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Journal articles on the topic 'Dermal fillers; facial aging; skin'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Kim, Jong Seo. "Changes in Dermal Thickness in Biopsy Study of Histologic Findings After a Single Injection of Polycaprolactone-Based Filler into the Dermis." Aesthetic Surgery Journal 39, no. 12 (2019): NP484—NP494. http://dx.doi.org/10.1093/asj/sjz050.

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AbstractBackgroundDuring aging, facial skin thins, atrophies, and loses elasticity. Subdermal filler injections can volumize and treat wrinkles but cannot directly change dermal thickness. Polycaprolactone (PCL) fillers can improve skin texture and quality through dermal thickening and inducing neocollagenesis. Through biopsy study, evidence of neocollagenesis will be introduced.ObjectivesIn this single-clinic prospective study, 13 patients received a single injection of diluted 0.5 cc of PCL filler in the facial dermis except the right temple area for intra-individual control study.MethodsA b

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Crowley, J. Sarah, Elizabeth Kream, Sabrina Fabi, and Steven R. Cohen. "Facial Rejuvenation With Fat Grafting and Fillers." Aesthetic Surgery Journal 41, Supplement_1 (2021): S31—S38. http://dx.doi.org/10.1093/asj/sjab014.

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Abstract Facial rejuvenation requires a multi-modality approach to address the sun damage, volume loss, and thinning of skin that occurs with aging. With age, the collagen fibrils that provide strength become fragmented and fibroblasts connections become weak, leading to skin laxity and loss of youthful skin. Fillers can lead to a more youthful appearance by providing volumetric support. Synthetic fillers such as hyaluronic acid products, calcium hydroxyapatite, polylactic acid, and polymethylmethacralate have bio-stimulatory affects, ranging from small effects on fibroblast production to prol

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Mohamed, Dalia A. "Dermal Filler types, Effect on soft tissue and Life Style correlation." Journal of Medicine and Health Sciences Research 3 (August 9, 2020): 1. http://dx.doi.org/10.21839/jmhsr.2020.v3.315.

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One of the most common manifestation in our time, especially among girls, is those procedures on the skin or maintaining or to modify some of the changes in the skin, such as those that come due to aging or any other cosmetic reasons. Fillers and Botox are two of the most popular procedures. Dermal fillers are effective treatments used to soften and reduce wrinkles and deep lines, fill out the cheeks and smooth facial contours. There are four main types of injectable dermal fillers, including fat, collagen, hyaluronic acid, and microsphere-containing carriers of another material such as polyme

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Urdiales-Gálvez, Fernando, Sandra Martín-Sánchez, Mónica Maíz-Jiménez, Antonio Castellano-Miralla, and Leonardo Lionetti-Leone. "Concomitant Use of Hyaluronic Acid and Laser in Facial Rejuvenation." Aesthetic Plastic Surgery 43, no. 4 (2019): 1061–70. http://dx.doi.org/10.1007/s00266-019-01393-7.

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AbstractBackgroundFacial aging is a process that involves many different changes. Therefore, in many patients, it may be necessary to perform a combined treatment. Botulinum toxin A and dermal fillers are the two most popular nonsurgical cosmetic procedures performed globally to treat age-associated changes. However, there are not many studies reporting the concomitant use of dermal fillers and laser technology for facial rejuvenation. This review aims to assess the concomitant use of dermal hyaluronic acid (HA) fillers and laser technology for facial rejuvenation.MethodsThe present updated co

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Melfa, Fabrizio, Daniela Siragusa, Daniela Caruso, Carmelo Lo Faro, Giovanni Francesco Nicoletti, and Raffaele Rauso. "At-home Cosmeceutical Application and Outpatient Treatments: A 3D Stepwise Facial Rejuvenation Approach." Open Access Macedonian Journal of Medical Sciences 8, B (2020): 1041–46. http://dx.doi.org/10.3889/oamjms.2020.5062.

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BACKGROUND: Aging affects the 3-dimensional structure of all the facial tissues: Bones, muscles, ligaments, adipose tissue, and skin. AIM: To customize minimally invasive treatments for facial rejuvenation, we present a standardized holistic approach characterized by at-home treatments in associations with outpatient procedures. METHODS: Forty-four patients underwent 3-dimensional stepwise facial rejuvenation and were evaluated prospectively. Each patient received a customized treatment plan based on a clinical examination and consultation. Treatment outcomes were evaluated from pa

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Fedorchenko, Yuliya. "PLATELET-RICH PLASMA IN ANTI-AGING AND AESTHETIC MEDICINE." Anti-Aging Eastern Europe 3, no. 4 (2024): 168–74. https://doi.org/10.56543/aaeeu.2024.3.4.01.

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Skin aging is a multifactorial process influenced by intrinsic and extrinsic factors, leading to structural and functional deterioration, including wrinkles, laxity, pigmentation, and barrier dysfunction. Platelet-Rich Plasma (PRP) has emerged as a novel regenerative therapy in anti-aging and aesthetic medicine due to its ability to stimulate collagen production, tissue repair, and neo-angiogenesis through autologous growth factors. PRP has demonstrated significant efficacy in improving skin texture, tone, and elasticity, particularly when combined with microneedling, dermal fillers, or fracti

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Fernandes Dos Santos Lima, Janaína, Lauscea Regina Veronezi, Marcia Vivianne Nogueira, et al. "MULTILAYER TREATMENT OF THE NASOGENIAN FROOD." Health and Society 3, no. 06 (2023): 517–36. http://dx.doi.org/10.51249/hs.v3i06.1799.

