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Journal articles on the topic 'Derinat'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Korneva, E. A., E. V. Dmitrienko, S. Miyamura, M. Noda, and N. Akimoto. "Protective effects of Derinat, a nucleotide-based drug, on experimental traumatic brain injury, and its cellular mechanisms." Medical Immunology (Russia) 23, no. 6 (2021): 1367–82. http://dx.doi.org/10.15789/1563-0625-peo-2392.

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Traumatic brain injury is the most common cause of death and disability in young people including sport athletes and soldiers, people under 45 years of age in the industrialized countries, representing a growing health problem in developing countries, as well as in aging communities. Treatment of the latter is a serious challenge for modern medicine. This type of injury leads to many kinds of disorders and, quite often, to disability. These issue require development of new methods for brain trauma treatment. The new approach to brain trauma treatment was studied in murine experiments. In parti

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Stirmanova, E. R., A. I. Shchipanova, and L. A. Katargina. "THE DEVELOPMENT OF THE RATIONAL SCHEME FOR THE APPLICATION OF DERINAT EYE DROPS, 0.25%, IN THE COMBINED TREATMENT OF EXPERIMENTAL OPHTHALMOHERPES." Russian Pediatric Ophthalmology 7, no. 2 (2012): 46–49. https://doi.org/10.17816/rpoj37486.

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The authors report the results of the experimental evaluation of the efficacy of a new parmaceutical dosage form of derinat eye drops. The study was carried out using the experimental rabbit model of ophthalmoherpes. In the first series of experiments, the therapeutic efficacy of derinat eye drops, 0.25%, was compared with that of 3% zovirax eye ointment. It was shown that derinat produced a well-apparent therapeutic effect comparable with that of zovirax. The clinical efficacy of combined therapy with derinat and zovirax with different intervals between the applications of either preparation

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Brazhnik, E. A., A. A. Glukhov, and M. V. Aralova. "Application of derinat and titanium glycerosolvate aquacomplex in treatment of destructive forms of erysipelas." Grekov's Bulletin of Surgery 176, no. 6 (2017): 71–75. http://dx.doi.org/10.24884/0042-4625-2017-176-6-71-75.

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OBJECTIVE. The authors researched the ways of improvement of treatment results in patients with complicated forms of erysipelas. MATERIAL AND METHODS. There were examined 68 patients with erysipelas complicated by abscess, phlegmon or necrosis of soft tissues. Basic treatment was used for the first group of patients. Combination of basic treatment and application of titanium glycerosolvate aquacomplex were carried out in the second group. Basic treatment and immunomodulator Derinat were applied in the third group. Combined therapy including titanium glycerosolvate aquacomplex and Derinat was u

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Agarkov, N. M., Ya V. Glagoleva, D. O. Zamulin, and S. N. Gontareva. "Dynamics of humoral immunity in gingival fluid during combined immunotherapy in pediatric patients with exacerbation of chronic granulomatous periodontitis." Medical Immunology (Russia) 22, no. 3 (2020): 557–62. http://dx.doi.org/10.15789/1563-0625-doh-1805.

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Chronic granulating periodontitis among children has a high prevalence, which determines the relevance of its research, medical and social significance. The exacerbation of the disease is accompanied by various disorders in the immune system and, above all, at the local level. However, changes in local humoral immunity in children with exacerbation of chronic granulating periodontitis (CGP) have not been studied. Impact of modern immunomodulators and, in particular, Derinat, on pathological changes of local parameters of humoral immunity was not analyzed in pediatric patients with this disorde

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Nechaikin, A. "Efficiency of reparents after plastic operations under the prolapsus pelvic organs." Bulletin of Science and Practice, no. 6 (June 14, 2017): 90–94. https://doi.org/10.5281/zenodo.808247.

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Comparative analysis of the results of treatment of 119 patients with prolapse of pelvic organs was carried out. Patients underwent plastic surgery with vaginal access. In the postoperative period, 38 patients received sanation of the vaginal seams with antiseptic solutions once a day, 36 — treatment of vaginal sutures with 0.25% solution of Derinat for external and topical application once a day, 45 — irrigation of the vaginal seams with aerosol Olazol once a day. The use of Derinat and Olazol in the postoperative period promoted the acceleration of tissue regeneration and improved the indice

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Minaev, Nikolay N., Marina N. Ivanova, Daniil Ju Bugrimov, and Andrey A. Klimovich. "Clinical efficacy of agonist toll-like receptor 9 on the process of reparations after loop conization (LEEP) of the cervix." Journal of obstetrics and women's diseases 65, no. 5 (2016): 101–12. http://dx.doi.org/10.17816/jowd655101-112.

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The aim of this study to explore the use of the agonist Toll-like receptors 9 (TLR 9) in the postoperative period after the LEEP, performed for cervical intraepithelial neoplasia, influences the process tissue repair cervix.Materials and methods. In a randomized, longitudinal, prospective, comparative study included 70 patients with squamous intraepithelial lesions (HSIL и LSIL). Patients first test group (n = 36) was obtained postoperatively as a TLR agonist Derinat 9 immunomodulator. Two patients, the control group (n = 34), postoperative not administered any medication drugs. In the process

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Kolesnikova, E. V., A. V. Zharov, and G. A. Penzhoyan. "Role of cytokines in pathogenesis, diagnosis and efficiency evaluation of immunotherapy in various variants of sclerotic lichen in women." Medical Immunology (Russia) 23, no. 1 (2021): 63–72. http://dx.doi.org/10.15789/1563-0625-roc-2085.

