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Journal articles on the topic 'Dependent eliminators'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kogo, Hiroshi, Makiko Tsutsumi, Tamae Ohye, Hidehito Inagaki, Takaya Abe, and Hiroki Kurahashi. "HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes." Genes to Cells 17, no. 6 (2012): 439–54. http://dx.doi.org/10.1111/j.1365-2443.2012.01600.x.

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2

Elkins, T., B. Ganetzky, and C. F. Wu. "A Drosophila mutation that eliminates a calcium-dependent potassium current." Proceedings of the National Academy of Sciences 83, no. 21 (1986): 8415–19. http://dx.doi.org/10.1073/pnas.83.21.8415.

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3

Huang, Yulong, and Jeremy Yallop. "Defunctionalization with Dependent Types." Proceedings of the ACM on Programming Languages 7, PLDI (2023): 516–38. http://dx.doi.org/10.1145/3591241.

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The defunctionalization translation that eliminates higher-order functions from programs forms a key part of many compilers. However, defunctionalization for dependently-typed languages has not been formally studied. We present the first formally-specified defunctionalization translation for a dependently-typed language and establish key metatheoretical properties such as soundness and type preservation. The translation is suitable for incorporation into type-preserving compilers for dependently-typed languages

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4

Martínez, Carmen, Covadonga López, Agustín Hidalgo, Manuel Sánchez, and María José García de Boto. "Gonadectomy Eliminates Endothelium-Dependent Diethylstilbestrol-Induced Relaxant Effect in Rat Aorta." Pharmacology 67, no. 3 (2003): 136–42. http://dx.doi.org/10.1159/000067800.

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5

Ko, Sungjin, Laura Molina, Junyan Tao, et al. "Simultaneous Yap and Sox9 repression eliminates Notch‐dependent hepatocyte‐driven cholangiocarcinogenesis." FASEB Journal 34, S1 (2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.04899.

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6

J�rgensen, Even H., and Malcolm Jobling. "Feeding in darkness eliminates density-dependent growth suppression in Arctic charr." Aquaculture International 1, no. 1 (1993): 90–93. http://dx.doi.org/10.1007/bf00692666.

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7

Stumpner, Andreas. "Picrotoxin Eliminates Frequency Selectivity of an Auditory Interneuron in a Bushcricket." Journal of Neurophysiology 79, no. 5 (1998): 2408–15. http://dx.doi.org/10.1152/jn.1998.79.5.2408.

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Stumpner, Andreas. Picrotoxin eliminates frequency selectivity of an auditory interneuron in a bushcricket. J. Neurophysiol. 79: 2408–2415, 1998. AN1, an auditory interneuron in the bushcricket Ancistrura nigrovittata, is narrowly tuned to the male song frequency (∼15 kHz). It receives pronounced inhibitory input at frequencies below and, more prominently, above this fundamental frequency. It is also subject to side-dependent inhibition producing asymmetric response functions for left- and right-side stimulation. In addition, intensity-response functions of AN1 peak as stimulus intensities inc

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8

Chochia, G. A., P. K. Chawdhry, and C. R. Burrows. "A computer algebra-based coordinate reduction technique for multi-body systems." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 214, no. 2 (2000): 313–21. http://dx.doi.org/10.1243/0954406001522985.

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This paper presents a heuristic algorithm to solve the linear coordinate reduction problem. If Cartesian coordinates are chosen in the initial formulation the algorithm eliminates two-thirds of dependent coordinates in the planar case and one-half in the spatial case for mechanisms composed of spherical, revolute and universal joints. For an open-loop system composed of spherical joints it eliminates all dependent coordinates. A computer algebra-based implementation in the Maple language is presented. The proposed technique is demonstrated by application to the dynamic analysis of a Peaucellie

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Konno, Hiroyasu, Jeonghyun Ahn, and Glen Barber. "Loss of STING eliminates proinflammatory gene induction in TrexI-/- deficient mice. (P4091)." Journal of Immunology 190, no. 1_Supplement (2013): 127.17. http://dx.doi.org/10.4049/jimmunol.190.supp.127.17.