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Aging is a physiological process determined by various intrinsic and extrinsic factors, being a normal and inevitable process. A common complaint of the aging process is the crease of the nasolabial folds, popularly known as the “Chinese mustache”. With aging, the progressive ptosis of the malar fat and the overlying skin contribute to the deepening of the sulcus, but the depth also varies according to race, gender, age and weight. Since 1996, HA has been used by dermatologists and plastic surgeons for cosmetic purposes to fill in wrinkles, scars, increase lip volume and others. Although the d

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Keisy, Pinheiro Gualberto, Peres Sant'ana Raissa, and Gomes da Silva Júnior Genival. "ANÁLISE DOS BENEFÍCIOS E RISCOS DOS PRINCIPAIS PREENCHEDORES DÉRMICOS NA REVERSÃO DO ENVELHECIMENTO: UMA REVISÃO DE LITERATURA." REVISTA FT 28, no. 128 (2023): 09. https://doi.org/10.5281/zenodo.10207609.

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<strong>Objetivo:</strong> O presente estudo tem como objetivo analisar os benefícios e riscos dos principais preenchedores dérmicos na reversão do envelhecimento.<strong> Métodos: </strong>Trata-se de uma revisão de literatura, com abordagem qualitativa, baseado em analise bibliográfica através de pesquisa na literatura já existente, presentes artigos científicos.<strong> Resultados:</strong> Diante da demanda de soluções contra o envelhecimento facial, os preenchedores faciais passaram a ter destaque no meio estético. Essas substâncias se diferenciam entre si e apresentam diversas particular

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Fedorchenko, Yuliya. "ANTI-AGING COSMETIC PROCEDURES: BENEFITS AND RISKS." Anti-Aging Eastern Europe 3, no. 3 (2024): 135–40. http://dx.doi.org/10.56543/aaeeu.2024.3.3.04.

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The rising demand for aesthetic interventions reflects a broader cultural trend toward enhancing physical appearance and rejuvenation, fueled by technological advancements and increased accessibility of invasive and non-invasive cosmetic procedures. Skin aging, driven by a combination of genetic, hormonal, and environmental factors, results in visible changes such as wrinkles and reduced skin elasticity. The growing availability of cosmetic procedures, including botulinum toxin injections, dermal fillers, and surgical options like rhinoplasty and liposuction, underscores a shift in public atti

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Bravo, Bruna, Raquel Carvalho, Leonardo Bravo, Laís Penedo, and Mariana Elias. "Blending Hyaluronic Acid and Calcium Hydroxylapatite for Injectable Facial Dermal Fillers: A Clinical and Ultrasonography Assessment." Cosmetics 11, no. 2 (2024): 61. http://dx.doi.org/10.3390/cosmetics11020061.

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Both hyaluronic acid (HA) and calcium hydroxylapatite (CaHA) fillers have well-established indications in cosmetic medicine. Nevertheless, limited data are available on the effectiveness of combining CaHA and HA. The purpose of this report was to demonstrate the safety, tolerability, and clinical and ultrasonographic improvement of facial skin laxity using a blending technique that admixes HA and CaHA. Fifteen regular patients, including three men, between 25 and 71 years of age were reported. The participants were subjects who came regularly to the dermatologic office seeking a lifting effect

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Patel, Sagar, and Russell Kridel. "Cheek and Chin Implants to Enhance Facelift Results." Facial Plastic Surgery 33, no. 03 (2017): 279–84. http://dx.doi.org/10.1055/s-0037-1598055.

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AbstractThe traditional rhytidectomy addresses facial and neck aging as it relates to soft tissue laxity. The modern volumetric facelift provides optimal results by addressing not only skin laxity but also the loss of volume secondary to tissue atrophy and bony resorption. While multiple techniques including fat grafting, dermal fillers, and tissue resuspension are used to correct the tissue loss, alloplastic midface augmentation remains the most permanent method. In our practice we often address midface cheek hollowness or atrophy with the placement of submalar implants at the time of rhytide

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Gawey, Lauren, Nazanin Saedi, and Amelia Hausauer. "Neurotoxins and Combination Therapies." Dermatologic Surgery 50, no. 9S (2024): S85—S90. http://dx.doi.org/10.1097/dss.0000000000004359.

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BACKGROUND Facial aging involves multilevel changes, extending from the skin to deep support structures. A comprehensive treatment approach targeting the many aspects of facial dynamics and architecture is often necessary to achieve optimal correction, prevent changes before they occur, and/or help highlight inherited features. OBJECTIVE To explore the integration of botulinum toxin type A (BoNT-A) into multimodal aesthetic treatment plans. MATERIALS AND METHODS This article reviews evidence supporting the combination of BoNT-A with other minimally invasive cosmetic therapies, including dermal

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Oh, Seyeon, Nala Shin, Sang Ju Lee, Kuk Hui Son, and Kyunghee Byun. "Poly-L-Lactic Acid Filler Increases Adipogenesis and Adiponectin in Aged Subcutaneous Tissue." Polymers 17, no. 13 (2025): 1826. https://doi.org/10.3390/polym17131826.

