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Journal articles on the topic 'Depå'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Wight, Wanessa D., Kwang-Hyung Kim, Christopher B. Lawrence, and Jonathan D. Walton. "Biosynthesis and Role in Virulence of the Histone Deacetylase Inhibitor Depudecin from Alternaria brassicicola." Molecular Plant-Microbe Interactions® 22, no. 10 (2009): 1258–67. http://dx.doi.org/10.1094/mpmi-22-10-1258.

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Depudecin, an eleven-carbon linear polyketide made by the pathogenic fungus Alternaria brassicicola, is an inhibitor of histone deacetylase (HDAC). A chemically unrelated HDAC inhibitor, HC toxin, was earlier shown to be a major virulence factor in the interaction between Cochliobolus carbonum and its host, maize. In order to test whether depudecin is also a virulence factor for A. brassicicola, we identified the genes for depudecin biosynthesis and created depudecin-minus mutants. The depudecin gene cluster contains six genes (DEP1 to DEP6), which are predicted to encode a polyketide synthase

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Ayer, S., and C. Benyajati. "The binding site of a steroid hormone receptor-like protein within the Drosophila Adh adult enhancer is required for high levels of tissue-specific alcohol dehydrogenase expression." Molecular and Cellular Biology 12, no. 2 (1992): 661–73. http://dx.doi.org/10.1128/mcb.12.2.661-673.1992.

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Developmental and tissue-specific transcription from the Adh distal promoter is regulated in part by the Adh adult enhancer, located 450 to 600 bp upstream from the distal RNA start site. We have characterized four proteins (DEP1 to DEP4), present in Drosophila tissue culture cell nuclear extracts, which bind to this enhancer. DEP1 and DEP2 bind to a positive cis-acting element (-492 to -481) and share nucleotide contacts. A small linker replacement deletion mutation, which disrupts the overlapping DEP1- and DEP2-binding sites, reduces Adh distal transcription in an alcohol dehydrogenase (ADH)

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Ayer, S., and C. Benyajati. "The binding site of a steroid hormone receptor-like protein within the Drosophila Adh adult enhancer is required for high levels of tissue-specific alcohol dehydrogenase expression." Molecular and Cellular Biology 12, no. 2 (1992): 661–73. http://dx.doi.org/10.1128/mcb.12.2.661.

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Developmental and tissue-specific transcription from the Adh distal promoter is regulated in part by the Adh adult enhancer, located 450 to 600 bp upstream from the distal RNA start site. We have characterized four proteins (DEP1 to DEP4), present in Drosophila tissue culture cell nuclear extracts, which bind to this enhancer. DEP1 and DEP2 bind to a positive cis-acting element (-492 to -481) and share nucleotide contacts. A small linker replacement deletion mutation, which disrupts the overlapping DEP1- and DEP2-binding sites, reduces Adh distal transcription in an alcohol dehydrogenase (ADH)

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4

Chao, Che-Yi, and Ja-Chen Lin. "Secret Image Sharing Revisited: Forbidden Type, Support Type, and Their Two Approaches." Applied Sciences 10, no. 11 (2020): 3753. http://dx.doi.org/10.3390/app10113753.

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In this paper, we introduce two new image-sharing types to extend the applicability of sharing. Type 1 is our so-called forbidden type. In its sharing system, any t of the n shares can recover the secret image, unless the t shares form a forbidden group listed in a forbidden list. Type 2 is our so-called cross-department support type. If a government has 3 departments {DEPH, DEPM, DEPL}, then 3 thresholds (tH, tM and tL) exist. Any tH number of officers from department DEPH can unveil the secret image, and likewise for any tM and tL number of officers from departments DEPM and DEPL, respective

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5

Toyoshima, Kuniyoshi, Jiro Masuya, Miki Ono, et al. "Effects of the Interaction between Affective Temperaments and BIS/BAS on Depressive Symptoms in Individuals with Major Depressive Disorder." International Journal of Environmental Research and Public Health 19, no. 23 (2022): 15841. http://dx.doi.org/10.3390/ijerph192315841.

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Depressive symptoms (DepS) associated with major depressive disorder (MDD) are influenced by affective temperaments (ATs), behavioral inhibition system (BIS), and behavioral activation system (BAS). However, the effect of interactions between ATs and BIS/BAS on DepS in MDD remains poorly understood. Herein, we aimed to investigate the effects of these interactions. The Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A), BIS/BAS questionnaire, and Patient Health Questionnaire-9 (PHQ-9) were used to evaluate ATs, BIS/BAS, and DepS, respectively, in 90 part

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Boland, Sonja, Véronique Bonvallot, Thierry Fournier, Armelle Baeza-Squiban, Michel Aubier, and Francelyne Marano. "Mechanisms of GM-CSF increase by diesel exhaust particles in human airway epithelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 278, no. 1 (2000): L25—L32. http://dx.doi.org/10.1152/ajplung.2000.278.1.l25.

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We have previously shown that exposure to diesel exhaust particles (DEPs) stimulates human airway epithelial cells to secrete the inflammatory cytokines interleukin-8, interleukin-1β, and granulocyte-macrophage colony-stimulating factor (GM-CSF) involved in allergic diseases. In the present paper, we studied the mechanisms underlying the increase in GM-CSF release elicited by DEPs using the human bronchial epithelial cell line 16HBE14o−. RT-PCR analysis has shown an increase in GM-CSF mRNA levels after DEP treatments. Comparison of the effects of DEPs, extracted DEPs, or extracts of DEPs has s

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Kim, Byeong-Gon, Pureun-Haneul Lee, Jisu Hong, and An-Soo Jang. "Analyzing the Impact of Diesel Exhaust Particles on Lung Fibrosis Using Dual PCR Array and Proteomics: YWHAZ Signaling." Toxics 11, no. 10 (2023): 859. http://dx.doi.org/10.3390/toxics11100859.

