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Journal articles on the topic 'Derivative spectrophotometric'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

SAAD ANTAKLI, Raghad Kabbani, and And Rama Labban. "Analytical Spectrometric Study For Determining Dapagliflozin Propanediol Monohydrate Individually Or In Presence Of Metformin Hydrochloride In Tablets Formulation." JOURNAL OF ADVANCES IN CHEMISTRY 17 (September 10, 2020): 80–87. http://dx.doi.org/10.24297/jac.v17i.8812.

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First simple spectrophotometric method was developed and applied to determine Dapagliflozin Propanediol Monohydrate by Zero Spectrophotometry and First Derivative Spectrophotometric method for determining of Dapagliflozin Propanediol Monohydrate (DAPA) in the presence of Metformin Hydrochloride (MET). Zero spectrophotometric (ZS) was applied for the determination of (DAPA) at 223.5 nm. Linearity range was (2.61– 31.23) µg/mL. Regression analysis showed a good correlation coefficients R2 = 0.9989. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.569 µg/mL and 1.724 µg

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2

Singh Bumbrah, Gurvinder, Rajinder Kumar Sarin, and Rakesh Mohan Sharma. "Derivative Ultraviolet Spectrophotometric Studies on Ignitable Liquids." Journal of Forensic Chemistry and Toxicology 4, no. 1 (2018): 11–21. http://dx.doi.org/10.21088/jfct.2454.9363.4118.2.

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The present article describes the potential utility of derivative ultraviolet (UV) spectrophotometric technique in the discrimination of different kinds of ignitable liquids in their neat states. Derivative UV spectrophotometry is capable of differentiating these ignitable liquids as derivative spectra have more number of points for comparison than their corresponding normal zero order spectrum. Derivative spectra are relatively simple. The technique is rapid, simple, cost-effective and can be used for the screening purpose at the initial stage of investigation. Taking into account the results

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3

Puteri, Adelia, Triyadi Hendra Wijaya, and Hendri Wasito. "Chemometric analysis of fingerprinting derivative spectrophotometry for authentication of shallots." International Journal of Basic and Applied Science 13, no. 2 (2024): 74–83. http://dx.doi.org/10.35335/ijobas.v13i2.406.

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The Bima Brebes, variety of shallots, was in high demand, which led to mixing with other varieties. Derivative spectrophotometric fingerprinting combined with chemometrics was used to distinguish between authentic and adulterated shallot varieties. The objective of this study was to identify the original spectra and their derivative spectrophotometric fingerprinting, as well as classify and differentiate between shallot varieties using chemometrics. UV-Visible (UV-Vis) spectrophotometry was used to test essential oil samples from three shallot varieties and their mixtures, followed by spectral

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4

Antakli, Saad, Leon Nejem, and Monzer Alraii. "Determination of Glibenclamide By Analytical Spectrophotometry." JOURNAL OF ADVANCES IN CHEMISTRY 18 (April 24, 2021): 40–48. http://dx.doi.org/10.24297/jac.v18i.8963.

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Simple and rapid spectrophotometric method was developed and applied to determine Glibenclamide (GB) by zero spectrophotometric method and first derivative spectrophotometric method for determining of (GB) in the presence of Metformin hydrochloride (MET). Zero spectrophotometric (ZS) method was applied for the determination of (GB) at λmax = 300 nm. Linearity range was (4 – 360) μg/mL. Regression analysis showed a good correlation coefficients R2 = 0.99993. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.65 μg/mL and 2.31 μg/mL, respectively. First derivative spectr

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5

Kurdaikar, S. S., A. Fernandes, S. V. Gandhi, P. Pattewar, and A. A. Mahajan. "Spectrophotometric Determination of Carbimazole and Its Major Impurity, Degradation Product and Metabolite: Methimazole -=SUP=-*-=/SUP=-." Оптика и спектроскопия 129, no. 7 (2021): 972. http://dx.doi.org/10.21883/os.2021.07.51090.1046-21.

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The present research work was carried out in order to develop simple, accurate and precise UV sprctrophotometric methods having comparable sensitivity as that of sophisticated chromatographic techniques. Two methods were developed namely first derivative spectrophotometry and ratio spectra derivative spectrophotometry for accurate determination of specified impurity methimazole (imp A) in presence of drug carbimazole. First derivative spectrophotometric method involves recording of zero order spectra of both the drugs carbimazole and methimazole and its mixture in the range of 200-400 nm and s

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6

Drozd, J. "Comparison of classic and derivative UV spectrophotometric methods for determination of dextromethorphani hydrobromidum." Acta Facultatis Pharmaceuticae Universitatis Comenianae 59, no. 1 (2012): 22–29. http://dx.doi.org/10.2478/v10219-012-0014-8.

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Comparison of classic and derivative UV spectrophotometric methods for determination of dextromethorphani hydrobromidumA method for the fast determination of dextromethorphani hydrobromidum in pharmaceutical preparations by classic spectrophotometry - zero and first-, second- and third-order derivative spectrophotometry, using "peak - peak" (P - P) and "peak - zero" (P - O) measurements has been performed. The calibration curves are linear within the concentration range of 1.0 - 25.0 μg ml-1 for dextromethorphani hydrobromidum. The procedure is simple, rapid and the results are reliable.

