Log in

Relevant bibliographies by topics / Department of Internal Medicine / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Department of Internal Medicine.

Dissertations / Theses on the topic 'Department of Internal Medicine'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Department of Internal Medicine.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Ajudua, Emmanuel Enuagwuna. "Profile of diabetic complications amongst diabetics attending internal medicine outpatient department and family medicine outpatient department in Dora Nginza Hospital, PE hospital complex." Thesis, Stellenbosch : University of Stellenbosch, 2015. http://hdl.handle.net/10019.1/97196.

Full text

Abstract:

Thesis (MFamMed)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Introduction: Diabetes is the most prevalent endocrinology problem encountered in primary care practice. If recent trends showing a dramatic increase in prevalence (believed to be a consequence of a decline in physical activity and excessive caloric intake) continue, then the condition will soon affect nearly 20 million people in the U.S a reflection of the global trend. Effective management requires care that is thoughtful and meticulous, incorporating intensive patient education. Euglycemic control, with the level of glyco

APA, Harvard, Vancouver, ISO, and other styles

2

Kwong, Kenneth. "Derivation and Internal Validation of a Clinical Prediction Tool for Adult Emergency Department Syncope Patients." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34620.

Full text

Abstract:

Syncope is a common Emergency Department (ED) presentation. An important proportion of syncope patients are at risk of developing serious adverse events (SAEs), such as deaths or arrhythmias following ED disposition. Currently, no clinically-useful decision tool exists to reliably identify high-risk patients. This study derived a clinical decision tool to identify syncope patients at risk of developing SAEs after ED disposition. This study also examined key methodological considerations involved in deriving decision tools by comparing two different methodological approaches: a traditional and

APA, Harvard, Vancouver, ISO, and other styles

3

Olsson, Thomas. "Risk Prediction at the Emergency Department." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4632.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Jaber, Hassan, and Enock Nana Mensah. "Knowledge Sharing in the Internal Audit Department." Thesis, Högskolan Dalarna, Företagsekonomi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:du-34362.

Full text

Abstract:

Aim: This study aims to investigate the factors that affect the practices of effective knowledge sharing in the Middle East region. Method: The research paper is based on a single case study about the internal audit department in a commercial Lebanese bank. Qualitative research methods have been applied which included semi-structured interviews. Results & Conclusion: The research results suggest that organizational, individual and IT are the factors affecting knowledge sharing practices at the bank. However, one of the main issues is related to the national cultural and more specifically t

APA, Harvard, Vancouver, ISO, and other styles

5

Mišelnický, Tomáš. "Data Analysis in the Internal Audit Department." Master's thesis, Vysoká škola ekonomická v Praze, 2016. http://www.nusl.cz/ntk/nusl-203905.

Full text

Abstract:

The aim of this thesis is to present a draft model for better planning internal audit engagements of branch network of the bank. The first part deals with the internal audit. It presents and discusses the definition of internal auditing by the Institute of Internal Auditors (IIA). Other relevant disciplines are also included - external audit and assurance. The importance of these disciplines is demonstrated in the example of Enron. The thesis presents the International Professional Practices Framework, especially its key components - standards. The end of this section is devoted to a descripti

APA, Harvard, Vancouver, ISO, and other styles

6

Patel, Vaishal J. "MGH Internal Medicine Associates : primary care redesign." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/99015.

Full text

Abstract:

Thesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, 2015. In conjunction with the Leaders for Global Operations Program at MIT.<br>Thesis: S.M., Massachusetts Institute of Technology, Engineering Systems Division, 2015. In conjunction with the Leaders for Global Operations Program at MIT.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 105-107).<br>Internal Medicine Associates (IMA) is the largest primary care practice at Massachusetts General Hospital (MGH) with over 40 attending physicians, 60 residents, and 80 support sta

APA, Harvard, Vancouver, ISO, and other styles

7

Dodd, Will. "Adolescent Medicine." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/8913.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Wang, Ling, and Shunbin Ning. "Viral and Cellular MicroRNAs in Regulation of EBV Latency and Oncogenesis." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/6543.

