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Journal articles on the topic 'Depressant disorders'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Shevlin, Mark, Michael Rosato, Stephanie Boyle, Daniel Boduszek, and Jamie Murphy. "Rates and predictors of anti-depressant prescribing in Northern Ireland 2011–2015: a data linkage study using the Administrative Data Research Centre (NI)." Irish Journal of Psychological Medicine 37, no. 1 (2019): 32–38. http://dx.doi.org/10.1017/ipm.2019.14.

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Objectives:Research indicates that anti-depressant prescribing is higher in Northern Ireland (NI) than in the rest of the UK, and that socio-economic and area-level factors may contribute to this. The current study provides comprehensive population-based estimates of the prevalence of anti-depressant prescription prescribing in NI from 2011 to 2015, and examined the associations between socio-demographic, socio-economic, self-reported health and area-level factors and anti-depressant prescription.Methods:Data were derived from the 2011 NI Census (N = 1 588 355) and the Enhanced Prescribing Dat

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Pratiksha, Mhalsane* Dr. Gopal Bihani Dr. Pavan Folane Dr. Kailash Biyani. "Evaluation Of Antidepressant Activity of Passiflora Edulis in Laboratory Animals." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3943–49. https://doi.org/10.5281/zenodo.15498381.

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Passion fruit, Passiflora edulis, is a plant with numerous medicinal properties, including antidiabetic, anxiolytic, antineoplastic, antioxidant, analgesic, and anti-inflammatory properties. It is native to Brazil, Paraguay, and Argentina and is widely grown in South America, the Caribbean, South Florida, South Africa, and Asia. Passion fruit comes in two forms, standard yellow and standard yellow, with an annual production of about 120 tons. In Bhutan, it is grown in purple and yellow varieties, with the purple variety being the most commonly grown. Passion fruit grows on various soil types a

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DuPont, Robert L., and Keith E. Saylor. "Depressant Substances in Adolescent Medicine." Pediatrics In Review 13, no. 10 (1992): 381–86. http://dx.doi.org/10.1542/pir.13.10.381.

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The benzodiazepines have replaced widespread use of barbiturates and other sedatives. They are effective, safe medicines used to treat a variety of disorders associated with excessive CNS excitability. Although many physicians avoid prescribing benzodiazepines to adolescents, there is little evidence to support this practice. Unless an adolescent has a history of substance abuse/dependence and suicidal ideation, the benzodiazepines are safe. Benzodiazepine toxicity rarely occurs unless another CNS depressant, especially alcohol, is used concurrently.

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Razvi, Ummehani A., and Laxmikant H. Kamble. "Identification of Serotonin Transporter Inhibitors from Selected Marine Alkaloids: A Molecular Docking and ADME Study." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 06 (2023): 798–803. http://dx.doi.org/10.25004/ijpsdr.2023.150614.

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One of the common mental illnesses that affect people worldwide is depression. It can impact people from all backgrounds and age groups. Despite having medications for depression, very few people respond to it in an efficient manner. Currently used anti-depressants show side effects like urine retention, nausea, weight gain, cardiovascular disorders, etc. Natural compounds are being evaluated for their therapeutic potential to eradicate these side effects. Metabolites obtained from marine organisms possess diverse beneficial effects. Various sponges, corals, and seaweeds contain compounds with

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Priego Salas, Lidia, and Ana Pérez Rosado. "Relationship of depressant drug use with sleep disorders and psychological wellbeing. Literature review." Enfermería Cuidándote, no. 8 (March 31, 2025): 40. https://doi.org/10.51326/ec.8.4443007.

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Objectives: To explore how the consumption of depressant drugs affects sleep disorders and psychological well-being in adults. Methodology: A literature review was conducted through searches in databases such as PubMed, SciELO, Cochrane, BVS and MEDES, applying inclusion and exclusion criteria. Results and Discussion: The 8 selected studies show that alcohol and benzodiazepine consumption negatively affects sleep quality by reducing its duration and efficiency, increasing the risk of psychiatric issues. Cannabis use was linked to higher levels of psychological distress in women and an inverse

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Devi, Singh, and Ranjeet Singh Chaudhary. "Outcome of Spiritual Practices on Patients Suffering from Depression." International Journal of Toxicological and Pharmacological Research 12, no. 2 (2022): 103–6. https://doi.org/10.5281/zenodo.12525516.

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Depression is one of the most affected disorders all over the world. Studies have found that around 43% of Indians suffer from depression, out of which 11% suffer from moderate depression and 9% suffer from severe depression symptoms. Most youth of India show symptoms of depression because of various life changes, relationship issues, family issues, cyber bullying, etc. Some studies have shown that spirituality and religiosity can be a supplementary method to cure depression and lower the dosage of anti-depressant prescribed. The following study was carried out to check the outcomes of spiritu

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Siddiqui, Shahida Anusha, Ali Ali Redha, Edgar Remmet Snoeck, et al. "Anti-Depressant Properties of Crocin Molecules in Saffron." Molecules 27, no. 7 (2022): 2076. http://dx.doi.org/10.3390/molecules27072076.