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Poly-L-lactic acid (PLLA) filler, which increases volume and collagen synthesis, is used for skin rejuvenation. Subcutaneous adipose tissue (SAT) contains precursors that differentiate into mature adipocytes that secrete adiponectin, which modulates SAT function and increases adipogenesis. During aging, adiponectin and precursor cell functions decrease, reducing adipogenesis and facial volume. Adiponectin also increases collagen synthesis by stimulating fibroblasts. After hydrogen peroxide treatment to induce senescent adipocytes (3T3-L1) and aged skin, follow-up PLLA treatment increased adipo

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Cassuto, Daniel, Mara Delledonne, Giovanna Zaccaria, Immacolata Illiano, Andrea Maria Giori, and Gilberto Bellia. "Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data." BioMed Research International 2020 (June 22, 2020): 1–9. http://dx.doi.org/10.1155/2020/8159047.

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Background. At present, dermal fillers based on hyaluronic acid (HA) represent the most popular intervention of dermoesthetic medicine for the treatment of skin aging. Recent studies have shown that the combination of HA chains of different lengths and molecular weights improves tissue repair and regeneration through a synergistic mechanism. Profhilo® is a product available that has been on the market since 2015 and is based on stable, hybrid, and cooperative complexes (HyCoCos) produced by means of NAHYCO® Hybrid Technology, which is an innovative thermal process that rules out the use of any

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Zerbinati, Nicola, Edoardo D’Este, Annalisa De Silvestri, et al. "Efficacy of Pegylated Hyaluronic Acid Filler Enriched with Calcium Hydroxyapatite: A 24-Week Post-Market, Observational, Prospective, Open-Label, Single-Center Study." Journal of Functional Biomaterials 14, no. 7 (2023): 345. http://dx.doi.org/10.3390/jfb14070345.

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Recently, thanks to the greater discovery of the mechanisms of facial aging, an alternative to invasive plastic surgery has found space with less invasive aesthetic procedures, also based on an increasingly pressing request. We are specifically referring to dermal filler injection into or under the skin which leads to immediate rejuvenation and aesthetic improvements. In this study, we wanted to analyze the results obtained through the use of NEAUVIA Organic Stimulate, particularly with regard to its effectiveness, which is a cross-linked polymeric hydrogel, containing stabilized sodium hyalur

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Nethaji, Bharati Kannamma, Shivani Bhardwaj, Mahendra Singh Deora, et al. "The efficacy, safety, and application of platelet-poor plasma gel as an autologous dermal filler for esthetic enhancements and facial rejuvenation – A pilot study." Cosmoderma 5 (April 11, 2025): 42. https://doi.org/10.25259/csdm_221_2024.

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Objectives This study aims to evaluate the efficacy, safety, and application of platelet-poor plasma gel (PPP gel) as an autologous dermal filler for esthetic enhancements and facial rejuvenation. The primary objective is to assess the subjective esthetic improvement using the global esthetic improvement (GAI) scale and to evaluate the safety profile. The secondary objective is to evaluate the patients’ satisfaction scores to highlight both the psychological and esthetic benefits. Materials and Methods Thirty patients, who presented with various facial concerns such as tear trough deformity, f

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Agarwal, M. Patil CY* Kaushik I. and Dadhich S. "Fourth Generation Definisse® Threads for Facial Reshaping in Indian Subjects: Case Series." Journal of International Case Reports 2, no. 4 (2023): 235–38. https://doi.org/10.5281/zenodo.10630503.

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<strong>Abstract</strong> Definisse<sup>®</sup> double-needle threads are the latest fourth-generation poly (L-Lactide-co-ε-Caprolactone) (p(LA-CL)) threads. They are absorbable, monofilament, suspension barbed threads of synthetic origin with convergent bidirectional barbs. They exert mechanical action along with bio-stimulatory action inducing fibrosis giving a lifting effect that supports and repositions sagging facial tissue. Definisse<sup>®</sup> thread once inserted sub-dermally can last from 12 months to 15 months, with a lifting duration estimated to last between 30 mon

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Mehta, Preeya, Julie Bass Kaplan, and Sandy Zhang-Nunes. "Ischemic complications of dermal fillers." Plastic and Aesthetic Research 9, no. 10 (2022): 57. http://dx.doi.org/10.20517/2347-9264.2022.19.

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Dermal fillers have become increasingly popular as a cosmetic treatment for facial rejuvenation. Although these injections are generally considered to be safe, as the number of injections has increased, so has the rate of complications. Ischemic complications of fillers is critical and include vision loss, ophthalmoplegia, skin necrosis, and cerebral infarction. Knowing the anatomy well to optimally prevent and manage these serious complications. Prevention includes knowledge of the vascular anatomy of the facial area, as well as certain injection techniques such as aspiration, use of a smalle

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Mehta, Tristan, and Gowrav Gowda. "Treating nasolabial folds with dermal fillers: a holistic approach." Journal of Aesthetic Nursing 8, no. 6 (2019): 272–75. http://dx.doi.org/10.12968/joan.2019.8.6.272.

