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Dissertations / Theses on the topic 'Derivatives 5'

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Published: 2 June 2025
Last updated: 31 July 2025

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1

Aw, Leonard Kah Jin. "Some chemistry of 5-diazouracil and its derivatives." Thesis, City University London, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328892.

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2

Gao, Xuefeng Harmata Michael. "Oxidation & 1, 5-hydride shift of sulfoximine derivatives." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/6646.

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Title from PDF of title page (University of Missouri--Columbia, viewed on March 10, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Thesis advisor: Dr. Michael Harmata. Includes bibliographical references.
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3

Chornous, V. O. "5-carbofunctionalized imidazoles and their derivatives: synthesis and biomedical investigation." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/16859.

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4

Flynn, Bernard L. "The synthesis and palladium-catalysed coupling of 5-Trifluoromethanesulfonyluridine derivatives /." Title page, contents and abstractn only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phf648.pdf.

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5

Borssum, Waalkes Marjan van. "Lipophilic derivatives of 5-fluoro-2'-deoxyuridine as liposomal anticancer agents." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1992. http://irs.ub.rug.nl/ppn/292987617.

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6

Kayalar, Metin. "Synthesis Of 1,2,3,5-tetrasubstituted Pyrrole Derivatives Via 5-exo-dig Type Cyclization And Stereoselective Functionalisation Of Ferrocene Derivatives." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12605757/index.pdf.

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ABSTRACT SYNTHESIS OF 1,2,3,5-TETRASUBSTITUTED PYRROLE DERIVATIVES VIA 5-EXO-DIG TYPE CYCLIZATION AND STEREOSELECTIVE FUNCTIONALISATION OF FERROCENE DERIVATIVES Metin Kayalar M.S., Department of Chemistry Supervisor: Prof. Dr. Ayhan S. Demir January 2005, 102 pages A convenient and new method for the synthesis of 1,2,3,5-tetrasubstituted pyrrole derivatives starting from 1,3,-dicarbonyl compounds through acid catalyzed cyclization reaction is described. Alkylation of 1,3-dicarbonyl compound with propargyl bromide followed by one step cyclization with the introduction of primary amines in
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7

Erdtman, Edvin. "5-Aminolevulinic acid and derivatives thereof : properties, lipid permeability and enzymatic reactions." Doctoral thesis, Örebro universitet, Akademin för naturvetenskap och teknik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-9951.

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5-aminolevulinic acid (5-ALA) and derivatives thereof are widely usedprodrugs in treatment of pre-malignant skin diseases of the cancer treatmentmethod photodynamic therapy (PDT). The target molecule in 5-ALAPDTis protoporphyrin IX (PpIX), which is synthesized endogenously from5-ALA via the heme pathway in the cell. This thesis is focused on 5-ALA,which is studied in different perspectives and with a variety of computationalmethods. The structural and energetic properties of 5-ALA, itsmethyl-, ethyl- and hexyl esters, four different 5-ALA enols, and hydrated5-ALA have been investigated using Q
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8

Sullivan, Shannon M. "Synthesis of 2,4-disubstituted pyrimidine derivatives as potential 5-HT7 receptor antagonist." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-05052008-153400/.

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Thesis (M.S.)--Georgia State University, 2008.<br>Title from file title page. Lucjan Strekowski, committee chair; A.L. Baumstark, Gabor Patonay, Doyle Barrow , committee members. Electronic text (68 p. : ill.) : digital, PDF file. Description based on contents viewed June 23, 2008. Includes bibliographical references (p. 42-430.
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9

Ireland, Alan C. "Metabolism and mode of action of 5-aminosalicylic acid and its derivatives." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236211.

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10

Jorge, Salomão Dória. "Síntese e avaliação da atividade antibacteriana de derivados 5-metilsulfonil-2-tiofilidênicos e de derivados 5(6)-benzofuroxânicos frente a cepas padrão e multi-resistente de Staphylococcus aureus." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-20062007-143516/.