Full text

Abstract:

Epstein-Barr virus (EBV), an oncogenic virus that ubiquitously establishes life-long persistence in humans, encodes viral miRNAs in two clusters, BHRF1 and BART. EBV also regulates expression of a large pool of cellular miRNAs, including miR-155, miR-146a, miR-21, miR-29, and miR-34a. These miRNAs targets both viral and cellular genes involved in the entire viral lifetime from lytic infection to oncogenesis, including viral replication, immune responses, cell cycle regulation, apoptosis, and cell proliferation, and are indispensable for persistent infection, latency establishment and maintenan

APA, Harvard, Vancouver, ISO, and other styles

9

Mbhele, Senelisiwe. "Internal communication in achieving employee engagement within a South African government department." Diss., University of Pretoria, 2016. http://hdl.handle.net/2263/60508.

Full text

Abstract:

Internal communication has evolved into an element that is crucial for organisational success in the sense that it underpins organisational effectiveness. Internal communication has become a precursor for organisational existence. This growing importance has led to internal communication becoming a pressing issue for organisations as they strive to achieve employee engagement and organisational effectiveness (Welch & Jackson, 2007; Welch, 2012; Welch, 2013). Employee engagement has become a concern for leaders in public, private and voluntary organisations. The concept of employee engagement g

APA, Harvard, Vancouver, ISO, and other styles

10

Qi, Ling S. M. Massachusetts Institute of Technology. "Predicting department of medicine inpatients' discharges at US hospitals." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/117962.

Full text

Abstract:

Thesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, in conjunction with the Leaders for Global Operations Program at MIT, 2018.<br>Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, in conjunction with the Leaders for Global Operations Program at MIT, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (page 67).<br>In the last few years, US hospitals have faced severe challenges with bed capacity management that leads to capacity congestion. Delivering patients to the right bed at the righ

APA, Harvard, Vancouver, ISO, and other styles

11

Arias, Peregrina Leticia Elizabeth. "The Value Added by the Purchasing Department to the Organization." Thesis, KTH, Industriell ekonomi och organisation (Inst.), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-102851.

Full text

Abstract:

The role of purchasing has been evolving during the last years, increasing its strategic importance inside the organization. Traditionally viewed as a supportive function impacting only the bottom-line of the company, the main performance indicators for purchasing were cost-reduction and savings. Nowadays, organizations recognize the importance of the value added generated in the purchasing processes and they are broadening their vision of purchasing as a strategic contributor of value in both economical and intangible aspects. One of the main intangible value contributions from the purchasi

APA, Harvard, Vancouver, ISO, and other styles

12

Ning, Shunbin, and Ling Wang. "Identification of PP1 as the First Phosphatase for IRF7." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/6527.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Dodd, Will. "Pediatric Emergency Medicine." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etsu-works/8915.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Setshedi, Mashiko. "Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/11788.

Full text

Abstract:

The most common risk factors for chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) include chronic alcohol abuse and infection with hepatitis B (HBV) or hepatitis C (HCV) virus. Growing evidence from human studies and experimental models suggests that pre-degenerative and premalignant abnormalities include disturbances in intracellular signaling and ongoing injury with oxidative stress, inflammation, and lipotoxicity. The major signal transduction pathways affected in both degenerative and neoplastic disease states in liver include: insulin/IGF, Wnt/β-catenin, and other

APA, Harvard, Vancouver, ISO, and other styles

15

Gina, Ntombenhle Phindile. "Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20834.

Full text

Abstract:

Point-of-care detection of urine lipoarabinomannan (LAM) is a low-cost rapid TB diagnostic for use in HIV co-infected patients. However, its sensitivity in these patients is suboptimal. Strategies to improve its performance is a need. The hypothesis was that early morning urine (EMU), rather than random urine sampling, would improve LAM's sensitivity. Methods Recruitment process conducted between June 2012 and February 2014 for HIV-infected patients from four hospitals in Cape Town, South Africa presenting with possible TB (all patients initiated on TB treatment). Fresh random and early mornin

APA, Harvard, Vancouver, ISO, and other styles

16

Viljoen, Charle André. "Audit of the quality and cost of acute inpatient stroke care in the general medical wards at Groote Schuur Hospital." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/21377.

