in an isolate from a dengue patient." Journal of General Virology 88, no. 12 (December 1, 2007): 3334–40. http://dx.doi.org/10.1099/vir.0.83122-0.

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Between 2000 and 2004, dengue virus type 1 (DENV-1) genotypes I and II from Asia were introduced into the Pacific region and co-circulated in some localities. Envelope protein gene sequences of DENV-1 from 12 patients infected on the island of New Caledonia were obtained, five of which carried genotype I viruses and six, genotype II viruses. One patient harboured a mixed infection, containing viruses assigned to both genotypes I and II, as well as a number of inter-genotypic recombinants. This is the first report of a population of dengue viruses isolated from a patient containing both parental and recombinant viruses.

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Chungue, E., O. Cassar, M. T. Drouet, M. G. Guzman, M. Laille, L. Rosen, and V. Deubel. "Molecular epidemiology of dengue-1 and dengue-4 viruses." Journal of General Virology 76, no. 7 (July 1, 1995): 1877–84. http://dx.doi.org/10.1099/0022-1317-76-7-1877.

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Nogueira, Rita Maria Ribeiro, Josélio Maria Galvão de Araújo, and Hermann Gonçalves Schatzmayr. "Dengue viruses in Brazil, 1986-2006." Revista Panamericana de Salud Pública 22, no. 5 (November 2007): 358–63. http://dx.doi.org/10.1590/s1020-49892007001000009.

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Castro, José Adail Fonseca de, Hélida Monteiro de Andrade, Semiramis Jamil Hadad do Monte, Adalberto Socorro da Silva, Karlla Celma Batista Lima Gomes, Leila Fernandes de Brito e. Amaral, Flávio de Oliveira Cipriano, et al. "Dengue viruses activity in Piauí, Brazil." Memórias do Instituto Oswaldo Cruz 98, no. 8 (December 2003): 1021–23. http://dx.doi.org/10.1590/s0074-02762003000800007.

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Rohani, Pejman, and John M. Drake. "Untangling the evolution of dengue viruses." Science 374, no. 6570 (November 19, 2021): 941–42. http://dx.doi.org/10.1126/science.abm6812.

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Nicoletti, Loredana, Massimo Ciccozzi, Antonella Marchi, Cristiano Fioretini, Patrizia Martucci, Fortunato D’Ancona, Marta Ciofi degli Atti, Maria Grazia Pompa, Giovanni Rezza, and Maria Grazia Ciufolini. "Chikungunya and Dengue Viruses in Travelers." Emerging Infectious Diseases 14, no. 1 (January 2008): 177–78. http://dx.doi.org/10.3201/eid1401.070618.

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Chan, Miranda, and Michael A. Johansson. "The Incubation Periods of Dengue Viruses." PLoS ONE 7, no. 11 (November 30, 2012): e50972. http://dx.doi.org/10.1371/journal.pone.0050972.

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Lewis, Joyce A., Gwong-Jen Chang, Robert S. Lanciotti, Richard M. Kinney, Leonard W. Mayer, and Dennis W. Trent. "Phylogenetic Relationships of Dengue-2 Viruses." Virology 197, no. 1 (November 1993): 216–24. http://dx.doi.org/10.1006/viro.1993.1582.

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Cologna, Raymond, Philip M. Armstrong, and Rebeca Rico-Hesse. "Selection for Virulent Dengue Viruses Occurs in Humans and Mosquitoes." Journal of Virology 79, no. 2 (January 15, 2005): 853–59. http://dx.doi.org/10.1128/jvi.79.2.853-859.2005.

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ABSTRACT Dengue is the most common mosquito-borne viral disease in humans. The spread of both mosquito vectors and viruses has led to the resurgence of epidemic dengue fever (a self-limited flu-like syndrome) and the emergence of dengue hemorrhagic fever (severe dengue with bleeding abnormalities) in urban centers of the tropics. There are no animal or laboratory models of dengue disease; indirect evidence suggests that dengue viruses differ in virulence, including their pathogenicities for humans and epidemic potential. We developed two assay systems (using human dendritic cells and Aedes aegypti mosquitoes) for measuring differences in virus replication that correlate with the potential to cause hemorrhagic dengue and increased virus transmission. Infection and growth experiments showed that dengue serotype 2 viruses causing dengue hemorrhagic fever epidemics (Southeast Asian genotype) can outcompete viruses that cause dengue fever only (American genotype). This fact implies that Southeast Asian genotype viruses will continue to displace other viruses, causing more hemorrhagic dengue epidemics.

