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Dissertations / Theses on the topic 'Derivatives of coumarin'

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Published: 24 April 2022

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1

Repsold, Benjamin Petrus. "Inhibition of monoamine oxidase B by substituted coumarin derivatives / Bennie Repsold." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4177.

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Interest in the selective inhibition of monoamine oxidase B (MAO-B) has increased in the last years due to their therapeutic potential in age related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Reversibly inhibiting MAO-B reduces the oxidative deamination of dopamine, increases dopamine levels and, consequently, reduces the production of reactive oxygen species (ROS) which may be the therapeutic intervention that positively affect the tempo and progression of neurodegenerative diseases. Coumarin analogues exhibit a broad spectrum of pharmacological activity,
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2

Musa, Musiliyu Ayodele. "Applications of the Baylis-Hillman reaction in the synthesis of coumarin derivatives." Thesis, Rhodes University, 2003. http://eprints.ru.ac.za/2319/1/MUSA-PhD-TR03-74.pdf.

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The reaction of specially prepared salicylaldehyde benzyl ethers with the activated alkenes, methyl acrylate or acrylonitrile, in the presence of the catalyst, DABCO, has afforded Baylis-Hillman products, which have been subjected to conjugate addition with either piperidine or benzylamine. Hydrogenolysis of these conjugate addition products in the presence of a palladium-on-carbon catalyst has been shown to afford the corresponding 3-substituted coumarins, while treatment of O-benzylated Baylis-Hillman adducts with HCl or HI afforded the corresponding 3-(halomethyl)coumarins directly, in up
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3

Rose, Nathan Rolf. "Synthesis of novel coumarin derivatives as potential inhibitors of HIV-1 protease." Thesis, Rhodes University, 2007. http://hdl.handle.net/10962/d1007220.

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This research has focused on the development of novel coumann derivatives containing peptide-like side chains as potential HIV-1 protease inhibitors. The reaction of various salicylaldehyde derivatives with tert-butyl acrylate In the presence of 1,4- diazabicyclo[2.2.2]octane (DABCO) has afforded a series of Baylis-Hillman adducts in moderate yield. Cyclisation of the adducts in the presence of HCI afforded the corresponding 3-(chloromethyl)coumarin derivatives, which have been reacted with various amine hydrochlorides in the presence of Proton Sponge® to afford a series of novel 3- (aminometh
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4

Concannon, Shauna. "A study of the isolation, synthesis, structural elucidation and biological properties of coumarin derivatives." Thesis, University of Ulster, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274067.

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5

Neubauer, Stefan. "Photocycloadditionen von 2-donorsubstituierten Propennitrilen an Cumarinderivate - Photocycloadditions of 2-donor substituted propenenitriles to coumarin derivatives." Gerhard-Mercator-Universitaet Duisburg, 2001. http://www.ub.uni-duisburg.de/ETD-db/theses/available/duett-05222001-100519/.

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Reactions of photoexcited coumarins and their thia analogues with captodative alkenes have been investigated, with special emphasis on the nature of the excited states and the specific influence of the substrates on regio- and stereoselectivity of the observed [2+2]-photocycloadditions. Aside of two coumarin thiones all coumarins investigated regioselectively add captodative alkenes at the pyranone moeity giving rise to head-to-tail [2+2]-photocycloadducts with donor-endo adducts as prevailing isomers. The observed regio- and stereoselectivities can be best explained if a 1,4-biradical is assu
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6

Pemberton, Barry Charles. "From Nanocontainer to Nanocatalyst: Mechanistic Studies of [2+2] Photodimerization of Coumarin Derivatives within Cucubit[8]URIL." Diss., North Dakota State University, 2013. https://hdl.handle.net/10365/26752.

