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Journal articles on the topic 'Depigmenting disorder'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Fabbrocini, G., V. De Vita, N. Fardella, et al. "Skin Needling to Enhance Depigmenting Serum Penetration in the Treatment of Melasma." Plastic Surgery International 2011 (April 7, 2011): 1–7. http://dx.doi.org/10.1155/2011/158241.

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Melasma is a common hypermelanotic disorder affecting the facial area which has a considerable psychological impact on the patient. Managing melasma is a difficult challenge that requires long-term treatment with a number of topical agents, such as rucinol and sophora-alpha. Aims. We aim to compare the combined treatment of skin needling and depigmenting serum with that using depigmenting serum alone in the treatment of melasma, in order to evaluate the use of microneedles as a means to enhance the drug’s transdermal penetration. Methods. Twenty patients were treated with combined skin needlin

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Kandhari, Sanjeev, P. Narasimha Rao, Shehnaz Arsiwala, Anil Ganjoo, Seema Sood, and Dinesh Kumar. "Expert opinion on current trends in hyperpigmentation management: Indian perspective." International Journal of Research in Dermatology 8, no. 1 (2021): 142. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20214925.

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<p class="abstract">Hyperpigmentation is a common pigmentary disorder characterized by increased production of melanin. It is present in Asian skin phototypes, with a higher prevalence in the Indian population. Skin heterogeneity is seen in more than 80% of individuals of all age groups and genders in several cities across India. In children, the prevalence of hyperpigmentary disorders accounts for 1.54 per 1000 children.Sixty expert dermatologists participated in expert group meetings via teleconference webinar to elaborate on the current trends in the management of hyperpigmentary diso

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Mahmood, Farhan, and Renée A. Beach. "Can it make me white again? A case report of 88% phenol as a depigmenting agent in vitiligo." SAGE Open Medical Case Reports 9 (January 2021): 2050313X2199330. http://dx.doi.org/10.1177/2050313x21993307.

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Vitiligo is the most common depigmenting disorder. However, therapies prove to be time-consuming, costly, or slow to show efficacy. Here, we present a case of a 74-year-old female with vitiligo who underwent full-body depigmentation treatment 50 years ago. Brown patches of repigmentation appeared on the patient’s face and arms and were eventually treated with 88% phenol. Patient was later switched to compounded 3% glutathione cream for a more sustained effect. Phenol was an accessible, economical, and easily administrable therapeutic option that can result in short-term depigmentation.

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Bagherani, Nooshin. "The Newest Hypothesis about Vitiligo: Most of the Suggested Pathogeneses of Vitiligo Can Be Attributed to Lack of One Factor, Zinc-α2-Glycoprotein". ISRN Dermatology 2012 (19 червня 2012): 1–8. http://dx.doi.org/10.5402/2012/405268.

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Zinc-α2-glycoprotein (ZAG) is a recently identified adipokine, assigned to the chromosome 7q22.1. It is a multidisciplinary protein, which is secreted in various body fluids. The ZAG plays roles in lipolysis, regulation of metabolism, cell proliferation and differentiation, regulation of melanin synthesis, cell adhesion, immunoregulation, and so forth. Vitiligo is the most common depigmenting skin disorder, characterized by acquired, progressive, and circumscribed amelanosis of the skin and hair. It commonly begins in childhood or young adulthood. The pathogenesis of this disorder is uncertain

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Kemp, E. Helen, Elizabeth A. Waterman, and Anthony P. Weetman. "Immunological pathomechanisms in vitiligo." Expert Reviews in Molecular Medicine 3, no. 20 (2001): 1–22. http://dx.doi.org/10.1017/s1462399401003362.

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Vitiligo is a depigmenting disorder characterised by the loss of melanocytes from the cutaneous epidermis. Although the exact aetiology of vitiligo has not yet been established, the abnormal immune responses frequently observed in vitiligo patients have led to the suggestion that, in some cases, the condition has an autoimmune component. Briefly, circulating autoantibodies and autoreactive T cells that recognise pigment cell antigens have been detected in the sera of a significant proportion of vitiligo patients compared with healthy individuals. In addition, vitiligo is often associated with

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J. Patel, Dharaben, Nehabahen T. Solanki, Dhwaniben R. Makwana, and Kirti S. Parmar. "A STUDY OF CORRELATION BETWEEN THYROID FUNCTION TEST ABNORMALITIES AND TYPES OF VITILIGO." International Journal of Advanced Research 10, no. 12 (2022): 779–83. http://dx.doi.org/10.21474/ijar01/15903.

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Background: Vitiligo is a chronic depigmenting disorder of skin and mucosal membrane which can be associated with many autoimmune cutaneous as well as systemic disorders. Association of vitiligo with various thyroid disorders has been implicated in various studies. Objectives: To evaluate the correlation of thyroid function test abnormalities in various types of vitiligo. Method: This is a case control study in which 82 cases of vitiligo and same number of age group and gender matched controls were enrolled. All patients including cases and controls were subjected to thyroid function tests (T3

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Gavalas, Nikos G., Samia Akhtar, David J. Gawkrodger, Philip F. Watson, Anthony P. Weetman, and E. Helen Kemp. "Analysis of allelic variants in the catalase gene in patients with the skin depigmenting disorder vitiligo." Biochemical and Biophysical Research Communications 345, no. 4 (2006): 1586–91. http://dx.doi.org/10.1016/j.bbrc.2006.05.063.