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7

Youssef, Rasha M. "Validated Stability-Indicating Methods for the Determination of Nizatidine in the Presence of Its Sulfoxide Derivative." Journal of AOAC INTERNATIONAL 91, no. 1 (2008): 73–82. http://dx.doi.org/10.1093/jaoac/91.1.73.

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Abstract Four new selective, precise, and accurate methods are described for the determination of nizatidine (NIZ) in the presence of its sulfoxide derivative in both the raw material and pharmaceutical preparations. Method A is based on zero-order (0D), first-derivative (1D), and second-derivative (2D) spectrophotometric measurement of NIZ in aqueous solution at the zero-crossing point of its sulfoxide derivative (at 314, 295334, and 318348 nm, respectively). Method B is a 1DD spectrophotometric method based on the simultaneous use of the first derivative of the ratio spectra and the measurem

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8

Turak, Fatma, and Mahmure Ustun Ozgur. "Simultaneous Determination of Allura Red and Ponceau 4R in Drinks with the Use of Four Derivative Spectrophotometric Methods and Comparison with High-Performance Liquid Chromatography." Journal of AOAC INTERNATIONAL 96, no. 6 (2013): 1377–86. http://dx.doi.org/10.5740/jaoacint.12-393.

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Abstract Four simple, rapid, sensitive, and accurate spectrophotometric methods were developed for the simultaneous determination of Allura Red (AR) and Ponceau 4R (P) without previous chemical separation. The first method, derivative spectrophotometry, depends on first derivative spectrophotometry with zero-crossing and peak-to-base measurement. The second method, derivative ratio spectrophotometry, uses the first derivative of the ratio spectra. The ratio spectra are obtained by dividing the absorption spectra of a binary mixture by that of one of the components. The third method, differenti

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9

Lastra, Olga C. "Derivative Spectrophotometric Determination of Nitrate in Plant Tissue." Journal of AOAC INTERNATIONAL 86, no. 6 (2003): 1101–5. http://dx.doi.org/10.1093/jaoac/86.6.1101.

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Abstract A derivative spectrophotometric method was developed to determine NO3– –N in plant tissues. The method is based on measurement of the first-derivative spectrum of nitrosalicylic acid in basic solution. The nitrosalicylic acid was obtained by reaction of samples with salicylic acid in concentrated sulfuric acid and was used by Cataldo et al. in nonderivative spectrophotometry. The main strength of this technique is the lack of matrix background interference, typical of plant extracts in traditional spectrophotometric methods. This method is fast, inexpensive, easy-to-apply, and highly

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10

Dinçel, Aysun, Elif Gök-Topak, and Feyyaz Onur. "Simultaneous determination of emtricitabine and tenofovir disoproxil fumarate in pharmaceutical preparations using spectrophotometric, chemometric and chromatographic methods." Journal of the Serbian Chemical Society, no. 00 (2024): 31. http://dx.doi.org/10.2298/jsc230909031d.

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Simple, accurate and sensitive spectrophotometric, chemometric and chromatographic methods were used for the simultaneous determination of emtricitabine (ETC) and tenofovir disoproxil fumarate (TDF) in tablets. In 1st derivative spectrophotometry, first derivative spectra of the solution of ETC and TDF in water were recorded as ?? = 4 nm and first derivative absorbances were measured at the zero-crossing points at 297.3 nm and 281.2 nm for ETC and TDF respectively. In ratio 1st derivative spectrophotometry measurements were recorded at 239.0 nm and 270.2 nm for ETC and TDF respectively. Then a

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11

Turak, Fatma, and Mahmure Ustun Ozgur. "Validated Spectrophotometric Methods for Simultaneous Determination of Food Colorants and Sweeteners." Journal of Chemistry 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/127847.

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Two simple spectrophotometric methods have been proposed for simultaneous determination of two colorants (Indigotin and Brilliant Blue) and two sweeteners (Acesulfame-K and Aspartame) in synthetic mixtures and chewing gums without any prior separation or purification. The first method, derivative spectrophotometry (ZCDS), is based on recording the first derivative curves (for Indigotin, Brillant Blue, and Acesulfame-K) and third-derivative curve (for Aspartame) and determining each component using the zero-crossing technique. The other method, ratio derivative spectrophotometry (RDS), depends

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12

Marques, Morgana Souza, Fernando Dal Pont Morisso, Fernanda Poletto, and Irene Clemes Külkamp Guerreiro. "Development of derivative spectrophotometric method for simultaneous determination of pyrazinamide and rifampicin in cubosome formulation." Drug Analytical Research 5, no. 1 (2021): 46–50. http://dx.doi.org/10.22456/2527-2616.111454.