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Controlling photoreactions remains a formidable challenge to chemists who have developed several approaches with varying degrees of success to achieve high reactivity/selectivity. Following nature's footprints, chemists have explored the use of confined media for controlling photoreactions. This thesis explores catalytic aspects of a water-soluble supramolecule known as a cucurbituril. Cucurbituril is a macrocyclic oligomer with a large enough cavity to sequester two guest molecules of appropriate size. The guest molecules explored in this thesis is coumarins. The model investigation involves
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7

Rashamuse, Thompho Jason. "Studies towards the synthesis of novel, coumarin-based HIV-1 protease inhibitors." Thesis, Rhodes University, 2008. http://eprints.ru.ac.za/1332/.

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8

Foka, Germaine Boulenoue. "Synthesis and evaluation of novel coumarin-donepezil derivatives as dual acting monoamine oxidase B and cholinesterase in Alzheimer's disease." University of the Western Cape, 2016. http://hdl.handle.net/11394/5549.

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Magister Pharmaceuticae - MPharm<br>Alzheimer's disease is a progressive neurodegenerative disease characterised by low acetylcholine (ACh) levels in the hippocampus and cortex of the brain, causing symptoms like progressive memory loss, decline in language skills and other cognitive impairments to occur. The hallmarks of AD include the presence of extracellular insoluble amyloid beta plaques, intracellular neurofibrillary tangles, and the decrease in ACh concentration. The pathophysiology of AD is not well understood, however, acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and mon
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9

Aydin, Engin Aytac [Verfasser]. "Diels-Alder Reactions of Phencyclone and Coumarin Derivatives and Click Chemistry of Novel BODIPY Dyes for Fluorescence Detection / Engin Aytac Aydin." Wuppertal : Universitätsbibliothek Wuppertal, 2013. http://d-nb.info/103802739X/34.

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10

Mzezewa, Sheunopa C. "Synthesis and evaluation of 7-substituted 3-propargylamine coumarin derivatives as multifunctional monoamine oxidase and cholinesterase inhibitors for Alzheimer’s Disease treatme." University of Western Cape, 2020. http://hdl.handle.net/11394/7399.

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>Magister Scientiae - MSc<br>Alzheimer’s Disease (AD) is a neurodegenerative disease which results from the irreversible loss of neurons in the brain. The disease is characterized by progressive cognitive impairment with recurrent short-term memory loss. AD is the leading cause of dementia and 4th leading cause of death in the elderly. Success in the treatment of AD has been limited, with drugs only treating it at a symptomatic level due to its pathology being complex and poorly understood. However, it is known that the cholinesterase and MAO-B enzymes play an important role in the disease thr
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11

Muschket, Matthias Verfasser], Henner [Akademischer Betreuer] [Hollert, and Werner [Akademischer Betreuer] Brack. "Effect-directed identification and fate analysis of potent antiandrogenic coumarin derivatives in a central European river / Matthias Muschket ; Henner Hollert, Werner Brack." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/1180731344/34.

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12

Muschket, Matthias [Verfasser], Henner [Akademischer Betreuer] Hollert, and Werner [Akademischer Betreuer] Brack. "Effect-directed identification and fate analysis of potent antiandrogenic coumarin derivatives in a central European river / Matthias Muschket ; Henner Hollert, Werner Brack." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/1180731344/34.

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13

Xu, Dawen [Verfasser], Fritz E. [Akademischer Betreuer] Kühn, Fritz E. [Gutachter] Kühn та Lukas [Gutachter] Hintermann. "Intramolecular α-alkylation and α-alkenylation of coumarin and quinolinone derivatives / Dawen Xu ; Gutachter: Fritz E. Kühn, Lukas Hintermann ; Betreuer: Fritz E. Kühn". München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1192911644/34.

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14

Sabbagh, Liezel Veronica. "Chemical studies of chromone derivatives." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1006899.

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This study has focussed on several aspects of chromone chemistry, viz., (i) the influence of remote substituents on the basicity of 2-(N,N-dimethylamino)chromones, (ii) MoritaBaylis-Hillman reactions of substituted chromone-3-carbaldehydes and (iii) an investigation into the application of chromone chemistry in the total synthesis of the marine natural product, Rietone A. Selected 2-(N,N-dimethylamino )chromones were prepared using two different methods; firstly, via cyclisation of salicylate-derived N,N-dimethyl-3;.(2-hydroxyphenyl)-3- oxopropanamide precursors and, secondly, via 2-hydroxyace
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15

Robinson, Ross Stuart. "Baylis-Hillman derived benzopyrans and related systems : a synthetic and mechanistic study." Thesis, Rhodes University, 1998. http://hdl.handle.net/10962/d1007193.

