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Journal articles on the topic 'Depth editing'

Author: Grafiati

Published: 9 March 2024

Last updated: 31 July 2025

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1

Lu, Shufang, Wei Jiang, Xuefeng Ding, et al. "Depth-aware image vectorization and editing." Visual Computer 35, no. 6-8 (2019): 1027–39. http://dx.doi.org/10.1007/s00371-019-01671-0.

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Lopez-Moreno, Jorge, Jorge Jimenez, Sunil Hadap, Ken Anjyo, Erik Reinhard, and Diego Gutierrez. "Non-photorealistic, depth-based image editing." Computers & Graphics 35, no. 1 (2011): 99–111. http://dx.doi.org/10.1016/j.cag.2010.11.007.

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Zhang, Weiwei, Jianhang Yin, Zhengrong Zhang-Ding, et al. "In-depth assessment of the PAM compatibility and editing activities of Cas9 variants." Nucleic Acids Research 49, no. 15 (2021): 8785–95. http://dx.doi.org/10.1093/nar/gkab507.

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Abstract A series of Cas9 variants have been developed to improve the editing fidelity or targeting range of CRISPR–Cas9. Here, we employ a high-throughput sequencing approach primer-extension-mediated sequencing to analyze the editing efficiency, specificity and protospacer adjacent motif (PAM) compatibility of a dozen of SpCas9 variants at multiple target sites in depth, and our findings validate the high fidelity or broad editing range of these SpCas9 variants. With regard to the PAM-flexible SpCas9 variants, we detect significantly increased levels of off-target activity and propose a trad

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Liu, Sean J., Maneesh Agrawala, Stephen DiVerdi, and Aaron Hertzmann. "ZoomShop: Depth‐Aware Editing of Photographic Composition." Computer Graphics Forum 41, no. 2 (2022): 57–70. http://dx.doi.org/10.1111/cgf.14458.

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Saura-Herreros, Miguel, Angeles Lopez, and Jose Ribelles. "Spherical panorama compositing through depth estimation." Visual Computer 37, no. 9-11 (2021): 2809–21. http://dx.doi.org/10.1007/s00371-021-02239-7.

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AbstractIn this paper, we propose to work in the 2.5D space of the scene to facilitate composition of new spherical panoramas. For adding depths to spherical panoramas, we extend an existing method that was designed to estimate relative depths from a single perspective image through user interaction. We analyze the difficulties to interactively provide such depth information for spherical panoramas, through three different types of presentation. Then, we propose a set of basic tools to interactively manage the relative depths of the panoramas in order to obtain a composition in a very simple w

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Deng, Weihua, Pei Lv, Ming Yi, and Ming Liu. "Understanding co-editing mechanism of wiki-based digital humanities projects." Aslib Journal of Information Management 72, no. 2 (2019): 199–218. http://dx.doi.org/10.1108/ajim-08-2019-0214.

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Purpose The purpose of this paper is to reveal the co-editing mechanism aiming at content creation, and an entry of online encyclopedia is taken as a case, for the purpose of promoting and enhancing the development of wiki-based digital humanities projects (WDHPs), specifically, the projects that focus on gathering contextual information in the culture heritage domain. Design/methodology/approach An exploratory study was conducted by three steps. A representative entry’s editorial records were reorganized to obtain a data set of discussion statements (n=608), based on which linked-structures w

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Siddique, Ashraf, and Seungkyu Lee. "Object-Wise Video Editing." Applied Sciences 11, no. 2 (2021): 671. http://dx.doi.org/10.3390/app11020671.

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Beyond time frame editing in video data, object level video editing is a challenging task; such as object removal in a video or viewpoint changes. These tasks involve dynamic object segmentation, novel view video synthesis and background inpainting. Background inpainting is a task of the reconstruction of unseen regions presented by object removal or viewpoint change. In this paper, we propose a video editing method including foreground object removal background inpainting and novel view video synthesis under challenging conditions such as complex visual pattern, occlusion, overlaid clutter an

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Rees, Holly A., Christopher Wilson, Jordan L. Doman, and David R. Liu. "Analysis and minimization of cellular RNA editing by DNA adenine base editors." Science Advances 5, no. 5 (2019): eaax5717. http://dx.doi.org/10.1126/sciadv.aax5717.