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Iwanowski, Tomasz, Karol Kołkowski, Roman Janusz Nowicki, and Małgorzata Sokołowska-Wojdyło. "Etiopathogenesis and Emerging Methods for Treatment of Vitiligo." International Journal of Molecular Sciences 24, no. 11 (2023): 9749. http://dx.doi.org/10.3390/ijms24119749.

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Vitiligo is an acquired chronic depigmenting disorder of skin. It is mostly asymptomatic and characterized by amelanotic macules and patches that affects 0.5% to 2% of the world’s population. The etiology of vitiligo has not been clearly elucidated and multiple theories have been proposed regarding the causes of the disorder. Among the most prevalent theories, the genetic predisposition, oxidative stress theory, promotion of cellular stress and pathologic influence of lymphocytes T have been highlighted. As a result of increases in in-depth knowledge concerning the pathogenetic processes in vi

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Furune, Satoshi, Chiaki Kondo, Yuko Takano, et al. "Vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment." International Cancer Conference Journal 11, no. 1 (2021): 46–48. http://dx.doi.org/10.1007/s13691-021-00515-w.

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AbstractVitiligo, an acquired depigmenting disorder of the skin that reacts against normal melanocytes, sometimes occurs as an immune-related adverse event in the treatment of melanoma with immune checkpoint inhibitors. It has been known that the occurrence of vitiligo is associated with a favorable therapeutic response in patients with melanoma, but it is not yet clear whether the association also applies to amelanotic melanoma, a minor subtype of melanoma with little or no melanin pigmentation. We report a patient with amelanotic melanoma of the esophagus who responded well to nivolumab trea

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Amornsiripanitch, S., L. M. Barnes, J. J. Nordlund, L. S. Trinkle, and L. A. Rheins. "Immune studies in the depigmenting C57BL/Ler-vit/vit mice. An apparent isolated loss of contact hypersensitivity." Journal of Immunology 140, no. 10 (1988): 3438–45. http://dx.doi.org/10.4049/jimmunol.140.10.3438.

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Abstract Vitiligo is a human disorder which destroys pigment cells in the skin, ears, eyes, and meningeal tissues and has often been associated with a variety of autoimmune disorders. The C57BL/Ler-vit/vit mouse is a mutant strain that exhibits a loss of epidermal pigment cells and a selective cell-mediated immune deficiency to epicutaneous-administered allergens. This observation is consistent with that observed in humans with vitiligo, who also exhibit loss of contact hypersensitivity (CHS), that appears to be associated with loss of pigment cells from the epidermis. Other cellular immune pa

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Abudureyimu, Miernisha, Deng Zang, Ainiwaer Talifu, Weiliang Zhu, and Haji Akber Aisa. "Discovery of small-molecule modulators of melanogenesis by docking-based virtual screening." Future Medicinal Chemistry 14, no. 4 (2022): 221–31. http://dx.doi.org/10.4155/fmc-2021-0150.

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Background: Vitiligo is a relatively common depigmenting skin disorder. UV light stimulation is often used to obtain repigmentation. Wnt signaling regulates melanocyte differentiation, and expression of TYR is upregulated in narrow-band UVB-treated epidermis. Manipulation of these two pathways by drugs could serve as one of the therapeutic approaches for durable repigmentation. Methods & results: CD9 was identified as a novel TYR activator by virtual screening and bioactivity assay. CD9 activated the Wnt signaling pathway through triggering translocation of β-catenin from cytoplasm to nucl

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Bergqvist, Christina, and Khaled Ezzedine. "Vitiligo: A Review." Dermatology 236, no. 6 (2020): 571–92. http://dx.doi.org/10.1159/000506103.

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Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5–2% of the population worldwide. The disease is characterized by the selective loss of melanocytes which results in typical nonscaly, chalky-white macules. In recent years, considerable progress has been made in our understanding of the pathogenesis of vitiligo which is now clearly classified as an autoimmune disease. Vitiligo is often dismissed as a cosmetic problem, although its effects can be psychologically devastating, often with a considerable burden on daily life. In 2011, an international consensus classif

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AlAfeefi, Mariam, and Shaden Abdelhadi. "Chemical Leukoderma or Vitiligo – Where Do We Draw the Line? A Case Report." Case Reports in Dermatology 16, no. 1 (2024): 198–201. http://dx.doi.org/10.1159/000539907.

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Introduction: Vitiligo is a skin depigmenting disorder influenced by both genetic and environmental factors. In contrast, chemical leukoderma (CL) is an acquired form of depigmentation caused by repeated exposure to specific chemical compounds. There is growing evidence of a similar pathogenesis in both entities; however in some cases, it remains unclear. Case Presentation: We present a case of a 26-year-old female who developed widespread depigmentation after using “lightning creams” containing Monobenzyl Ether Hydroquinone purchased online. The lesions displayed various tones of skin color,

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Choi, Chong Won. "Non-surgical treatment of vitiligo." Journal of the Korean Medical Association 63, no. 12 (2020): 741–47. http://dx.doi.org/10.5124/jkma.2020.63.12.741.