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Saffron is a valued herb, obtained from the stigmas of the C. sativus Linn (Iridaceae), with therapeutic effects. It has been described in pharmacopoeias to be variously acting, including as an anti-depressant, anti-carcinogen, and stimulant agent. The therapeutic effects of saffron are harbored in its bioactive molecules, notably crocins, the subject of this paper. Crocins have been demonstrated to act as a monoamine oxidase type A and B inhibitor. Furthermore, saffron petal extracts have experimentally been shown to impact contractile response in electrical field stimulation. Other research

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Baillargeon, Jacques, Sandra A. Black, Salvador Contreras, James Grady, and John Pulvino. "Anti-depressant prescribing patterns for prison inmates with depressive disorders." Journal of Affective Disorders 63, no. 1-3 (2001): 225–31. http://dx.doi.org/10.1016/s0165-0327(00)00188-9.

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Gul, Somia, Sabeen Raza, Zaira Rashid, Maria Ayub, and Ghulam Sarwar. "Neuropharmacological screening of Ficus Carica Linn; Fruit for Anxiolytic and Antidepressant Activity." Bangladesh Journal of Medical Science 17, no. 4 (2018): 606–11. http://dx.doi.org/10.3329/bjms.v17i4.38323.

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Background: Rutin and polyphenol which are present in ficus carica linn are responsible for anti-depressant and anxiolytics effect.Aims: We have conducted the study to evaluate the anti depressant and anxiolytic effect of ficuscaricalinn on mice and compare its effect with well known prescribed anti depressant and anxiolytic drug alprazolam.Methods: Three groups of mice were marked as Control, Reference and Test. Each group comprise of 5 mice. Control group was on normal diet. Reference group was feeded alprazolam at a dose of 0.5mg/60kg while test group were provided two different dilution of

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Ekasari, Wiwied, Retno Widyowati, Tutik S. Wahyuni, et al. "Central nervous system depressant effect of ethanol extract of Senna spectabilis (DC.) H.S.Irwin & Barneby in mice." Journal of Pharmacy & Pharmacognosy Research 11, no. 6 (2023): 1072–78. http://dx.doi.org/10.56499/jppres23.1579_11.6.1072.

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Context: Senna spectabilis (DC.) H.S.Irwin & Barneby which belongs to Fabaceae family is widely used traditionally in the treatment of various diseases and disorders such as constipation, insomnia, anxiety, epilepsy, malaria and skin diseases. Aims: To investigate the central nervous system (CNS) depressant effect of 70% ethanol extract of S. spectabilis leaves (70SSEE) using different neuropharmacological models in mice. Methods: The CNS depressant effect of 70SSEE was investigated by the classical models of depression as elevated plus maze (EPM), hole cross (HC), and thiopental sodium (T

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Bhushan, D. Phani, R. Hari Babu, J. Rashi, M. Tabitha Satya Suvidha, Mounika Susanthi U., and T. Sri Lekha. "A pharmacovigilance study of anti-depressant agents in psychiatric patients at a tertiary care teaching hospital." International Journal of Research in Medical Sciences 8, no. 5 (2020): 1745. http://dx.doi.org/10.18203/2320-6012.ijrms20201921.

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Background: Anti-depressant drugs have great benefit in treating a many psychiatric disorders, including schizophrenia and bipolar disorder, although all these drugs are associated with many potential adverse effects. In this study, the occurrence of adverse effects like weight gain, sleep disturbances, dry mouth were assessed and reported in drug naïve patients Anti-depressant drugs.Methods: It is a prospective observational study of patients attending Psychiatry department in NRI General Hospital of age 10 to 80 years who were prescribed with anti-depressant drugs. The study was conducted fo

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Syari’ah, Atiri, Naflah Rifqi, and Tania Nafida Aimmah. "Esensi Asrar al-Ahkam dalam Lirik Tembang Tombo Ati Gubahan Sunan Bonang sebagai Alternatif Obat Antidepresan." Proceeding of International Conference on Islamic Education (ICIED) 9, no. 1 (2024): 572. https://doi.org/10.18860/icied.v9i1.3190.

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Nowadays, depression is a type of psychiatric disorder that is most often experienced by people. Some people with symptoms of depression choose to go to a psychologist/psychiatrist to undergo treatment with prescription ‘anti-depressant drugs’ where all these chemicals have side effects on the patient’s health. In this case, Islam provides an alternative to these anti-depressants by practicing the essence of ‘Tombo Ati’ song by Sunan Bonang. This study uses the Asrarul Ahkam as a branch of science. That is proof that each of these Islamic syari’ah exists to safeguard religion, mind, soul, line

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Farajzadeh, Mir Ali, Sanaz Barazandeh, Sakha Pezhhanfar, and Mohammad Reza Afshar Mogaddam. "Facile Preparation of Graphene-Modified Magnetic Nanoparticles and Their Application in the Analysis of Four Anti-depressant Drugs in Plasma and Urine." ImmunoAnalysis 3 (May 6, 2023): 4. http://dx.doi.org/10.34172/ia.2023.04.

