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Journal articles on the topic 'Dental Formulation'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Dipak, R. Kale1* Ram B. Ingle2 Priyanka A. Narode3 Paavanraj B. Lodwal4 Vaishnavi N. Borhade5. "Research On Preparation, Evaluation And Comparison Of Herbal Toothpaste With Marketed Herbal Toothpaste." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 337–45. https://doi.org/10.5281/zenodo.12662136.

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In current scenario in oral dental care with use of herbal toothpaste containing natural ingredients are moreacceptable in public belief than chemical based synthetic formulations due to their safety and efficacy inreducing dental caries, and preventing other dental issues to which this generation is prone to. In this formulationwe utilizes aloe vera gel, clove oil, neem powder, pomegranate peel powder and trikatu which are not yet usedby any other research work. These extracts possess many activities like anti-ulcer, anti-caries, anti- bacterial,wound healing along with which it imbibes certa

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2

S.Janani, S.P.Senthil, and R.Senthamarai. "Formulation and Evaluation of Antimicrobial Mucoadhesive Dental Gel of Aerial Root of Ficus Benghalensis L to Enhance the Therapeutic Activity using Clove Oil." International Journal of Innovative Science and Research Technology 7, no. 5 (2022): 1066–72. https://doi.org/10.5281/zenodo.6655177.

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The main purpose of the research is to develop and evaluate a dental gel containing a herbal medicine for the management of toothache. The ethanolic extract of aerial root of Ficus benghalensis was prepared and it was evaluated for organoleptice properties, pH and phytochemical screening. Antimicrobial activity of the extract was done against streptococcus mutans using well diffusion method. The gel was prepared using Carbopol, propylene glycol and clove oil as a permeation enhancer. Six gel formulations were prepared at two different grades and various concentration of Carbopol. The formulati

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Firdos Sultana, Firdos Sultana. "Formulation and Evaluation of Herbal Toothpaste." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 2138–46. https://doi.org/10.35629/4494-100221382146.

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The herbal toothpaste is more acceptable in public opinion than chemical-based synthetic formulations in the current oral dental care scenario due to their safety and efficacy in reducing dental caries and preventing other dental disorders to which this generation is prone. In this composition, we used Pomegranate peel powder. It has an anti-microbial, anti-bacterial, antiinflammatory, anti-plaque, and anti-oxidant properties. The toothpaste were evaluated to determine important physical characteristics such as pH, abrasiveness, cleaning ability, spreading ability, foaming ability, and anti-mi

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Jagdishsingh, Mr Nikumbh Gaurav. "Formulation and Evaluation of Herbal Toothpaste." International Journal for Research in Applied Science and Engineering Technology 10, no. 6 (2022): 4312–17. http://dx.doi.org/10.22214/ijraset.2022.44940.

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Abstract: Neem, “the bitter gem” is one of the most valued trees with many medicinal applications. The scientific name of neem is Azadirachta indica and belongs to Meliaceae family. It is the world’s most studied tree in the world and most promising one in the 21st century. Every part of the tree has medicinal value, such as flowers, leaves, neem cake, fruits and seed oil. Almost 300 different phytochemicals have been found in neem tree with versatile application. The aqueous and alcoholic leaf extract of neem is accounted for to have different pharmacological activities . In current situation

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Ghosh, Soma, Gopa Roy, and Biswajit Mukherjee. "Dental Mold: A Novel Formulation to Treat Common Dental Disorders." AAPS PharmSciTech 10, no. 2 (2009): 692–702. http://dx.doi.org/10.1208/s12249-009-9255-9.

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Arief, Maryam Jamila, Fariani Fariani, Muhammad Irsal, and A. Mumtihannah Mursyid. "Formulasi dan Evaluasi Serum Gigi Ekstrak Etanol Siwak (Salvadora persica L.)." Jurnal Sains dan Kesehatan 5, no. 2 (2023): 198–204. http://dx.doi.org/10.25026/jsk.v5i2.1724.

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Dental health is a common problem in society. Traditionally, siwak is used to prevent bleeding gums and has antimicrobial effects. In this study, a tooth serum was made from ethanol extract of siwak and its preparations were evaluated and its antibacterial effect was tested. The method used in this research was experimental and three formulations were made with different concentrations of ethanol extract of siwak, formulation 1 (21%), formulation 2 (42%), and formulation 3 (63%). The results of the preparation evaluation showed that the three formulations were not significantly different compa

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Shanthi, M. V.* Anaswara B. Manjusha C. P. Aadiya Krishna Aiswarya. M. Ganga Jayachandrann. "Formulation Development and Evaluation of Herbal Tooth Paste." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 1352–76. https://doi.org/10.5281/zenodo.14382608.