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Vitiligo is an acquired depigmenting skin disorder that affects 0.5% to 2% of the population. Skin lesions from vitiligo, white macules and patches on the skin, can pose a substantial psychological burdencan, causing a significant decrease in one’s quality of life. Recent basic and clinical studies have found that vitiligo is an autoimmune disorder, mediated by CD8+ T-cell and interferon-γ-mediated cytokine/chemokines. Although no treatment modality presents a complete cure for vitiligo, current treatment modalities have a modest effect on vitiligo by reversing the disease’s progression, induc

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Saikarthik, Prodduturu, Vesam Harinath Reddy, Shaik Mahammed Rafi, Valluru Wazeed Basha, and Somanaboina Padmakar. "A Systematic Review on Prevalence and Assessment of Sexual Dysfunction in Vitiligo." Journal of the Association of Physicians of India 70, no. 10 (2022): 64–67. http://dx.doi.org/10.5005/japi-11001-0116.

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Objective: Vitiligo is a common depigmenting disorder with significant psychosocial consequences. Vitiligo has been associated with psychological disorders such as depression, low self-esteem, anxiety, and sexual dysfunction (SD). In recent years, there is an increase in the number of studies looking into the impact of vitiligo on sexual functions. This systematic review investigates the assessment and prevalence of SD in vitiligo patients. Materials and methods: We carried out a systematic search for observational studies on the prevalence of SD in vitiligo patients. The Preferred Reporting I

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Jusuf, Nelva Karmila, Imam Budi Putra, and Dina Rizki Utami. "Quality of Life in Vitiligo Patients at H. Adam Malik General Hospital Medan, Indonesia." Sumatera Medical Journal 1, no. 1 (2018): 41–48. http://dx.doi.org/10.32734/sumej.v1i1.445.

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Abstract. Background: Vitiligo is an acquired depigmenting skin disorder that can affect the patients’ quality of life (QOL). Objectives: The aim of this study was to evaluate the QOL in patients with vitiligo. Methods: This study included 30 patients with vitiligo. All the patients filled out questionnaires Skindex- 29. Data were compiled and analyzed statistically. Results: Among the 30 vitiligo patients, 73,3 % were women and 26,7 % were men. Mean age of patients were 40.53 ± 12. 91 years old. The mean duration of vitiligo was 9.07 ± 7.643 years. The mean total Skindex-29 score of the subje

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Victor, Frank C., Jeremy Gelber, and Babar Rao. "Melasma: A Review." Journal of Cutaneous Medicine and Surgery 8, no. 2 (2004): 97–102. http://dx.doi.org/10.1177/120347540400800204.

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Objective: To better understand melasma, a review of its etiologic factors, classification, pathogenesis, and treatment was undertaken. Methods: Articles discussing the above aspects of melasma were used to demonstrate what is currently known about the disease and how to treat it. Results: Melasma is associated with many etiologic factors, most importantly, sun exposure. It occurs in three distributions and has four reported patterns of pigmentation. Among the many differences between melasma and normal skin, melasma skin contains increased melanin, melanocytes, and melanosomes, as well as inc

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Jusuf, Nelva Karmila, Imam budi Putra, and Dina rizki Utami. "QUALITY OF LIFE IN VITILIGO PATIENTS AT H. ADAM MALIK GENERAL HOSPITAL MEDAN, INDONESIA." Sumatera Medical Journal 1, no. 01 (2017): 25–30. http://dx.doi.org/10.32734/sumej.v1i01.79.

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Background: Vitiligo is an acquired depigmenting skin disorder that can affect the patients’ quality of life (QOL).Objectives: The aim of this study was to evaluate the QOL in patients with vitiligo.Patients and Methods: This study included 30 patients with vitiligo. All the patients filled out questionnaires Skindex- 29. Data were compiled and analyzed statistically.Results: Among the 30 vitiligo patients, 73,3 % were women and 26,7 % were men. Mean age of patients were 40.53 ± 12. 91 years old. The mean duration of vitiligo was 9.07 ± 7.643 years. Themean total Skindex-29 score of the subjec

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Pala, Valentina, Simone Ribero, Pietro Quaglino, and Luca Mastorino. "Updates on Potential Therapeutic Approaches for Vitiligo: Janus Kinase Inhibitors and Biologics." Journal of Clinical Medicine 12, no. 23 (2023): 7486. http://dx.doi.org/10.3390/jcm12237486.

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Vitiligo, the most prevalent skin depigmenting disease, is characterized by the selective loss of melanocytes, impacting patients’ quality of life significantly. This autoimmune disorder progresses through a complex interplay of genetic and non-genetic factors, posing challenges in comprehending its pathogenesis and devising effective treatment strategies for achieving remission. Existing conventional therapeutic approaches, such as topical and oral corticosteroids, calcineurin inhibitors, and phototherapy, lack specificity, offer modest efficacy, and may entail potential adverse effects. Cons

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Yash, Srivastav Akhandnath Prajapati Adityanath Prajapati Madhaw Kumar Mohammad Aqil Siddiqui. "A study of challenges and quality of life (QoL) issues related to Vitiligo disease's current treatments." Int. J. in Pharm. Sci. 1, no. 9 (2023): 17–30. https://doi.org/10.5281/zenodo.8312051.