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Background: Anti-depressants are used to treat depression and some anxiety and personality disorders. In this study, a magnetic sorbent was prepared for the extraction of some anti-depressant drugs from plasma and urine samples. In order to extract the target compounds from the samples, magnetic Fe3 O4 nanoparticles coated with graphene were used as the sorbent. Methods: Vibrating sample magnetometry, scanning electron microscopy, energy dispersive X-ray spectroscopy, Brunauer–Emmett–Teller nitrogen sorption/desorption analysis, Fourier transform infrared spectroscopy, and X-ray diffraction we

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Antony, Benny, A. P. A. Aravind, Merina Benny, Nishant K. Gupta, Biji Joseph, and Anu Sebastian. "Bioactivity Guided Fractionation and Purification of Anti-Depressant Molecule from Ashwagandha (Withania somnifera)." Current Bioactive Compounds 16, no. 5 (2020): 681–86. http://dx.doi.org/10.2174/1573407215666190308155305.

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Background: Ashwagandha (Withania somnifera) is an important herb in the Indian traditional system of medicine for neurological disorders. However, the efforts for isolation and characterisation of a molecule with anti-depressant activity and development as a potent dosage form are limited. Objective: The objective of the present study was to characterize the Ashwagandha extract for its antidepressant fraction or constituent and to improve biological benefits at low doses. Methods: Aqueous methanol extract of Ashwagandha was prepared and fractionated into withanolides and flavonoids rich fract

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Amin, Chris Alberto, Afiahana Andatia, Fathia Daffa Putri, Siti Nurhayati Utami, and M. Yusuf Wijahaska. "The Potential of Cinnamon as Anti-Depressant." Eureka Herba Indonesia 2, no. 2 (2021): 104–8. http://dx.doi.org/10.37275/ehi.v2i2.19.

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Depression is a feeling of loss of interest or pleasure, sadness, feelings of guilt or inferiority, disturbances in sleep or appetite, feelings of tiredness, and poor concentration and the desire to end life. In Indonesia, according to the Indonesian Ministry of Health in 2018, the prevalence of depressive disorders in Indonesia is 6.1%. Based on the 2013 Riskesdas report, the prevalence of suicide in Indonesia is mostly carried out by women, which is around 0.8% compared to men, which has a prevalence of 0.6%. Until now, the first line of depression therapy is the Serotonin Re-Uptake Inhibito

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Bose, Anindya, Anuradha Khuntia, Jayanta Kumar Gupta, and Sudam Si. "Evaluation of central nervous system depressant activity of Cleome rutidosperma." Alternative Medicine Studies 2, no. 1 (2012): 8. http://dx.doi.org/10.4081/ams.2012.e8.

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The central nervous system (CNS) depressant activity of the ethanol extract (200 and 400 mg/kg) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma was investigated in various models. The tested extract and its fractions showed significant (P&lt;0.01) anxiolytic, anticonvulsant activity (in treating petit mal epilepsy) without any unwanted sedation effect. These findings justify the traditional use of this plant in CNS disorders.

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Rasgon, N., B. McEwen, and K. W. Lin. "Insulin Resistance and Telomere Length in Treatment of Depressive Disorders." European Psychiatry 41, S1 (2017): S61—S62. http://dx.doi.org/10.1016/j.eurpsy.2017.01.052.

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Insulin resistance and markers of Allostatic load in depressionIntroductionAmong patients with major depression, increased inflammatory markers at baseline may predict an anti-depressant response. Reducing inflammation may augment response to psychotropic medications. Few studies have investigated an association between Leukocyte Telomere Length (LTL) and therapeutic response in depression, reporting mixed results. No studies assessed LTL and treatment response with PPAR-γ agonists.Objectives(1) LTL as a predictor of anti-depressant response to PPAR-γ agonist in patients with unremitted depres

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Grymel, Mirosława, Patrycja Grabiec, and Kamila Nurkowska. "Cannabidiol – characteristic and application in cosmetology and dermatology." Aesthetic Cosmetology and Medicine 10, no. 6 (2021): 299–303. http://dx.doi.org/10.52336/acm.2021.10.6.06.

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Cannabidiol (CBD) is one of the main active ingredients in hemp. It shows a number of valuable biological properties, such as anti-cancer, anti-depressant or anti-inflammatory. The aim of the article was to present the most importantproperties of cannabidiol and its possible application in cosmetology and dermatology. The wide therapeutic potential of CBD makes it possible to use in the treatment of, not only cancer or mental disorders, but also many dermatoses.

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Vaishnavi S. Gawande and Swati P. Deshmukh. "Review of psychopharmacology." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 365–71. http://dx.doi.org/10.30574/gscbps.2023.25.2.0456.

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In India, one of the primary causes of non-fatal disease burden is psychopharmacological diseases. The prevalence of psychopharmacological disorders in India was one in seven. Despite being used to treat psychological disorders like anxiety, psychosis, depression, and mania, psychopharmacological medications can have unwanted side effects, including tardive dyskinesia, weight gain, weight loss, muscle cramps, dysphoria, gastrointestinal upset, eye problems, and issues with blood tests. We exposed numerous screening techniques for assessing psychopharmacological diseases such anxiety, depressio

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Vaishnavi, S. Gawande, and P. Deshmukh Swati. "Review of psychopharmacology." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 365–71. https://doi.org/10.5281/zenodo.10610011.