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Herbal toothpaste with natural ingredients is more acceptable in public opinion than chemical-based synthetic formulations in the current oral dental care scenario due to their safety and efficacy in reducing dental caries and preventing other dental disorders to which this generation is prone. In this composition, we use Clove oil, Tulsi oil, Mango leaf powder, all of which have never been used together before in any research. These extracts have anti-ulcer, anti-caries, anti- bacterial, as well as certain unique properties including anti-oxidant and anti-fungal. The physicochemical evaluatio

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Yogesh kumar dewangan, Vikas dewangan, Chirag jain, Nikita Sinha, and Bhumika chandrakar. "Formulation and evaluation of toothpaste for sensitivity." International Journal of Biological and Pharmaceutical Sciences Archive 7, no. 2 (2024): 041–49. http://dx.doi.org/10.53771/ijbpsa.2024.7.2.0039.

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Toothpastes are complex mixtures of abrasives and surfactants; anticaries agents, such as fluoride; tartar control ingredients; pH buffers; humectants (to prevent dry-out and increase the pleasant mouth feel); and binders, to provide consistency an shape. Binders keep the solid phase properly suspended in the liquid phase to prevent to the separation of the liquid phase out of the toothpaste. The dental paste preparations of clove oil tooth paste are designed using different bases for treatment of gingivitis and properties and other dental plaque. During our physicochemical evaluation studies,

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Kida, Dorota, Tomasz Konopka, Kamil Jurczyszyn, and Bożena Karolewicz. "Technological Aspects and Evaluation Methods for Polymer Matrices as Dental Drug Carriers." Biomedicines 11, no. 5 (2023): 1274. http://dx.doi.org/10.3390/biomedicines11051274.

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The development of polymer matrices as dental drug carriers takes into account the following technological aspects of the developed formulations: the composition and the technology used to manufacture them, which affect the properties of the carriers, as well as the testing methods for assessing their behavior at application sites. The first part of this paper characterizes the methods for fabricating dental drug carriers, i.e., the solvent-casting method (SCM), lyophilization method (LM), electrospinning (ES) and 3D printing (3DP), describing the selection of technological parameters and poin

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Vranić, Edina, Amela Lačević, Aida Mehmedagić, and Alija Uzunović. "Formulation ingredients for toothpastes and mouthwashes." Bosnian Journal of Basic Medical Sciences 4, no. 4 (2004): 51–58. http://dx.doi.org/10.17305/bjbms.2004.3362.

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In order to achieve the multi-claim products required for the dental care category, it is necessary for the formulator to use a variety of different ingredients. This places a number of demands on the development process. Innovations in the areas of pharmaceutical technology have contributed to the formulation of the products having superior efficacy as well as other attributes that may contribute to clinical response and patient acceptability. Improved clinical efficacy and tolerability, along with conditioning signals, should encourage patient compliance with oral hygiene further complementi

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Lestari, Nanda Revita Dwi, and Sari Edi Cahyaningrum. "Synthesis and Characterization of Hydroxyapatite-Nanosilver as Anti Bacteria that Cause Dental Caries." Indonesian Journal of Chemical Science 11, no. 1 (2022): 33–40. http://dx.doi.org/10.15294/ijcs.v11i1.51070.

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The formation of dental caries is the result of the activity of Streptococcus mutans bacteria. Various attempts have been done to prevent dental caries. One of them is using oral preparations containing antibacterial compounds Hydroxyapatite-NanoSilver which is an active ingredient that can provide antimicrobial effects to prevent dental caries. This study aims to synthesize and characterize nanosilver hydroxyapatite as an antibacterial that causes dental caries. Physicochemical characterization and antibacterial test towards Streptococcus mutans bacteria with the active ingredient hydroxyapat

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Salazar, Austyn, Natalie Anderson, and Jeffrey Stansbury. "Formulating Mechanically Robust Composite Restorative Materials for High Performance." Journal of Functional Biomaterials 16, no. 3 (2025): 101. https://doi.org/10.3390/jfb16030101.

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Although dental resin composite restoratives offer a widely used direct-placement treatment option aimed at replacing the form and function of a natural tooth, there are several clinically relevant performance aspects of these materials that can be improved. The formulation of the resin matrix phase of dental composites for high-efficiency photopolymerization leading to polymers with excellent mechanical properties has always been a challenge that is addressed here through the use of structurally new and more reactive monomers as well as the formation of polymer networks that incorporate non-c

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G. V., Radha, GANESH SAI MYNENI, Sunayana N, Soujanya G. V. R. L., and Charan K. "Formulation and Evaluation of Lignocaine Hydrochloride Proniosomes Loaded Orabase for Dental Anaesthesia." Journal of Drug Delivery and Therapeutics 11, no. 3-S (2021): 27–34. http://dx.doi.org/10.22270/jddt.v11i3-s.4866.