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Adenine base editors (ABEs) enable precise and efficient conversion of target A•T base pairs to G•C base pairs in genomic DNA with a minimum of by-products. While ABEs have been reported to exhibit minimal off-target DNA editing, off-target editing of cellular RNA by ABEs has not been examined in depth. Here, we demonstrate that a current ABE generates low but detectable levels of widespread adenosine-to-inosine editing in cellular RNAs. Using structure-guided principles to design mutations in both deaminase domains, we developed new ABE variants that retain their ability to edit DNA efficient

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Hennessey, James W., and Niloy J. Mitra. "An Image Degradation Model for Depth-augmented Image Editing." Computer Graphics Forum 34, no. 5 (2015): 191–99. http://dx.doi.org/10.1111/cgf.12707.

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10

Drabiak, Katherine. "Untangling the Promises of Human Genome Editing." Journal of Law, Medicine & Ethics 46, no. 4 (2018): 991–1009. http://dx.doi.org/10.1177/1073110518822001.

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This article traces the rapid progression of policy pertaining to human genome germline modifications using genome editing. It provides an overview of how one fertility physician implemented and advertised experimental techniques as part of his fertility clinic services, examines US law and policy, and assesses the impact of rhetoric influencing global policy and interpretation of the law. This article provides an in-depth examination of the medical rationale driving the acceptance of genome editing human embryos in two contexts: to cure disease and treat infertility. It describes complexities

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Dong, Xiuqing, Geng Chen, Zhixiong Cai, et al. "CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients." Cellular Physiology and Biochemistry 47, no. 6 (2018): 2602–12. http://dx.doi.org/10.1159/000491656.

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Background/Aims: Aberrant RNA editing, mediated by adenosine deaminases acting on RNA (ADAR), serves as a post-transcriptional event participating in tumorigenesis and prognosis. However, the RNA editing profiles during HCC progression and their clinical correlations remain unclear. Methods: Multiple tissue samples were collected from an advanced HCC patient. RNA-seq was performed to obtain the RNA editing profiles for each sample. Two RNA editing sites from CDK13 were further validated in 60 HCC patients; and their potential regulatory mechanisms were investigated. Results: In-depth analysis

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Asaoka, Mariko, Takashi Ishikawa, Kazuaki Takabe, and Santosh K. Patnaik. "APOBEC3-Mediated RNA Editing in Breast Cancer is Associated with Heightened Immune Activity and Improved Survival." International Journal of Molecular Sciences 20, no. 22 (2019): 5621. http://dx.doi.org/10.3390/ijms20225621.

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APOBEC3 enzymes contribute significantly to DNA mutagenesis in cancer. These enzymes are also capable of converting C bases at specific positions of RNAs to U. However, the prevalence and significance of this C-to-U RNA editing in any cancer is currently unknown. We developed a bioinformatics workflow to determine RNA editing levels at known APOBEC3-mediated RNA editing sites using exome and mRNA sequencing data of 1040 breast cancer tumors. Although reliable editing determinations were limited due to sequencing depth, editing was observed in both tumor and adjacent normal tissues. For 440 sit

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McGunigal, Lisa. "Reading and Editing “the Exquisitely Bad”." Mark Twain Annual 19, no. 1 (2021): 139–62. http://dx.doi.org/10.5325/marktwaij.19.1.0139.

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Abstract This article examines Mark Twain's lifelong interest in reading and criticizing satirically—both privately and publicly—poorly written poetry, especially obituary poetry, for its emotional detachment and inability to convey the depth of sincere grief.

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Wang, Hao-Qi, Tian Wang, Fei Gao, and Wen-Zhi Ren. "Application of CRISPR/Cas Technology in Spermatogenesis Research and Male Infertility Treatment." Genes 13, no. 6 (2022): 1000. http://dx.doi.org/10.3390/genes13061000.

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As the basis of animal reproductive activity, normal spermatogenesis directly determines the efficiency of livestock production. An in-depth understanding of spermatogenesis will greatly facilitate animal breeding efforts and male infertility treatment. With the continuous development and application of gene editing technologies, they have become valuable tools to study the mechanism of spermatogenesis. Gene editing technologies have provided us with a better understanding of the functions and potential mechanisms of action of factors that regulate spermatogenesis. This review summarizes the a

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Densmore, Casey R., Steven R. Jayne, and Elizabeth R. Sanabia. "Development and Testing of the AXBT Real-Time Editing System (ARES)." Journal of Atmospheric and Oceanic Technology 38, no. 1 (2021): 3–16. http://dx.doi.org/10.1175/jtech-d-20-0110.1.