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In India, one of the primary causes of non-fatal disease burden is psychopharmacological diseases. The prevalence of psychopharmacological disorders in India was one in seven. Despite being used to treat psychological disorders like anxiety, psychosis, depression, and mania, psychopharmacological medications can have unwanted side effects, including tardive dyskinesia, weight gain, weight loss, muscle cramps, dysphoria, gastrointestinal upset, eye problems, and issues with blood tests. We exposed numerous screening techniques for assessing psychopharmacological diseases such anxiety, depressio

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Zafar, Syeda Hafiza Afsheen, Dr Riffat Farooqui, Ifrah Jawaid, Syeda Afroze, Fahmeed Karim, and Dr Syeda Bushra Zafar. "DOSE-DEPENDENT ANTI-DEPRESSANT EFFECT OF CITRUS PARADISI IN REHABILITATION OF PSYCHOLOGICAL DISORDERS." Pakistan Journal of Rehabilitation 12, no. 1 (2023): 99–106. http://dx.doi.org/10.36283/pjr.zu.12.1/015.

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With advancement in the modern world, psychological issues, including anxiety and depression has become the leading cause of mental illness. Herbal products have been explored to observe their effects in helping such conditions and citrus fruits are found to be among these helping tools. To study this, current research was designed to explore the antidepressant effects of Citrus paradisi in various doses on rodents. Swiss Albino mice were used and fresh extract of Citrus paradisi was prepared. Imipramine was used as the standard drug. Ethical approval was taken from the Board of Advanced Studi

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Lee, Christine, Annabelle Wanson, Sarah Frangou, David Chong, and Katelyn Halpape. "Opioid toxicity due to CNS depressant polypharmacy: A case report." Mental Health Clinician 11, no. 2 (2021): 70–74. http://dx.doi.org/10.9740/mhc.2021.03.070.

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Abstract The interaction between methadone and central nervous system depressants can cause serious adverse effects, including profound sedation, respiratory depression, coma, and death. This poses a challenge in the treatment of patients with concurrent psychiatric and substance use disorders as the combined use is often unavoidable. We report a case of a patient with opioid use disorder, mood disorder unspecified, chronic pain, and chronic obstructive pulmonary disease who experienced 2 serious episodes of CNS and respiratory depression due to polypharmacy-induced opioid toxicity. Careful co

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Sinitsyna, Oksana, Anna Zaychenko, and Iryna Ryzhenko. "INFLUENCE OF VAGINAL ADMINISTRATION OF GLUCOSAMINE HYDROCHLORIDE TO PSYCHO-EMOTIONAL AND LOCOMOTOR ACTIVITY OF SPAY FEMALE RATS." EUREKA: Health Sciences 2 (March 31, 2016): 43–48. http://dx.doi.org/10.21303/2504-5679.2016.00092.

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The significant place in the menopausal syndrome and deficiency of estrogens takes psycho-emotional disorders. Psychosomatic disorders, difficulty of adequate evaluation and correction in menopausal women evidence the fact that this issue is important today. Severe symptoms of menopausal syndrome at violation of psycho-vegetative sphere appear in the early post-menopause, due to final termination of ovarian function and sharply deficiency of estrogens during this period. Intravaginal administration of glucosamine hydrochloride to spay female rats has moderate anti-depressant and anxiolytic eff

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Taher, Yousef A., Awatef M. Samud, Jamal S. Mezogi, and Amel M. Hamza. "CNS depressant activity of Chamomile flower methanol extract in mice." Pakistan Journal of Pharmaceutical Research 2, no. 2 (2016): 98. http://dx.doi.org/10.22200/pjpr.2016298-102.

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Matricaria chamomilla L. (Asteraceae) is a well-known plant in most ancient traditional medicine and highly used for the cure of numerous medical disorders, insomnia included. Using a sleep disturbed model, pentobarbital sodium and ether induce loss of righting reflex were applied for the evaluation of hypnotic and narcosis effects respectively. In the present study, the methanol extract of Matricaria chamomilla flower, at the i.p dose 300 mg/kg, showed considerable restful effect and significantly potentiate the hypnotic effect of pentobarbital sodium, both the latency to sleep and duration t

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Boman, Bruce. "L-Tryptophan: A Rational Anti-Depressant and a Natural Hypnotic?" Australian & New Zealand Journal of Psychiatry 22, no. 1 (1988): 83–97. http://dx.doi.org/10.1080/00048678809158946.

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L-tryptophan is an essential amino acid which is the metabolic precursor of serotonin. Because of the evidence that serotonin deficiency may be an aetiological factor in some sorts of affective disorder and that serotonin is important in the biochemistry of sleep, L-tryptophan has been suggested as a “rational” anti-depressant and as a “natural” hypnotic. This paper reviews the biochemistry and pharmacology of L-tryptophan as well as the literature of the clinical trials that have been conducted with it and suggests that, by itself, L-tryptophan may be useful in mild cases of depression accomp

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Kazmierska-Grebowska, Paulina, Marcin Siwiec, Joanna Ewa Sowa, et al. "Lamotrigine Attenuates Neuronal Excitability, Depresses GABA Synaptic Inhibition, and Modulates Theta Rhythms in Rat Hippocampus." International Journal of Molecular Sciences 22, no. 24 (2021): 13604. http://dx.doi.org/10.3390/ijms222413604.