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Air pollutants are associated with exacerbations of asthma, chronic bronchitis, and airway inflammation. Diesel exhaust particles (DEPs) can induce and worsen lung diseases. However, there are insufficient data to guide polymerase chain reaction (PCR) array proteomics studies regarding the impacts of DEPs on respiratory diseases. This study was performed to identify genes and proteins expressed in normal human bronchial epithelial (NHBE) cells. MicroRNAs (miRNAs) and proteins expressed in NHBE cells exposed to DEPs at 1 μg/cm2 for 8 h and 24 h were identified using PCR array analysis and 2D PA

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8

Hamadi, Naserddine, Sumaya Beegam, Nur Elena Zaaba, et al. "Protective Effects of Nerolidol on Thrombotic Events, Systemic Inflammation, Oxidative Stress, and DNA Damage Following Pulmonary Exposure to Diesel Exhaust Particles." Biomedicines 13, no. 3 (2025): 729. https://doi.org/10.3390/biomedicines13030729.

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Background/Objectives: Inhalation of environmental particulate air pollution has been reported to cause pulmonary and systemic events including coagulation disturbances, systemic inflammation, and oxidative stress. Nerolidol, a naturally occurring sesquiterpene alcohol, has effective antioxidant and anti-inflammatory effects. Hence, the aim in the present investigation was to evaluate the potential ameliorative effects of nerolidol on the coagulation and systemic actions induced by pulmonary exposure to diesel exhaust particles (DEPs). Methods: Nerolidol (100 mg/kg) was given to mice by oral g

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Chudakov, Dmitrii Borisovich, Mariya Vladimirovna Konovalova, Elena Igorevna Kashirina, et al. "DEPs Induce Local Ige Class Switching Independent of Their Ability to Stimulate iBALT de Novo Formation." International Journal of Environmental Research and Public Health 19, no. 20 (2022): 13063. http://dx.doi.org/10.3390/ijerph192013063.

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Background: Diesel exhaust particles (DEPs) are leading to a general increase in atopic diseases worldwide. However, it is still unknown whether DEPs induce systemic B-cell IgE class switching in secondary lymphoid organs or locally in the lungs in inducible bronchus-associated lymphoid tissue (iBALT). The aim of this work was to identify the exact site of DEP-mediated B-cell IgE class switching and pro-allergic antibody production. Methods: We immunized BALB/c mice with different OVA doses (0.3 and 30 µg) intranasally in the presence and absence of two types of DEPs, SRM1650B and SRM2786. We

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Cattani-Cavalieri, Isabella, Helber da Maia Valença, João Alfredo Moraes, et al. "Dimethyl Fumarate Attenuates Lung Inflammation and Oxidative Stress Induced by Chronic Exposure to Diesel Exhaust Particles in Mice." International Journal of Molecular Sciences 21, no. 24 (2020): 9658. http://dx.doi.org/10.3390/ijms21249658.

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Air pollution is mainly caused by burning of fossil fuels, such as diesel, and is associated with increased morbidity and mortality due to adverse health effects induced by inflammation and oxidative stress. Dimethyl fumarate (DMF) is a fumaric acid ester and acts as an antioxidant and anti-inflammatory agent. We investigated the potential therapeutic effects of DMF on pulmonary damage caused by chronic exposure to diesel exhaust particles (DEPs). Mice were challenged with DEPs (30 μg per mice) by intranasal instillation for 60 consecutive days. After the first 30 days, the animals were treate

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Boland, Sonja, Armelle Baeza-Squiban, Thierry Fournier, et al. "Diesel exhaust particles are taken up by human airway epithelial cells in vitro and alter cytokine production." American Journal of Physiology-Lung Cellular and Molecular Physiology 276, no. 4 (1999): L604—L613. http://dx.doi.org/10.1152/ajplung.1999.276.4.l604.

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The involvement of diesel exhaust particles (DEPs) in respiratory diseases was evaluated by studying their effects on two in vitro models of human airway epithelial cells. The cytotoxicity of DEPs, their phagocytosis, and the resulting immune response were investigated in a human bronchial epithelial cell line (16HBE14o−) as well as in human nasal epithelial cells in primary culture. DEP exposure induced a time- and dose-dependent membrane damage. Transmission electron microscopy showed that DEPs underwent endocytosis by epithelial cells and translocated through the epithelial cell sheet. Flow

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Kim, Ji Young, Jin-Hee Kim, Yong-Dae Kim, and Je Hoon Seo. "Ultrafine Diesel Exhaust Particles Induce Apoptosis of Oligodendrocytes by Increasing Intracellular Reactive Oxygen Species through NADPH Oxidase Activation." Antioxidants 11, no. 5 (2022): 1031. http://dx.doi.org/10.3390/antiox11051031.

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Diesel exhaust particles (DEPs) are a main contributor to air pollution. Ultrafine DEPs can cause neurodegenerative diseases by increasing intracellular reactive oxygen species (ROS). Compared with other cells in the brain, oligodendrocytes responsible for myelination are more susceptible to oxidative stress. However, the mechanisms underlying ROS generation in oligodendrocytes and the susceptibility of oligodendrocytes to ROS by ultrafine DEPs remain unclear. Herein, we examined the effects of excessive ROS generated by NOX2, an isoform of the NADPH oxidase family, after exposure to ultrafine

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13

Zhao, Tianchen, Julong Yuan, Qianfa Deng, Kaiping Feng, Zhaozhong Zhou, and Xu Wang. "Contrast Experiments in Dielectrophoresis Polishing (DEPP)/Chemical Mechanical Polishing (CMP) of Sapphire Substrate." Applied Sciences 9, no. 18 (2019): 3704. http://dx.doi.org/10.3390/app9183704.

