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Journal articles on the topic 'Derivatives of hydantoin'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

López-López, Lluvia Itzel, Denisse de Loera, Ernesto Rivera-Avalos, and Aidé Sáenz-Galindo. "Green Synthesis of Hydantoins and Derivatives." Mini-Reviews in Organic Chemistry 17, no. 2 (2020): 176–84. http://dx.doi.org/10.2174/1570193x16666181206100225.

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The hydantoin moiety is found in several bioactive compounds with important pharmacological properties such as antimicrobial, antifungal, anti-androgens, anticancer and the historical action anticonvulsant. Because of these reasons, the synthesis of these compounds and their derivatives is important to review considering the philosophy of the green chemistry. In this review, we present the actual importance in the green synthesis of hydantoins and their derivatives using green methods, such as microwave and ultrasound irradiation, ionic liquids, solid-phase and solvent-free synthesis. Finally,

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2

Yu, Fang-Lei, Carl H. Schwalbe, and David J. Watkin. "Hydantoin and hydrogen-bonding patterns in hydantoin derivatives." Acta Crystallographica Section C Crystal Structure Communications 60, no. 10 (2004): o714—o717. http://dx.doi.org/10.1107/s0108270104017706.

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3

ASAKAWA, Takanobu, and Somei YARITA. "Noncyanide Silver Plating Solution Using Hydantoin and Hydantoin Derivatives." Journal of the Surface Finishing Society of Japan 50, no. 1 (1999): 68–71. http://dx.doi.org/10.4139/sfj.50.68.

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4

Hanessian, Stephen, Rui-Yang Yang, and Jean-Yves Sancéau. "Synthesis of 1-N-hydroxyhydantoin 5-phosphates as potential fungicides." Canadian Journal of Chemistry 75, no. 6 (1997): 712–15. http://dx.doi.org/10.1139/v97-085.

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Two hydantoin analogs were synthesized utilizing an organometallic allylation reaction in aqueous solution as a key step. One of the derivatives showed weak fungicidal activity. Keywords: hydantoin, fungicide, phosphate.

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5

Divjak, Natalija, Nebojsa Banjac, Natasa Valentic, and Gordana Uscumlic. "Synthesis, structure and solvatochromism of 5-methyl-5-(3-or 4-substituted phenyl)hydantoins." Journal of the Serbian Chemical Society 74, no. 11 (2009): 1195–205. http://dx.doi.org/10.2298/jsc0911195d.

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Several 5-methyl-5-(3- or 4-substituted phenyl)hydantoins were prepared and their ultraviolet absorption spectra were recorded in the region 200-400 nm in twelve solvents of different polarity. The effect of solvent dipolarity/ polarizability and solvent/solute hydrogen bonding interactions were analyzed by means of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The lipophilic activity of the investigated hydantoins was estimated by calculation of log P values with Advanced Chemistry Development Software. The calculated values of log P were correlated with

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6

Trisovic, Nemanja, Gordana Uscumlic, and Slobodan Petrovic. "Hydantoins: Synthesis, properties and anticonvulsant activity." Chemical Industry 63, no. 1 (2009): 17–31. http://dx.doi.org/10.2298/hemind0901017t.

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Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.

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7

Kaválek, Jaromír, Vladimír Macháček, Gabriela Svobodová, and Vojeslav Štěrba. "Base catalyzed cyclization of substituted esters of hydantoic and thiohydantoic acids." Collection of Czechoslovak Chemical Communications 51, no. 2 (1986): 375–90. http://dx.doi.org/10.1135/cccc19860375.

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Base catalyzed cyclization rates have been measured of 22 derivatives of hydantoic and thiohydantoic acid esters in water and methanol. The cyclization of methyl and ethyl esters of hydantoic and 5-methylhydantoic acids is accompanied by hydrolysis of the ester group, whereas with the other derivatives the hydrolysis does not take place. Hydrolysis of the cyclization products (hydantoin and thiohydantoin derivatives) is not significant under the kinetic conditions. The cyclization of methyl ester of 5-phenylhydantoic acid in methanol is reversible; the equilibrium mixture contains 30% of the s

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8

Abadi, Ashraf H., Jochen Lehmann, Gary A. Piazza, Mohammad Abdel-Halim та Mohamed S. M. Ali. "Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors". International Journal of Medicinal Chemistry 2011 (23 лютого 2011): 1–9. http://dx.doi.org/10.1155/2011/562421.

