Academic literature on the topic 'Deo Max (DM7)'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Deo Max (DM7).'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Deo Max (DM7)"
1
Getachew, Kuma Watiro. "Determination of the Specific Heat Capacities of car engine oil (Deo Max (DM7)/ 15W-40(oilibya)) and defreins brake fluid (total HBF 4 liquid) at low temperature (26-35oC) by using Calorimeter." J. of Advancement in Engineering and Technology 7, no. 3 (2020): 06. https://doi.org/10.5281/zenodo.3751590.
Full textAbstract:
The purpose of this study is to determine the specific heat capacities of car oils at low temperature (26-35oC). I used experimental method, setting my procedure and analysis the data by using excel and draw graphs by using MATLAB. I used water as the standard mean that first I tried to determine the specific heat capacity of water using colorimeter which is 4184J/kg oc but I determined 4020J/kg oc which is an error around 3.91% this has right to continue my experiment to the next oils by using the same ways. I obtained the specific heat capacity of Deo max 7 and HBF 4 is 4.4736 and 6.8556 J/kgoc respectively. Not all engine oils are suitable for engines. Owing the specific heat capacity of the oils is very important because increase the performance of engine as it increases temperature.
2
Román Calderón, Juan Pablo, Alicia Krikorian, and Carolina Palacio González. "Afrontamiento del cáncer: adaptación al español y validación del Mini-MAC en población colombiana." Avances en Psicología Latinoamericana 33, no. 3 (2015): 531. http://dx.doi.org/10.12804/revistas.urosario.edu.co/apl/a.3157.
Full textAbstract:
Objetivo: Adaptar el Mini-MAC al español y examinar sus propiedades psicométricas en pacientes oncológicos colombianos. Método: 126 pacientes oncológicos completaron la versión adaptada del Mini-MAC, la Escala de Ansiedad y Depresión Hospitalaria (HADS) y el cuestionario de Detección del Malestar Emocional (DME). Se obtuvieron estadísticos descriptivos, correlacionales y coeficientes de consistencia interna. Se realizó un análisis de componentes principales (ACP) y un análisis de secuencias mediante un modelo de ecuaciones estructurales. Resultados: Se obtuvo una solución factorial de cuatro factores: indefensión/desesperanza (ID), preocupación ansiosa (PA), evitación/negación (EN) y espíritu de lucha (EL). Los valores del ACP indicaron un adecuado ajuste del modelo, que explica el 58.9% de la varianza. Se encontraron correlaciones significativas entre ID y PA, y entre ID y EL. EN correlacionó significativa y positivamente con PA y EL. Las correlaciones entre las subescalas del Mini-MAC y HADS y DME fueron significativas. La fiabilidad de las subescalas fue superior a .6. ID y PA tienen un efecto positivo en la ansiedad, y negativo en el estado de ánimo, lo cual explica un 49% de la varianza. EN ejerció un efecto negativo en el estado de ánimo. En conjunto, ID, PA y EN explicaron un 39% de la varianza del estado de ánimo. Conclusión: La versión colombiana del Mini-MAC demostró su validez y fiabilidad, por lo que constituye una herramienta adecuada para la evaluación del afrontamiento en cáncer.
3
Chen, Yi, Haimei Qi, Jie Sun, et al. "Synergy Effect of High-Stability of VS4 Nanorods for Sodium Ion Battery." Molecules 27, no. 19 (2022): 6303. http://dx.doi.org/10.3390/molecules27196303.
Full textAbstract:
Sodium-ion batteries (SIBs) have attracted increasing interest as promising candidates for large-scale energy storage due to their low cost, natural abundance and similar chemical intercalation mechanism with lithium-ion batteries. However, achieving superior rate capability and long-life for SIBs remains a major challenge owing to the limitation of favorable anode materials selection. Herein, an elegant one-step solvothermal method was used to synthesize VS4 nanorods and VS4 nanorods/reduced graphene oxide (RGO) nanocomposites. The effects of ethylene carbonate/diethyl carbonate(EC/DEC), ethylene carbonate/dimethyl carbonate(EC/DMC), and tetraethylene glycol dimethyl ether (TEGDME) electrolytes on the electrochemical properties of VS4 nanorods were investigated. The VS4 nanorods electrodes exhibit high specific capacity in EC/DMC electrolytes. A theoretical calculation confirms the advance of EC/DMC electrolytes for VS4 nanorods. Significantly, the discharge capacity of VS4/RGO nanocomposites remains 100 mAh/g after 2000 cycles at a large current density of 2 A/g, indicating their excellent cycling stability. The nanocomposites can improve the electronic conductivity and reduce the Na+ diffusion energy barrier, thereby effectively improving the sodium storage performance of the hybrid material. This work offers great potential for exploring promising anode materials for electrochemical applications.
4
VandenBoer, T. C., A. Petroff, M. Z. Markovic, and J. G. Murphy. "Size distribution of alkyl amines in continental particulate matter and their online detection in the gas and particle phase." Atmospheric Chemistry and Physics Discussions 10, no. 11 (2010): 27435–77. http://dx.doi.org/10.5194/acpd-10-27435-2010.
Full textAbstract:
Abstract. An ion chromatographic method is described for the quantification of the simple alkyl amines: methylamine (MA), dimethylamine (DMA), trimethylamine (TMA), ethylamine (EA), diethylamine (DEA) and triethylamine (TEA), in the ambient atmosphere. Limits of detection (3σ) are in the tens of pmol range for all of these amines, and good resolution is achieved for all compounds except for TMA and DEA. The technique was applied to the analysis of time-integrated samples collected using a micro-orifice uniform deposition impactor (MOUDI) with ten stages for size resolution of particles with aerodynamic diameters between 56 nm and 18 μm. In eight samples from urban and rural continental airmasses, the mass loading of amines consistently maximized on the stage corresponding to particles with aerodynamic diameters between 320 and 560 nm. The molar ratio of amines to ammonium (R3NH+/NH4+) in fine aerosol ranged between 0.005 and 0.2, and maximized for the smallest particle sizes. The size-dependence of the R3NH+/NH4+ ratio indicates differences in the relative importance of the processes leading to the incorporation of amines and ammonia into secondary particles. The technique was also used to make simultaneous hourly online measurements of amines in the gas phase and in fine particulate matter using an Ambient Ion Monitor Ion Chromatograph (AIM-IC). During a ten day campaign in downtown Toronto, DMA, TMA+DEA, and TEA were observed to range from below detection limit to 2.7 ppt in the gas phase. In the particle phase, MAH+ and TMAH++DEAH+ were observed to range from below detection limit up to 15 ng m−3. The presence of detectable levels of amines in the particle phase corresponded to periods with higher relative humidity and higher mass loadings of nitrate. While the hourly measurements made using the AIM-IC provide data that can be used the evaluate the application of gas-particle partitioning models to amines, the strong size-dependence of the R3NH+/NH4+ ratio indicates that using bulk measurements and an assumption of internal mixing may not be appropriate.
5
VandenBoer, T. C., A. Petroff, M. Z. Markovic, and J. G. Murphy. "Size distribution of alkyl amines in continental particulate matter and their online detection in the gas and particle phase." Atmospheric Chemistry and Physics 11, no. 9 (2011): 4319–32. http://dx.doi.org/10.5194/acp-11-4319-2011.
Full textAbstract:
Abstract. An ion chromatographic method is described for the quantification of the simple alkyl amines: methylamine (MA), dimethylamine (DMA), trimethylamine (TMA), ethylamine (EA), diethylamine (DEA) and triethylamine (TEA), in the ambient atmosphere. Limits of detection (3σ) are in the tens of pmol range for all of these amines, and good resolution is achieved for all compounds except for TMA and DEA. The technique was applied to the analysis of time-integrated samples collected using a micro-orifice uniform deposition impactor (MOUDI) with ten stages for size resolution of particles with aerodynamic diameters between 56 nm and 18 μm. In eight samples from urban and rural continental airmasses, the mass loading of amines consistently maximized on the stage corresponding to particles with aerodynamic diameters between 320 and 560 nm. The molar ratio of amines to ammonium (R3NH+/NH4+) in fine aerosol ranged between 0.005 and 0.2, and maximized for the smallest particle sizes. The size-dependence of the R3NH+/NH4+ ratio indicates differences in the relative importance of the processes leading to the incorporation of amines and ammonia into secondary particles. The technique was also used to make simultaneous hourly online measurements of amines in the gas phase and in fine particulate matter using an Ambient Ion Monitor Ion Chromatograph (AIM-IC). During a ten day campaign in downtown Toronto, DMA, TMA + DEA, and TEA were observed to range from below detection limit to 2.7 ppt in the gas phase. In the particle phase, MAH+ and TMAH+ + DEAH+ were observed to range from below detection limit up to 15 ng m−3. The presence of detectable levels of amines in the particle phase corresponded to periods with higher relative humidity and higher mass loadings of nitrate. While the hourly measurements made using the AIM-IC provide data that can be used to evaluate the application of gas-particle partitioning models to amines, the strong size-dependence of the R3NH+/NH4+ ratio indicates that using bulk measurements may not be appropriate.
6
Vásquez Arroyo, Sheila Bertha, Ivonne Analí Roy García, Lubia Velázquez López, and Lourdes Gabriela Navarro Susano. "Impacto del estilo de vida en el descontrol glucémico en pacientes con diabetes mellitus tipo 2." Atención Familiar 26, no. 1 (2018): 18. http://dx.doi.org/10.22201/facmed.14058871p.2019.1.67712.
Full textAbstract:
<p><strong>Objetivo:</strong> determinar el impacto del estilo de vida y de sus diferentes componentes en el control glucémico de los pacientes con diabetes mellitus tipo 2 (dm2). <strong>Métodos:</strong> diseño transversal analítico, se llevó a cabo en una unidad de medicina familiar en la Ciudad de México, de agosto a octubre de 2015. Se incluyó a 330 participantes con dm2, de 20 a 60 años bajo tratamiento farmacológico. Se utilizó el Instrumento para Medir el Estilo de Vida en Diabéticos (Imevid). Para medir el control glucémico se utilizó hemoglobina glucosilada (HbA1c), se consideró control glucémico un nivel de Hb1Ac &lt;7%. Para conocer los factores de riesgo asociados a descontrol glucémico se realizó un modelo de regresión logística múltiple, el cual se ajustó por estilo de vida, comorbilidades, tiempo de evolución de la dm2 e índice de masa corporal (imc). <strong>Resultados:</strong> 70.3% (232) de los participantes se encontró en el grupo de edad de 51-60 años, 90.6% (299) presentó alguna comorbilidad, la hipertensión arterial sistémica fue la más frecuente. 48.8% (161) presentó sobrepeso y 14.8% (49) obesidad. 35.8% (118) de los participantes presentaron buen estilo de vida, 43.9% (145) se encontraba en control glucémico. La mediana de Hb1Ac en pacientes con mal estilo de vida fue de 9% en comparación con el grupo que tenía buen estilo de vida con 6.4%, (p&lt;0.001). El buen estilo de vida es un factor protector para control glucémico con un odds ratio (or) de 0.026. <strong>Conclusiones:</strong> el estilo de vida no saludable es un factor de riesgo para el descontrol glucémico. El estilo de vida, comorbilidades, tiempo de evolución de dm2 e imc explican 85.3% del descontrol glucémico.</p>
7
Mahdi, Amira F., Niall Ashfield, Neil T. Conlon, John Crown, and Denis M. Collins. "Abstract P3-07-16: Pre-clinical study of amcenestrant and HER2-targeted therapies in HER2+/ER+ breast cancer cell line models." Cancer Research 83, no. 5_Supplement (2023): P3–07–16—P3–07–16. http://dx.doi.org/10.1158/1538-7445.sabcs22-p3-07-16.