Full text

Abstract:

Introduction: Stroke is the leading cause of death and disability amongst South Africans older than 60 years. The majority of stroke patients in South Africa are managed in general medical wards where little is known about the quality and cost of care. The aim of this study was to determine the cost of stroke care and to identify factors associated with increased expense , as well as to evaluate the quality of stroke care in general medical wards in order to identify areas where quality of care could be improved. Methods: We conducted a retrospective folder review of all acute stroke

APA, Harvard, Vancouver, ISO, and other styles

17

Wasserman, Sean. "Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/3493.

Full text

Abstract:

Includes abstract.<br>Includes bibliographical references.<br>Stroke is an important cause of death and disability in sub-Saharan Africa. Recombinant tissue plasminogen activator (tPA) thrombolysis is effective in treating acute ischaemic stroke, but may not be a viable option in developing countries. This prospective observational study was designed to assess the short-termoutcomes and safety of tPA for the treatment of stroke at Groote Schuur Hospital.Data was collected from January 2000 to February 2012, and included patients witha clinical diagnosis of acute stroke with onset of stroke sym

APA, Harvard, Vancouver, ISO, and other styles

18

Nzeale, Jean Jacques Noubiap. "Prevalence of dyslipidaemia among adults in Africa: a systematic review and meta-analysis." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31183.

Full text

Abstract:

Background The burden of dyslipidaemia in Africa remains inadequately characterised. We aimed to estimate the prevalence of dyslipidaemia in African adults from hospital-based and community-based studies. Methods In this systematic review and meta-analysis, we searched MEDLINE via PubMed, EMBASE, African Journals Online, and African Index Medicus for studies published between Jan 1, 1980, and July 31, 2017, without language restriction. We assessed methodological quality of all crosssectional studies reporting on the prevalence of elevated concentrations of total cholesterol, LDL c

APA, Harvard, Vancouver, ISO, and other styles

19

Rush, Colin James. "The effect of structured reflection on the diagnostic accuracy of postgraduate trainees during real patient encounters." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/22819.

Full text

Abstract:

Structured reflection has been shown to improve the diagnostic competence of undergraduate and postgraduate trainees in a range of experimental settings using written case scenarios. Evidence supporting the use of this strategy during real patient encounters is lacking. This paper reports on a study conducted to determine the effects of structured reflection on the diagnostic accuracy of postgraduate medical trainees during bedside tutorials using real patient encounters. Method Fifty-five postgraduate trainees in Internal Medicine at the University of Cape Town, South Africa, were prospective

APA, Harvard, Vancouver, ISO, and other styles

20

Poulet, Erma. "Implementation of the JAK2V617F mutation analysis in the pathway of suspected myeloproliferative neoplasms in Groote Schuur Hospital." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/23660.

Full text

Abstract:

We studied the implementation of JAK2 mutation analysis in conjunction with the World Health Organisation (WHO) guidelines in the pathway to MPN diagnosis in 279 patients presenting with one of three clinical scenarios: erythrocytosis, OR leukocytosis and/or thrombocytosis and/or splenomegaly; OR patients with thrombosis without cytoses. Patients were investigated for MPN and managed in the haematology clinic of Groote Schuur Hospital. We studied the association of clinical and laboratory variables with clonal vs non-clonal diagnoses. In 120/297 patients MPN was confirmed: Polycythemia vera (P

APA, Harvard, Vancouver, ISO, and other styles

21

Pang, Hon-wah, and 彭瀚華. "The development of an internal quality assurance system in Construction Branch, Housing Department." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1992. http://hub.hku.hk/bib/B31265467.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Steward, LaTresa, Dale A. Haney, and David A. Kobie. "Evaluation of the Department of the Navy's (DoN's) Managers Internal Control (MIC) manual." Monterey, California. Naval Postgraduate School, 2008. http://hdl.handle.net/10945/10323.

Full text

Abstract:

MBA Professional Report<br>The purpose of this MBA project was to conduct a comprehensive review of the current DoN Manager's Internal Control (MIC) Manual to evaluate its effectiveness in helping to align the Navy's current mission, organizational philosophy, management strategy, goals, metrics, sustainment efforts, and improvement programs. Additionally, this study reviews the (MIC) manual to evaluate its ease of use or identify potential challenges in applying the concepts as outlined in the aforementioned manual. The primary framework used in evaluating the MIC manual was a report publ

APA, Harvard, Vancouver, ISO, and other styles

23

Steward, LaTresa Kobie David A. Haney Dale A. "Evaluation of the Department of the Navy's (DoN's) Managers Internal Control (MIC) manual." Monterey, Calif. : Naval Postgraduate School, 2008. http://edocs.nps.edu/npspubs/scholarly/MBAPR/2008/Dec/08Dec%5FSteward%5FMBA.pdf.