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Abstract Patients defective in the 3’ repair exonuclease 1 (Trex1) suffer from Aicardi-Goutieres Syndrome (AGS) which instigates lethal encephalitis characterized by high levels of type I IFN production being present in the cerebrospinal fluid. Trex1 deficient mice exhibit a median life span of approximately 9 weeks since as yet uncharacterized self-DNA, presumably normally digested by Trex1, activates intracellular DNA sensors which triggers cytokine production and causes lethal inflammatory aggravated myocarditis. STING is essential for triggering cytoplasmic DNA-dependent innate immune sign

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10

Ko, Bangwon, and Qihe Tang. "Sums of Dependent Nonnegative Random Variables with Subexponential Tails." Journal of Applied Probability 45, no. 1 (2008): 85–94. http://dx.doi.org/10.1239/jap/1208358953.

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In this paper we study the asymptotic tail probabilities of sums of subexponential, nonnegative random variables, which are dependent according to certain general structures with tail independence. The results show that the subexponentiality of the summands eliminates the impact of the dependence on the tail behavior of the sums.

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11

Ko, Bangwon, and Qihe Tang. "Sums of Dependent Nonnegative Random Variables with Subexponential Tails." Journal of Applied Probability 45, no. 01 (2008): 85–94. http://dx.doi.org/10.1017/s0021900200003971.

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In this paper we study the asymptotic tail probabilities of sums of subexponential, nonnegative random variables, which are dependent according to certain general structures with tail independence. The results show that the subexponentiality of the summands eliminates the impact of the dependence on the tail behavior of the sums.

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12

Zhong, Zhenyu, Atsushi Umemura, Elsa Sanchez-Lopez та ін. "NF-κB restricts NLRP3 inflammasome activation via p62-dependent mitophagy which eliminates mitochondrial signals". Journal of Immunology 196, № 1_Supplement (2016): 62.5. http://dx.doi.org/10.4049/jimmunol.196.supp.62.5.

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Abstract NF-κB, a key activator of inflammation primes the NLRP3-inflammasome for activation by inducing pro-IL-1β and NLRP3 expression. NF-κB, however, also prevents excessive inflammation and restrains NLRP3-inflammasome activation through a poorly defined mechanism. We now show that NF-κB exerts its anti-inflammatory activity by inducing delayed accumulation of the autophagy receptor p62/SQSTM1. External NLRP3-activating stimuli trigger a form of mitochondrial (mt) damage that is caspase-1- and NLRP3-independent and causes release of direct NLRP3-inflammasome activators, including mtDNA and

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13

Qiu, W., X. Wang, B. Leibowitz, et al. "Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis." Proceedings of the National Academy of Sciences 107, no. 46 (2010): 20027–32. http://dx.doi.org/10.1073/pnas.1010430107.

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14

Zhao, Lisa Y., April L. Colosimo, Yue Liu, Yanping Wan, and Daiqing Liao. "Adenovirus E1B 55-Kilodalton Oncoprotein Binds to Daxxand Eliminates Enhancement of p53-Dependent Transcription byDaxx." Journal of Virology 77, no. 21 (2003): 11809–21. http://dx.doi.org/10.1128/jvi.77.21.11809-11821.2003.

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ABSTRACT The adenovirus E1B 55-kDa protein impairs the p53 pathway and enhances transformation, although the underlying mechanisms remain to be defined. We found that Daxx binds to the E1B 55-kDa protein in a yeast two-hybrid screen. The two proteins interact through their C termini. Mutation of three potential phosphorylation sites (S489/490 and T494 to alanine) within the E1B 55-kDa protein did not affect its interaction with Daxx, although such mutations were previously shown to inhibit E1B's ability to repress p53-dependent transcription and to enhance transformation. In addition to their

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15

Balaian, Larissa, Mary Donohoe, Phoebe Mondala, et al. "Cirmtuzumab (Zilovertamab) Eliminates ROR1 Positive Leukemia Stem Cells By Blocking Niche Dependent ROR1/WNT5a Signaling." Blood 140, Supplement 1 (2022): 3356–57. http://dx.doi.org/10.1182/blood-2022-170128.

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16

Shim, A. L., V. M. Mitrokhin, V. E. Kazanski, M. I. Mladenov, and A. G. Kamkin. "Discrete Stretch Eliminates Electrophysiological Dose-Dependent Effects of Nitric Oxide Donor SNAP in Rat Atrium." Bulletin of Experimental Biology and Medicine 163, no. 6 (2017): 705–9. http://dx.doi.org/10.1007/s10517-017-3885-9.