Full textAbstract:
Abstract Background: Up to 70% of HER2 over-expressing (HER2+) breast cancers also express estrogen receptor (ER). Dual targeting of HER2 and ER has shown pre-clinical and clinical benefit in HER2+/ER+ breast cancer. Rationale for these combinations is based on circumvention of resistance mediated by crosstalk between HER2 and ER signalling pathways. Fulvestrant is the only selective estrogen receptor degrader (SERD) approved by the FDA for the treatment of ER+ breast cancer. Development of alternative orally available SERDs with improved bioavailability, such as amcenestrant, is underway. The HER2-targeted tyrosine kinase inhibitors (TKIs) lapatinib, neratinib and tucatinib and the antibody drug conjugate T-DM1 are approved for the treatment of HER2+ breast cancer. This pre-clinical study aims to investigate the potential of combining the oral SERD amcenestrant with HER2-targeted therapies for the treatment of HER2+/ER+ breast cancer through identification of synergistic combinations. Methods: ER and HER2 expression levels were assessed in the HER2+/ER+ BT-474 and MDA-MB-361 cell lines by western blot. 5-day acid phosphatase-based assays were used to assess cell viability following treatment with neratinib, lapatinib, tucatinib, and T-DM1; alone and in combination with amcenestrant. All TKIs were commercially sourced, T-DM1 was obtained from Saint Vincent’s University Hospital. Amcenestrant was supplied by Sanofi. IC50 values were determined using Calcusyn, while matrix combination assays of the HER2-targeted therapies combined with amcenestrant were analysed using Combenefit software employing the Loewe model (LM) to determine synergy (Score &gt; 0) or antagonism (Score &lt; 0). All data are the result of a minimum of three independent experiments. Results: HER2 and ER expression was confirmed in the MDA-MB-361 and BT-474 cell lines. MDA-MB-361 cells express higher levels of ER and lower levels of HER2 and phosphorylated HER2 than BT474 cells. MDA-MB-361 exhibited a higher sensitivity to 1 µM amcenestrant alone (% cell viability = 53.3 ± 2.3 %) than the BT-474 (% viability = 85.3 ± 5%). A comparison of IC50 values for each TKI alone or in combination with 1 µM amcenestrant showed amcenestrant significantly lowered the IC50 values for neratinib and tucatinib in BT-474, and all three TKIs in MDA-MB-361 (Table 1). In matrix combination assays, all TKIs exhibited synergistic combinations, with the combination of neratinib and amcenestrant demonstrating the highest synergy values in MDA-MB-361 (LM max value = 25 ± 7) and in BT-474 (LM max value = 19 ± 7). The combination of amcenestrant and T-DM1 displayed additivity (LM value = 0) rather than synergy in the BT-474 cell line, likely due to the high potency of T-DM1 as a single agent. Conclusions: The combination of amcenestrant and HER2-targeting therapies such as neratinib shows potential as a dual-target therapeutic strategy for the treatment of HER2+/ER+ breast cancer and warrants further investigation. Table 1. IC50 values for TKIs alone and with the addition of 1 µM amcenestrant. Significance of chance in IC50 point calculated by Student’s T test, ns = p &gt; 0.05, * = p &lt; 0.05, ** = p &lt; 0.01, SD = standard deviation Citation Format: Amira F. Mahdi, Niall Ashfield, Neil T. Conlon, John Crown, Denis M. Collins. Pre-clinical study of amcenestrant and HER2-targeted therapies in HER2+/ER+ breast cancer cell line models [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P3-07-16.
8
Ruiz Morosini, María Lidia. "Simposio 12: Utilidad del monitoreo continuo y de los infusores en diabetes mellitus tipo 2." Revista de la Sociedad Argentina de Diabetes 56, no. 3Sup (2022): 78. http://dx.doi.org/10.47196/diab.v56i3sup.576.
Full textAbstract:
En los últimos años el advenimiento de nuevas tecnologías, como el monitoreo continuo de glucosa (MCG), ha impactado en el control glucémico y calidad de vida, dando una mirada integral que aporta muchos más datos como tendencia, variabilidad glucémica, hipoglucemias inadvertidas y patrones durante el sueño, ayunos prolongados, actividad física e intercurrencias. Aún así, en las personas con diabetes mellitus tipo 2 (DM2) las evidencias para recomendar el MCG-RT o el MCG-flash/EI fueron escasas, si bien se han publicado varios estudios como Mobile, Diamond y Optimize exponiendo el beneficio con logro de menor HbA1c e hipoglucemias, y mayor tiempo en rango. La fuerte evidencia de asociación entre el TIR y el coeficiente de variación con la enfermedad cardiovascular y la vulnerabilidad de placa plantean la importancia de optimizar el control en esta población.
 Las guías actuales consideran la indicación de MCG escaneado intermitente tipo flash a personas adultas con DM2 que reciben múltiples dosis de insulina diaria mal controlada, con hipoglucemia recurrente, deterioro de conciencia por hipoglucemia o discapacidad que impida el monitoreo capilar, aconsejando escaneo de al menos ocho veces al día.
9
Loibl, Sibylle, Max Mano, Michael Untch, et al. "Abstract GS03-12: Phase III study of adjuvant ado-trastuzumab emtansine vs trastuzumab for residual invasive HER2-positive early breast cancer after neoadjuvant chemotherapy and HER2-targeted therapy: KATHERINE final IDFS and updated OS analysis." Cancer Research 84, no. 9_Supplement (2024): GS03–12—GS03–12. http://dx.doi.org/10.1158/1538-7445.sabcs23-gs03-12.
Full textAbstract:
Abstract Background: Patients with HER2-positive early breast cancer (EBC) who have residual invasive disease after neoadjuvant chemotherapy + HER2-targeted therapy have a high risk of recurrence and death. The standard of care when KATHERINE was designed was continuation of the same HER2-targeted therapy in the adjuvant setting for 1 year. The primary analysis of KATHERINE in 2018 showed that the risk of recurrence of invasive BC or death was 50% lower with adjuvant ado-trastuzumab emtansine (T-DM1) than with trastuzumab. Methods: KATHERINE (NCT01772472/BO27938/NSABP B-50-I/GBG 77) is a phase III, open-label, global study of patients with centrally confirmed, HER2-positive (immunohistochemistry 3+ or in situ hybridization-positive) primary BC (T1–4, N0–3, M0) who received neoadjuvant chemotherapy + HER2-targeted therapy, which had to include a taxane and trastuzumab, followed by surgery, with pathologically documented residual invasive disease in the breast and/or axillary lymph nodes. Within 12 weeks of surgery, patients were randomized 1:1 to T-DM1 (3.6 mg/kg intravenously [IV] every 3 weeks [q3w]) or trastuzumab (6 mg/kg IV q3w) for 14 cycles. Randomization was stratified by clinical stage at presentation, hormone receptor status, single vs dual neoadjuvant HER2-targeted therapy, and pathologic nodal status after neoadjuvant therapy. Patients received radiotherapy and/or endocrine therapy per local standards. The primary endpoint was invasive disease-free survival (IDFS). We report the final IDFS analysis, which was to occur after ~384 events had been reported, and the preplanned second interim analysis of overall survival (OS); specified to occur at the same time. Results: With a median follow-up of 8.4 years (101 months), T-DM1 sustained the improvement in IDFS over trastuzumab (unstratified hazard ratio [HR] 0.54; 95% confidence interval [CI] = 0.44, 0.66; p &lt; 0.0001). Landmark 7-year IDFS rates were increased from 67.1% with trastuzumab to 80.8% with T-DM1; a difference of 13.7%. At clinical cutoff for the final IDFS analysis, 215 deaths had been reported. T-DM1 significantly reduced the risk of death by 34% compared with trastuzumab (unstratified HR 0.66; 95% CI = 0.51, 0.87; p = 0.0027). Deaths had occurred in 89/743 patients (12.0%) in the T-DM1 arm and 126/743 (17.0%) in the trastuzumab arm. Landmark 7-year OS rates were increased from 84.4% with trastuzumab to 89.1% with T-DM1; a difference of 4.7%. OS and IDFS benefits were seen across key subgroups. A low incidence of adverse events (AEs) related to study treatment or to study procedures was observed during the post-treatment period: Grade ≥3 related AEs occurred in 3/740 patients (0.4%) in the T-DM1 arm and 3/720 (0.4%) in the trastuzumab arm; serious related AEs, in 2/740 (0.3%) and 4/720 (0.6%), respectively. Related AEs classed as “cardiac disorders” were rare in both arms with extended follow-up. Conclusions: After 8.4 years (101 months) median follow-up, T-DM1 significantly improved OS in patients with HER2-positive EBC with residual invasive disease after neoadjuvant therapy. The IDFS benefit of T-DM1 was sustained in the intention-to-treat population with longer follow-up, and no new safety issues emerged. Cardiac toxicity was rare in both arms. T-DM1 is the first therapy to show improved survival post-surgery in patients with HER2-positive EBC with residual invasive disease after neoadjuvant therapy. Follow-up is ongoing for the final OS analysis. Citation Format: Sibylle Loibl, Max Mano, Michael Untch, Chiun-Shen Huang, Eleftherios Mamounas, Norman Wolmark, Adam Knott, Asna Siddiqui, Thomas Boulet, Beatrice Nyawira, Eleonora Restuccia, Charles Geyer. Phase III study of adjuvant ado-trastuzumab emtansine vs trastuzumab for residual invasive HER2-positive early breast cancer after neoadjuvant chemotherapy and HER2-targeted therapy: KATHERINE final IDFS and updated OS analysis [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr GS03-12.
10
Ponce Arellano, Francisco Javier, Jesús Texis Ramírez Jesús, and Daniela Solis Nepomuceno. "Efecto de una Intervención Educativa sobre la Percepción del Uso de Insulinas." Ciencia Latina Revista Científica Multidisciplinar 9, no. 1 (2025): 3726–37. https://doi.org/10.37811/cl_rcm.v9i1.16117.