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Chambers, Thomas J., Yan Liang, Deborah A. Droll, Jacob J. Schlesinger, Andrew D. Davidson, Peter J. Wright, and Xiaoshan Jiang. "Yellow Fever Virus/Dengue-2 Virus and Yellow Fever Virus/Dengue-4 Virus Chimeras: Biological Characterization, Immunogenicity, and Protection against Dengue Encephalitis in the Mouse Model." Journal of Virology 77, no. 6 (March 15, 2003): 3655–68. http://dx.doi.org/10.1128/jvi.77.6.3655-3668.2003.

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ABSTRACT Two yellow fever virus (YFV)/dengue virus chimeras which encode the prM and E proteins of either dengue virus serotype 2 (dengue-2 virus) or dengue-4 virus within the genome of the YFV 17D strain (YF5.2iv infectious clone) were constructed and characterized for their properties in cell culture and as experimental vaccines in mice. The prM and E proteins appeared to be properly processed and glycosylated, and in plaque reduction neutralization tests and other assays of antigenic specificity, the E proteins exhibited profiles which resembled those of the homologous dengue virus serotypes. Both chimeric viruses replicated in cell lines of vertebrate and mosquito origin to levels comparable to those of homologous dengue viruses but less efficiently than the YF5.2iv parent. YFV/dengue-4 virus, but not YFV/dengue-2 virus, was neurovirulent for 3-week-old mice by intracerebral inoculation; however, both viruses were attenuated when administered by the intraperitoneal route in mice of that age. Single-dose inoculation of either chimeric virus at a dose of 105 PFU by the intraperitoneal route induced detectable levels of neutralizing antibodies against the homologous dengue virus strains. Mice which had been immunized in this manner were fully protected from challenge with homologous neurovirulent dengue viruses by intracerebral inoculation compared to unimmunized mice. Protection was associated with significant increases in geometric mean titers of neutralizing antibody compared to those for unimmunized mice. These data indicate that YFV/dengue virus chimeras elicit antibodies which represent protective memory responses in the mouse model of dengue encephalitis. The levels of neurovirulence and immunogenicity of the chimeric viruses in mice correlate with the degree of adaptation of the dengue virus strain to mice. This study supports ongoing investigations concerning the use of this technology for development of a live attenuated viral vaccine against dengue viruses.

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Muturi, Ephantus J., Eva Buckner, and Jeffrey Bara. "Superinfection interference between dengue-2 and dengue-4 viruses inAedes aegyptimosquitoes." Tropical Medicine & International Health 22, no. 4 (February 24, 2017): 399–406. http://dx.doi.org/10.1111/tmi.12846.

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18

Huang, Claire Y. H., Siritorn Butrapet, Dennis J. Pierro, Gwong-Jen J. Chang, Ann R. Hunt, Natth Bhamarapravati, Duane J. Gubler, and Richard M. Kinney. "Chimeric Dengue Type 2 (Vaccine Strain PDK-53)/Dengue Type 1 Virus as a Potential Candidate Dengue Type 1 Virus Vaccine." Journal of Virology 74, no. 7 (April 1, 2000): 3020–28. http://dx.doi.org/10.1128/jvi.74.7.3020-3028.2000.