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Our aim was to evaluate diagnostic and pathogenetic significance of plasma cytokines (IL-20, IL-23, IL-10, TNFα, IFNγ) in the patients with various clinical and histological variants of sclerotic lichen and to assess opportunity for their use as effectiveness criteria of immunotherapy for this disease using a drug based on eukaryotic deoxyribonucleic acid (Derinat). The prospective cohort study included assessment of the clinical manifestations (itching and dyspareunia) and measurement of blood cytokine contents (IL-20, IL-23, IL-10, TNFα, IFNγ) in women (n = 114) with various clinical variant

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8

Brazhnik, Elena Anatol'evna, Anton Petrovich Ostroushko, and Anatoliy Vladimirovich Brazhnik. "Derinat in Complex Treatment of Destructive Forms of Erysipelas." Vestnik of Experimental and Clinical Surgery 9, no. 4 (2017): 281. http://dx.doi.org/10.18499/2070-478x-2016-9-4-281-288.

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Актуальность Интерес хирургов к рожистому воспалению (РВ) обусловлен все возрастающим количеством пациентов сгнойно-некротическими осложнениями данного заболевания. Только в нашей клинике доля пациентов с деструктивнымиформами рожистого воспаления составляет около 18% всех пациентов отделения гнойной хирургии.Целью исследования явилось повышение эффективности медикаментозной терапии деструктивных форм рожистоговоспаления (РВ) с учетом современных представлений об этиологии и патогенезе заболевания.Материалы и методы Анализированы результаты лечения 34 пациентов с деструктивными формами РВ. Гру

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9

Hsu, Wen-Li, Jian-He Lu, Mami Noda, et al. "Derinat Protects Skin against Ultraviolet-B (UVB)-Induced Cellular Damage." Molecules 20, no. 11 (2015): 20297–311. http://dx.doi.org/10.3390/molecules201119693.

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10

Lazarenko, Victor Anatolievich, Aleksandr Ivanovich Konoply, Alexander Ivanovich Bezhin, et al. "Correction of the immunity infringements in use antiadhesive polymeric implants in experiment." Journal of Experimental and Clinical Surgery 4, no. 1 (2011): 122–29. http://dx.doi.org/10.18499/2070-478x-2011-4-1-122-129.

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Deficiency of immunity after every surgical intervention? Which is accompanied with a serious illness, anesthesia, manydrugs (antibiotics), develop deficiency of immunity. And adhesive disease of peritoneum is the most frequent complicationof surgical operations. In accordance with some scientist, - implantation of the most effective antiadhesive polymeric agents,can be the cause of development deficiency of immunity too. In experiments in white rats were studies indexes of immunityin experimental abdominal adhesive process with implantation of prophylactic agent Mesogel. Were proved by experi

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11

Novoseletskaya, A. V., and N. A. Tushmalova. "Newly revealed range of action in the preparation derinat: Mnemotropic effect." Moscow University Biological Sciences Bulletin 67, no. 3-4 (2012): 93–95. http://dx.doi.org/10.3103/s0096392512030066.

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12

Liu, Jiadai, Elena G. Rybakina, Eelena A. Korneva, and Mami Noda. "Effects of Derinat on ischemia-reperfusion-induced pressure ulcer mouse model." Journal of Pharmacological Sciences 138, no. 2 (2018): 123–30. http://dx.doi.org/10.1016/j.jphs.2018.08.013.

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13

Berest, I. Ye. "Macroscopic evaluation of nasal mucosal regeneration after trauma (experimental study)." Ural Medical Journal 22, no. 4 (2023): 69–76. http://dx.doi.org/10.52420/2071-5943-2023-22-4-69-76.

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Introduction. Adhesions as a manifestation of pathological regeneration in the nasal cavity after surgical interventions is a rather pressing problem of modern medicine.The aim of the study. was to evaluate the effectiveness of regenerative treatment regimens for nasal mucosal trauma under experimental conditions.Materials and methods. A randomized experimental study was carried out on 480 male white rats, divided into six treatment-dependent groups. At control times (2, 5, 10, 14, 21, 30, 42, 60 days), 10 animals were each removed from the experiment.Results. After nasal musocal trauma on the

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14

Babkin, A. P., A. A. Zuikova, O. N. Krasnorutskaya, et al. "Evaluation of clinical efficacy of Derinat® in form of spray in practice of district therapist." Medical alphabet 1, no. 9 (2019): 38–46. http://dx.doi.org/10.33667/2078-5631-2019-1-9(384)-38-46.

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The widespread worldwide spread of acute respiratory diseases is an urgent problem in health care. Expressed polyetiology of respiratory diseases does not allow to limit the use of specific vaccine preparations and dictates the need to use to combat them a variety of non-specific means that stimulate the natural resistance of the human body. The main pharmacological action of sodium deoxyribonucleate is the stimulation of phagocytic activity of T-helpers and T-killers, increasing the functional activity of neutrophils and monocytes/ macrophages, providing regeneration and repair processes in t

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15

Novoseletskaya, A. V., N. A. Tushmalova, and A. N. Inozemtsev. "Effects of the DNA-containing drug derinat in rats with functional memory impairments." Moscow University Biological Sciences Bulletin 65, no. 3 (2010): 95–97. http://dx.doi.org/10.3103/s0096392510030028.

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16

Rybakina, E. G., S. N. Shanin, E. E. Fomicheva, I. A. Kozinec, and E. A. Korneva. "ACTIVITY OF HOST DEFENSE FUNCTIONS IN STRESS CONDITIONS AND THEIR CORRECTION BY THE DERINAT DRUG." Medical Immunology (Russia) 10, no. 4-5 (2014): 431. http://dx.doi.org/10.15789/1563-0625-2008-4-5-431-438.