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The Baylis-Hillman reaction between substituted salicylaldehydes and various acrylate species has been shown to afford complex reaction mixtures, careful chromatography of which has led to the isolation of an extensive range of novel compounds. One- and two-dimensional NMR spectroscopic, mass spectrometric and X-ray crystallographic analysis of these compounds have permitted identification of no less than eight general classes of chromene and coumarin derivatives. The formation of the various product types is attributed to cascades of successive reactions stemming, in each case, from a Baylis-
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16

Ramaite, Ipfani David Isaiah. "Synthetic and physical organic studies of chromone derivatives." Thesis, Rhodes University, 1997. http://hdl.handle.net/10962/d1005045.

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A range of chromone-2-carboxylic acids has been prepared by condensing suitably substituted 2-hydroxyacetophenones with diethyl oxalate. pK₂ Studies of these acids revealed that 6- or 7-methoxy substituents decreased acidity while the 6-nitro group enhanced acidity; the strongest acid was the 3-chloro derivative, the increase in acidity being attributed to steric inhibition of acid-weakening delocalisation between the carboxyl group and the chromone system. Various chromone-2-carboxamides, derived from acid chloride precursors, were converted to polysubstituted acrylamides by nucleophilic ring
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17

Rodriguez, Dominguez Juan Carlos Kirsch Gilbert Prieto Sylvia. "Nouvelles synthèses de dérivés hetérocycliques pour applications biologiques (Céphalosporines, Coumarines et Indoles) = New synthesis of heterocyclic derivatives for biological applications (Cephalosporins, Coumarins and Indoles) /." [S.l.] : [s.n.], 2006. ftp://ftp.scd.univ-metz.fr/pub/Theses/2006/Rodriguez%20Dominguez.Juan%20Carlos.SMZ0618.pdf.

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18

Rodriguez, Dominguez Juan Carlos. "Nouvelles synthèses de dérivés hetérocycliques pour applications biologiques : (Céphalosporines, Coumarines et Indoles) = New synthesis of heterocyclic derivatives for biological applications (Cephalosporins, Coumarins and Indoles)." Metz, 2006. http://docnum.univ-lorraine.fr/public/UPV-M/Theses/2006/Rodriguez_Dominguez_Juan_Carlos_SMZ0618.pdf.

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Les céphalosporines de synthèse, les dérivés de coumarines et indoles sont des composés très intéressant dans le domaine de la biochimie. Les premières sont utilisées habituellement dans le système de santé mondiale contre les infections bactériennes ; les secondes et les dernières, sont présentes dans les sciences de la nature et de la vie avec des larges gammes d'activités et des usages biologiques. Due à leurs importantes applications, il apparait nécessaire d'avoir des méthodes efficaces pour synthétiser ces produits. Des temps de réactions plus courts, de bons rendements, un travail fait
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19

Ramaite, Ipfani David Isaiah. "Chemical and spectroscopic studies of chromone derivatives." Thesis, Rhodes University, 1993. http://hdl.handle.net/10962/d1006888.

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A number of biologically active chromones occur in plants (eg. Khellin) and research in this field has eventually led to the discovery of chromoglycic acid, which is widely used as a sodium salt in asthma therapy. Since biological activity may be related to acidity, a range of chromone-2-carboxylic acids have been prepared via Claisen acylation of substituted o- hydroxyacetophenones and their acid dissociation constants determined potentiometrically to explore substituent effects. From this study it has been found that introduction of certain groups does have a marked effect on acidity. A vari
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20

Fersi, Hannan. "Time-resolved spectroscopic studies of Psoralens, Khellin, Visnagin and Lumichrome and derivatives." The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1141847576.