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There are multiple surgical and non-surgical ways to treat the nasolabial fold. Traditionally, the non-surgical way of treating nasolabial folds was through careful placement of hyaluronic acid fillers directly to the fold. Our understanding of the facial ageing process and facial anatomy has enabled us to evolve our technique so that nasolabial fold treatments are safer for patients and deliver better clinical outcomes. By treating nasolabial folds indirectly, by addressing the changes that occur through aging, the aesthetic practitioner can achieve more natural and effective reduction in the

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Berberi, Antoine, Bouchra Hjeij, Georges Aad, and Georges Aoun. "Infected Facial Tissue Fillers Caused by Dental Infection." Case Reports in Dentistry 2021 (November 22, 2021): 1–6. http://dx.doi.org/10.1155/2021/8661995.

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Injectable dermal fillers are widely used for facial rejuvenation; they help reshape the facial contours by treating volume loss due to aging changes. Facial fillers may become infected following a dental infection. In this report, we present a case of a 44-year-old female patient who presented with a swelling in her upper right buccal region following dental treatment of her second maxillary right premolar. After a thorough history, clinical, and radiological examinations, the diagnosis of infected dermal filler was made. The lesion was treated by association of two antibiotics (ciprofloxacin

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Liu, Michael H., David P. Beynet, and Nima M. Gharavi. "Overview of Deep Dermal Fillers." Facial Plastic Surgery 35, no. 03 (2019): 224–29. http://dx.doi.org/10.1055/s-0039-1688843.

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AbstractDermal fillers have become an integral part of both medical and cosmetic dermatology. Our expanding knowledge of the aging face has allowed us to shift the focus from skin-reduction lifting procedures to soft tissue augmentation. Within the past 5 years alone, nine new dermal fillers have been approved by the U.S. Food and Drug Administration for soft tissue augmentation. The rise in both the use and number of dermal fillers in recent years is a testament to their safety and efficacy. Dermal fillers can be broken down to three major types: temporary, semipermanent, and permanent. The f

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Ryu, Hyo-jeong, Seong-sung Kwak, Chang-hoon Rhee, Gi-hyeok Yang, Hwi-yeol Yun, and Won-ho Kang. "Model-Based Prediction to Evaluate Residence Time of Hyaluronic Acid Based Dermal Fillers." Pharmaceutics 13, no. 2 (2021): 133. http://dx.doi.org/10.3390/pharmaceutics13020133.

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Dermal fillers are gel-type substances for nonsurgical medical-device use to achieve facial rejuvenation. Currently, the most widely used skin fillers are hyaluronic-acid-based dermal fillers. This study aimed to explain the change in the volume of injected dermal fillers by developing a mathematical kinetic model for various dermal fillers. The kinetics of the injected fillers were separated by a biphasic phenomenon. We attributed an increase in filler volume to the hydration of hyaluronic acid molecules and injection-site reaction and a decrease in volume to enzyme-mediated degradation. To e

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Prasad, Prathibha, Al-Moutassem Billah Khair, Safa Mohammad Najib, and Shahrzad Iman Talab. "A Review on the Expanding Role of Dentists in Facial Esthetics." Journal of Pharmacy and Bioallied Sciences 16, Suppl 5 (2024): S4230—S4234. https://doi.org/10.4103/jpbs.jpbs_718_24.

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ABSTRACT Dentists’ role in facial esthetics is growing, with advancements in cosmetic procedures, such as Botox and dermal fillers. Understanding the range of practitioners and their professional backgrounds is crucial for addressing risks. Data collection and analysis was done to retrieve scholarly papers using databases, such as PubMed and advanced Google search, and analyze. Currently, the role of dentists in facial beauty is gaining huge interest. This is a new and controversial issue in this era of society. Botox and dermal fillers help general dentists create a harmonious smile by contro

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Bravo, Bruna S. F., Leonardo G. Bravo, Bárbara F. Gouvea, et al. "Calcium Hydroxylapatite-Based Fillers in Facial Rejuvenation: A Prospective, Single-Center, Unblinded Comparative Outcome Study of Radiesse® vs. Rennova® Diamond Intense." Journal of Clinical Medicine 14, no. 12 (2025): 4072. https://doi.org/10.3390/jcm14124072.

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Background/Objectives: Calcium hydroxylapatite (CaHA)-based dermal fillers are widely used in esthetic medicine due to their dual volumizing and biostimulatory properties. Despite their rising popularity, comparative clinical outcome data evaluating different CaHA fillers remain limited. This prospective, single-center, unblinded study aimed to establish the effectiveness of the CaHA filler Rennova® Diamond Intense via comparison to the well-established CaHA filler Radiesse® in terms of clinical performance, safety, and patient satisfaction. Methods: Thirty patients (28 female, 2 male) underwe

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Arora, Gulhima. "Fillers for aesthetics on the face – Newer perspectives." Cosmoderma 1 (May 17, 2021): 6. http://dx.doi.org/10.25259/csdm_6_2021.