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17

Mortensen, Ole V. "MKP3 eliminates depolarization-dependent neurotransmitter release through downregulation of L-type calcium channel Cav1.2 expression." Cell Calcium 53, no. 3 (2013): 224–30. http://dx.doi.org/10.1016/j.ceca.2012.12.004.

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18

Leitch, Jeffry M., and Anthony Carruthers. "ATP-dependent sugar transport complexity in human erythrocytes." American Journal of Physiology-Cell Physiology 292, no. 2 (2007): C974—C986. http://dx.doi.org/10.1152/ajpcell.00335.2006.

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Human erythrocyte glucose sugar transport was examined in resealed red cell ghosts under equilibrium exchange conditions ([sugar]intracellular = [sugar]extracellular, where brackets indicate concentration). Exchange 3- O-methylglucose (3MG) import and export are monophasic in the absence of cytoplasmic ATP but are biphasic when ATP is present. Biphasic exchange is observed as the rapid filling of a large compartment (66% cell volume) followed by the slow filling of the remaining cytoplasmic space. Biphasic exchange at 20 mM 3MG eliminates the possibility that the rapid exchange phase represent

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19

Muntinga, Jaap H. J., and Henk A. Schuil. "Effects of automatic item eliminations based on item test analysis." Advances in Physiology Education 31, no. 3 (2007): 247–52. http://dx.doi.org/10.1152/advan.00019.2007.

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Item test analysis is an aid to identify items that need to be eliminated from an assessment. An automatic elimination procedure based on item statistics, therefore, could help to increase the quality of a test in an objective manner. This was investigated by studying the effect of a standardized elimination procedure on the test results of a second-year course over a period of 6 successive years in 1,624 candidates. Cohort effects on the item elimination were examined by determining the number of additional items that had to be eliminated from three different tests in 3 successive academic ye

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20

Upton, Rosalynd, Allison Banuelos, Dongdong Feng, et al. "Combining CD47 blockade with trastuzumab eliminates HER2-positive breast cancer cells and overcomes trastuzumab tolerance." Proceedings of the National Academy of Sciences 118, no. 29 (2021): e2026849118. http://dx.doi.org/10.1073/pnas.2026849118.

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Trastuzumab, a targeted anti-human epidermal-growth-factor receptor-2 (HER2) monoclonal antibody, represents a mainstay in the treatment of HER2-positive (HER2+) breast cancer. Although trastuzumab treatment is highly efficacious for early-stage HER2+ breast cancer, the majority of advanced-stage HER2+ breast cancer patients who initially respond to trastuzumab acquire resistance to treatment and relapse, despite persistence of HER2 gene amplification/overexpression. Here, we sought to leverage HER2 overexpression to engage antibody-dependent cellular phagocytosis (ADCP) through a combination

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21

Tohnai, Genki, Hiroaki Adachi, Masahisa Katsuno, et al. "Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy." Human Molecular Genetics 23, no. 13 (2014): 3552–65. http://dx.doi.org/10.1093/hmg/ddu066.

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22

Patel, Jitandra R., Gary M. Diffee, Xu Pei Huang, and Richard L. Moss. "Phosphorylation of Myosin Regulatory Light Chain Eliminates Force-Dependent Changes in Relaxation Rates in Skeletal Muscle." Biophysical Journal 74, no. 1 (1998): 360–68. http://dx.doi.org/10.1016/s0006-3495(98)77793-8.

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23

Miller, Diane B., and Frederic J. Seidler. "Prenatal cocaine eliminates the sex-dependent differences in activation observed in adult rats after cocaine challenge." Brain Research Bulletin 33, no. 2 (1994): 179–82. http://dx.doi.org/10.1016/0361-9230(94)90248-8.

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24

ROTMAN, H. L., S. SCHNYDER‐CANDRIAN, P. SCOTT, T. J. NOLAN, G. A. SCHAD, and D. ABRAHAM. "IL‐12 eliminates the Th‐2 dependent protective immune response of mice to larval Strongyloides stercoralis." Parasite Immunology 19, no. 1 (1997): 29–39. http://dx.doi.org/10.1046/j.1365-3024.1997.d01-142.x.

