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Dissertations / Theses on the topic 'Dense collagen'

Author: Grafiati

Published: 25 May 2024

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1

Lama, Miléna. "Structure-properties relationship in dense collagen gels produced by injection of spray-dried collagen." Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS559.pdf.

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Injecter des gels denses de collagène pour obtenir des matériaux 3D, biomimétiques en termes d’architecture et de propriétés mécaniques, est un enjeu pour la régénération tissulaire car cela pourrait éviter des chirurgies lourdes. Des solutions de collagène très concentrées ont la capacité de former des mésophases dont la géométrie mime celle des tissus biologiques. Ainsi, il est possible d’obtenir des gels de collagène en 3D possédant une meilleure tenue mécanique, sans utiliser de réticulant chimique qui peut induire des inflammations. Cependant, l’injection de solutions de collagène très co

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2

Metzmacher, Iris. "Enzymatic Degradation and Drug Release Behavior of Dense Collagen Implants." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-45495.

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3

Ghezzi, Chiara Elia. "Dense collagen-based tubular tissue constructs for airway tissue engineering." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114489.

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To date, only engineered tissues of planar geometry, such as epidermal and dermal layer substitutes, have successfully reached the market, mainly due to their relative low complexity and simple geometry. In contrast, the mechanical and functional requirements of tubular tissues are more stringent compared to planar tissues. Tubular tissues, which are the main components of several biological systems (e.g. circulatory, urinary or respiratory), not only present an increased complexity in geometry and tissue architecture, they are also populated by mixed cell types. In addition, these are continu

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4

Alekseeva, T. "Introducing controllable 3D features into dense collagen constructs for tissue engineering applications." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1344165/.

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Plastic compression of collagen is based on unidirectional expulsion of fluid from hydrated collagen gel. The process results in dense collagen sheet, with higher density of collagen at the fluid leaving surface (FLS) than non-FLS. Compression process is completely cell-independent and at the same time cell-friendly. However, engineered tissues should replicate not only components of tissues in vivo (extracellular matrix and cells) but also their complex micro-architecture. Therefore the aim of this work was to develop collagen-based scaffolds with controllable micro-architecture for biomedica

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5

Alcock, Rebekah D. "Dietary collagen intake and sources for support of dense connective tissues in athletes." Thesis, Australian Catholic University, 2019. https://acuresearchbank.acu.edu.au/download/735dcbe3102bcc4d19ddd84efe04e7267e078206d002757b8221417651e13847/5376764/Alcock_2019_Dietary_collagen_intake_and_sources_for_Redacted.pdf.

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Intake of dietary sources of collagen may support the synthesis of collagen in varying tissues, with the availability of key amino acids being a likely contributor to its effectiveness. This study analyzed commonly consumed preparations of bone broth (BB) to assess the amount and consistency of its amino acid content. Commercial and laboratory prepared samples, made with standardized and variable (non-standardized) protocols were analyzed for key amino acids (glycine, lysine, proline, leucine, hydroxyproline and hydroxylysine). The main finding of the study was that amino acid concentrations i

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6

Marelli, Benedetto. "In vitro mineralization of an osteoid-like dense collagen construct for bone tissue engineering." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106503.

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Bone tissue engineering (BTE) has emerged as a promising solution to heal the millions of people worldwide that suffer from bone degenerative pathologies and bone fractures. Since bone is a biocomposite of type I collagen nanofibres (namely osteoid) reinforced with nanocrystals of carbonated hydroxylapatite (CHA), reconstituted type I collagen gels are an attractive choice as scaffolds for BTE. However, to date, the design of a collagenous bone-like construct ready to be implanted is far from being accomplished, as collagen matrices are difficult to mineralize. The aim of this doctoral researc

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7

Chicatun, Florencia. "In vitro generation of a bilayered dense collagen / chitosan hydrogel scaffold as an osteochondral model." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121353.

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Success of osteochondral tissue engineering (TE) requires stratified scaffolds that mimic the biophysicochemical composition of the cellular environment of both the cartilage and subchondral bone. In vitro reconstituted collagen type I (Coll) hydrogels are widely used as biomimetic scaffolds for TE, however due to their highly-hydrated nature they collapse due to gravitational forces (self-compression; SC). Plastic compression (PC) is a method that rapidly enables the generation of dense scaffolds with solid weight percent approaching native tissues values.The aim of this doctoral research was

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8

Serpooshan, Vahid. "Control of dense collagen gel scaffolds for tissue engineering through measurement and modeling of hydraulic permeability." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97117.