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Theta oscillations generated in hippocampal (HPC) and cortical neuronal networks are involved in various aspects of brain function, including sensorimotor integration, movement planning, memory formation and attention. Disruptions of theta rhythms are present in individuals with brain disorders, including epilepsy and Alzheimer’s disease. Theta rhythm generation involves a specific interplay between cellular (ion channel) and network (synaptic) mechanisms. HCN channels are theta modulators, and several medications are known to enhance their activity. We investigated how different doses of lamo

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Yaro, Abdullahi Hamza, Musa Aliyu Muhammad, Abdullahi Balarabe Nazifi, and Mohammed Garba Magaji. "Butanol soluble fractions of Cissus cornifolia methanolic leaf extract and behavioural effects in mice." Journal of Phytopharmacology 4, no. 4 (2015): 202–6. http://dx.doi.org/10.31254/phyto.2015.4402.

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Cissus cornifolia Baker - Planch (Family: Vitaceae) is used for various central nervous system disorders. The present study reported the sedative and central nervous depressant effects of fractions (butanol soluble portion and its flavonoid rich fraction) obtained from methanolic leaf extract of Cissus cornifolia using diazepam induced sleep, head-dip and motor coordination tests in mice at doses between 5 to 600 mg/kg body weight. The flavonoid rich column fraction 3 (CF3) significantly (p <0.05) prolonged the duration of sleep in mice at the dose of 10 and 20 mg/kg. Similarly, the butanol

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Ferber, Sari Goldstein, Dvora Namdar, Danielle Hen-Shoval, et al. "The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders." Current Neuropharmacology 18, no. 2 (2020): 87–96. http://dx.doi.org/10.2174/1570159x17666190903103923.

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Mood disorders are the most prevalent mental conditions encountered in psychiatric practice. Numerous patients suffering from mood disorders present with treatment-resistant forms of depression, co-morbid anxiety, other psychiatric disorders and bipolar disorders. Standardized essential oils (such as that of Lavender officinalis) have been shown to exert clinical efficacy in treating anxiety disorders. As endocannabinoids are suggested to play an important role in major depression, generalized anxiety and bipolar disorders, Cannabis sativa was suggested for their treatment. The endocannabinoid

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Peixoto, C., F. Queirós Santos, D. Rego, and H. Medeiros. "Psychedelics and psychiatric disorders: A emerging role." European Psychiatry 64, S1 (2021): S776. http://dx.doi.org/10.1192/j.eurpsy.2021.2054.

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IntroductionRecently there has been renewal in interest of psychedelic research. Classic psychedelics such as lysergic acid diethylamide (LSD), psilocybin and mescaline act pharmacologically as agonists at the 5-HT2A receptor. The entactogens like methylenedioxymethamphetamine (MDMA), acts as a serotonin, dopamine and noradrenaline agonist. All of these drugs are potential candidates in the treatment of multiple psychiatric illnesses.ObjectivesThe authors intend to review the literature on the clinical application of psychedelic drugs in psychiatric disorders.MethodsNon-systematic review of th

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Pawar, Jeevan Atmaram. "Study of Obsessive Compulsive Disorder in Adult Females of Maharashtra population." Indian Journal of Medical and Health Sciences 5, no. 2 (2018): 69–72. http://dx.doi.org/10.21088/ijmhs.2347.9981.5218.2.

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Out of 450 adults females having the symptoms of OCD 38 (8.4%) were diagnosed as OCD. Among these 9 (23%) had obsession 11 (28%) had compulsion and 18 (47%) patient had mixed OCD clinical presentation. The family history of OCD Patients was 14 (36%) were disturbed family, 8 (21%) were divorcee, 13 (34%) were unmarried, 3 (7.8%) were widow. In the obsession study, aggressive patients were 2 (16.6%), sexual obsession were 3 (25%), religious obsession were 2 (16.6%), hoarding obsession were 2 (16.6%), contamination obsession were 2 (16.6%), somatic obsession were 1 (8.3%). Patients presenting wit

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Rotaru, Luciana Teodora, Paul Nedelea, Renata-Maria Varut, et al. "Determining the Influence of Alcohol on the Pharmacological Effect of Benzodiazepines by Molecular Docking Tehnique." Revista de Chimie 70, no. 3 (2019): 814–19. http://dx.doi.org/10.37358/rc.19.3.7013.

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Benzodiazepines represents a large category of medications that were originally developed to treat anxiety disorders or issues with anxiety, seizures, and issues with sleeping. The most common drugs abused along with benzodiazepines are other benzodiazepines, prescription pain medications and alcohol. Alcohol and benzodiazepine have a synergistic depressant effect on the central nervous system. Combining alcohol with benzodiazepines can be dangerous practice even if it is engaged in only occasionally. In the present study, using molecular docking technique we followed the binding energy of ben

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Israr, Juveriya, Indrajeet Singh, Hara Prasad Mishra, et al. "Essential Oil Components of Lemon grass leaves (Cymbopogon citratus) and its importance: A Narrative Review." Journal of Pharmacovigilance and Drug Research 4, no. 2 (2023): 22–25. http://dx.doi.org/10.53411/jpadr.2023.4.2.4.

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Cymbopogon citratus, sometimes known as lemongrass, belongs to the Poaceae family. It is a medicinal plant that contains chemicals that can inhibit the growth of pathogens and boost the body's natural defenses against infectious disorders. Lemongrass is frequently used in baked goods, confections, herbal teas, and other non-alcoholic beverages. Lemongrass essential oil is frequently used as a scent in perfumes and beauty products like creams and soaps. The creation of beta carotene, and other nutrients is derived from citral, which is present in high concentrations in lemongrass essential oil.