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25

Voichek, Guy, and Nathan Novemsky. "Asymmetric Hedonic Contrast: Pain Is More Contrast Dependent Than Pleasure." Psychological Science 32, no. 7 (2021): 1038–46. http://dx.doi.org/10.1177/0956797621991140.

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Research has shown that hedonic-contrast effects are a ubiquitous and important phenomenon. In eight studies ( N = 4,999) and four supplemental studies ( N = 1,809), we found that hedonic-contrast effects were stronger for negative outcomes than for positive outcomes. This asymmetric-contrast effect held for both anticipated and experienced affect. The effect makes risks that include gains and losses more attractive in the presence of high reference points because contrast diminishes the hedonic impact of losses more than gains. We demonstrated that the effect occurs because people are general

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26

Ji, Yinduo, Andrea Marra, Martin Rosenberg, and Gary Woodnutt. "Regulated Antisense RNA Eliminates Alpha-Toxin Virulence in Staphylococcus aureus Infection." Journal of Bacteriology 181, no. 21 (1999): 6585–90. http://dx.doi.org/10.1128/jb.181.21.6585-6590.1999.

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ABSTRACT The ability to selectively disrupt gene function remains a critical element in elucidating information regarding gene essentiality for bacterial growth and/or pathogenesis. In this study, we adapted atet regulatory expression system for use inStaphylococcus aureus, with the goal of downregulating gene expression via induction of antisense RNA. We demonstrate that this system exhibits a 50- to 100-fold dose-dependent level of induction in bacterial cells grown in culture (i.e., in vitro) and also functions in mice (i.e., in vivo) following oral administration of inducer. To determine w

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27

Loh, John T., Mark H. Forsyth, and Timothy L. Cover. "Growth Phase Regulation of flaA Expression in Helicobacter pylori Is luxS Dependent." Infection and Immunity 72, no. 9 (2004): 5506–10. http://dx.doi.org/10.1128/iai.72.9.5506-5510.2004.

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ABSTRACT LuxS plays a role in the synthesis of an extracellular signaling molecule, autoinducer 2 (AI-2). To analyze a possible role of AI-2 in regulating Helicobacter pylori gene expression, we constructed a panel of transcriptional reporter strains. We show that the expression of H. pylori flaA is growth phase dependent and that flaA transcription increases in association with increased culture density. Mutating the luxS gene eliminates growth-phase-dependent control of flaA, and this growth phase dependence is restored when the luxS mutant strain is complemented with the wild-type luxS gene

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28

CHANG, FUNG-YUEL, and OMAR WING. "TRANSIENT SIMULATION OF LOSSY COUPLED TRANSMISSION LINES CHARACTERIZED WITH FREQUENCY-DEPENDENT PARAMETERS." International Journal of High Speed Electronics and Systems 02, no. 04 (1991): 319–53. http://dx.doi.org/10.1142/s0129156491000156.

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The method of characteristics is generalized to simulate the transient response of coupled transmission lines, which are characterized with frequency-dependent parameters. The discrete-time transient simulation is carried out from the equivalent decoupled transmission lines with an arbitrary set of characteristic impedances. The method eliminates the time-consuming convolution integration and has been adapted for iterative waveform relaxation simulation using the Fast Fourier Transform (FFT) for reduction of simulation cost. Examples are given to substantiate the accuracy and the efficiency of

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29

Ryu, Hyunju, Maiko Furuta, Donald Kirkpatrick, Steven P. Gygi та Yoshiaki Azuma. "PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity". Journal of Cell Biology 191, № 4 (2010): 783–94. http://dx.doi.org/10.1083/jcb.201004033.

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DNA topoisomerase IIα (TopoIIα) is an essential chromosome-associated enzyme with activity implicated in the resolution of tangled DNA at centromeres before anaphase onset. However, the regulatory mechanism of TopoIIα activity is not understood. Here, we show that PIASy-mediated small ubiquitin-like modifier 2/3 (SUMO2/3) modification of TopoIIα strongly inhibits TopoIIα decatenation activity. Using mass spectrometry and biochemical analysis, we demonstrate that TopoIIα is SUMOylated at lysine 660 (Lys660), a residue located in the DNA gate domain, where both DNA cleavage and religation take p

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30

Meyer, S. N., M. Amoyel, C. Bergantiños, et al. "An ancient defense system eliminates unfit cells from developing tissues during cell competition." Science 346, no. 6214 (2014): 1258236. http://dx.doi.org/10.1126/science.1258236.

