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Dissertations / Theses on the topic 'Denticola'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Bamford, Caroline V. "Treponema denticola interactions with host proteins." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434742.

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2

Bouchard, Dominique. "Caractérisation biochimique de l'intégrase de l'intégron de Treponema denticola." Thesis, Université Laval, 2006. http://www.theses.ulaval.ca/2006/23650/23650.pdf.

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3

Miller, Daniel Patrick. "CHARACTERIZATION OF COMPLEMENT EVASION OF THE PERIOPATHOGEN, TREPONEMA DENTICOLA." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3478.

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Periodontitis is a polymicrobially-induced, chronic inflammatory disease of the tissues that support and surround the tooth. While greater than 500 organisms are found in dental plaque, Treponema denticola is one of only a few species associated with disease. It has been hypothesized that oral bacteria disrupt host homeostasis through manipulation of the innate immune system. In this study, we examine the impact of binding and subsequent cleavage of factor H, a complement regulator, by T. denticola in the evasion and subversion of complement. The molecular interaction between the sole FH-bindi

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4

Patel, Dhara T. "ASSESSMENT OF A PREDICTED DIGUANYLATE CYCLASE IN TREPONEMA DENTICOLA." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5591.

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Periodontal disease is a progressive inflammatory condition that is characterized by the reabsorption of alveolar bone, the destruction of connective tissue, and edentulism. It is caused by a dysbiosis in the oral microbiome as a result of a shift from a Gram-positive aerobic bacterial population, to one that becomes more Gram-negative and anaerobic. Treponema denticola is thought to drive this diseased state based on its role as a keystone periopathogen. A major component of T.denticola’s invasiveness is its motility, which allows the spirochete to penetrate and disseminate through tissues. T

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5

Leung, Wai Keung. "Effects of Treponema denticola on an oral epithelial cell model." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0009/NQ34575.pdf.

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6

Tegels, Brittney. "Analysis of plasminogen binding to Treponema denticola, a key periopathogen." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/556.

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Periodontitis is a chronic inflammatory disease that affects over 116 million adults in the United States. A shift in the normal microflora occurs as periodontal disease develops resulting in a larger number of Gram-negative anaerobes and spirochetes. An increase in the oral spirochete, Treponema denticola, is highly correlated with periodontal disease progression and severity. The ability of this periopathogen to thrive in the subgingival crevice is dependent on complement evasion mechanisms. Earlier analyses demonstrated that the primary mechanism of T. denticola serum resistance is bind

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7

Brissette, Catherine Ayn. "Interactions of oral spirochetes with the innate immune mechanisms of the gingival epithelium /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/9289.

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8

Juni, Sarkar. "Characterization of Hpk2-Rrp2, two-component regulatory system in Treponema denticola." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/268.

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Treponema denticola levels in the gingival crevice become elevated as periodontal disease develops. Oral treponemes may account for as much as 40% of the total bacterial population in the periodontal pocket. The stimuli that trigger enhanced growth of T. denticola and the mechanisms associated with the transmission of these signals remain to be defined. A hypothesis was set that the T. denticola ORFs tde1970 (histidine kinase) and tde1969 (response regulator) constitute a functional two component regulatory system that regulates, at least in part, responses to the changing environmental condi

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9

Haus, Karin. "Charakterisierung eines Flagellin-Genclusters aus Treponema maltophilum." Tönning Lübeck Marburg Der Andere Verl, 2008. http://d-nb.info/991846397/04.

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10

Gaibani, Paolo <1980&gt. "Role of treponema denticola in the pathogenesis and progression of Periodontal Disease." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2284/1/Paolo_Gaibani.pdf.

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11

Gaibani, Paolo <1980&gt. "Role of treponema denticola in the pathogenesis and progression of Periodontal Disease." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2284/.

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12

Yang, Po Fong. "Filamentous actin disruption and diminished inositol phosphate response in gingival fibroblasts caused by Treponema denticola." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0007/MQ40757.pdf.

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13

Rosario, Sarah. "Bacterial Selenoproteins: A Role in Pathogenesis and Targets for Antimicrobial Development." Doctoral diss., University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2655.

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Selenoproteins are unique proteins in which selenocysteine is inserted into the polypeptide chain by highly specialized translational machinery. They exist within all three kingdoms of life. The functions of these proteins in biology are still being defined. In particular, the importance of selenoproteins in pathogenic microorganisms has received little attention. We first established that a nosocomial pathogen, Clostridium difficile, utilizes a selenoenzyme dependent pathway for energy metabolism. Following this initial characterization, we demonstrate that this pathway is linked to productio

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14

Battikhi, Tulin. "Treponema Denticola outer membrane extract enhances the phagocytosis of collagen coated-beads by human gingival fibroblasts." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0026/MQ40753.pdf.

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15

Clark, Douglas Taylor. "An investigation of the metabolism of testosterone, 4 androstenedione, progesterone, corticosterone, cortisol and cholesterol by T. denticola." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249230.

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16

de, Carvalho Farias Bruna. "Ocorrência de periodontopatógenos em brasileiros portadores de periodontite crônica." Universidade Federal de Pernambuco, 2009. https://repositorio.ufpe.br/handle/123456789/8769.