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The appearance of white patches is a sign of the skin disorder vitiligo. Segmental vitiligo usually becomes dormant after two years of stabilization of the condition. Non-segmental vitiligo can reactivate even after extended periods of stability. Vitiligo is the most common depigmenting skin disorder, affecting 0.5–2% of people worldwide, including both adults and children. the hands, face, and areas close to bodily openings and the genitalia are frequent starting points. premature whitening or greying of your beard, eyebrows, or scalp hair. The mucous membranes, which line the inside of

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B., Rajitha* M. Chandrika Saniya Begum T. Thanvika R. Rohith G. Jagadeesh. "Vitiligo: A Comprehensive Review of Epidemiology, Cancer Relationand Emerging Treatments." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 3218–27. https://doi.org/10.5281/zenodo.14562904.

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Vitiligo is a persistent depigmenting skin disorder marked by the appearance of white patches on the skin, caused by the loss of Melanocytes. It affects around 0.5-1℅ of the global population, regardless of age, gender or race. Although vitiligo is not lethal or life-threatening, it does carry a social stigma that lowers self-esteem in people affected. Recent research suggests that vitiligo is a primary autoimmune illness in which the body's immune system destroys pigment-producing cells, Melanocytes, resulting in depigmentation. Additionally, oxidative stress and genetic predisposition mechan

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Sesia Pradestine, Muhammad Eko Irawanto, Osdatilla Esa Putri, Trya Oktaviani, and Benedicta Lauda Anandita. "Unveiling the Hidden Patterns: A Dermoscopic Analysis of Vitiligo Lesions at a Tertiary Care Center in Surakarta, Indonesia." Bioscientia Medicina : Journal of Biomedicine and Translational Research 9, no. 4 (2025): 7076–89. https://doi.org/10.37275/bsm.v9i4.1258.

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Background: Vitiligo, a common depigmenting disorder, presents with a variety of clinical manifestations. Dermoscopy, a non-invasive skin imaging technique, has emerged as a valuable tool for evaluating pigmentary disorders. This study aimed to analyze the dermoscopic patterns of vitiligo lesions in a cohort of patients at a tertiary care center in Surakarta, Indonesia, and to correlate these patterns with disease stability. Methods: This cross-sectional study included 20 adult patients diagnosed with vitiligo at the Dermatology and Venereology Outpatient Clinic of Dr. Moewardi Regional Genera

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Relke, Nicole, and Melinda Gooderham. "The Use of Janus Kinase Inhibitors in Vitiligo: A Review of the Literature." Journal of Cutaneous Medicine and Surgery 23, no. 3 (2019): 298–306. http://dx.doi.org/10.1177/1203475419833609.

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Vitiligo is a common acquired depigmenting disorder characterized by the development of white macules and patches due to the loss of melanocytes. Patients with vitiligo can be stigmatized by society, making the disease a source of psychological stress that can considerably affect quality of life. The goal of vitiligo treatment is to obtain skin repigmentation in the majority of cases, and less commonly to depigment the remaining normal skin. There is no consistent, long-term, durable therapy for vitiligo for all patients, highlighting the unmet need for new safe and effective therapies to cont

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Mohamed, Mohamed Ashraf Elsaid, Lamia Hamouda Elgarhy, Ayman Mohamed Elsaka, Marwa Elsamongy, and Samia Othman Nassar. "Vitiligo: Highlights on Pathogenesis, Clinical Presentation and Treatment." Journal of Advances in Medicine and Medical Research 35, no. 19 (2023): 165–87. http://dx.doi.org/10.9734/jammr/2023/v35i195151.

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Vitiligo is a common acquired skin depigmentation that affects people of all races, but is significantly more disfiguring in black individuals. The exact cause of vitiligo is unknown. It is believed that an autoimmune process targeting melanocytes mediates its pathogenesis. In accordance with this hypothesis, histopathological examinations of vitiliginous skin have revealed the absence of melanocytes. Multiple autoantibodies against melanocyte antigens, including various enzymes and other substances, have been detected in the sera of some vitiligo patients. Twenty to thirty percent of pa

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Zilles, Júlia Capp, Larissa Pedron Duarte, Thaís Carine Ruaro, Aline Rigon Zimmer, Irene Clemes Kulkamp-Guerreiro, and Renata Vidor Contri. "Nanoemulsion Containing Kojic Dipalmitate and Rosehip Oil: A Promising Formulation to Treat Melasma." Pharmaceutics 15, no. 2 (2023): 468. http://dx.doi.org/10.3390/pharmaceutics15020468.

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Melasma is a hard-to-treat hyperpigmentation disorder. Combined incorporation of kojic dipalmitate (KDP), the esterified form of kojic acid, and rosehip oil, an oil with antioxidant and skin-regenerating properties, into nanocarrier systems appears to be a suitable strategy to develop high-performance formulations. A high-energy method (Ultra-Turrax®) was used to develop nanoemulsions containing up to 2 mg/mL KDP, 5% rosehip oil, and 7.5% surfactant. Formulations were characterized regarding droplet size, size distribution, pH, density, morphology, KDP content, incorporation efficiency, and st

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Iqbal, Sameera, Uzma Amin, Ashba Nasir Cheema, Adnan Ali Salim, Saadoon Ali, and Muhammad Azam Bukhari. "The Efficacy of Therapeutic Needling with Narrow-Band UVB in Patients of Stable Vitiligo." Journal of University College of Medicine and Dentistry 2, no. 2 (2023): 51–54. http://dx.doi.org/10.51846/jucmd.v2i2.2496.

