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Relevant bibliographies by topics / Derivatives of coumarin

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Academic literature on the topic 'Derivatives of coumarin'

Author: Grafiati

Published: 24 April 2022

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Dissertations / Theses on the topic "Derivatives of coumarin"

1

Repsold, Benjamin Petrus. "Inhibition of monoamine oxidase B by substituted coumarin derivatives / Bennie Repsold." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4177.

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Interest in the selective inhibition of monoamine oxidase B (MAO-B) has increased in the last years due to their therapeutic potential in age related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Reversibly inhibiting MAO-B reduces the oxidative deamination of dopamine, increases dopamine levels and, consequently, reduces the production of reactive oxygen species (ROS) which may be the therapeutic intervention that positively affect the tempo and progression of neurodegenerative diseases. Coumarin analogues exhibit a broad spectrum of pharmacological activity,

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2

Musa, Musiliyu Ayodele. "Applications of the Baylis-Hillman reaction in the synthesis of coumarin derivatives." Thesis, Rhodes University, 2003. http://eprints.ru.ac.za/2319/1/MUSA-PhD-TR03-74.pdf.

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The reaction of specially prepared salicylaldehyde benzyl ethers with the activated alkenes, methyl acrylate or acrylonitrile, in the presence of the catalyst, DABCO, has afforded Baylis-Hillman products, which have been subjected to conjugate addition with either piperidine or benzylamine. Hydrogenolysis of these conjugate addition products in the presence of a palladium-on-carbon catalyst has been shown to afford the corresponding 3-substituted coumarins, while treatment of O-benzylated Baylis-Hillman adducts with HCl or HI afforded the corresponding 3-(halomethyl)coumarins directly, in up

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3

Rose, Nathan Rolf. "Synthesis of novel coumarin derivatives as potential inhibitors of HIV-1 protease." Thesis, Rhodes University, 2007. http://hdl.handle.net/10962/d1007220.

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This research has focused on the development of novel coumann derivatives containing peptide-like side chains as potential HIV-1 protease inhibitors. The reaction of various salicylaldehyde derivatives with tert-butyl acrylate In the presence of 1,4- diazabicyclo[2.2.2]octane (DABCO) has afforded a series of Baylis-Hillman adducts in moderate yield. Cyclisation of the adducts in the presence of HCI afforded the corresponding 3-(chloromethyl)coumarin derivatives, which have been reacted with various amine hydrochlorides in the presence of Proton Sponge® to afford a series of novel 3- (aminometh

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4

Concannon, Shauna. "A study of the isolation, synthesis, structural elucidation and biological properties of coumarin derivatives." Thesis, University of Ulster, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274067.

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5

Neubauer, Stefan. "Photocycloadditionen von 2-donorsubstituierten Propennitrilen an Cumarinderivate - Photocycloadditions of 2-donor substituted propenenitriles to coumarin derivatives." Gerhard-Mercator-Universitaet Duisburg, 2001. http://www.ub.uni-duisburg.de/ETD-db/theses/available/duett-05222001-100519/.

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Reactions of photoexcited coumarins and their thia analogues with captodative alkenes have been investigated, with special emphasis on the nature of the excited states and the specific influence of the substrates on regio- and stereoselectivity of the observed [2+2]-photocycloadditions. Aside of two coumarin thiones all coumarins investigated regioselectively add captodative alkenes at the pyranone moeity giving rise to head-to-tail [2+2]-photocycloadducts with donor-endo adducts as prevailing isomers. The observed regio- and stereoselectivities can be best explained if a 1,4-biradical is assu

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6

Pemberton, Barry Charles. "From Nanocontainer to Nanocatalyst: Mechanistic Studies of [2+2] Photodimerization of Coumarin Derivatives within Cucubit[8]URIL." Diss., North Dakota State University, 2013. https://hdl.handle.net/10365/26752.

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Controlling photoreactions remains a formidable challenge to chemists who have developed several approaches with varying degrees of success to achieve high reactivity/selectivity. Following nature's footprints, chemists have explored the use of confined media for controlling photoreactions. This thesis explores catalytic aspects of a water-soluble supramolecule known as a cucurbituril. Cucurbituril is a macrocyclic oligomer with a large enough cavity to sequester two guest molecules of appropriate size. The guest molecules explored in this thesis is coumarins. The model investigation involves

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7

Rashamuse, Thompho Jason. "Studies towards the synthesis of novel, coumarin-based HIV-1 protease inhibitors." Thesis, Rhodes University, 2008. http://eprints.ru.ac.za/1332/.

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8

Foka, Germaine Boulenoue. "Synthesis and evaluation of novel coumarin-donepezil derivatives as dual acting monoamine oxidase B and cholinesterase in Alzheimer's disease." University of the Western Cape, 2016. http://hdl.handle.net/11394/5549.

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Magister Pharmaceuticae - MPharm<br>Alzheimer's disease is a progressive neurodegenerative disease characterised by low acetylcholine (ACh) levels in the hippocampus and cortex of the brain, causing symptoms like progressive memory loss, decline in language skills and other cognitive impairments to occur. The hallmarks of AD include the presence of extracellular insoluble amyloid beta plaques, intracellular neurofibrillary tangles, and the decrease in ACh concentration. The pathophysiology of AD is not well understood, however, acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and mon

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9

Aydin, Engin Aytac [Verfasser]. "Diels-Alder Reactions of Phencyclone and Coumarin Derivatives and Click Chemistry of Novel BODIPY Dyes for Fluorescence Detection / Engin Aytac Aydin." Wuppertal : Universitätsbibliothek Wuppertal, 2013. http://d-nb.info/103802739X/34.

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10

Mzezewa, Sheunopa C. "Synthesis and evaluation of 7-substituted 3-propargylamine coumarin derivatives as multifunctional monoamine oxidase and cholinesterase inhibitors for Alzheimer’s Disease treatme." University of Western Cape, 2020. http://hdl.handle.net/11394/7399.

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>Magister Scientiae - MSc<br>Alzheimer’s Disease (AD) is a neurodegenerative disease which results from the irreversible loss of neurons in the brain. The disease is characterized by progressive cognitive impairment with recurrent short-term memory loss. AD is the leading cause of dementia and 4th leading cause of death in the elderly. Success in the treatment of AD has been limited, with drugs only treating it at a symptomatic level due to its pathology being complex and poorly understood. However, it is known that the cholinesterase and MAO-B enzymes play an important role in the disease thr

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