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Developing tissues that contain mutant or compromised cells present risks to animal health. Accordingly, the appearance of a population of suboptimal cells in a tissue elicits cellular interactions that prevent their contribution to the adult. Here we report that this quality control process, cell competition, uses specific components of the evolutionarily ancient and conserved innate immune system to eliminate Drosophila cells perceived as unfit. We find that Toll-related receptors (TRRs) and the cytokine Spätzle (Spz) lead to NFκB-dependent apoptosis. Diverse “loser” cells require different

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31

Roehle, Kevin, Li Qiang, Katherine S. Ventre, et al. "cIAP1/2 antagonism eliminates MHC class I–negative tumors through T cell–dependent reprogramming of mononuclear phagocytes." Science Translational Medicine 13, no. 594 (2021): eabf5058. http://dx.doi.org/10.1126/scitranslmed.abf5058.

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Loss of major histocompatibility complex (MHC) class I and interferon-γ (IFN-γ) sensing are major causes of primary and acquired resistance to checkpoint blockade immunotherapy. Thus, additional treatment options are needed for tumors that lose expression of MHC class I. The cellular inhibitor of apoptosis proteins 1 and 2 (cIAP1/2) regulate classical and alternative nuclear factor κB (NF-κB) signaling. Induction of noncanonical NF-κB signaling with cIAP1/2 antagonists mimics costimulatory signaling, augmenting antitumor immunity. We show that induction of noncanonical NF-κB signaling induces

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32

Waxham, M. N., J. Aronowski, S. A. Westgate, and P. T. Kelly. "Mutagenesis of Thr-286 in monomeric Ca2+/calmodulin-dependent protein kinase II eliminates Ca2+/calmodulin-independent activity." Proceedings of the National Academy of Sciences 87, no. 4 (1990): 1273–77. http://dx.doi.org/10.1073/pnas.87.4.1273.

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33

Meuser, S., and H. J. Pflüger. "Programmed cell death specifically eliminates one part of a locust pleuroaxillary muscle after the imaginal moult." Journal of Experimental Biology 201, no. 16 (1998): 2367–82. http://dx.doi.org/10.1242/jeb.201.16.2367.

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In the hemimetabolous insect Locusta migratoria, fundamental restructuring occurs at the transition from flightless nymph to flight-capable adult. This transition involves all components of the flight circuit, which is present but not used for flight in nymphs. The meso- and metathoracic pleuroaxillary muscles, M85 and M114 respectively, constitute one component of this circuit. In the adult locust, these are flight-steering muscles, but their function in the nymph is as yet unknown. Our study reveals that adult and nymphal metathoracic pleuroaxillary muscles M114 differ profoundly. The nympha

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34

Cook, Erik P., and Daniel Johnston. "Voltage-Dependent Properties of Dendrites That Eliminate Location-Dependent Variability of Synaptic Input." Journal of Neurophysiology 81, no. 2 (1999): 535–43. http://dx.doi.org/10.1152/jn.1999.81.2.535.

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Voltage-dependent properties of dendrites that eliminate location-dependent variability of synaptic input. We examined the hypothesis that voltage-dependent properties of dendrites allow for the accurate transfer of synaptic information to the soma independent of synapse location. This hypothesis is motivated by experimental evidence that dendrites contain a complex array of voltage-gated channels. How these channels affect synaptic integration is unknown. One hypothesized role for dendritic voltage-gated channels is to counteract passive cable properties, rendering all synapses electrotonical

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35

SOLENG, A., A. B. S. POLÉO, N. E. W. ALSTAD, and T. A. BAKKE. "Aqueous aluminium eliminates Gyrodactylus salaris (Platyhelminthes, Monogenea) infections in Atlantic salmon." Parasitology 119, no. 1 (1999): 19–25. http://dx.doi.org/10.1017/s0031182099004436.