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A emergência de resistência microbiana é um desafio para microbiologistas, médicos, órgãos de saúde pública e para a indústria farmacêutica. Passado três décadas, patógenos gram-positivos, principalmente Staphylococcus aureus, têm desenvolvido cada vez mais resistência a vários antibióticos devido ao uso extensivo nos hospitais e na comunidade. Este desenvolvimento aconteceu em um período em que poucas novas classes de antibióticos tenham sido identificadas, ressaltando a necessidade urgente de novos agentes antimicrobianos. A modificação molecular tem se mostrado como estratégia bastante prom
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11

Jadhav, V. H. "New 2-arylidene tetralone, 5-hydroxycyclopentenone derivatives with potential anticancer activity; furanone and azole derivatives as antifungal agents and some organic transformations." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2007. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2611.

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12

Oliveira, Marcelio. "Synthesis and Evaluation of N6,5'-Bis-Ureido-5'-Amino-5'-Deoxyadenosine Derivatives: Novel Nucleosides with Antiproliferative and Protein Kinase Binding Activities." Diss., CLICK HERE for online access, 2009. http://contentdm.lib.byu.edu/ETD/image/etd3231.pdf.

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13

Taylor, Emma Louise. "Studies into the Production of Protoporphyrin IX from 5-Aminolaevulinic Acid and its Derivatives." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491707.

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Aminolaevulinic acid-photodynamic therapy (ALA-PDT) has become widely used for the treatment of a range of premalignant, malignant and nonmalignant conditions, particularly in dermatology. Exogenous administration ofALA induces accumulation of endogenous porphyrins, most notably protoporphyrin IX. These porphyrins can be photoactivated by a specific wavelength of light, which, in the presence of molecular oxygen, results in the generation of reactive oxygen species and thus localised cell death. I ,I 11 Despite promising results, ALA-PDT has proved to have a number of limitations, most of whic
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14

Yang, Min. "Synthesis of 5 thioglucose derivatives in the carbohydrate metabolic pathways in lactic acid bacteria." Thesis, University of Huddersfield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274227.

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15

Rodríguez, García Bárbara. "Prussian blue derivatives as smart materials for technological applications." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/456996.

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Els hexacianometalats de metalls de transició, isoestructurals amb el blau de Prussia (PB), son un tipus molt important de composts de coordinació inorgànics. En general, son no estequioméstrics i de valència mixta, lo que els converteix en materials amb una química molt rica i versàtil i dels que se han descrit múltiples propietats i aplicacions. En aquesta tesi, explorem algunes modificacions d’aquests materials per abordar alguns reptes tecnològics. En primer lloc, explorem la capacitat catalítica dels anàlegs de cobalt ferro (CoHFe) en la reacció d’oxidació d’aigua. Comprovem que, a més a
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16

Segado, Centellas Mireia. "Beyond Jablonski diagrams in organic systems: ab initio studies of substituted benzene derivatives." Doctoral thesis, Universitat Rovira i Virgili, 2011. http://hdl.handle.net/10803/51757.

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En aquesta tesis s’estudia la fotoquímica i la fotofísica d'alguns compostos orgànics fotosensibles derivats del benzè. Es centra principalment en els fenòmens de la fotosesitització i de la transferència intramolecular de càrrega. L’estudi es desenvolupa amb mètodes teòrics ab initio per determinar els mecanismes dels processos estudiats. Per una descripció detallada d’aquests mecanismes és necessari caracteritzar la naturalesa dels estats involucrats, les estructures de les espècies que intervenen en la reactivitat i determinar de manera precisa les seves energies. En aquest treball s’ha es
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17

Radzey, Hanna Agnes. "Synthesis of fluorescent toxin and nucleotide derivatives to specifically address membrane proteins." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://hdl.handle.net/11858/00-1735-0000-0022-6055-5.

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18

Barus, M. M. "Search for antimicrobial agents among functional derivatives of 3-[5-(4-nitrophenyl) -2-furyl] -4-pyrazolecarbaldehydes." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18517.