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AbstractAirborne expendable bathythermographs (AXBTs) are air-launched, single-use temperature–depth probes that telemeter temperature observations as VHF-modulated frequencies. This study describes the AXBT Real-Time Editing System (ARES), which is composed of two components: the ARES Data Acquisition System, which receives telemetered temperature–depth profiles with no external hardware other than a VHF radio receiver, and the ARES Profile Editing System, which quality controls AXBT temperature–depth profiles. The ARES Data Acquisition System performs fast Fourier transforms on windowed segm

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Alzhanov, Raiymbek, and Aida Mashurova. "COMPARISON OF EDITING FEATURES IN KAZAKHSTAN AUTHOR'S AND COMMERCIAL CINEMA." Central Asian Journal of Art Studies 9, no. 4 (2024): 193–204. https://doi.org/10.47940/cajas.v9i4.937.

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Abstract. The article provides a detailed comparative analysis of approaches to editing in auteur and commercial cinematography in Kazakhstan, focusing on how these differences shape different narrative structures and influence viewer perception. The study revealed that auteur, so-called “slow cinema”, is characterized by a viscous tempo, nonlinearity and associativity, based on which it can be concluded that in auteur cinema, editing serves to create a space for reflection and emotional depth. In commercial cinema, on the contrary, editing with frequent frame changes, rhythm, and linearity of

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Adiputra, Albert, Sindung Tjahyadi, and Retna Siwi Padmawati. "Non-ideal Critical Realism Analysis on the Ethical Positions of Secular Doctors Towards Human Genome Editing." Jurnal Filsafat 33, no. 2 (2023): 178. http://dx.doi.org/10.22146/jf.76019.

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Human genome editing could be used to improve human intelligence, appearance, and physical strength. The ethical issues posed by the technology are causing public concern. Secularism views efforts to find moral truth do not depend on supernatural authority. The existence of a secular minority in Indonesia is considered an anomaly in public discourse and is left behind in the morally critical policy-making deliberations on genome editing regulations. The research explored Indonesian secular doctor’s view of human genome editing. This qualitative research used a non-ideal critical realism approa

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Zhao, Ziqi. "Principle and applications of CRISPR/Cas system." Theoretical and Natural Science 20, no. 1 (2023): 221–26. http://dx.doi.org/10.54254/2753-8818/20/20230772.

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With the continuous in-depth research and exploration of the CRISPR/Cas9 system by researchers, people's ability to edit biological genes is also constantly improving. In recent years, gene editing technology as a hot technology has been paid more and more attention, it has played an important role in crop breeding, disease treatment, molecular diagnosis and other aspects. Among the gene editing technologies that have been developed, the emerging CRISPR/Cas technology gene editing system has become the most widely used gene editing technology at present. Compared with the first two generations

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Faiza Bibi, Dr. Shazia Hashmat, and Misbah Ilyas. "The Ethical Concerns of Editing Photos in Media and Its Impact on Beauty Standards." Annual Methodological Archive Research Review 3, no. 6 (2025): 45–61. https://doi.org/10.63075/pze1h768.

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Editing photos is a powerful tool that can shape how people think about beauty. This review study highlights the impact of editing photos on beauty standards, necessitating an in-depth examination of subject. Drawing from a sample of n= 20 research articles selected through inclusion and exclusion criteria and the PRISMA approach, the study synthesizes results from articles published over the time period of 10 years , from 2015 to 2025. The findings show that it’s important for people to learn how to understand and question what they see in the media. There should also be clear rules about how

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Baek, Kwang-Ho, Min-Seo Kim, and Myung-Hee Han. "The study of stereoscopic editing process with applying depth information." Journal of Digital Contents Society 13, no. 2 (2012): 225–33. http://dx.doi.org/10.9728/dcs.2012.13.2.225.

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Hanstock, C. C., M. R. Bendall, H. P. Hetherington, D. P. Boisvert, and P. S. Allen. "Localized in Vivo proton spectroscopy using depth-pulse spectral editing." Journal of Magnetic Resonance (1969) 71, no. 2 (1987): 349–54. http://dx.doi.org/10.1016/0022-2364(87)90068-0.

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Wang, Jingbo. "Machine learning-based risk assessment of gene editing: degeneration during gene editing possibility of target effect." Theoretical and Natural Science 82, no. 1 (2025): 33–38. https://doi.org/10.54254/2753-8818/2024.ka20158.

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CRISPI-Cas 9 technology is currently the most popular gene editing tool, which has been used in biomedical research and clinical treatment, but it also has the problem of off-target effects that cause unexpected gene mutations, which limits its safety and efficacy. Now, various machine learning models have been trained to predict off-target events in order to: Gene editing is more precise. In terms of both accuracy and interpretability there are still issues in the existing models. This paper has focused on reviewing Machine learning archery Off Target Prediction models and their performance.