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Christopher*, John. "Alcohol's toll on mental health: Understanding the link and finding support." Journal of Mental Health and Aging 7, no. 4 (2023): 1–2. https://doi.org/10.5281/zenodo.11064711.

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Alcohol can have a significant impact on mental health,and understanding the link between alcohol use and mentalhealth is crucial for finding appropriate support. While someindividuals may turn to alcohol as a temporary means ofcoping with stress or emotional difficulties, it can ultimatelyexacerbate mental health issues and create a vicious cycle.Here, I will discuss the toll alcohol can take on mental health,provide an overview of the link between the two, and suggestways to find support. Alcohol is a depressant that can intensifyfeelings of sadness, hopelessness, and anxiety. Regular andexc

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Gangopadhyay, Tanmoy, Ananya Mandal, and Uma Shanker Keshri. "Fluoxetine enhances maximal electroshock seizure threshold in Albino rat model when compared to phenytoin." International Journal of Basic & Clinical Pharmacology 7, no. 1 (2017): 138. http://dx.doi.org/10.18203/2319-2003.ijbcp20175689.

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Background: Individuals with epilepsy have a higher incidence of psychiatric disorders than person without epilepsy. Epidemiological studies have shown that the co-morbidity of epilepsy and depression to be high as 50%. The conventional anti-depressants are believed to lower the seizure threshold making it difficult to treat the co-morbid depression, but animal studies have shown SSRIs, a common anti-depressant, to have anti-convulsant properties. So, we propose to study the anticonvulsant effects of fluoxetine, a SSRI, in albino rats against maximal electroshock seizure and to compare against

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L, Lipoksenla, Viswedenu Kera, Sunit Nath, et al. "Melissa Officinalis: A Review on the Antioxidant, Anxiolytic, and Anti-depressant Activity." Biosciences Biotechnology Research Asia 21, no. 2 (2024): 491–500. http://dx.doi.org/10.13005/bbra/3241.

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ABSTRACT: Anxiety and depression are among the most prevalent neuropsychiatric disorders globally and significantly contribute to the healthcare burden. Various factors, like stressful events, family history, substance abuse, health issues, hormonal imbalances, inflammation, and reactive oxygen species (ROS) mediated oxidative stress. Although numerous medications are available, their efficacy may diminish over time or vary among individuals. Phytomedicine offers a promising approach, focusing on herbal remedies with multiple therapeutic modalities. Melissa Officinalis (MO), a member of the La

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Mathew, Bijo, Della Grace Thomas Parambi, Vishnu Sankar Sivasankarapillai, et al. "Perspective Design of Chalcones for the Management of CNS Disorders: A Mini-Review." CNS & Neurological Disorders - Drug Targets 18, no. 6 (2019): 432–45. http://dx.doi.org/10.2174/1871527318666190610111246.

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: The development of chalcone-based compounds for CNS disorders has been explored by many research groups. Chalcones are being considered as a potent organic scaffold with widespread applications in the field of drug discovery and medicinal chemistry. The planar or semi-planar geometry of chalcones with various functionalities impinged on the terminal aromatic systems renders the molecule its bio-activity including anti-cancer, anti-malarial, anti-microbial, anti-fungal, antileishmanial, anti-viral, anti-diabetic, anti-hypertensive properties, etc. Moreover, cutting-edge research has been exec

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Kumar, Amit, Sayak Khawas, Kumar Anand, and Neelima Sharma. "Comparative Evaluation of Antioxidant and Anti-Depressant Activity of Macrotyloma Uniflorum vs. Clitoria Ternatea Methanolic Leaf Extracts." Journal of Pharmaceutical Technology, Research and Management 11, no. 2 (2023): 115–23. http://dx.doi.org/10.15415/jprtm.2023.112004.

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Background: Depression and anxiety are prevalent psychiatric disorders in the modern era, often attributed to the alterations in signalling neurotransmitters or the release of biogenic amines characterized by changes in consciousness, psychomotor functions, and emotional disturbances. Purpose: Several antidepressant drugs are available; they may cause irreversible adverse effects. Therefore, exploring herbal remedies as an alternative therapy holds potential benefits. Macrotyloma uniflorum and Clitoria ternatea are among the plants traditionally utilized for their anti-depression activity. Met

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Kumar, Amit, Sayak Khawas, Kumar Anand, and Neelima Sharma. "Comparative Evaluation of Antioxidant and Anti-Depressant Activity of Macrotyloma Uniflorum vs. Clitoria Ternatea Methanolic Leaf Extracts." Journal of Pharmaceutical Technology, Research and Management 11, no. 2 (2023): 115–23. https://doi.org/10.15415/jptrm.2023.112004.

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Background: Depression and anxiety are prevalent psychiatric disorders in the modern era, often attributed to the alterations in signalling neurotransmitters or the release of biogenic amines characterized by changes in consciousness, psychomotor functions, and emotional disturbances. Purpose: Several antidepressant drugs are available; they may cause irreversible adverse effects. Therefore, exploring herbal remedies as an alternative therapy holds potential benefits. Macrotyloma uniflorum and Clitoria ternatea are among the plants traditionally utilized for their anti-depression activity. Met

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Kainat, Sana Abdullah Khan Anum Shehzadi. "IMPORTANCE OF C-REACTIVE PROTEIN LEVELS AS A DIAGNOSTIC TOOL OPPOSITE TO LEUKOCYTE FOR EMERGENCY APPENDISECTOMY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 11 (2018): 11163–67. https://doi.org/10.5281/zenodo.1476109.