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Džiugaitė-Tumėnienė, Rasa, and Milena Medineckienė. "OPTIMISATION OF BUILDING ENERGY SYSTEM TECHNOLOGY CONFIGURATION USING MULTI-CRITERIA DECISION MAKING METHODS / DAUGIAKRITERIŲ METODŲ TAIKYMAS RACIONALIAM PASTATO ENERGETINĖS SISTEMOS TECHNOLOGIJŲ DERINIUI NUSTATYTI." Mokslas - Lietuvos ateitis 5, no. 4 (2013): 410–22. http://dx.doi.org/10.3846/mla.2013.65.

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This article presents the evaluation and optimization algorithm of the building energy system. Two main objectives have been achieved: the optimal configuration of the building energy system has been defined, which minimizes the use of non-renewable sources and reduces the environmental impact of the building. Energy demand for the house has been simulated employing DesignBuilder software. Five configurations of technologies for the building energy system have been chosen and simulated applying Polysun software in order to define the seasonal energy efficiency of the generators of each configu

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18

Зуйкова, Анна Александровна, Ольга Николаевна Красноруцкая, Юлия Александровна Котова, and Даниил Юрьевич Бугримов. "THE EFFECTIVENESS OF AGGREGATION OF THE DRUG DERINAT IN THE COMPLEX TREATMENT OF ARVI IN PRESCHOOL CHILDREN IN THE PRACTICE OF THE DISTRICT PEDIATRICIAN." СИСТЕМНЫЙ АНАЛИЗ И УПРАВЛЕНИЕ В БИОМЕДИЦИНСКИХ СИСТЕМАХ, no. 3 (December 2, 2021): 128–33. http://dx.doi.org/10.36622/vstu.2021.20.3.017.

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Острые респираторные вирусные инфекции (ОРВИ) представляют собой серьезную проблему для общественного здравоохранения во всем мире, вызывая значительную заболеваемость и смертность среди людей всех возрастных групп. Дети заражаются в среднем в два-три раза чаще, чем взрослые. Целью исследования является оценка эффективности препарата Деринат в комплексном лечении острых респираторных вирусных инфекций у детей дошкольного возраста в условиях амбулаторно-поликлинического приема. В исследование были включены дети в возрасте от 3 до 7 лет (включительно) не являющиеся школьниками, с клиническим диа

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19

Fomicheva, E. E., T. A. Filatenkova, S. N. Shanin, and E. G. Rybakina. "Stress-Induced Changes in the Functional Activity of the Neuroendocrine System: The Modulatory Activity of Derinat." Neuroscience and Behavioral Physiology 40, no. 4 (2010): 397–401. http://dx.doi.org/10.1007/s11055-010-9270-z.

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20

Бойко, А. В., Н. Д. Олтаржевская, В. И. Швец, et al. "New opportunities of drug delivery in oncology." ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», no. 3() (September 14, 2018): 120–27. http://dx.doi.org/10.25557/0031-2991.2018.03.120-127.

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Цель исследования. Разработка методов сопроводительной терапии для защиты нормальных органов и тканей, входящих в зону облучения. Методы. В исследование включено 112 больных раком шейки и тела матки после комбинированного или самостоятельного лучевого лечения с 2012 по 2016 гг. У 71 пациентки основной группы в качестве терапии сопровождения применяли гидрогель с деринатом и у 41 больной группы контроля - традиционные методы профилактики (масло оливковое, подсолнечное, метилурациловая мазь). Для профилактики эпителиита слизистой влагалища и шейки матки в основной группе использовали гидрогель в

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D.Yu., Bugrimov, Strakhova N.V., and Mikhailova S.E. "CHANGES IN THE PHYSICAL AND NEUROPSYCHIATRIC STATUSES OF COVID-19 PATIENTS IN RESPONSE TO REHABILITATION." Global problems of modernity 3, no. 1 (2022): 17–23. http://dx.doi.org/10.26787/nydha-2713-2048-2022-3-1-17-23.

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Annotation: Relevance. Over 60% of patients who have undergone COVID-19 have serious physical and neuropsychiatric functional impairments both in the early and late periods after the acute phase of the disease. Target. The quality-of-life impairment in these patients provides a clear rationale for examining the effectiveness of rehabilitative treatment programs in these patients. Materials and methods. The study involved patients who have undergone COVID-19-associated pneumonia and have persistent disorders of physical neuropsychic status, and in general, deterioration in varying degrees of qu

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Biekšienė, Kristina. "Itin smulkių dalelių fiksuotos dozės beklometazono dipropionato ir formoterolio fumarato derinio veiksmingumas, toleravimas ir saugumas, gydant sergančiuosius astma. Penkių klinikinės praktikos tyrimų sudėtinė analizė." Pulmonology and allergology 7, no. 2 (2023): 174–79. http://dx.doi.org/10.37499/pia.1239.

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Šiame straipsnyje aprašoma bendra penkių klinikinės praktikos tyrimų analizė. Šių tyrimų tikslas – įvertinti itin smulkių dalelių fiksuotos dozės beklometazono dipropionato ir formoterolio fumarato (BDP / FF) derinio, skiriamo per suslėgto oro fiksuotų dozių inhaliatorių (angl. pressurized metered dose inhaler, pMDI) arba sausų miltelių inhaliatorių (angl. dry powder inhaler, DPI), veiksmingumą ir saugumą klinikinėje praktikoje, gydant sergančiuosius astma, kurių astma buvo nekontroliuojama skiriant ankstesnį gydymą. Tyrimai atlikti Austrijoje. Bendra penkių klinikinės praktikos tyrimų, kuriuo

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Silenko, G. М., and H. M. Sylenko. "A CLINICAL CASE OF THE USE OF AN IMMUNOMODULATORY DRUG IN THE COMPLEX THERAPY OF SEVERE GENERALIZED PERIODONTITIS." Ukrainian Dental Almanac, no. 4 (December 23, 2020): 32–35. http://dx.doi.org/10.31718/2409-0255.4.2020.06.

