Relevant bibliographies by topics / Derivatives of alpha-glucosidase inhibitors

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Derivatives of alpha-glucosidase inhibitors'

Author: Grafiati
Published: 5 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "Derivatives of alpha-glucosidase inhibitors"

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Nursamsiar, Nursamsiar, Marwati Marwati, Khairuddin Khairuddin, et al. "Isolation, characterization, and in vitro inhibitory activity of a new alpha-glucosidase inhibitor from Schleichera oleosa (Lour.) Oken leaves." Journal of Pharmacy & Pharmacognosy Research 13, no. 1 (2025): 140–51. http://dx.doi.org/10.56499/jppres24.1960_13.1.140.

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Context: The development of novel and potent alpha-glucosidase inhibitors from natural sources holds immense promise for treating diabetes. Aims: To identify the isolated compound, determine its inhibitory potency, explore its molecular interactions with the alpha-glucosidase receptor, and understand the role of specific structural features in its inhibitory activity. Methods: Research began with the isolation and identification of the new gallic acid derivative of the Schleichera oleosa leaf extract. The isolated compound (1) was characterized as 3,5-dihydroxy-4-methoxybenzoic acid using spec
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Field, R. A., A. H. Haines, E. J. T. Chrystal, and M. C. Luszniak. "Histidines, histamines and imidazoles as glycosidase inhibitors." Biochemical Journal 274, no. 3 (1991): 885–89. http://dx.doi.org/10.1042/bj2740885.

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This present study reports the ability of a range of derivatives of L-histidine, histamine and imidazole to act as inhibitors of sweet-almond β-glucosidase, yeast alpha-glucosidase and Escherichia coli β-galactosidase. The addition of a hydrophobic group to the basic imidazole nucleus greatly enhances binding to both the alpha- and β-glucosidases. L-Histidine (beta-naphthylamide (Ki 17 microM) is a potent competitive inhibitor of sweet-almond β-glucosidase as is omega-N-acetylhistamine (K1 35 microM), which inhibits the sweet-almond β-glucosidase at least 700 times more strongly than either ye
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Ankireddy, Ashok Reddy, Rambabu Gundla, Tuniki Balaraju, et al. "Quinazolin derivatives as emerging alpha-glucosidase inhibitors." European Journal of Chemistry 9, no. 4 (2018): 322–30. http://dx.doi.org/10.5155/eurjchem.9.4.322-330.1748.

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A series of C-7 substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine have been synthesized and biochemical assay was examined against α-glucosidase function inhibition activity. A structure activity and structure property relationship study was experimented to surface the new hit compound. This study led to the identification of C-7substituted quinazolines with minimum inhibitory concentrations (MICs) in the preffered micromolar range in addition with interesting physicochemical properties. Biological evaluation yielded eight analogs which rose with significant α-glucosidase inhib
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K, Gupta. "3D-QSAR Analysis and Molecular Docking Studies on 3-Arylcoumarin Derivatives as Potential α- Glucosidase Inhibitors". Medicinal Chemistry 10, № 6 (2020): 5. https://doi.org/10.5281/zenodo.10669459.

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α-glucosidase inhibitors (AGI) are the structural moieties that are found to be of utmost importance in the fields of pharmacy and which involves delaying the absorption of carbohydrates by blocking of alpha-glucosidase enzyme in the brush border of small intestine and plays an important role in constituting a promising therapeutic class against diabetic disease (Type II). In this study, the three-dimensional quantitative structure-activity relationship (3D-QSAR) and docking models were developed using Fujito-Ban analysis in VALSTAT software and Molegro Virtual Docker 6.0. The theoretica
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M, Heravi; Majid, M. Mohammadi-Khanaposhtani, H. Yahyavi та ін. "New Biscoumarin Derivatives as Potent α-Glucosidase Inhibitors: Synthesis, Biological Evaluation, Kinetic Analysis, and Docking Study". Polycyclic Aromatic Compounds 40, № 7 (2020): 915–26. https://doi.org/10.1080/10406638.2018.1509359.