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Akikol, Rahime, and Bahar Atmaca Demir. "Artificial Intelligence Tools Used in Editing and the Editing Profession." Etkileşim 8, no. 15 (2025): 150–69. https://doi.org/10.32739/etkilesim.2025.8.15.287.

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As a technological branch of art, film has historically collaborated with science to foster the development of new techniques. This collaboration has significantly influenced film production processes, especially the editing stage, which has continuously evolved with the introduction of advanced technologies. The trailer editing of director Luke Scott's 2016 movie Morgan, which would normally take 10-30 days, was completed in just one day with artificial intelligence technology used for the first time. Since then, artificial intelligence tools in film editing have changed the business practice

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Daniel, Melvin A., Raveendar Sebastin, Ju-Kyung Yu, Maria Packiam Soosaimanickam, and Jong Wook Chung. "Enhancing Horticultural Crops through Genome Editing: Applications, Benefits, and Considerations." Horticulturae 9, no. 8 (2023): 884. http://dx.doi.org/10.3390/horticulturae9080884.

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Genome editing has emerged as a powerful tool for accelerating crop improvement in horticultural crops by enabling precise modifications to their genetic makeup. This review provides an in-depth exploration of the applications, methodologies, and potential impacts of genome editing in horticulture. The review focuses on three major genome editing tools in horticulture, CRISPR-Cas9, TALENs, and ZFNs. The underlying mechanisms, applications, and potential challenges associated with each tool are discussed in detail. CRISPR-Cas9, being a versatile and widely used system, has the potential to enha

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Wang, Yi. "Gene-edited animal models in human diseases: A powerful tool." Theoretical and Natural Science 54, no. 1 (2024): 104–9. http://dx.doi.org/10.54254/2753-8818/54/2024au0132.

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Abstract. With the rapid development of gene editing technology, gene editing and the use of animal models have become an integral part of biomedical research. Gene editing has had a disruptive impact in the life sciences, having evolved from the first generation of ZFN, the second generation of TALEN to the current CRISPR. The advent of gene editing technology has greatly increased the possibility of treating hereditary diseases and cancers. Animal models make a key contribution to research into disease research as they provide scientists with a valuable platform for the in-depth understandin

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Li, Ruihuang, Liyi Chen, Zhengqiang Zhang, Varun Jampani, Vishal M. Patel, and Lei Zhang. "SyncNoise: Geometrically Consistent Noise Prediction for Instruction-based 3D Editing." Proceedings of the AAAI Conference on Artificial Intelligence 39, no. 5 (2025): 4905–13. https://doi.org/10.1609/aaai.v39i5.32519.

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Text-based 2D diffusion models have demonstrated impressive capabilities in image generation and editing. Meanwhile, the 2D diffusion models also exhibit substantial potentials for 3D editing tasks. However, how to achieve consistent edits across multiple viewpoints remains a challenge. While the iterative dataset update method is capable of achieving global consistency, it suffers from slow convergence and over-smoothed textures. We propose SyncNoise, a novel geometry-guided multi-view consistent noise editing approach for high-fidelity 3D scene editing. SyncNoise synchronously edits multiple

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Wilson, Trevor C., W. A. Charlton, and Usher Posluszny. "Increased image depth for epi-illumination microscopy." Canadian Journal of Botany 84, no. 3 (2006): 508–13. http://dx.doi.org/10.1139/b06-018.

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Epi-illumination microscopy is a useful tool for studying morphology, but its use is limited by a small depth of field. Using digital editing, we have enhanced the depth of field for epi-illumination micrographs obtained for a number of shoot apices. For each specimen, an epi-illumination microscope fitted with Leitz Ultropak dipping cones was used to capture a series of digital images at successive levels of focus. Adobe® Photoshop® was used to produce one image by assembling only the focused areas of the image series. This stacking method offers a better way to present epi-illumination micro

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van der Berg, Jan Pieter, Lianne M. S. Bouwman, Evy Battaglia, and Gijs A. Kleter. "Future-Proofing EU Legislation for Genome-Edited Plants: Dutch Stakeholders’ Views on Possible Ways Forward." Agronomy 11, no. 7 (2021): 1331. http://dx.doi.org/10.3390/agronomy11071331.