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Disorders in the periodontal tissues in generalized periodontitis have a significant negative impact on the patient’s somatic and psycho-emotional health, causing not only dental, but also medical and social difficulties. Although scientific research has been studied, the search for new drugs for treatment and prevention of periodontal tissue diseases, the introduction of new methods have been provided, but the prevalence of generalized periodontitis includes 88-100% among adults. Destructive periodontal changes in chronic generalized periodontitis (CGP) are often irreversible and, in combinat

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Kalinauskaitė-Žukauskė, Virginija. "Itin smulkių dalelių beklometazono dipropionato, formoterolio fumarato ir glikopironio derinio, skiriamo naudojant skirtingus įkvėpimo prietaisus, veiksmingumo ir saugumo palyginamasis tyrimas." Pulmonology and allergology 9, no. 1 (2025): 99–105. https://doi.org/10.37499/pia.1710.

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Trigubos terapijos, sudarytos iš beklometazono dipropionato (BDP), formoterolio fumarato (FF) ir glikopironio (G), skiriamos per itin smulkių dalelių suspausto oro dozuotą aerozolinį inhaliatorių (pMDI), veiksmingumas ir saugumas įvertintas trijuose 52 sav. trukmės lėtinės obstrukcinės plaučių ligos (LOPL) klinikiniuose tyrimuose. Šiuo metu kuriama nauja BDP, FF ir G vaistų forma, skirta vartoti per sausų miltelių inhaliatorių (DPI; „NEXThaler“). Tyrimo tikslas. Palyginti BDP, FF ir G derinio, skiriamo per pMDI, ir BDP, FF ir G derinio, skiriamo per DPI, poveikį plaučių funkcijai. Metodai. Atl

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Hsu, W., and C. Wu. "1103 Derinat extends hair cycle at anagen phase by decreasing the level of TRPCs-mediated intracellular ROS accumulation in skin." Journal of Investigative Dermatology 143, no. 5 (2023): S189. http://dx.doi.org/10.1016/j.jid.2023.03.1115.

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Timchenko, Vladimir Nikolaevich, Svetlana Leonidovna Bannova, Anna Vladimirovna Fedorova, and Anna Nikolaevna Nazarova. "Clinical and laboratory criteria of gravity and the principles of treatment of acute infectious mononucleosis, Epstein-Barr virus etiology of the children." Pediatrician (St. Petersburg) 6, no. 4 (2015): 147–53. http://dx.doi.org/10.17816/ped64147-153.

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The lecture presents the results of many years own research and analysis of the literature on the clinical presentation and therapy of acute infectious mononucleosis, Epstein-Barr viral nature of children. The detailed characterization of the leading clinical syndromes such as fever, intoxication, lymphoproliferative, gepatolienalny syndrome, exanthema. The clinical and laboratory criteria for evaluating the severity of the disease. Principles of drug therapy are presented in accordance with clinical guidelines (treatment protocol) and standards of care for children with infectious mononucleos

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Boyko, A. V., E. A. Dunaeva, L. V. Demidova, A. Yu Korobkova, O. B. Dubovetskaya, and V. Yu Melnikova. "Prevention and treatment of early radiation complications induced by a hydrogel material with derinat in patients with malignant neoplasms of female genital organs." Onkologiya. Zhurnal imeni P.A.Gertsena 5, no. 6 (2016): 5. http://dx.doi.org/10.17116/onkolog2016565-11.

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Золоедов, V. Zoloedov, Земсков, et al. "The Principles of Differentiated Immunotherapy of Pro-Inflammatory Diseases of Different Genesis." Journal of New Medical Technologies 22, no. 2 (2015): 82–85. http://dx.doi.org/10.12737/11841.

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The pathogenesis of various inflammatory diseases - deep pyodermia (DP), purulent soft tissue infection (PSTI), chronic pyelonephritis (SP) and chronic oophoritis (CO) is basis in the formation of diagnostically significant changes in routine hematological parameters and indicators of immune reactivity that can be represented in the form of specific formulas. So, the typical response of routine hematological tests on inflammation in patients from 4 groups was qualitatively universal standard, leukocytosis, neutrophilia, eosinophiles, monocytosis, lymphopenia, accelerated eryt-hrocyte sedimenta

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Yevtushenko, Inna, Dmytro Bilyi, Olesya Tsymerman, and Anastasia Nepochatova. "Clinical manifestation and methods of treatment of pododermatitis in dogs." Scientific Horizons 24, no. 1 (2021): 29–35. http://dx.doi.org/10.48077/scihor.24(1).2021.29-35.

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This paper provides data on the clinical signs of pododermatitis in dogs and also investigates effective treatment regimens. The urgency of the stated problem is due to the growing incidence of pododermatitis in dogs, its polyetiological nature, which requires a multifaceted approach to diagnostics and the introduction of effective treatments methods. Thereby, the purpose of the study was to investigate the clinical manifestations of skin diseases of the distal extremities in dogs and to determine the efficacy of complex therapy of pododermatitis. The studies were based on clinical research me

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Tsybalova, L. M., L. A. Stepanova, M. A. Shuklina, et al. "CROSS-PROTECTIVE PROPERTIES OF AN INFLUENZA VACCINE BASED ON HBC4M2E RECOMBINANT PROTEIN." Problems of Virology, Russian journal 63, no. 2 (2018): 68–76. http://dx.doi.org/10.18821/0507-4088-2018-63-2-68-76.