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Objective: To determine the efficacy of therapeutic needling with narrow-band UVB in patients of stable vitiligo with type IV skin, which is the most common depigmenting skin disorder, characterized by clearly demarcated discolored patches of various shapes and sizes.Methodology: This descriptive case series was conducted on one hundred dermal skin patches of stable vitiligo in 20 patients presenting to the outdoor of Dermatology Department, Services Hospital Lahore from January- June 2019. They were subjected to therapeutic needling using 30 G disposable insulin syringe followed immediately b

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Fauzia, Sarah, Rahmadewi Rahmadewi, and Dyah Fauziah. "CLINICAL PROFILES OF VITILIGO WITH NARROWBAND UVB AND TOPICAL CORTICOSTEROID THERAPY AT DR. SOETOMO HOSPITAL." Jurnal Berkala Epidemiologi 8, no. 1 (2020): 8. http://dx.doi.org/10.20473/jbe.v8i12020.8-15.

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Background: Vitiligo is a depigmenting disorder that causes a loss of melanocytes in the epidermis. Treatment preferences are based on the characteristics of the vitiligo lesions. Purpose: This study evaluates the clinical profiles of vitiligo treated with narrowband UVB (NB-UVB) and topical corticosteroid therapy in Dr. Soetomo Hospital in 2017. Methods: This study is a retrospective study that uses data from the medical records of vitiligo patients who were treated with NB-UVB and topical corticosteroids in Dr. Soetomo Hospital in 2017. The dependent variable was vitiligo treated with NB-UVB

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Youssef, Randa, Nourhan Emad, Olfat Shaker, and Rania M. Mogawer. "The effect of narrowband ultraviolet B on tissue level of interleukin-15 and interleukin-15 receptor alpha subunit in active nonsegmental vitiligo cases: an interventional cohort study." Journal of the Egyptian Women's Dermatologic Society 21, no. 2 (2024): 120–26. http://dx.doi.org/10.4103/jewd.jewd_77_23.

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Background Vitiligo is an acquired depigmenting skin disorder in which CD8 effector and memory T-cells contribute to its pathogenesis and recurrence. Interleukin (IL)-15 contributes to CD8 effector T-cell cytotoxicity and CD8 memory T-cell survival and maturation. Objective To evaluate the effect of total narrowband ultraviolet B (NB-UVB) on tissue levels of IL-15 and IL-15 receptor alpha (IL-15Ra) in active nonsegmental vitiligo. Patients and methods The patients were assessed clinically for vitiligo extent and activity before and after treatment. Perilesional skin biopsies were taken from 30

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Rina Gustia and Redha Cipta Utama. "The Impact of COVID-19 Pandemic on Vitiligo Patient Visits in Tertiary Hospital: A Retrospective Study." Bioscientia Medicina : Journal of Biomedicine and Translational Research 8, no. 5 (2024): 4394–400. http://dx.doi.org/10.37275/bsm.v8i5.992.

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Background: Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5–2% of the population worldwide. The COVID-19 pandemic lockdown measures significantly affected the readiness of vitiligo patients to contact dermatologists. The aim of this study is to describe vitiligo patient visits during a pandemic situation. Methods: A retrospective descriptive study, using secondary data obtained from Dr. M. Djamil General Hospital Padang medical records during the period of 2019–2021. Results: During the pandemic (2020-2021), a total of 7 in 2020 and 19 in 2021 new

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Lumbantoruan, Erty Witalaya, Khairina Nasution, and Nelva Karmila Jusuf. "Combination Therapy in Melasma with Lentigo Solaris." Sumatera Medical Journal 3, no. 1 (2020): 65–70. http://dx.doi.org/10.32734/sumej.v3i1.690.

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Background: Melasma and lentigo solaris are common, recurrent, and refractory acquired hyperpigmentation disorder. In spite of variety of therapeutic options available for this cosmetically disfiguring condition, the treatment of this condition remains a challenge. Azelaic acid (AA) is a depigmenting agent which acts by inhibition of DNA synthesis and mitochondrial enzymes, thereby inducing direct cytotoxic effects on melanocytes. Glycolic acid (GA) peel is one of the most versatile agents in the treatment of melasma and lentigo solaris. GA peels alone or in combination with topical hypopigmen

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Kumar, P. Ravindra. "Study of vitiligo at a tertiary care hospital." MedPulse International Journal of Medicine 11, no. 2 (2021): 112–14. http://dx.doi.org/10.26611/102111211.