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ABSTRACT We constructed chimeric dengue type 2/type 1 (DEN-2/DEN-1) viruses containing the nonstructural genes of DEN-2 16681 virus or its vaccine derivative, strain PDK-53, and the structural genes (encoding capsid protein, premembrane protein, and envelope glycoprotein) of DEN-1 16007 virus or its vaccine derivative, strain PDK-13. We previously reported that attenuation markers of DEN-2 PDK-53 virus were encoded by genetic loci located outside the structural gene region of the PDK-53 virus genome. Chimeric viruses containing the nonstructural genes of DEN-2 PDK-53 virus and the structural genes of the parental DEN-1 16007 virus retained the attenuation markers of small plaque size and temperature sensitivity in LLC-MK2 cells, less efficient replication in C6/36 cells, and attenuation for mice. These chimeric viruses elicited higher mouse neutralizing antibody titers against DEN-1 virus than did the candidate DEN-1 PDK-13 vaccine virus or chimeric DEN-2/DEN-1 viruses containing the structural genes of the PDK-13 virus. Mutations in the envelope protein of DEN-1 PDK-13 virus affected in vitro phenotype and immunogenicity in mice. The current PDK-13 vaccine is the least efficient of the four Mahidol candidate DEN virus vaccines in human trials. The chimeric DEN-2/DEN-1 virus might be a potential DEN-1 virus vaccine candidate. This study indicated that the infectious clones derived from the candidate DEN-2 PDK-53 vaccine are promising attenuated vectors for development of chimeric flavivirus vaccines.

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19

Nogueira, Rita Maria Ribeiro, Marize Pereira Miagostovich, and Hermann Gonçalves Schatzmayr. "Molecular epidemiology of dengue viruses in Brazil." Cadernos de Saúde Pública 16, no. 1 (January 2000): 205–11. http://dx.doi.org/10.1590/s0102-311x2000000100021.

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Dengue viruses (DEN) are found as four antigenically distinct serotypes designated DEN-1, 2, 3, and 4. Laboratory evidence that strain-intratypical variation occurs among DEN viruses has been demonstrated since the 1970s, although only with the advances in molecular technologies has it been possible to determine the genetic variability of each serotype. Genotypical identification has proven to be a useful tool for determining the origin and spread of epidemics and to correlate virulence of strains. In this report we present the results of molecular epidemiological studies with the DEN-1 and DEN-2 viruses that caused dengue epidemics in Brazil during the last decade.

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20

Basu, Atanu, and Umesh C. Chaturvedi. "Vascular endothelium: the battlefield of dengue viruses." FEMS Immunology & Medical Microbiology 53, no. 3 (August 2008): 287–99. http://dx.doi.org/10.1111/j.1574-695x.2008.00420.x.

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21

Putnak, J. Robert, Niranjan Kanesa-Thasan, and Bruce L. Innis. "A putative cellular receptor for dengue viruses." Nature Medicine 3, no. 8 (August 1997): 828–29. http://dx.doi.org/10.1038/nm0897-828.

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22

Reyes-Sandoval, Arturo. "Tackling the dengue, Zika and Chikungunya viruses." Impact 2018, no. 7 (October 15, 2018): 31–33. http://dx.doi.org/10.21820/23987073.2018.7.31.

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23

Blok, J., A. J. Gibbs, S. M. McWilliam, and U. T. Vitarana. "NS 1 gene sequences from eight dengue-2 viruses and their evolutionary relationships with other dengue-2 viruses." Archives of Virology 118, no. 3-4 (September 1991): 209–23. http://dx.doi.org/10.1007/bf01314031.

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24

Huang, Claire Y. H., Siritorn Butrapet, Kiyotaka R. Tsuchiya, Natth Bhamarapravati, Duane J. Gubler, and Richard M. Kinney. "Dengue 2 PDK-53 Virus as a Chimeric Carrier for Tetravalent Dengue Vaccine Development." Journal of Virology 77, no. 21 (November 1, 2003): 11436–47. http://dx.doi.org/10.1128/jvi.77.21.11436-11447.2003.

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ABSTRACT Attenuation markers of the candidate dengue 2 (D2) PDK-53 vaccine virus are encoded by mutations that reside outside of the structural gene region of the genome. We engineered nine dengue virus chimeras containing the premembrane (prM) and envelope (E) genes of wild-type D1 16007, D3 16562, or D4 1036 virus within the genetic backgrounds of wild-type D2 16681 virus and the two genetic variants (PDK53-E and PDK53-V) of the D2 PDK-53 vaccine virus. Expression of the heterologous prM-E genes in the genetic backgrounds of the two D2 PDK-53 variants, but not that of wild-type D2 16681 virus, resulted in chimeric viruses that retained PDK-53 characteristic phenotypic markers of attenuation, including small plaque size and temperature sensitivity in LLC-MK2 cells, limited replication in C6/36 cells, and lack of neurovirulence in newborn ICR mice. Chimeric D2/1, D2/3, and D2/4 viruses replicated efficiently in Vero cells and were immunogenic in AG129 mice. Chimeric D2/1 viruses protected adult AG129 mice against lethal D1 virus challenge. Two tetravalent virus formulations, comprised of either PDK53-E- or PDK53-V-vectored viruses, elicited neutralizing antibody titers in mice against all four dengue serotypes. These antibody titers were similar to the titers elicited by monovalent immunizations, suggesting that viral interference did not occur in recipients of the tetravalent formulations. The results of this study demonstrate that the unique attenuation loci of D2 PDK-53 virus make it an attractive vector for the development of live attenuated flavivirus vaccines.