Full text

Abstract:

"Submitted in partial fulfillment of the requirements for the degree of Master of Business Administration from the Naval Postgraduate School, December 2008."<br>Advisor(s): Euske, Kenneth ; Potvin, Lisa. "December 2008." "MBA professional report"--Cover. Description based on title screen as viewed on January 28, 2009. Includes bibliographical references (p. 95-97). Also available in print.

APA, Harvard, Vancouver, ISO, and other styles

24

Pang, Hon-wah. "The development of an internal quality assurance system in Construction Branch, Housing Department /." [Hong Kong : University of Hong Kong], 1992. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13302565.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Ghaffari, Faezeh, and Arash Mozafari. "Improvements in Internal Logistics : A Case Study at SSAB Oxelösund - Logistics Development Department." Thesis, Linköpings universitet, Produktionsekonomi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158068.

Full text

Abstract:

Internal logistics is a combined performance of human resources, machines, transportation, and storage system. Thus, different elements and factors are involved in the internal transportation such as human factors and system functions. Moreover, Internal transportation is an important part of production activities because of its close cooperation with production processes. Since the largest portion of the logistics costs is related to transportation, improvements in transportation will lead to a significant increase in profits. The purpose of this thesis is to make improvements in the internal

APA, Harvard, Vancouver, ISO, and other styles

26

Reid, Tracey. "The impact of physician communication skills on continuity of care and emergency department use by regular emergency department users /." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21629.

Full text

Abstract:

Regular use of the emergency department is associated with a patient's inability to identify a regular primary care physician. Continuity of the physician-patient relationship is largely determined by patient satisfaction, which in turn is influenced by the physician's communication and interpersonal skills. The objective of this study was to estimate the relationship between the communication competency of newly licensed family physicians and the ambulatory health care utilization behaviour of their regular emergency department users. It was hypothesized that physicians with higher levels of

APA, Harvard, Vancouver, ISO, and other styles

27

Ning, Shunbin. "Interferon Regulatory Factors and Autoimmune Diseases." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/6542.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Ugarph, Elizabeth. "Patient flow optimization in the Department of Medicine at MGH." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111536.

Full text

Abstract:

Thesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, in conjunction with the Leaders for Global Operations Program at MIT, 2017.<br>Thesis: S.M. in Engineering Systems, Massachusetts Institute of Technology, School of Engineering, Institute for Data, Systems, and Society, in conjunction with the Leaders for Global Operations Program at MIT, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 119-120).<br>In 2015, there were approximately 17,000 General Medicine admissions in the Department of Medicine (DOM) at MGH. General

APA, Harvard, Vancouver, ISO, and other styles

29

Sydorchuk, L. P., Oksana Anatoliivna Petrynych, R. I. Sydorchuk, et al. "ENHANCING AUDIOVISUALS FOR LECTURES AND PRESENTATIONS IN FAMILY MEDICINE DEPARTMENT." Thesis, Матеріали навчально-методичної конференції «АКТУАЛЬНІ ПИТАННЯ ВИЩОЇ МЕДИЧНОЇ ТА ФАРМАЦЕВТИЧНОЇ ОСВІТИ: ДОСВІД, ПРОБЛЕМИ, ІННОВАЦІЇ ТА СУЧАСНІ ТЕХНОЛОГІЇ», 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/12374.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Mendes, Georges. "Tradução de um capítulo do Harrison’s principles of internal medicine." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14876.