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Background: Vitiligo is a common acquired, progressive, multifactorial, depigmenting disorder characterized by the appearance of circumscribed white macules varying patterns, varying from small macules with scalloping borders to near total depigmentation of body, supposed to be due to chronic, progressive loss of functional melanocytes in the epidermis. This study was aimed to study vitiligo in our tertiary care hospital. Material and Methods: This prospective, observational and descriptive study was conducted in OPD patients clinically diagnosed as vitiligo during study period. Results: A tot

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Sarkar, Rashmi, Anjali Sahu, and Vibhu Mendiratta. "Efficacy and Safety of Cysteamine in Melasma in Patients of Skin of Colour: A Brief Report." Indian Dermatology Online Journal 16, no. 2 (2025): 276–79. https://doi.org/10.4103/idoj.idoj_616_24.

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Abstract Background: Melasma is a common disorder of pigmentation. Traditional treatments often come with limitations, prompting the need for alternative newer therapies. Cysteamine cream, a new topical depigmenting drug, has shown potential in treating melasma while maintaining a good safety profile. Aim: This case series aims to evaluate the efficacy and safety of cysteamine cream in treating melasma in patients of skin of colour (Fitzpatrick’s skin types III, IV, and V). Patients and Methods: Ten Indian women with Fitzpatrick skin types III–V with epidermal melasma diagnosed clinically and

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Dr, Sai Deepthi Yerrguntla. "A Retrospective Multivariate Analysis of Pre and Post Pubertal Onset of Vitiligo in a Tertiary Care Center." International Journal of Medical and Pharmaceutical Research 4, no. 6 (2023): 69–73. https://doi.org/10.5281/zenodo.10168605.

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<strong>Background</strong>: Vitiligo is an acquired, progressive depigmenting disorder that presents as depigmented macules or patches. Although it may manifest at any time in life, it usually begins in childhood. There is insufficient data to compare the clinical correlations of prepubertal and post-pubertal onset vitiligo.<strong>Objective</strong>: To compile the clinical profiles and sociodemographic parameters of vitiligo patients by the age of onset of vitiligo.<strong>Materials and Methods</strong>: Aretrospectivehospital-based study in a tertiary care hospital, the medical records of

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De Oliveira Andrade, Luis Jesuino, Gustavo Magno Baptista, Juliane Santos Dias, Alcina Maria Vinhaes Bittencourt, and Larissa Santos França. "Relationship between vitiligo and Hashimoto's thyroiditis." Revista de Ciências Médicas e Biológicas 16, no. 1 (2017): 5. http://dx.doi.org/10.9771/cmbio.v16i1.17619.

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<p><strong>Background</strong>: Vitiligo is a multifactorial acquired depigmenting disorder, characterized by a spontaneous loss of functional melanocytes from the epidermis. Vitiligo and Hashimoto's thyroiditis (HT) often occur in association and seem to be characterized by an autoimmune process. The vitiligo associated with HT suggests genetic homologies between them.</p><p><strong>Objective</strong>: To identify protein sequence homology between melanocyte protein (Pmel) and thyroid peroxidase (TPO), using bioinformatics tools, to propose an initial

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Tuyen, Nguyen Thi, Nguyen Van Doanh, and Nguyen Thi Mai Huong. "IMPACT OF VITILIGO ON QUALITY OF LIFE." Tạp chí Da liễu học Việt Nam 33 (June 16, 2022): 55–60. http://dx.doi.org/10.56320/tcdlhvn.v33i.66.

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Introduction and objective: Vitiligo is a chronic depigmenting disorder with profound psychological effects. This study aimed to assess the quality of life (QoL) of Vietnamese patients with vitiligo. Material and method: We conducted a cross-sectional study at the National Hospital of Dermatology and Venereology in Hanoi, Vietnam. 164 patients with vitiligo older than 6 years of age who attended the hospital from July 2018 to March 2019 were recruited. Data were collected using a structured questionnaire, 39 pediatric patients aged from 6 to 15 years were administered the Children’s Dermatolog

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Adhikari, Sabina, Sushil Karki, Anand Nepal, and Kathit Raj Ghimire. "A comparative study between the use of the combination of trichloroacetic acid peeling with hydroquinone and hydroquinone alone in patients with melasma." Asian Journal of Medical Sciences 14, no. 6 (2023): 119–24. http://dx.doi.org/10.3126/ajms.v14i6.51383.

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Background: Melasma is a common acquired pigmentary disorder that is aesthetically displeasing. Kligman’s and Modified Kligman’s formula using topical steroids, hydroquinone and retinoids, and various other depigmenting agents is being widely used all over for melasma with varying results. Chemical peeling is newly added to the therapeutic armamentarium and is showing encouraging results worldwide in patients with melasma. However, comparative studies are lacking in abundance in our part of the world. Aims and Objectives: To determine if serial trichloroacetic acid peels provide additional ben

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Maheshwari, Abhishek, Rajlaxmi Panigrahi, and Shruti Mahajan. "Vitiligo associated hypoacusis: a case control study." International Journal of Otorhinolaryngology and Head and Neck Surgery 2, no. 2 (2016): 77. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20160958.

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<p class="abstract"><strong>Background:</strong> Vitiligo is a progressive depigmenting cutaneous disorder, resulting from the loss of melanocytes. In the inner ear, melanocytes are believed to play an important role in development and normal functioning of stria vascularis. Acoustic abnormalities in vitiligo patients remain obscured for long durations. This study was carried out to determine the prevalence of subclinical sensorineural hearing loss in vitiligo patients, if any, in comparison with controls and to detect any relevant demographic or clinical finding characterist

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Glassman, Steven J. "Vitiligo, reactive oxygen species and T-cells." Clinical Science 120, no. 3 (2010): 99–120. http://dx.doi.org/10.1042/cs20090603.