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The ultraviolet spectrophotometry analysis for quantitative assay of drugs is a method accurate, sensitive, selective and reproductive with the advantage of being a simple and less expensive method. In this study, a derivative ultraviolet spectrophotometric method was developed for simultaneous determination of pyrazinamide (PYZ) and rifampicin (RIF). The spectrophotometric method was evaluated according to validation guidelines for specificity, linearity, limits of detection and quantification, precision, accuracy and robustness. The first-derivative spectra were obtained and by the zerocross

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13

Atole, Dipali M., and Hrishikesh H. Rajput. "ULTRAVIOLET SPECTROSCOPY AND ITS PHARMACEUTICAL APPLICATIONS- A BRIEF REVIEW." Asian Journal of Pharmaceutical and Clinical Research 11, no. 2 (2018): 59. http://dx.doi.org/10.22159/ajpcr.2018.v11i2.21361.

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Rapid and easy analytical methods are needed due to increasing number of multicomponent formulations, biotherapeutic products and samples of complex matrix in que. Number of Ultraviolet (UV) spectrophotometric methods used for these purpose. Different types of UV spectrometric methods developed on the basis of principle of additivity, absorbance difference, processing absorption spectra. The aim of this review is to present information on simultaneous equation method, difference spectrophotometry, derivative spectrophotometry, absorbance ratio spectra, derivative ratio spectra, successive rati

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14

Abramovic, Biljana, Vesna Anderluh, Ferenc Gaál, and Daniela Sojic. "Derivative spectrophotometric determination of the herbicides picloram and triclopyr in mixtures." Journal of the Serbian Chemical Society 72, no. 8-9 (2007): 809–19. http://dx.doi.org/10.2298/jsc0709809a.

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A derivative spectrophotometric method for the determination of the herbicides picloram (4-amino-3,5,6-trichloropicolinic acid) and triclopyr (3,5,6-trichloro- 2-pyridyloxyacetic acid) in mixtures was developed in this work. Derivative spectrophotometric determination of the selected herbicides was preceded by investigations concerning the influence of pH, in the pH interval from 1 to 9. At pH 3.2, picloram and triclopyr solutions are stable under daylight for nine months. This pH was used for all subsequent determinations. It was also found that the use of the first derivative of the spectra

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15

Journal, Baghdad Science. "Derivative Zero - Crossing Spectrophotometry Of Binary Mixtures Of Acetyl Acetonates Of Micro – Amounts Of Mn (Ii) And Al (Iii)." Baghdad Science Journal 10, no. 3 (2013): 866–82. http://dx.doi.org/10.21123/bsj.10.3.866-882.

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New derivative molecular absorption spectrophotometric methods have been developed for the determination of Al (III) , Mn (II) , individually and binary mixtures . The aim of this model of study is to obtain analytical results characterized by adequate standard of analytical figures of merits through application of derivative Spectrophotometry (dnA/d?n). The two metals acetyl acetonates are chemically stable and are widely used as catalysts . Where Interferences are probable due to very close or nearby peaks or Summits, the Zero – Crossing derivative measurement technique is used to avoid inte

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16

Basheer, Hassan M., Fathil Jasim, and Mohammed A. Al Hammed. "Derivative Zero - Crossing Spectrophotometry Of Binary Mixtures Of Acetyl Acetonates Of Micro – Amounts Of Mn (Ii) And Al (Iii)." Baghdad Science Journal 10, no. 3 (2013): 866–82. http://dx.doi.org/10.21123/bsj.2013.10.3.866-882.

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New derivative molecular absorption spectrophotometric methods have been developed for the determination of Al (III) , Mn (II) , individually and binary mixtures . The aim of this model of study is to obtain analytical results characterized by adequate standard of analytical figures of merits through application of derivative Spectrophotometry (dnA/d?n). The two metals acetyl acetonates are chemically stable and are widely used as catalysts . Where Interferences are probable due to very close or nearby peaks or Summits, the Zero – Crossing derivative measurement technique is used to avoid inte

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17

Panda, Sagar S., and Ravi Kumar V.V. Bera. "HPTLC AND FIRST DERIVATIVE UV-SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF VILAZODONE IN PHARMACEUTICALS." Indian Drugs 60, no. 01 (2023): 61–66. http://dx.doi.org/10.53879/id.60.01.12718.

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A new HPTLC method and a sensitive UV spectrophotometric method were established for estimating vilazodone hydrochloride in its pharmaceutical formulations. An environment-friendly chromatographic mobile phase consisting of ethyl acetate: toluene: formic acid (5:4:1, V/V/V) along with ultraviolet densitometric detection at 240 nm using pre-coated silica gel plates was used. First derivative UV spectrophotometric determinations were performed using methanol as solvent, and amplitudes were measured for quantification purposes. Validation studies were compliant with ICH guidance. Vilazodone shows

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18

Karacan, Elif, Mehmet Gokhan Çaġlayan, İsmail Murat Palabiyik, and Feyyaz Onur. "Liquid Chromatographic and Spectrophotometric Determination of Diflucortolone Valerate and Isoconazole Nitrate in Creams." Journal of AOAC INTERNATIONAL 94, no. 1 (2011): 128–35. http://dx.doi.org/10.1093/jaoac/94.1.128.