Full text

Abstract:

Mestrado em Tradução Especializada<br>No âmbito do Mestrado em Tradução Especializada, vertente Saúde e Ciências da Vida, este projeto procura explorar a metodologia e a problemática associada à atividade tradutológica, através da realização de uma tradução de um capítulo da obra Harrison’s Principles of Internal Medicine, subordinado ao tema da Aterosclerose, explorando a patogenia, prevenção e tratamento daquela que é uma das principais causas de mortalidade nos países ocidentais. Além da tradução, este projeto consiste também na análise de todos os processos ultrapassados antes de se inici

APA, Harvard, Vancouver, ISO, and other styles

31

Kallis, Constantinos. "Construction and assessment of risk models in medicine." Thesis, University of Warwick, 2005. http://wrap.warwick.ac.uk/79266/.

Full text

Abstract:

This thesis investigates the application of classical and contemporary statistical methods in medical research attempting to bridge the gap between statistics and clinical medicine. The importance of using simple and advanced statistical methods in constructing and assessing risk models in medicine will be demonstrated by empirical studies related to vascular complications: namely abdominal aortic aneurysm and diabetic retinopathy. First, data preprocessing and preliminary statistical analysis are examined and their application is investigated using data on abdominal aortic aneurysm. We illust

APA, Harvard, Vancouver, ISO, and other styles

32

Mahomed, Zeyn. "Emergency department patients' perception of care: do doctors understand their patients?" Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/11526.

Full text

Abstract:

Includes abstract.<br>Includes bibliographical references (leaves 42-55).<br>The aim of my study is to directly compare the patient’s perceptions of care received in the emergency department to that of the attending physician’s. The aim is to give us better insight into how the patient experiences their care, with a view to improving the level of care offered. The study elucidates the emphasis a patient places on aspects of their care such as empathy, communication, waiting times, etc. The study was conducted at GF Jooste Emergency Department over a period of eight weeks. Patients voluntarily,

APA, Harvard, Vancouver, ISO, and other styles

33

Panchal, Hemang B., Kalpit Devani, Shimin Zheng, et al. "Impact of Chronic Kidney Disease on Guideline Directed Interventions Among Patients Admitted With Acute ST-Elevation Myocardial Infarction: A Nationwide Inpatient Sample 2012-2014." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/6305.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Wang, Ling, and Shunbin Ning. ""Toll-Free" Pathways for Production of Type I Interferons." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/6540.

Full text

Abstract:

Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are recognized by different cellular pathogen recognition receptors (PRRs), which are expressed on cell membrane or in the cytoplasm of cells of the innate immune system. Nucleic acids derived from pathogens or from certain cellular conditions represent a large category of PAMPs/DAMPs that trigger production of type I interferons (IFN-I) in addition to pro-inflammatory cytokines, by specifically binding to intracellular Toll-like receptors or cytosolic receptors. These cytosolic receptors, which are

APA, Harvard, Vancouver, ISO, and other styles

35

Cegelka, Derek S. "End-of-Life Training in US Internal Medicine Residency Programs: A National Study." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1461679801.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Carlin, Christopher M. "The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1484/.

Full text

Abstract:

Chronic hypoxia, in animals and man, results in remodelling of the pulmonary vasculature with consequent pulmonary hypertension. The pulmonary artery fibroblast (PAF) has been shown to play an early and important role in hypoxia-induced pulmonary vascular remodelling. In acute and chronic hypoxia there is excess proliferation of PAFs. Morevoer, it is likely that cell-cell interactions between hypoxia-stimulated PAFs and other vascular cells – particularly smooth muscle cells - initiates and progresses the changes that occur in pulmonary vascular remodelling in the other vessel compartments. Al

APA, Harvard, Vancouver, ISO, and other styles

37

Neisius, Ulf. "Proteomic, circulating and functional biomarkers of cardiovascular disease." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4740/.

Full text

Abstract:

Cardiovascular disease is the leading cause of morbidity and mortality in the Western world, mainly through cerebrovascular and coronary artery related events. Cardiovascular disease is a chronic progressive disease with different stages. These stages can be assessed by a variety of biomarkers. Biomarker quantification can be used for different purposes: screening, prediction of disease recurrence, therapeutic monitoring, diagnosis and prognostication. Noninvasive, inexpensive diagnostic tests currently applied in clinical practice have a relative high rate of false positive and false negative

APA, Harvard, Vancouver, ISO, and other styles

38

Martin, Steven Carl. "Homocysteine and vascular disease." Thesis, University of Glasgow, 2003. http://theses.gla.ac.uk/30939/.