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19

Bratenko, M. K. "Synthesis of potentially biologically active functional derivatives of 3- [5- (4-nitrophenyl) -2-furyl] -4-pyrazolecarbaldehydes." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18518.

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20

Conde, Amanda Solis. "Synthesis of 5-methyl-3-phenyl-1,3,4-oxadiazol-2(3H)-one derivatives by electrophilic aromatic substitution." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1547584724393162.

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21

Shelton, Jadd R. "Synthesis and Biological Evaluation of Various Derivatives of a Broad-Spectrum Anticancer Nucleoside." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3743.

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Recently the Peterson lab discovered a promising anticancer adenosine derivative-- 2´,3´-bis-O-tert-butyldimethylsilyl-5´-deoxy-5´-[N-(methylcarbamoyl)amino]-N6-(N-phenylcarbamoyl)adenosine. This compound showed selective toxicity against human colon cancer cells in vitro with LC50's = 6--10 µM. It was hypothesized that the lead compound exerted its cytotoxic effects by interacting with a protein kinase. A systematic Structure Activity Relationship (SAR) was undertaken in an attempt to increase the kinase-binding affinity of the lead compound. Many regions of the lead compound were examined: t
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22

Xia, Zuping. "Design, synthesis and biological evaluation of butanoate, retinoate and bis(2,2,2-trichloroethyl)phosphate derivatives of 5-fluoro-2'-deoxyuridine and 2',5-difluoro-2'-deoxyuridine." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0012/NQ29127.pdf.

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23

Pambi, Daniel. "A Laser Raman spectroscopic study of the pH induced structural changes in Guanosine-5’ monophosphate and its derivatives." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1988. http://digitalcommons.auctr.edu/dissertations/3086.

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The purpose of this study was to determine the protonation sites in guanosine-5'-monophosphate (5'-GMP), and to correlate the ease of protonation with the chemical nature and composition of substituent groups. The laser Raman spectra of 5'-GMP, 7-methyl-guanosine-5'-monophosphate (m7-GMP), and 8-bromoguanosine-5'-monophosphate (8-Br-GMP) at various pH and pD values were recorded with a Spex Ramalog-6 spectrometer. Based on the spectral changes observed in these studies, the preferred order of protonation sites for 5'-GMP and 8-Br-GMP is N7, 06 and N3. In the case of m7-GMP, the preferred sites
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24

Piper, Colin. "Synthesis and structural study of functionally substituted #eta#'5-cyclopentadienyl derivatives of transition and main group metals." Thesis, Coventry University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281883.

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25

Alipour, Siamak. "Conversion of Cellulose from Plant Biomass to 5-(hydroxymethyl)furfural (HMF) and its Derivatives in Ionic Liquid Media." University of Toledo / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1429780958.

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26

Li, Ying 1972 Mar 31. "The effects of cyclic guanosine 3', 5'-monophosphate analog on protein accumulation in adult rat cardiomyocytes in vitro /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101863.

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Cyclic guanosine 3', 5'-monophosphate (cGMP) has recently emerged as an endogenous regulator for controlling or reversing cardiac hypertrophy. Increased protein accumulation is a key feature of cardiac hypertrophy; thus, our study investigates the effects of a cGMP analog on protein accumulation in primary culture of adult rat cardiomyocytes and dissects out the mechanisms involved. We confirmed that a cGMP analog, 8-bromo-cGMP, inhibits phenylephrine (PE)-increased accumulation of newly synthesized proteins in cultured adult rat ventricular cardiomyocytes. Firstly, we have obtained data showi
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27

Pasin, Juliana Saibt Martins. "Atividade antipirética e antiinflamatória de derivados 5-trifluormetil-4,5-diidro-1H-1-carboxiamida pirazol em ratos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/28004.

