Academic literature on the topic 'Denisovaner'

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Journal articles on the topic "Denisovaner"

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Bennett, E. Andrew, Isabelle Crevecoeur, Bence Viola, Anatoly P. Derevianko, Michael V. Shunkov, Thierry Grange, Bruno Maureille, and Eva-Maria Geigl. "Morphology of the Denisovan phalanx closer to modern humans than to Neanderthals." Science Advances 5, no. 9 (September 2019): eaaw3950. http://dx.doi.org/10.1126/sciadv.aaw3950.

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A fully sequenced high-quality genome has revealed in 2010 the existence of a human population in Asia, the Denisovans, related to and contemporaneous with Neanderthals. Only five skeletal remains are known from Denisovans, mostly molars; the proximal fragment of a fifth finger phalanx used to generate the genome, however, was too incomplete to yield useful morphological information. Here, we demonstrate through ancient DNA analysis that a distal fragment of a fifth finger phalanx from the Denisova Cave is the larger, missing part of this phalanx. Our morphometric analysis shows that its dimensions and shape are within the variability of Homo sapiens and distinct from the Neanderthal fifth finger phalanges. Thus, unlike Denisovan molars, which display archaic characteristics not found in modern humans, the only morphologically informative Denisovan postcranial bone identified to date is suggested here to be plesiomorphic and shared between Denisovans and modern humans.
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Akkuratov, Evgeny E., Mikhail S. Gelfand, and Ekaterina E. Khrameeva. "Neanderthal and Denisovan ancestry in Papuans: A functional study." Journal of Bioinformatics and Computational Biology 16, no. 02 (April 2018): 1840011. http://dx.doi.org/10.1142/s0219720018400115.

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Sequencing of complete nuclear genomes of Neanderthal and Denisovan stimulated studies about their relationship with modern humans demonstrating, in particular, that DNA alleles from both Neanderthal and Denisovan genomes are present in genomes of modern humans. The Papuan genome is a unique object because it contains both Neanderthal and Denisovan alleles. Here, we have shown that the Papuan genomes contain different gene functional groups inherited from each of the ancient people. The Papuan genomes demonstrate a relative prevalence of Neanderthal alleles in genes responsible for the regulation of transcription and neurogenesis. The enrichment of specific functional groups with Denisovan alleles is less pronounced; these groups are responsible for bone and tissue remodeling. This analysis shows that introgression of alleles from Neanderthals and Denisovans to Papuans occurred independently and retention of these alleles may carry specific adaptive advantages.
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Rogers, Alan R., Nathan S. Harris, and Alan A. Achenbach. "Neanderthal-Denisovan ancestors interbred with a distantly related hominin." Science Advances 6, no. 8 (February 2020): eaay5483. http://dx.doi.org/10.1126/sciadv.aay5483.

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Previous research has shown that modern Eurasians interbred with their Neanderthal and Denisovan predecessors. We show here that hundreds of thousands of years earlier, the ancestors of Neanderthals and Denisovans interbred with their own Eurasian predecessors—members of a “superarchaic” population that separated from other humans about 2 million years ago. The superarchaic population was large, with an effective size between 20 and 50 thousand individuals. We confirm previous findings that (i) Denisovans also interbred with superarchaics, (ii) Neanderthals and Denisovans separated early in the middle Pleistocene, (iii) their ancestors endured a bottleneck of population size, and (iv) the Neanderthal population was large at first but then declined in size. We provide qualified support for the view that (v) Neanderthals interbred with the ancestors of modern humans.
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Zhang, Dongju, Huan Xia, Fahu Chen, Bo Li, Viviane Slon, Ting Cheng, Ruowei Yang, et al. "Denisovan DNA in Late Pleistocene sediments from Baishiya Karst Cave on the Tibetan Plateau." Science 370, no. 6516 (October 29, 2020): 584–87. http://dx.doi.org/10.1126/science.abb6320.