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Abstract A new RP-LC method and two new spectrophotometric methods, principal component regression (PCR) and first derivative spectrophotometry, are proposed for simultaneous determination of diflucortolone valerate (DIF) and isoconazole nitrate (ISO) in cream formulations. An isocratic system consisting of an ACE® C18 column and a mobile phase composed of methanol–water (95+5, v/v) was used for the optimal chromatographic separation. In PCR, the concentration data matrix was prepared by using synthetic mixtures containing these drugs in methanol–water (3+1, v/v). The absorbance data matrix co

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19

Aher, Smita S., Jayshree S. Gawali, and Ravindranath B. Saudagar. "UV-Spectrophotometric Estimation of Olopatadine hydrochloride in Bulk and Pharmaceutical Dosage Form by Zero, First and Second Order Derivative Methods." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 519–24. http://dx.doi.org/10.22270/jddt.v9i4-s.3378.

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Simple and accurate UV spectrophotometric methods by Zero, First and Second order derivative method have been developed and validated for the estimation of Olopatadine hydrochloride in bulk and its pharmaceutical dosage form. The standard and sample solutions of Olopatadine hydrochloride were prepared in methanol and water. Olopatadine hydrochloride was estimated at 299, 289 and 267 nm for the derivative UV-spectrophotometric method. Beer’s law was obeyed in the concentration range of 20 to 120 μg / mL with coefficient of correlation value 0.9996, 0.999 and 0.999 for Zero, First and Second ord

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20

Rutvik, Pandya, Kachhiya Heta, N. Desai Mubassira, Patel Dipexa, L. Paradeva Bindiya, and Tandel Jinal. "UV-Spectroscopic Methods Development and Validation for Estimation of Desidustat." Journal of Advances in Pharmaceutical Sciences 2, no. 1 (2024): 42–51. https://doi.org/10.5281/zenodo.10616941.

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<em>Zero order, first order derivative and Difference spectrophotometric methods were developed for routine estimation of Desidustat and validated as per ICH guideline. Linearity obtained for zero order and first order derivative methods from 2-7 </em> <em>g/ml</em><em> with R<sup>2</sup> 0.9965 and 0.9961, respectively and for difference spectrophotometric method 4-12 </em> <em>g/ml</em><em>. with R<sup>2</sup> 0.9978. Standard spiking method for accuracy study was performed and % recovery was found 99.01 to 99.51 % for zero order, 99.49 to 101 % for first order derivative and 99.6 to 10

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Attimarad, Mahesh, Muhammad Shahzad Chohan, and Abdulmalek Ahmed Balgoname. "Simultaneous Determination of Moxifloxacin and Flavoxate by RP-HPLC and Ecofriendly Derivative Spectrophotometry Methods in Formulations." International Journal of Environmental Research and Public Health 16, no. 7 (2019): 1196. http://dx.doi.org/10.3390/ijerph16071196.

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Simple, fast, and precise reversed-phase (RP)-high-performance liquid chromatography (HPLC) and two ecofriendly spectrophotometric methods were established and validated for the simultaneous determination of moxifloxacin HCl (MOX) and flavoxate HCl (FLX) in formulations. Chromatographic methods involve the separation of two analytes using an Agilent Zorbax SB C18 HPLC column (150 mm × 4.6 mm; 5 µm) and a mobile phase consisting of phosphate buffer (50 mM; pH 5): methanol: acetonitrile in a proportion of 50:20:30 v/v, respectively. Valsartan was used as an internal standard. Analytes were monit

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Sirisha, K*. "Estimation of a New Gabapentin Derivative in Capsule Dosage Form by New Validated UV Spectrophotometric Method." International Journal of Pharmacy and Biological Sciences (IJPBS) 13, no. 3 (2023): 26–35. https://doi.org/10.5281/zenodo.10260625.

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AbstractA new simple, sensitive, and economic spectrophotometric method has been developed and validated for the determination of a new gabapentin derivative in pure form and pharmaceutical preparations. The method is based on the reaction between the amino group of gabapentin with benzene sulphonyl chloride to form the gabapentin derivative (sulphonamide) via addition-elimination mechanism. The new gabapentin derivative was prepared by two different methods using sodium carbonate (method 1) and sodium hydroxide (method 2). The colourless product obtained was analysed by TLC. In UV-spectrophot

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Shirkhedkar, Atul A., and Saurabh B. Ganorkar. "NOVEL ZERO ORDER UV-SPECTROPHOTOMETRIC AND FIRST ORDER DERIVATIVE UV-AUC METHODS FOR ESTIMATION OF ETOMIDATE IMPARTING HYDROTROPIC SOLUBLIZATION." INDIAN DRUGS 52, no. 04 (2015): 15–20. http://dx.doi.org/10.53879/id.52.04.10214.

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Simple, novel UV-spectrophotometric methods have been developed and validated for the estimation of etomidate imparting a hydrotropic solublization phenomenon. Etomidate is an imidazole derivative, approved as a short acting intravenous anesthetic having poor water solubility. As the UV-spectrophotometric estimation was not seen in any published literature, we have reported it here; zero order UV-spectrophotometry (Method I) and First Order Derivative UV-spectrophotometry (Method II) with the application of hydrotropy to counteract the poor water solubility of etomidate. The present research e

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V. U., Barge, Jadhav P. B., Attarde S. R., Kodre K. V., and Patil R. Y. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF MEGLUMINE IN BULK." JOURNAL OF ADVANCES IN CHEMISTRY 10, no. 3 (2014): 2325–28. http://dx.doi.org/10.24297/jac.v10i3.2281.