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21

Raffa, Guillaume. "Hétérocyclisations électrophiles et pallado-catalysées d’α-alcynyl β-alcoxyénones (et systèmes apparentés) : nouvelles voies d’accès à des dérivés furaniques tétrasubstitués". Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10236.

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22

Hu, Sheng-Qi, and 胡勝琪. "Coumarin Carbohydrazide Derivatives as Chemosensors." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/hmsm7g.

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碩士<br>靜宜大學<br>應用化學系<br>107<br>In this thesis, a series of coumarin carbohydrazine derivatives were prepared via different substituted aromatic aldehydes to evaluate the effects of sensing anions and cations. Due to the spatial configuration of the aromatic ring and nitrogen of the coumarin carbohydrazine derivatives, there exist the possibility to chelate the divalent copper ion. The results demonstrated that the treatment of copper ion with compounds 4d and 4i resulted in a color change from colorless to yellow. As can be seen in the absorption spectra, a new absorption peak appears at 410 nm
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23

Kasumbwe, Kabange. "Biological activities of synthetic coumarin derivatives." Thesis, 2016. http://hdl.handle.net/10321/1733.

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Submitted in partial fulfillment for the Degree of Master of Applied Sciences in Biotechnology, Durban University of Technology, Durban, South Africa, 2016.<br>Coumarins are naturally occurring α-benzopyrone derivatives known for their pharmacological properties such as anticoagulant, antimicrobial, anticancer, antioxidant, anti-inflammatory and antiviral properties. The pharmacological, biochemical, and curative applications of coumarins depend on the substitution around the coumarin core structure. In the present study, seven halogenated coumarins CMRN1 - CMRN7 were synthesized and evaluated
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24

Huang, Wan-Pei, and 黃婉珮. "Applications of Coumarin Derivatives to Metal Sensors." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/33185409232350174964.

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蘇長孝. "Synthesis and Biological Evaluation of Coumarin Derivatives." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/86203434887042864258.

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碩士<br>國防醫學院<br>藥學研究所<br>92<br>It has been reported that coumarin derivatives showed many medical properties, such as anticoagulant, allergic and antimicrobial. Recently, coumarin derivatives has further been applied to the treatment of the AIDS. NSC158393, a coumarin tetramer, has shown potent inhibitory activity (IC50 = 1.5 µM) against HIV-1 integrase. Based on the structural features of the lead compound, we start to design and synthesize 42 compounds with similar structural features. Synthesis to the target compounds was performed starting from mono- or di-hydroxybenzoic acid with 4-hydroxy
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Zheng, Dong-Yang, and 鄭東陽. "Synthesis of Coumarin Derivatives as Potential UV Absorbers." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/01576818039766286330.

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碩士<br>中華科技大學<br>健康科技研究所<br>101<br>In the past decades, the amounts of UV radiation reaching to the surface of the earth has been increasing due to the collapsed ozone layer. When people are overexposed to the circumstances of the UV sunlight, it may cause a number of skin damage such as spots, wrinkle, hyperpigmentation and even skin cancer. Chemical sunscreens, absorbing and converting high-intensity UV rays into longer lower-energy unharmful wavelengths have proven to be quite effective for the prevention of the erythema reaction of human skin. However, in order to get the high effectiveness
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Chang, Chao-Che, and 張肇哲. "Synthesis of Coumarin Derivatives for Metal Ions Sensing." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/19545765182091694512.

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碩士<br>國立臺灣大學<br>化學研究所<br>93<br>The main objective of this thesis is to design and synthesize fluorescent chemosensors for detection of metal ions. Coumarin fluorophores were chosen to serve as signal transducer. Various recognition units were coupled with the signal transducer units in order to investigate how these recognition units influence metal ion selectivity. Accordingly, fluorescent chemosensor 1-9 were prepared. Both fluorosensor 1 and 2 consist of polyethylene glycol as recognition unit. The preorganized recognition unit, diaza-18-crown-6, was employed in the case of fluorosensors 3
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CHANG, FANG-CHI, and 張芳齊. "Synthesis of New Coumarin Derivatives for Metal Ion." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/36334925674936309779.