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This study focuses on the effect of acidic water and aqueous aluminium on the monogenean ectoparasite Gyrodactylus salaris, infecting Atlantic salmon (Salmo salar) parr. G. salaris-infected salmon were exposed to various combinations of acidity and aluminium concentrations. The most pronounced effect was the elimination of parasites after 4 days when 202 μg Al/l was added to the water. The effect of aluminium was concentration dependent, but was relatively independent of pH (5·2, 5·6 and 5·9). At the lowest pH of 5·0 the effect of aluminium was enhanced. Acidic aluminium-poor water had no or m

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36

Diaz Rohena, Daisy Y., Andrew D. Mitchell, Jing Wang, et al. "Protein Degrader WH25244 Eliminates Venetoclax Resistance Factors: Mutant or Hyperphosphorylated BCL2, and BCL-XL." Blood 144, Supplement 1 (2024): 2786. https://doi.org/10.1182/blood-2024-208159.

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The apoptosis blockade in chronic lymphocytic leukemia (CLL) can be overcome clinically through inhibition of the anti-apoptotic protein BCL2 with venetoclax. However, emergence of venetoclax resistance is driven by heterogenous mechanisms. Among these, BCL2 mutations decrease the binding affinity of venetoclax; BCL2 hyperphosphorylation increases the anti-apoptotic function of BCL2 by strengthening its interactions with pro-apoptotic molecules; and upregulation of alternative anti-apoptotic proteins like BCL-XL and MCL1 cannot be overcome by venetoclax. Novel strategies to target venetoclax r

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37

Cramer, Robert A., Michael P. Gamcsik, Rhea M. Brooking, et al. "Disruption of a Nonribosomal Peptide Synthetase in Aspergillus fumigatus Eliminates Gliotoxin Production." Eukaryotic Cell 5, no. 6 (2006): 972–80. http://dx.doi.org/10.1128/ec.00049-06.

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ABSTRACT The fungal secondary metabolite gliotoxin produced by Aspergillus fumigatus has been hypothesized to be important in the development of invasive aspergillosis. In this study, we addressed this hypothesis by disrupting a nonribosomal peptide synthetase (NRPS) (encoded by gliP) predicted to be involved in gliotoxin production. Mutants with a disrupted gliP locus failed to produce gliotoxin, which confirmed the role of the NRPS encoded by gliP in gliotoxin biosynthesis. We found no morphological, developmental, or physiological defects in ΔgliP mutant strains. In addition, disruption of

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Zhang, Qi, Sajid Khan, Xuan Zhang, et al. "Targeting BCL-XL By Protac DT2216 Effectively Eliminates Leukemia Cells in T-ALL Pre-Clinical Models." Blood 134, Supplement_1 (2019): 3870. http://dx.doi.org/10.1182/blood-2019-124744.

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T-ALL is an aggressive hematologic malignancy arising from immature T-cell precursors. Previous studies identified dependence of T-ALL (with a notable exception of early T-cell precursor (ETP) ALL) on BCL-XL (Chonghaile, Cancer Discovery 2014; Khaw, Blood 2016). However, BCL-XL specific inhibitors exhibit on-target toxicity of thrombocytopenia, restricting the use in acute leukemias (Vogler, Blood 2011). DT2216, a novel BCL-XL specific proteolysis targeting chimera (PROTAC), targets BCL-XL to the Von Hippel-Lindau (VHL) E3 ligase, leading to BCL-XL ubiquitination and degradation selectively in

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Begley, M. R., B. N. Cox, and R. M. McMeeking. "Time-Dependent Crack Initiation and Growth in Ceramic Matrix Composites." Journal of Engineering for Gas Turbines and Power 120, no. 4 (1998): 808–12. http://dx.doi.org/10.1115/1.2818472.

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Matrix cracking in ceramic matrix composites with fine grained fibers at high temperatures will be governed by fiber creep, as relaxation of the fibers eliminates crack tip shielding. Using a time dependent bridging law that describes the effect of creeping fibers bridging a crack in an elastic matrix, crack growth initiation and history have been modeled. For a stationary crack, crack tip stress intensity factors as a function of time are presented to predict incubation times before subcritical crack growth. Two crack growth studies are reviewed: a constant velocity approximation for small-sc

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40

Chen, Jian, Christina Wheeler, Jing Wang, et al. "Abstract 4795: Conditionally active biologics eliminates senescence cells in cancer and aging." Cancer Research 83, no. 7_Supplement (2023): 4795. http://dx.doi.org/10.1158/1538-7445.am2023-4795.