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Saluzzo, J. F., M. Cornet, P. Castagnet, C. Rey, and J. P. Digoutte. "Isolation of dengue 2 and dengue 4 viruses from patients in Senegal." Transactions of the Royal Society of Tropical Medicine and Hygiene 80, no. 1 (January 1986): 5. http://dx.doi.org/10.1016/0035-9203(86)90182-3.

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Megawati, Dewi, Sri Masyeni, Benediktus Yohan, Asri Lestarini, Rahma F. Hayati, Febrina Meutiawati, Ketut Suryana, et al. "Dengue in Bali: Clinical characteristics and genetic diversity of circulating dengue viruses." PLOS Neglected Tropical Diseases 11, no. 5 (May 22, 2017): e0005483. http://dx.doi.org/10.1371/journal.pntd.0005483.

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Cecílio, AB, ES Campanelli, KPR Souza, LB Figueiredo, and MC Resende. "Natural vertical transmission by Stegomyia albopicta as dengue vector in Brazil." Brazilian Journal of Biology 69, no. 1 (February 2009): 123–27. http://dx.doi.org/10.1590/s1519-69842009000100015.

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The mosquito Stegomyia albopicta is among the most important arbovirus vectors in the world, particularly for Dengue viruses. Their natural history suggests that biologically these viruses are highly adapted to their mosquito hosts and they were most likely mosquito viruses prior to becoming adapted to lower primates and humans. As well as being maintained by transmission among susceptible humans, Dengue viruses may also be maintained by vertical transmission in mosquitoes during inter-epidemic periods. The larvae and mosquitoes of Stegomyia albopicta were used to identify the vertical transmission of the dengue virus in nature and to confirm the vectorial capacity concerning the Dengue virus type 2 infection. The minimum infection rate concerning S. albopicta infection with the Dengue virus was 1:36.45. In Brazil this was the first time that high minimum infection rates of vertical transmission of S. albopicta were detected in this species.

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Katzelnick, Leah C., Ana Coello Escoto, Angkana T. Huang, Bernardo Garcia-Carreras, Nayeem Chowdhury, Irina Maljkovic Berry, Chris Chavez, et al. "Antigenic evolution of dengue viruses over 20 years." Science 374, no. 6570 (November 19, 2021): 999–1004. http://dx.doi.org/10.1126/science.abk0058.

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Variations in disease enhancement Secondary Dengue virus (DENV) infections can be dangerous if levels of antibodies from prior infection are inadequate to clear the virus. This RNA flavivirus exploits the presence of lower levels of heterotypic antibodies to infect immunoglobulin Fcγ receptor–bearing cells. Many RNA viruses also exhibit antigenic variation, which classically allows evasion of immune responses. Katzelnick et al . investigated whether antigenic variation in DENV has a biological function in a virus that courts immune responses to enhance replication (see the Perspective by Rohani and Drake). Using antigenic cartography on a panel of more than 400 DENV1-4 subtype samples isolated in Bangkok, Thailand, the authors found that antigenic variation in virus populations oscillated between similarity and dissimilarity across subtypes over time, with outbreaks correlating with periods of antigenic dissimilarity within serotypes. This pattern may be at least in part a result of the conflicting evolutionary pressures of immune evasion and immune enhancement. —CA

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29

Leon, Rosen. "Sexual Transmission of Dengue Viruses by Aedes Albopictus." American Journal of Tropical Medicine and Hygiene 37, no. 2 (September 1, 1987): 398–402. http://dx.doi.org/10.4269/ajtmh.1987.37.398.