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A new series of biscoumarin derivatives 3a&ndash;n were synthesized and evaluated for their &alpha;-glucosidase inhibitory activities. The reaction of the 4-aminocoumarin with benzaldehyde derivatives led to the formation of the title compounds in good yields. All the synthesized compounds showed potent &alpha;-glucosidase inhibitory activity with IC<sub>50</sub> ranging from 20.0 &plusmn; 0.7 to180.1 &plusmn; 0.8&nbsp;&micro;M, in comparison with acarbose as the standard drug (IC<sub>50</sub> = 750.0&nbsp;1.5&nbsp;&micro;M). Among the synthesized compounds, 3,3&#39;-(p-tolylmethylene)bis(4-am
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Bule, Mohammed Hussen, Roghaieh Esfandyari, Tadesse Bekele Tafesse, Mohsen Amini, Mohammad Ali Faramarzi та Mohammad Abdollahi. "Synthesis, Molecular Docking and α-Glucosidase Inhibitory Activity Study of 2,4,6-triaryl Pyrimidine Derivatives". Letters in Drug Design & Discovery 17, № 10 (2020): 1216–26. http://dx.doi.org/10.2174/1570180817666200103130536.

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Background: α-Glucosidase inhibitors hinder the carbohydrate digestion and play an important role in the treatment of diabetes mellitus. α-glucosidase inhibitors available on the market are acarbose, miglitol, and voglibose. However, the use of acarbose is diminishing due to related side effects like diarrhea, bloating and abdominal distension. Objectives: This study aimed to synthesize 2,4,6-triaryl pyrimidines derivatives, screen their α- glucosidase inhibitory activity, perform kinetic and molecular docking studies. Methods: A series of 2,4,6-triaryl pyrimidine derivatives were synthesized
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Abchir, Oussama, Meriem Khedraoui, Imane Yamari, et al. "Exploration of alpha-glucosidase inhibitors: A comprehensive in silico approach targeting a large set of triazole derivatives." PLOS ONE 19, no. 9 (2024): e0308308. http://dx.doi.org/10.1371/journal.pone.0308308.

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Background The increasing prevalence of diabetes and the side effects associated with current medications necessitate the development of novel candidate drugs targeting alpha-glucosidase as a potential treatment option. Methods This study employed computer-aided drug design techniques to identify potential alpha-glucosidase inhibitors from the PubChem database. Molecular docking was used to evaluate 81,197 compounds, narrowing the set for further analysis and providing insights into ligand-target interactions. An ADMET study assessed the pharmacokinetic properties of these compounds, including
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Ernawati, Teni, Maksum Radji, Muhammad Hanafi, Abdul Mun’im та Arry Yanuar. "Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents". Indonesian Journal of Chemistry 17, № 1 (2017): 151. http://dx.doi.org/10.22146/ijc.23572.

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This paper reviews biological activity of some cinnamic acid derivative compounds which are isolated from natural materials and synthesized from the chemical compounds as an agent of α-glucosidase inhibitors for the antidiabetic drug. Aegeline, anhydroaegeline and aeglinoside B are natural products isolated compounds that have potential as an α-glucosidase inhibitor. Meanwhile, α-glucosidase inhibitor class of derivatives of cinnamic acid synthesized compounds are p-methoxy cinnamic acid and p-methoxyethyl cinnamate. Chemically, cinnamic acid has three main functional groups: first is the subs
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Hernández, Brandón, María del Carmen Cruz, Omar Gómez, Elvia Becerra, Fabiola Eloisa Jiménez, and Aaron Mendieta. "Alpha-glucosidase and Alpha-amylase Inhibitors Derived from Naturally Occurring Prenylated Isoflavones." Journal of the Mexican Chemical Society 68, no. 1 (2024): 156–69. http://dx.doi.org/10.29356/jmcs.v68i1.2129.