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The broad applications of sapphire substrates in many fields warrants an urgent demand for a highly efficient and high precision polishing method for the sapphire substrates. The authors proposed a novel sapphire substrate polishing method that is based on the dielectrophoresis (DEP) effect. The principle of dielectrophoresis polishing (DEPP) is described. A non-uniform electric field was added in the polishing area to drive abrasives moving in the direction towards the plate by the DEP force. The amount of abrasives that participates in the polishing action increases as the distribution of po

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14

Li, Fangfang, Zhen An, Haibin Li, Xia Gao, Gui Wang, and Weidong Wu. "Involvement of Oxidative Stress and the Epidermal Growth Factor Receptor in Diesel Exhaust Particle-Induced Expression of Inflammatory Mediators in Human Mononuclear Cells." Mediators of Inflammation 2019 (November 15, 2019): 1–8. http://dx.doi.org/10.1155/2019/3437104.

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Exposure to diesel exhaust particles (DEPs) has been associated with increased incidence of cardiopulmonary diseases. This study is aimed at examining the proinflammatory effects of DEP on primary human peripheral blood mononuclear cells (PBMC) and the underlying mechanisms using a human mononuclear cell line, THP-1. DEPs were incubated with the PBMC and THP-1 cells for 24 h, respectively. The supernatants were collected and subjected to measurement of proinflammatory mediators including interleukin 8 (IL-8) or tumor necrosis factor α (TNFα) by ELISA. Levels of reactive oxygen species (ROS) we

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Nemmar, Abderrahim, Suhail Al-Salam, Sumaya Beegam, Priya Yuvaraju, and Badreldin H. Ali. "Thrombosis and systemic and cardiac oxidative stress and DNA damage induced by pulmonary exposure to diesel exhaust particles and the effect of nootkatone thereon." American Journal of Physiology-Heart and Circulatory Physiology 314, no. 5 (2018): H917—H927. http://dx.doi.org/10.1152/ajpheart.00313.2017.

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Adverse cardiovascular effects of particulate air pollution persist even at lower concentrations than those of the current air quality limit. Therefore, identification of safe and effective measures against particle-induced cardiovascular toxicity is needed. Nootkatone is a sesquiterpenoid in grapefruit with diverse bioactivities including anti-inflammatory and antioxidant effects. However, its protective effect on the cardiovascular injury induced by diesel exhaust particles (DEPs) has not been studied before. We assessed the possible protective effect of nootkatone (90 mg/kg) administered by

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16

Massimino, Luca, Alessandra Bulbarelli, Paola Antonia Corsetto, et al. "LSEA Evaluation of Lipid Mediators of Inflammation in Lung and Cortex of Mice Exposed to Diesel Air Pollution." Biomedicines 10, no. 3 (2022): 712. http://dx.doi.org/10.3390/biomedicines10030712.

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Airborne ultrafine particle (UFP) exposure is a great concern as they have been correlated to increased cardiovascular mortality, neurodegenerative diseases and morbidity in occupational and environmental settings. The ultrafine components of diesel exhaust particles (DEPs) represent about 25% of the emission mass; these particles have a great surface area and consequently high capacity to adsorb toxic molecules, then transported throughout the body. Previous in-vivo studies indicated that DEP exposure increases pro- and antioxidant protein levels and activates inflammatory response both in re

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17

Potharla, Vishwakanth Y., Shane R. Wesener, and Yi-Qiang Cheng. "New Insights into the Genetic Organization of the FK228 Biosynthetic Gene Cluster inChromobacterium violaceumNo. 968." Applied and Environmental Microbiology 77, no. 4 (2010): 1508–11. http://dx.doi.org/10.1128/aem.01512-10.

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ABSTRACTThe biosynthetic gene cluster of FK228, an FDA-approved anticancer natural product, was identified and sequenced previously. The genetic organization of this gene cluster has now been delineated through systematic gene deletion and transcriptional analysis. As a result, the gene cluster is redefined to contain 12 genes:depAthroughdepJ,depM, and a newly identified pathway regulatory gene,depR.

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18

Amara, Nadia, Rafik Bachoual, Mathieu Desmard, et al. "Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism." American Journal of Physiology-Lung Cellular and Molecular Physiology 293, no. 1 (2007): L170—L181. http://dx.doi.org/10.1152/ajplung.00445.2006.

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Chronic exposure to particulate air pollution is associated with lung function impairment. To determine the molecular mechanism(s) of this phenomenon, we investigated, in an alveolar human epithelial cell line (A549), whether diesel exhaust particles (DEPs), a main component of particulate air pollution, modulates the expression and activity of the matrix metalloprotease (MMP)-1, a collagenase involved in alveolar wall degradation. Interaction of DEPs with cigarette smoke, which also produces structural and functional lung alterations, was also investigated. A noncytotoxic concentration of DEP

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An, Hye Min, Young Suk Choi, Sung Kyoung Bae, and Young Koo Lee. "Effect of the Combination of Probiotics and Korean Red Ginseng on Diabetic Wound Healing Exposed to Diesel Exhaust Particles(DEPs)." Medicina 59, no. 6 (2023): 1155. http://dx.doi.org/10.3390/medicina59061155.

