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Relevant bibliographies by topics / Depigmentant

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Academic literature on the topic 'Depigmentant'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Depigmentant"

1

Andrei, Felicia, Alexa Ersilia, Camelia Tulcan, and Anca Dragomirescu. "Chemical Composition and the Potential of Lavandula angustifolia L. Oil as a Skin Depigmentant." Records of Natural Products 12, no. 4 (January 24, 2018): 340–49. http://dx.doi.org/10.25135/rnp.36.17.10.061.

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Lajis, Ahmad. "A Zebrafish Embryo as an Animal Model for the Treatment of Hyperpigmentation in Cosmetic Dermatology Medicine." Medicina 54, no. 3 (May 25, 2018): 35. http://dx.doi.org/10.3390/medicina54030035.

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For years, clinical studies involving human volunteers and several known pre-clinical in vivo models (i.e., mice, guinea pigs) have demonstrated their reliability in evaluating the effectiveness of a number of depigmenting agents. Although these models have great advantages, they also suffer from several drawbacks, especially involving ethical issues regarding experimentation. At present, a new depigmenting model using zebrafish has been proposed and demonstrated. The application of this model for screening and studying the depigmenting activity of many bioactive compounds has been given great attention in genetics, medicinal chemistry and even the cosmetic industry. Depigmenting studies using this model have been recognized as noteworthy approaches to investigating the antimelanogenic activity of bioactive compounds in vivo. This article details the current knowledge of zebrafish pigmentation and its reliability as a model for the screening and development of depigmenting agents. Several methods to quantify the antimelanogenic activity of bioactive compounds in this model, such as phenotype-based screening, melanin content, tyrosinase inhibitory activity, other related proteins and transcription genes, are reviewed. Depigmenting activity of several bioactive compounds which have been reported towards this model are compared in terms of their molecular structure and possible mode of actions. This includes patented materials with regard to the application of zebrafish as a depigmenting model, in order to give an insight of its intellectual value. At the end of this article, some limitations are highlighted and several recommendations are suggested for improvement of future studies.

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Fabbrocini, G., V. De Vita, N. Fardella, F. Pastore, M. C. Annunziata, M. C. Mauriello, A. Monfrecola, and N. Cameli. "Skin Needling to Enhance Depigmenting Serum Penetration in the Treatment of Melasma." Plastic Surgery International 2011 (April 7, 2011): 1–7. http://dx.doi.org/10.1155/2011/158241.

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Melasma is a common hypermelanotic disorder affecting the facial area which has a considerable psychological impact on the patient. Managing melasma is a difficult challenge that requires long-term treatment with a number of topical agents, such as rucinol and sophora-alpha. Aims. We aim to compare the combined treatment of skin needling and depigmenting serum with that using depigmenting serum alone in the treatment of melasma, in order to evaluate the use of microneedles as a means to enhance the drug’s transdermal penetration. Methods. Twenty patients were treated with combined skin needling and depigmenting serum on one side of the face and with depigmenting serum alone on the other side. The outcome was evaluated periodically for up to two months using the Melasma Area Severity Index score and the Spectrocolorimeter X-Rite 968. Results. The side with combined treatment (skin needling + depigmenting serum) presented a statistically significant reduction in MASI score and luminosity index (L) levels compared to the side treated with depigmenting serum alone, and clinical symptoms were significantly improved. Conclusions. Our study suggests the potential use of combining skin needling with rucinol and sophora-alpha compounds to achieve better results in melasma treatment compared to rucinol and sophora-alpha alone.

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Lajis, Ahmad Firdaus B., Muhajir Hamid, and Arbakariya B. Ariff. "Depigmenting Effect of Kojic Acid Esters in Hyperpigmented B16F1 Melanoma Cells." Journal of Biomedicine and Biotechnology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/952452.