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One of the main problems in the area of influenza prophylaxis and pandemic prevention is the development of cross-reactive vaccines, i.e. vaccines directed against all subtypes of human influenza viruses. Such vaccines are being developed in many countries for more than 10 years. A number of vaccines are presently undergoing clinical trials. We created Uniflu candidate vaccine based on recombinant HBc4M2e protein consisting of 4 tandem-connected copies of the highly conserved ectodomain of M2 protein of the influenza A virus. These 4 copies were genetically fused to the carrier protein, namely

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Skopin, P., A. Ivashin, Yu Skopina, et al. "Sodium Deoxyribonucleate Prevents Radiation Cystitis in Uterine or Cervical Cancer Patients." Medical Radiology and radiation safety 66, no. 5 (2021): 33–38. http://dx.doi.org/10.12737/1024-6177-2021-66-5-33-38.

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Results: To develop a method for reducing the frequency and severity of early radiation reactions in patients with cancer of the uterus or cervix. Material and methods: We analyzed the results of treatment of 60 patients with cancer of the uterus and cervix, patients received a postoperative course of external beam radiotherapy combined with the intramuscular administration of the Derinat® radioprotector (sodium deoxyribonucleate); in the second arm, they received a postoperative course of external beam radiotherapy and standard therapy in case of radiation cystitis. The assessment of ra

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Matulionė, Jurgita. "Metastazavusio nesmulkiųjų ląstelių plaučių vėžio pirmos eilės gydymas nivolumabu ir ipilimumabu derinyje su dvejais chemoterapijos kursais." Pulmonology and allergology 6, no. 1 (2022): 97–104. http://dx.doi.org/10.37499/pia.973.

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Pastaraisiais metais imuninės kontrolės taško inhibitoriai, atkuriantys priešnavikinį imuninį atsaką, žymiai pakeitė išplitusio nesmulkiųjų ląstelių plaučių vėžio (NSLPV) gydymą. Imuninės kontrolės taško inhibitorius derinant su kitais gydymo būdais (chemoterapija, kitais kontrolinio taško inhibitoriais) pastebėtas žymiai pagerėjęs išgyvenamumas, nepriklausomai nuo programuotos ląstelių žūties ligando (PD-L1) raiškos navikiniame audinyje. Nivolumabo ir ipilimumabo derinys su dviem chemoterapijos kursais yra pirmasis Europos Sąjungoje patvirtintas dviguba imunoterapija pagrįstas gydymo būdas iš

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Тарасова, О. В., А. В. Шумский, О. Н. Павлова, and О. Н. Гуленко. "Study of local immunity in patients with chronic recurrent aphthous stomatitis on the background of therapy." Клиническая стоматология 26, no. 4 (2023): 134–39. http://dx.doi.org/10.37988/1811-153x_2023_4_134.

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Хронический рецидивирующий афтозный стоматит (ХРАС) — это заболевание слизистой оболочки полости рта, характеризующееся появлением болезненных язвочек округлой формы на слизистой оболочке рта. ХРАС может вызывать воспаление и нарушение окислительного гомеостаза в ротовой жидкости и организме в целом. Цель исследования — изучение показателей местного иммунитета у пациентов с ХРАС при разных способах терапии. На первом этапе 60 человек с диагнозом ХРАС (43 женщины и 17 мужчин в возрасте от 26 до 60 лет) в течение 7 дней применяли анестетик (гель Камистад, лидокаин) и антисептик: 30 человек польз

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Dimienė, Ieva, and Skaidrius Miliauskas. "Kvėpavimo ir kraujotakos parametrų, fizinio krūvio tolerancijos bei širdies ir kraujagyslių sistemos saugumo įvertinimas, skiriant dviejų ilgo veikimo bronchus plečiančių vaistų derinius lėtine obstrukcine plaučių liga sergantiems pacientams." Pulmonology and allergology 6, no. 1 (2022): 60–68. http://dx.doi.org/10.37499/pia.968.

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Lėtinė obstrukcinė plaučių liga (LOPL) yra viena iš dažniausiai mirtį sąlygojančių ligų, pasižyminti progresuojančia eiga ir palaipsniui atimanti galimybę gyventi įprastą gyvenimą. LOPL neretai nustatoma vėlai, jau esant ryškiems simptomams, todėl tokiais atvejais turi būti skiriamas ilgo veikimo muskarino receptorių blokatoriaus (IVMB) ir ilgo veikimo β2 agonisto (IVBA) derinys. Šios grupės medikamentai ne tik žymiai pagerina plaučių funkcijos rodiklius ir fizinį pajėgumą, tačiau pastaruoju metu atsiranda vis daugiau duomenų apie jų teigiamą poveikį širdies ir kraujagyslių sistemai, įvertinim

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Butrimas, Grinvydas, Rūta Vindžigalskytė, and Ieva Smolskaitė. "Odos melanomos naujausio gydymo ir išgyvenamumo sąsaja." Lithuanian General Practitioner 26, no. 6 (2022): 394–400. http://dx.doi.org/10.37499/lbpg.986.