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UV, first, second and third derivative spectrophotometric methods have been developed for the determination of meglumine. The solutions of standard and sample were prepared in distilled water. For the first method i.e. calibration curve UV spectrophotometric method, the quantitative determination of the drug was carried at 254 nm and the linearity range was found to be 10 – 60 µg/ml. For the first, second, third derivative spectrophotometric methods the drug was determined at 247 nm, 216 nm, 266 nm with the linearity range 10 – 60 µg /ml. The calibration graphs constructed at their wavelength

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Varghese, Anitha, and A. M. A. Khadar. "First Order Derivative Spectrophotometric Determination of Thorium in Geological Samples Using Diacetylmonoxime p-hydroxybenzoylhydrazone." Mapana - Journal of Sciences 11, no. 1 (2012): 15–30. http://dx.doi.org/10.12723/mjs.20.2.

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A simple, selective and sensitive spectrophotometric method has been developed for the determination of trace amounts of thorium using a newly synthesised reagent diacetylmonoximep-hydroxybenzoylhydrazone (DMPHBH) in the presence of Triton X-100. The molar absorptivity and Sandell’s sensitivity of the coloured species at pH 4.4 were found to be 4.20 x 104 L mol-1 cm-1 and 5.5 ng cm-2, respectively. Beer’s law is obeyed in the range 0.35 -3.8 mg mL-1 of thorium(IV) at 410 nm. The stoichiometry of the complex was found to be 1:2 (Th(IV): DMPHBH). A highly selective first order derivative spectro

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Ganorkar, S. B., D. M. Dhumal, and A. A. Shirkhedkar. "APPLICATION OF UV-SPECTROPHOTOMETRY FOR DETERMINATION OF ZILEUTON IN BULK AND IN TABLETS." INDIAN DRUGS 50, no. 06 (2013): 40–44. http://dx.doi.org/10.53879/id.50.06.p0040.

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Zileuton is an orally active inhibitor of 5-lipoxygenase and found to inhibit leukotrienes (LTB4 , LTC4, LTD4 , and LTE4) formation and well-known for the effective treatment of asthma. Rapid, economical and simple ‘Zero order UV-spectrophotometry’ and ‘First order derivative UV-spectrophotometry’ have been developed for estimation zileuton in bulk and in-house tablets. Zileuton showed maximum absorbance at 258.4 nm in 0.01M NaOH. For Zero order UV-spectrophotometric method (Method I), two wavelengths 243.4 nm and 271.0 nm were selected for the determination of area under curve (AUC). In First

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Alvi, Shahabuddin N., Mehul N. Patel, Prakash B. Kathiriya, Bhavna A. Patel, and Shraddha J. Parmar. "Simultaneous Determination of Prasugrel and Aspirin by Second Order and Ratio First Order Derivative Ultraviolet Spectrophotometry." Journal of Spectroscopy 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/705363.

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Two simple, accurate, and precise UV derivative spectrophotometric methods for the simultaneous determination of Prasugrel and Aspirin in synthetic mixture form have been developed. The first method involves measurement of second order derivative spectra of Prasugrel and Aspirin. The zero crossing wavelengths 267.62 nm and 252.40 nm were selected for estimation of Prasugrel and Aspirin, respectively. In the second method, the first order derivatives of ratio spectra were calculated and used for the determination of Prasugrel and Aspirin by measuring the peak intensity at 268 nm and 290 nm, res

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Khan, Zamir G., Amod S. Patil, and Atul A. Shirkhedkar. "Estimation of Tadalafil Using Derivative Spectrophotometry in Bulk Material and in Pharmaceutical Formulation." International Journal of Spectroscopy 2014 (May 21, 2014): 1–6. http://dx.doi.org/10.1155/2014/392421.

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Four simple, rapid, accurate, precise, reliable, and economical UV-spectrophotometric methods have been proposed for the determination of tadalafil in bulk and in pharmaceutical formulation. “Method A” is first order derivative UV spectrophotometry using amplitude, “method B” is first order derivative UV spectrophotometry using area under curve technique, “method C” is second order derivative UV spectrophotometry using amplitude, and “method D” is second order derivative UV spectrophotometry using area under curve technique. The developed methods have shown best results in terms of linearity,

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Ayoub, Bassam M., Ramzia I. El-Bagary, and Ehab F. Elkady. "Spectroflourometric and Spectrophotometric Methods for the Determination of Sitagliptin in Binary Mixture with Metformin and Ternary Mixture with Metformin and Sitagliptin Alkaline Degradation Product." International Journal of Biomedical Science 7, no. 1 (2011): 62–69. http://dx.doi.org/10.59566/ijbs.2011.7062.