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The depigmenting effect of kojic acid esters synthesized by the esterification of kojic acid usingRhizomucor mieheiimmobilized lipase was investigated in B16F1 melanoma cells. The depigmenting effect of kojic acid and kojic acid esters was evaluated by the inhibitory effect of melanin formation and tyrosinase activity on alpha-stimulating hormone- (α-MSH-) induced melanin synthesis in B16F1 melanoma cells. The cellular tyrosinase inhibitory effect of kojic acid monooleate, kojic acid monolaurate, and kojic acid monopalmitate was found similar to kojic acid at nontoxic doses ranging from 1.95 to 62.5 μg/mL. However, kojic acid monopalmitate gave slightly higher inhibition to melanin formation compared to other inhibitors at doses ranging from 15.63 to 62.5 μg/mL. Kojic acid and kojic acid esters also show antioxidant activity that will enhance the depigmenting effect. The cytotoxicity of kojic acid esters in B16F1 melanoma cells was significantly lower than kojic acid at high doses, ranging from 125 and 500μg/mL. Since kojic acid esters have lower cytotoxic effect than kojic acid, it is suggested that kojic acid esters can be used as alternatives for a safe skin whitening agent and potential depigmenting agents to treat hyperpigmentation.

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Sato, Kazuomi, and Masaru Toriyama. "Depigmenting Effect of Catechins." Molecules 14, no. 11 (November 4, 2009): 4425–32. http://dx.doi.org/10.3390/molecules14114425.

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Lima, Larissa Lavorato, Rebeca Mól Lima, Annelisa Farah da Silva, Antônio Márcio Resende do Carmo, Adilson David da Silva, and Nádia Rezende Barbosa Raposo. "Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential." Scientific World Journal 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/274643.

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This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activityin vitro, by qualitative and quantitative steps. The results showed the analogCas being the most powerful tyrosinase inhibitor (IA50= 65.67 ± 0.60 μg/mL), followed by the analogsB,E,F,A, andD, respectively. The analogCpresented a tyrosinase inhibition potential better than natural resveratrol (P<0.001). The best depigmenting activity was provided by the presence of hydroxyl in the orthoposition on the second phenolic ring.

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Nudelman, A., Z. Ben-Ishai, M. Ruse, and J. Schamroth. "Skin-depigmenting prodrugs of hydroquinone." European Journal of Medicinal Chemistry 28, no. 2 (January 1993): 159–64. http://dx.doi.org/10.1016/0223-5234(93)90008-3.

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Indro, RM Norman Tri Kusumo. "KOMPARASI ELECTROSURGERY, ABRASIVE BUR DAN SCALPEL TECHNIQUE PADA DEPIGMENTASI GUSI DENGAN TEKNIK SPLIT MOUTH (Case Series)." Jurnal Ilmiah dan Teknologi Kedokteran Gigi 14, no. 1 (September 19, 2018): 20. http://dx.doi.org/10.32509/jitekgi.v14i1.640.

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Pendahuluan dan tujuan : pigmentasi gingiva merupakan keluhan estetik utama terutama orang Asia. Pigmentasi melanin disebabkan oleh berlebihnya granul melanin didalan lapisan epitelium gingiva. Senyum yang harmonis dipengaruhi tidak hanya dari bentuk, posisi ,warna dari gigi, akan tetapi gusi berpengaruh. Pigmentasi melanin bukan merupakan kelainan patologis dan tidak berbahaya, penanganan secara estetik dapat dilakukan dengan hasil yang sangat baik. Penatalaksanaan : kasus ini menjelaskan teknik split mouth pada prosedur depigmentasi dengan tiga teknik yang berbeda. Prosedur dengan pisau bedah,dan dengan mata bur. kedua teknik ini dinilai efektif untuk menangani kasus depigmentasi gingiva. Pengukuran komparasi akan diukur dari wound healing index and visual analog scale. Kesimpulan : teknik dengan pisau bedah merupakan teknik yang paling umum dan memberikan hasil yang baik, kelemahan teknik pisau bedah adalah waktu operasi yang cukup lama. Prosedur dengan bur merupakan teknik yang mulai sering digunakan, teknik ini tidak memakan waktu serta hasil maksimal. Kelemahan teknik ini membutuhkan presisi. Kasus ini akan membahas mengenai kekurangan dan kelebihan dari ketiga teknik tersebut dengan mempertahankan prosedur pisau bedah sebagai terapi gold standard untuk depigmentasi.

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Kim, Kyuri, YoonJung Huh, and Kyung-Min Lim. "Anti-Pigmentary Natural Compounds and Their Mode of Action." International Journal of Molecular Sciences 22, no. 12 (June 8, 2021): 6206. http://dx.doi.org/10.3390/ijms22126206.