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The aim of this research is to prepare and evaluate lignocaine HCl Proniosomal orabase for enhanced permeation and prolonged dental anaesthesia effect. Objective: Various lignocaine proniosomal gels were formulated employing various surfactants. Methods: The formulations were scrutinized for entrapment efficiency, optical microscopy, in-vitro diffusion and release studies, mucoadhesive strength, ex-vivo permeation studies and drug – excipient interactions were determined by FTIR spectroscopy. Results: span 80 was found to be superior and significant for loading in to orabase. Considering the b

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*Prathamesh, S. Masne, Vinod Chaware Prof., Shivshankar D. Mhaske Dr., Mehta Ganesh, Kulkarni Vedangi, and Kirmirwar Aditya. "FORMULATION AND EVALUATION OF HERBAL MOUTHWASH." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 1192–209. https://doi.org/10.5281/zenodo.15544073.

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Herbal mouthwash presents a natural alternative devoid of alcohol or sugar, known to be breeding grounds for bacteria causing halitosis. By sidestepping these elements, herbal mouthwashes serve as a proactive measure in oral hygiene. Moreover, herbal ingredients in these solutions often possess antibacterial properties, aiding in the prevention of oral infections. This contrasts with conventional mouthwashes, which typically contain alcohol and sugar, providing a fertile environment for bacteria to thrive and produce halitosis-causing byproducts. Thus, opting for herbal mouthwash offers a prom

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Kaur, Palwinder, Manish Vyas, and Surajpal Verma. "Dental Caries: A Review on Etiology, Therapeutic Approaches, Novel Formulations, and Marketed Preparations." ECS Transactions 107, no. 1 (2022): 8035–48. http://dx.doi.org/10.1149/10701.8035ecst.

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Demineralization of dental enamel (dental caries) are widely prevalent throughout the world. According to the Global Oral Health Data Bank, this prevalence varies from 49% to 83% across different countries. Dental caries are a polyfactorial disease that still needs major pharmaceutical interventions to alleviate its prevalence. This paper delineates the latest understanding of pathological and protective factors associated with caries development. Based on the current knowledge of etiological factors, many therapeutic classes have been traversed since the past to decrease the severity of the d

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Abhijit, Hon* Vaishnavi Kendre Sakshi Desai Aditya Gangurde Amol Mohan Rohini Wagh. "Formulation And Evaluation of Herbal Mouthwash of Piper Betle." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 5017–29. https://doi.org/10.5281/zenodo.15557284.

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Herbal mouthwash emerges as a powerful, nature-based alternative to conventional chemical formulations, offering effective oral hygiene without the risk of harmful side effects. Infused with potent medicinal ingredients such as Honey, Amla (Emblica officinalis), Nagarvel (Piper betle), and Guava (Psidium guajava) leaves, this formulation harnesses the antimicrobial, anti-inflammatory, and antioxidant properties of traditional Ayurvedic botanicals. These natural agents work synergistically to reduce dental plaque, combat oral pathogens, soothe gum inflammation, and provide long-lasting freshnes

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S Dixit, Anagha, Soumya Saraswathi M, and Subrahmanya P. "PHARMACEUTICO ANALYTICAL STUDY ON GUNJA -ASHWAGANDHA DENTAL GEL – A MODIFIED FORMULATION FROM HARAMEKHALA." International Ayurvedic Medical Journal 12, no. 04 (2024): 722–26. http://dx.doi.org/10.46607/iamj0212042024.

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Dental caries is a chronic infectious condition caused by tooth-adherent cariogenic bacteria, primarily Streptococcus mutans. A common oral disease hinders achieving and maintaining oral health in all age groups. Because of dental caries, teeth lose their strength and may form cavities if not controlled. Ayurveda explains many Krimighna Dravyas, which will help provide a solution for all Krimija Vyadhis. Haramekhala is one of the ancient Ayurvedic texts written by Mahuka between the 6th and 11th centuries AD. This book explains different formulations for the diseases of oral cavities in the fo

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Dănilă, Alexandra-Ioana, Stefania Dinu, Daniel Pop, et al. "CHARACTERIZATION AND BIOSAFETY PROFILE OF EUGENOL INCORPORATED IN IRON OXIDE NANOPARTICLES." Romanian Journal of Oral Rehabilitation 16, no. 3 (2024): 442–52. https://doi.org/10.62610/rjor.2024.3.16.46.