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Background and Objectives: Diesel exhaust particles (DEPs) are a major component of air pollution and adversely affect respiratory and cardiovascular disease and diabetic foot ulcers if diabetic patients are exposed to them. There are currently no studies on treating diabetic wounds exposed to DEPs. So, the effect of a combination of probiotics and Korean red ginseng on a diabetic wound model exposed to DEPs was confirmed. Materials and Methods: Rats were randomly divided into three groups according to DEP inhalation concentration and whether they underwent applications of probiotics (PB) and

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Mohammed, Bouzid, Djadi Amina, Guetaf H., and Bezzazi Boudjema. "Air Pollution from Diesel Particles and Chronic Obstruction Pulmonary Disease - CT Scan Study." European Scientific Journal, ESJ 13, no. 6 (2017): 504. http://dx.doi.org/10.19044/esj.2017.v13n6p504.

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Health problems have been observed in rabbits at low DEP concentration. The subject (animal) showed signs of chronic obstruction pulmonary disease (COPD). CT scan of the biopsy reveals significant emphysematous lesions. DEP grain causes inflammation of lung tissues around sites of deposition. Observations of tissue after formalin fixation reveal brown spots around the points of impact. It also reveals the double organic and inorganic aspect of DEPs. The organic compounds dissolve through slow diffusion in the lung physiological fluid while the inorganic part is partly handled by macrophages (p

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Ravala, Sandeep K., Jesse B. Hopkins, Caroline B. Plescia, et al. "The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding." Journal of Biological Chemistry 295, no. 36 (2020): 12635–47. http://dx.doi.org/10.1074/jbc.ra120.014534.

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Phosphatidylinositol (3,4,5)-trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) catalyzes the exchange of GDP for GTP on Rac GTPases, thereby triggering changes in the actin cytoskeleton and in transcription. Its overexpression is highly correlated with the metastasis of certain cancers. P-Rex1 recruitment to the plasma membrane and its activity are regulated via interactions with heterotrimeric Gβγ subunits, PIP3, and protein kinase A (PKA). Deletion analysis has further shown that domains C-terminal to its catalytic Dbl homology (DH) domain confer autoinhibition. Among these, the first

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Gibbs, Jonathan L., Blake W. Dallon, Joshua B. Lewis, et al. "Diesel Exhaust Particle Exposure Compromises Alveolar Macrophage Mitochondrial Bioenergetics." International Journal of Molecular Sciences 20, no. 22 (2019): 5598. http://dx.doi.org/10.3390/ijms20225598.

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Diesel exhaust particles (DEPs) are known pathogenic pollutants that constitute a significant quantity of air pollution. Given the ubiquitous presence of macrophages throughout the body, including the lungs, as well as their critical role in tissue and organismal metabolic function, we sought to determine the effect of DEP exposure on macrophage mitochondrial function. Following daily DEP exposure in mice, pulmonary macrophages were isolated for mitochondrial analyses, revealing reduced respiration rates and dramatically elevated H2O2 levels. Serum ceramides and inflammatory cytokines were inc

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Moon, Kuk-Young, Moo-Kyun Park, George D. Leikauf, Choon-Sik Park, and An-Soo Jang. "Diesel Exhaust Particle-Induced Airway Responses are Augmented in Obese Rats." International Journal of Toxicology 33, no. 1 (2014): 21–28. http://dx.doi.org/10.1177/1091581813518355.

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Air pollutants and obesity are important factors that contribute to asthma. The aim of this study was to assess the airway responsiveness and inflammation in Otsuka-Long Evans Tokushima Fatty (OLETF) obese rats and Long Evans Tokushima-Otsuka (LETO) nonobese rats exposed to diesel exhaust particles (DEPs). Otsuka Long Evans Tokushima fatty rats and LETO rats were exposed intranasally to DEP and then challenged with aerosolized DEP on days 6 to 8. Body plethysmography, bronchoalveolar lavage (BAL), and histology were performed. Enhanced pause (Penh) was measured as an indicator of airway resist

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Chen, Hao, Tsubasa Yamakawa, Masafumi Inaba, Michihiko Nakano, and Junya Suehiro. "Characterization of Extra-Cellular Vesicle Dielectrophoresis and Estimation of Its Electric Properties." Sensors 22, no. 9 (2022): 3279. http://dx.doi.org/10.3390/s22093279.

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Dielectrophoresis (DEP) refers to a type of electrical motion of dielectric particles. Because DEP is caused by particle polarization, it has been utilized to characterize particles. This study investigated the DEP of three types of exosomes, namely bovine milk, human breast milk, and human breast cancer exosomes. Exosomes are kinds of extracellular vesicles. The crossover frequencies of the exosomes were determined by direct observation of their DEPs. Consequently, bovine and human milk exosomes showed similar DEP properties, whereas the cancer exosomes were significantly different from the o

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Chen, Hao, Tsubasa Yamakawa, Masafumi Inaba, Michihiko Nakano, and Junya Suehiro. "Characterization of Extra-Cellular Vesicle Dielectrophoresis and Estimation of Its Electric Properties." Sensors 22, no. 9 (2022): 3279. http://dx.doi.org/10.3390/s22093279.