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Made available in DSpace on 2014-06-12T23:02:15Z (GMT). No. of bitstreams: 2 arquivo969_1.pdf: 1672515 bytes, checksum: 57a925ef24be8c7dd06dd31514a160d4 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2009<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>O presente trabalho teve por objetivo avaliar a presença dos periodontopatógenos que formam o complexo vermelho (Tannerella forsythia (Tf), Porphyromonas gingivalis (Pg) e Treponema denticola (Td)) e o Aggregatibacter actinomycetemcomitans (Aa) em pacientes portadores de

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17

Tremblay, Guillaume. "Analyses des corrélations entre les concentrations d'IL-18 et de TLR4 soluble et la charge en bactéries parodontopathogènes chez les patients atteints de parodontite chronique." Master's thesis, Université Laval, 2014. http://hdl.handle.net/20.500.11794/25228.

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La parodontite est une infection polymicrobienne qui entraîne une inflammation du parodonte et provoque une destruction irréversible des tissus de soutien de la dent. Le but de cette étude était d'évaluer les concentrations des cytokines IL-18, IL-1β, IL-10, TNFα ainsi que celles des récepteurs Toll de type 2 (Toll-like receptor 2, TLR2) et 4 (TLR4) solubles dans le fluide créviculaire gingivale (FCG) et la salive d'une cohorte de patients atteints de parodontite. Ces concentrations ont été corrélées avec les paramètres cliniques de la parodontite et la quantité des bactéries Porphyromonas gin

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18

John, Cathy Nisha. "Association between CD4+T lymphocyte levels and "red complex" pathogens of chronic inflammatory periodontal disease in HIV-positive patients." University of the Western Cape, 2012. http://hdl.handle.net/11394/5117.

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Masters of Science<br>Background: Infection with HIV results in gradual loss of immunologic functions, especially those mediated by CD4+T helper cells with consequent impairment of the immune response leading to severe manifestations of periodontal disease. The lower the CD4+T lymphocyte cell count or the higher the level of immunosuppression, the higher the incidence of periodontal disease in those patients will be. Putative periodontopathic bacteria namely Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, commonly referred to as "red complex", and many other bacterial s

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19

SILVA, Natália da Silva e. "Periodontite em ovinos no estado do Pará: etiologia, aspectos epidemiologicos e clinico-patologicos." Universidade Federal do Pará, 2015. http://repositorio.ufpa.br/jspui/handle/2011/8329.

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Submitted by Cássio da Cruz Nogueira (cassionogueirakk@gmail.com) on 2017-05-05T11:38:15Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese_PeriodontiteOvinosEstado.PDF: 11749160 bytes, checksum: 07582d26b606607e8e1786f83ce34921 (MD5)<br>Approved for entry into archive by Edisangela Bastos (edisangela@ufpa.br) on 2017-05-09T20:27:18Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese_PeriodontiteOvinosEstado.PDF: 11749160 bytes, checksum: 07582d26b606607e8e1786f83ce34921 (MD5)<br>Made availa

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20

Reed, Lucas A. "The Effects of Amixicile, A Pyruvate Ferredoxin Oxidoreductase Inhibitor, on Oral Treponemes." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4184.

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Periodontal disease (PD) is a polymicrobial infection characterized by inflammation of the gingiva, alveolar bone resorption, and tooth loss (edentulism). Treponema denticola along with Porphyromonas gingivalis and Tannerella forsythia are among the “Red Complex” and are main etiological agents in PD. Treponemes are a member of the Spirochaeta phylum and are obligate anaerobes, that express pyruvate ferredoxin oxidoreductase (PFOR). The enzyme catalyzes the oxidation of pyruvate to acetyl-CoA and reduced ferredoxin. Amixicile is a novel bacteriostatic derivative of nitazoxanide and an inhibito

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21

Oliveira, Francisco Artur Forte. "Molecular analysis of oral bacteria in dental plaque, saliva and cardiac valve of patients with cardiovascular disease." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9733.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Over the past few years, there has been increasing evidence of the effect of the oral health over the general health of individuals, supported by a series of biological and epidemiological studies that show a relation between the mouth and many diseases, including cardiovascular diseases. Structural deficiencies and functional abnormalities of heart valves represent an important cause of cardiovascular morbidity and mortality in Brazil, and a few defects have

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22

Theodoropoulou, Angeliki. "Le denticulé, cet inconnu : les assemblages lithiques à denticulés du paléolithique moyen en Europe." Paris, Muséum national d'histoire naturelle, 2008. http://www.theses.fr/2008MNHN0002.

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Les assemblages du Paléolithique moyen à denticulés ne sont pas fréquents. L’étude comparative de tous les sites en Europe ayant livré une phase d’occupation riche en denticulés et l’étude détaillée des assemblages de 5 sites européens (abri Broullaud, grotte Tournal, abri Chadourne, abri Breuil et abri Romani) montre une grande diversité de ce type d’assemblage. Le contexte environnemental n’explique pas la forte fréquence des denticulés. En revanche, les supports des denticulés sont toujours plus épais, d’où parfois l’utilisation d’un « schéma opératoire » spécifique. La variabilité des type

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23

Rasch, Liam. "An ancestral gene network regulates continuous tooth regeneration and denticle development in elasmobranchs." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/8572/.