Full textAbstract:
Introducción: En México la DM 2 es la principal causa de discapacidad por sus complicaciones, así como de años perdidos por muerte prematura y mortalidad, su prevalencia en cuanto a su diagnóstico aumentó de un 7% a un 8.9% entre los años 2006 y 2012. La mayoría de los pacientes tienen un mal control glucémico secundario a un rechazo de la insulina por creencias sobre el uso y aplicación. Por tal motivo es importante conocer cuál es el efecto de una intervención educativa en la percepción del uso de insulina en pacientes con diabetes tipo 2. Objetivo: Determinar el efecto de una intervención educativa en la percepción del uso de insulina en pacientes con diabetes tipo 2. Métodos: Se realizó en pacientes de la UMF 55 con diagnóstico de DM2, se les aplicó un cuestionario validado: el ITAS (Treatment Appraisal Scale) con un alfa de Cronbach de 0.89; que consta de 4 preguntas de percepción positiva y 16 preguntas de percepción negativa en una población de 280 pacientes. Resultados: Se utilizo Mc Nemar y se llegó a la conclusión que P es menor de 0.05 (0.0), por lo cual: La intervención educativa mejora la percepción del uso de insulina en pacientes con diabetes tipo 2. Conclusiones: Después de analizar los resultados se puede concluir que la intervención educativa mejora la percepción del uso de insulina en pacientes con DM2.
Dissertations / Theses on the topic "Deo Max (DM7)"
1
Schwaabe, Christian. "Freiheit und Vernunft in der unversöhnten Moderne : Max Webers kritischer Dezisionismus als Herausforderung des politischen Liberalismus /." München : Fink, 2002. http://www.gbv.de/dms/sub-hamburg/343883058.pdf.
Full text
2
Schüring, Michael. "Minervas verstoßene Kinder : vertriebene Wissenschaftler und die Vergangenheitspolitik der Max-Planck-Gesellschaft /." Göttingen : Wallstein-Verl, 2006. http://www.gbv.de/dms/bs/toc/505238543.pdf.
Full textAbstract:
Humboldt-Univ., Diss. u.d.T.: Schüring, Michael: Minervas verstoßene Kinder--Berlin, 2003, Vertreibung, Entschädigung und die Vergangenheitspolitik der Max-Planck-Gesellschaft.<br>Quellen- und Literaturverz. S. [376] - 409.
3
Albrecht, Michael. "Das System der US-amerikanischen Wohnungsfinanzierung : Fannie Mae und Freddie Mac als Instrumente staatlicher Wohnungspolitik /." Frankfurt am Main [u.a.] : Lang, 2004. http://www.gbv.de/dms/zbw/372974007.pdf.
Full text
4
Kohl, Ulrike. "Die Präsidenten der Kaiser-Wilhelm-Gesellschaft im Nationalsozialismus : Max Planck, Carl Bosch und Albert Vögler zwischen Wissenschaft und Macht /." Stuttgart : Steiner, 2002. http://www.gbv.de/dms/bs/toc/340080701.pdf.
Full text
5
Eriksson, Lina. "Economic man : the last man standing /." Göteborg : Göteborg University, Department of Political Science, 2005. http://www.gbv.de/dms/sub-hamburg/479310874.pdf.
Full text
6
Guennec, Brice-Emmanuel. "Rôle du filament desmine dans la physiopathologie cardiaque de la dystrophie musculaire de Duchenne." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS249.pdf.
Full textAbstract:
La dystrophie musculaire de Duchenne (DMD) est une maladie génétique rare affectant les muscles squelettiques et cardiaques, résultant d'une mutation du gène de la dystrophine, une protéine musculaire essentielle. La souris mdx est largement utilisée comme modèle de recherche pour la DMD. Néanmoins, la gravité de la maladie chez la souris est nettement plus légère que chez l'homme. Cette divergence pourrait potentiellement être attribuée à l'expression accrue de diverses protéines chez ces souris, codées par les gènes dits modificateurs. Notre hypothèse tourne autour de l'idée que la desmine pourrait servir de gène modificateur, puisque cette protéine est augmentée significativement dans le muscle squelettique, et pourrait donc contribuer au phénotype léger retrouvé chez ces souris.Pour explorer le rôle de la desmine chez les souris mdx, nous avons créé des souris double knock-out (dKO) (mdx: Des-/-) en croisant des souris déficientes en desmine avec des souris mdx. Nos résultats obtenus ont démontré une augmentation significative de la concentration de la protéine desmine dans les cardiomyocytes des souris mdx par rapport aux souris contrôles. Cette augmentation de desmine se présente sous une forme insoluble, avec des profils de phosphorylation et d'O-GlcNAcylation distincts entre ces deux groupes. De plus, calpaïne 1, une protéine clé dans la dégradation des filaments, y compris ceux de desmine, est réduite chez les souris mdx par rapport aux souris contrôles. Par ailleurs, αB-cristalline, protéine chaperonne de la desmine, est augmentée chez les souris mdx. Ces résultats semblent donc démontrer une stabilisation des filaments de desmine chez ces souris. Nous avons ensuite examiné le phénotype des souris dKO, révélant une aggravation des caractéristiques dystrophiques, entraînant de graves complications cardiaques, notamment une diminution des fractions d'éjection et de raccourcissement, accompagnées d'une augmentation substantielle de la fibrose. Il est important de noter que ces conditions ont entraîné une mortalité précoce, les souris succombant dès l'âge de 3 mois. Nous avons également examiné la morphologie des cardiomyocytes par microscopie électronique. Nos résultats ont dévoilé un décollement entre cardiomyocytes auniveau du disque intercalé (ID) chez les souris dKO, contrairement à des altérations mineures chez les souris mdx. Sur la base de nos résultats, nous concluons que la desmine devrait être considérée comme un nouveau gène modificateur dans la DMD et pourrait constituer une cible thérapeutique pour cette maladie<br>Duchenne muscular dystrophy (DMD) is a rare genetic disorder affecting skeletal and cardiac muscles, resulting from a mutation in the dystrophin gene, an essential muscle protein. The mdx mouse is widely used as a research model for DMD. However, the severity of the disease in mice is significantly milder than in humans. This discrepancy could potentially be attributed to the increased expression of various proteins in these mice, encoded by so-called modifier genes. Our hypothesis revolves around the idea that desmin could serve as a modifier gene, as this protein is significantly increased in skeletal muscle, and could therefore contribute to the mild phenotype found in these mice.To explore the role of desmin in mdx mice, we created double knock-out (dKO) mice (mdx: Des-/-) by crossing desmin-deficient mice with mdx mice. Our findings demonstrated a significant increase in the concentration of the desmin protein in cardiomyocytes of mdx mice compared to control mice. This increase in desmin is present in an insoluble form, with distinct phosphorylation and O-GlcNAcylation profiles between the two groups. Additionally, calpain 1, a key protein in the degradation of filaments, including those of desmin, is reduced in mdx mice compared to control mice. Furthermore, αB-crystallin, a desmin chaperone protein, is increased in mdx mice. These results seem to demonstrate a stabilization of desmin filaments in these mice.We then examined the phenotype of dKO mice, revealing an exacerbation of dystrophic characteristics, leading to severe cardiac complications, including a decrease in ejection and shortening fractions, accompanied by a substantial increase in fibrosis. Notably, these conditions resulted in early mortality, with mice succumbing as early as 3 months of age. We also examined cardiomyocyte morphology using electron microscopy. Our results revealed detachment between cardiomyocytes at the intercalated disc (ID) in dKO mice, unlike minor alterations in mdx mice. Based on our findings, we conclude that desmin should be considered a new modifier gene in DMD and could constitute a therapeutic target for this disease
7
Leewe, Hanne. ""Man lernt ja immer, wenn man sich nicht verschließt." : Lehrerinnen des Unterrichtsfaches "Lebensgestaltung - Ethik - Religionskunde" im interkulturellen Lernprozess: wie lehren sie Religion? /." Münster ;Hamburg [u.a.] : Lit, 2000. http://www.gbv.de/dms/bs/toc/310245966.pdf.
Full text
8
Baier, Konrad F. "In der Ferne sieht man die Demokraten : das Fernsehen in der Ära Adenauers und die Entwicklung der politischen Kultur /." Saarbrücken : VDM, Müller, 2007. http://www.gbv.de/dms/sub-hamburg/531994236.pdf.
Full text
9
Foraboschi, Paola Angelica. "Die ethnologischen Exzerpthefte von Karl Marx und die Geschichtsschreibung des 19. Jahrhunderts : eine Debatte ueber die Entstehung des Staates /." [Milano] : CUEM, 2000. http://www.gbv.de/dms/sub-hamburg/360435084.pdf.
Full text
10
Demoule, Alexandre. "Implication du diaphragme murin dans la genèse d'une réponse inflammatoire au cours des états septiques et dans un modèle de dystrophie musculaire." Paris 6, 2006. http://www.theses.fr/2006PA066356.
Full textBooks on the topic "Deo Max (DM7)"
1
Fischer, Hans, and Tilman Sauer, eds. Exkursionen in die Geschichte der Mathematik und ihres Unterrichts. WTM-Verlag Münster, 2021. http://dx.doi.org/10.37626/ga9783959871860.0.
Full textAbstract:
Mathematikgeschichte verbindet Mathematik, Naturwissenschaften und Geisteswissenschaften. Die Entwicklung der Mathematik ist immer auch eine Veränderung einer gesellschaftlichen Praxis, Mathematik zu betreiben und diese durch stabile Formen wie Institutionen, mathematische Werkzeuge und mathematische Sprache zu etablieren. Besonders die jüngere Geschichte der Vermittlung von Mathematik in Schule und Universität baut weitere Brücken zu Themen, die in der Psychologie, den Sozial- und Politikwissenschaften angesiedelt sind. Die integrative Sicht auf Geschichte der Mathematik prägt die gemeinsamen, im zweijährigen Turnus stattfindenden Tagungen der Fachsektion Geschichte der Mathematik der DMV und des Arbeitskreises Mathematikgeschichte und Unterricht der GDM. Dieser Tagungsband zur Mainzer Tagung, welche vom 29. Mai bis 2. Juni 2019 im Erbacher Hof stattfand, zeigt den fachübergreifenden und durch Perspektivenvielfalt geprägten Charakter dieser Tagungsreihe. Das gemeinsame Anliegen der Teilnehmerinnen und Teilnehmer, die Vorstellungen von einer oft als unveränderlich und fertig wahrgenommenen Wissenschaft Mathematik zu bereichern und zu erweitern, wird in dem vorliegenden Band auf mannigfaltige Art verwirklicht.
2
Juri Moran, Joulia Marianita, Paulina Elizabeth Durán Mora, Estefania Vanessa Arauz Andrade, et al. Ginecología Obstetricia: Patologías durante el embarazo. Mawil Publicaciones de Ecuador, 2019, 2020. http://dx.doi.org/10.26820/978-9942-826-07-7.