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30

Freier, Jerome E., and Leon Rosen. "Vertical Transmission of Dengue Viruses by Aedes Mediovittatus." American Journal of Tropical Medicine and Hygiene 39, no. 2 (August 1, 1988): 218–22. http://dx.doi.org/10.4269/ajtmh.1988.39.218.

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31

Choudhury, Md Abu, William B. Lott, and John Aaskov. "Distribution of Fitness in Populations of Dengue Viruses." PLoS ONE 9, no. 9 (September 15, 2014): e107264. http://dx.doi.org/10.1371/journal.pone.0107264.

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32

Vasilakis, Nikos, Robert B. Tesh, Anna P. Durbin, Jorge L. Munoz-Jordan, Amelia P. A. Travassos da Rosa, and Scott C. Weaver. "Antigenic Relationships between Sylvatic and Endemic Dengue Viruses." American Journal of Tropical Medicine and Hygiene 79, no. 1 (July 1, 2008): 128–32. http://dx.doi.org/10.4269/ajtmh.2008.79.128.

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33

Vasilakis, Nikos, Edward C. Holmes, Eric B. Fokam, Ousmane Faye, Mawlouth Diallo, Amadou A. Sall, and Scott C. Weaver. "Evolutionary Processes among Sylvatic Dengue Type 2 Viruses." Journal of Virology 81, no. 17 (June 6, 2007): 9591–95. http://dx.doi.org/10.1128/jvi.02776-06.

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ABSTRACT Sylvatic dengue viruses (DENV) are transmitted in an enzootic cycle between nonhuman primates and arboreal Aedes mosquitoes in Southeast Asia and West Africa. Although previous analyses have revealed the evolutionary processes among endemic (human) DENV, little is known about viral evolution in the sylvatic cycle. Through an analysis of 14 complete coding regions of sylvatic Dengue type 2 virus sampled over a 33-year period, we show that both the rate of evolutionary change and the pattern of natural selection are similar among endemic and sylvatic DENV, although the latter have a uniquely high frequency of positive selection in the NS4B protein gene. Our findings support a recent cross-species transmission event and suggest the possibility of future DENV reemergence from the sylvatic cycle.

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Lanciotti, R. S., J. G. Lewis, D. J. Gubler, and D. W. Trent. "Molecular evolution and epidemiology of dengue-3 viruses." Journal of General Virology 75, no. 1 (January 1, 1994): 65–75. http://dx.doi.org/10.1099/0022-1317-75-1-65.

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Lanciotti, R. S., D. W. Trent, and D. J. Gubler. "Molecular evolution and phylogeny of dengue-4 viruses." Journal of General Virology 78, no. 9 (September 1, 1997): 2279–84. http://dx.doi.org/10.1099/0022-1317-78-9-2279.

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WEI, Y., S. WANG, and X. WANG. "Vectors expressing chimeric Japanese encephalitis dengue 2 viruses." Acta virologica 58, no. 04 (2014): 340–47. http://dx.doi.org/10.4149/av_2014_04_340.

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37

Harrison, Stephen C. "Immunogenic cross-talk between dengue and Zika viruses." Nature Immunology 17, no. 9 (August 19, 2016): 1010–12. http://dx.doi.org/10.1038/ni.3539.

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Vorndam, V., R. M. R. Nogueira, and D. W. Trent. "Restriction enzyme analysis of American region dengue viruses." Archives of Virology 136, no. 1-2 (March 1994): 191–96. http://dx.doi.org/10.1007/bf01538828.

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Nusa, Roy, Heni Prasetyowati, Febrina Meutiawati, Benediktus Yohan, Hidayat Trimarsanto, Tri Yuli Setianingsih, and R. Tedjo Sasmono. "Molecular surveillance of Dengue in Sukabumi, West Java province, Indonesia." Journal of Infection in Developing Countries 8, no. 06 (June 11, 2014): 733–41. http://dx.doi.org/10.3855/jidc.3959.