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Dermal fillers are a cornerstone of the aesthetic treatments of the face. They have evolved over many aspects since their initial use. Facial fillers are not just used for anti-aging to restore volume, but are now also used for contouring, enhancing facial features, and changing the emotional attributes of the face. Newer techniques and approaches have been proposed for greater predictability of results and minimum complications. Newer composite filler materials and a resurgence of older materials have taken place with better understanding of the science behind them. With more use of facial fi

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Samizadeh, Souphiyeh, and Koenraad De Boulle. "Complications of toxins and fillers in facial aesthetics." Primary Dental Journal 12, no. 3 (2023): 65–72. http://dx.doi.org/10.1177/20501684231197717.

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Dermal filler and botulinum toxin injections are among the most performed non-invasive procedures for rejuvenation and contouring, internationally. Although most dermal fillers and approved botulinum toxins are well tolerated with a high safety profile, adverse events and/or complications can happen. Injection-related sequelae and side effects are usually rare, mild, transient, and self-limiting in nature. However, devastating and life-changing complications, such as intravascular occlusion, skin necrosis, permanent visual impairment, and stroke, have been reported. Risk reduction measures inc

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Gadallah, Ahmed, Adnan Gamal Etman, and Mohamed Mamdouh Abd Elhalim. "Facial Contouring after Permanent Filler Removal with Combined Facelift and Fat Grafting: A Case Series." Plastic and Reconstructive Surgery - Global Open 11, no. 12 (2023): e5456. http://dx.doi.org/10.1097/gox.0000000000005456.

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Background: Aesthetic procedures for addressing aging range from simple injection of dermal fillers to facelift surgery. The last few decades have witnessed the development of diverse techniques to minimize facial wrinkles, volumize the face, and restore a youthful appearance. For example, fillers are a group of compounds used for cosmetic and reconstructive purposes, especially related to the face. Therefore, this study aimed to demonstrate specific cases where problematic dermal fillers were evacuated in combination with facelift procedures and fat grafting. It therefore demonstrates means t

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Nassar, AA, and AK Demyati. "Understanding Public Awareness and Practices of Nonsurgical Facial Dermal Fillers: A Cross-Sectional Study in Saudi Arabia." Nigerian Journal of Clinical Practice 27, no. 4 (2024): 528–33. http://dx.doi.org/10.4103/njcp.njcp_12_24.

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ABSTRACT Background: Dermal fillers augment soft tissues by replacing lost volume in the skin or subcutaneous fat. Dentists and other professionals utilize or recommend facial fillers for cosmetic and therapeutic purposes. Aims: This study aims to investigate public awareness regarding using nonsurgical facial dermal fillers in Saudi Arabia. Methods and Material: A cross-sectional study was conducted using an online self-administered questionnaire distributed to a total of 400 males and females through social media platforms. The participants reside in Mecca, Saudi Arabia. Descriptive statisti

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Bocsa, Gabriela. "A comprehensive approach to skin rejuvenation with Neauvia smart combination therapy." Journal of Aesthetic Nursing 13, no. 4 (2024): 124–28. http://dx.doi.org/10.12968/joan.2024.0015.

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Aesthetic medicine extends beyond just correction, evolving into prevention strategies for aging. This case study highlights the revolutionary potential of Neauvia dermal fillers in skin rejuvenation and enhancement. Unlike conventional hyaluronic acid fillers, Neauvia uses PEG (polyethylene glycol), a biocompatible polymer, ensuring exceptional durability and longevity. Moreover, its PEG-based formulation offers thermal stability, enabling synergistic use with energy-based devices like LaserMe. Through the SCT (Smart Combination Therapy) Protocol, combining Neauvia dermal fillers, Hydro Delux

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Wollina, Uwe, and Alberto Goldman. "Filler Migration after Facial Injection—A Narrative Review." Cosmetics 10, no. 4 (2023): 115. http://dx.doi.org/10.3390/cosmetics10040115.

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Background: The injection of dermal fillers for facial esthetics has become a very popular procedure. Although usually safe in the hands of the experienced user, filler injections may bear a risk of unwanted side effects. Material and Methods: This is a narrative review of dermal filler migration after facial injections. We performed research on the literature on Pubmed and Google Scholar. Inclusion criteria were observational studies, case reports, and clinical trials which investigated the association of facial filler injections to filler migration. Animal studies have not been considered. I

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Ciancio, Francesco, Maria Stella Tarico, Giuseppe Giudice, and Rosario Emanuele Perrotta. "Early hyaluronidase use in preventing skin necrosis after treatment with dermal fillers: Report of two cases." F1000Research 7 (September 3, 2018): 1388. http://dx.doi.org/10.12688/f1000research.15568.1.