Full textAbstract:
En Medicina, el área de aplicación de Ginecología, la ciencia de la mujer condensa el estudio de las enfermedades frecuentes y graves, el diagnóstico, detección de los factores de riesgo y establecer mecanismos de prevención, prescribir los tratamientos médicos y quirúrgicos de las enfermedades del sis- tema reproductor femenino, entiéndase, todo lo relacionado con la vagina, las mamas, el útero y los ovarios. Durante el siglo XX, motivado por el crecimiento acelerado del conocimien- to científico y médico, se acrecienta la toma de conciencia del rol que le co- rresponde desempeñar a la medicina en el sector de la salud y la protección de la mujer embarazada. Los problemas del trato genital femenino cuando se asumen como responsabilidad de los ginecólogos, quienes incluyeron dentro del proceso de auscultación, diagnóstico y tratamiento aspectos fisiológicos y endocrinos. Las barreras de la formación académica se fueron difuminando y los ginecó- logos y obstetras comenzaron a estrechar su campo laboral y como resultante se constituyó la Ginecobstetricia. En el marco de estas reflexiones, surge la idea de la presentación de un tex- to titulado Ginecología – Obstetricia, mediante el cual se pretende hacer una contribución real a nivel teórico que permita apoyar a profesionales y estu- diantes en el área de salud humana, básicamente en algunas de las patologías o complicaciones médicas asociadas al embarazo, y tratadas por la especialidad obstétrica, así mismo, se abordan dos temas (1 y 2) de conocimiento general. Cabe indicar que el texto no pretende abordar la vasta información o literatura que sobre los temas se han tratado. El libro ha sido estructurado bajo el perfil de diez (10) temas que discurren estrictamente sobre contenidos específicos, a sa- ber: 1. El parto y sus fases, 2. Pruebas de Bienestar Fetal, 3. Amenaza de Parto Pretérmino, 4. Ruptura Prematura de Membranas, 5. Amenaza de aborto, 6. Desprendimiento de placenta, 7. Infecciones de vías urinarias en embarazadas, 8. Diabetes Gestacional, 9. Hipertension en las embarazadas y 10. Preeclamp- sia y eclampsia En el primer tema, el Parto y sus fases, se precisan diferentes nociones sobre 26 GINECOLOGIA - OBSTETRICIA el proceso y el resultado de parir (dar a luz). A lo largo de la historia ha evolu- cionado el conocimiento de este tema dando como resultado una terminología precisa sobre los diferentes tipos de parto: parto natural, parto normal, parto ins- trumental, parto pretérmino, parto humanizado, etc. Estas nociones obedecen a determinadas circunstancias específicas que lo circunscribe como el uso o no de instrumentos que ayuden al nacimiento de un feto. De manera general, el parto marca el final del embarazo y el nacimiento de la criatura que se engendraba en el útero de la madre. Este proceso por el que la mujer o la hembra de una especie vivípara expulsa el feto y la placenta al final de la gestación consta de tres fases: la fase de dilatación, la de expulsión y la placentaria o de alumbramiento. En el segundo tema titulado Pruebas de Bienestar Fetal, se destaca el desa- rrollo de diferentes pruebas para el control del bienestar fetal. Éstas constitu- yen las técnicas aplicadas a las madres que permiten predecir el posible riesgo fetal o hacer un pronóstico del estado actual del feto, es decir, que tratan de conseguir a través de una valoración del feto de forma sistemática, la identifi- cación de aquellos que están en peligro dentro del útero materno, para así to- mar las medidas apropiadas y prevenir un daño irreversible. Se abordan en este contexto las indicaciones y los métodos (clínicos, biofísicos y bioquímicos más utilizados para el control de bienestar fetal. En el tema tres (3) denominado Amenaza de Parto Pretérmino, el trabajo se centra, en el desarrollo de los siguientes ítems. La Definición de Parto Pretérmi- no, la Definición de amenaza de Parto Pretérmino, la Evaluación del riesgo, la etiología, la Clínica de la Amenaza de Parto Pretérmino, el Diagnóstico precoz de la Amenaza de Parto Pretérmino, la Evaluación de gestantes que acuden a emergencia por signos y síntomas de Amenaza de Parto Pretérmino y el trata- miento. El trabajo parte de la definición de Parto Pretérmino entendido como aquel que ocurre después de la semana 23 y antes de la semana 37 de gestación, para posteriormente, tratar lo relativo a la Amenaza de Parto Pretérmino (APP) definido como el proceso clínico sintomático (Aparición de dinámica uterina regular acompañado de modificaciones cervicales) que puede conducir a un parto pretérmino. Su etiología es compleja y multifactorial, en la que pueden intervenir de forma simultánea factores inflamatorios, isquémicos, inmunológi- cos, mecánicos y hormonales. 27 GINECOLOGIA - OBSTETRICIA Por otro parte, el tema cuatro (4) expone la Ruptura Prematura de Membra- nas, la cual constituye una complicación usual en la práctica obstétrica, esta puede aumentar la incidencia en la morbilidad y mortalidad materna – fetal. Múltiples estudios se están llevando a cabo para poder dilucidar completamente su fisiopatología, lo cual se hace cada vez más necesario para poder aplicar estos conceptos en la práctica clínica, la evidencia actual indica que la Ruptura Prematura de Membrana es un proceso que puede ser afectado por factores: bioquímicos, fisiológicos, patológicos y ambientales. El capítulo cinco (5) comprende la temática sobre la Amenaza de aborto. (AA) que es la complicación más común durante el embarazo, se define como el sangrado transvaginal antes de las 20 semanas de gestación (SDG) gestación o con un feto menor de 500g, con o sin contracciones uterinas, sin dilatación cervical y sin expulsión de productos de la concepción”. Es decir, se presenta hemorragia de origen intrauterino antes de la vigésima semana completa de ges- tación, con o sin contracciones uterinas, sin dilatación cervical y sin expulsión de los productos de la concepción. Los síntomas abarcan amenorrea secundaria, presencia de vitalidad fetal y cólica abdominales con o sin sangrado vaginal entre otros. Para el diagnóstico se puede hacer una ecografía abdominal o va- ginal, examen pélvico y de laboratorio. En un principio el tratamiento consiste en recomendar reposo en cama y reposo pélvico. La identificación de factores de riesgo, el Ultrasonido obstétrico y la medición de marcadores bioquímicos son de gran importancia para realizar un diagnóstico y establecer un pronóstico oportuno. Estos aspectos y otros relacionados con el tema como son: la clínica, el protocolo a seguir, el tratamiento y la prevención, son tratados en este capí- tulo. El tema Desprendimiento de placenta es desarrollado a lo largo del tema seis (6). Su contenido aborda los aspectos importes como los factores de riesgo, etiología, síntomas y signos, diagnóstico y tratamiento de esta complicación cuyo proceso se caracteriza por el desprendimiento total o parcial, antes del parto, de una placenta que esta insertada en su sitio normal. Este hecho que puede traer grandes consecuencias para el feto y para la madre, puede ocurrir en cualquier momento del embarazo. Los desprendimientos producidos antes de las 20 semanas, por su evolución, deberán ser tratados como abortos. Los que tienen lugar después de la semana 20 de gestación y antes del alumbramiento constituyen el cuadro conocido como desprendimiento prematuro de la placenta normalmente insertada. (abrptio plantae o accidente de Baudelocque). El pro- ceso ha tenido una variedad de denominaciones a lo largo del tiempo y son consecuencia de la diversidad de cuadros clínicos que pueden producirse, sien- do las más empleadas en la actualidad: abruptio placentae, ablatio placentae, desprendimiento prematuro de placenta normalmente inserta (DPPNI), junto con el término abreviado desprendimiento prematuro de placenta (DPP). Para hablar de otra importante complicación que aqueja a la gestante y su bebe por nacer se expone en el tema (7) relacionado con las Infecciones de vías urinarias en embarazadas. Los particulares cambios morfológicos y funcio- nales que se producen en el tracto urinario de la gestante hacen que la infec- ción del tracto urinario (ITU) sea la segunda patología médica más frecuente del embarazo, por detrás de la anemia. Las 3 entidades de mayor repercusión son: Bacteriuria asintomática (BA) (2-11%), cuya detección y tratamiento son fundamentales durante la gestación, pues se asocia a prematuridad, bajo peso y elevado riesgo de progresión a pielonefritis aguda (PA) y sepsis; la Cistitis aguda (CA) (1,5%) y la Pielonefritis aguda (1-2%), principal causa de ingreso no obstétrico en la gestante, que en el 10 al 20% de los casos supone alguna complicación grave que pone en riesgo la vida materna y la fetal. La Diabetes Gestacional se ubica y desarrolla en el tema ocho (8). Este tipo de diabetes que aparece o se diagnostica durante el embarazo ha aumentado su prevalencia y cobrado gran relevancia epidemiológica en los últimos años. La Diabetes Gestacional (DG) o Diabetes Mellitius Gestacional (DMG) se carac- teriza por una secreción de insulina insuficiente para compensar la resistencia a la hormona, propia del embarazo. Después del parto, los niveles de glucosa sanguínea suelen normalizarse; sin embargo, algunas mujeres desarrollan DM tipo 2 y se asocia con complicaciones graves en la madre y el hijo, incluso años después del nacimiento. La Hipertensión en las Embarazadas, tema tan tratado y controvertido en los últimos años por su significación a nivel de que es la complicación médica 29 GINECOLOGIA - OBSTETRICIA más frecuente de la gestación y ocurre según estudios comprobados en el 7% a 10% de los embarazos y constituye una causa importante de morbimortalidad materna y perinatal. De manera clásica, la HTA en el embarazo ha sido definida como el incremento, durante la gestación, de la presión arterial sistólica (PAS) en 30 mmHg o más y/o la presión arterial diastólica (PAD) en 15 mmHg o más comparado con el promedio de valores previos a la 20va. semana de gestación. Cuando no se conocen valores previos, una lectura de 140/90 mmHg o mayor es considerada como anormal. El tema desarrollado abarca una visión general sobre algunos aspectos relativos a la definición y su clasificación, los factores predisponentes, sintomatología, diagnóstico, tratamiento, etc. Por último, el tema 10 aborda dos alteraciones íntimamente ligadas a la hi- pertensión arterial en el embarazo: la preeclampsia y la eclampsia. Éstas son en ocasiones tratadas como componentes de un mismo síndrome ya que la pree- clampsia es la hipertensión de reciente comienzo con proteinuria después de las 20 semanas de gestación y la eclampsia es la presencia de convulsiones genera- lizadas inexplicables en pacientes con preeclampsia.
Book chapters on the topic "Deo Max (DM7)"
1
Meyer, Andrea. "4.2 Die Beschlüsse der ersten DMB-Jahrestagung in Würzburg im Mai 1918 - ein Kompromiss." In Kämpfe um die Professionalisierung des Museums. transcript Verlag, 2021. http://dx.doi.org/10.14361/9783839458334-016.
Full text
2
Willems, W., J. Weber, O. E. Henmann, et al. "DME/OMEi - Nachhaltige Kraftstoffe fur den selbstzündenden Verbrennungsmotor für Pkw und Nutzfahrzeuganwendungen /DME/OME1 - Sustainable Fuels for Compression Ignition Engines for Passenger Car and He..." In 40. Internationales Wiener Motorensymposium 15.-17. Mai 2019. VDI Verlag, 2019. http://dx.doi.org/10.51202/9783186811127-ii-103.