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Among various natural biopolymers, type I collagen gels have demonstrated the highest potential as biomimetic scaffolds for tissue engineering (TE). However, the successful application of collagen gels requires a greater understanding of the relationship between their microstructure and physical-mechanical properties. Therefore, a precise method to modulate collagen gel microstructure in order to attain optimal scaffold properties for diverse biomedical applications is necessary. This dissertation describes a new approach to produce collagen gels with defined microstructures, quantified by hyd

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9

Serpooshan, Vahid. "Control of dense collagen gel scaffolds for tissue engineering through measurement and modelling of hydraulic permeability." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111921.

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Among various natural biopolymers, type I collagen gels have demonstrated the highest potential as biomimetic scaffolds for tissue engineering (TE). However, the successful application of collagen gels requires a greater understanding of the relationship between their microstructure and physical-mechanical properties. Therefore, a precise method to modulate collagen gel microstructure in order to attain optimal scaffold properties for diverse biomedical applications is necessary. This dissertation describes a new approach to produce collagen gels with defined microstructures, quantified by hyd

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10

Camman, Marie. "Hydrogels de collagène dense structurés par impression 3D pour modéliser la matrice extracellulaire musculaire et cardiaque dans la Dystrophie Musculaire de Duchenne." Electronic Thesis or Diss., Sorbonne université, 2022. http://www.theses.fr/2022SORUS447.

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La myopathie de Duchenne est une maladie génétique rare caractérisée par une dégénération progressive des muscles striés notamment squelettiques et cardiaque. A l’échelle de la cellule, l’absence de dystrophine perturbe l'intégrité de la membrane plasmique, la signalisation cellulaire et par conséquent la contraction musculaire. A l’échelle du tissu, ces changements se traduisent par une faiblesse musculaire et par une perturbation de la matrice extracellulaire qui se rigidifie, perd son organisation anisotrope et devient peu poreuse. La matrice joue un rôle essentiel dans l’évolution de la ma

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11

Oliveira, Stéphanie de. "Hydrogels denses collagène/acide hyaluronique par biofabrication pour le développement d’un nouveau modèle in vitro d’Annulus Fibrosus." Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS307.

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La dégénérescence du disque intervertébral est une pathologie irréversible entraînant des maux de dos intenses. Les disques intervertébraux sont composés de trois parties : le Nucleus Pulposus (NP) situé au centre, entouré par l’Annulus Fibrosus (AF) et deux plateaux cartilagineux de part et d’autre. La dégénérescence du disque est caractérisée par une baisse d’hydratation du NP qui devient fibreux et ne joue plus son rôle d’absorbeur de chocs. Les forces exercées par le NP sur l’AF vont le rompre provoquant l’écoulement du NP ce qui génère une hernie discale. De nombreux traitements ont été d

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12

Collignon, Anne-Margaux. "Utilisation de cellules souches pulpaires combinées à une matrice de collagène pour la réparation osseuse cranio-faciale Strategies developed to induce, direct, and potentiate bone healing Accelerated craniofacial bone regeneration through dense collagen gel scaffolds seeded with dental pulp stem cells Mouse Wnt1-CRE-RosaTomato dental pulp stem cells directly contribute to the calvarial bone regeneration process Early angiogenesis detected by PET imaging with 64Cu-NODAGA-RGD is predictive of bone critical defect repair." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB113.

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La région cranio-faciale est particulièrement vulnérable aux pertes de structures. Sa localisation et sa visibilité font qu'une atteinte entraîne des troubles, aussi bien physiques (alimentation, phonation...) que psychologiques (intégrité de la personne...). Les traitements actuels (régénération osseuse guidée, autogreffe osseuse ou allogreffe) sont particulièrement invasifs et présentent un taux d'échec élevé. Tout cela affecte fortement la qualité de vie du patient. De plus, le coût direct de ces traitements est important pour les systèmes de santé et le patient. Il existe donc un réel beso

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13

Gobeaux, Frédéric. "PHASES DENSES DE COLLAGÈNE DE TYPE I :TRANSITION ISOTROPE/CHOLESTÉRIQUE, FIBRILLOGENÈSE ET MINÉRALISATION." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2007. http://tel.archives-ouvertes.fr/tel-00337402.