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Abstract The aberrant accumulation of senescent cells in aged and cancerous tissue triggers inflammatory signaling through a senescence-associated secretory phenotype (SASP), promoting aging and tumor progression. Pharmacologically, clearing senescent cells has been shown to have promising effects against cancer and age-related pathologies in preclinical models as well as early human clinical trials. However, current senescent cell elimination strategies are focused on targets that do not distinguish between hyper-inflamed or SASP senescent cells versus relatively non-inflamed senescent cells.

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41

Kazanci, Nadide, and Feride Severcan. "Concentration Dependent Different Action of Tamoxifen on Membrane Fluidity." Bioscience Reports 27, no. 4-5 (2007): 247–55. http://dx.doi.org/10.1007/s10540-007-9050-3.

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Tamoxifen (TAM) is a non-steroidal antiestrogen drug, which is widely used to prevent and treat breast, liver, pancreas and brain cancers. The present work investigates, in detail, the concentration dependent behavior of TAM (varying from 1 mol% to 45 mol%) on membrane fluidity. The differential scanning calorimetry (DSC) studies showed that tamoxifen eliminates the pre-transition and decreases the main phase transition to lower temperatures. Using visible spectroscopy at 440 nm and Fourier transform infrared (FTIR) spectroscopy it was found that membrane dynamics decreases for 1 and 3 mol% ta

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42

Yeh, Frank, та Richard Aldrich. "Temperature-Dependent Heat Capacity (ΔC(T)) Modification of the Thermodynamic Framework for Thermotrp Channels Eliminates Predicted Dual Thermosensitivity". Biophysical Journal 116, № 3 (2019): 536a. http://dx.doi.org/10.1016/j.bpj.2018.11.2884.

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43

Zhao, Ting C., Ling Zhang, Jun T. Liu, and Tai L. Guo. "Disruption of Nox2 and TNFRp55/p75 eliminates cardioprotection induced by anisomycin." American Journal of Physiology-Heart and Circulatory Physiology 303, no. 10 (2012): H1263—H1272. http://dx.doi.org/10.1152/ajpheart.00306.2012.

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Transient activation of p38 through anisomycin is demonstrated to precondition the heart against myocardial injury. However, it remains unknown whether specific TNF-α receptor (TNFR) p55/p75 and Nox2, a subunit of NADPH oxidase, are involved in this event. We sought to investigate whether the genetic disruption of TNFRp55/p75 and Nox2 eliminated cardioprotection elicited by anisomycin and whether p38-dependent activation of Nox2 stimulated TNFR to ultimately achieve protective effects. Adult wild-type and TNFR p55/p75−/−and Nox2−/−mice received intraperitoneal injections of anisomycin (0.1 mg/

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Razygraev, A. V. "Catalytic activity in rat blood plasma and erythrocytes that eliminates homocysteine with hydrogen peroxide." Biomeditsinskaya Khimiya 58, no. 5 (2012): 592–98. http://dx.doi.org/10.18097/pbmc20125805592.

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The activity utilizing the free SH-form of homocysteine with H2O2 has been found in rat blood plasma and erythrocyte lysates with the use of the glutathione peroxidase assay with hydrogen peroxide and 5,5'-dithiobis-(2-nitrobenzoic acid) and with the substitution of glutathione by homocysteine. The presence of rat plasma or erythrocyte lysate in a reaction mixture containing D,L-homocysteine, and H2O2 resulted in a marked acceleration of homocysteine concentration decrease (the decrease of homocysteine concentration was initiated by addition of hydrogen peroxide). The data obtained suggest the

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Delplanque, Emilie, Antoine Aymard, Davy Dalmas, and Julien Scheibert. "Solving curing-protocol-dependent shape errors in PDMS replication." Journal of Micromechanics and Microengineering 32, no. 4 (2022): 045006. http://dx.doi.org/10.1088/1361-6439/ac56ea.