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Two series of fused tetrahydro-β-carboline hydantoin and tetrahydro-β-carboline thiohydantoin derivatives with a pendant 2,4-dimethoxyphenyl at position 5 were synthesized, and chiral carbons at positions 5 and 11a swing from R,R to R,S, S,R, and S,S. The prepared analogues were evaluated for their capacity to inhibit phosphodiesterase 5 (PDE5) isozyme. The R absolute configuration of C-5 in the β-carboline hydantoin derivatives was found to be essential for the PDE5 inhibition. Chiral carbon derived from amino acid even if of the S configuration (L-tryptophan) may lead to equiactive or more a

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9

Ahmad, Roshan, Rukhsana Jabeen, Mohammad Zia-ul-Haq, Humaira Nadeem, Helmut Duddeck, and Eugen J. Verspohl. "Chiral Aryl Sulfonyl Hydantoins as Hypoglycemic Agents." Zeitschrift für Naturforschung B 55, no. 2 (2000): 203–7. http://dx.doi.org/10.1515/znb-2000-0212.

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Some novel chiral sulfonyl hydantoin derivatives 2a-e and 3 a-e have been prepared. p-Toluenesulfonyl chloride on treatment with L-amino acids in presence of K2CO3/H2O yielded N-(p-toluensulfonyl-)amino acids 1a - e which were cyclized in presence of NH4-SCN Ac2O to afford 1-(p-toluenesulfonyl)-5-substituted-2-thiohydantoins 2a-e. These compounds were oxidized with HNO3 to yield 1-(p-toluenesulfonyl)-5-substituted hydantoins 3a-e. The enantiomeric ratios of 3a-e were determined by 1H NMR spectroscopy using Eu(hfc)3. The antidiabetic activity of 3a-d has been determined.

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10

Lazic, Anita, Natasa Valentic, Nemanja Trisovic, Slobodan Petrovic, and Gordana Uscumlic. "Synthesis, structure and biological properties of active spirohydantoin derivatives." Chemical Industry 70, no. 2 (2016): 177–99. http://dx.doi.org/10.2298/hemind150205025l.

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Spirohidantoins represent an pharmacologically important class of heterocycles since many derivatives have been recognized that display interesting activities against a wide range of biological targets. First synthesis of cycloalkanespiro-5-hydantoins was performed by Bucherer and Lieb 1934 by the reaction of cycloalkanone, potassium cyanide and ammonium-carbonate at reflux in a mixture of ethanol and water. QSAR (Quantitative Structure-Activity Relationship) studies showed that a wide range of biological activities of spirohydantoin derivatives strongly depend upon their structure. This paper

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11

Fujisaki, Fumiko, Hatsumi Aki, Ayumi Naito, et al. "Synthesis of New 5-Substituted Hydantoins and Symmetrical Twin-Drug Type Hydantoin Derivatives." Chemical and Pharmaceutical Bulletin 62, no. 5 (2014): 429–38. http://dx.doi.org/10.1248/cpb.c14-00017.

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12

Bhusainahalli, Vedamurthy M., Antonio Rescifina, Nunzio Cardullo, Carmela Spatafora, and Corrado Tringali. "Bio-activated intramolecular anti-aza-Michael addition: stereoselective synthesis of hydantoin derivatives." New Journal of Chemistry 42, no. 22 (2018): 18348–57. http://dx.doi.org/10.1039/c8nj02909a.

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13

Su, Ma, Donglin Xia, Peng Teng, et al. "Membrane-Active Hydantoin Derivatives as Antibiotic Agents." Journal of Medicinal Chemistry 60, no. 20 (2017): 8456–65. http://dx.doi.org/10.1021/acs.jmedchem.7b00847.

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14

Volonterio, Alessandro, Maria Bellucci, Massimo Frigerio, and Tommaso Marcelli. "Multicomponent Synthesis of N-Carbamoyl Hydantoin Derivatives." Synlett 24, no. 06 (2013): 727–32. http://dx.doi.org/10.1055/s-0032-1318432.