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Tyrimo tikslas. Atlikti literatūros šaltinių analizę apie naujausią lokalios OM chirurginį ir išplitusios OM sisteminį gydymą, jo sąsajas su išgyvenamumu. Metodai. Remiantis „Google Scholar“ ir „Pubmed“ duomenų bazių šaltiniais, pagal raktinius žodžius atrinkta ir išanalizuota 13 mokslinių publikacijų pasirinkta tema. Rezultatai. Ilgiausia išgyvenamumo be progresavimo trukmė nustatyta skiriant gydymą kobimetinimo-vemurafenibo deriniu, trumpiausia – ipilimumabo monoterapija. Didžiausia bendrojo išgyvenamumo mediana registruota gydant nivolumabu, mažiausia – ipilimumabo monoterapija. Dažniausios

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Kučinskaitė, Rasa, and Aurika Karbonskienė. "Sedacija virškinimo trakto endoskopinių procedūrų metu." Sveikatos mokslai 26, no. 4 (2016): 74–80. http://dx.doi.org/10.5200/sm-hs.2016.062.

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Virškinimo trakto (VT) endoskopija turi didelę diagnostinę ir gydomąją vertę. Tačiau šios procedūros metu pacientas dažnai patiria nemalonių pojūčių, tokių kaip refleksogeninių zonų dirginimas, pykinimas, kosulys, pilvo pūtimas, skausmas. Todėl ilgesnės trukmės ar traumatiškas endoskopijas rekomenduojama atlikti taikant vidutinę ar gilią sedaciją. Optimalių medikamentų ir jų derinių sedacijai VT endoskopijų metu vis dar ieškoma. Idealiu atveju medikamentai šiai procedūrai turėtų veikti trumpai, sukelti lengvai valdomo lygio sedaciją be pašalinių reiškinių. Dažniausiai naudojama tradicinė sedac

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Biekšienė, Kristina. "Lėtinės obstrukcinės plaučių ligos gydymas beklometazono, formoterolio ir glikopironio deriniu viename inhaliatoriuje. TRITRIAL klinikinės praktikos tyrimo duomenys." Pulmonology and allergology 8, no. 2 (2024): 207–12. http://dx.doi.org/10.37499/pia.1491.

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TRITRIAL tyrime vertintas beklometazono, formoterolio ir glikopironio (BDP, FF ir G) derinio viename inhaliatoriuje veiksmingumas gydant sergančiuosius lėtine obstrukcine plaučių liga (LOPL) klinikinėje praktikoje, vertinant pacientų atsakymus į įvairius klausimynus. TRITRIAL – daugiacentris, perspektyvusis, stebėsenos tyrimas, kuriame pacientams, sergantiems vidutinio sunkumo ir sunkia LOPL, skirtas gydymas triguba terapija – BDP, FF ir G viename inhaliatoriuje 12 mėn. Pagrindinis tyrimo tikslas – įvertinti gydymo BDP, FF ir G deriniu veiksmingumą sveikatos būklei, naudojant LOPL vertinimo te

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Malakauskas, Kęstutis. "Budezonido, glikopironio ir formoterolio derinio veiksmingumas gydant LOPL." Pulmonology and allergology 6, no. 2 (2022): 204–7. http://dx.doi.org/10.37499/pia.1023.

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Budezonidas / glikopironis / formoterolis (BUD / GLI / FORM) yra įkvepiamasis fiksuotų dozių gliukokortikoido, ilgai veikiančio muskarino receptorių blokatoriaus (IVMB) ir ilgai veikiančio β2 agonisto (IVBA) derinys, patvirtintas lėtinės obstrukcinės plaučių ligos (LOPL) palaikomajam gydymui. BUD / GLI / FORM sumažino vidutinio sunkumo ir sunkių LOPL paūmėjimų dažnį, pagerino plaučių funkciją labiau nei BUD / FORM ir (arba) GLI / FORM, taip pat pasireiškė dusulį lengvinamuoju ir su sveikata susijusiu gyvenimo kokybę gerinamuoju poveikiu. BUD / GLI / FORM sumažino mirtingumo dėl visų priežasčių

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Mikučionienė, Rūta, and Vygantas Žėkas. "ENERGIJOS ŠALTINIŲ PARINKIMO ĮTAKA PASTATO ENERGINIAM NAUDINGUMUI / IMPACT OF ENERGY SOURCES SELECTION FOR ENERGY PERFOMANCE OF BUILDING." Mokslas - Lietuvos ateitis 10 (July 5, 2018): 1–6. http://dx.doi.org/10.3846/mla.2018.3248.

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The article analyzes energy supply alternatives for administrative nearly zero energy building in Kaunas. Alternative energy production systems such as biofuel boiler, condensing boiler, heat pumps (air-water and groundwater), solar photovoltaic, solar collectors and combinations of these systems are analysed. The simulation of analysed building energy demands has been made using DesignBuilder modelling software and modelling of energy production alternatives has been performed using energyPRO software. In order to determine the optimal energy production alternative, the combinations of techno

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Kalinauskaitė-Žukauskė, Virginija. "LOPL gydymo optimizavimo svarba ir aklidinio / formoterolio veiksmingumas." Pulmonology and allergology 6, no. 2 (2022): 214–20. http://dx.doi.org/10.37499/pia.1025.

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Lėtinė obstrukcinė plaučių liga (LOPL) yra dažna sergamumo ir mirtingumo priežastis visame pasaulyje. Patiriami kvėpavimo simptomai, apribota kasdienė veikla ir pomėgiai keičia gyvenimo kokybę. Nevaldomi ligos simptomai, paūmėjimai tarsi sukuria užburtą ratą ligai sparčiau vystytis. Ligos valdymui tenka reikšminga sveikatos priežiūros išlaidų dalis. Todėl būtina savalaikiai optimizuoti LOPL gydymą, valdyti ligos simptomus, retinti paūmėjimus, sulėtinti ligos vystymąsi ir užkirsti kelią komplikacijoms. Pernelyg didelis trumpo veikimo β2 agonistų vartojimas yra susijęs su ligos sunkumu ir simpto

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Lukošiūtė, Karolina, Austėja Malinauskaitė, and Liucija Mažonaitė. "LĖTINĖS OBSTRUKCINĖS PLAUČIŲ LIGOS GYDYMO TRIJŲ INHALIACINIŲ VAISTŲ DERINIU POVEIKIS PLAUČIŲ FUNKCIJAI IR LIGOS PAŪMĖJIMO DAŽNIUI." Health Sciences 33, no. 6 (2023): 136–39. http://dx.doi.org/10.35988/sm-hs.2023.251.