Full text
3
"4.2 Die Beschlüsse der ersten DMB-Jahrestagung in Würzburg im Mai 1918 – ein Kompromiss." In Kämpfe um die Professionalisierung des Museums. transcript Verlag, 2021. http://dx.doi.org/10.1515/9783839458334-016.
Full text
4
Hamoud, Hesham. "Non-GCs Drug-Induced Osteoporosis." In Biomechanical and Mechanobiological Analysis of Bone Mineral Density [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108296.
Full textAbstract:
Medications that cause osteoporosis are numerous and common. While helping to correct one problem, they may be putting you at greater risk of having osteoporosis. A variety of drugs may cause bone loss by lowering sex steroid levels (e.g., aromatase inhibitors used in breast cancer and GnRH agonists used in prostate cancer), interfering with vitamin D levels (liver-inducing antiepileptic drugs), or directly affecting bone cells (chemotherapy, phenytoin, or thiazolidinediones) which divert mesenchymal stem cells from osteoblastogenesis to adipocytogenesis, consequently, an imbalance occurs between bone formation and resorption, as well as between soft organic matrix and hard inorganic matrix. Besides effects on the mineralized matrix, interactions with collagen and other nonmineralized matrix components can decrease bone biomechanical competence without affecting bone mineral density (BMD). Here is a quick narrative for a number of disease medications that can cause osteoporosis if taken for long periods without a preventive program of minerals and vitamins. Rheumatoid arthritis, inflammatory bowel disease, asthma, acid reflux, thyroid dysfunctions, seizures, endometriosis, aromatase inhibitors, hypertension, contraceptive Depo-Provera, antidepressant (SSRIs, SNRIs), glitazones for type 2 DM treatment.
5
Feather, Leonard, and Ira Gitler. "h." In The Biographical Encyclopedia of Jazz. Oxford University PressNew York, NY, 1999. http://dx.doi.org/10.1093/oso/9780195074185.003.0008.
Full textAbstract:
Abstract Hackett, bobby (robert leo), tpt, crnt, gtr; b. Providence, RI, 1/31/15; d. Chatham, MA, 6/7/76. Son of a blacksmith, sixth of nine children. Son, Ernie Hackett, active as jazz dmr. in ’70s. Start. on uke., he left school at 14 and began pl. gtr., bjo., vln., w. local bands and in Syracuse. In 1933, pl. mainly crnt., was part of trio w. Pee Wee Russell and Teddy Roy, perf. in various Boston and Providence clubs. In ’36 took over lead. of Ted Marsh’s band at the Theatrical Club, Boston, w. Brad Gowans writing arrs. Though he was mainly infl. by Armstrong dur. this period, he eventually became more closely identified w. the lyrical style of Bix Beiderbecke. Went to NYC in ’37, pl. gtr. w. Joe Marsala, doubling on crnt; own band at Nick’s ’38–9; own bb at the Famous Door and on tour ’39; disbanded and join. Horace Heidt ’39–40; w. Glenn Miller on gtr., occ. crnt. ’41–2. In ’43, NBC staff; also tour. w. Katherine Dunham dancers ’43; w. Glen Gray ’44–6. ABC staff for several yrs. from ’46; frequent apps. at Nick’s; tour. East Coast w. own band early ’50s. In ’53–5 he earned wide recognition through a series of mood albums on Capitol led by Jackie Gleason, w. whom he also app. in person. TV shows w. Martha Wright; other broadcasts. Fr. ’56 to ’58, led a sxt. at the Henry Hudson Hotel and for brief tours and jazz fests., then led qt. in NYC clubs and on tours. Pl. w. B. Goodman ’62–3, incl. Mex.; worked frequently w. Tony Bennett in mid ’60s. Moved to Cape Cod ’69, where he was often feat. at Dunfey’s. Pl. w. Vic Dickenson in NYC and US tour ’70; in ’70s also feat. guest w. WGJB; tour. Eng. ’74; apps. at Michael’s Pub ’75. Hospitalized for two weeks in May ’76, he perf. on June 4 after his release, then died of a heart attack three days later. From his first days in NYC, Hackett was an important force in jazz. While he made his name as a crntst. and tptr., he remained a proficient gtrst. His melodic style has been praised by musicians of every description, and his beautifully burnished sound easily complemented a variety of jazz idioms. Fests: NJF w. Dickenson ’70; many apps. at NJF-NY; Colo. JP. TV: Just Jazz w. Dickenson; PBS ’71. Recs. as lead: Epic; Cap. CDs: Project 3; Jazz.; Hackett-Dickenson (Chiaro.); as lead. and sideman in The Commodore Story (Comm.); w. Armstrong; Miller; Teagarden (BB); Goodman; B. Holiday (Col.); Condon (Dec.; Stash; Sav; Jazz.; Comm.); Pee Wee Russell (Comm.); T. Wilson (Hep); Teddy Grace (Timel.); Gleason (Cap.).
6
Damião, Nathalie de Paula, Lucas Moura Araújo, Ana Clara Marcondes Plastina, Denise Siqueira de Carvalho, and Fabian Calixto Fraiz. "CONTINUITY OF CARE IN PATIENTS WITH SYSTEMIC ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS IN PRIMARY HEALTH CARE IN THE MUNICIPALITY OF PINHAIS DURING THE COVID-19 PANDEMIC." In Contribuições da Saúde Coletiva para as Redes de Atenção - Volume 2. Editora Científica Digital, 2024. https://doi.org/10.37885/241218464.
Full textAbstract:
On December 31, 2019 in Wuhan, China, a coronavirus, called SARS-CoV-2, was identified as causing a disease that was called COVID-19. On March 11, 2020, the World Health Organization (WHO) declared that COVID-19 was a pandemic, when it was then considered an international emergency. The first case confirmed in Brazil occurred on February 26, 2020 (Lana et al., 2020). Patients with chronic diseases unrelated to COVID-19, also called "invisible patients'', were directly affected by a collapsed and overcrowded health system of patients with COVID-19 and its sequelae, mainly due to difficulties related to the need for continuity of care that is required by their pathologies (Mendes, 2020). Chronic diseases are also considered epidemics, and Chronic Non-Communicable Diseases (NCDs) are a serious public health problem worldwide (WHO, 2005). According to the WHO, Systemic Arterial Hypertension (SAH) and Diabetes Mellitus (DM) are among these chronic diseases, having as a common characteristic a continuous and constant demand of health services by their patients, with the aim of maintaining the control of comorbidity, acquisition of medicines for this purpose and periodic examination (Brasil, 2008). It is estimated that around 75% of the Brazilian population monitors their health through the Unified Health System – SUS (Khera et al., 2020). However COVID-19 impacted the population in general, including those with cardiovascular diseases (Coma et al., 2020), with changes in access to health services and life habits caused by social distancing, stress, and anxiety caused by the pandemic. The decrease in the follow-up, control and screening of Primary Health Care (PHC) patients, due to the COVID-19 pandemic, was observed in a study conducted in Catalonia, an autonomous community of Spain. Consequently, there was an increase in glycated hemoglobin levels in patients with type 2 diabetes mellitus (T2DM), proportional to the lockdown time (Baratieri; Marcon, 2011). Brazil constantly sought ways to improve its health care model, and in 1994, the Family Health Program was created. Its creation was focused on family and team, which is a significant part of PHC, and aimed at continuous patient care. PHC has specific characteristics by definition. They are accessibility, longitudinality, comprehensiveness, and coordination of care (Sarti et al., 2020). Due to its fundamental role in the pandemic and strategic role in the post-pandemic scenario, it was essential to understand the territory and its inhabitants, establish a link between the health team and the user of the system, and incorporate assistance (Lana et al., 2021). Some health teams attempted to mitigate the negative effects of the pandemic on patients with NCDs by using phone calls, instant messaging on cell phones and other technological devices. Although an effort with positive results can be helpful, it may not be suitable for patients who do not have the knowledge or access to the technology required for this type of care. It is possible that some patients were afraid to report their symptoms to their healthcare staff because they thought their complaints were less important than concerns related to COVID-19 (Coma et al., 2020). This study aims to analyze how the COVID-19 pandemic affects the continuity of primary healthcare in Pinhais, Paraná, among adult patients over 18 years of age who have SAH and T2DM simultaneously.
Conference papers on the topic "Deo Max (DM7)"
1
Nogueira, Vitória Ribeiro, Beatriz Lisboa Campos, Gustavo Nakamura Morais, Maria Eduarda Cantelmo de Mesquita, Maria Fernanda de Jesus Alves, and Douglas Roberto Guimarães Silva. "MANEJO DAS EXACERBAÇÕES AGUDAS DA DPOC EM EMERGÊNCIAS HOSPITALARES." In Anais do I Congresso Brasileiro de Urgência e Emergência. Even3, 2025. https://doi.org/10.29327/1484146.1-4.