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Abstract PolyDiMethylSiloxane (PDMS) is an elastomer increasingly used to produce soft objects by replication, in a variety of fields including soft electronics, microfluidics, tribology, biomechanics and soft robotics. While PDMS replication is usually considered faithful at all scales, down to nanoscales, detailed quantitative comparisons between the geometric features of the mold and the replicated object are still required to further ground this commonly accepted view. Here, we show that the top surface of centimetric parallelepipedic PDMS blocks, molded on a rigid plate, deviates from its

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Popugaeva, E. A., N. I. Zernov, A. V. Veselovsky, V. V. Poroikov, D. M. Melentieva, and A. V. Bolshakova. "Benzopyran derivative penetrates the blood–brain barrier, eliminates synaptic deficiency and restores memory deficit in 5xFAD mice." Genes & Cells 18, no. 4 (2023): 716–19. http://dx.doi.org/10.17816/gc623269.

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Alzheimer’s disease (AD) is a neurodegenerative disease that primarily affects older individuals and is characterized by gradual memory loss. Effective drug therapy for the disease is currently lacking. The clinical study findings of the medicinal properties of amyloid-binding antibodies demonstrate a multifaceted and intricate pathogenic mechanism of AD. Consequently, there is a crucial necessity for the exploration of novel molecular targets that can be subjected to pharmacological intervention to impede the disease progression. The calcium hypothesis of AD posits that the pathogenesis of AD

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Shields, Ryan K., M. Hong Nguyen, Ellen G. Press, and Cornelius J. Clancy. "Five-Minute Exposure to Caspofungin Results in Prolonged Postantifungal Effects and Eliminates the Paradoxical Growth of Candida albicans." Antimicrobial Agents and Chemotherapy 55, no. 7 (2011): 3598–602. http://dx.doi.org/10.1128/aac.00095-11.

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ABSTRACTWe studied the impact of brief caspofungin exposures on postantifungal effects (PAFEs) and paradoxical effects for fiveCandida albicansisolates. In time-kill studies, caspofungin at 4× and 16× the MIC resulted in significant killing of all isolates. Caspofungin at 8 μg/ml resulted in lower levels of killing, and paradoxical effects were evident with 4 isolates. Caspofungin exposures of 5 to 60 min caused prolonged, concentration-dependent killing that approached or exceeded the results seen with time-kill experiments and eliminated paradoxical growth.

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Maier, Josef, and Rainer Schmid. "Inhibition of pteridine biosynthesis eliminates blue-light dependent stimulation of red-light saturated photosynthesis in Laminaria saccharina (L.) Lamouroux." Journal of Photochemistry and Photobiology B: Biology 38, no. 2-3 (1997): 274–78. http://dx.doi.org/10.1016/s1011-1344(96)07464-7.

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Naserelden, Shiraz, Norma Alias, Abdelrahamn Altigani, et al. "Enhancing block cipher diffusion: A mathematical approach to key-dependent mix column transformations." Edelweiss Applied Science and Technology 9, no. 5 (2025): 436–43. https://doi.org/10.55214/25768484.v9i5.6886.

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In this paper, we propose a novel key-dependent MixColumn transformation to enhance the diffusion properties of block ciphers, specifically within the AES framework. The proposed method introduces dynamic variation into the MixColumn step by extracting a pseudo-random value from the round key, which is used to perform cyclic permutations on the MixColumn coefficients. This leads to the construction of a round-dependent transformation matrix, mathematically defined and proven to maintain invertibility over GF(2⁸). We provide a formal mathematical representation of the proposed model and analyze

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Tchesnokov, Egor P., Calvin J. Gordon, Emma Woolner, et al. "Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action." Journal of Biological Chemistry 295, no. 47 (2020): 16156–65. http://dx.doi.org/10.1074/jbc.ac120.015720.

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Remdesivir (RDV) is a direct-acting antiviral agent that is used to treat patients with severe coronavirus disease 2019 (COVID-19). RDV targets the viral RNA-dependent RNA polymerase (RdRp) of severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2). We have previously shown that incorporation of the active triphosphate form of RDV (RDV-TP) at position i causes delayed chain termination at position i + 3. Here we demonstrate that the S861G mutation in RdRp eliminates chain termination, which confirms the existence of a steric clash between Ser-861 and the incorporated RDV-TP. With WT RdRp,

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