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A late Middle Pleistocene mandible from Baishiya Karst Cave (BKC) on the Tibetan Plateau has been inferred to be from a Denisovan, an Asian hominin related to Neanderthals, on the basis of an amino acid substitution in its collagen. Here we describe the stratigraphy, chronology, and mitochondrial DNA extracted from the sediments in BKC. We recover Denisovan mitochondrial DNA from sediments deposited ~100 thousand and ~60 thousand years ago (ka) and possibly as recently as ~45 ka. The long-term occupation of BKC by Denisovans suggests that they may have adapted to life at high altitudes and may have contributed such adaptations to modern humans on the Tibetan Plateau.
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Schwartz, K., and M. Sorokin. "The human genome reveals the evolution of Homo sapiens." BULLETIN of the L.N. Gumilyov Eurasian National University. BIOSCIENCE Series 134, no. 1 (2021): 38–45. http://dx.doi.org/10.32523/2616-7034-2021-134-1-38-45.

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The evolution of modern humans began two and a half million years ago as Homo erectus. Several hundred thousand years ago, Neanderthals, Denisovans, and modern men Homo sapiens have been separated from the Homo erectus branch. Nevertheless, Homo sapiens is the only one that has survived to our days. The complex history of Homo is revealed by genetic research and comparison of the modern human genome with genes of Neanderthals and Denisovans. Svante Pääbo, a professor at the Max Planck Institute for Evolutionary Anthropology, made a significant contribution to these studies and decoded the genome of Neanderthals and Denisovans. Comparison of the genome of modern humans with the genes of Neanderthals and Denisovans made it possible to reveal the size of the population, the paths and times of migrations, interactions of various groups of ancient humans and their biological crossing. It was found that in Eurasia, modern man carries traces of Neanderthal genes, whereas in Asia and Oceania – Denisovan genes. According to anthropological research, the survival of Homo sapiens was driven by the cognitive revolution, which took place about seventy thousand years ago and included the development of language, communication and association in large groups.
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Zhang, Xinjun, Kelsey E. Witt, Mayra M. Bañuelos, Amy Ko, Kai Yuan, Shuhua Xu, Rasmus Nielsen, and Emilia Huerta-Sanchez. "The history and evolution of the Denisovan-EPAS1 haplotype in Tibetans." Proceedings of the National Academy of Sciences 118, no. 22 (May 28, 2021): e2020803118. http://dx.doi.org/10.1073/pnas.2020803118.

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Recent studies suggest that admixture with archaic hominins played an important role in facilitating biological adaptations to new environments. For example, interbreeding with Denisovans facilitated the adaptation to high-altitude environments on the Tibetan Plateau. Specifically, the EPAS1 gene, a transcription factor that regulates the response to hypoxia, exhibits strong signatures of both positive selection and introgression from Denisovans in Tibetan individuals. Interestingly, despite being geographically closer to the Denisova Cave, East Asian populations do not harbor as much Denisovan ancestry as populations from Melanesia. Recently, two studies have suggested two independent waves of Denisovan admixture into East Asians, one of which is shared with South Asians and Oceanians. Here, we leverage data from EPAS1 in 78 Tibetan individuals to interrogate which of these two introgression events introduced the EPAS1 beneficial sequence into the ancestral population of Tibetans, and we use the distribution of introgressed segment lengths at this locus to infer the timing of the introgression and selection event. We find that the introgression event unique to East Asians most likely introduced the beneficial haplotype into the ancestral population of Tibetans around 48,700 (16,000–59,500) y ago, and selection started around 9,000 (2,500–42,000) y ago. Our estimates suggest that one of the most convincing examples of adaptive introgression is in fact selection acting on standing archaic variation.
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Zavala, Elena I., Zenobia Jacobs, Benjamin Vernot, Michael V. Shunkov, Maxim B. Kozlikin, Anatoly P. Derevianko, Elena Essel, et al. "Pleistocene sediment DNA reveals hominin and faunal turnovers at Denisova Cave." Nature 595, no. 7867 (June 23, 2021): 399–403. http://dx.doi.org/10.1038/s41586-021-03675-0.