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Simple, accurate and precise spectroflourometric and spectrophotometric methods have been developed and validated for the determination of sitagliptin phosphate monohydrate (STG) and metformin HCL (MET). Zero order, first derivative, ratio derivative spectrophotometric methods and flourometric methods have been developed. The zero order spectrophotometric method was used for the determination of STG in the range of 50-300 μg mL-1. The first derivative spectrophotometric method was used for the determination of MET in the range of 2-12 μg mL-1 and STG in the range of 50-300 μg mL-1 by measuring

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Salem, Maissa Y., Nesrin K. Ramadan, Azza A. Moustafa, and Mohamed G. El-Bardicy. "Stability-Indicating Methods for the Determination of Disopyramide Phosphate." Journal of AOAC INTERNATIONAL 89, no. 4 (2006): 976–86. http://dx.doi.org/10.1093/jaoac/89.4.976.

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Abstract Four methods were developed for the determination of intact disopyramide phosphate in the presence of its degradation product. In the first and second methods, third-derivative spectrophotometry and first derivative of the ratio spectra were used. For the third-derivative spectrophotometric method, the peak amplitude was measured at 272 nm, while for the derivative ratio spectrophotometric method, disopyramide phosphate was determined by measuring the peak amplitude at 248 and 273 nm. Both methods were used for the determination of disopyramide phosphate in the concentration range 12.

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Gabriel, Jiří, Ladislav Homolka, and Roman Krejčí. "A spectrophotometric assay of Indulin C - A potential new substrate for determination of lignin-degrading abilities of microorganisms." Collection of Czechoslovak Chemical Communications 55, no. 7 (1990): 1866–72. http://dx.doi.org/10.1135/cccc19901866.

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A basic spectrophotometric study of a commercially produced sodium salt of Kraft lignin (Indulin C) was performed. The method of quantitative determination of Indulin C based on its absorbance at 276 nm has been found to be applicable. The spectra were also studied by means of derivative UV-spectrophotometry, which is recommended for theoretical studies of electronic spectral behaviour of lignins and lignin model compounds. Linear dependences were found between Indulin C concentration and the second derivative of spectrum at 250 nm and 276 nm. Both methods were used for determining the lignin

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Rohilla, Rajni, and Usha Gupta. "Simultaneous Determination of Cobalt (II) and Nickel (II) By First Order Derivative Spectrophotometry in Micellar Media." E-Journal of Chemistry 9, no. 3 (2012): 1357–63. http://dx.doi.org/10.1155/2012/739891.

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A first-derivative spectrophotometry method for the simultaneous determination of Co (II) and Ni (II) with Alizarin Red S in presence of Triton X-100 is described. Measurements were made at the zero-crossing wavelengths at 549.0 nm for Co (II) and 546.0 nm for Ni (II). The linearity is obtained in the range of 0.291- 4.676 μg/ml of Ni (II) and 0.293- 4.124 μg/ml of Co (II) in the presence of each other by using first derivative spectrophotometric method. The possible interfering effects of various ions were studied. The validity of the method was examined by using synthetic mixtures of Co (II)

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G., Ramanjaneyulu, Raveendra Reddy P., Krishna Reddy V., and Sreenivasulu Reddy T. "Direct and derivative spectrophotometric determination of cobalt with 5-bromosalicylaldehydethiosemicarbazone." Journal of Indian Chemical Society Vol. 80, Aug 2003 (2003): 773–76. https://doi.org/10.5281/zenodo.5836488.

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Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515 003, India <em>Manuscript received 16 June 1999, revised 11 February 2003, accepted 12 March 2003</em> A simple and sensitive spectrophotometric method is developed for the determination of cobalt in aqueous DMF medium. The metal ion forms a brown coloured complex with 5-bromosalicylaldehydethiosemicarbazone (5-BSAT) in acidic medium. The complex shows absorption maximum at 410 nm. Beer's law is obeyed in the range 0.29-5.89<em>µ</em>g ml<sup>-1</sup> of cobalt(ll). A method for the determination of cobalt by thir

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Ferreira, Sérgio L. C., Bruno F. Santos, Jailson B. de Andrade, and Antonio C. Spinola Costa. "Spectrophotometric and derivative spectrophotometric determination of nickel with hydroxynaphthol blue." Microchimica Acta 122, no. 1-2 (1996): 109–15. http://dx.doi.org/10.1007/bf01252412.

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Ferreira, Sérgio L. C., Neide O. Leite, Alailson F. Dantas, Jailson B. de Andrade, and A. C. Spinola Costa. "Spectrophotometric and derivative spectrophotometric determination of aluminium with Hydroxynaphthol Blue." Talanta 41, no. 10 (1994): 1631–36. http://dx.doi.org/10.1016/0039-9140(94)e0088-9.

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Tejaswini, Kande, Dhekale Pallavi, Khatal Supriya, and Borude Priyanka. "Development and Validation of Analytical Methods for Simultaneous Spectrophotometric Determination of Pioglitazone and Glimepiride by Derivative Method." International Journal of Trend in Scientific Research and Development 4, no. 1 (2019): 822–25. https://doi.org/10.5281/zenodo.3609706.