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Aim of the study Eugenol, a phenolic compound commonly found in plants like clove and bay leaves, has garnered significant attention in the field of dentistry due to its diverse pharmacological properties. In dentistry, eugenol is frequently employed in various forms, such as in polymerized cement with zinc oxide for restorative purposes. Its applications extend to endodontic cements like zinc oxide-eugenol formulations, which are commonly used in dental procedures. So far, according to our knowledge, no study in the literature has approached formulations based on iron oxide nanoparticles and

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Deepika, Bairagee* Ankit Jain Sweta Kulkarni Arun K. Gupta. "DEVELOPMENT AND EVALUATION OF PERIDONTAL STRIPS OF ORNIDAZOLE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 1290–300. https://doi.org/10.5281/zenodo.1195061.

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The aim of the present study was to develop site specific drug delivery of ornidazole for the treatment of periodontitis which has excellent activity against anaerobic microorganisms. The formulations were prepared by utilizing polymers such as PEO and gellan gum by solvent technique with the used of plasticizer (PEG-400). The calibration curve of ornidazole was developed in PBS pH 6.8 at 317nm in the range of 2 to 20 µg/ml. Compatibility study were carried out by FT-IR and Differential scanning Colorimetry. The formulations were evaluated for thickness, folding endurance, weight variati

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Senthilkumar, K. L., S. Venkateswaran., A. Vasanthan, et al. "Formulation development and evaluation of novel herbal toothpaste from natural source." International Journal of Pharmaceutical Chemistry and Analysis 9, no. 1 (2022): 17–21. http://dx.doi.org/10.18231/j.ijpca.2022.003.

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Herbal toothpaste with natural ingredients is more acceptable in public opinion than chemical-based synthetic formulations in the current oral dental care scenario due to their safety and efficacy in reducing dental caries and preventing other dental disorders to which this generation is prone. In this composition, we use aloe Vera gel, clove oil, Neem powder, pomegranate peel powder, all of which have never been used before in any research. These extracts have anti-ulcer, anti-caries, anti-bacterial, and wound-healing properties, as well as certain unique properties including anti-cancer and

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21

Walia, Chakshu, Amit Bhatia, Puneet Sudan, and Vikrant Abbot. "Optimization, in vitro drug release, and ex vivo permeation study of etoricoxib-loaded polymeric dental films." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 393. https://doi.org/10.59467/ijhc.2025.35.393.

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Etoricoxib is a popular synthetic non-steroidal anti-inflammatory drug with analgesic and anti-inflammatory effects. The goal of the current work is to optimize etoricoxib-loaded dental films for quick as well as prolonged action. The dental films were prepared by solvent evaporation method. The hydroxypropyl methylcellulose (HPMC-E15) and Eudragit (RL-100) were selected as main polymers for the preparation of films. The optimization of films was done using Central Composite Design with 2 factors at three levels. From the results, F9 was found to be the best fit formulation among all the prepa

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Uzbelger Feldman, Daniel, Billy B. Laun, Chirag Patel, Sonal V. Pande, and Sai H. S. Boddu. "A Buffered Local Anesthetic Without Epinephrine: Development, Characterization, and In Vivo Efficacy and Toxicity Analysis." Pharmaceutics 16, no. 8 (2024): 1058. http://dx.doi.org/10.3390/pharmaceutics16081058.

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Lidocaine hydrochloride (HCl) 2% with 1:100,000 epinephrine (LW/E) is widely used to prevent pain during dental procedures and has been associated with injection sting, jittering effects, slow onset, and a bitter aftertaste. Since LW/E’s introduction in 1948, no significant modifications have been proposed. This study aims to design and characterize an improved dental lidocaine HCl injectable formulation without epinephrine (LW/O/E) via buffers, sweeteners, and amino acids. LW/O/E injections were prepared with pH and osmolality values of 6.5–7.0 and 590–610 mOsm/kg. Using the electronic tongue

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Silva, Nelson, and Elfrides E. S. Schapoval. "Spectrophotometric determination of etidocaine in pharmaceutical (dental) formulation." Journal of Pharmaceutical and Biomedical Analysis 29, no. 4 (2002): 749–54. http://dx.doi.org/10.1016/s0731-7085(02)00180-2.

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Wee, Alvin G., Wei-Yi Chen, and William M. Johnston. "Color formulation and reproduction of opaque dental ceramic." Dental Materials 21, no. 7 (2005): 665–70. http://dx.doi.org/10.1016/j.dental.2004.09.003.

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Divya, Maluskar* Dr. Tambe S. E. "Formulation, Development and Evaluation of Effervescent Tooth Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2135–50. https://doi.org/10.5281/zenodo.15397743.