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A series of prenylated isoflavones were synthesized to evaluate their inhibitory effect against α-glucosidase and α-amylase enzymes, analyzing the bioisosteric effect of the linear or cyclized prenyl moiety in these benzopyran derivatives. Compound 5a exhibited higher α-glucosidase inhibition (IC50 = 60.5 µM) and lower α-amylase inhibition (IC50 = 85.0 µM) compared to acarbose (IC50 = 527.5 µM for α-glucosidase and 20.1 µM for α-amylase). In contrast, prenylated isoflavone 5c showed higher inhibition in both enzymes (IC50 = 17.6 µM for α-glucosidase and 21.2 µM for α-amylase). This suggests th
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Ullah, Saeed, Salma Mirza, Uzma Salar, et al. "2-Mercapto Benzothiazole Derivatives: As Potential Leads for the Diabetic Management." Medicinal Chemistry 16, no. 6 (2020): 826–40. http://dx.doi.org/10.2174/1573406415666190612153150.

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Background: Results of our previous studies on antiglycation activity, and the noncytotoxicity of 2-mercapto benzothiazoles, encouraged us to further widen our investigation towards the identification of leads against diabetes mellitus. Methods: 33 derivatives of 2-mercapto benzothiazoles 1-33 were evaluated for in vitro α- glucosidase inhibitory activity. Mode of inhibition was deduced by kinetic studies. To predict the interactions of 2-mercapto benzothiazole derivatives 1-33 with the binding pocket of α-glucosidase enzyme, molecular docking studies were performed on the selected inhibitors.
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Dissertations / Theses on the topic "Derivatives of alpha-glucosidase inhibitors"

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Stanfield, Charles Freeman. "Synthesis of alpha-amino aldehydes as kallikrein inhibitors; synthetic methods for preparation of beta-substituted cysteine analogues." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184738.

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The first half of this dissertation describes the synthesis and biological activities of a series of amino aldehydes; which were derivatives of the basic amino acids, arginine, lysine and ornithine. The synthesis of the amino aldehydes was complicated by the difficulty of producing an intermediate oxidation state (the aldehyde) in the presence of two other functional groups (the α-amino, and the side chain functionality). The amino aldehydes were of biological interest due to the fact that they were inhibitors of the proteolytic enzymes called kallikreins. The kallikreins are known to be invol
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Dhanda, Anupma. "Novel carbocyclic purine derivatives at TNF- #alpha# inhibitors and novel polyamino acids for asymmetric epoxidation of enones." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367101.

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Bhattarai, Sanjay [Verfasser]. "Synthesis and structure-activity relationships of alpha,beta-methylene-ADP derivatives: potent and selective ecto-5′-nucleotidase inhibitors / Sanjay Bhattarai." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1077290330/34.

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Ntini, V. P. "Inhibitory capabilities of ten medicinal plants used by traditional healers on mammalian carbohydrate digesting enzymes (alpha-amylase and alpha-glucosidase)." Thesis, University of Limpopo (Turfloop Campus), 2013. http://hdl.handle.net/10386/1237.

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Thesis (M.Sc. (Biochemistry)) -- University of Limpopo, 2013<br>Diabetes mellitus is one of the fast growing chronic metabolic disorders throughout the world. It has become a life threatening disease and health burden. So far it can only be managed with commercial therapeutic agents, proper diet and exercise. People particularly from developing countries use medicinal plants to treat this condition. According to WHO, about 80% of the population in developing countries are dependable on medicinal plants. This prompted many researchers to explore the effectiveness and safety of these plants
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Aumand, Livia M. "A Studies towards the formation of asymmetric quaternary centres via radical allylation B Applications of chiral hydrazide organocatalysts to Diels-Alder, hydride reduction, and alpha-chlorination reactions C Studies directed towards the synthesis of potential HIV-1 reverse transcriptase inhibitors: 9-Alkylaryl TIBO derivatives." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/26843.