Full text

Abstract:

Cardiovascular disease is multifactorial. The main risk factors for developing cardiovascular disease (age, sex, smoking, diabetes, hyperlipidaemia and hypertension) do not explain its development in everyone. New risk factors are continually being sought in order to better understand and treat the disease process. In recent years homocysteine has been proposed as a risk factor for the development of premature cardiovascular disease as a consequence of the accelerated arterial and venous thrombotic disease seen in homocystinuria as a result of a single gene defect. This theory has been difficu

APA, Harvard, Vancouver, ISO, and other styles

39

Stevenson, Judith L. "An investigation of attitudes and attentional biases in trichotillomania." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/31012/.

Full text

Abstract:

Trichotillomania (TTM) is a body focussed repetitive behaviour (BFRB) characterised by the repetitive pulling out of one’s hair. It is a moderately new disorder having only been classified in 1987 and it is under-researched relative to other psychological disorders. This thesis investigates TTM by presenting a series of experiments designed to further understand attitudes towards, and attentional biases in, TTM. The experiments in this thesis address 3 central issues: stigmatising attitudes towards TTM; attentional bias pertaining to the experience of shame in TTM; and attentional bias towards

APA, Harvard, Vancouver, ISO, and other styles

40

Shaw, Aaron Robert James. "Sleep, anxiety and the effects on cognition." Thesis, University of Warwick, 2018. http://wrap.warwick.ac.uk/114458/.

Full text

Abstract:

Poor sleep and high levels of anxiety have a detrimental effect on cognitive functioning. However, very little is known about what cognitive functions are affected by poor sleep or high levels of anxiety and if some are more affected than others. This thesis informs the understanding of poor sleep and anxiety with a focus on generalised anxiety disorder and how they affect specific cognitive functioning namely Attention and Working Memory. Chapter one is a systematic literature review of the qualitative research exploring how sleep deprivation impacts on the cognitive functioning of people wit

APA, Harvard, Vancouver, ISO, and other styles

41

Spooner, Joshua. "People's experiences of living with severe health conditions." Thesis, University of Warwick, 2018. http://wrap.warwick.ac.uk/114471/.

Full text

Abstract:

Treating people living with severe health conditions has, and always will be, a fundamental part of the National Health Service. Given the complex nature of conditions such as Huntington's Disease and Cancer, research exploring the impact severe health conditions can have on those affected is of paramount importance. Chapter one is a systematic review utilising a meta-ethnographic approach to explore qualitative research portraying people's experiences of genetic testing for Huntington's Disease (HD). Electronic databases cataloguing relevant research were searched which, combined with manual

APA, Harvard, Vancouver, ISO, and other styles

42

Eddowes, Peter John. "The role of MRI in stratifying and evaluating chronic liver disease." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8126/.

Full text

Abstract:

Chronic liver disease is a highly prevalent condition associated with significant morbidity and mortality. There is need for clinicians to stratify chronic liver disease and for researchers to define meaningful study endpoints. Currently this is often reliant on liver biopsy histology, which is known to be a flawed gold standard. There is a need to develop novel, non-invasive techniques for the evaluation of chronic liver disease that are accurate and reliable. In this thesis I have demonstrated that multiparametric MRI can stage hepatic fibrosis in an unselected cohort with performance compar

APA, Harvard, Vancouver, ISO, and other styles

43

Redgrave, Liam Stephen. "The role of supercoiling in altering chromosome structure, gene expression and antibiotic resistance in bacteria." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7912/.

Full text

Abstract:

Antibiotic resistance is a major problem estimated to cost $100 trillion and cause 10 million deaths per year by 2050. Despite novel molecules targeting Gram-positive bacteria, there are no new antibiotics active against Gram-negatives. To prolong use of current drugs, we need to understand mechanisms of resistance to inform prescribing practices and drug discovery. Quinolone resistance is primarily conferred by mutations in the target loci: DNA gyrase (gyrA) and topoisomerase IV. Quinolone resistance arising from gyrA mutations has also been shown to confer a low level of protection against a

APA, Harvard, Vancouver, ISO, and other styles

44

Dinsdale, Robert Jonathon. "Production and impaired regulation of neutrophil extracellular traps following severe thermal injury, implications for sepsis and multiple organ failure." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7958/.