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Tooth tablets are small, bite-sized chewable tablets that can be chewed into a paste and they are showing a similar effect as traditional oral toothpaste. The main aim is to provide a convenient and effective oral care solution. Biomin F a fluoride releasing compound is known for its ability to remineralize enamel and protect against dental caries. The objective of this study was design an effervescent tablet incorporating Biomin F, which would release fluoride ions in a controlled manner when dissolved in water, thereby ensuring the target delivery to the teeth. The powder blend was evaluated

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Silva, Thais M., Thays C. A. Bolzan, Marcos S. Zanini, et al. "Development and Evaluation of a Novel Oral Mucoadhesive Ointment Containing Pomegranate Peel Extract as an Adjuvant for Oral Hygiene of Dogs." Journal of Veterinary Dentistry 37, no. 3 (2020): 133–40. http://dx.doi.org/10.1177/0898756420973470.

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Herbal therapies are used worldwide to treat a variety of health conditions, including dental conditions in veterinary medicine. In this context, the use of medicinal plant-based formulations as potential therapeutics and preventatives in veterinary dentistry is worth highlighting. The objective of the present study was to develop a mucoadhesive ointment formulation, named orabase, that contained pomegranate extract for use in the oral cavity of dogs, with the aim of improving their oral hygiene. The hydroalcoholic extracts of pomegranate peels was incorporated into the orabase in 3 different

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Sashi, Bhusan, Tangri Pranshu, Kumar Ganesh, and Kothiyal Preeti. "A Review on Aspects of Dental Drug Delivery." International Journal of Trend in Scientific Research and Development 2, no. 4 (2018): 1537–43. https://doi.org/10.31142/ijtsrd12771.

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Buccal mucosa can be used for local drug delivery as in for periodontitis, dental caries or for oral mucosal drug delivery as for analgesia or transmucosal systemic effect or delivery of biotechnological products like proteins and peptides. This review article is an overview of buccal drug delivery systems encompassing a review of oral mucosa, formulation considerations, theories and mechanism of mucoadhesion, different mucoadhesive formulations for buccal drug delivery and active ingredients delivered via the buccal route. The drugs which have local action or those which have maximum absorpti

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Xie, Sheng-Xue, Kyle Boone, Sarah Kay VanOosten, et al. "Peptide Mediated Antimicrobial Dental Adhesive System." Applied Sciences 9, no. 3 (2019): 557. http://dx.doi.org/10.3390/app9030557.

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The most common cause for dental composite failures is secondary caries due to invasive bacterial colonization of the adhesive/dentin (a/d) interface. Innate material weakness often lead to an insufficient seal between the adhesive and dentin. Consequently, bacterial by-products invade the porous a/d interface leading to material degradation and dental caries. Current approaches to achieve antibacterial properties in these materials continue to raise concerns regarding hypersensitivity and antibiotic resistance. Herein, we have developed a multi-faceted, bio-functionalized approach to overcome

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Vapninder, Kaur. "Indian Dental Workforce: The Need of Getting It Back To Action." International Healthcare Research Journal 3, no. 4 (2019): 138–40. https://doi.org/10.26440/IHRJ/0304.07260.

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India encounters a severe gap in the number of working dental professionals to that required. Population explosion and development are on the peak whereas good dental health is lacking behind. India has got numerous dental institutions, governing dental bodies, established dental associations but inadequate dental workforce, poor health literacy and substandard oral health status. This obviously implies that we are somewhere something is going wrong that is hindering the country from achieving the Millennium Development Goals. The need of the hour is to focus on the concerned issues, formulati

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Miranda, Michele, Francesco Gianfreda, Graziana Molica, Mirko Martelli, Marco Gargari, and Patrizio Bollero. "The Use of Cyanoacrylate and Glubran in Dentistry: A Review of Clinical Applications and Outcomes." Materials 18, no. 11 (2025): 2642. https://doi.org/10.3390/ma18112642.

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Cyanoacrylate-based adhesives have gained increasing attention in dentistry for their rapid polymerization, biocompatibility, and antimicrobial activity. This review analyzes the clinical use of cyanoacrylate adhesives—particularly the Glubran II formulation—in dental procedures, including wound closure, tissue management, and bleeding control. A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science databases for studies published between 2000 and 2024, using specific inclusion criteria (clinical and in vitro studies focusing on dental applications of cyanoacr

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Ganu, Gayatri, and Dheeraj Nagore. "Therapeutic Potential of Herbal Blend and Essential Nutrients Formulation in Promoting Chondrogenic Differentiation: A Study Using Human Dental Pulp Stem Cells." International Journal of Health Sciences and Research 14, no. 11 (2024): 323–28. http://dx.doi.org/10.52403/ijhsr.20241137.