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Hyper-activated melanocytes are the major cause of skin hyper-pigmentary disorders, such as freckles and melasma. Increasing efforts have been made to search for materials with depigmenting activity to develop functional cosmetics. As a result, numerous materials have been reported to have depigmenting activity but some of them are known to cause unwanted side effects. Consequently, anti-pigmentary natural compounds without concern of toxicity are in great demand. Virtually all sorts of natural sources have been investigated to find anti-pigmentary natural compounds. This review summarizes recently reported anti-pigmentary natural compounds and their mode of action from the ocean, plants, and bacteria.

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Malaspina, Paola, Erica Catellani, Bruno Burlando, Daniele Brignole, Laura Cornara, Miriam Bazzicalupo, Simona Candiani, et al. "Depigmenting potential of lichen extracts evaluated by in vitro and in vivo tests." PeerJ 8 (May 15, 2020): e9150. http://dx.doi.org/10.7717/peerj.9150.

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Melanin is the main pigment of human skin, playing the primary role of protection from ultraviolet radiation. Alteration of the melanin production may lead to hyperpigmentation diseases, with both aesthetic and health consequences. Thus, suppressors of melanogenesis are considered useful tools for medical and cosmetic treatments. A great interest is focused on natural sources, aimed at finding safe and quantitatively available depigmenting substances. Lichens are thought to be possible sources of this kind of compounds, as the occurrence of many phenolic molecules suggests possible effects on phenolase enzymes involved in melanin synthesis, like tyrosinase. In this work, we used four lichen species, Cetraria islandica Ach., Flavoparmelia caperata Hale, Letharia vulpina (L.) Hue, and Parmotrema perlatum (Hudson) M. Choisy, to obtain extracts in solvents of increasing polarity, viz. chloroform, chloroform-methanol, methanol, and water. Cell-free, tyrosinase inhibition experiments showed highest inhibition for L. vulpina methanol extract, followed by C. islandica chloroform-methanol one. Comparable results for depigmenting activities were observed by means of in vitro and in vivo systems, such as MeWo melanoma cells and zebrafish larvae. Our study provides first evidence of depigmenting effects of lichen extracts, from tyrosinase inhibition to cell and in vivo models, suggesting that L. vulpina and C. islandica extracts deserve to be further studied for developing skin-whitening products.

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Dissertations / Theses on the topic "Depigmentant"

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Verdun, Marie-Odile. "Etude de l'activite in vitro sur la tyrosinase de differentes molecules a proprietes depigmentantes." Strasbourg 1, 1989. http://www.theses.fr/1989STR15045.

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Holzmann, Stéphane. "Etude des molécules dépigmentantes et leur utilisation en dermo-cosmétique." Paris 5, 1991. http://www.theses.fr/1991PA05P069.

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Denys, Krystel. "Les agents dépigmentants." Toulouse 3, 1993. http://www.theses.fr/1993TOU32105.

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HAMED, SAJA H. "EFFICACY AND MECHANISM OF ACTION OF A NEW TYROSINASE INHIBITORY AGENT." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085566152.

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Campbell, Berenice. "Pheroid technology for the topical delivery of depigmenting agents transforming growth factor–ß1 and tumor necrosis factor–a / Berenice Campbell." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4739.

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Pigmentation disorders occur in multiple conditions (Hakozaki et al., 2006:105). Although many modalities of treatments are available, none are completely satisfactory (Briganti et al., 2003:101). Two cytokines normally present in the skin, transforming growth factor–beta1 (TGF–81) and tumour necrosis factor–alpha (TNF–9), have been shown to inhibit melanin synthesis (Martinez–Esparza, 2001:972). The stratum corneum has been commonly accepted as the main barrier to percutaneous absorption. Many techniques have been applied to overcome this barrier properties and to enhance penetration with varying success (Pellet et al., 1997:92). The objective of this study was to investigate the topical delivery of the above mentioned peptide drugs with aid of the Pheroid drug delivery system. Pheroid technology is a delivery system that promotes the absorption and increases the efficacy of dermatological, biological and oral medicines in various pharmacological groups (Grobler et al., 2008:4). Pheroid entraps drugs with high efficiency and delivers them with remarkable speed to target sites (Grobler, 2004:4). In order to avoid degradation of these peptides, bestatin hydrochloride (an aminopeptidase inhibitor), was used (Lkhagvaa et al., 2008:386). Topical drug delivery was achieved by means of vertical Franz cell diffusion studies performed over a 6 and 12 h period. ELISA (enzyme linked immunosorbent assay) detection was used to detect cytokine concentrations. Entrapped cytokine solutions were monitored by confocal laser scanning microscopy (CLSM). Upon removal of donor and receptor compartments, skin discs were subjected to tape stripping in order to establish the amount of active present within the stratum corneum and epidermis as well as the remaining dermis (Pellet et al., 1997:92). When comparing the two studies with each other, it is evident that the diffused concentration values obtained with PBS (phosphate buffer solution, pH 7.4) was lower than that obtained with the Pheroid drug delivery system. Both cytokine concentrations were successfully delivered topically as a minimum of concentrations for both actives were detected. This positive result was confirmed as well by the amount of active detected in stratum corneum–epidermis and epidermis–dermis solutions.
Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2011.