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15

Oh, Chang-Hyun, Ki-Soo Lee, Eun-Joo Roh, Soon-Kyung Kwon, and Jung-Hyuck Cho. "Synthesis of new hydantoin-3-ethanethiol derivatives." Archives of Pharmacal Research 17, no. 4 (1994): 281–83. http://dx.doi.org/10.1007/bf02980462.

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16

Kucwaj-Brysz, Katarzyna, Rafał Kurczab, Ewa Żesławska, et al. "The role of aryl-topology in balancing between selective and dual 5-HT7R/5-HT1A actions of 3,5-substituted hydantoins." MedChemComm 9, no. 6 (2018): 1033–44. http://dx.doi.org/10.1039/c8md00168e.

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17

Potdar, Shweta, Nikita Pal, Pratibha Sharma, and Ashok Kumar. "The catalytic influence of phosphotungstic acid-functionalized Fe3O4 MNPs blended with TiO2 on the synthesis of novel spiro-acridines and the evaluation of their medicinal potential through molecular docking studies." RSC Advances 10, no. 72 (2020): 44442–52. http://dx.doi.org/10.1039/d0ra06975b.

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This manuscript describes an effective and rapid three-component synthesis of a novel series of spiro-acridine derivatives by integrating the pharmacologically dynamic hydantoin–phenytoin as the prime synthetic equivalent.

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18

Fujisaki, Fumiko, Hatsumi Aki, Ayumi Naito, et al. "ChemInform Abstract: Synthesis of New 5-Substituted Hydantoins and Symmetrical Twin-Drug Type Hydantoin Derivatives." ChemInform 45, no. 43 (2014): no. http://dx.doi.org/10.1002/chin.201443126.

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19

OHTANI, Yutaka, Takashi SAITO, Kenji SUGAWARA, et al. "Coordination Equilibria of Hydantoin Derivatives with Gold Ions." Journal of The Surface Finishing Society of Japan 56, no. 8 (2005): 479–80. http://dx.doi.org/10.4139/sfj.56.479.

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20

Colacino, Evelina, Frédéric Lamaty, Jean Martinez, and Isabelle Parrot. "Microwave-assisted solid-phase synthesis of hydantoin derivatives." Tetrahedron Letters 48, no. 30 (2007): 5317–20. http://dx.doi.org/10.1016/j.tetlet.2007.05.084.

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21

Kieć-Kononowicz, K., and E. Szymańska. "Antimycobacterial activity of 5-arylidene derivatives of hydantoin." Il Farmaco 57, no. 11 (2002): 909–16. http://dx.doi.org/10.1016/s0014-827x(02)01292-2.

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22

Braña, Miguel F., Mercedes Garrido, María L. López Rodriguez, Pilar Miguel, M. José Morcillo та A. Riaño. "Synthesis of new derivatives of β-carboline-hydantoin". Journal of Heterocyclic Chemistry 27, № 3 (1990): 703–6. http://dx.doi.org/10.1002/jhet.5570270342.

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23

Bichel, Jørgen. "Hydantoin Derivatives and Malignancies of the Haemopoietic System." Acta Medica Scandinavica 198, no. 1-6 (2009): 327–28. http://dx.doi.org/10.1111/j.0954-6820.1975.tb19550.x.

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24

Jakšea, Renata, Vesna Krošelj, Simon Rečnik, et al. "Stereoselective Synthesis of 5-[(Z)-Heteroarylmethylidene] Substituted Hydantoins and Thiohydantoins as Aplysinopsin Analogs." Zeitschrift für Naturforschung B 57, no. 4 (2002): 453–59. http://dx.doi.org/10.1515/znb-2002-0411.

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3-Substituted 5-[(Z)-heteroarylmethylidene]imidazolidine-2,4-dione and 5-[(Z)-heteroarylmethylidene]- 2-thiooxoimidazolidin-4-one derivatives were prepared stereoselectively by coupling of 5-(dimethylamino)methylidene substituted hydantoin and thiohydantoin derivatives with carbocyclic and heterocyclic C-nucleophiles.Configuration around the exocyclic C=C double bond was determined by NMR, using NOESY and 2D HMBC techniques.

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25

Witek, Karolina, Gniewomir Latacz, Aneta Kaczor, et al. "Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in Staphylococcus epidermidis." Molecules 25, no. 17 (2020): 3788. http://dx.doi.org/10.3390/molecules25173788.