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A febre é um aumento regulado da temperatura corporal central, caracterizada por uma alteração no centro termorregulatório, a qual resulta da interação entre o sistema nervoso central e o imunológico. Enquanto a febre caracteriza lesão celular, infecção e inflamação, ela tem sido considerada o mais importante componente da resposta de fase aguda. Embora existam evidências de que a febre aumenta a defesa do hospedeiro, alguns estudos têm sugerido que o aumento da temperatura central a níveis febris pode ser prejudicial. Portanto, nas situações clínicas nas quais os riscos associados com a febre
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28

Gaivelytė, Kristina. "5-nitrofuraldehido darinių antimikrobinio aktyvumo tyrimas, toksiškumo, farmakokinetikos ir struktūros aktyvumo ryšio įvertinimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100621_093138-22354.

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5-nitrofuraldehido darinių antimikrobinio aktyvumo tyrimas, toksiškumo, farmakokinetinių savybių ir struktūros aktyvumo ryšio įvertinimas. K. Gaivelytės magistro baigiamasis darbas. Moksliniai vadovai: dr. V. Petrikaitė, dr. J. Šarlauskas, prof. habil. dr. A. Pavilonis; Kauno medicinos universiteto, Farmacijos fakulteto, Vaistų chemijos katedra. Kaunas, 2010. Darbo tikslas – įvertinti 5-nitrofuraldehido darinių struktūros įtaką jų antimikrobiniam aktyvumui ir parinkti perspektyviausius antimikrobinius junginius tolimesniems tyrimams. Tyrimo metodai. Junginių antimikrobinio aktyvumo prognozė at
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29

Oberoi, Sonia. "Synthesis and Characterization of Thin films of Novel Functionalised 2,5-Dithienylpyrrole Derivatives on Oxide Substrates." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1118754022012-45347.

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Conducting polymers find variety of application in many areas in microelectronics. PPY and PT are among the most extensively studied intrinsically conducting polymers. The problem of poor adhesion of the electrochemically deposited conducting polymers was the main focus of this work. This easy peeling of the PPY layer from the oxide substrate was circumvented by design of novel adhesion promoters, which compatibilise the two incompatible surfaces- the polymer film and the oxide substrate. The first part of the research was focused on the synthesis of different classes of adhesion promoters. Th
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30

Bhattarai, Sanjay [Verfasser]. "Synthesis and structure-activity relationships of alpha,beta-methylene-ADP derivatives: potent and selective ecto-5′-nucleotidase inhibitors / Sanjay Bhattarai." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1077290330/34.

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31

Bhat, Shreesha V. "Synthesis of 1,2,4 oxadiazol-5-imine, 1,2,4-triazol-3-imine and derivatives : a substituted cyanamide-based strategy for heterocycle synthesis." Thesis, University of Lincoln, 2017. http://eprints.lincoln.ac.uk/28632/.

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Considering the importance of nitrogen-rich heterocycles in drug discovery, a novel strategy towards heterocycle synthesis was envisioned using cyanamide chemistry. Synthesis which involve mild conditions, avoids multi-step sequence and non-toxic reagents are desirable for generation of large combinatorial libraries of drug molecules. We envisaged that the NCN linkage of the cyanamide as well as the concomitant use of the nucleo-and electrophilic centres of the cyanamide could provide a novel synthetic route towards nitrogen heterocycles. The first part (Ch-2) constitute the bulk of the thesis
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32

Roberts, Thomas David. "Novel ligands based on 2,6-di(1H-pyrazol-5-yl)pyridine derivatives and applications in spin crossover and transfer hydrogenation complexes." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/9418/.

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This thesis is an account of the synthesis of novel iron(II) and ruthenium(II) complexes using 2,6-di(1H-pyrazol-3-yl)pyridine based ligands and their efficacy as spin crossover complexes and transfer hydrogenation catalysts respectively. Chapter 1 is an introduction to the spin crossover and transfer hydrogenation detailing significant literature examples, important influencing factors and applications. Chapter 2 details the synthetic pathways towards all novel ligands used in this work, including numerous attempted pathways and problems which were overcome. Chapter 3 describes the properties
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33

Leleu, Ludovic. "Elaboration de librairies de molécules structurellement diversifiées à partir du squelette de l'acide kojique par des méthodes de synthèse micro-ondes et de flux continu." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEC005/document.