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碩士<br>明志科技大學<br>化學工程系碩士班<br>105<br>In this study, coumarin derivative (C6H-Imine) had been successfully synthesized by Vilsmeier reaction, Knoevenagel condensation, hydrolysis and condensation of amine and aldehydes. The structures of these coumarin dyes (C6H-Ethyl ester, C6H, C6H-Aldehyde and C6H-Imine) were characterized by 1H-NMR, FTIR and MASS spectra. The photophysical properties of the C6H-Imine were studied by absorption and steady-state fluorescence spectroscopy in acetonitrile, and compared with the C6H-Imine(methyl). The photophysical results showed that the C6H-Imine without a methy
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Liu, Yan-Rong, and 劉晏榮. "A Novel Fluorescent Sensor Based on Coumarin Derivatives." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/16655397075613830622.

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碩士<br>明志科技大學<br>化學工程研究所<br>101<br>In this study, coumarin 6H derivatives (C6H-NO2, C6H-NH2 and compound A) had been successfully synthesized by Vilsmeier reaction, Knoevenagel condensation, reduction and condensation of primary amine and aldehyde. The structures of these coumarin dyes were characterized by 1H-NMR, FTIR and MASS spectra. The photophysical properties of these dyes were studied by absorption and steady-state fluorescence spectroscopy in dichloromethane and acetonitrile/water (9:1). The compound A was designed and used as an optical chemosensor for metal ion and could recognize Z
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Chou, Yu-Shiang, and 周裕翔. "Study on the antioxidant activity of coumarin derivatives." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/73140093187127013036.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>98<br>In our previous study, we demonstrated that baicalein induced superoxide and hydroxyl radical formation in B16F10 mouse melanoma cell line. We also found the reactive oxygen species (ROS) production is related to the arachidonic acid (AA) metabolism way. Simultaneously baicalein caused reduction of cellular viability and cell apoptosis. In this study, we use electron spin resonance (ESR) to analyze different systems, investigating the antioxidant activity of coumarin derivatives. System I using DPPH and found that coumarin derivatives all have the antioxidant a
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Lin, Yu Chung, and 林佑忠. "Synthesis of Coumarin Derivatives and Their Photophysical Property Studies." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/97357796346039188852.

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碩士<br>國立臺灣大學<br>化學研究所<br>90<br>Most of coumarin derivatives, like coumarin 1 and coumarin 6, have highly fluorescent quantum efficiency in solution, but at solid phase their fluorescent quantum efficiency rapidly decreases. The main reason of causing the decrease of quantum efficiency can be attributed to the phenomenon of aggregation. The objectives of this research is to design and synthesize coumarin derivatives with high fluorescent yield not only in solution also at solid state. The diphenyl amino groups are introduced in the place of the diethyl amino group at 7-position of coumarin. Th
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PENG, YU-TING, and 彭郁婷. "Multicomponent Synthesis of Pyrrolizidine and Azepine/Coumarin-Fused Derivatives." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/77509669272920214476.

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碩士<br>東海大學<br>化學系<br>105<br>In this thesis, we report the design, synthesis, and characterization of pyrrolizidine and azepine/coumarin-fused compounds via multicomponent reactions and subsequent evaluation of their potential antibacterial activities. In the first part, microwave-assisted three-component reactions of L-proline, benzaldehyde and 1,3-indandione obtained the pyrrolizidine derivatives. In the second part, the azepine/coumarin-fused seven-membered heterocyclic derivatives were prepared by condensation of 3-amino-4-hydroxycoumarin with acetophenone in a pseudo three-component reacti
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Kang, Shiuan-tsang, and 康玄蒼. "Iridium Complexes and Coumarin Derivatives for Polymeric Light Emitting Diodes." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/45649075431946601035.