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L'objectif de ce travail consiste en l'étude in vitro des phénomènes d'autoassemblage des molécules de collagène de type I en phases denses. Dans un premier temps nous nous sommes consacrés à l'étude de solutions colloïdales de collagène solubilisé en milieu acide. Nous avons étudié la transition isotrope/cholestérique ainsi que la structure de la phase cristal-liquide obtenue à l'aide de la microscopie optique à lumière polarisée et de la diffusion des rayons X aux petits angles. De plus, nous avons décrit les propriétés rhéologiques de ces solutions à l'aide d'expériences en régime oscillant

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14

Vigier, Sylvain. "MATRICES FIBRILLAIRES DENSES DE COLLAGÈNE : MATÉRIAUX POUR LA RÉPARATION OSSEUSE ET L'ÉTUDE D'OSTÉOBLASTES EN TROIS DIMENSIONS." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2008. http://tel.archives-ouvertes.fr/tel-00574654.

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L'os, tissu conjonctif minéralisé, assure les fonctions de protection, de support et de motilité. De nombreuses pathologies osseuses requièrent l'utilisation d'implants naturels ou synthétiques et le vieillissement de la population accroît cette demande. La thèse a eu pour objet d'évaluer les potentiels de reconstruction osseuse de matériaux préparés à partir de solutions de collagène de concentration moyenne (5mg/mL) et haute (40mg/mL). Ces matériaux fibrillaires, simple à façonner, ont été caractérisés par microscopie photonique et électronique et comparés aux éponges de collagène déjà utili

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15

Maselli, Andrea. "Avaliação do efeito de diferentes tratamentos sobre a degradação do colágeno e progressão da lesão de cárie radicular : estudo IN VITRO /." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152573.

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16

Stanley, Denise Y. "Teaching Is My Art Now." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/2653.

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This arts-informed inquiry is grounded in the lived experiences of five self-proclaimed artists including the researcher, who have turned to careers in teaching at varying stages of their lives. The stories of their transitions and evolving identities as both artists and teachers provide the investigative focus for this study. Although this research is relevant to teachers more generally, it specifically focuses on those who have chosen to teach Visual Arts. Particularly suited to a postmodern, arts-informed inquiry, the diverse forms of knowing that create our everyday experiences are acknow

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17

Stanley, Denise Y. "Teaching Is My Art Now." University of Sydney, 2008. http://hdl.handle.net/2123/2653.

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Doctor of Philosophy<br>This arts-informed inquiry is grounded in the lived experiences of five self-proclaimed artists including the researcher, who have turned to careers in teaching at varying stages of their lives. The stories of their transitions and evolving identities as both artists and teachers provide the investigative focus for this study. Although this research is relevant to teachers more generally, it specifically focuses on those who have chosen to teach Visual Arts. Particularly suited to a postmodern, arts-informed inquiry, the diverse forms of knowing that create our everyda

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18

Cornet, Sylvie. "Evolution de la lame basale glomerulaire au cours de la nephrogenese et de la senescence, chez le rat." Paris 6, 1988. http://www.theses.fr/1988PA066166.

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19

Metzmacher, Iris [Verfasser]. "Enzymatic degradation and drug release behavior of dense collagen implants / vorgelegt von Iris Metzmacher." 2005. http://d-nb.info/977770176/34.

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20

(5929535), Kevin P. Buno. "Cell-Matrix Tensional Forces Within Cell-Dense Type I Collagen Oligomer Tissue Constructs Facilitate Rapid In Vitro Vascularization of Dense Tissue Constructs for Skin Engineering." Thesis, 2019.

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The skin provides protection and maintains homeostasis, making it essential for survival. Additionally, skin has the impressive ability to grow, as observed in children as they grow into adults. However, skin functions are compromised in large skin defects, a serious problem that can be fatal. The gold standard treatment is to use an autologous skin graft; however, due to donor site morbidity and limited availability, when full-thickness defects surpass 2% total body surface area (TBSA), skin substitutes are preferred. Unfortunately, current skin substitutes on the market: are slow to revascul

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