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Genome editing is an emerging, new breeding technology with numerous potential applications in plant breeding. In Europe, genome editing is regarded, in legal terms, as a genetic modification technique, hence plants obtained using these methods fall under the legislation for genetically modified organisms (GMOs). Despite the opportunities that genome editing brings to the plant sector, it also poses challenges to the regulatory system. For example, the enforcement of labelling and traceability requirements for GM foods and feeds may be impossible for small genome edits that are indistinguishab

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Priyanka, K., Shourabh Joshi, Maya Bisen, et al. "CRISPR-Cas9 Applications in Horticultural Crop Improvement." PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY 26, no. 1-2 (2025): 133–41. https://doi.org/10.56557/pcbmb/2025/v26i1-29150.

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The CRISPR-Cas9 genome editing technology has revolutionized plant breeding by enabling precise, efficient, and targeted modifications of plant genomes. In horticultural crops, CRISPR-Cas9 has been widely utilized to enhance traits such as disease resistance, abiotic stress tolerance, improved fruit quality, extended shelf life, and enhanced nutritional value. The ability to precisely edit genes of interest has provided plant breeders with a powerful tool to accelerate crop improvement, reduce reliance on chemical inputs, and enhance sustainability. Advances in CRISPR-based editing techniques,

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Krzyzanowski, Damian, Sushree S. Sahoo, Lili Kotmayer, et al. "Systematic Mapping of Gene-Editable Mutations in GATA2 and SAMD9/SAMD9L Syndromes." Blood 142, Supplement 1 (2023): 1362. http://dx.doi.org/10.1182/blood-2023-190982.

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Germline predisposition to bone marrow failure (BMF) and myelodysplastic syndromes (MDS) cause substantial economic and psychosocial burden and early mortality in affected individuals. Due to the limitations and risks of hematopoietic stem cell transplantation, there is an urgent need for new and innovative treatment approaches. Conventional lentiviral-based gene therapy is not feasible for most BMF/MDS predisposing genes because their uncontrolled overexpression is detrimental and lentiviral vectors might cause insertional mutagenesis. However, new technologies that precisely modify the endog

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Yunes, Maria Cristina, Zimbábwe Osório-Santos, Marina A. G. von Keyserlingk, and Maria José Hötzel. "Gene Editing for Improved Animal Welfare and Production Traits in Cattle: Will This Technology Be Embraced or Rejected by the Public?" Sustainability 13, no. 9 (2021): 4966. http://dx.doi.org/10.3390/su13094966.

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Integrating technology into agricultural systems has gained considerable traction, particularly over the last half century. Agricultural systems that incorporate the public’s concerns regarding farm animal welfare are more likely to be socially accepted in the long term, a key but often forgotten component of sustainability. Gene editing is a tool that has received considerable attention in the last five years, given its potential capacity to improve farm animal health, welfare, and production efficiency. This study aimed to explore the attitudes of Brazilian citizens regarding the application

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Yang, Ruiyan. "Prime editing and its application in the treatment of diseases." Theoretical and Natural Science 58, no. 1 (2024): 137–42. http://dx.doi.org/10.54254/2753-8818/58/20241359.

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Abstract. With the rapid development of biotechnology, gene editing technologies have become an important research direction in the field of biomedicine, and their potential application in disease treatment has become increasingly prominent. As a new type of gene editing technology, prime editors have received widespread attention. In recent years, gene editing technologies have made remarkable progress. For example, CRISPR-Cas9 system has been widely used, which provides new ideas and methods for the treatment of hereditary diseases, cancers, etc. The application scope of PE is even wider, wh

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Board, Editorial. "Adds genuine Value to their English Writing." Global Journal of Enterprise Information System 8, no. 2 (2017): 54. http://dx.doi.org/10.18311/gjeis/2016/7517.

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Felivic Proofreading was formed by a group of experienced editors with the goal of providing world-class proofreading and editing services for students, academicians, businesses/organisations and private individuals across the globe. Our goal is to deliver a thorough and in-depth proofreading and editing service for clients that adds genuine value to their English writing. As we spend small amounts on marketing and advertising, it is only by delivering a remarkable service to our clients that we are able to generate more business for ourselves. We are highly reliant on our clients sharing thei

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Liu, Feng-Lin, Hongbo Fu, Yu-Kun Lai, and Lin Gao. "SketchDream: Sketch-based Text-To-3D Generation and Editing." ACM Transactions on Graphics 43, no. 4 (2024): 1–13. http://dx.doi.org/10.1145/3658120.