Full textAbstract:
A doença pulmonar obstrutiva crônica (DPOC) é uma condição progressiva e irreversível que afeta milhões de pessoas globalmente, sendo causada principalmente pela exposição a fatores como tabagismo, poluição ambiental e predisposição genética. As exacerbações agudas da DPOC, frequentemente desencadeadas por infecções respiratórias ou fatores ambientais, podem levar ao comprometimento funcional pulmonar, acelerando o declínio da função respiratória, se manifestando com sinais como dispneia, tosse, sibilos, aumento e alteração da produção de escarro, necessitando de atendimento imediato, sendo assim um dos maiores desafios no tratamento da doença. Objetivo: Analisar o papel de estratégias e tratamentos adjuvantes no manejo das exacerbações agudas da DPOC no contexto de atendimento de emergências hospitalares. Materiais e métodos: Trata-se de uma revisão de literatura com busca realizada na base de dados PubMed utilizando os termos Pulmonary Disease Chronic Obstructive AND Emergency Service AND Acute Exacerbations, abrangendo artigos publicados de 2014 a 2024. Com essa estratégia de busca foram encontrados 368 artigos. Após o emprego dos filtros: texto completo, ensaios clínicos, meta-análises, ensaio controlado randomizado, análise, revisões sistemáticas e a triagem realizada pelo Rayyan foram selecionados 6 artigos para leitura integral. No desenvolvimento, um dos artigos foi excluído, pois o artigo possui erro de programação e outros erros que afetam o resultado. Visto isso, ele não apresentou resultados nem informações significativas para a revisão. Resultados e discussão: A análise evidencia múltiplas estratégias clínicas e seus respectivos impactos nos desfechos dos pacientes. Os resultados reforçam a complexidade da avaliação e manejo, destacando tanto avanços quanto limitações no uso de diferentes abordagens diagnósticas e terapêuticas. Um dos estudos relata uma análise comparativa entre gases arteriais (ABG) e venosos (VBG) que revelou diferenças importantes em parâmetros como PaCO2 (DM = 5,32; IC 95%: 3,32–7,33; P < 0, 00001) e HCO3 (MS = 1,05; IC 95%: 0,27–1,83; P = 0,009), mas menor discrepância nos valores de pH (MS = -0,00; IC 95%: -0,05–0,04; P = 0,85). Apesar da alta heterogeneidade entre os estudos (I2 > 50%), os achados indicam que a VBG pode ser utilizada como método complementar quando a coleta arterial é contraindicada, embora não substitua completamente a ABG, especialmente para monitoramento preciso de PaCO2. Em foco de intervenções terapêuticas, a administração intravenosa de sulfato de magnésio foi associada a melhorias nos valores de FEV1 e SpO2, bem como a reduções na frequência respiratória e na dispneia. No entanto, essas melhorias não foram estatisticamente significativas. O sulfato de magnésio potencializa os efeitos dos broncodilatadores beta-agonistas, indicando um papel complementar em contextos específicos. Ademais, o uso de terbutalina, isolada ou combinada com outros broncodilatadores, não mostrou diferenças significativas em estudos como administração hospitalar (59,8% vs. 65,2%; P = 0,39), intubação endotraqueal (7,7% vs. 8). 7%; P = 0,78), ou duração da internação (5,5 ± 2,4 dias vs. 6,5 ± 2,1 dias; P = 0,11). Para manejo das exacerbações agudas a implementação de protocolos de transição hospitalar torna significativa a redução das readmissões em 7 dias (RR: 0,17; IC 95%: 0,07–0,35) e 30 dias (RR: 0,74; IC 95%: 0,60–0,91). Contudo, houve um aumento no tempo de internação (RR: 1,07; IC 95%: 1,00–1,15) e maior risco de visitas ao pronto-socorro em 30 dias (RR: 1,76; IC 95%: 1,53–2,02). Considerações Finais: Os dados indicam que o manejo de exacerbações agudas da doença pulmonar obstrutiva crônica (EADPOC) em emergências representa um desafio latente na prática médica que deve equilibrar a eficácia das intervenções com sua aplicabilidade clínica. Esta revisão buscou avaliar a efetividade clínica de diferentes abordagens e intervenções, analisando seus benefícios e limitações para subsidiar práticas mais assertivas no manejo dessa condição. Embora a VBG mostre utilidade em contextos específicos, sua precisão limitada restringe seu uso isolado. Intervenções farmacológicas, como sulfato de magnésio e terbutalina, apresentam benefícios potenciais, mas necessitam de estudos adicionais para validação. Os protocolos de transição hospitalar se mostraram eficazes para reduzir readmissões precoces, mas o aumento do tempo de internação e as visitas subsequentes ao pronto-socorro, provavelmente devido ao maior entendimento dos pacientes sobre seus sintomas, evidenciam desafios na continuidade do cuidado. Por fim, o manejo de EADPOC deve priorizar intervenções baseadas em evidências, combinadas com estratégias organizacionais bem estruturadas, para otimizar os desfechos clínicos e a qualidade de vida dos pacientes. Dessa forma, verifica-se que os desfechos dos estudos analisados ainda não proporcionaram medidas plenamente aplicáveis na prática clínica, denotando a imprescindibilidade de ~ 71 ~ novos estudos e investigações mais aprofundadas para abordar lacunas, como a validação prospectiva de abordagens e a padronização de protocolos clínicos.
2
"PV-003 - SISTEMA ENDOCANNABINOIDE EN DEPRESIÓN DUAL." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.pv003.
Full textAbstract:
Uno de los factores cruciales para el abordaje clínico de la comorbilidad entre depresión mayor (DM) y trastorno por consumo de alcohol (AUD) es determinar si la DM es primaria (DM-P) o bien inducida por consumo (DM-I), tanto por sus implicaciones pronósticas como para la estrategia terapéutica a seguir. Las investigaciones más recientes muestran que el riesgo de recaídas en el consumo de sustancias es aún mayor en pacientes diagnosticados de DM-I que de DMP, y se ha observado que algunos de los sujetos con DM-I, en seguimientos longitudinales son diagnosticados de DM-P. Así mismo, hay indicios de diferencias de respuesta a los fármacos antidepresivos según el tipo de depresión Como potenciales biomarcadores se ha postulado el sistema endocannabinoide (eCB), debido a la creciente evidencia científica que lo vincula a la fisiopatología de la DM. 1. Objetivos Realizar una revisión de la literatura científica para analizar el papel del sistema endocannabinoide en la depresión y el trastorno por consumo de alcohol. 2. Material y métodos Se realizará una revisión de la base de datos Pubmed. Se analizarán estudios en depresión y en trastorno por consumo de alcohol. Se presentarán los datos de manera narrativa y gráfica. Se analizará el potencial papel de endocannabinoides periféricos como biomarcadores para el diagnóstico diferencial entre depresión mayor primaria e inducida por alcohol. 3. Resultados y conclusiones. 14 artículos escogidos para revisión. Pendiente de análisis de resultados. A partir de los mismos se elaborará un plan de investigación empírico en el Hospital del Mar (Barcelona).
3
Nogueira, Fábio Dias, Ana Klara Rodrigues Alves, Barbara Beatriz Lira da Silva, et al. "The relationship of diabetes mellitus with Alzheimer’s disease: a literature review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.280.
Full textAbstract:
Introduction: Alzheimer’s disease (AD) is closely related to diabetes mellitus (DM), and AD is also considered to be type 3 diabetes (T3D). Glycogen synthase kinase-3β (GSK-3β) may be the potential link between DM and AD. GSK-3β is one of the main factors that lead to insulin deficiency and insulin resistance, and insulin resistance is a characteristic of the development of DM. In AD, GSK-3β plays an important role in hyperphosphorylation of the tau protein (tau) associated with microtubules, which is one of the pathological features in AD. Objective: To analyze DM as a factor for the development of AD. METHODOLOGY: This is an integrative review of the literature, which is a construction of a comprehensive analysis of the literature with pre-defined steps, carried out through PubMed, 1.501 articles were found, of which 10 were selected, through the simultaneous crossing between the descriptors “Diabetes mellitus”, “Alzheimer “. Articles written in Portuguese and English published between 2016 and 2021 were inserted. Results: DM associated with insulin resistance affects psychomotor efficiency, attention, learning memory, mental flexibility, speed and executive function of the brain, thus being an independent risk factor for cognitive impairment and damage to the central nervous system, hyperglycemia, which can cause increased oxidative stress leading to progressive functional and structural abnormalities in the brain. Conclusion:The risk of dementia in patients with DM is higher than in nondiabetic patients and it is also well known that DM2 / insulin resistance is involved in AD.
4
Moresco, RN, E. Tatsch, and JAM Carvalho. "LIPOCALINA ASSOCIADA À GELATINASE NEUTROFÍLICA (NGAL) URINÁRIA E SUA ASSOCIAÇÃO COM O CONTROLE GLICÊMICO EM PACIENTES PORTADORES DE DIABETES MELLITUS TIPO 2." In Resumos do 55º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s2.8151.
Full textAbstract:
Objetivo: A lipocalina associada à gelatinase neutrofílica (NGAL) é uma proteína expressa em células renais em resposta a estímulos como inflamação e isquemia. Assim, o objetivo do estudo foi investigar se o NGAL urinário, biomarcador de dano tubular renal, está associado ao controle glicêmico em pacientes com diabetes mellitus tipo 2 (DM2). Método: Foram investigados 117 pacientes com DM2, com idade de 59,2 ± 12,9 anos. HbA1c, creatinina, taxa de filtração glomerular estimada (TFG), albumina urinária e NGAL urinário foram avaliados. As concentrações de HbA1c foram obtidas por cromatografia líquida de alta eficiência no analisador D10® (Bio-Rad). Creatinina e albumina urinária foram mensuradas na plataforma Dimension RxL Max® (Siemens) e NGAL urinária, por Elisa (R&D Systems®). A TFG foi estimada pela equação CKD-EPI. Os pacientes foram organizados em dois grupos com base no valor meta da HbA1c recomendada pela Sociedade Brasileira de Diabetes (SBD), sendo classificados em HbA1c < 7% e HbA1c ≥ 7%. Os resultados foram analisados estatisticamente por meio do teste t de Student ou Mann-Whitney. Conclusão: As concentrações de HbA1c foram 5,9 ± 0,5% e 9,1 ± 1,7% (p < 0,001). Pacientes com HbA1c ≥ 7% eram portadores de DM2 há mais tempo em comparação àqueles com HbA1c < 7% (p = 0,023). Não houve diferença na TFG entre os grupos. Já as concentrações urinárias de albumina e de NGAL foram mais elevadas nos pacientes com HbA1c ≥ 7%. Para albumina urinária, os valores encontrados nos grupos HbA1c < 7% e HbA1c ≥ 7% foram, respectivamente, 7 (4,6-10,8) mg/g cre e 12,6 (5,8-23,1) mg/g cre (p = 0,021); para NGAL foram 35 (28-44) ng/ml e 45 (30-62) ng/ml (p = 0,035). Esses achados indicam a presença de alterações renais a nível glomerular e tubular nos pacientes portadores de DM2 que apresentaram valores de HbA1c ≥ 7%, reforçando a importância do controle glicêmico como estratégia fundamental para a prevenção do desenvolvimento de doenças renais em pacientes com DM2.
5
Rossato, BG, LLS Santos, E. Tatsch, JAM Carvalho, and RN Moresco. "ASSOCIAÇÃO ENTRE O ÍNDICE TYG, UM MARCADOR DE RESISTÊNCIA À INSULINA, COM O CONTROLE GLICÊMICO EM PACIENTES COM DIABETES MELLITUS TIPO 2." In Resumos do 55º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s2.8143.
Full textAbstract:
Objetivo: A resistência à insulina é uma das principais características do diabetes mellitus tipo 2 (DM2). Dessa forma, marcadores para a sua triagem são fundamentais. O índice TyG, ferramenta usada para avaliar resistência à insulina, é um método simples e apresenta precisão, indicando um bom substituto na pratica clínica. Assim, o objetivo deste estudo é investigar a associação entre o índice TyG e o controle glicêmico em pacientes portadores de DM2. Método: Foram estudados 117 pacientes de ambos os sexos com DM2 e idade de 59,2 ± 12,9 anos. A avaliação laboratorial incluiu a análise da glicemia de jejum, HbA1c, triglicerídeos e índice TyG. A HbA1c foi quantificada por cromatografia líquida de alta eficiência no analisador D10® (Bio-Rad). Glicose e triglicerídeos foram mensurados no analisador Dimension RxL Max® (Siemens). O índice TyG foi calculado por meio da fórmula: TyG = Ln [triglicerídeos jejum (mg/dl) × glicemia jejum (mg/dl)]/2. Os pacientes foram organizados em dois grupos com base no valor meta da HbA1c recomendada pela Sociedade Brasileira de Diabetes (SBD), sendo classificados em HbA1c < 7% e HbA1c ≥ 7%. Os resultados foram analisados estatisticamente através do teste t de Student ou Mann-Whitney. Conclusão: As concentrações de HbA1c foram 5,9 ± 0,5% e 9,1 ± 1,7% (p < 0,001), enquanto os valores de glicose foram 109 (97-119) mg/dl e 160 (125-205) mg/dl (p < 0,001). Não houve diferença significativa para triglicerídeos entre os grupos [128 (101-182) versus 131 (83-185) mg/dl (p = 0,655)]. Interessantemente, pacientes com HbA1c ≥ 7% apresentaram o índice TyG maior em comparação com aqueles com HbA1c < 7% (5,08 ± 0,39 versus 4,7 ± 0,19, p < 0,001). Com base nos resultados obtidos, foi possível verificar que o índice TyG foi mais elevado nos pacientes com HbA1c ≥ 7%, indicando que existe uma associação entre a resistência insulínica avaliada por esse índice e o controle glicêmico no DM2.