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AbstractDenisova Cave in southern Siberia is the type locality of the Denisovans, an archaic hominin group who were related to Neanderthals1–4. The dozen hominin remains recovered from the deposits also include Neanderthals5,6 and the child of a Neanderthal and a Denisovan7, which suggests that Denisova Cave was a contact zone between these archaic hominins. However, uncertainties persist about the order in which these groups appeared at the site, the timing and environmental context of hominin occupation, and the association of particular hominin groups with archaeological assemblages5,8–11. Here we report the analysis of DNA from 728 sediment samples that were collected in a grid-like manner from layers dating to the Pleistocene epoch. We retrieved ancient faunal and hominin mitochondrial (mt)DNA from 685 and 175 samples, respectively. The earliest evidence for hominin mtDNA is of Denisovans, and is associated with early Middle Palaeolithic stone tools that were deposited approximately 250,000 to 170,000 years ago; Neanderthal mtDNA first appears towards the end of this period. We detect a turnover in the mtDNA of Denisovans that coincides with changes in the composition of faunal mtDNA, and evidence that Denisovans and Neanderthals occupied the site repeatedly—possibly until, or after, the onset of the Initial Upper Palaeolithic at least 45,000 years ago, when modern human mtDNA is first recorded in the sediments.
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Sawyer, Susanna, Gabriel Renaud, Bence Viola, Jean-Jacques Hublin, Marie-Theres Gansauge, Michael V. Shunkov, Anatoly P. Derevianko, Kay Prüfer, Janet Kelso, and Svante Pääbo. "Nuclear and mitochondrial DNA sequences from two Denisovan individuals." Proceedings of the National Academy of Sciences 112, no. 51 (November 16, 2015): 15696–700. http://dx.doi.org/10.1073/pnas.1519905112.

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Denisovans, a sister group of Neandertals, have been described on the basis of a nuclear genome sequence from a finger phalanx (Denisova 3) found in Denisova Cave in the Altai Mountains. The only other Denisovan specimen described to date is a molar (Denisova 4) found at the same site. This tooth carries a mtDNA sequence similar to that of Denisova 3. Here we present nuclear DNA sequences from Denisova 4 and a morphological description, as well as mitochondrial and nuclear DNA sequence data, from another molar (Denisova 8) found in Denisova Cave in 2010. This new molar is similar to Denisova 4 in being very large and lacking traits typical of Neandertals and modern humans. Nuclear DNA sequences from the two molars form a clade with Denisova 3. The mtDNA of Denisova 8 is more diverged and has accumulated fewer substitutions than the mtDNAs of the other two specimens, suggesting Denisovans were present in the region over an extended period. The nuclear DNA sequence diversity among the three Denisovans is comparable to that among six Neandertals, but lower than that among present-day humans.
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Rogers, Alan R., Ryan J. Bohlender, and Chad D. Huff. "Early history of Neanderthals and Denisovans." Proceedings of the National Academy of Sciences 114, no. 37 (August 7, 2017): 9859–63. http://dx.doi.org/10.1073/pnas.1706426114.

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Extensive DNA sequence data have made it possible to reconstruct human evolutionary history in unprecedented detail. We introduce a method to study the past several hundred thousand years. Our results show that (i) the Neanderthal–Denisovan lineage declined to a small size just after separating from the modern lineage, (ii) Neanderthals and Denisovans separated soon thereafter, and (iii) the subsequent Neanderthal population was large and deeply subdivided. They also (iv) support previous estimates of gene flow from Neanderthals into modern Eurasians. These results suggest an archaic human diaspora early in the Middle Pleistocene.
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Lodewijk, Gerrald A., Diana P. Fernandes, Iraklis Vretzakis, Jeanne E. Savage, and Frank M. J. Jacobs. "Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels." Molecular Biology and Evolution 37, no. 9 (April 24, 2020): 2531–48. http://dx.doi.org/10.1093/molbev/msaa104.