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La structure de l’acide kojique et sa réactivité permet d’effectuer des transformations conduisant à la synthèse de composés polycycliques différents et structurellement très diversifiés. Ces hétérocycles sont obtenus en plusieurs étapes en s’appuyant sur des réactions typiques telles que des cycloadditions [5+2], Diels-Alder, [5+2]/[4+2] tandem, des réactions à 3 composantes ou encore l’utilisation de lithiens. L’utilisation d’appareillages spécifique tels que un réacteur micro-ondes et un synthétiseur en flux continue permettent l’obtention des molécules ciblées d’une façon plus spécifique e
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34

Queiroz, Ronaldo Bezerra de. "Evidências pré-clínicas da ação antinociceptiva do 3-fenil-5-(4-etilfenil)-imidazolidina-2,4-diona em estudos psicofarmacológicos." Universidade Federal da Paraí­ba, 2011. http://tede.biblioteca.ufpb.br:8080/handle/tede/6867.

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Made available in DSpace on 2015-05-14T13:00:17Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 848309 bytes, checksum: ccc0950ac2cd6a78a38eac3b62f6aa2c (MD5) Previous issue date: 2011-02-28<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Imidazolidine derivatives are synthetic products with many different therapeutic applications. Many imidazolidine derivatives have pharmacological properties at the level of the CNS, such as phenytoin, which is used in clinical practice as an anticonvulsant. However, this also works effectively in the treatment of neuropathic
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35

Altundas, Abdullah Bilal. "Synthesis of XZH-5 Derivatives as Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) and Synthesis of π-Extended Tetraphenylporphyrins". Miami University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1473201129.

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36

Basili, Serena. "Computational Approaches for the Rational Design of Novel Topoisomerase I Poisons as Potential Anticancer Drugs." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426128.

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Topoisomerase I (TopoI) is an essential DNA-targeting enzyme which alters the supercoiling of DNA through a concerted process of breaking and rejoining of a DNA strand, thereby controlling the DNA topology required for replication and transcription. TopoI mediates relaxation of supercoiled DNA by creating a transient single-strand break in the DNA duplex that originates from a transesterification reaction involving a nucleophilic attack by the active-site tyrosine (Tyr723) hydroxyl group on a DNA phosphodiester bond situated at the site of cleavage. The resulting 3'-phosphotyrosine enzyme-DNA
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37

Menezes, Camila Braz. "Nucleosídeo trifosfato difosfohidrolase e ecto-5'-nucleotidase de Trichomonas vaginalis : metabolismo dos nucleotídeos e nucleosídeo de guanina, efeito na citotoxicidade e modulação da atividade anti-T. vaginalis de floroglucinois." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/149487.

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Trichomonas vaginalis é o protozoário flagelado que parasita o sistema urogenital humano causando a tricomoníase, a doença sexualmente transmissível não viral mais comum no mundo, sendo registrados aproximadamente 276 milhões de novos casos a cada ano. O sucesso da colonização das células hospedeiras e desenvolvimento da infecção envolve um complexo processo que culmina em citoaderência e citotoxicidade. Nucleotídeos e nucleosídeos são liberados para o espaço extracelular por células em situações de estresse ou lesão tecidual e desencadeiam seus efeitos sinalizadores através da ativação de pur
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38

Armoškaitė, Vilma. "Vietinio poveikio vaisto formų ir jontoforezės poveikio 5-aminolevulino rūgšties ir jos provaisto skvarbai į (pro) odą įvertinimas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140930_085150-30544.