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Introduction: Dengue is endemic and affects people in all Indonesian provinces. Increasing dengue cases have been observed every year in Sukabumi in West Java province. Despite the endemicity, limited data is available on the genetic of dengue viruses (DENV) circulating in the country. To understand the dynamics of dengue disease, we performed molecular and serological surveillance of dengue in Sukabumi. Methodology: A total of 113 patients were recruited for this study. Serological data were obtained using anti-dengue IgM and IgG tests plus dengue NS1 antigen detection. Dengue detection and serotyping were performed using real-time RT-PCR. Viruses were isolated and the envelope genes were sequenced. Phylogenetic and evolutionary analyses were performed to determine the genotype of the viruses and their evolutionary rates. Results: Real-time RT-PCR detected DENV in 25 (22%) of 113 samples. Serotyping revealed the predominance of DENV-2 (16 isolates, 64%), followed by DENV-1 (5 isolates, 20%), and DENV-4 (4 isolates, 16%). No DENV-3 was detected in the samples. Co-circulation of genotype I and IV of DENV-1 was observed. The DENV-2 isolates all belonged to the Cosmopolitan genotype, while DENV-4 isolates were grouped into genotype II. Overall, their evolutionary rates were similar to DENV from other countries. Conclusions: We revealed the distribution of DENV serotypes and genotypes in Sukabumi. Compared to data obtained from other cities in Indonesia, we observed the differing predominance of DENV serotypes but similar genotype distribution, where the infecting viruses were closely related with Indonesian endemic viruses isolated previously.

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Mantel, N., Y. Girerd, C. Geny, I. Bernard, J. Pontvianne, J. Lang, and V. Barban. "Genetic stability of a dengue vaccine based on chimeric yellow fever/dengue viruses." Vaccine 29, no. 38 (September 2011): 6629–35. http://dx.doi.org/10.1016/j.vaccine.2011.06.101.

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Sharma, Shashi, Paban Kumar Dash, Surekha Agarwal, Jyoti Shukla, M. M. Parida, and P. V. L. Rao. "Comparative complete genome analysis of dengue virus type 3 circulating in India between 2003 and 2008." Journal of General Virology 92, no. 7 (July 1, 2011): 1595–600. http://dx.doi.org/10.1099/vir.0.030437-0.

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Dengue is endemic in most parts of the tropics including India. So far, complete genome information for Indian dengue isolates is not available. In the present study, we characterized the genome of three dengue type 3 viruses isolated from India. The genomes of all three viruses were found to be 10 707 bp long with an ORF encoding 3390 aa. Extensive molecular phylogenetic analysis based on comparison of the complete genome and envelope gene classified the recent Indian viruses into genotype III (lineage III), revealing a shift of lineage from lineage V. The sequence analysis revealed several non-conservative changes in major structural proteins. This study clearly indicates that the genotype III (lineage III) dengue type 3 viruses have been continuously circulating in major parts of India since 2003 and are responsible for the recent major outbreaks all over India. This is the first extensive study on complete genome analysis of dengue type 3 viruses in India.

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Gubler, Duane J. "Dengue and Dengue Hemorrhagic Fever." Clinical Microbiology Reviews 11, no. 3 (July 1, 1998): 480–96. http://dx.doi.org/10.1128/cmr.11.3.480.

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SUMMARY Dengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity (the cocirculation of multiple serotypes), and the emergence of dengue hemorrhagic fever in new geographic regions. In 1998 this mosquito-borne disease is the most important tropical infectious disease after malaria, with an estimated 100 million cases of dengue fever, 500,000 cases of dengue hemorrhagic fever, and 25,000 deaths annually. The reasons for this resurgence and emergence of dengue hemorrhagic fever in the waning years of the 20th century are complex and not fully understood, but demographic, societal, and public health infrastructure changes in the past 30 years have contributed greatly. This paper reviews the changing epidemiology of dengue and dengue hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both dengue fever and dengue hemorrhagic fever, serologic and virologic laboratory diagnoses, pathogenesis, surveillance, prevention, and control. A major challenge for public health officials in all tropical areas of the world is to devleop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever.

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BAIG, SHAHBAZ, ABDUL SATTAR, and SHAHBAZ AHMAD. "DENGUE FEVER;." Professional Medical Journal 19, no. 05 (October 8, 2012): 688–94. http://dx.doi.org/10.29309/tpmj/2012.19.05.2398.