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碩士<br>國立中正大學<br>化學所<br>95<br>We have synthesized a series of fluorene based copolymer with coumarin derivatives as dopant. The photophysical, electrochemical and electroluminescene properties of these copolymers has been systematically investigated. The glass transition temperatures of these copolymers are very high, since the rigidity of polyfluorene backbone. Pure blue electroluminescene was achieved from these copolymers as an emitting layer in light emitting device. A maximum brightness of 517 cd/m2 and a maximum external quantum efficiency of 0.83 % was obtained in the configuration ITO/P
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Chou, Wei-Cheng, and 周韋丞. "Synthesis of New Adenosine–Coumarin Phosphate Derivatives Against Flaviviridae Viruses." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/h56du5.

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Li, Xhian-Bin, and 李賢斌. "Synthesis of Coumarin Derivatives and Discussions of Their Fluorescent Properties." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/82sv69.

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碩士<br>國立臺北科技大學<br>有機高分子研究所<br>93<br>In general, derivatives of coumarin have superior fluorescent properties and good quantum yield, thus they were be taken as luminescent materials on luminescent layer in organic light emitting diodes which emit blue and green light. Three series of coumarin dyes were synthesized from raw materials. Among them, dyes of series Ⅱ are new compounds. The relationship between their optical properties with the structure of dyes were discussed. The fluorescence wavelengths of Dye ⅠC、ⅡC and ⅢC are in neutral red light range. PLED and OLED devices were prepared by Dy
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Lin, Yu-Ching, and 林育靖. "Preparation and Bio-activity Studies of 7-Arylethtynyl-Coumarin Derivatives." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/24593740104259121020.

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碩士<br>國立中興大學<br>化學系所<br>100<br>Coumarin derivatives are a calss of nature compounds presented in many plants and most of then possess antifungal, antibacterial, anti-tumour, and antibiotic activites etc. The coumarin moiety as chromophore of fluorescent indicator is a useful physical character in imaging technique in biological systems. Our recent attempts in the modification of 7-OTf-coumarine with alkynes by the method of Sonogashira reaction led to the formation of several coumarin derivatives with expected red-shift of wavelength in fluorescence. Applications of these compounds in the stud
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Wu, Tsung-Tse, and 吳宗澤. "Preparation and Spectroscopic Analysis of 3-(6’-Aminobenzothiazoyl)coumarin Derivatives." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/17074160873333292769.

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碩士<br>靜宜大學<br>應用化學系<br>99<br>The nature of coumarins, a class of the nature product, on emitting strong fluorescence with wide biological activities have drew the scientist’s attention. Nowadays, a series of coumarin derivatives has applied as orangic fluorescent dyes. A series of mono- and di-substituted 3-benzothiazolcoumarins have been prepared for investigating the influence of nature of substituents on the coumarin ring and benzothiazole ring on UV-Vis absorption and emission wavelength as well as fluorescence intensity. Our study focus on derivatizatioon of 3-(6’-nitrobenzothiazoyl)- cou
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CHANG, WEI HSIN, and 張維新. "Applications of Coumarin Derivatives in the Heavy Metal Ions Sensing." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/63510846199707419471.

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碩士<br>國立臺灣大學<br>化學研究所<br>91<br>The objective of this thesis is to design and synthesize fluosensors 4-9, which consist of coumarin-based signal-transducing units and various recognition units. Structure features v.s. heavy metal selectivity will be discussed in details. Fluorosensor 4, which has no defined recognition site, displayed small fluorescence changes in the presence of 15 metal ions examined, whereas fluorosensor 5 having 15-monoazacrown-5 ether incorporated at the meta-position of benzoyl moiety showed tight binding with Ca2+, Ba2+, Cd2+, Pb2+ and displayed fluorescence e
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Lin, Li, and 林立. "Synthesis and Biological Evaluation of Coumarin-3-Carboxamide Derivatives via Ring-Opening Reaction of Coumarin-3-Activated Aziridines." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/51699927764062756603.