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<strong><em>Objective: </em></strong><em>The research purpose was to determine the association of depression with the age factor as well as drug intake in the condition of epilepsy.</em> <strong><em>Material and methods: </em></strong><em>The design of our research was cross-sectional, carried out at</em><em> Allied Hospital Faisalabad in the duration form Feb 2017 to Aug 2018. The objective of the research was to analyze despondence state in epilepsy condition.</em> <strong><em> Results:  </em></strong><em>The number of epileptic cases enrolled for our research was just one hundred

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GOMES DE ASSIS, GILMARA, and PAWEL CIESZCZYK. "Exercise − A unique endogenous regulator of irisin, BDNF, leptin and cortisol against depression." Baltic Journal of Health and Physical Activity 12, no. 4 (2020): 1–8. http://dx.doi.org/10.29359/bjhpa.12.4.01.

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Depression is the most prevalent stress-related disorder affecting the population world-wide with potential for an eminent increase after the 2020 pandemic. The mechanisms through which metabolism is involved in depression and stress disorders have been extensively investigated. However, their assessment using exogenous measures is a current limitation. Exercise, as is well reported in animal studies, exerts a critical regulatory influence on the main factors known to participate in these mechanisms. This overview describes the role of cortisol, leptin, irisin and BDNF in the exercise physiolo

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O'Donnell, James T. "Alcohol: Gastrointestinal and other Toxicities." Journal of Pharmacy Practice 7, no. 4 (1994): 196–208. http://dx.doi.org/10.1177/089719009400700407.

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This article will focus on the two areas of alcohol injury: first, the gastrointestinal system, primarily liver toxicity and cirrhosis, and second, the human toll in injury, examining injury epidemiology information that estimates alcohol's involvement in trauma. Any pharmacist consulting in any capacity, especially related to gastrointestinal disorders, will need to understand the significant sociological, pathological, pharmacological, and psychological impact of alcohol. Pharmacists providing care, including dispensing many different drugs to patients, should be cognizant of the interacting

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Iannuzzi, Clara, Maria Liccardo, and Ivana Sirangelo. "Overview of the Role of Vanillin in Neurodegenerative Diseases and Neuropathophysiological Conditions." International Journal of Molecular Sciences 24, no. 3 (2023): 1817. http://dx.doi.org/10.3390/ijms24031817.

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Nowadays, bioactive natural products play key roles in drug development due to their safety profile and strong antioxidant power. Vanillin is a natural phenolic compound found in several vanilla beans and widely used for food, cosmetic, and pharmaceutical products. Besides its industrial applications, vanillin possesses several beneficial effects for human health, such as antioxidant activity in addition to anti-inflammatory, anti-mutagenic, anti-metastatic, and anti-depressant properties. Moreover, vanillin exhibits neuroprotective effects on multiple neurological disorders and neuropathophys

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Obese, Ernest, Elvis Ofori Ameyaw, Robert Peter Biney, Emmanuel Awintiig Adakudugu, and Eric Woode. "Neuropharmacological Assessment of the Hydroethanolic Leaf Extract of Calotropis procera (Ait). R. Br. (Apocynaceae) in Mice." Scientifica 2021 (July 1, 2021): 1–10. http://dx.doi.org/10.1155/2021/5551380.

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Background. Calotropis procera has been widely used traditionally for its analgesic and anti-inflammatory effects. It is also reportedly used in ethnomedicine for mental health disorders including epilepsy even in the absence of supporting scientific data. Thus, the potential of the plant to affect neurological functions was evaluated. Methods. Irwin’s test was performed to determine the effect of the oral administration of the extract (30–3000 mg kg−1) on gross behaviour and physiological function. The activity meter, rotarod, pentylenetetrazol- (PTZ-) induced convulsion, pentobarbitone-induc

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Opeyemi Ezekiel Ojo, Benjamin Olamide Adegoke, Akinyele Patrick Adeyemi, Ifeoluwa Isaac Ogunlowo, Busayo Onafowoke Oguntola, and Idris Ajayi Oyemitan. "Acute toxicity (LD50 values) and neuropharmacological profile of n-hexane fraction of Petiveria alliacea L. (Phytolaccaceae) in mice." World Journal of Biology Pharmacy and Health Sciences 16, no. 2 (2023): 035–49. http://dx.doi.org/10.30574/wjbphs.2023.16.2.0463.