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Background: Osteoarthritis remained a significant healthcare challenge, with current treatments primarily focusing on symptom management rather than chondrocyte regeneration. Human dental pulp stem cells (hDPSCs) emerged as a promising cell source for chondrocyte regeneration. This study investigated the potential of herbal blend and essential nutrients formulation to enhance chondrogenic differentiation of hDPSCs and its implications for osteoarthritis treatment. Materials and Methods: The researchers evaluated herbal blend and essential nutrients formulation effects on hDPSCs across concentr

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Grimling, Bożena. "FORMULATION AND CHARACTERISATION OF MUCOADHESIVE DENTAL APPLICATIONS CONTAINING BENZYDAMINE HYDROCHLORIDE." Progress on Chemistry and Application of Chitin and its Derivatives 26 (September 30, 2021): 71–79. http://dx.doi.org/10.15259/pcacd.26.006.

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The aim of this research was to develop a bioadhesive film based on benzydamine hydrochloride incorporated into natural bioadhesive polymers with different quantities of chitosan and guar gum but utilising a plasticiser. The obtained gels were deaerated by sonification, formed and evaporated by hot air drying; then, the properties were evaluated. Guar gum had a great influence on mechanical properties of the films – dynamic viscosity, texture, elasticity, stretching robustness, swelling and blur time. The formulations were used to obtain mucoadhesive films containing 0.3% benzydamine hydrochlo

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Alfiya T A, Alfiya T. A., Ameera M. Ameera M, Beema Abbas Beema Abbas, Devika M. S. Devika M S, Asweel K. Moosa Asweel K Moosa, and Jilby Saju Jilby Saju. "Formulation and Evaluation of Mimosa Pudica Incorporated Toothpaste." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 929–37. https://doi.org/10.35629/4494-1001929937.

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Mimosa pudica known for its medical qualities, it has potential for use in toothpaste and other dental care products. Alkaloids, flavonoids, and tannins represent a few of its bioactive substances that have antibacterial, anti-inflammatory, and antioxidant properties that may help to improve dental health. According to studies, it may lessen plaque, dangerous germs, and gum inflammation, hence preventing gum disease and cavities. This study looks at the advantages of Mimosa pudica toothpaste, including its function in boosting gum health and fresh breath, as well as its safety and effectivenes

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Bontorim, Francisco Carlos, Milton Carlos Kuga, Sabrina Spinelli Cioffi, Marcus Vinicius Reis Só, Gisele Faria, and Jefferson Ricardo Pereira. "Effect of two formulations of 10% sodium ascorbate on fracture resistance of endodontically treated tooth submitted to dental bleaching with hydrogen peroxide associated titanium dioxide nanoparticles." Journal of Research in Dentistry 2, no. 1 (2014): 13. http://dx.doi.org/10.19177/jrd.v2e1201413-21.

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PURPOSE: This study evaluated the effect of 10% sodium ascorbate (10SA), in gel (10SAg) or aqueous solution (10SAs) formulations, on fracture resistance of endodontically treated tooth submitted to dental bleaching procedures with 15% hydrogen peroxide associated with titanium dioxide (15HP-TiO2) nanoparticles and photoactivated by LED-laser. MATERIAL AND METHODS: Forty maxillary premolars were endodontically-treated and embedded in acrylic resin up to the cement-enamel junction. The specimens were divided into four groups (n=10): G1 (negative control): no bleaching, coronal access restored wi

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Khandgaonkar, Madhuri, Bhagyashri Gayke, and Anjali Shinde. "Formulation and Evaluation of Polyherbal Toothpaste: To Overcome Oral Problems." International Journal for Research in Applied Science and Engineering Technology 11, no. 7 (2023): 1291–306. http://dx.doi.org/10.22214/ijraset.2023.54838.

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Abstract: Polyherbal toothpaste with natural ingredients is more acceptable in public opinion than chemical-based synthetic formulations in the current oral dental care scenario due to their safety and efficacy in reducing dental caries and preventing other dental disorders to which this generation is prone. In this composition, we use, clove, Neem, pomegranate peel , all of which have never been used before in any research. These extracts have anti-ulcer, anti-caries, anti-bacterial, and remedial properties, as well as certain unique properties including anti-cancer and anti-fungal. Herbal to

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Pandit, Ashlesha P., Vaibhav V. Pol, and Vinit S. Kulkarni. "Xyloglucan Based In Situ Gel of Lidocaine HCl for the Treatment of Periodontosis." Journal of Pharmaceutics 2016 (January 28, 2016): 1–9. http://dx.doi.org/10.1155/2016/3054321.