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Dielectrophoresis (DEP) refers to a type of electrical motion of dielectric particles. Because DEP is caused by particle polarization, it has been utilized to characterize particles. This study investigated the DEP of three types of exosomes, namely bovine milk, human breast milk, and human breast cancer exosomes. Exosomes are kinds of extracellular vesicles. The crossover frequencies of the exosomes were determined by direct observation of their DEPs. Consequently, bovine and human milk exosomes showed similar DEP properties, whereas the cancer exosomes were significantly different from the o

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Dorosz, Agata, Agata Penconek, and Arkadiusz Moskal. "Cold Plasma Gliding Arc Reactor System for Nanoparticles’ Removal from Diesel Cars’ Exhaust Gases." Processes 12, no. 9 (2024): 1841. http://dx.doi.org/10.3390/pr12091841.

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The main goal was to investigate the ability of a non-thermal plasma reactor with gliding arc discharge to remove diesel exhaust particulates (DEPs). A conventional knife-shaped LTP GA (low-temperature plasma gliding arc) reactor was utilized. The following three cases were studied: 140 L/min, 70 L/min, and 14 L/min of air drawn through the reactor, and diesel exhaust fumes were sampled continuously. They were assayed in terms of concentration and number particle size distribution. The higher the residence times, the higher the energy input that may be utilized for DEPs’ removal. The reactor p

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Zaaba, Nur Elena, та Abderrahim Nemmar. "Cardiotoxicity Induced by Intratracheal Instillation of Diesel Exhaust Particles in Mice, and the Protective Effects of Carnosol: Suppression of Inflammation and Oxidative and Nitrosative Stress via Modulation of NF-κb/MAPKs Signaling Pathways". Cellular Physiology and Biochemistry 58, № 3 (2024): 273–87. http://dx.doi.org/10.33594/000000707.

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Background/Aims: Inhaled particulate air pollution is associated with cardiotoxicity with underlying mechanisms including oxidative stress and inflammation. Carnosol, commonly found in rosemary and sage, is known to possess a broad range of therapeutic properties such as antioxidant, anti-inflammatory and antiapoptotic. However, its cardioprotective effects on diesel exhaust particles (DEPs)-induced toxicity have not been studied yet. Hence, we evaluated the potential ameliorative effects of carnosol on DEPs-induced heart toxicity in mice, and the underlying mechanisms involved. Methods: Mice

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Zhang, Xuting, Jinyuan Shan, Jiaxiu Wang, et al. "Comprehensive Proteome and Acetylome Analysis of Needle Senescence in Larix gmelinii." International Journal of Molecular Sciences 25, no. 13 (2024): 6824. http://dx.doi.org/10.3390/ijms25136824.

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Leaf senescence is essential for the growth and development of deciduous trees in the next season. Larix gmelinii, a deciduous coniferous tree, exhibits its most distinctive feature by turning yellow in the autumn and eventually shedding its leaves, resulting in significant changes in its appearance during the fall. Lysine acetylation plays an important role in diverse cellular processes; however, limited knowledge is available regarding acetylations in the needle senescence of L. gmelinii. In this study, the proteomics and acetylated modification omics of two phenotypic leaves, yellow and gre

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Nielsen, Michael Milek, Ove B. Schaffalitzky de Muckadell, and Stig Borbjerg Laursen. "Doppler-Guided Second-Look Endoscopy in Peptic Ulcer Bleeding: A Randomised Controlled Trial." Journal of Clinical Medicine 12, no. 21 (2023): 6722. http://dx.doi.org/10.3390/jcm12216722.

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Background: Endoscopic treatment guided by Doppler endoscopic probes (DEPs) during index endoscopy may be associated with improved outcome in patients with peptic ulcer bleeding (PUB). As competencies for DEP evaluation are not always available for index endoscopy, we examined the outcome associated with DEP evaluation at second-look endoscopy. Methods: The study was designed as a non-blinded, parallel group, randomised controlled trial. Patients admitted with PUB from Forrest Ia-IIb ulcers, controlled by endoscopic therapy, were randomised (1:1 ratio) to second-look endoscopy <24 h with DE

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Sagehashi, M., T. Fukuda, T. Fujii, Y. Sakai, and A. Sakoda. "Elution and adsorptive concentration of Japanese cedar (Cryptomeria japonica) pollen allergen in environmental water." Water Science and Technology 52, no. 8 (2005): 37–43. http://dx.doi.org/10.2166/wst.2005.0219.

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Elution of Japanese cedar pollen allergens (Cry j I and others) from pollen grains and its adsorptive concentration onto hydrophobic and hydrophilic surfaces were investigated using the surface plasmon resonance technique. Results showed that the allergen elution was obviously enhanced when the ion concentration was higher than that within the human body, indicating that the pollen tend to release its allergen in environmental water having a high ion concentration. However, higher adsorption capacity was observed on hydrophobic surface than hydrophilic surface. These results indicate that wate

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`Leslie, Sharon, and Professor Thomas Roche. "Assessment symposium assessment practice in a changing world." English Australia Journal 40, no. 2 (2024): 99–113. http://dx.doi.org/10.61504/xngh8651.

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The University English Centres of Australia (UECA) 'Assessment Symposium: Assessment Practice in a Changing World' at Southern Cross University in October 2022 highlighted the growing interest in integrated assessment in Australian university direct entry programs (DEPs) for English as Additional Language (EAL) students. In keynote presentations, Professor Antony John Kunnan, Carnegie Mellon University; Professor Guoxing Yu, University of Bristol; and Dr Paul Moore, the University of Queensland, shared an overview of their scholarly work on integrated assessment. The Symposium also included pr

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Karthikeyan, Subramanian, Dalibor Breznan, Errol M. Thomson, Erica Blais, Renaud Vincent, and Premkumari Kumarathasan. "Concordance between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends." Toxics 12, no. 4 (2024): 290. http://dx.doi.org/10.3390/toxics12040290.