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Existing text-based 3D generation methods generate attractive results but lack detailed geometry control. Sketches, known for their conciseness and expressiveness, have contributed to intuitive 3D modeling but are confined to producing texture-less mesh models within predefined categories. Integrating sketch and text simultaneously for 3D generation promises enhanced control over geometry and appearance but faces challenges from 2D-to-3D translation ambiguity and multi-modal condition integration. Moreover, further editing of 3D models in arbitrary views will give users more freedom to customi

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Hong, Qianyi. "Analysis of the Editing Style Characteristics of Tourism Short Videos." International Journal of Education and Humanities 17, no. 2 (2024): 250–52. https://doi.org/10.54097/ypapwk30.

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In this era of information explosion, tourism short videos are like brilliant magic crystals, instantly presenting distant regions and unique cultures before our eyes. With the development of technology and the demand of the Internet, tourism short videos have gradually opened up their own markets, and tourism videos of different types and styles are constantly emerging. This paper aims to explore the editing style characteristics of tourism short videos in depth. Through literature review, case analysis, data analysis and other methods, comprehensively analyze the unique charm of tourism shor

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Safi’i, Muhammad. "Tasawuf Jawa: Kajian Filologis terhadap Naskah Suluk Ahya Ngulumodin." Transformatika: Jurnal Bahasa, Sastra, dan Pengajarannya 9, no. 2 (2025): 297–312. https://doi.org/10.31002/transformatika.v9i2.2241.

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This research aims to describe the condition of Suluk Akya Ngulumodin manuscripts including: This research aims to describe the condition of the manuscript including: manuscript inventory, manuscript description and text study. The edited text uses a standard or critical edition accompanied by critical tools, and the translation of the text uses the following methods: literal, content, and free; Philological theory is used to reveal the cultural results contained in the manuscript. The object of this research is manuscript NB. 1768 of the National Library of Indonesia and BLK.0423-IS44 of the

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Luo, Yikai, and Han Liang. "Cancer Cells Employ the Most Prolific RNA Editors: A Closer Look at the Single-Cell Level." Cancer Research 83, no. 3 (2023): 351–53. http://dx.doi.org/10.1158/0008-5472.can-22-3537.

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Abstract Adenosine-to-inosine (A-to-I) RNA editing is a major source of nucleotide diversification that has significant mechanistic implications in cancer progression and treatment response. However, its activity and prevalence have not yet been systematically determined at a single-cell resolution. Chan and colleagues revealed widespread A-to-I RNA editing events in single cancer cells through an in-depth analysis of a public lung adenocarcinoma single-cell transcriptome dataset. Edits significantly enriched in cancer cells compared to other cell types have the potential to inhibit innate imm

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Ding, Maomao. "Design Innovation and User Satisfaction Improvement of AI Video Creation Tools." Scientific Journal of Technology 7, no. 2 (2025): 112–17. https://doi.org/10.54691/yvrfrh86.

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With the advance of intelligent technology, AI video creation tools are playing an extremely important role in improving the efficiency of creation and optimizing the user experience. This article takes an in-depth look at the innovative design of AI video authoring tools and assesses the impact of these innovations on user satisfaction. The gradual penetration of AI technology in the video creation industry is analyzed in detail, and the application of automated editing and intelligent editing technology is deeply analyzed. Through in-depth analysis of user needs and creative pain points, a s

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Zeng, Lingxing, Xiaoyu Wu, Ziming Chen, and Jian Zheng. "Abstract 4117: ADAR1-mediated RNA editing of KCTD13s promotes pancreatic cancer metastasis by impeding RhoA ubiquitination." Cancer Research 85, no. 8_Supplement_1 (2025): 4117. https://doi.org/10.1158/1538-7445.am2025-4117.

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Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with limited therapeutic options and a poor prognosis. Adenosine-to-inosine (A-to-I) RNA editing, a crucial post-transcriptional modification, introduces nucleotide changes in RNA sequences. However, few protein-recoding editing targets with functional significance have been identified. In this study, we propose that the ADAR1-KCTD13s-RhoA/ROCK1 signaling axis plays a critical role in PDAC progression. Methods: We performed an in-depth analysis of A-to-I RNA editing using RNA-sequencing, validated by Sanger

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Tozaki, Teruaki, Aoi Ohnuma, Kotono Nakamura, et al. "Detection of Indiscriminate Genetic Manipulation in Thoroughbred Racehorses by Targeted Resequencing for Gene-Doping Control." Genes 13, no. 9 (2022): 1589. http://dx.doi.org/10.3390/genes13091589.