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Herein, 15 phenylpiperazine 3-benzyl-5,5-dimethylhydantoin derivatives (1–15) were screened for modulatory activity towards Msr(A) efflux pump present in S. epidermidis bacteria. Synthesis, crystallographic analysis, biological studies in vitro and structure–activity relationship (SAR) analysis were performed. The efflux pump inhibitory (EPI) potency was determined by employing ethidium bromide accumulation assay in both Msr(A) efflux pump overexpressed (K/14/1345) and deficient (ATCC 12228) S. epidermidis strains. The series of compounds was also evaluated for the capacity to reduce the resis

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26

Bolla, Ratna Sekhar, Narasimha Murthy Gandikota та Ivaturi Venkata Kasi Viswanath. "Synthesis of Deuterium Labeled 5, 5-Dimethyl-3-(α, α, α-trifluoro-4-nitro-m-tolyl) Hydantoin". Current Radiopharmaceuticals 12, № 1 (2019): 82–87. http://dx.doi.org/10.2174/1874471012666181130162731.

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Objective: Stable and non-radioactive isotope labeled compounds gained significance in recent drug discovery and other various applications such as bio-analytical studies. The modern bioanalytical techniques can study the adverse therapeutic effects of drugs by comparing isotopically labeled internal standards. A well-designed labeled compound can provide high-quality information about the identity and quantification of drug-related compounds in biological samples. This information can be very useful at key decision points in drug development. In this study, we tried to synthesize Nilutamide-

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27

Aganyants, Hovsep, Pierre Weigel, Yeranuhi Hovhannisyan, et al. "Rational Engineering of the Substrate Specificity of a Thermostable D-Hydantoinase (Dihydropyrimidinase)." High-Throughput 9, no. 1 (2020): 5. http://dx.doi.org/10.3390/ht9010005.

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D-hydantoinases catalyze an enantioselective opening of 5- and 6-membered cyclic structures and therefore can be used for the production of optically pure precursors for biomedical applications. The thermostable D-hydantoinase from Geobacillus stearothermophilus ATCC 31783 is a manganese-dependent enzyme and exhibits low activity towards bulky hydantoin derivatives. Homology modeling with a known 3D structure (PDB code: 1K1D) allowed us to identify the amino acids to be mutated at the substrate binding site and in its immediate vicinity to modulate the substrate specificity. Both single and do

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28

Chylińska, Marta, Marta Ziegler-Borowska, Halina Kaczmarek, Aleksandra Burkowska, Maciej Walczak, and Przemysław Kosobucki. "Synthesis and biocidal activity of novel N-halamine hydantoin-containing polystyrenes." e-Polymers 14, no. 1 (2014): 15–25. http://dx.doi.org/10.1515/epoly-2013-0010.

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AbstractThree homopolymers containing hydantoin substituents were obtained by chemical modification of reactive p-chloromethylated polystyrene. The prepared polymers were chlorinated to yield N-halamine materials with biocidal properties. The chemical structure of polymers was characterized by Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. All of the hydantoin polymers are insoluble in water and common organic solvents. Microbiological investigations prove the high biocidal activity of the obtained chlorinated polystyrene derivatives containing spirohydant

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29

SASAKI, Haruko. "Gold（I）Complexes of Hydantoin Derivatives and Their Properties." Journal of The Surface Finishing Society of Japan 71, no. 12 (2020): 828–32. http://dx.doi.org/10.4139/sfj.71.828.

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30

Szymańska, Ewa, and Katarzyna Kieć-Kononowicz. "Antimycobacterial activity of 5-arylidene aromatic derivatives of hydantoin." Il Farmaco 57, no. 5 (2002): 355–62. http://dx.doi.org/10.1016/s0014-827x(01)01194-6.

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31

Bellucci, Maria Cristina, Massimo Frigerio, Tommaso Marcelli, and Alessandro Volonterio. "ChemInform Abstract: Multicomponent Synthesis of N-Carbamoyl Hydantoin Derivatives." ChemInform 44, no. 29 (2013): no. http://dx.doi.org/10.1002/chin.201329131.

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32

Jiang, Lu, and Bin Zeng. "Derivatives of Hydantoin: Synthesis and Antiproliferative Activity on HepG2 Cancer Cell Line." Advanced Materials Research 893 (February 2014): 512–15. http://dx.doi.org/10.4028/www.scientific.net/amr.893.512.