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Diesel exhaust particles (DEPs) contribute to air pollution exposure-related adverse health impacts. Here, we examined in vitro, and in vivo toxicities of DEPs from a Caterpillar C11 heavy-duty diesel engine emissions using ultra-low-sulfur diesel (ULSD) and biodiesel blends (20% v/v) of canola (B20C), soy (B20S), or tallow–waste fry oil (B20T) in ULSD. The in vitro effects of DEPs (DEPULSD, DEPB20C, DEPB20S, and DEPB20T) in exposed mouse monocyte/macrophage cells (J774A.1) were examined by analyzing the cellular cytotoxicity endpoints (CTB, LDH, and ATP) and secreted proteins. The in vivo eff

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Korotkova, Natalia, та Mary E. Lidstrom. "Connection between Poly-β-Hydroxybutyrate Biosynthesis and Growth on C1 and C2 Compounds in the Methylotroph Methylobacterium extorquensAM1". Journal of Bacteriology 183, № 3 (2001): 1038–46. http://dx.doi.org/10.1128/jb.183.3.1038-1046.2001.

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ABSTRACT Several DNA regions containing genes involved in poly-β-hydroxybutyrate (PHB) biosynthesis and degradation and also in fatty acid degradation were identified from genomic sequence data and have been characterized in the serine cycle facultative methylotrophMethylobacterium extorquens AM1. Genes involved in PHB biosynthesis include those encoding β-ketothiolase (phaA), NADPH-linked acetoacetyl coenzyme A (acetyl-CoA) reductase (phaB), and PHB synthase (phaC).phaA and phaB are closely linked on the chromosome together with a third gene with identity to a regulator of PHB granule-associa

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Kohli, Manish, Joseph Finklestein, Xingyue Huo, et al. "Plasma proteome-based integrative prognostic nomogram in metastatic castrate-resistant prostate cancer (mCRPC)." Journal of Clinical Oncology 43, no. 5_suppl (2025): 225. https://doi.org/10.1200/jco.2025.43.5_suppl.225.

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225 Background: Currently non-specific clinical factors including non-tumor biology proteins (Alkaline Phosphatase-ALK, LDH, albumin) are used for identifying high, intermediate or low prognostic survival risk in mCRPC. We integrated these biomarkers with plasma proteins overexpressed exclusively in mCRPC to develop patient-centric nomograms for estimating 1,2 and 3-year (yr) overall survival (OS) probabilities. Methods: Proteomic profiling of plasma for 3072 proteins using Olink Explore NGS platform was performed in 32 local stage prostate cancer, 123 metastatic hormone-sensitive (mHSPC) and

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Warren, Cali E., Kennedy M. Campbell, Madison N. Kirkham, et al. "The Effect of Diesel Exhaust Particles on Adipose Tissue Mitochondrial Function and Inflammatory Status." International Journal of Molecular Sciences 25, no. 8 (2024): 4322. http://dx.doi.org/10.3390/ijms25084322.

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Air pollution poses a significant global health risk, with fine particulate matter (PM2.5) such as diesel exhaust particles (DEPs) being of particular concern due to their potential to drive systemic toxicities through bloodstream infiltration. The association between PM2.5 exposure and an increased prevalence of metabolic disorders, including obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM), is evident against a backdrop of rising global obesity and poor metabolic health. This paper examines the role of adipose tissue in mediating the effects of PM2.5 on metabolic health. Adip

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Palla, Luigi, and Suzana Almoosawi. "Diurnal Patterns of Energy Intake Derived via Principal Component Analysis and Their Relationship with Adiposity Measures in Adolescents: Results from the National Diet and Nutrition Survey RP (2008–2012)." Nutrients 11, no. 2 (2019): 422. http://dx.doi.org/10.3390/nu11020422.

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Mounting evidence points towards the existence of an association between energy intake in the evening and an increased prevalence and risk of being overweight and of obesity. The present study aimed to describe diurnal eating patterns (DEP) in a nationally representative sample of UK adolescents and to relate the derived DEP to anthropometrical measures. Data from four-day food records of adolescents aged 11–18 years participating in the 2008–2012 UK National Diet and Nutrition Survey Rolling Programme (NDNS RP) was utilised. The DEP were derived using a principal component analysis on the cor

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Zhai, Y., P. He, and R. Jia. "iTRAQ-based quantitative proteomic analysis of differentially expressed proteins in the hepatopancreas of Litopenaeus vannamei after WSSV infection." Diseases of Aquatic Organisms 145 (June 17, 2021): 51–61. http://dx.doi.org/10.3354/dao03594.

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White spot syndrome virus (WSSV) is the most destructive virus among invertebrates. In this study, we analyzed the immune response after WSSV infection in Pacific white shrimp Litopenaeus vannamei using isobaric tags for relative and absolute quantitation (iTRAQ). We identified 325 differentially expressed proteins (DEPs) in the hepatopancreas of L. vannamei. Among them, 212 were up-regulated proteins, and several of them might be related to immunity (e.g. arginine kinase and peroxiredoxin). Of the 113 down-regulated proteins, some were related to immunity (e.g. cathepsin C and cathepsin L) an

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Tesena, Parichart, Amornthep Kingkaw, Wanwipa Vongsangnak, et al. "Preliminary Study: Proteomic Profiling Uncovers Potential Proteins for Biomonitoring Equine Melanocytic Neoplasm." Animals 11, no. 7 (2021): 1913. http://dx.doi.org/10.3390/ani11071913.