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The acquired depigmenting disorder of vitiligo affects an estimated 1% of the world population and constitutes one of the commonest dermatoses. Although essentially asymptomatic, the psychosocial impact of vitiligo can be severe. The cause of vitiligo remains enigmatic, hampering efforts at successful therapy. The underlying pathogenesis of the pigment loss has, however, been clarified to some extent in recent years, offering the prospect of effective treatment, accurate prognosis and rational preventative strategies. Vitiligo occurs when functioning melanocytes disappear from the epidermis. A

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Grochocka, Małgorzata, Adam Wełniak, Aleksandra Białczyk, Luiza Marek-Jozefowicz, Tadeusz Tadrowski, and Rafał Czajkowski. "Management of Stable Vitiligo—A Review of the Surgical Approach." Journal of Clinical Medicine 12, no. 5 (2023): 1984. http://dx.doi.org/10.3390/jcm12051984.

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At present, vitiligo is the most common depigmenting skin disorder, characterized by clearly demarcated discolored patches of various shapes and sizes. Depigmentation results from the initial dysfunction and subsequent destruction of melanin-producing cells, called melanocytes, which are located in the basal layer of the epidermis and in hair follicles. This review concludes that the extent of repigmentation, regardless of the treatment method, is greatest in stable localized vitiligo patients. The aim of this review is to provide an overview of the clinical evidence for which the vitiligo tre

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Dr., Nirmalya Kumar Das, and Suchibrata Das Dr. "Evaluation of Some common clinical factors in extensive vitiligo- a case control study." Evaluation of Some common clinical factors in extensive vitiligo- a case control study 7, no. 6 (2019): 543–51. https://doi.org/10.17511/ijmrr.2019.i06.15.

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Introduction: Vitiligo is a common depigmenting disorder with profound stigma. Prevalence of vitiligo is 0.5% to 1%. Information about association of progressive vitiligo are well known. Prognostic factors of vitiligo also enlisted. However, little information is available on the risk factors for developing extensive vitiligo. Aims and Objectives: Aims of the study was to identify – factors which are associated with extensive vitiligo (involving more than 5% of the body surface area). The following risk factors were evaluated, Onset before 20 years of age, Duration of disease greater tha

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Parineeta, Maria, Bhardwaj Deep, and Gupta Bharat. "Clinico-Epidemiological Profile of Vitiligo among Children: A Prospective Study from Tertiary Care Hospital of Central India." International Journal of Pharmaceutical and Clinical Research 15, no. 6 (2023): 1866–71. https://doi.org/10.5281/zenodo.12521703.

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<strong>Background: </strong>Due to the loss of functioning melanocytes, vitiligo is a frequent acquired skin condition characterized by depigmented macules and patches. The stigma attached to vitiligo causes patients and their families to worry about how it may affect their appearance, which is one of the most significant features of the disease.In order to better understand the clinical pattern and systemic associations of childhood vitiligo in the central region of India, this study was conducted. <strong>Methods: </strong>The study included all vitiligo patients under the ag

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Srushti, Phadtare* Sakshi Yadav Vansh Wagh Pradyna Yadav Shreya Yadav Sanket Wankhede. "Herbal Depigmentation Cream." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 305–14. https://doi.org/10.5281/zenodo.15333304.

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Skin pigmentation disorders like hyperpigmentation, melasma, dark spots, and post-inflammatory pigmentation affect millions worldwide, often triggered by UV exposure, hormonal changes, inflammation, and aging. While conventional depigmenting agents like hydroquinone and kojic acid are effective, they can cause skin irritation and sensitivity, leading to a demand for safer alternatives. Herbal ingredients have gained attention for their natural skin-brightening and healing properties. Botanicals such as turmeric, aloe vera, licorice, alum, honey, vitamin E, glycerin, and rose water show po

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Azmat, Fareeha, Mehran Khan, Irfan Ullah Afridi, Soaiba Naeem, Hajira Amin, and Sara Pervez. "QUALITY OF LIFE IN PATIENTS WITH VITILIGO PRESENTING TO TERTIARY CARE HOSPITAL." Insights-Journal of Health and Rehabilitation 3, no. 2 (Health & Allied) (2025): 348–55. https://doi.org/10.71000/h08f4c13.

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Background: Vitiligo is a chronic depigmenting skin disorder characterized by the loss of melanocytes, resulting in progressive white patches that often carry psychological and social consequences. Although it poses no direct physical harm, vitiligo can significantly impair the quality of life (QoL), particularly when lesions are located on visible areas of the body. The emotional toll is often under-recognized, especially in resource-limited settings where psychosocial support may be lacking. Objective: To evaluate the quality of life (QoL) in patients with vitiligo presenting to a tertiary c

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Wu, Bing-Qi, Yen-Jen Wang, Chang-Cheng Chang, Tzong-Yuan Juang, Yung-Hsueh Huang, and Ying-Chuan Hsu. "Clinical Efficacy of Cysteamine Application for Melasma: A Meta-Analysis." Journal of Clinical Medicine 13, no. 23 (2024): 7483. https://doi.org/10.3390/jcm13237483.