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6

Krambeck, Karolline. "Nanostructured systems containing Passiflora edulis extract: A new dermocosmetic alternative as skin antioxidant and depigmentant." Tese, 2021. https://hdl.handle.net/10216/133656.

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Krambeck, Karolline. "Nanostructured systems containing Passiflora edulis extract: A new dermocosmetic alternative as skin antioxidant and depigmentant." Doctoral thesis, 2021. https://hdl.handle.net/10216/133656.

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Wei, Wang-Li, and 王立維. "In Vitro and In Vivo Studies Disclosed the Depigmenting Effects of Pt." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/hpp529.

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Chen, Mei-Jun, and 陳美均. "ZER inhibits UVA-induced Melanogenesis : Studies Disclosed the Depigmenting Effects of ZER." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/wvq9x7.

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Kuo, Shiou-yi, and 郭秀怡. "Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum Officinale." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/54639328720607757657.

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碩士
國立臺南大學
生物科技學系碩士班
100
Melanogenesis inhibition by raspberry ketone (RK) from Rheum officinale was investigated both in vitro in cultivated murine B16 melanoma cells and in vivo in zebrafish and mice. In B16 cells, RK inhibited melanogenesis through a post-transcriptional regulation of tyrosinase gene expression, which resulted in down regulation of both cellular tyrosinase activity and the amount of tyrosinase protein, while the level of tyrosinase mRNA transcription was not affected. In zebrafish, RK also inhibited melanogenesis by reduction of tyrosinase activity. In mice, application of a 0.2% or 2% gel preparation of RK applied to mouse skin significantly increased the degree of skin whitening within one week of treatment. In contrast to the widely used flavoring properties of RK in perfumery and cosmetics, the skin-whitening potency of RK has been demonstrated in the present study. Based on our findings reported here, RK would appear to have high potential for use in the cosmetics industry.

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Books on the topic "Depigmentant"

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(Editor), William J. Cunliffe, B. Dreno (Editor), H. Gollnick (Editor), and J. H. Saurat (Editor), eds. Ralga - The First Association Of Retinaldehyde And Glycolic Acid: A New Compound For The Acne Patient With Depigmenting Propertiessatellite Symposium Held ... Barcelona, October 2003 (Dermatology 2005). Not Avail, 2005.

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Book chapters on the topic "Depigmentant"

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Aljamal, Abdulrahman, Mohammed Aljamal, Sanjeev Mulekar, and Aleissa Ahmed. "Depigmenting Therapies." In Vitiligo, 399–409. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-62960-5_37.

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Galappatthy, Priyadarshani, and Deepani Rathnayake. "Depigmenting Agents." In Pigmentary Skin Disorders, 261–80. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-70419-7_18.

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Kumari, Rashmi. "Depigmenting Agents." In Comprehensive Textbook on Vitiligo, 187–93. First edition. | Boca Raton, FL : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9781315112183-35.

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Picardo, Mauro, and Maria Lucia Dell'Anna. "Depigmenting Agents." In Vitiligo, 439–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-69361-1_52.

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Dwivedi, Mitesh, Naresh C. Laddha, Anthony P. Weetman, Rasheedunnisa Begum, and Helen Kemp. "Vitiligo – A Complex Autoimmune Skin Depigmenting Disease." In Autoimmunity - Pathogenesis, Clinical Aspects and Therapy of Specific Autoimmune Diseases. InTech, 2015. http://dx.doi.org/10.5772/59762.

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