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Siekiant pagreitinti 5-aminolevulino rūgšties (5-ALA) skvarbą į (pro) odą ir sudaryti terapines fotodinaminiam gydymui tinkamas jos koncentracijas, įvertinta 5-ALA ir naujo provaisto skvarba į (pro) odą iš įvairių vietinio poveikio vaisto formų. Atlikta naujo provaisto 2-(dimetilamino)-etil-5-amino-4-oksopentanoato (DMAE-ALA) sintezė, ištirtos jo charakteristikos. Nustatytas susintetinto provaisto stabilumas įvairių pH verčių buferiniuose vandeniniuose tirpaluose ir odos esterazių poveikyje, įrodytas provaisto tinkamumas pernašai į (pro) odą. Atlikti 5-ALA ir du teigiamus krūvius vaisto formoj
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39

Otrebska-Machaj, Ewa. "The search for new inhibitors of bacterial efflux pumps among amine derivates of 5-Arylidenehydantoin." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5010.

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L’objet de ces recherches était de trouver de nouveaux EPIs du système d’efflux AcrAB-TolC dans les groupes de dérivés d’amine de la 5-arylidenehydantoine et de la 5-arylideneimidazolone. Dans la première étape de recherche, 32 nouveaux dérivés ont été obtenus après modification de la structure lead P2.Un screening théorique du risque toxique et la prédiction des propriétés médicamenteuses des composés ont été réalisés en utilisant le programme OSIRIS qui calcule différentes propriétés médicamenteuses pertinentes basées sur la structure planaire de la molécule.Dans l’étape suivante de la reche
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Tang, Betty. "Synthesis of closomer derivatives of polyhedral boranes for use as drug delivery vehicles." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1779690201&sid=5&Fmt=2&clientId=48051&RQT=309&VName=PQD.

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41

Costal, Flavia Soares Louro. "Benfotiamina e Mito Q protegem ilhotas pancreáticas de rato em cultura dos efeitos pró-apoptóticos dos produtos finais de glicação avançada (AGEs)." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-24052012-161456/.

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A perda da função das células beta acelera a deterioração do controle metabólico em pessoas com diabetes tipo 2. Além da lipo- e da glicotoxicidade, os AGEs parecem contribuir para esse processo, promovendo a apoptose das ilhotas pancreáticas. Em outros tecidos, os AGEs interagem com seu receptor específico (RAGE), produzindo espécies reativas de oxigênio (ROS) e ativando o NF-kB. Para investigar o efeito temporal dos AGEs sobre a apoptose de ilhotas, bem como o potencial de compostos antioxidantes para diminuir danos causados pelos AGEs, ilhotas pancreáticas de ratos foram tratadas durante 24
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Marin, Julien. "Enantiopure monohydroxylated delta-lactams as precursors of glycosylated 4- and 5-hydroxylysine derivatives : Application to the synthesis of glycopeptides derived from type II collagen." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. https://publication-theses.unistra.fr/public/theses_doctorat/2003/MARIN_Julien_2003.pdf.

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La polyarthrite rhumatoi͏̈de (PR) est une maladie autoimmune gravement invalidante qui affecte plus de 0. 5% de la population mondiale. L'arthrite expérimentale au collagène (AEC) est le modèle murin le plus répandu pour l'étude de cette maladie. En 1994, le groupe de Holmdahl a démontré que l'épitope T immunodominant dans l'AEC correspondait à un glycopeptide dérivé du collagène de type II (CII). Des études ultérieures réalisées par Holmdahl en collaboration avec le groupe de Khilberg ont permis de mettre en évidence que ce peptide correspondant à la séquence CII(256-270) contenait une lysine
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Guo, Junhong. "Part I: Biological Activities and Cellular Metabolism of 4-Hydroxy-7-oxohept-5-enoate and 5-Hydroxy-8-oxo-6-octenoate LactonesPart II: Carboxyalkylpyrrole, Pentylpyrrole and 4-Oxo-heptanedioic Amide Derivatives of Ethanolamine Phospholipids and Proteins." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1467829630.

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Gnanabakthan, Naveen. "Understanding the basis of 5-Bromo-2'-deoxuridine teratogen specificity in organogenesis stage mouse embryos." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112624.