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Lėtinė obstrukcinė plaučių liga (LOPL) – tai lėtinė uždegiminė plaučių liga, sutrikdanti oro srautą kvėpavimo takuose. Apžvelgtuose tyrimuose nustatytas statistiškai reikšmingas trigubos inhaliacinių vaistų terapijos poveikis forsuoto iškvėpimo tūrio (FEV1) padidėjimui, kuris vidutiniškai siekė bent 72 ml, lyginant su dvigubos inhaliacinių vaistų terapijos poveikiu ir pasireiškė geresne sergančiųjų plaučių funkcija. Nustatyta, kad vidutinio sunkumo-sunkaus LOPL paūmėjimo dažnis ir mirštamumas nuo LOPL mažesnis pacientų, gydomų trimis inhaliaciniais vaistais grupėje, lyginant su gydomų dvie

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Džiugaitė-Tumėnienė, Rasa, and Vilūnė Lapinskienė. "THE MULTICRITERIA ASSESSMENT MODEL FOR AN ENERGY SUPPLY SYSTEM OF A LOW ENERGY HOUSE / MAŽAENERGIO PASTATO APRŪPINIMO ENERGIJA DAUGIATIKSLIO VERTINIMO MODELIS." Engineering Structures and Technologies 6, no. 1 (2014): 33–41. http://dx.doi.org/10.3846/2029882x.2014.957903.

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Researches on efficient energy supply in new buildings are significant for implementation of energy performance targets for buildings, aiming to increase energy efficiency as well as the share of renewable energy in the total balance of consumed energy and to reduce greenhouse gas emissions to the environment. Many studies suggest integrated assessment methods that combine building energy simulation and optimization methods. However, optimal solutions for case studies are based only on quantitative criteria (energy technical, environmental and economic). Therefore, such an approach is not suff

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Listyani, Tiara Ajeng, and Rina Herowati. "Analisis Docking Molekuler Senyawa Derivat Phthalimide sebagai Inhibitor Non-Nukleosida HIV-1 Reverse Transcriptase." Jurnal Farmasi Indonesia 15, no. 2 (2018): 123–34. http://dx.doi.org/10.31001/jfi.v15i2.445.

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Senyawa derivat phthalimide dilaporkan sebagai kelas baru inhibitor nonnukleosida reverse transcriptase. Analisis docking molekuler senyawa derivat phthalimide terhadap enzim reverse transcriptase diperlukan untuk mengetahui afinitas dan pola interaksi antara senyawa di atas dengan enzim reverse transcriptase. Senyawa derivat phthalimide dioptimasi geometri menggunakan perangkat lunak VegaZZ selanjutnya dilakukan dengan cara preparasi target, preparasi ligan, validasi metode docking, dan analisis docking menggunakan PyRx-Python 0.8 - AutoDock Vina sehingga didapatkan interaksi ligan deng

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Fadhil Pratama, Mohammad Rizki, and Guntur Satrio Pratomo. "Pharmacophore Optimization Of Berberine As HER2 Inhibitor." Jurnal Farmasi Indonesia 14, no. 2 (2018): 109–17. http://dx.doi.org/10.31001/jfi.v14i2.282.

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Penelitian sebelumya menunjukkan bahwa berberin, alkaloid yang terdapat pada beberapa tumbuhan seperti akar kuning (Arcangelisia flava) menunjukkan potensi inhibisi terhadap Human epidermal receptor-2 (HER2). Modifikasi pharmacophore pada struktur kimia berberin diprediksi dapat meningkatkan afinitas derivat berberin terhadap HER2. Tujuan penelitian ini adalah menemukan pharmacophore utama pada berberin yang memiliki pengaruh paling penting terhadap afinitas berberin pada HER2. Metode yang digunakan adalah molecular docking hasil modifikasi pharmacophore terhadap HER2. Hasil dockin

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Listyani, Tiara Ajeng, Diza Aulia Ramadhani, and Danang Raharjo. "ANALISIS DOCKING MOLEKULER BESERTA PREDIKSI ADME SENYAWA DERIVAT FLAVONOID SEBAGAI INHIBITOR ENZIM 15-LIPOXYGENASE-2." Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) 15, no. 2 (2024): 73–83. https://doi.org/10.36308/jik.v15i2.626.

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Derivat flavonoid merupakan metabolit sekunder dari polifenol dan banyak ditemukan pada tumbuhan serta makanan dengan berbagai aktivitas biologi seperti antivirus dan antiinflamasi. Analisis docking molekuler senyawa derivat flavonoid terhadap enzim 15-lipoxygenase-2 bertujuan untuk menyelidiki potensi senyawa derivat flavonoid sebagai penghambat enzim 15-lipoxygenase-2 menggunakan program AutoDock Vina berdasarkan energi bebas pengikatan (ΔG), nilai RMSD, interaksi residu asam amino, serta prediksi ADME yang memenuhi kriteria dari Aturan Lipinski. Hasil docking dari tujuh senyawa derivat flav

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Pancerovienė, Asta, Adelė Stonienė, and Vida Žvinienė. "VERSLUMO UGDYMO IMITACINĖSE BENDROVĖSE PRIVALUMAI IR EFEKTYVUMO DIDINIMAS, TAIKANT MIŠRŲ MOKYMOSI METODĄ." STUDIJOS – VERSLAS – VISUOMENĖ: DABARTIS IR ATEITIES ĮŽVALGOS, no. VII (December 22, 2022): 158–67. http://dx.doi.org/10.52320/svv.v1ivii.244.