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Abstract Ever since the availability of genomes from Neanderthals, Denisovans, and ancient humans, the field of evolutionary genomics has been searching for protein-coding variants that may hold clues to how our species evolved over the last ∼600,000 years. In this study, we identify such variants in the human-specific NOTCH2NL gene family, which were recently identified as possible contributors to the evolutionary expansion of the human brain. We find evidence for the existence of unique protein-coding NOTCH2NL variants in Neanderthals and Denisovans which could affect their ability to activate Notch signaling. Furthermore, in the Neanderthal and Denisovan genomes, we find unusual NOTCH2NL configurations, not found in any of the modern human genomes analyzed. Finally, genetic analysis of archaic and modern humans reveals ongoing adaptive evolution of modern human NOTCH2NL genes, identifying three structural variants acting complementary to drive our genome to produce a lower dosage of NOTCH2NL protein. Because copy-number variations of the 1q21.1 locus, encompassing NOTCH2NL genes, are associated with severe neurological disorders, this seemingly contradicting drive toward low levels of NOTCH2NL protein indicates that the optimal dosage of NOTCH2NL may have not yet been settled in the human population.
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Dissertations / Theses on the topic "Denisovaner"

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Sawyer, Susanna. "Insights into Neandertals and Denisovans from Denisova Cave." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-204682.

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Denisova Cave is located in the Altai mountains of Russia. Excavations from this cave have yielded two large hominin molars and three hominin phalanxes from the Pleistocene. One of the phalanxes (Denisova 3) had extraordinary DNA preservation allowing the sequencing of high quality nuclear and mitochondrial DNA (mtDNA) genomes and has been shown to belong to a young girl from hereto unknown sister group of Neandertals, called Denisovans. The mtDNA of Denisova 3 surprisingly split from the mtDNA ancestor of modern humans and Neandertals twice as long ago as the split of modern humans and Neandertals. The mtDNA of one of the molars (Denisova 4) was also sequenced and differs at only two positions from the mtDNA of Denisova 3. A second phalanx (Altai 1) also yielded a high quality genome, and was a Neandertal. While Neandertals show an admixture signal of 1-4% into present-day non-Africans, Denisovans show an admixture of up to 5% in present-day Oceanians, and to a much lesser extent East Asians. This thesis encompasses two studies. In the first study, we sequenced the complete mtDNA genome of the additional molar (Denisova 8), as well as a few megabases of nuclear DNA from Denisova 4 and Denisova 8. While the mtDNA of Denisova 8 is clearly of the Denisova type, its branch to the most recent common ancestor of Denisovans is half as long as the branch leading to Denisova 3 or Denisova 4, indicating that Denisova 8 lived many millenia before the other two. Both Denisova 4 and 8 fall together with Denisova 3 based on nuclear DNA, bringing the number of known Denisovans from one to three. In the second study, we sequenced an almost complete mtDNA and a few megabases of nuclear DNA from the third hominin phalanx from Denisova Cave, Altai 2. Both the mtDNA and the nuclear DNA show Altai 2 to be a Neandertal. The mtDNA also showed the presence of substantial Pleistocene spotted hyena contamination. Low levels of spotted hyena contamination were also found in Altai 1, Denisova 3 and Denisova 4. Partial mtDNA genomes of the contaminating spotted hyenas from these four hominins were compared to mtDNA genomes of other extant and extinct spotted hyenas. We show that the spotted hyenas that contaminated the two Denisovans come from a population of spotted hyenas found in Pleistocene Europe as well as present-day Africa, while the spotted hyenas that contaminated Altai 2, and possibly Altai 1, come from a population of spotted hyenas found in Pleisticene eastern Russia and northern China. This indicates that Denisova Cave was a meeting point of eastern and western hominins as well as eastern and western spotted hyena populations.
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Yatskiv, Yuriy Romanovich. "A Haplotype Analysis of an Archaic Denisovan Genome." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1481145733356233.