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Injection of dermal fillers, like hyaluronic acid (HA), is a safe procedure, with few and transient side effects such as erythema, bruising and swelling etc. The aim of this report is to provide our protocol for the early treatment of necrotic complications after facial treatment with dermal fillers. We present two cases of skin suffering of the face after dermal infiltration of HA, treated successfully with our early protocol. Our protocol includes the early infiltration of hyaluronidase in the treated areas. We start with infiltration of hyaluronidase distributed over the area to be treated

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Ciancio, Francesco, Maria Stella Tarico, Giuseppe Giudice, and Rosario Emanuele Perrotta. "Early hyaluronidase use in preventing skin necrosis after treatment with dermal fillers: Report of two cases." F1000Research 7 (April 3, 2019): 1388. http://dx.doi.org/10.12688/f1000research.15568.2.

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Injection of dermal fillers, like hyaluronic acid (HA), is a safe procedure, with few and transient side effects such as erythema, bruising and swelling etc. The aim of this report is to provide our protocol for the early treatment of necrotic complications after facial treatment with dermal fillers. We present two cases of skin suffering of the face after dermal infiltration of HA, treated successfully with our early protocol. Our protocol includes the early infiltration of hyaluronidase in the treated areas. We start with infiltration of hyaluronidase distributed over the area to be treated

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Sedush, Nikita G., Kirill T. Kalinin, Pavel N. Azarkevich, and Antonina A. Gorskaya. "Physicochemical Characteristics and Hydrolytic Degradation of Polylactic Acid Dermal Fillers: A Comparative Study." Cosmetics 10, no. 4 (2023): 110. http://dx.doi.org/10.3390/cosmetics10040110.

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Dermal fillers have gained significant attention in the field of aesthetic medicine due to their ability to restore volume and correct facial wrinkles. Even though such formulations have similar compositions, they can have different microstructure and molecular characteristics, which in turn affect the biodegradation profile. This study presents the results of an investigation of the physicochemical characteristics of four dermal fillers from different manufacturers (Sculptra®, Gana V®, AestheFill®, and Repart PLA®). The molecular and supramolecular characteristics of polylactic acid (L/D isom

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Braz, André, and Camila Cazerta de Paula Eduardo. "The Facial Shapes in Planning the Treatment with Injectable Fillers." Indian Journal of Plastic Surgery 53, no. 02 (2020): 230–43. http://dx.doi.org/10.1055/s-0040-1715554.

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Abstract Introduction The facial beauty is not easy to define, yet it is paramount to assess the needs of each patient to propose an appropriate treatment plan that will provide beautification or rejuvenation in a natural-looking fashion.One of the beauty aspects easily recognized is the face shape, which can give a perception of age, gender, and attractiveness, and reflects the facial anatomical structure. Because addressing the structure of the face is the basis for the aesthetic approach with dermal fillers, we find the identification of the patient’s face shape to be a very good starting p

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Janovskiene, Audra, Deividas Chomicius, Dominykas Afanasjevas, Zygimantas Petronis, Dainius Razukevicius, and Egle Jagelaviciene. "Safety and Potential Complications of Facial Wrinkle Correction with Dermal Fillers: A Systematic Literature Review." Medicina 61, no. 1 (2024): 25. https://doi.org/10.3390/medicina61010025.

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Background and Objectives: The history of facial fillers is very broad, ranging from the use of various materials to modern technologies. Although procedures are considered safe, complications such as skin inflammation, infection, necrosis, or swelling may occur. It is crucial for specialists to be adequately prepared, inform patients how to prepare for corrective procedures, adhere to high safety standards, and continually educate. The goal of this systematic review is to identify complications arising during facial wrinkle correction procedures, as well as to explore safety and potential pre

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Shin, Jung-Won, Soon-Hyo Kwon, Ji-Young Choi, et al. "Molecular Mechanisms of Dermal Aging and Antiaging Approaches." International Journal of Molecular Sciences 20, no. 9 (2019): 2126. http://dx.doi.org/10.3390/ijms20092126.

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The dermis is primarily composed of the extracellular matrix (ECM) and fibroblasts. During the aging process, the dermis undergoes significant changes. Collagen, which is a major component of ECM, becomes fragmented and coarsely distributed, and its total amount decreases. This is mainly due to increased activity of matrix metalloproteinases, and impaired transforming growth factor-β signaling induced by reactive oxygen species generated during aging. The reduction in the amount of collagen hinders the mechanical interaction between fibroblasts and the ECM, and consequently leads to the deteri

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Prager, Welf. "Injektionstechnik, individuelle Physiologie und Charakteristika des Fillers - das A und O ästhetischer Behandlungen." Kompass Dermatologie 6, no. 2 (2018): 91–92. http://dx.doi.org/10.1159/000487791.

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Dermal filler and toxin injections have become the most frequently performed aesthetic procedures, offering patients rejuvenation and enhancement, with minimal downtime. The quality of the post-injection result and frequency of adverse events is related to the training, technical skill, and aesthetic and clinical judgment of the injector. Any provider performing injectable treatments should have a comprehensive understanding of facial aesthetics and facial anatomy, and how it is impacted by aging; as well as the available injectate capabilities and characteristics. They should be capable of sk

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Ivanjac, Filip, and Tanja Radenkov. "Correction of post traumatically scarred upper lip with hyaluron filler." Srpski arhiv za celokupno lekarstvo, no. 00 (2020): 82. http://dx.doi.org/10.2298/sarh191218082i.