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A simple, rapid UV Visible spectrophotometric method for the quantification of Pioglitazone hydrochloride and Glimepiride in bulk drug and tablet formulation was developed and validated. UV Visible spectrophotometric methods have been developed for the Derivative Spectrophotometric Method, of Pioglitazone and glimepiride in bulk and pharmaceutical dosage forms. the sampling wavelengths selected are 210 nm and 218 nm over the concentration ranges of 1.5 7.5 Âµg ml and 0.2 1.0 Âµg ml for pioglitazone and glimepiride respectively. Tejaswini Kande | Pallavi Dhekale | Supriy

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Abbas, Ruba Fahmi. "Two Derivative Spectrophotometric Methods for the Simultaneous Determination of 4-AminoAntipyrine in Presence of Its Acidic Products." Ibn AL- Haitham Journal For Pure and Applied Science 31, no. 1 (2018): 114. http://dx.doi.org/10.30526/31.1.1859.

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Simple, economic and sensitive mathematical spectrophotometric methods were developed for the estimation 4-aminoantipyrine in presence of its acidic product. The estimation of binary mixture 4-aminoantipyrine and its acidic product was achieved by first derivative and second derivative spectrophotometric methods by applying zero-crossing at (valley 255.9nm and 234.5nm) for 4-aminoantipyrine and (peak 243.3 nm and 227.3nm) for acidic product. The value of coefficient of determination for the liner graphs were not less than 0.996 and the recovery percentage were found to be in the range from 96.

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Fahmi Abbas, Ruba. "Two Derivative Spectrophotometric Methods for the Simultaneous Determination of 4-AminoAntipyrine in Presence of Its Acidic Products." Ibn AL- Haitham Journal For Pure and Applied Science 31, no. 2 (2018): 86. http://dx.doi.org/10.30526/31.2.1960.

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Simple, economic and sensitive mathematical spectrophotometric methods were developed for the estimation 4-aminoantipyrine in presence of its acidic product. The estimation of binary mixture 4-aminoantipyrine and its acidic product was achieved by first derivative and second derivative spectrophotometric methods by applying zero-crossing at (valley 255.9nm and 234.5nm) for 4-aminoantipyrine and (peak 243.3 nm and 227.3nm) for acidic product. The value of coefficient of determination for the liner graphs were not less than 0.996 and the recovery percentage were found to be in the range from 96.

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SAAD ANTAKLI, LEON NEJEM, and MOUSTAFA ALABO JOUMAA. "Simultaneous Determination Of Atenolol And Hydrocholrothiazide In Tablets Formulation By Derivative Spectrometry." JOURNAL OF ADVANCES IN CHEMISTRY 17 (September 10, 2020): 73–79. http://dx.doi.org/10.24297/jac.v17i.8808.

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The derivative spectrophotometric method was developed and applied for the simultaneous determination of Atenolol (ATE) and Hydrochlorothiazide (HCT) in Tablets formulations. The first derivative spectrophotometric (1DS) method was applied for the determination of (ATE) and (HCT), respectively. (ATE) was determined at 271.9 nm (1D 271.9) and (HCT) was determined at 279.3 nm (1D 279.3). Linearity showed a good correlation coefficients R2 = 0.9994 and R2 = 0.9989 for (ATE) and (HCT), respectively. Linearity ranges were (10 – 280)

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Gackowski, Marcin, Marcin Koba, Katarzyna Mądra-Gackowska, and Stefan Kruszewski. "Comparison of high-performance thin layer chromatography/UV-densitometry and UV-derivative spectrophotometry for the determination of trimetazidine in pharmaceutical formulations." Acta Pharmaceutica 69, no. 3 (2019): 413–22. http://dx.doi.org/10.2478/acph-2019-0028.

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Abstract New methods for assaying trimetazidine dihydrochloride on the basis of thin layer chromatography and spectrophotometry are proposed and compared in the paper. In HPTLC/UV-densitometry, separation is achieved by using a mobile phase composed of ammonia-methanol (30:70, V/V) on silica gel HPTLC plates F254. Quantification using a non-linear calibration curve is accomplished by densito-metric detection at 230 nm. Derivative spectrophotometric determination of trimetazidine dihydrochloride is carried out from the fourth derivative of the absorbance at 233 nm in peak-zero mode. Statistical

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Abdulameer, Sarah S., and Khaleda H. Al-Saidi. "Simultaneous determination of amoxicillin and potassium clavulanate antibiotics in pharmacueutical sample using derivative spectrophotometric method." Journal of Biotechnology Research Center 5, no. 3 (2011): 49–60. http://dx.doi.org/10.24126/jobrc.2011.5.3.184.

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Derivatives spectrophotometric techniques were developed for the determination of Amoxicillin Trihydrate (Amox) with Potassium Clavulanate (PC) antibiotic binary mixtures. The simultaneous determination of these compounds was accomplished by derivative (1D, 2D and 3D) spectrophotometric technique and applying zero-crossing technique used for determination of (Amox) and (PC) in tablets. The second order derivative absorption spectra at valley λ=299 nm were used for (Amox) and also the second order derivative spectra at peak λ=239.5 nm were used for (PC). No interferences were found between both

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Maczka, Paulina, Anna Gumieniczek, Justyna Galeza, and Rafal Pietras. "Zero crossing and ratio spectra derivative spectrophotometry for the dissolution tests of amlodipine and perindopril in their fixed dose formulations." Current Issues in Pharmacy and Medical Sciences 27, no. 2 (2014): 113–17. http://dx.doi.org/10.2478/cipms-2014-0027.