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Sawyer, Susanna [Verfasser], and Svante [Gutachter] Pääbo. "Insights into Neandertals and Denisovans from Denisova Cave / Susanna Sawyer ; Gutachter: Svante Pääbo." Leipzig : Universitätsbibliothek Leipzig, 2016. http://d-nb.info/1240482108/34.

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Thibault, Mary Grace. "Modeling seagoing migration of early Homo via paleoclimate drift experiments to Sulawesi, Indonesia." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555500422012595.

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Sawyer, Susanna. "Insights into Neandertals and Denisovans from Denisova Cave." Doctoral thesis, 2015. https://ul.qucosa.de/id/qucosa%3A14757.

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Denisova Cave is located in the Altai mountains of Russia. Excavations from this cave have yielded two large hominin molars and three hominin phalanxes from the Pleistocene. One of the phalanxes (Denisova 3) had extraordinary DNA preservation allowing the sequencing of high quality nuclear and mitochondrial DNA (mtDNA) genomes and has been shown to belong to a young girl from hereto unknown sister group of Neandertals, called Denisovans. The mtDNA of Denisova 3 surprisingly split from the mtDNA ancestor of modern humans and Neandertals twice as long ago as the split of modern humans and Neandertals. The mtDNA of one of the molars (Denisova 4) was also sequenced and differs at only two positions from the mtDNA of Denisova 3. A second phalanx (Altai 1) also yielded a high quality genome, and was a Neandertal. While Neandertals show an admixture signal of 1-4% into present-day non-Africans, Denisovans show an admixture of up to 5% in present-day Oceanians, and to a much lesser extent East Asians. This thesis encompasses two studies. In the first study, we sequenced the complete mtDNA genome of the additional molar (Denisova 8), as well as a few megabases of nuclear DNA from Denisova 4 and Denisova 8. While the mtDNA of Denisova 8 is clearly of the Denisova type, its branch to the most recent common ancestor of Denisovans is half as long as the branch leading to Denisova 3 or Denisova 4, indicating that Denisova 8 lived many millenia before the other two. Both Denisova 4 and 8 fall together with Denisova 3 based on nuclear DNA, bringing the number of known Denisovans from one to three. In the second study, we sequenced an almost complete mtDNA and a few megabases of nuclear DNA from the third hominin phalanx from Denisova Cave, Altai 2. Both the mtDNA and the nuclear DNA show Altai 2 to be a Neandertal. The mtDNA also showed the presence of substantial Pleistocene spotted hyena contamination. Low levels of spotted hyena contamination were also found in Altai 1, Denisova 3 and Denisova 4. Partial mtDNA genomes of the contaminating spotted hyenas from these four hominins were compared to mtDNA genomes of other extant and extinct spotted hyenas. We show that the spotted hyenas that contaminated the two Denisovans come from a population of spotted hyenas found in Pleistocene Europe as well as present-day Africa, while the spotted hyenas that contaminated Altai 2, and possibly Altai 1, come from a population of spotted hyenas found in Pleisticene eastern Russia and northern China. This indicates that Denisova Cave was a meeting point of eastern and western hominins as well as eastern and western spotted hyena populations.
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Petr, Martin. "Natural selection and demography in ancient human introgression." 2020. https://ul.qucosa.de/id/qucosa%3A74953.