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In part A, the attempts at synthesizing quaternary centres via radical reactions are described. Using tartrate acetals as chiral auxiliaries, tertiary bromides were submitted to radical allylation conditions in an effort to form 1,3-dicarbonyl compounds 27 possessing an asymmetric quaternary centre at C2.* Part B describes the synthesis of chiral hydrazide 129 and its ability to catalyze the Diels-Alder reaction is examined. The application of chiral hydrazides 131 to the organocatalytic hydride reduction of alpha,beta-unsaturated aldehydes and the alpha-chlorination of aldehydes is also recou
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Shahzad, ul Hussan Syed. "Small ligand effectors of bio-macromolecules exploration of novel [alpha]-glucosidase inhibitors and NMR investigation of tRNAPhe-bound aminoglycosides /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975693700.

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Li, Yu-Ting, and 李雨亭. "Design and Synthesis of Inhibitors againstSARS Coronavirus:Ⅰ alpha-Hydroxy Amide and alpha-KetoamideⅡ Glycyrrhizin Derivatives." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/14948791934852301955.

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碩士<br>國立臺灣大學<br>化學研究所<br>94<br>The aim of this thesis is to discover the antiviral agents against severe acute respiratory syndrome coronavirus (SARS-CoV). This thesis consists of two parts: (i) synthesis of alpha-hydroxy amide and alpha-keto amide derivatives, and (ii) synthesis of glycyrrhetinic acid derivatives. The derivatives of alpha-hydroxy amide and alpha-keto amide, such as 12 and 13 were synthesized, in order to mimic the tetrahedral transition state in the hydrolysis of the peptide substrate catalyzed by the SARS-CoV main protease. The inhibition assays were carried out using a pept
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"Enantiospecific synthesis of valiolumine and its diastereoisomers from (-)-quinic acid." Chinese University of Hong Kong, 1994. http://library.cuhk.edu.hk/record=b5887291.

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Wan Leong Hang.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1994.<br>Includes bibliographical references (leaves 80-83).<br>Acknowledgments --- p.i<br>Bibliography --- p.ii<br>Contents --- p.iii<br>Abstract --- p.iv<br>Abbreviations --- p.v<br>Chapter I --- Introduction<br>Chapter I-1 --- General Background of Pseudo-sugar --- p.1<br>Chapter I-2 --- Monocarba-sugar --- p.2<br>Chapter I-3 --- Dicarba-sugar --- p.4<br>Chapter I-4 --- Isolation of Valiolamine and Its Related Compounds --- p.6<br>Chapter I-5 --- Previous Syntheses of Valiolamine --- p.8<br>Chapter II --- Result
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Lu, Shu-Wei, та 呂書瑋. "Studies on the Preparation of Water-soluble Low-molecular-weight Chitosan Derivatives and Their Free Radical Scavenging and α-glucosidase Inhibitory Activities". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/d8cvfw.

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碩士<br>靜宜大學<br>食品營養學系<br>103<br>Chitosan is a non-toxic, biocompatible and biodegradable natural macromolecule, and shown to be a valuable biopolymer because of its widespread applications in biomedical, food and chemical industries. However, chitosan has several drawbacks to be utilized in biological applications, including poor solubility under physiological conditions and high viscosity. Apparently it is important to prepare water-soluble chitosans and explore their biological activities. Therefor, in this study, three kinds of water-soluble low-molecular-weight chitosan (LMWC) derivatives w
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"Measurement of the trapping rate constants and product studies of quinone derivative inhibitors with alpha-phenethyl radicals." Thesis, 2009. http://hdl.handle.net/1911/61920.

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Polymerization of olefins such as styrene, one of many industrially important monomers, is a troublesome problem during storage, transportation and processing. The problem is attenuated by addition of polymerization inhibitors such as quinone derivatives. Despite the importance of quinone type inhibitors, their chemistry is poorly understood. The goal of this research is to better understand the reaction mechanism by measuring trapping rates and product studies of quinone type inhibitors with alpha-phenethyl radicals. cis Azo-alpha-phenylethane was used as a new simple, unimolecular, low tempe
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Books on the topic "Derivatives of alpha-glucosidase inhibitors"

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Bottorff, Michael B., William E. Evans, Ingrid Hillebrand, et al. Drug Concentration Monitoring Microbial Alpha-Glucosidase Inhibitors Plasminogen Activators. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73461-8.