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Sharks and rays (elasmobranchs) regenerate their teeth via a novel system in which multiple teeth develop in advance of function as a dental conveyor belt. Given their ancestral phylogenetic position, extant elasmobranchs therefore provide ideal models to study the ancient state of gnathostome tooth regeneration (polyphyodonty). Despite this potential, they have received little attention, leaving a significant gap in knowledge. The research presented here addresses this by using suitable species of catshark and ray as comparative models to investigate conserved gene expression during elasmobra

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24

Thiébaut, Céline. "Le Moustérien à denticulésVariabilité ou diversité techno-économique." Phd thesis, Université de Provence - Aix-Marseille I, 2005. http://tel.archives-ouvertes.fr/halshs-00009633.

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Le Moustérien à denticulés, considéré comme l'un des faciès classiques du Moustérien, est soumis à un réexamen critique.<br />La mise au point préalable d'une méthodologie propre à l'étude des pièces encochées a permis de différencier les pseudo-outils des véritables pièces encochées et ainsi d'appréhender les caractéristiques techno-économiques de ces dernières.<br />L'étude de cinq ensembles lithiques (Les Fieux, Saint-Césaire Egpf, Hyène IVb1, Bison G et H) ainsi qu'une première analyse du matériel de Combe-Grenal c. 11 et les pièces retouchées de Mauran et La Borde montrent une certaine co

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25

"Caractérisation biochimique de l'intégrase de l'intégron de Treponema denticola." Thesis, Université Laval, 2006. http://www.theses.ulaval.ca/2006/23650/23650.pdf.

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26

Amin, Mohsen. "Actin-perturbing Activity of Treponema denticola Major Outer Sheath Protein (Msp) and Stress Fiber Formation/Stabilization by a Novel Peptide Conjugate Deduced from the Msp Sequence." Thesis, 2009. http://hdl.handle.net/1807/17724.

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The major outer sheath protein (Msp) is the most prominent surface antigen of the periodontal pathogen Treponema denticola. It mediates adhesion to extracellular matrix and dysregulation of cytoskeletal homeostasis of host cells. Disassembly of actin filaments and the coincident subcortical de novo synthesis of actin filaments in fibroblasts upon exposure to Msp were investigated with a barbed-end fluorescent labeling method. The functional impact of actin cytoskeleton disorganization was determined with a scratch wound migration assay in fibroblast monolayers and a videomicroscopy migration a

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27

Puthengady, Thomas Bina Agnes. "Effect of Treponema denticola major outer sheath protein on neutrophil functions in vitro." Thesis, 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=442034&T=F.

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28

Galimanas, Vaia Bailey. "Expression of the Treponema denticola dentilisin gene (prtP) and upstream genes in biofilm and planktonic cells under peptide-limiting conditions." 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=370336&T=F.

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29

Caldwell, Charles Edward. "The anaerobic physiology of Treponema denticola regulation of the arginine deiminase system, oxygen metabolism and enzymes protective against oxidative damage /." 1996. http://catalog.hathitrust.org/api/volumes/oclc/48128222.html.

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30

Roufegari, Nejad Arezou. "The association between caries and periodontal diseases." Thèse, 2012. http://hdl.handle.net/1866/8725.

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Objectifs: Le but de cette étude clinique était de comparer un groupe d’adultes ayant un parodonte sain avec un groupe d’adultes atteints de parodontite chronique en terme de risque carieux et mesures cliniques et microbiologiques de la carie. Méthodes: Quatre-vingt-seize individus ont été divisés en deux groupes en fonction de leur état de santé parodontal et ont été appariés pour l'âge, le sexe et l'origine ethnique. Trente-huit sujets étaient atteints de parodontite chronique définie comme ayant au moins quatre dents avec ≥ 1 site avec une profondeur de sondage ≥ 4 mm et une perte d'attach

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31

Barber, Maria Rosa Watson. "Evaluation of the BANA assay as a screening test for the detection of periodontopathic organisms in children (Treponema denticola, Bacteroides gingivalis, Bacteroides forsythus) a thesis submitted in partial fulfillment ... in pediatric dentistry ... /." 1989. http://books.google.com/books?id=KEo_AAAAMAAJ.

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32

Marshall, LJ. "The fin blue line : quantifying fishing mortality using shark fin morphology." Thesis, 2011. https://eprints.utas.edu.au/10721/1/Marshall_L_whole_thesis.pdf.

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Overfishing is a major global concern. Many of the worlds fish stocks are currently over exploited and require immediate action toward effective management and recovery strategies. Sharks are especially susceptible to overexploitation as they are generally slow growing, late maturing and produce few young. As large predators, sharks play an important, but poorly understood, role in marine food webs. As such, the ongoing exploitation of shark stocks is likely to cause detrimental and lasting ecological shifts within many marine systems. Within numerous fisheries, sharks are primarily targeted

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