6
de Oliveira, José Maria Teixeira, Anna Tereza Kulik Bertipalha, João Guilherme de Souza Ramos, and Thalya Michels Sens. "Relação entre Diabete Mellitus e Retinopatia Diabética." In 1st Seven Global Congress of Multidisciplinary Studies. Seven Congress, 2025. https://doi.org/10.56238/1stcongresssevenmultidisciplinarystudies-018.
Full textAbstract:
INTRODUÇÃO: O Diabete Mellitus (DM) é uma doença crônica com alta prevalência global, afetando milhões de pessoas. Uma das complicações mais graves é a Retinopatia Diabética (RD), que atinge 34,6% dos diabéticos mundialmente, com cerca de 10,2% dos casos levando à perda visual importante. Ademais, no Brasil, a prevalência da RD entre diabéticos tipo 2 é de 34%, enquanto 44% dos com DM tipo 1 apresentam algum grau de RD. Dessa maneira, a hiperglicemia é o principal agente para o desenvolvimento de microangiopatia e a RD é a mais específica. Além disso, estima-se que quase 100% dos pacientes com DM tipo 1 desenvolvem RD em 15 anos. O diagnóstico e tratamento precoces são essenciais para reduzir o risco de dano visual irreversível, mas o Brasil ainda carece de um programa de triagem específico para RD. Além de comprometer a qualidade de vida, as complicações do DM têm impacto econômico significativo, com estimativas indicando que a doença pode consumir de 5 a 14% das despesas de saúde do Estado. METODOLOGIA: O presente estudo realizou uma avaliação abrangente da literatura existente sobre a Relação entre Diabete Mellitus e Retinopatia Diabética. A pesquisa utilizou publicações científicas e revisões de literatura como principais fontes de informação. Essas fontes foram acessadas por meio de bases de dados renomadas, como Pubmed, Scielo, LILACS e MedLine. A busca foi realizada utilizando os descritores ”Diabetes Melitus” e "Retinopatia Diabética ". Além disso, um total de dez artigos foram selecionados dentro do período de 2014 a 2024. DISCUSSĀO: A retinopatia diabética (RD) é uma complicação microvascular mais frequentes, e altamente específica do diabetes mellitus tipo 1 e 2, podendo ser classificada em RD não proliferativa ou RD proliferativa. A apresentando alta prevalência, podendo variar conforme a região e as condições de acesso ao tratamento e ao monitoramento da doença, sua incidência é significativa entre os pacientes com diabetes tipo 1 e tipo 2, especialmente se o controle glicêmico não for adequado. A retinopatia diabética, por si só, não costuma ser a causa direta de morte. No entanto, pode levar a complicações severas como a perda de visão, que pode afetar a qualidade de vida e a capacidade de gerenciar a saúde geral do paciente. Seu diagnóstico pode ser feito por oftalmoscopia (direta e indireta), a biomicroscopia da retina sob midríase medicamentosa, estadiamento da retinopatia, documentação fotográfica (retinografia) ou mapeamento da retina. O diabetes mellitus (DM) é uma doença de grande impacto na saúde pública. O aumento de sua prevalência traz consigo o aumento da incidência da retinopatia diabética (RD), que é a complicação mais comum ocasionada pelo DM mau controlado ao longo do tempo. Dessa forma, se faz importante detectar precocemente a RD para não só evitar a progressão da doença, mas também, ter melhores resultados terapêuticos e, com isso, prevenir complicações que impactam drasticamente o bem-estar socioeconômico dos acometidos. O avanço gradual da RD pode ocasionar o edema macular diabético, a proliferação fibrovascular e a formação de novos e delicados vasos sanguíneos retinianos que podem resultar em descolamento de retina, hemorragias retinianas e diminuição da acuidade visual, resultando em complicações extremas e gravíssimas como a perda de visão central ou até mesmo, a cegueira. Detectando precocemente a RD, melhores são as chances de eficácia terapêutica e de preservar a visão do paciente. Atualmente, a fotocoagulação com laser de argônio é o tratamento mais comum utilizado, coagulando áreas retinianas especificamente afetadas. Em casos ainda mais graves, é indicada a vitrectomia. Portanto, o monitoramento clínico contínuo se faz fundamental para o manejo eficaz da retinopatia diabética, sendo crucial os controles glicêmicos e pressóricos e a permanência de acompanhamento e avaliação oftalmológica regulares a partir do momento do diagnóstico de RD, para que alterações retinianas sejam precocemente percebidas e com isso, o paciente mantenha ao máximo sua independência e funcionalidade e o sistema de saúde tenha uma economia significativa. CONCLUSÃO: O manejo da retinopatia diabética (RD) deve seguir diretrizes claras para garantir a detecção e tratamento precoces. Recomenda-se que adultos com diabetes tipo 1 (DM1) iniciem o rastreamento após cinco anos de diagnóstico, enquanto crianças e adolescentes com DM1 devem ser avaliados a partir dos 11 anos. Para aqueles com diabetes tipo 2 (DM2), o rastreamento deve ser feito no momento do diagnóstico. Exames oftalmológicos abrangentes, incluindo retinografia e biomicroscopia, são essenciais, e o uso de tecnologias como a fotografia retiniana pode facilitar o acesso ao diagnóstico. O controle rigoroso da glicemia, pressão arterial e dislipidemia é fundamental para retardar a progressão da RD. Em casos de RD moderada a grave, o encaminhamento para oftalmologistas e intervenções como fotocoagulação a laser são recomendados. A vigilância durante a gestação e o aconselhamento apropriado para gestantes com diabetes são cruciais para prevenir complicações. Em resumo, a adoção dessas recomendações é vital para preservar a visão e melhorar a qualidade de vida dos pacientes diabéticos, destacando a importância do rastreamento contínuo e do manejo adequado da retinopatia diabética.
7
Rodbard, Gabriela Ávila, Nathália Mitsue Kishi, Renata Dal-Prá Ducci, et al. "Non-motor symptoms and signs of Myotonic Dystrophy type 1." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.530.
Full textAbstract:
Introduction: Myotonic Dystrophy Type 1 (DM1) is a genetic disease that presents neuromuscular manifestations and multisystemic clinical repercussions, such as cardiac and respiratory disorders, sleep disorders and impaired swallowing, among others. It is the most common muscular dystrophy in adults. Objectives: To determine the epidemiological profile of patients with DM1 treated at the Neuromuscular Diseases Outpatient Clinic of the Complexo Hospital de Clínicas da Universidade Federal do Paraná (CHC-UFPR). Methods: A total of 27 individuals diagnosed with DM1, assisted at the Neuromuscular Diseases Outpatient Clinic of the CHC-UFPR, were evaluated between May 2021 and March 2022. For this purpose, their medical records with the clinical data were analyzed. Results: The sample consisted of 78% male subjects with mean age at onset of symptoms of 27.6 ± 10.8. The most frequent muscular manifestations were myotonia (100%), weakness of the distal muscles of the upper (96.3%) and lower (96.3%) limbs, myotonic facies (92.6%). The most common non-motor manifestations were excessive daytime sleepiness (74.1%), frontal baldness (66.7%), pharyngeal globus (62.9%), choking or coughing during and/or at the end of swallowing (62.9%), cataracts (59.2%), dysphagia (55.6%), chest pain (55.6%), cognitive impairment (44.4%), dyspnea (44.4%). Of the patients, 22.2% had a previous history of pneumonia. Conclusion: The DM1 patients in this study presented an epidemiological profile consistent with that described in the literature. Non-motor manifestations are common and should be investigated, since complications such as bronchopneumonia are important causes of mortality in these patients and may negatively impact the quality of life. Therefore, DM1 patients require multidisciplinary monitoring and evaluation.
8
Miyata, Marcela Misao, Mariana Rabelo de Brito, Anamarli Nucci, and Marcondes Cavalcante França Jr. "Metabolic syndrome in patients with Duchenne muscular dystrophy." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.512.
Full textAbstract:
Introduction: Duchenne muscular dystrophy (DMD) is the most frequent muscle dystrophy in children. It is an X-linked condition caused by loss of function variants in the DMD gene. During disease course, affected patients lose lean body mass, become severely motor disabled and are often treated with long term steroids. All these factors pose them at increased risk for developing metabolic syndrome (MS), even as children. Surprisingly, there are few studies addressing this aspect in DMD cohorts, particularly in Brazil. Objectives: To estimate the frequency and risk factors for DMD-related MS in a Brazilian cohort. Methods: This is a cross-sectional study involving 33 patients with DMD regularly followed at Universidade Estadual de Campinas. All subjects underwent detailed clinical (blood pressure, body mass index, motor function) and laboratorial (serum glucose, glycated hemoglobin (HbA1c), cholesterol and triglyceride levels) evaluation. We also recorded demographic, genetic and steroid use (cumulative dose) data from each subject. MS was defined according to the international federation of diabetes criteria for children/teenagers. Results: Mean age of patients was 10.54 years and there were 60% of wheelchair bound. Most of them had either deletions (n = 15) or duplications (n = 6). None of the patients fulfilled the entire set of criteria for MS. However, particular clinical features of the syndrome were frequently found: Obesity in 60%, Central obesity in 70.36% and increased blood pressure in 21.7%. Glucose and Hb1Ac were normal in all individuals, but increased cholesterol and/or triglyceride levels were noticed in 33.33% of the patients. Conclusion: Metabolic abnormalities are frequent and should be actively investigated in DMD. The existing MS diagnostic criteria may not be adequate for these patients and contribute to underdiagnosis.
9
Silva, Letícia Duarte, MAHARA JOANNA SENA VIANA, and FERNANDA MELO GOMES. "O potencial psicotrópico da Jurema-preta (Mimosa tenuiflora) em um contexto religioso." In II Congresso Brasileiro de Biodiversidade Virtual. Revista Multidisciplinar de Educação e meio ambiente, 2022. http://dx.doi.org/10.51189/ii-conbiv/5471.