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The ability to recover ancient DNA from skeletal material has completely transformed the field of evolutionary anthropology, making it possible to sequence the genomes of individuals who lived thousands of years ago. In addition to solving the long-standing question of admixture between neanderthals and modern humans and uncovering evidence of dramatic migration events throughout human history, ancient DNA has become an important resource for understanding many facets of natural selection, which is often challenging using today's genetic variation alone. Chapter 1 examines the dynamics of negative selection acting against Neanderthal ancestry in modern humans and establishes its limits over long evolutionary timescales. It shows that the previously reported monotonic decline in Neanderthal ancestry over the last fifty-thousand years, thought to be a result of negative selection, is a statistical artifact caused by incorrect assumptions about modern human demographic history, in particular the gene flow between Africa and West Eurasia. Re-estimation of the Neanderthal ancestry proportions over time using a more robust statistic no longer infers a significant decline in Neanderthal ancestry, which is proven to be consistent with simulations of negative selection across a wide range of selection parameters. Chapter 2 describes the first comprehensive analysis of the Y chromosomes of neanderthals and Denisovans. Although Neanderthals and Denisovans form a sister group to modern humans at the autosomal level, Neanderthal Y chromosomes are more similar to modern humans than Denisovan Y chromosomes. In fact, the Y chromosomes of late neanderthals represent a lineage introgressed from an early modern human population. This introgression, which occurred hundreds of thousands of years, completely replaced the Y chromosomes of early neanderthals, reflecting the observations made from mitochondrial DNA. Population genetic simulations of selection and introgression show that although a complete replacement of both mitochondrial DNA and Y chromosomes is unlikely under neutrality, higher deleterious burden of neanderthals predicts a rapid replacement of both loci by their modern human counterparts. Finally, Chapter 3 presents an R package admixer, designed to facilitate the programming of automated, fully reproducible population genetic analyses using ADMIXTOOLS, a suite of programs widely used in ancient DNA research.
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Chintalapati, Manjusha. "Indels and large scale variation in archaic hominins compared to present day humans." 2018. https://ul.qucosa.de/id/qucosa%3A32595.

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Books on the topic "Denisovaner"

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The Cygnus Key: The Denisovan Legacy, Göbekli Tepe, and the Birth of Egypt. Bear & Company, 2018.

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Ayala, Francisco J., and Camilo J. Cela-Conde. Neanderthals and modern humans. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198739906.003.0011.

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This chapter deals with the similarities and differences between Homo neanderthalensis and Homo sapiens, by considering genetic, brain, and cognitive evidence. The genetic differentiation emerges from fossil genetic evidence obtained first from mtDNA and later from nuclear DNA. With high throughput whole genome sequencing, sequences have been obtained from the Denisova Cave (Siberia) fossils. Nuclear DNA of a third species (“Denisovans”) has been obtained from the same cave and used to define the phylogenetic relationships among the three species during the Upper Palaeolithic. Archaeological comparisons make it possible to advance a four-mode model of the evolution of symbolism. Neanderthals and modern humans would share a “modern mind” as defined up to Symbolic Mode 3. Whether the Neanderthals reached symbolic Mode 4 remains unsettled.
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Book chapters on the topic "Denisovaner"

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Williams, Sloan R. "The Neanderthal and Denisovan Genomes." In A Companion to Anthropological Genetics, 69–88. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2019. http://dx.doi.org/10.1002/9781118768853.ch6.

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Herrera, Rene J., and Ralph Garcia-Bertrand. "Neanderthals, Denisovans, and Hobbits." In Ancestral DNA, Human Origins, and Migrations, 175–206. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-804124-6.00006-9.

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Coolidge, Frederick L. "A Brief History of Life and Brain Evolution." In Evolutionary Neuropsychology, 1–26. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190940942.003.0001.

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This chapter reviews some of the fundamentals of evolution, particularly adaptations and exaptations. Adaptations are physical or behavioral features that through natural selection aided survival and reproduction. Exaptations are physical or behavioral features that have been co-opted from their initial adaptive functions and subsequently enhanced fitness. The reuse, recycling, or redeployment of brain neurons for purposes other than their original adaption may be considered a central organizing principle of the brain. The chapter reviews the beginnings of life and presents a timeline of life through the evolution of hominins. The term hominin refers to all current and extinct relatives and ancestors of Homo sapiens, including the australopithecines and habilines, within about the last 6 million years. The chapter introduces the hypothesis that Homo sapiens survived and flourished, instead of Neandertals, Denisovans, and other hominins, because of brain shape differences, which created cognitive differences that enhanced the evolutionary fitness of Homo sapiens.
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