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Based on the study of rhodanine derivative WL-276,some novel compounds were synthesized,and their anti-tumor effects were screened by MTT method. Hydantoin is rhodanine of electronic derivative. Compounds of 3a-3d were obtained by Aldol reaction, whose structures were confirmed by 1H-NMR. Furthermore, preliminary pharmacological results suggested that compounds 2a had strong inhibitory effects on the proliferation of HepG2 tumor cells.

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33

Dios, Alfonso de, Maria Luz de la Puente, Alfonso Rivera-Sagredo, and Juan Felix Espinosa. "Structural and conformational studies of 5-(1H-pyrrol-2-ylmethylene)-substituted imidazolidine-2,4-diones and thiazolidine-2,4-diones." Canadian Journal of Chemistry 80, no. 10 (2002): 1302–7. http://dx.doi.org/10.1139/v02-175.

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Some imidazolidine-2,4-dione (hydantoin) and thiazolidine-2,4-dione (TZD) derivatives with a 1H-pyrrol-2-ylmethylene substituent at the 5-position (18) have been synthesized via an aldol condensation reaction. A mixture of Z- and E- stereoisomers was obtained, as confirmed by HPLC and NMR studies. Assignment of the stereochemistry was achieved through chemical shift knowledge, NOE, and 3JH,C data. The conformation of the molecules depends on the configuration at the double bond. While the (NH,C cis) form is the most stable conformer for the E-isomer, the (NH,C trans) form is the preferred con

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34

Abd Elhady, Hebe, Somia El Desoky, Hossa Al-Shareef, and Rasha El-mekawy. "SYNTHESIS, REACTIONS, AND APPLICATIONS OF HYDANTOIN AND 2-THIOHYDANTOIN DERIVATIVES." Acta Poloniae Pharmaceutica - Drug Research 76, no. 6 (2019): 971–86. http://dx.doi.org/10.32383/appdr/112124.

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35

OHTANI, Yutaka, Kenji SUGAWARA, Kenji NEMOTO, et al. "Investigation of Hydantoin Derivatives as Complexing Agent for Gold Plating." Journal of The Surface Finishing Society of Japan 55, no. 12 (2004): 933–36. http://dx.doi.org/10.4139/sfj.55.933.

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36

Ušćumlić, G., and M. Mišić- Vuković. "Substituent effect on CO stretching vibrations in hydantoin derivatives." Journal of Molecular Structure 266 (March 1992): 315–20. http://dx.doi.org/10.1016/0022-2860(92)80085-v.

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37

Hudkins, Robert L., Diane L. DeHaven-Hudkins, and Peter Doukas. "Design of dual acting anticonvulsant-antimuscarinic succinimide and hydantoin derivatives." Bioorganic & Medicinal Chemistry Letters 7, no. 8 (1997): 979–84. http://dx.doi.org/10.1016/s0960-894x(97)00143-1.

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38

Lotfy Aly, Youssef. "5-Pyrenylidene-hydantoin, 2-thiohydantoin derivatives: synthesis,S- andN-alkylation." Journal of Sulfur Chemistry 28, no. 4 (2007): 371–82. http://dx.doi.org/10.1080/17415990701385945.

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39

Lee, Jinho, Jonghyun Kim, Jong Sung Koh, Hyun-Ho Chung, and Kyoung-Hee Kim. "Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase." Bioorganic & Medicinal Chemistry Letters 16, no. 7 (2006): 1954–56. http://dx.doi.org/10.1016/j.bmcl.2005.12.074.

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40

Obradović, Ana, Miloš Matić, Branka Ognjanović, et al. "Anti-Tumor Mechanisms of Novel 3-(4-Substituted Benzyl)-5-Isopropil-5- Phenylhydantoin Derivatives in Human Colon Cancer Cell Line." Anti-Cancer Agents in Medicinal Chemistry 19, no. 12 (2019): 1491–502. http://dx.doi.org/10.2174/1871520619666190425180610.