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International, Symposium on Acarbose (3rd 1991 Munich Germany). New aspects in diabetes: Treatment strategies with alpha-glucosidase inhibitors : Third International Symposium on Acarbose. Walter de Gruyter, 1992.

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Alpha-Glucosidase Inhibitors. Elsevier, 2020. http://dx.doi.org/10.1016/c2017-0-02034-7.

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Evans, William E., Michael B. Bottorff, Lutz Müller, Ingrid Hillebrand, and Bodo Junge. Drug Concentration Monitoring Microbial Alpha-Glucosidase Inhibitors Plasminogen Activators. Springer London, Limited, 2012.

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Drug Concentration Monitoring Microbial Alpha-Glucosidase Inhibitors Plasminogen Activators. Akademie-Verlag, 1988.

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Bottorff, Michael B. Drug Concentration Monitoring Microbial Alpha-Glucosidase Inhibitors Plasminogen Activators. Island Press, 1988.

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Evans, William E., Michael B. Bottorff, Lutz Müller, Ingrid Hillebrand, and Bodo Junge. Drug Concentration Monitoring Microbial Alpha-Glucosidase Inhibitors Plasminogen Activators. Springer London, Limited, 2011.

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Ghani, Usman. Alpha-Glucosidase Inhibitors: Promising Candicates for Anti-Diabetic Drug Discovery. Elsevier, 2019.

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Ghani, Usman. Alpha-Glucosidase Inhibitors: Clinically Promising Candidates for Anti-Diabetic Drug Discovery. Elsevier, 2019.

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Lefebvre, P. J. New Aspects in Diabetes: Treatment Strategies With Alpha-Glucosidase Inhibitors : Third International Symposium on Acarbose. Walter De Gruyter Inc, 1992.

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Book chapters on the topic "Derivatives of alpha-glucosidase inhibitors"

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Wang, Kevin K. W., Avigail Posner, Kadee J. Raser, et al. "Alpha-Mercaptoacrylic Acid Derivatives as Novel Selective Calpain Inhibitors." In Intracellular Protein Catabolism. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0335-0_11.

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Häusler, Herwig, Karen Rupitz, Arnold E. Stütz, and Stephen G. Withers. "N-Alkylated Derivatives of 1,5-Dideoxy-1,5-iminoxylitol as β-Xylosidase and β-Glucosidase Inhibitors." In Timely Research Perspectives in Carbohydrate Chemistry. Springer Vienna, 2002. http://dx.doi.org/10.1007/978-3-7091-6130-2_14.

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Hanefeld, Markolf, and Frank Schaper. "The Role of Alpha-Glucosidase Inhibitors (Acarbose)." In Pharmacotherapy of Diabetes: New Developments. Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-69737-6_13.

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Ghani, Usman. "Azoles and related derivatives." In Alpha-Glucosidase Inhibitors. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-08-102779-0.00005-8.

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"Alpha-glucosidase inhibitors." In Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Elsevier, 2006. http://dx.doi.org/10.1016/b0-44-451005-2/00980-3.

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"Alpha-glucosidase inhibitors." In Meyler's Side Effects of Drugs. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-444-53717-1.00256-0.

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Hanefeld, Markolf. "Alpha-Glucosidase Inhibitors." In Type 2 Diabetes. CRC Press, 2007. http://dx.doi.org/10.3109/9780849379581-11.

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Kumthekar, Ajit. "Alpha Glucosidase Inhibitors." In Practical Management of Diabetes. Jaypee Brothers Medical Publishers (P) Ltd., 2010. http://dx.doi.org/10.5005/jp/books/11384_12.

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Kalra, Sanjay, and Jaikrit Bhutani. "Alpha-glucosidase Inhibitors." In Diabetology: Type 2 Diabetes Mellitus. Jaypee Brothers Medical Publishers (P) Ltd., 2014. http://dx.doi.org/10.5005/jp/books/12165_5.