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Background: Melasma is a challenging, acquired hyperpigmentary disorder. The gold standard treatment is Kligman’s formulation, which contains hydroquinone, tretinoin, and dexamethasone, but its long-term use is limited by the risk of exogenous ochronosis. Cysteamine, a tyrosinase inhibitor, reduces melanocyte activity and melanin production, showing strong depigmenting effects in patients resistant to Kligman’s formulation. Nonetheless, clinical studies have yielded inconsistent efficacy results. This meta-analysis aimed to assess the efficacy of cysteamine in treating melasma and to identify

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Kim, Kyuri, YoonJung Huh, and Kyung-Min Lim. "Anti-Pigmentary Natural Compounds and Their Mode of Action." International Journal of Molecular Sciences 22, no. 12 (2021): 6206. http://dx.doi.org/10.3390/ijms22126206.

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Hyper-activated melanocytes are the major cause of skin hyper-pigmentary disorders, such as freckles and melasma. Increasing efforts have been made to search for materials with depigmenting activity to develop functional cosmetics. As a result, numerous materials have been reported to have depigmenting activity but some of them are known to cause unwanted side effects. Consequently, anti-pigmentary natural compounds without concern of toxicity are in great demand. Virtually all sorts of natural sources have been investigated to find anti-pigmentary natural compounds. This review summarizes rec

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Pavic, Aleksandar, Tatjana Ilic-Tomic, and Jasmina Glamočlija. "Unravelling Anti-Melanogenic Potency of Edible Mushrooms Laetiporus sulphureus and Agaricus silvaticus In Vivo Using the Zebrafish Model." Journal of Fungi 7, no. 10 (2021): 834. http://dx.doi.org/10.3390/jof7100834.

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Severe drawbacks associated with the topical use of depigmenting agents in treatments of skin hyperigmentations impose a great demand for novel, effective, and safe melanogenesis inhibitors. Edible and medicinal mushrooms, known for numerous health-promoting properties, represent a rich reservoir of anti-melanogenic compounds, with the potential to be applied in preventing excessive skin pigmentation. Herein, using zebrafish (Danio rerio) as a preclinical animal model, we have demonstrated that ethanol extract of Laetiporus sulphureus (LSE) and Agaricus silvaticus (ASE) are not toxic at high d

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Kim, Jinhwan, Yo-Han Kim, Seunghyun Bang, et al. "L-765,314 Suppresses Melanin Synthesis by Regulating Tyrosinase Activity." Molecules 24, no. 4 (2019): 773. http://dx.doi.org/10.3390/molecules24040773.

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Although melanin production is a key self-defense mechanism against ultraviolet radiation (UVR)-induced skin damage, uneven or excessive deposition of melanin causes hyperpigmentary disorders. Currently available whitening agents are unsatisfactory because of issues with efficacy and safety. To develop more effective depigmenting agents, we performed high-throughput melanin content assay screening using the B16F10 melanoma cell line and identified L-765,314 as a drug that suppressed melanin production in cultured melanocytes in a dose-dependent manner as well as cAMP- or 12-O-tetradecanoylphor

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Malik, Shivani, Arun Kumar Yadav, Lalit Raj, Renu Singh, and Ashok Kumar Arya. "Oncologist-patient conflict regarding imatinib-induced pigmentation: A case report and literature review." National Journal of Pharmacology and Therapeutics 2, no. 2 (2024): 95–100. http://dx.doi.org/10.4103/njpt.njpt_6_24.

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Abstract: The tyrosine kinase inhibitor imatinib mesylate is well known for inhibiting melanocyte growth, which results in hypopigmentation, but here, we present a case report of imatinib-induced hyperpigmentation in a 42-year-old female belonging to a lower-middle socioeconomic status and a resident of a local village. The case report is unique as it provides valuable insights into clinical characteristics, diagnostic challenges, and therapeutic considerations for imatinib-induced hyperpigmentation which may contribute to existing literature on this rare and challenging entity, particularly i

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Boniface, K., A. Taieb, and J. Seneschal. "Cell delivery using microneedle devices: a new approach to treat depigmenting disorders." British Journal of Dermatology 178, no. 3 (2018): 588–89. http://dx.doi.org/10.1111/bjd.16159.

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Pandya, Amit G. "TONE: A Large, Prospective Post-Approval Study Investigating the Repigmentation of Stable Vitiligo Lesions Using a Point-of-Care Autologous Cell Harvesting Device." SKIN The Journal of Cutaneous Medicine 8, no. 6 (2024): s507. http://dx.doi.org/10.25251/skin.8.supp.507.

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Introduction: Vitiligo is a depigmenting autoimmune skin disorder caused by loss of melanocytes, impacting 0.5% to 2% of the global population.1-3 For patients with stable vitiligo, surgery allows for physical transplantation of healthy melanocytes to a lesion lacking functional melanocytes.1,4 A combination approach incorporating vitiligo surgery with pharmacotherapy may be recommended in some patients, as employing multiple modalities can improve repigmentation response.4 A point-of-care Autologous Cell Harvesting Device, FDA-approved for the repigmentation of stable vitiligo lesions, prepar

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