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5-Bromo-2'-deoxyuridine (BrdU), a thymidine analogue, is genotoxic and teratogenic. The exposure of mouse embryos to BrdU at doses that cause malformations induces oxidative stress and an embryonic stress response characterized by an increase in c-Fos dependent AP-1 DNA binding. The goal of this thesis was to test the hypothesis that development is disturbed at sites where BrdU is incorporated into DNA, triggering oxidative stress and c-Fos induction. Gestation day 9 CD-1 mice were treated with BrdU and embryos were obtained for immunolocalization of BrdU, 8-oxoguanine, a biomarker for oxidati
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Dejneka, S. Y., V. K. Svizhak та V. O. Chornous. "Search of substances with antimicrobial properties among the derivatives of 2,4-disubstitutive 3-(1-aryl-imidazole-5-іl)propen-1-ions and propane-1-ions". Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/12364.

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Becker, Luis Eduardo. "Efeito do paricalcitol e do calcitriol sobre a doença cardiovascular em camundongos uninefrectomizados ApoE -/-." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-10032008-111920/.

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O estudo investigou a influência do tratamento de 10 semanas com paricalcitol (0,1µg/kg 5x/semana) e calcitriol (0,03µg/kg 5x/semana) em modelo de aterosclerose espontânea utilizando camundongos ApoE -/- sham e uninefrectomizados (UNX). Resultados: a densidade capilar por comprimento no tecido cardíaco foi significativamente mais baixa nos animais UNX Controle quando comparados aos shams, o que não ocorreu nos animais UNX tratados com paricalcitol e calcitriol. Nas aortas, a relação parede/lúmen foi significativamente menor no grupo Sham Controle quando comparada à dos grupos UNX Controle e U
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Csatary, Erika Elizabeth. "Asymmetric Multicomponent Aza-Diels-Alder Reaction for Construction of Multicyclic Heterocycles and Development of XZH-5 Derivatives as Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3)." Miami University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=miami1435110305.

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Annibaletto, Julien. "L'alkylidène de l'acide de Meldrum comme plateforme utile en réaction multicomposés organocatalysée Catalytic enantioselective syntheses of isoxazolidin-5-ones C5‐disubstituted Meldrum's acid derivatives as platform for the organocatalytic synthesis of c3‐alkylated dihydrocoumarins." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMIR19.

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L’objectif de cette thèse a été d’accéder à des hétérocycles chiraux, les isoxazolidin-5-ones, par le biais d’une réaction multicomposés organocatalysée impliquant un intermédiaire très réactif qui est l’alkylidène de l’acide de Meldrum. A l’aide de nucléophiles atypiques dérivés d’urée et d’un nouvel organocatalyseur dérivé du Quinquina, nous sommes parvenus à développer la première version énantiosélective organocatalysée de la réaction multicomposés de Knoevenagel/aza-Michael/Cyclocondensation permettant d’accéder aux isoxazolidin-5-ones β-substituées énantioenrichies. Une version diastéréo
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Bersuder, Émilie. "Cadhérine atypique MUCDHL et maladies inflammatoires chroniques intestinales : implication dans leur pathogénie, l'évolution cancéreuse et la réponse au traitement par les dérivés 5-aminosalicylés." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ026.

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Les causes des Maladies Inflammatoire Chroniques Intestinales (MICI) restent mal comprises et il n’existe aucun traitement curatif. L’une des complications possibles des MICI est l’augmentation du risque de cancer colorectal (CCR). La cadhérine atypique MUCDHL pourrait être impliquée dans les MICI. Nous avons étudié le rôle de MUCDHL dans la pathogénie des MICI, ainsi que les mécanismes moléculaires qui restaurent son expression. Nous avons montré que l’expression de MUCDHL est diminuée dans la muqueuse intestinale inflammatoire. De plus, les 5-aminosalicylés, utilisés pour traiter les MICI et
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Gormen, Meral. "Synthesis Of Ferrocenyl Substituted Pyrazoles." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606358/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of pyrazoles with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted pyrazoles, such as 1-alkyl/aryl-5-ferrocenylpyr
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