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碩士<br>臺北醫學大學<br>藥學系<br>94<br>Coumarin is important structure of organic chemistry and belongs to the benzopyrones. Coumarins are widely distributed in plants and have a variety of bioactivities including anticoagulation, estrogenic, dermal photosensitizing, antimicrobial, antioxidation, vasodilation, antithelmintic, sedative and hypnotic, analgesic and hypothermic activities. Aziridine is a class of compound important both in chemical synthesis and in chemotherapy of cancer. Ring opening of 2-methyl-N-acylaziridine by various nucleophiles has been reported. Nucleophilic attack at the
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Li, Kuan-Ting, and 黎冠廷. "Synthesis of Coumarin-Based Heterocyclic Derivatives as Potential Multifunctional Molecular Switches." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/20998178428893972893.

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碩士<br>東海大學<br>化學系<br>100<br>In part one, a number of coumarin/phenanthridine-fused heterocycles were efficiently synthesized using base-mediated annulation of coumarin and N-alkylquinolinium iodide as a key step. The prepared compounds and their corresponding ring open forms exhibit lockable switching properties, that is, they are interchangeable via pH control and can also be further converted to their “pH-inert” forms by chemical oxidation and reduction. In part two, two new pyranocoumarins were synthesized and characterized via one-pot, microwave-assisted pseudo multicomponent condensation
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Hsiao, Chan-Ya, and 蕭晨雅. "Perparation of 6-Alkynyl-Coumarin Derivatives: Cytotoxicity and Optical-physical Studies." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/69892707241399660467.

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碩士<br>國立中興大學<br>化學系所<br>98<br>Many coumarin derivatives are biologically important molecules that possess antifungal, antibacterial, antimicrobial insecticidal, anti HIV and antibiotic activites. The coumarin moiety as chromophore of fluorescent ion indicators is a useful physical property for the bio-image technique in biological systems. It was expected that an extension of coumarin with conjugated multiple bonds might bring about the significant change in either red-shift of wavelength or intensity of the emission. Recently, several attempts in modification of 6-Br-coumarin with alkynes by
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Liao, Yuan-Cheng, and 廖元正. "Applications of Coumarin Derivatives to CD Exciton, OLED Materials and Chemosensors." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/19170741048585289118.

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Fernandes, Maria José G. "Fused polycyclic and coumarin derivatives as fluorescent phototriggers for neurotransmitter caging." Doctoral thesis, 2012. http://hdl.handle.net/1822/21483.

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Tese de doutoramento em Ciências (área de especialização em Química)<br>Photochemical release is an important strategy in the study of various processes in areas such as chemistry, biology, medicine and materials science since it allows the controlled release of molecules with biological, analytical and biomedical relevance. The use of photocleavable protecting groups in the control of the spatial and temporal evolution of species with biological activity has become relevant in the investigation of the mechanisms of signal transduction at the cellular level or in the photocontrolled drug
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Kao, Sheng-Han, and 高聖涵. "Preparation and Spectroscopic Analysis of 3-Propenenitrilyl(2-benzothiazoyl)coumarin Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/61983196167315832617.

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碩士<br>靜宜大學<br>應用化學系<br>103<br>The nature of coumarins, which is a class of the nature product, emitting strong fluorescence with wide biological activities, have drawn the scientists’ attention. Coumarin derivatives have applied as organic fluorescent dyes now days. A series of 3-benzothiazolcoumarins have been prepared for investigating the influence of nature of substituents on the coumarin ring and benzothiazole ring on UV-Vis absorption and emission wavelength as well as fluorescence intensity. We introduce a double bond at C3 of 7-diethylaminocoumarin to add cyano group and benzothia
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Lee, Yen-Te, and 李彥得. "Investigation of Asymmetric Organocatalytic Michael Additions of Ketones toward Coumarin Derivatives." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/13094296959043329092.