Full text

Abstract:

Advancements in burn care have improved immediate outcome, however, the prevalence of sepsis and multiple organ failure (MOF) remain significant. Although well characterised the mechanisms responsible for the pathogenesis of MOF and increased propensity to infection are poorly understood. Neutrophil extracellular traps (NETs) provide protection against invading pathogens but also contribute to thrombosis. Sepsis is required for NET generation following severe thermal injury. Quantification of circulating NET biomarkers shows good discriminatory power for diagnosis of sepsis. Interestingly, neu

APA, Harvard, Vancouver, ISO, and other styles

45

Ward, Lewis Stuart Corey. "Interactions of mesenchymal stromal cells with their microenvironment." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8278/.

Full text

Abstract:

Mesenchymal stromal cells (MSC) suppress the inflammatory infiltrate through crosstalk with neighbouring endothelium. However, this response is lost at chronic inflammatory sites where stromal cells instead support leukocyte recruitment and upregulate expression of podoplanin. The mechanism and function by which this inflammatory phenotype is established is unknown. We hypothesise that MSC modulation of endothelium is also altered by exposure to inflammatory cytokines, and that expression of podoplanin confers an invasive phenotype, enabling the interaction of these perivascular MSC with circu

APA, Harvard, Vancouver, ISO, and other styles

46

Dominguez, Medina Carmen Coral. "Investigation of how antibody to the outer membrane porin D from Salmonella typhimurium binds and protects against infection." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8572/.

Full text

Abstract:

The induction of specific-antibody that targets the surface of a pathogen or its secreted components is the basis of immunological memory to natural infection and vaccination. This antibody, induced after natural infection or vaccination, saves millions of lives every year. The few vaccines against Gram-negative bacteria either target one antigen, the surface capsular polysaccharides, or are complex vaccines involving the whole organism or complex mixtures of multiple antigens. In this project, we studied how antibody binds to the Salmonella outer membrane porin D (STm-OmpD) on the bacterial s

APA, Harvard, Vancouver, ISO, and other styles

47

Redzuan, Adyani Md. "Sodium-dietary intake, awareness and clinical outcomes in treated hypertensive patients." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/4418/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

McElroy, Daniel. "Elucidating the functions of fibroblast growth factor 9 in multiple sclerosis." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30798/.

Full text

Abstract:

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. In around 85% of cases, the disease progresses through two distinct stages: relapsing-remitting MS (RRMS) is driven by repeated bouts of demyelination caused by autoimmune inflammation; and progressive MS, in which inflammation gives way to neurodegenerative processes that lead to axonal loss and the steady accumulation of disability. There is no cure for MS and the majority of disease-slowing treatments target the immune response in RRMS. These interventions are ineffective in progressive MS and other tr

APA, Harvard, Vancouver, ISO, and other styles

49

Liu, Hui-Hsuan. "Investigation of the role of nutrients for protection against acute kidney injury." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/44162/.

Full text

Abstract:

Ischaemia reperfusion injury and nephrotoxicity are the common insults of acute kidney injury. Drug induced nephrotoxicity can also lead to an ischaemic phenomenon. The key mediator to both insults is oxidative injury caused by reactive oxygen species, and prolonged injury can result in irreversible kidney fibrosis and chronic kidney disease. This thesis developed a simulated ischaemia reperfusion injury in an in-vitro model to investigate whether amino acid supplementation may facilitate human proximal tubule cell recovery and protect from H2O2 damage following starvation and whether this was

APA, Harvard, Vancouver, ISO, and other styles

50

Gaya, Daniel R. "Investigating the role of faecal calprotectin in luminal gastroenterology." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8745/.

Full text

Abstract:

Providing a sensitive, non-invasive, cheap marker of disease activity inflammatory bowel disease (IBD) comprises an area of ongoing interest and unmet clinical need. In previous years, options included only serum CRP (poorly sensitive and specific), colonoscopy (invasive, costly, perforation risk, inability to view proximal small bowel), CT (costly, ionising radiation risk) and radiolabelled white cell scanning (costly, poor sensitivity). My thesis describes a series of trials performed to establish the role of faecal calprotectin to define current disease activity in IBD patients. Prompted by

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!