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Background: Hydantoin and its newly synthesized derivatives have recently become a focus of interest due to their numerous biological activities and newly emerging beneficial effects in different pathological conditions, including cancer. Objective: The aim of this study was to evaluate the possible anti-tumor mechanisms of a series of newly synthesized 3-(4-substituted benzyl)-5-isopropyl-5-phenylhydantoin derivatives in different aspects of cell physiology of human colon cancer cell line, HCT-116. Methods: The increasing concentrations of derivatives (0.01µM up to 100µM) were applied to cell

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41

Zagórska, Agnieszka, Anna Czopek, Anna Jaromin, et al. "Design, Synthesis, and In Vitro Antiproliferative Activity of Hydantoin and Purine Derivatives with the 4-Acetylphenylpiperazinylalkyl Moiety." Materials 14, no. 15 (2021): 4156. http://dx.doi.org/10.3390/ma14154156.

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Cancer represents one of the most serious health problems and the second leading cause of death around the world. Heterocycles, due to their prevalence in nature as well as their structural and chemical diversity, play an immensely important role in anti-cancer drug discovery. In this paper, a series of hydantoin and purine derivatives containing a 4-acetylphenylpiperazinylalkyl moiety were designed, synthesized, and biologically evaluated for their anticancer activity on selected cancer cell lines (PC3, SW480, SW620). Compound 4, a derivative of 3′,4′-dihydro-2′H-spiro[imidazolidine-4,1′-naph

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42

Lytvyn, I., O. Kulynych, V. Starova, P. Mykhailiuk, and O. Zaporozhets. "Fluorescence Properties Of Fluorine-Containing Hydantoin Derivatives As Potential Fluorescent Probes." METHODS AND OBJECTS OF CHEMICAL ANALYSIS 11, no. 1 (2016): 11–15. http://dx.doi.org/10.17721/moca.2016.11-15.

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43

Groutas, W. C., M. A. Stanga, J. C. Castrisos, and E. J. Schatz. "Hydantoin Derivatives. A New Class of Inhibitors of Human Leukocyte Elastase." Journal of Enzyme Inhibition 3, no. 3 (1990): 237–43. http://dx.doi.org/10.3109/14756369009035842.

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44

Ma, Bao-De, Sheng-Hua Du, Yu Wang, et al. "Synthesis of chiral hydantoin derivatives by homogeneous Pd-catalyzed asymmetric hydrogenation." Tetrahedron: Asymmetry 28, no. 1 (2017): 47–53. http://dx.doi.org/10.1016/j.tetasy.2016.10.006.

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45

Ahluwalia, V. K., Bhupinder Mehta, and Manju Rawat. "A New Approach for the Conversion of Thiohydantoin to Hydantoin Derivatives." Synthetic Communications 22, no. 1 (1992): 145–50. http://dx.doi.org/10.1080/00397919208021085.

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46

Szymańska, Ewa, Katarzyna Kieć-Kononowicz, Anna Białecka, and Andrzej Kasprowicz. "Antimicrobial activity of 5-arylidene aromatic derivatives of hydantoin. Part 2." Il Farmaco 57, no. 1 (2002): 39–44. http://dx.doi.org/10.1016/s0014-827x(01)01172-7.

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47

Lee, Gun-Young, You-Suk Lee, Sang Man Koo, and Kee-Jung Lee. "ChemInform Abstract: Synthesis and X-Ray Crystal Structure of Hydantoin Derivatives." ChemInform 31, no. 17 (2010): no. http://dx.doi.org/10.1002/chin.200017126.

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48

Kuninobu, Yoichiro, Kou Kikuchi, and Kazuhiko Takai. "Manganese-catalyzed Synthesis of Hydantoin Derivatives from Terminal Alkynes and Isocyanates." Chemistry Letters 37, no. 7 (2008): 740–41. http://dx.doi.org/10.1246/cl.2008.740.

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49

Hiromi, Sano, Mio Shigeru, Kumagawa Yuko, et al. "Synthesis and Herbicidal Activity of Opened Hydantoin-ring Derivatives of Hydantocidin." Bioscience, Biotechnology, and Biochemistry 60, no. 7 (1996): 1198–200. http://dx.doi.org/10.1271/bbb.60.1198.

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Ahmed, A. H., A. Ebead, H. Afifi, and A. A. H. Abdel-Rahman. "Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives." Russian Journal of General Chemistry 89, no. 2 (2019): 357–63. http://dx.doi.org/10.1134/s1070363219020294.

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