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Equine melanocytic neoplasm (EMN) is a cutaneous neoplasm and is mostly observed in aged grey horses. This preliminary study aimed to identify potential proteins to differentiate normal, mild and severe EMN from serum proteomic profiling. Serum samples were collected from 25 grey horses assigned to three groups: normal (free of EMN; n = 10), mild (n = 6) and severe EMN (n = 9). To explore the differences in proteins between groups, proteomic profiling and analysis were employed. Accordingly, 8241 annotated proteins out of 8725 total proteins were compared between normal and EMN groups and insp

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Wang, Xin, Yaqiu Guo, and Meijian Wang. "Effects of dural puncture epidural technique with different drug delivery methods for labor analgesia: A randomized controlled clinical trial." Medicine 102, no. 38 (2023): e35217. http://dx.doi.org/10.1097/md.0000000000035217.

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This study aimed to investigate the effect of dural puncture epidural (DPE) combined with small-dose lidocaine for labor analgesia. Parturients were randomly divided into epidural anesthesia (EA), DPE1, and DPE2 groups. In the EA group, 5 mL of 1% lidocaine was administered via conventional L2–L3 puncture catheterization; in the DPE1 group, epidural drug was administered after catheterization using the DPE technique; in the DPE2 group, epidural puncture drug was administered through the epidural puncture needle before catheterization using the DPE technique. The primary outcome was the onset t

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Li, Shijie, Yan Cui, Sijiu Yu, et al. "Insights from Tandem Mass Tag (TMT) Proteomic Analysis on Protein Network Modification in Control of Yak Hair Follicle Cycle." International Journal of Molecular Sciences 26, no. 4 (2025): 1532. https://doi.org/10.3390/ijms26041532.

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Highland animals have unique hair growth mechanisms to allow them to adapt to harsh living environments. Compared with other species, their hair cycle growth is affected by more environmental factors. Yaks, as highland animals, have obvious periodic hair growth characteristics in a year; this biological process is regulated by numerous proteins, but the specific molecular regulatory mechanism is still unclear. Here we analyzed the histological characteristics of yak hair follicles (HFs) at each stage and conducted TMT proteomics research. The protein expression network of yak hair at each stag

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Doornaert, Blandine, Valerie Leblond, Stephane Galiacy, et al. "Negative impact of DEP exposure on human airway epithelial cell adhesion, stiffness, and repair." American Journal of Physiology-Lung Cellular and Molecular Physiology 284, no. 1 (2003): L119—L132. http://dx.doi.org/10.1152/ajplung.00039.2002.

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Epidemiological and experimental studies suggest that diesel exhaust particles (DEPs) may be associated with increased respiratory mortality and morbidity. Several recent studies have also shown that DEPs increase the production of inflammatory cytokines by human bronchial epithelium (HBE) cells in vitro. The present study investigates the effects of DEPs on the interaction of l-HBE cells (16HBE14o-) with the cell and matrix microenvironment based on evaluation of integrin-type cell/matrix ligand expression, cytoskeleton (CSK) stiffness, and matrix remodeling via matrix metalloproteinase (MMP)

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Mojtaba, Ehsanifar, Montazeri Zeinab, and Rafati Mehravar. "Neurotoxicity related exposure to ambient nanoparticles." Journal of Neuroscience and Neurological Disorders 6, no. 1 (2022): 005–10. http://dx.doi.org/10.29328/journal.jnnd.1001060.

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Air pollution exposure is among the most prevalent reasons for environmentally-induced oxidative stress and inflammation, both of which are implicated in the central nervous system (CNS) diseases. The CNS has emerged as an important target for adverse health effects of exposure to air pollutants, where it can cause neurological and neurodevelopmental disorders. Air pollution includes various components of gases, particulate matter (PM), ultraﬁne particulate (UFPs), metals, and organic compounds. An important source of PM and UFPM in the ambient air is associated with air pollution-related traf

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Olmez-Hanci, T., I. Kabdaşlı, O. Tünay, Ç. Ecer, and B. Aydın. "A statistical experimental design approach for mineralization and detoxification of diethyl phthalate by H2O2/UV-C process." Water Science and Technology 68, no. 4 (2013): 856–62. http://dx.doi.org/10.2166/wst.2013.315.

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In the present study, a three-factor central composite design (CCD) was implemented to evaluate the major factors (treatment time, initial H2O2 dose and initial diethyl phthalate (DEP) concentration) influencing the H2O2/UV-C treatment of aqueous DEP solution. Significant regression models for total organic carbon (TOC) removal and residual H2O2 concentration were derived using analysis of variance (ANOVA), which were found to be adequate to perform the process variables optimization. According to the applied ANOVA, treatment time (positive effect) and initial H2O2 dose (negative effect after

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Lu, Chang, Zhi-Feng Luo, Donge Tang, et al. "Proteomic analysis of glomeruli, tubules and renal interstitium in idiopathic membranous nephropathy (IMN): A statistically observational study." Medicine 102, no. 50 (2023): e36476. http://dx.doi.org/10.1097/md.0000000000036476.

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Idiopathic membranous nephropathy (IMN) is a common type of primary glomerulonephritis, which pathogenesis are highly involved protein and immune regulation. Therefore, we investigated protein expression in different microregions of the IMN kidney tissue. We used laser capture microdissection and mass spectrometry to identify the proteins in the kidney tissue. Using MSstats software to identify the differently expressed protein (DEP). Gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis were used to predict and enrich the potential functions of the DEPs, and DEPs

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Zeng, Wenjing, Yunling Peng, Xiaoqiang Zhao, et al. "Comparative Proteomics Analysis of the Seedling Root Response of Drought-sensitive and Drought-tolerant Maize Varieties to Drought Stress." International Journal of Molecular Sciences 20, no. 11 (2019): 2793. http://dx.doi.org/10.3390/ijms20112793.