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Abstract Dissolution tests of amlodipine and perindopril from their fixed dose formulations were performed in 900 mL of phosphate buffer of pH 5.5 at 37°C using the paddle apparatus. Then, two simple and rapid derivative spectrophotometric methods were used for the quantitative measurements of amlodipine and perindopril. The first method was zero crossing first derivative spectrophotometry in which measuring of amplitudes at 253 nm for amlodipine and 229 nm for perindopril were used. The second method was ratio derivative spectrophotometry in which spectra of amlodipine over the linearity rang

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Bonfilio, Rudy, Lívia Botacini Favoretto, Gislaine Ribeiro Pereira, Roberta de Cássia Pimentel Azevedo, and Magali Benjamim de Araújo. "Comparative study of analytical methods by direct and first-derivative UV spectrophotometry for evaluation of losartan potassium in capsules." Brazilian Journal of Pharmaceutical Sciences 46, no. 1 (2010): 147–55. http://dx.doi.org/10.1590/s1984-82502010000100017.

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Losartan potassium is an antihypertensive non-peptide agent, which exerts its action by specific blockade of angiotensin II receptors. The aim of the present study was the validation and application of analytical methods for the quality control of losartan potassium 50 mg in pharmaceutical capsules, using direct and first-derivative UV spectrophotometry. Based on losartan potassium spectrophotometric characteristics, a signal at 205 nm of the zero-order spectrum and a signal at 234 nm of the first-derivative spectrum, were found adequate for quantification. The results were used to compare the

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Erk, Nevin. "DERIVATIVE RATIO SPECTROPHOTOMETRY AND DIFFERENTIAL DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF ISONIAZID AND PYRIDOXINE HYDROCHLORIDE IN DOSAGE FORMS." Spectroscopy Letters 34, no. 6 (2001): 745–61. http://dx.doi.org/10.1081/sl-100107897.

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Huda Ghalib Salman. "Derivative Absorption Spectrophotometry for the determination of Bambermycin and Paracetamol in Pharmaceutical Drugs." Journal of the College of Basic Education 20, no. 86 (2023): 1057–64. http://dx.doi.org/10.35950/cbej.v20i86.9747.

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Derivative spectrophotometric techniques were used for the determination of bambermycin with paracetol binary mixture. Simultaneous determination of these compounds was accomplished by derivative (1D,2D, and 3D) spectrophotometric technique and applying zero-crossing technique used for determination of bambermycin and paracetol in capsules (samera, India). The second order derivative absorption spectra at vally λ=235 nm were used for bambermycin and also the second order derivative absorption spectra at λ=268nm were used for paracetol . No interference were found between both constituents and

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Noon AA Kamil, Shaza W Shantier, and Elrasheed A Gadkariem. "Torsemide Analysis Using Derivative Spectrophotometric Methods." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1847–52. http://dx.doi.org/10.26452/ijrps.v11ispl4.4388.

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An accurate stability-indicating method has been developed for the analysis of Torsemide (TOR) in bulk and pharmaceutical dosage forms. The methods used the zero-order spectrum (0D) of TOR aqueous solution (measured at 285 nm) and the instrumentally differentiated first (1D) and second (2D) derivative spectra (measured at 311 nm and 282 nm, respectively). The effect of light, acid (HCL) and alkali (NaOH) on the stability of TOR were studied using the new methods. ICH guidelines were used to validate the new methods. Regression analysis of Beer's plots showed a good correlation coefficient not

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Wahbi, Abdel-Aziz M., and Arafat M. Al-julani. "First Derivative Spectrophotometric Determination of Phenytoin." Analytical Letters 18, no. 11 (1985): 1375–80. http://dx.doi.org/10.1080/00032718508066217.

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El-Yazbi, Fawzy A. "Second—Derivative Spectrophotometric Determination of Famotidine." Spectroscopy Letters 25, no. 7 (1992): 1011–21. http://dx.doi.org/10.1080/00387019208018211.

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In�s Toral, M., Pablo Richter, and Braulio Mu�oz. "Derivative spectrophotometric method for copper determination." Environmental Monitoring and Assessment 38, no. 1 (1995): 1–10. http://dx.doi.org/10.1007/bf00547122.

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Szumilo, Michal, Piotr Belniak, Regina Kasperek-Nowakiewicz, Ewelina Holody, and Ewa Poleszak. "Comparative dissolution studies on granules with acetaminophen and caffeine using the basket and paddle methods with simultaneous spectrophotometric determination of active substances." Current Issues in Pharmacy and Medical Sciences 32, no. 4 (2019): 219–24. http://dx.doi.org/10.2478/cipms-2019-0037.

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Abstract Acetaminophen and caffeine, popular therapeutic substances used to relieve pain or alleviate the symptoms of cold. The aims of the study were the comparison of granules, in terms of dissolution rate and moreover the development of spectrophotometric method to the simultaneous determination of both active pharmaceutical ingredients (APIs) in granules. The granules were tested by two pharmacopoeial methods of dissolution for solid dosage forms, and the dissolution profiles for each formulation were compared. A method of simultaneous determination of two medicinal substances by the doubl

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