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The creation of genetically modified horses is prohibited in horse racing as it falls under the banner of gene doping. In this study, we developed a test to detect gene editing based on amplicon sequencing using next-generation sequencing (NGS). We designed 1012 amplicons to target 52 genes (481 exons) and 147 single-nucleotide variants (SNVs). NGS analyses showed that 97.7% of the targeted exons were sequenced to sufficient coverage (depth > 50) for calling variants. The targets of artificial editing were defined as homozygous alternative (HomoALT) and compound heterozygous alternative (AL

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Gupta, Khushboo, Ashley Christeena Thomas, Vandana Santwani, Binit Kumar Sarangi, Ankush Chandrakar, and Sandip Prasad Tiwari. "CRISPR and Gene Editing in Drug Development: A Revolution in Precision Medicine." Journal of Neonatal Surgery 14, no. 27S (2025): 456–60. https://doi.org/10.63682/jns.v14i27s.6428.

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The discovery and implementation of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology have transformed the landscape of biotechnology and precision medicine. As a revolutionary gene-editing tool, CRISPR enables targeted, efficient, and cost-effective modification of DNA, offering promising therapeutic interventions for a wide range of genetic and acquired diseases. This article provides an in-depth overview of CRISPR’s origins, mechanisms, and applications in drug development, from treating genetic disorders and enhancing cancer immunotherapies to accelerating drug

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Jianyuan Zhang. "Cultural-Clip Editing Strategies in Mobile Short-Video Information Systems: A Meta-analysis Study on Overseas Dissemination of Traditional Culture." Journal of Information Systems Engineering and Management 10, no. 3 (2025): 1336–46. https://doi.org/10.52783/jisem.v10i3.7790.

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Cultural preservation and innovation balance remains important factor that influence the editing of cultural-clips in mobile short-video information systems. Platforms that utilize the mobile short-video information systems include TikTok, Instagram Reels, Facebook reeks, and YouTube Shorts. An important challenge that serves as a barrier to the success of short-video content is the limitation on time with the videos often limited to 15 to 60 second. This aspect poses a greater challenge to the depth of the cultural information to be shared within a single video. Editing strategies that integr

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Kim, Hak Gu, Minho Park, Sangmin Lee, Seongyeop Kim, and Yong Man Ro. "Visual Comfort Aware-Reinforcement Learning for Depth Adjustment of Stereoscopic 3D Images." Proceedings of the AAAI Conference on Artificial Intelligence 35, no. 2 (2021): 1762–70. http://dx.doi.org/10.1609/aaai.v35i2.16270.

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Depth adjustment aims to enhance the visual experience of stereoscopic 3D (S3D) images, which accompanied with improving visual comfort and depth perception. For a human expert, the depth adjustment procedure is a sequence of iterative decision making. The human expert iteratively adjusted the depth until he is satisfied with the both levels of visual comfort and the perceived depth. In this work, we present a novel deep reinforcement learning (DRL)-based approach for depth adjustment named VCA-RL (Visual Comfort Aware Reinforcement Learning) to explicitly model human sequential decision makin

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Pechenov, Pavel Yu, Danil A. Garagulya, Daniil S. Stanovov, and Andrey V. Letarov. "New Effective Method of Lactococcus Genome Editing Using Guide RNA-Directed Transposition." International Journal of Molecular Sciences 23, no. 22 (2022): 13978. http://dx.doi.org/10.3390/ijms232213978.

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Lactococcus lactis is an important industrial microorganism and a widely used model object for research in the field of lactic acid bacteria (LAB) biology. The development of new L. lactis and related LAB strains with improved properties, including phage-resistant strains for dairy fermentation, LAB-based vaccines or strains with altered genotypes for research purposes, are hindered by the lack of genome-editing tools that allow for the easy and straightforward incorporation of a significant amount of the novel genetic material, such as large genes or operons, into the chromosomes of these bac

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YiJin Wu. "Research on the Application of Image Processing and Image Recognition Algorithms in Digital Media in Content Editing and Production." Journal of Electrical Systems 20, no. 3 (2024): 1126–38. http://dx.doi.org/10.52783/jes.3439.