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Dengue infection is one of the most common mosquito borne viral diseases of public health significance. It has been identifiedas a clinical entity since 1780. Dengue is caused by viruses that are small enveloped viruses and are members of the family Flaviviridae genusFlavivirus. It is a vector borne disease and is a global health threat. In Pakistan first epidemic was reported in 1994 and since then cases arereported every years. This year dengue infection raised the number of patients and increased the deaths. Objectives: To assess theknowledge, attitude and practices of the people regarding Dengue fever. Study Design: Cross Sectional Study. Setting: Aziz Bhatti Town,Lahore. Duration of Study: One Month. Material and methods: Convenient sampling. The investigator himself collected the information fromthe sample under study. First of all, an informed consent was obtained from the respondent under study and secrecy of the information wasensured. Data was entered and cleaned using Epi Data version 3. Data was analyzed using Epi info version 3.5.1. Results: Out of 41respondent families only 2.4% did not hear about dengue fever while 97.6% respondents were well aware of the dengue fever. 80.5% wereaware of high grade fever in dengue fever, 73.2% were aware of associated body aches. 92.7% were aware that dengue fever is preventable.95.1% were using mats, coils & repellents while 2.4% were using smoke of wet wood.36.6% were covering the water containers. 75.6% werekeeping environment dry and clean.68.3% were having opinion that they will consult GP in case of illness.85.4% told that TV/Radio were thesource of above mentioned knowledge while 9.8% doctor and 4.9% got information through newspapers. only 4.9% respondents were havingopinion that government had sprayed for dengue fever.7.3% families experienced the patient of dengue fever in their family. Conclusions: Inthis study the results are the almost same with little variations as found in other studies. The knowledge, attitude and practice are the almostsame in every studies with little variation. Majority of the families were well aware of dengue fever.

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Raut, Rajendra, and Aravinda M. de Silva. "Structural differences between dengue viruses circulating in humans and viruses used for vaccine research." Future Virology 14, no. 6 (June 2019): 379–81. http://dx.doi.org/10.2217/fvl-2019-0048.

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Kobayashi, N., K. Oda, Z. Saat, M. Sinniah, A. Igarashi, R. Thayan, B. Vijayamalar, and C. Sugimoto. "Type-3 dengue viruses responsible for the dengue epidemic in Malaysia during 1993-1994." American Journal of Tropical Medicine and Hygiene 60, no. 6 (June 1, 1999): 904–9. http://dx.doi.org/10.4269/ajtmh.1999.60.904.

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Feldstein, Leora R., John S. Brownstein, Oliver J. Brady, Simon I. Hay, and Michael A. Johansson. "Dengue on islands: a Bayesian approach to understanding the global ecology of dengue viruses." Transactions of The Royal Society of Tropical Medicine and Hygiene 109, no. 5 (March 13, 2015): 303–12. http://dx.doi.org/10.1093/trstmh/trv012.

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Hanley, Kathryn A., Laura B. Goddard, Lara E. Gilmore, Thomas W. Scott, James Speicher, Brian R. Murphy, and Alexander G. Pletnev. "Infectivity of West Nile/Dengue Chimeric Viruses for West Nile and Dengue Mosquito Vectors." Vector-Borne and Zoonotic Diseases 5, no. 1 (March 2005): 1–10. http://dx.doi.org/10.1089/vbz.2005.5.1.

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Bhavya, M., M. Ramya, N. Nagarjun, Nagarathna Amresh, and Balasubramanian Sathyamurthy. "Docking study of Selected Vinis vitifera seeds constituents on Dengue viral proteins – An In Silico approach." Indian Journal of Pharmaceutical and Biological Research 6, no. 04 (December 31, 2018): 25–31. http://dx.doi.org/10.30750/ijpbr.6.4.5.