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碩士<br>國立臺灣師範大學<br>化學系<br>102<br>The dissertation is divided into two parts : investigation of asymmetric organocatalytic michael additions of ketones toward coumarin derivatives (part I), and preparation of Functional Benzothiophene and Furan via Intramolecular Wittig Reactions (part II). In the first part, we showed that asymmetric synthesis of optically active chroman-2-one derivatives can be achieved starting from ketones and diversely substituted 3-aroyl coumarins catalysed by readily available cinchona-alkaloid derived primary amines. A series of substituted chroman-2-one compounds were o
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Yang, Mei-Chun, and 楊玫春. "The application of coumarin derivatives in Wittig reactions and asymmetric organocatalysis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/85740457639620116435.

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碩士<br>國立臺灣師範大學<br>化學系<br>100<br>The dissertation is divided into two parts: preparation of new types of heterocycles bearing coumarin moieties via intramolecular Wittig reactions as key steps (part I) and development of organocatalytic Michael addition reactions of cyclohexanone or propionaldehyde towards the designed Michael acceptors with coumarin moieties (part II). In part I, three kinds of designed coumarin derivatives as Michael acceptors are proposed and successfully react with a wide variety of acid chlorides, tributylphosphine, and triethylamine via intramolecular Wittig reactions to
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Li, You-chang, and 黎祐誠. "Synthesis and Metal Recognition Behavior Studies of Coumarin Substituted Ferrocene Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/67439628190648748143.

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碩士<br>朝陽科技大學<br>應用化學系碩士班<br>102<br>This study use azine group to linked coumarin group and ferrocene unit, and we are also makes different modified on the ferrocene unit. Both compound S and S1were characterized by NMR, IR and Mass spectra to confirm the structure. Compound S shows obviously recognize behavior with mercury ions. In the UV-vis spectra, when Hg ions added in the solution of S, the absorption band will lead to a red shift, which is speculated the result of coordination of Hg ion with azine group and coumarin unit. In Job&apos;&apos;s plot experiments, the binding mode of compound
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Yu, Ting-Bin, and 游廷彬. "Development of Coumarin Derivatives in Fluorescent and Nanoparticle-based Sensing Materials." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/32292847963599449050.

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碩士<br>國立臺灣大學<br>化學研究所<br>92<br>In recently, the need for selective and sensitive sensors able to monitor in real-time and real-space is nowadays generally accepted. Because metal ions play a important role in our daily life. In our study, we synthesized a series of coumarin-derivatives for sensing heavy metal ions. We designed coumarin group as signal readout unit, and combined different positions and sizes of recognition sites: “crown-ether”. They displayed a highly specificity and fluorescence-enhancement to the hard metal ions: lead ion. In the titration experiment of NMR and IR spectroscop
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Yueh, Han, and 岳瀚. "Applications of Coumarin Derivatives in Fluorescent Sensors Base on PET Mechanism." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/50115672906072598955.

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碩士<br>國立臺灣大學<br>化學研究所<br>91<br>The objective of this thesis is to use coumarin derivatives as molecular scaffold to design fluorosensors for detecting metal ions and monosaccharides based on PET (Photoinduced Electron Transfer) sensory mechanism. Evidences are also shown to reveal the origin of the fluorescence changes of these sensors. Coumarin derivatives (1-8) containing various electron-withdrawing groups display different fluorescent intensity owing to the attenuation of PET mechanism by these substituents. Based on this concept, we designed fluorosensors, which can switch on o
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Wu, Ren-Tsung, and 吳仁琮. "Syntheses and Metal Ion-Sensing Properties of Novel Heterocycle-Substituted Coumarin Derivatives." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/92074591040230256899.

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碩士<br>國立交通大學<br>應用化學系所<br>96<br>Based on our design, 7-methoxycoumarin was chosen as the fluorophore, and heterocyclic building blocks, such as 1,4-triazole and di-2-picolylamino (DPA) groups, were ultilized as the ionophores for metal ions. These two units were jointed with methylene, acetyl, and amide bridges respectively to afford a series of novel coumarin-based fluoroionophores 13, 14, 15, and 17. The photophysical and metal ion-sensing properties of these products were examined in acetonitrile. The changes in fluorescence and ion selectivity of each product were found to be different f
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