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The present study was aimed at formulating thermoreversible in situ gel of local anesthetic by using xyloglucan based mucoadhesive tamarind seed polysaccharide (TSP) into periodontal pocket. Temperature-sensitive in situ gel of lidocaine hydrochloride (LH) (2% w/v) was formulated by cold method. A full 32 factorial design was employed to study the effect of independent variables concentrations of Lutrol F127 and TSP to optimize in situ gel. The dependent variables evaluated were gelation temperature (Y1) and drug release (Y2). The results revealed the surface pH of 6.8, similar to the pH of sa

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S. Das, Miss Rachana, Mr Santoshnath R. Gosavi, and Miss Pranali S. Gavali. "A Review on Formulation and Evaluation of Dental Cones." International Journal of Pharmaceutical Research and Applications 09, no. 05 (2024): 624–35. https://doi.org/10.35629/4494-0905624635.

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Dental cones, particularly those formulated with biodegradable polymers and azithromycin dihydrate, offer a promising solution for localized drug delivery in periodontal therapy. These cones are designed to be inserted into periodontal pockets, providing a controlled release of medication to target bacteria and promote healing after tooth extractions. Periodontal diseases, such as periodontitis and gingivitis, destroy tooth-supporting tissues if left untreated. Traditional treatments like scaling, root planning, and systemic antibiotics have limitations, including bacterial resistance and inco

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Damle, Mrinalini C., Mangesh R. Bhalekar, Shivani Rao, and Mayuri Godse. "Formulation and Evaluation of Chewable Tablets of Pomegranate Peel Extract." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 318–21. http://dx.doi.org/10.22270/jddt.v9i4.3049.

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Nowadays, dental caries is one of major oral disease caused due to facultatively anaerobic, gram-positive Streptococcus mutans. Pomegranate peel powder extract is known to have activity against Streptococcusmutans. The ethanolic extract of pomegranate peel powder was tested against streptococcus mutans (MTCC 497t). The Minimum inhibitory concentrations was found to be 6.24 mg/ml. Chewable tablet containing 10х MIC of the pomegranate peel powder was tested by cup plate method for its antibacterial activity against Streptococcus mutans. The study concludes that pomegranate peel extract is a natu

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Ajay, kartik.K, Hiremath V., Priyanka R., Soni P., and Rao K. Purushotam. "Beclomethasone Tooth Paste for Dental Disorders." Global Journal of Research in Dental Sciences 2, no. 2 (2022): 30–35. https://doi.org/10.5281/zenodo.6511652.

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In the present work, it was planned to prepare therapeutic medicated dental pastes for treatment of periodontitis and oral thrush, which provides effective treatment. Stress was given on local action of the drug and to treat initial stages of periodontitis and oral thrush. Beclomethasonedipropionate was chosen model drug which was a corticosteroid which has a wide range of anti-inflammatory activity. The prepared dental pastes were subjected for various physicochemical parameters like PH, Spreadability, tube extrudability, uniformity of drug content and IR studies. For this study periodontal i

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R Shinde, Pranali. "Formulation and Evaluation of Dental Gel using the Guava Leaves with Clove Oil." International Journal of Science and Research (IJSR) 12, no. 5 (2023): 1715–25. http://dx.doi.org/10.21275/sr23517153223.

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Sharma, Ravinder, Vikas Gupta, Gunpreet Kaur, Anubhav, Pankaj Sharma, and Meena Garg. "An analysis of scientific evidences for design of an ideal herbal dental formulation." International Journal Of Community Medicine And Public Health 12, no. 7 (2025): 3414–22. https://doi.org/10.18203/2394-6040.ijcmph20252150.

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This study is an analysis of components of herbal tooth pastes to highlight important dental herbs for the development of an ideal formulation with evidence-based approach. In this study ten herbal toothpaste formulations were purchased from the market, codified and the herbs present in all were tabulated. A comparison of their established pharmacological actions has been made. As per analysis the requirement of analgesics and anti-inflammatory agents is not a daily requirement and adds to a question mark for their inclusion in the daily use toothpaste. Some of the toothpastes have not include

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Abdelbary, Ghada Ahmed, and Mona Hassan Aburahma. "Oro-dental mucoadhesive proniosomal gel formulation loaded with lornoxicam for management of dental pain." Journal of Liposome Research 25, no. 2 (2014): 107–21. http://dx.doi.org/10.3109/08982104.2014.941861.

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Sultan, Muhammad H., Shamama Javed, Osama Ali Madkhali, et al. "Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach." Molecules 27, no. 6 (2022): 1796. http://dx.doi.org/10.3390/molecules27061796.