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The growth and development of maize roots are closely related to drought tolerance. In order to clarify the molecular mechanisms of drought tolerance between different maize (Zea mays L.) varieties at the protein level, the isobaric tags for relative and absolute quantitation (iTRAQ) quantitative proteomics were used for the comparative analysis of protein expression in the seedling roots of the drought-tolerant Chang 7-2 and drought-sensitive TS141 maize varieties under 20% polyethylene glycol 6000 (PEG 6000)-simulated drought stress. We identified a total of 7723 differentially expressed pro

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Stoyanova, A., G. Ganchev, and V. Kuneva. "Influence of foliar feeding of common wheat varieties on the nutritional value of the grain." Agricultural Science and Technology 10, no. 4 (2018): 333–37. http://dx.doi.org/10.15547/10.15547/ast.2018.04.061.

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Abstract. Two years of polls from the field trials of the Faculty of Agriculture, Trakia University, Stara Zagora, Bulgaria were used for the purpose of the survey. In the period 2015-2016, two varieties of common wheat (Apolon and Bolonga), treated by leaf liquid fertilizers, imported alone and in combinations were tested under field conditions. Main fertilization with ammonium nitrate was done. The variants of the experiments were as follows: 1) Without fertilization (Control); 2) Ammonium nitrate (N140); 3) Lactifrost – l0.0 L/ha; 4) Lactifros + Lactofol base – 10.0 L/ha + 5.0 L/ha; 5) Lact

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GÓMEZ-ALDAPA, CARLOS A., ESMERALDA RANGEL-VARGAS, M. del REFUGIO TORRES-VITELA, ANGÉLICA VILLARRUEL-LÓPEZ, and JAVIER CASTRO-ROSAS. "Behavior of Non-O157 Shiga Toxin–Producing Escherichia coli, Enteroinvasive E. coli, Enteropathogenic E. coli, and Enterotoxigenic E. coli Strains on Alfalfa Sprouts." Journal of Food Protection 76, no. 8 (2013): 1429–33. http://dx.doi.org/10.4315/0362-028x.jfp-13-060.

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Data about the behavior of non-O157 Shiga toxin–producing Escherichia coli (non-O157 STEC), enteroinvasive E. coli (EIEC), enterotoxigenic E. coli (ETEC), and enteropathogenic E. coli (EPEC) on seeds and alfalfa sprouts are not available. The behavior of STEC, EIEC, ETEC, and EPEC was determined during germination and sprouting of alfalfa seeds at 20 ± 2°C and 30 ± 2°C and on alfalfa sprouts at 3 ± 2°C. When alfalfa seeds were inoculated with STEC, EIEC, ETEC, or EPEC strains, all these diarrheagenic E. coli pathotypes (DEPs) grew during germination and sprouting of seeds, reaching counts of a

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Val, J. E., A. S. Ferraudo, L. A. F. Bezerra, et al. "Alternativas para seleção de touros da raça Nelore considerando características múltiplas de importância econômica." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 60, no. 3 (2008): 705–12. http://dx.doi.org/10.1590/s0102-09352008000300027.

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Os dados são provenientes de 234 touros da raça Nelore participantes de um teste de progênie, no período de 1996 a 2003. A diferença esperada na progênie (DEP) de sete características: peso aos 120 e 210 dias, efeito materno (DMPP120 e DMPP210), peso e perímetro escrotal aos 365 e 450 dias, efeito direto (DDP365, DDP450, DDPE365 e DDPE450) e idade ao primeiro parto (DDIPP) foi utilizada para classificar os animais em três grupos, assim como identificar quais as características possuíram maior poder discriminatório na formação de cada grupo. Para tanto, foram utilizados procedimentos estatístic

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Li, Ying-Ying, Jin-Xian Yang, Xi Chen, Qiang Chen, Tie-Ying Song, and Jun-Qing Ge. "Proteomic Profiling Skin Mucus of European Eel Anguilla anguilla Infected with Anguillid Herpesvirus." International Journal of Molecular Sciences 23, no. 19 (2022): 11283. http://dx.doi.org/10.3390/ijms231911283.

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Anguillid herpesvirus 1 (AngHV) is an important viral pathogen affecting eel. This study was designed to investigate the potential molecular mechanisms and immune response elicited at the protein levels in the skin mucus of AngHV-infected Anguilla anguilla. Tandem mass tag (TMT)-labelling proteomics with the liquid chromatography tandem mass spectrometry (LC-MS/MS) was used for performing quantitative identification of the proteins. In addition, the quantitative protein amount was detected by parallel reaction monitoring (PRM) analysis. A total of 3486 proteins were identified, of which 2935 w

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Yue, Lin, Zengkui Lu, Tingting Guo, Jianbin Liu, Bohui Yang, and Chao Yuan. "Proteome Analysis of Alpine Merino Sheep Skin Reveals New Insights into the Mechanisms Involved in Regulating Wool Fiber Diameter." International Journal of Molecular Sciences 24, no. 20 (2023): 15227. http://dx.doi.org/10.3390/ijms242015227.

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Wool fiber is a textile material that is highly valued based on its diameter, which is crucial in determining its economic value. To analyze the molecular mechanisms regulating wool fiber diameter, we used a Data-independent acquisition-based quantitative proteomics approach to analyze the skin proteome of Alpine Merino sheep with four fiber diameter ranges. From three contrasts of defined groups, we identified 275, 229, and 190 differentially expressed proteins (DEPs). Further analysis using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways revealed that pathways

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