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Dengue is a mosquito-borne systemic viral infection caused by any of the four antigenically related dengue viruses (DENV).The dengue virus belongs to the Flaviviridae family of viruses that cause diseases in humans.A virtual screening analysis of phytochemical structures with dengue virus protein targets has been carried out using a molecular docking approach with vins vinifera seeds. Grapes (Vinis vitifera) are believed to have health benefits due to their antioxidant activity and polyphenols. In this study we examined the binding affinities of 14 ligands with seven non structural Dengu viral proteins through In Silico methods like virtual screening and docking process which showed that compound F and compound N had high binding efficiencies with these proteins along with the type of hydrogen bonds and their respective amino acid residues at their docked sites.

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Raviprakash, Kanakatte, Danher Wang, Dan Ewing, David H. Holman, Karla Block, Jan Woraratanadharm, Lan Chen, Curtis Hayes, John Y. Dong, and Kevin Porter. "A Tetravalent Dengue Vaccine Based on a Complex Adenovirus Vector Provides Significant Protection in Rhesus Monkeys against All Four Serotypes of Dengue Virus." Journal of Virology 82, no. 14 (May 14, 2008): 6927–34. http://dx.doi.org/10.1128/jvi.02724-07.

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ABSTRACT Nearly a third of the human population is at risk of infection with the four serotypes of dengue viruses, and it is estimated that more than 100 million infections occur each year. A licensed vaccine for dengue viruses has become a global health priority. A major challenge to developing a dengue vaccine is the necessity to produce fairly uniform protective immune responses to all four dengue virus serotypes. We have developed two bivalent dengue virus vaccines, using a complex adenovirus vector, by incorporating the genes expressing premembrane (prM) and envelope (E) proteins of dengue virus types 1 and 2 (dengue-1 and -2, respectively) (CAdVax-Den12) or dengue-3 and -4 (CAdVax-Den34). Rhesus macaques were vaccinated by intramuscular inoculation of a tetravalent dengue vaccine formulated by combining the two bivalent vaccine constructs. Vaccinated animals produced high-titer antibodies that neutralized all four serotypes of dengue viruses in vitro. The ability of the vaccine to induce rapid, as well as sustained, protective immune responses was examined with two separate live-virus challenges administered at 4 and 24 weeks after the final vaccination. For both of these virus challenge studies, significant protection from viremia was demonstrated for all four dengue virus serotypes in vaccinated animals. Viremia from dengue-1 and dengue-3 challenges was completely blocked, whereas viremia from dengue-2 and dengue-4 was significantly reduced, as well as delayed, compared to that of control-vaccinated animals. These results demonstrate that the tetravalent dengue vaccine formulation provides significant protection in rhesus macaques against challenge with all four dengue virus serotypes.

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Tripathy, Mr Chandra Sekhar, Dr Anil Kumar, Dr Santosh Kumar Behera, Muhammad Akram, Dr Asadollah Asadi, Dr Arash Abdolmaleki, Mr Amir Mohammad Ostovar Abarghoee, et al. "DengueVrsEllagic Acid & Ferric Carboxymaltose: InSilico." Saudi Journal of Biomedical Research 7, no. 7 (July 16, 2022): 211–18. http://dx.doi.org/10.36348/sjbr.2022.v07i07.001.

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Backgrounds: Dengue viruses are transmitted to humans via mosquito bites from infected Aedes species (Aedesaegypti or Aedesalbopictus). Dengue fever affects over half of the world's population, or about 4 billion people. Dengue fever is a common cause of sickness in high-risk settings. Methods: In the current study two serotypes of Dengue viruses namely DENV1 and DENV2 taken for the study. Here two important compounds namely Ellagic acid and Ferric Carboxymaltose chosen for the targets to be inhibited. In silico docking approach performed to dock the two compounds against the DENV1 and DENV2 viruses of Dengue. Autodock 4.2 tool chosen for the docking purpose. Results: Dengue i.e., DENV-1 & 2 indicate excellent biding property with Ellagic Acid & Ferric Carboxymaltose of the order -6.02 kcal/mol& -6.9 kcal/mol, respectively. Either are hematinic; pregnancy safe; non-toxic; complete synergy between either vis-à-vis virus targets\binding sites; with supportive therapies; etc. Novel. It was found that, the Ellagic acid is more effective for DENV1 virus and Ferric kcal/mol, respectively. Conclusions: It can be stated that, these two drugs can be better approach for future study against the Dengue viruses and expected drug candidates.

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Journal articles on the topic 'Dengue viruses'

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