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The present study aimed to develop a local dental nanoemulgel formulation of Nigella sativa oil (NSO) for the treatment of periodontal diseases. NSO purchased from a local market was characterized using a GC–MS technique. A nanoemulsion containing NSO was prepared and incorporated into a methylcellulose gel base to develop the nanoemulgel formulation. The developed formulation was optimized using a Box–Behnken statistical design (quadratic model) with 17 runs. The effects of independent factors, such as water, oil, and polymer concentrations, were studied on two dependent responses, pH and vis

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Radha, G. V., K. Trideva Sastri, P. Prathyusha, P. Bhanu, and Jampala Rajkumar. "FORMULATION AND EVALUATION OF ACECLOFENAC PRONIOSOME LOADED ORABASE FOR MANAGEMENT OF DENTAL PAIN." International Journal of Applied Pharmaceutics 10, no. 6 (2018): 204. http://dx.doi.org/10.22159/ijap.2018v10i6.29143.

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Objective: The main motive is to develop proniosomes loaded orabase for enhanced permeation and prolonged release of aceclofenac for oro dental conditions.Methods: Various aceclofenac (ACL) proniosomal gels were formulated employing various surfactants, span 60 was superior and significant for loading into orabase. The formulations were scrutinized for entrapment efficiency, optical microscopy, in vitro diffusion and release studies, mucoadhesive strength, ex-vivo permeation studies and drug-excipient interactions were determined by FTIR spectroscopy.Results: Considering best entrapment effici

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Nayak, Yashvant, Rishu Kumar, Harish Sharma, and Gyanesh Kumar Sahu. "A Review On Eugenol as a Key Component in Clove Oil Toothpaste: Benefits and Applications." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 12 (2024): 1–5. https://doi.org/10.55041/ijsrem40072.

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Clove oil has long been known for its analgesic, antibacterial, and anti-inflammatory qualities. It is extracted from the cloves of the Syzygium aromaticum plant. Clove oil has been used in toothpaste formulations and other oral health products because of these advantageous qualities. The formulation, efficacy, and advantages of clove oil toothpaste—which attempts to enhance gum health and dental hygiene—are examined in this study. Clove oil's active ingredients, such eugenol, have strong antibacterial properties against common oral infections, which helps to prevent plaque, gingivitis, and fo

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Mastiholimath, VS, PM Dandagi, AP Gadad, MB Patil, FV Manvi, and VK Chandur. "Formulation and evaluation of ornidazole dental implants for periodontitis." Indian Journal of Pharmaceutical Sciences 68, no. 1 (2006): 68. http://dx.doi.org/10.4103/0250-474x.22967.

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Agusta, Herma Fanani, Alfian Syarifuddin, Fitriana Yuliastuti, and Misya Putri Kurnia Pradani. "Baking Soda and Peroxide Formulation as Dental Whitening Gel." Urecol Journal. Part D: Applied Sciences 1, no. 1 (2021): 50–55. http://dx.doi.org/10.53017/ujas.56.

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Indonesian society began to make appearance as a primary need. Appearance becomes important for middle and upper social classes which reaches 60-70% in Indonesia. Researchers are trying to find a combination formula of two teeth whitening ingredients (Baking Soda and Peroxide). The study uses an experimental method, which is to make a dental gel with variety of gradient constituent formulas, including F1, F2, F3, F4, and F5. F5 is the most optimal formula with best stability test results among other. F5 with Peroxide concentration of 30% had teeth whitening activity of 38% by two months in vit

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Bowles, C. Q., R. G. Miller, C. C. Chappelow, C. S. Pinzino, and J. D. Eick. "Design, formulation, and evaluation of isocyanatoacrylate copolymer dental adhesives." Journal of Biomedical Materials Research 48, no. 4 (1999): 496–503. http://dx.doi.org/10.1002/(sici)1097-4636(1999)48:4<496::aid-jbm15>3.0.co;2-9.

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Buruiana, Emil C., Florentina Jitaru, Violeta Melinte, and Tinca Buruiana. "Effect of cinnamate comonomers on the dental formulation properties." Journal of Applied Polymer Science 127, no. 4 (2012): 2442–52. http://dx.doi.org/10.1002/app.37942.

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Virendra, Rajendrasing Pardeshi* Bhavesh Shahanu Patil Bhavesh Suresh Patil Bhumika Dilip Patil Gayatri Subhash Pardeshi Dipali N. Patel Ravindra Rohidas Patil. "Formulation And Evaluation of Herbal Gel for Dental Caries." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4581–89. https://doi.org/10.5281/zenodo.15537062.

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Periodontal diseases such as gingivitis and periodontitis remain widespread oral health issues, primarily caused by bacterial plaque accumulation, which leads to inflammation, infection, and tissue damage. With growing concerns over antibiotic resistance and the demand for safer, natural oral care products, this study aimed to develop and evaluate a herbal-based dental gel with enhanced antibacterial and analgesic properties. The formulation incorporated Carbopol 980 as a gelling agent, polyethylene glycol and glycerin as solubilizers, and preservatives including methylparaben and propylparabe

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