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Introduction. It is generally known that dermal fillers are widely used in anti-aging medicine, to provide volume in healthy skin and mucous tissue. Fillers can also be successfully used with concave scars in order to lift the tissue and to give third dimension to the retracted skin surface. The aim of this case report was to show successful non-surgical treatment with hyaluron filler of the post traumatically deformed upper lip. Case outline. We report a case of a woman, with asymmetric partly incompetent upper lip, after trauma and primary surgical reconstruction. After almost 12 years, reco

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Majewski, George P. "Dermal-Epidermal Junction Proteins: A Useful Target for Addressing Age-Related Changes in Facial Skin." Clinical Dermatology & Therapy 9, no. 1 (2023): 1–3. http://dx.doi.org/10.24966/cdt-8771/100119.

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Skin aging is a natural physiological process that occurs due to intrinsic and extrinsic factors. Intrinsic aging of the skin is a well-balanced genetic process affected due to degeneration of skin tissues, hormonal changes, and a natural inability to repair skin damage [1]. Extrinsic factors involve modifiable lifestyle and environmental factors such as smoking, pollution, poor nutrition, and prolonged sun exposure. These factors result in dry and thin skin, flattening skin, wrinkles, rough texture, and facial sagging [1]. The human desire to look young daily makes addressing these skin issue

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Aubry, Selene, Pierre-Yves Collart-Dutilleul, Matthieu Renaud, et al. "Benefit of Hyaluronic Acid to Treat Facial Aging in Completely Edentulous Patients." Journal of Clinical Medicine 11, no. 19 (2022): 5874. http://dx.doi.org/10.3390/jcm11195874.

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Hyaluronic acid (HA) is widely used in aesthetic medicine for its moisturizing and anti-aging action. This molecule, which is naturally present in the body, has an interesting response to aging, accentuated in totally edentulous patients. While its aesthetic benefits for facial rejuvenation are well-documented, there is a lack of description and investigation on its therapeutic usefulness for edentulous patients. The management of completely edentulous patients is a daily reality in dental practice and requires specific attention. The aesthetic and functional challenge is considerable. The dis

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Miller, Amy. "Using ultrasound to evaluate facial fillers and other commonly encountered aesthetic skin issues." Journal of Aesthetic Nursing 11, no. 7 (2022): 286–91. http://dx.doi.org/10.12968/joan.2022.11.7.286.

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Handheld high-frequency ultrasound is a helpful tool for an aesthetic injector, and its use is becoming more common in aesthetic practices. Ultrasound can be used to guide dermal filler injections and avoid complications. With ultrasound, the practitioner can garner clues to identify the type and age of previously injected fillers. It can help determine the best depth or plane of injections, as well as monitor the efficacy of aesthetic treatments other than injections and monitor the progression of certain dermatologic diseases. The aesthetic practitioner should seriously consider adding ultra

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Lighthall, Jessyka. "Rejuvenation of the Upper Face and Brow: Neuromodulators and Fillers." Facial Plastic Surgery 34, no. 02 (2018): 119–27. http://dx.doi.org/10.1055/s-0038-1637004.

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AbstractFacial aging involves a combination of volume loss and descent, loss of skin elasticity, dynamic lines due to facial mimetic muscle action, and development of static rhytids. Although surgery remains an option for treatment, minimally invasive aesthetic procedures continue to gain popularity with the use of neuromodulators and soft tissue fillers being the most sought-after procedures. Although these may be used in isolation to treat specific concerns, they are often combined to address multiple facets of aging. Multiple different neuromodulators and fillers are commercially available.

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Musolff, Noah, Carmen Cantisani, Stefania Guida, et al. "Different Pathways of Skin Aging: Objective Instrumental Evaluation." Diagnostics 14, no. 21 (2024): 2381. http://dx.doi.org/10.3390/diagnostics14212381.

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Background/Objectives: Hypertrophic and atrophic skin aging represent two distinct phenotypes: hypertrophic aging is marked by deep wrinkles and a leathery texture, whereas atrophic aging is characterized by overall skin thinning, increased vascularity, and a higher risk of non-melanoma skin cancers. This study aims to elucidate the characteristics and differences between hypertrophic and atrophic facial aging subtypes using two non-invasive imaging devices: VISIA® and dynamic optical coherence tomography (D-OCT). Methods: We retrospectively evaluated patients who had presented to the outpatie

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Guo, Fengfeng, Yuxi Xia, Qingqian Wei, Jun Zhuang, Jinge Li, and Jintian Hu. "Treatment of Facial Artery Embolization Caused by Polycaprolactone-based Dermal Filler with a Regimen Including 5-Fluorouracil." Plastic and Reconstructive Surgery - Global Open 12, no. 9 (2024): e6140. http://dx.doi.org/10.1097/gox.0000000000006140.

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Summary: Polycaprolactone-based fillers are commonly used in plastic surgery to improve facial aging. However, adverse vascular events following these injections have been reported. An arterial embolism is a rare but serious complication associated with injectable filler procedures. We report a case of arterial embolism in a 35-year-old woman who received a polycaprolactone-based dermal filler at the nasal base and was treated with a regimen containing 5-fluorouracil. We discuss the potential causes of the patient’s condition and assess the superiority of our method over conventional approache

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Lee, An-Li, Yu-Fan Chen, Wen-Teng Yao, et al. "Laser Doppler Imaging for Treating Vascular Complications from Procedures Involving Dermal Fillers: Case Series and Literature Review." Diagnostics 11, no. 9 (2021): 1640. http://dx.doi.org/10.3390/diagnostics11091640.