Full textAbstract:
Introdução: O uso de substâncias psicotrópicas é comumente utilizado em culturas tradicionais do nordeste do país, sob a perspectiva de processos de cura espiritual e física. Nos rituais indígenas no nordeste do Brasil, entre eles o Catimbó de Jurema, o conhecimento etnobotânico se faz presente na aplicação e manuseio dos vegetais pelos indivíduos. O dimetiltriptamina (DMT) pode ser encontrado em várias espécies da fauna e da flora. Tipificada de um alcalóide de triptamina, é responsável pelo efeito alucinógeno devido à sua atividade no Sistema Nervoso Central (SNC), competindo com os receptores de serotonina. Mimosa tenuiflora, família botânica Fabaceae, também conhecida por jurema-preta. Hábito arbóreo, caule revestido de espinhos, casca de cor castanho escura e rugosa. Folhas compostas de pequenos folíolos alternos, com sete pares de pinas. Inflorescência de espigas isoladas com flores alvas, pequenas. Frutos tipo vagem. Objetivos: O presente resumo teve como objetivo explanar e promover a conservação M. tenuiflora, tal qual suas propriedades psicotrópicas e medicinais. Material e métodos: Foi realizada uma pesquisa bibliográfica a partir de uma literatura etnobotânica, utilizando como palavras-chaves: Jurema-preta, etnobotânica, DMT, catimbó. Resultados: A Mimosa tenuiflora tem alta concentração de DMT extraído de suas raízes, que preparado a partir de elementos secretos, resulta em uma bebida enteógena (vinho da Jurema-preta), sagrada na perspectiva religiosa, segundo a doutrina Catimbó de Jurema, essa bebida, ocasiona efeitos psíquicos e físicos, possibilitando a transcendência e o elo de comunicação com os ancestrais. A DMT ingerida isoladamente via oral não promove os efeitos psicotrópicos devido às Monoamina Oxidase (MAO), enzimas catalizadoras presentes no fígado que associam-se às moléculas do DMT, impedindo que passem para a circulação sanguínea e ao SNC, reprimindo o seu efeito. Existem componentes naturais encontrados em espécies vegetais, que são inibidoras da MAO, como as β-carbolinas, permitindo o efeito psicotrópico do DMT. Conclusão: O vasto conhecimento fitoquímico pelas culturas tradicionais colabora para estudos científicos sobre o dimetiltriptamina e seus efeitos psicotrópicos. Desta maneira, a compreensão em torno do uso do vegetal, preparo da bebida e a propriedade do seu princípio ativo é fundamental.
10
Silva, Glaucian Alonço de Oliveira, Eduardha Santos Temponi Barroso, and Enrrico Bloise. "ANÁLISE NARRATIVA DAS ALTERAÇÕES HISTOPATOLÓGICAS PLACENTÁRIAS ASSOCIADAS AO DIABETES MELLITUS GESTACIONAL." In I Congresso On-line Nacional de Histologia e Embriologia Humana. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/rems/3215.
Full textAbstract:
Introdução: O Diabetes Mellitus Gestacional (DMG) é uma doença de caráter metabólico definida pela hiperglicemia e por complicações associadas, diagnosticadas pela primeira vez durante a gestação. O critério laboratorial para o diagnóstico de DMG, compreende o achado de dois valores de glicemia acima de dois desvios padrão da média. Essa comorbidade acomete em torno de 4,5% das gestantes no Brasil e em torno de 3% no mundo. O DMG implica em danos para a mãe e para o feto, pois provoca alterações histopatológicas, morfológicas e metabólicas em diversos órgãos, incluindo a placenta. Objetivos: Revisar as principais lesões histopatológicas placentárias associadas ao DMG em gestantes sem outras comorbidades, analisando suas frequências a partir dos artigos selecionados. Materiais e métodos: Revisão em inglês pelo PubMed, utilizando as palavras-chave: “gestacional diabetes”, “placenta” e “histopathology”. Foram analisados artigos entre os anos 2000-2022, e selecionados 37 artigos relevantes para formular uma revisão sobre os principais achados histopatológicos na placenta de gestantes portadoras de DMG. Resultados: Dentre as lesões mais frequentes relatadas em gestantes portadoras de DMG sem nenhuma outra comorbidade (como obesidade, hipertensão, pre-eclampsia, ISTs, etc) existente durante toda a gravidez, destacaram-se os seguintes achados: Imaturidade vilosa (15 artigos), Necrose Fibrinoide (14), Edema viloso (11), e Corioangiose (10), espessamento da membrana basal do sinciciotrofoblasto (5 ), depósito de glicogênio ( 5), espessamento vascular (4), presença de eritrócitos fetais nucleados (4) e aumento da presença de macrófagos (4). Conclusão: A placenta “diabética” apresenta diversas alterações histológicas como consequência dos valores glicêmicos elevados, implicando em lesões microscópicas não somente como resultado direto da DMG, mas também alterações compensatórias que atuam para contrapor hipóxia e inflamação local, os efeitos da má-nutrição materna e fetal, assim como de outros insultos específicos decorrentes da resistência a insulina transitória, característica do DMG . Tais alterações podem contribuir para o agravamento de um fenótipo fetal alterado comumente associado ao DMG e predispor este neonato a doenças cardiometabólicas durante a vida adulta.
Reports on the topic "Deo Max (DM7)"
1
Godet, A., M. Smit, C. Guilmette, and F. Fournier-Roy. La longue vie du Batholite de Decelles, Pontiac, Québec: les grenats à notre rescousse! Natural Resources Canada/CMSS/Information Management, 2024. http://dx.doi.org/10.4095/332509.
Full textAbstract:
Les granites peralumineux sont reconnus à l'échelle mondiale comme le produit magmatique final des cratons archéens. Cependant, leur durée, les conditions thermiques de leur mise en place, leur séquence de cristallisation, ainsi que les liens avec l'évolution tectonométamorphique des roches encaissantes et les systèmes minéralisés en métaux précieux, de base, et rares sont peu connus. Le Batholite de Decelles (c. 2670-2620 Ma) exposé dans le sud-est du craton du Supérieur au Québec, Canada est l'un des plus volumineux de la région, offrant une opportunité unique dmp;gt;'améliorer notre compréhension des conditions thermiques et de la mobilité des magmas et des fluides dans la croûte moyenne et supérieure. Nous présentons des nouvelles datations Lu-Hf et des cartes dmp;gt;'éléments traces sur grenat de trois échantillons de granite du Batholite de Decelles. Les nouvelles dates de 2668 ± 4 Ma, 2663 ± 5 Ma, 2656 ± 7 Ma sont indifférenciables (considérant les incertitudes) des dates Lu-Hf sur grenat et U-Pb sur monazite des unités métasédimentaires encaissantes. La cartographie des éléments traces in situ par LA-ICP-MS révèle une zonation compositionnelle systématique. Les grenats présentent un cur avec une zonation oscillatoire concentrique en Li, P, Sc, Ti, Y, Zr, REE, Hf, Th et U; et une surcroissance marquée par des concentrations relativement élevées en MREE, HREE et V, et de faibles concentrations en Li, Ti, P, Sm, Zr, Hf et U par rapport aux curs. Les résultats indiquent une origine magmatique des grenats par opposition aux grenats métamorphiques de la source avec une histoire de cristallisation complexe. Le contenu en éléments traces du grenat semble être contrôlé par des variations cinétiques de croissance et de diffusion à l'interface grenat-matrice, ainsi que par la cristallisation de phases majeures et accessoires telles que la muscovite, la monazite, l'apatite et le zircon. Dans l'ensemble, le grenat du Batholite de Decelles date le début de la cristallisation magmatique et son contenu en éléments traces enregistre son histoire complète. Les archives géochronologiques régionales indiquent une évolution commune des niveaux de croûte moyenne et supérieure avec un refroidissement progressif entre c. 2640 et c. 2620 Ma, associé à la migration et au refroidissement de fluides minéralisateurs.
2
Jakuba, Michael V., and Allisa J. Dalpe. Clio Operations Report for the AT50-10 Saito Cruise. Woods Hole Oceanographic Institution, 2024. http://dx.doi.org/10.1575/1912/69648.
Full textAbstract:
This report includes a dive-by-dive operations summary of Autonomous Underwater Vehicle (AUV) Clio during the AT50-10 expedition onboard R/V Atlantis from May-June 2023. Each dive contains information such as launch and recovery times, the payload, mission parameters, noted issues, data plots, and a dive log. Related datasets are hosted by the Biological and Chemical Oceanography Data Management Office (BCO-DMO).
3
Keller, David P., Neha Mehendale, and Tronje P. Kemena. Analysis (report) of high- resolution modelling of efficacy, and regional impacts of selected ocean NETs close to the deployment sites. OceanNets, 2023. http://dx.doi.org/10.3289/oceannets_d4.3_v1.
Full textAbstract:
Many recent ocean modelling studies have demonstrated the added value of enhanced horizontal resolution, although it comes at a high computational cost. However, few modeling studies of ocean-based CDR have been done at high resolution. Here we assess the effects of model resolution on two simulated ocean-based CDR methods, unequilibrated ocean alkalinity enhancement (OAE) and the direct marine capture (DMC) of CO2 from seawater (with assumed permanent storage), in experiments with the FOCI Earth system model. To do this we utilized two FOCI configurations, one with a 1/2° ocean resolution and the other with a 1/10° ocean nest in the N. Atlantic. Both configurations were run in a series of “paired” experiments with identical climate forcing and CDR deployments. We show that model resolution does appear to matter when simulating OAE and DMC. For OAE, parameterization of physical processes in the coarse resolution version of the model appears to overestimate how long alkalized waters stay in contact with the atmosphere and where they are transported. This results in large differences in OAE efficacy with almost twice as much carbon sequestered when the model resolution is coarse. For the DMC simulations, at one site there were clear differences in the compensating CO2 flux induced by DIC removal, which was again higher with a coarse resolution, while at the other site variability was high and differences were difficult to determine. At both DMC sites there were clear differences in circulation with the two model resolutions, and thus on downstream biogeochemistry. We suggest that well resolving ocean physics may be necessary to best calculate unequilibrated OAE and DMC efficacies and side effects. These results should be confirmed using other models and with different resolutions.
4
Cosio-Pascal, Enrique. The Debt Office and the Effective Debt Management Functions: An Institutional and Operational Framework. Inter-American Development Bank, 2006. http://dx.doi.org/10.18235/0009210.
Full textAbstract:
The paper aims to be a useful analytical and managerial support tool for the debt practitioners and for the academia. It provides an appropriate approach for developing countries, and offers a detailed and systematic blueprint in how to establishing an efficient Debt Management Office. This paper differentiates from other papers published on the subject at least in two aspects. The first one is the political relevance that is given to the decision making process as far as responsibility for fixing a global macroeconomic public debt management strategy is concerned. The second is that the approach is a functional analysis, that is, there is no need to have a specific structure for the debt office in order to analyse who and where the functions are carried out. The paper gives a clear and well-defined list of tasks for each one of the functions, and this leads to clear and structured functional responsibilities for the implementation of the back, middle and front office working organization structure. This paper is composed of five sections. The first one is an introduction to the concept of Effective Debt Management Functions. The second and the third are the description of the functions: the second for the Executive Functions, which are not necessarily a Debt Management Office (DMO) responsibility, and the third to the Operational Functions, which are the direct DMO responsibilities. The fourth section is devoted to the responsibilities that a DMO can be accountable for, that may vary from country to country. The last section addresses major issues on debt management, stressing the pragmatic analysis that the functional approach provides. There are two Annexes with open-ended lists of tasks for each one of the Effective Debt Management Functions.