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2019 – 2021 metais atliktas Lietuvos imitacinių bendrovių asociacijos užsakytas tyrimas, kurio tikslas buvo atskleisti verslumo ugdymo imitacinėse bendrovėse efektyvumo didinimo galimybes, taikant mišrų (blended – learning) metodą. Tyrimo metodai: analitinė mokslinės literatūros analizė, kiekybinė reprezentatyvi apklausa raštu, statistinė duomenų analizė. Remiantis mokslinės literatūros šaltinių analize, atskleista kad mišraus mokymosi metodas, jungia tradicinį mokymąsi ir virtualų mokymosi metodus bei skatina studentų savarankiškumą, padeda individualizuoti mokymosi procesą, skatina ben

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Purwati, Catur Suci, Lies Mira Yusiati, and Subur Priyono Sasmito Budhi. "KONTRIBUSI EKSKRESI BASAL PURIN TERHADAP TOTAL EKSKRESI DERIVAT PURIN DALAM URIN KAMBING BLIGON DAN KEJOBONG." Buletin Peternakan 37, no. 1 (2013): 6. http://dx.doi.org/10.21059/buletinpeternak.v37i1.1953.

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<p>Penelitian ini bertujuan untuk mengetahui perbedaan kontribusi ekskresi basal terhadap total ekskresi derivat purin dalam urin kambing Kejobong dan Bligon. Percobaan ini didesain menggunakan Independent Student t-test untuk membandingkan ekskresi derivat purin keturunan kambing yang berbeda. Pakan yang diberikan adalah jerami kacang tanah (rendeng). Kambing jantan Bligon dan Kejobong masing-masing 6 ekor digunakan dalam penelitian ini. Percobaan ini dibagi menjadi 3 periode yaitu periode adaptasi selama 14 hari, periode koleksi pada saat ternak diberi pakan ad libitum selama 7 hari, d

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Herwana, Elly. "Fenotip equol-producer dan hubungannya dengan asupan isoflavon dan kesehatan." Jurnal Biomedika dan Kesehatan 3, no. 3 (2020): 159–65. http://dx.doi.org/10.18051/jbiomedkes.2020.v3.159-165.

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Distribusi penyakit osteoporosis, penyakit kardiovaskuler, dan kanker yang berbeda antara populasi Asia dan Kaukasia membawa pemikiran atas keterkaitannya dengan perbedaan variasi diet antara kedua populasi. Studi epidemiologi menunjukkan asupan isoflavon kedelai pada populasi Asia jauh lebih tinggi daripada populasi Kaukasia. Isoflavon disebut sebagai fitoestrogen karena derivat isoflavon yaitu genistein, daidzein dan equol (metabolit daidzein) memiliki struktur molekul yang menyerupai estrogen dan dapat berikatan pada reseptor estrogen sebagai agonis lemah. Terikatnya derivat isoflavon denga

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Timovskaja, Juliana, Oleksij Zotovas, and Mykola Anikusko. "METASTAZAVUSIO KRŪTIES VĖŽIO GYDYMAS TIK GERIAMAISIAIS CHEMOTERAPIJOS IR HORMONŲ TERAPIJOS PREPARATAIS." Medicinos teorija ir praktika 22, no. 5 (2017): 464–71. http://dx.doi.org/10.15591/mtp.2016.075.

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Reikšminiai žodžiai: metastazavęs krūties vėžys, paliatyvi citostatinė terapija, chemoterapija ir hormonų terapija, periodo be progresavimo trukmė, tegafuras, anastrozolas. Tyrimo tikslas. Palyginti įvairių paliatyvios terapijos schemų efektyvumą, tablečių formos preparatų skyrus hormonų receptorių teigiamam, HER-2/neu neigiamam metastazavusiam krūties vėžiui (MKV) gydyti. Objektas ir metodai. Veikale pateikti 81 MKV sergančios pacientės gydymo rezultatai. Atsitiktinės atrankos būdu tiriamosios buvo suskirstytos į tris grupes ir joms buvo skirta tik tablečių formos preparatų. Pirmosios grupės

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Pretti Sitompul, Ma’ruf Tafsin, and Sayed Umar. "SUPLEMENTASI CHITOSAN DERIVAT KARAPAS UDANG TERHADAP PERTUMBUHAN DAN KADAR TOTAL KOLESTEROL DARAH PADA ITIK LOKAL." Jurnal Peternakan Integratif 4, no. 2 (2016): 203–13. http://dx.doi.org/10.32734/jpi.v4i2.2796.

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Kadar total kolesterol yang tinggi menjadi faktor pembatas yang menyebabkan konsumsisecara bebas terhadap daging maupun telur itik dihindari oleh masyarakat. Untuk itu telah dilakukansuatu penelitian pada Mei _ September 2015 untuk mengamati suplementasi chitosan derivat karapasudang di dalam ransum terhadap pertumbuhan dan kadar total kolesterol darah pada itik lokalmenggunakan rancangan acak lengkap dengan 4 perlakuan dan 5 ulangan. Keempat perlakuan terdiriatas T0 = ransum basal tanpa suplementasi; T1 = ransum basal + 9,05% tepung karapas udang; T2 =ransum basal + 1,5% chitosan derivat kara

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