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Vascular occlusion is a rare but severe complication of dermal filler injections. Early treatment of this complication produces better outcomes. Current diagnostic methods for vascular occlusion in the skin are subjective and imprecise; these include capillary refill time, skin color, and reports of pain. This study aimed to assess the use of laser Doppler imaging (LDI) in the evaluation and treatment of vascular complications caused by dermal filler injections. This retrospective study used laser Doppler imaging (LDI) in 13 patients who developed vascular occlusion after facial dermal filler

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Li, Qing, Yiling Zhang, Jingbing Li, et al. "Stimulatory effects of poly-para-dioxanone, poly L-lactic acid, polycaprolactone, and poly(lactic-co-glycolic acid)/PLLA in rats." Materials Express 9, no. 8 (2019): 962–69. http://dx.doi.org/10.1166/mex.2019.1582.

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Numerous fillers are increasingly used for augmenting volume loss and ameliorating facial wrinkles. Collagen stimulants are the most recent next-generation dermal fillers capable of inducing neocollagenesis. To investigate biophysical characteristics, the safety and efficacy of the newly developed combination, poly(L-lactide) or polyl-lactic acid (PLLA) and poly(lactide-co-glycolide) (PLGA), were compared with those of poly-para-dioxanone (PPDO), poly-l-lactic acid (PLLA), and polycaprolactone (PCL) fillers. PPDO, PLLA, PCL, or PLGA/PLLA was injected into the dorsal skin of 8-week-old rats. Ti

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Lee, Hyejin, Sanghyun Ye, Juhyun Kim, Seung-Hyun Jun, and Nae-Gyu Kang. "Improvement in Facial Wrinkles Using Materials Enhancing PPARGC1B Expression Related to Mitochondrial Function." Current Issues in Molecular Biology 46, no. 6 (2024): 5037–51. http://dx.doi.org/10.3390/cimb46060302.

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Skin aging is an unavoidable natural phenomenon caused by intrinsic and extrinsic factors. In modern society, the pursuit of a wrinkle-free and aesthetically appealing face has gained considerable prominence. Numerous studies have aimed at mitigating the appearance of facial wrinkles. Antiaging research focused on regulating the function of mitochondria, the main reactive oxygen species-generating organelles, has been extensively conducted. In this study, we investigated the correlation between facial wrinkles and the expression of PPARGC1B, considering the association of this gene with mitoch

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Puljic, Anto, Konstantin Frank, Joel Cohen, et al. "A Scientific Framework for Comparing Hyaluronic Acid Filler Crosslinking Technologies." Gels 11, no. 7 (2025): 487. https://doi.org/10.3390/gels11070487.

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Hyaluronic acid (HA) dermal fillers represent a cornerstone of modern esthetic medicine, providing a minimally invasive solution for facial volume restoration and skin rejuvenation. However, the diversity of available products, each utilizing distinct crosslinking technologies, presents a challenge for objective comparison and clinical decision making. This study introduces a scientific framework to evaluate and categorize the physicochemical properties of HA fillers based on two key parameter groups: dynamic parameters (e.g., rheology and gel content) and consistency parameters (e.g., extrusi

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Saad, sami AlSogair. "Rheology of Hyaluronic Acid Dermal Fillers: Understanding the Science to Improve Results in Clinical Practice." International Journal Of Health & Medical Research 02, no. 05 (2023): 96–103. https://doi.org/10.5281/zenodo.7924453.

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Hyaluronic acid fillers are one of the most frequently used in cosmetic procedures. They are popular because of their ability to restore volume to the face, which surgery isn’t capable of. Inside the skin, the implant is subjected to various mechanical forces that vary according to the anatomical area. Every filler has specific rheological properties which change the way it performs in the clinical environment. A sound understanding of how the anatomy of the face works, alongside the rheological properties of the filler, is vital for successful outcomes in facial rejuvenation procedures.

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Zeltzer, Assaf, Aviad Keren, Ralf Paus, and Amos Gilhar. "Preclinical Evidence That Mesoglycan Unfolds Complex Anti-Aging Effects in Photoaged Female Facial Skin." International Journal of Molecular Sciences 26, no. 12 (2025): 5787. https://doi.org/10.3390/ijms26125787.

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Novel senotherapeutics are needed to reverse aging-related skin decline. The research question addressed was whether mesoglycan, a clinically approved glycosaminoglycan formulation known to enhance perfusion, angiogenesis, and VEGF-A signaling, possesses therapeutic potential for rejuvenating photo aged human skin. To test this, we treated full-thickness photoaged facial human skin samples (mean age: 72 ± 5 years) from seven women ex vivo. The samples were treated with topical or medium-delivered mesoglycan (100, 200, and 300 µM) for 6 days under serum-free conditions that accelerate skin agin

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