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Image processing and image recognition algorithms are essential to content generation and editing in the digital age. They provide creative ways to improve visual quality, streamline processes, and customize user interfaces. In-depth methods for incorporating cutting-edge image processing and image recognition algorithms into digital media content production and editing workflows are covered in this study. Methods: To maximize visual quality, the research first focuses on pre-processing and improving digital images using the median filtering technique. The Histogram of Oriented Gradients (HOG)

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OHAMA, Mitsuki, Kenta KISHIMOTO, Masato KINOSHITA, Keitaro KATO, and Youhei WASHIO. "The paralogous gene of myostatin deficiency does not improve the growth of Red seabream (Pagrus major)." Borneo Journal of Marine Science and Aquaculture (BJoMSA) 4, no. 1 (2020): 28–35. http://dx.doi.org/10.51200/bjomsa.v4i1.2445.

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To improve livestock and aquaculture-raised fish as food, targeted mutagenesis using genome editing technologies is becoming more realizable. Myostatin (Mstn), which functions as the negative regulator of skeletal muscle growth, is one of the major targets to improve the edible ratio of livestock and farmed fish. We previously reported that the deficiency of Pm-mstn, one of Myostatin paralogs, improves muscle growth and changes body shape in a finfish species, red seabream (Pagrus major), as a result of editing the gene by means of CRISPR/Cas9. In this study, we established Pm-mstnb-deficient

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Yuan, Yuan, and Sheng Lan Liu. "Technique of Line-Carved Relief Editing Based on Mesh Feature Operations." Advanced Materials Research 472-475 (February 2012): 599–604. http://dx.doi.org/10.4028/www.scientific.net/amr.472-475.599.

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A methodology of line-carved relief editing by mesh feature operations was proposed. Feature region of mesh model is firstly identified by curvature criterion. Secondly, profile lines are extracted by such feature operations as clustering, eliminating, retrieving and thinning of feature points. Thirdly, profile lines are optimized by trimming and smoothing operations. Finally, shape of carved curves could be edited by specifying the width and depth of profile lines, and a satisfactory line-carved relief is achieved by nonlinear compression.

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Journal, IJSREM. "Key Features to Improve CRISPR sgRNA Efficacy." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 12 (2024): 1–3. https://doi.org/10.55041/ijsrem40051.

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The CRISPR-Cas9 system has revolutionized genome editing by enabling precise and efficient modification of genetic sequences. However, the efficacy and specificity of this system largely depend on the design and optimization of single guide RNA (sgRNA). Effective sgRNA design requires consideration of several factors, including sequence specificity, GC content, secondary structure formation, and proximity to the protospacer adjacent motif (PAM). These factors influence the binding stability of the sgRNA to the target DNA and the cleavage efficiency of the Cas9 protein. Additionally, minimizing

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Segal, Nancy L. "Justifying Separate Experiences for Twins: Dorothy Burlingham’s Classic Twin Study/Twin Research Reviews: Monozygotic Twins with Maturity-Onset Diabetes, Gene Editing of Chinese Twins, Educational Disadvantage of Early-Born Twins and Developmental Trajectories of Movements in Fetal Twins/In the News: Twins with Nearly Identical License Plates, Rare Case of Fetus-in-Fetu, Twin Brothers Killed at Pearl Harbor, Death of a 96-Year-Old Twin Holocaust Survivor, Death of Male–Female Twin Toddlers in a Heated Car and Confusion of Identical Twin Politicians." Twin Research and Human Genetics 22, no. 6 (2019): 824–28. http://dx.doi.org/10.1017/thg.2019.111.

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AbstractThis article explores the justification for providing separate experiences for twins. The focus is on Dorothy Burlingham’s (1952; Twins: A study of three sets of identical twins with 30 charts. London, UK: Imago) classic, in-depth study of three identical twin-pairs. Implications for how twins are raised currently will be examined. Reviews are presented of twin research concerning monozygotic twins with maturity-onset diabetes, gene editing of fetal Chinese twins, educational disadvantage of early-born twins, and developmental trajectories of twins’ prenatal movements. Some unusual exp

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Hałaczkiewicz, Joanna. "Elektroniczne wydawanie zbiorów korespondencji – dokonania i perspektywy [Electronic publishing of the collection of letters – achievements and perspectives]." Napis XXIII (2017) (December 24, 2017): 302–13. https://doi.org/10.18318/napis.2017.1.18.

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The article discusses the concept of scholarly edition of electronic correspondence and it also describes its most important features such as interactivity, nonlinearity, processuality. Next, technical aspects of creating electronic editions are examined, particularly the issue of coding in TEI-XML. The example is digital edition of letters and texts by Jan Dantyszek prepared by the team from the Department of Editing Sources and Digital Humanities of Warsaw University. Finally, the text presents the possibilities of developing scholarly e-editing of correspondence in the face of the foretold

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