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Background: Petiveria alliacea L. (Phytolaccaceae) ethnomedically is known for its sedative property and beneficial treatment of other central nervous system (CNS) disorders. However, the neuropharmacological properties of the n-hexane extract of this aromatic plant leaf have not been reported, hence this study. Objective: To determine the acute toxicity profile (LD50) and some CNS activities of the n-hexane extract of fresh leaf of P. alliacea (NHEPA) in mice. Method: The fresh leaf of Petiveria alliacea was collected and the n-hexane extract obtained using appropriate technique. The LD50 was

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Midlenko, Oleg Vladimirovich, Vladimir Il'ich Midlenko, Andrey Ivanovich Chavga, Stanislava Konstantinovna Lonskaya, Yakov Dmitrievich Popondopolo, and Irina Olegovna Popondopolo. "MODERN IDEAS ON THE ROLE OF HEMODYNAMIC DISORDERS IN THE PATHOGENESIS OF ACUTE PANCREATITIS." Ulyanovsk Medico-biological Journal, no. 2 (July 3, 2023): 30–46. http://dx.doi.org/10.34014/2227-1848-2023-2-30-46.

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Acute pancreatitis remains one of the most common abdominal diseases, causing a large number of both local and systemic complications. Acute pancreatitis has a high death rate. The pathogenesis of acute pancreatitis is complex and needs careful examination. Many authors suppose, that hemodynamic disorders lead to the development of complications, often fatal. Thus, such disorders need be studied separately.  The review is based on the analysis of articles included in such databases as elibrary.ru, cyberleninka.ru, and e-versions of specialized open access journals. All the articles outli

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Bhat, Ishfaq Ahmad, Shaheen Wasil Kabeer, Mohammad Irshad Reza, Reyaz Hassan Mir, and Muhammad Ovais Dar. "AdipoRon: A Novel Insulin Sensitizer in Various Complications and the Underlying Mechanisms: A Review." Current Molecular Pharmacology 13, no. 2 (2020): 94–107. http://dx.doi.org/10.2174/1874467212666191022102800.

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Background: AdipoRon is the first synthetic analog of endogenous adiponectin, an adipose tissue-derived hormone. AdipoRon possesses pharmacological properties similar to adiponectin and its ability to bind and activate the adipoR1 and adipoR2 receptors makes it a suitable candidate for the treatment of a multitude of disorders. Objective: In the present review, an attempt was made to compile and discuss the efficacy of adipoRon against various disorders. Results: AdipoRon is a drug that acts not only in metabolic diseases but in other conditions unrelated to energy metabolism. It is well- repo

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Zwas, Donna R., Andre Keren, Offer Amir, and Israel Gotsman. "Treatment of Heart Failure Patients with Anxiolytics Is Associated with Adverse Outcomes, with and without Depression." Journal of Clinical Medicine 9, no. 12 (2020): 3967. http://dx.doi.org/10.3390/jcm9123967.

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Background: Few studies have evaluated the effect of pharmacologic treatment of anxiety on outcomes in heart failure (HF) patients. This study examined the impact of treatment with anxiolytics on clinical outcomes in a real-world sample of HF patients with and without depression. Methods: Patients diagnosed with HF were retrieved from a large HMO database. Patients prescribed anxiolytic medication and patients diagnosed with depression and/or prescribed anti-depressant medication were followed for cardiac-related hospitalizations and death. Results: The study cohort included 6293 HF patients.

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Blondeau, Nicolas, Robert H. Lipsky, Miled Bourourou, Mark W. Duncan, Philip B. Gorelick, and Ann M. Marini. "Alpha-Linolenic Acid: An Omega-3 Fatty Acid with Neuroprotective Properties—Ready for Use in the Stroke Clinic?" BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/519830.

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Alpha-linolenic acid (ALA) is plant-based essential omega-3 polyunsaturated fatty acids that must be obtained through the diet. This could explain in part why the severe deficiency in omega-3 intake pointed by numerous epidemiologic studies may increase the brain’s vulnerability representing an important risk factor in the development and/or deterioration of certain cardio- and neuropathologies. The roles of ALA in neurological disorders remain unclear, especially in stroke that is a leading cause of death. We and others have identified ALA as a potential nutraceutical to protect the brain fro

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Turki, M., O. Abidi, S. Ellouze, et al. "Ketamine As A New Therapeutic Option For The Management Of Mental Disorders." European Psychiatry 65, S1 (2022): S877—S878. http://dx.doi.org/10.1192/j.eurpsy.2022.2277.

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Introduction Ketamine is routinely used for anesthetic induction because of its dissociative properties. Recently, it has attracted attention as a rapid-acting anti-depressant, but other studies have also reported its efficacy in the management of diverse psychiatric pathologies previously resistant to treatment. Objectives We aimed to review the efficacity of ketamine in the management of mental disorders. Methods We conducted a litterature review through pubmed database, using the following keywords: “mental illness”; “ketamine”;”depression”;”anxiety disorders”;”eating disorders”;”substance

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Dnyaneshwar, Sonwane* Grishma Bawankar* Aachal Dudhpachare* Vishakha Chindhalore Bharti Machhirke Mayur Deshmukh S. G. Pathan. "A Review on Antimicrobial Property of Costus Speciosus (Keukand)." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 2207–13. https://doi.org/10.5281/zenodo.14744439.

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Keukand, a traditional medicinal plant, has been used for centuries in various cultures. Its bioactive compounds exhibit promising pharmacological activities.   Rhizomes are given in pneumonia, rheumatism, dropsy, urinary diseases, jaundice while leaves are given in mental disorders. Bruised leaves are applied in fever; decoction of stem is used in fever and dysentery. Various other activities are also reported like anti-inflammatory, antiarthritic effect and antifungal activities.  The plant is also  used  in  gout  rheumatism and bronchial  asthma.&nbs

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