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Bourdon, Allen K., Greg Villareal, George Perry, and Clyde F. Phelix. "Alzheimer's and Parkinson's Disease Novel Therapeutic Target." In Research Anthology on Diagnosing and Treating Neurocognitive Disorders. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-3441-0.ch021.

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Thiazolidinedione (TZD) drugs (Takeda Pharmaceuticals and Metabolic Solutions Development Company) targeting inhibition of the mitochondrial pyruvate carrier (MPC) are currently being tested in clinical trials to prevent progression into mild cognitive impairment of Alzheimer's disease (AD) or in the pipeline to prevent neurodegeneration in Parkinson's disease (PD). These have Ki values in the µM range. This study was focused on identifying candidate drug precursors of the natural cinnamic acid products that might have good bioavailability in the nM ranges forming covalent thiol bonds with tar
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Conference papers on the topic "Derivatives of alpha-glucosidase inhibitors"

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Hubbard, Arthur T., and James H. White. "Surface Spectroscopy: LEED, EELS and AES." In CORROSION 1991. NACE International, 1991. https://doi.org/10.5006/c1991-91264.

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Abstract Applications of low energy electron diffraction (LEED), Auger electron spectroscopy (AES), and electron energy loss spectroscopy (EELS) in the study of corrosion processes and corrosion inhibitor films are described. Studies in our laboratories of surface phemomena related to the depassivation, electrodissolution and corrosion of Fe-Ni-Cr alloys and the formation of polymer films on well- defined electrode surfaces will be presented to illustrate techniques and applications. For example, exposure of clean Fe-Cr-Ni(111) and Fe-Cr-Ni(111) to aqueous electrolytes forms an amorphous, hydr
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Diéguez-Santana, Karel, Oscar Rivera-Borroto, Amilkar Puris Caceres, and Gerardo Casañola-Martin. "A Simple Method to Classification α-Amylase and α-Glucosidase Inhibitors Using LDA and Decision Trees." In MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd edition. MDPI, 2017. http://dx.doi.org/10.3390/mol2net-03-04611.

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Reports on the topic "Derivatives of alpha-glucosidase inhibitors"

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Yibchok-anun, Sirintorn, and Nattaya Ngamrojanavanich. Structure-activity relationships of trans-cinnamic acid derivatives on inhibitions of alpha-glucosidase. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.86.

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Trans-Cinnamic acid and its derivatives were investigated for the a-glucosidase inhibitiory activity. 4-methoxy-trans-cinnamic acid and 4-methoxy-trans-cinnamic acid ethyl ester showed the highest potent inhibitory activity among those of trans-cinnamic acid derivatives. The presence of substituents at 4-position in trans-cinnamic acid derivatives. The presence of substituents at 4-position in trans-cinnamic acid altered the a-glucosidase inhibitory activity. Increasing of bulkiness and the chain length of 4-alkoxy substituents as well as the increasing of the electron withdrawing group have b
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Yibchok-anun, Sirinthorn, Wijit Banlunara, and Sirichai Adisakwattana. Antidiabetic effects, mechanisms of of p-methoxy-trans-cinnamic acid. Faculty of Veterinary Science, Chulalongkorn University, 2008. https://doi.org/10.58837/chula.res.2008.81.

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p-Methoxycinnamic acid (p-MCA) is a cinnamic acid derivative that shows various pharmacologic actions such as neuroprotective and hepatoprotective activities. To examine the insulinotropic activity of p-MCA, the perfused rat pancreas and a pancreatic β-cell line, INS-1 were used in the studies. P-MCA increased insulin secretion from the perfused rat pancreas and INS-1 cells in a concentration-dependent manner. In addition, p-MCA increased intracellular Ca²⁺ concentration ([Ca²⁺]i) in INS-1 cells. The p-MCA-induced insulin secretion and rise in [Ca²⁺]i were markedly inhibited in the absence of
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