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Journal articles on the topic 'Dermatological forms'
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Znagovan, Alexandru, Vladislav Gogu, Margarita Fetman, and Tatiana Caisim. "Modern industrial pharmaceutical forms used in dermatological practice in the Republic of Moldova." Moldovan Medical Journal 63(6) (December 1, 2020): 16–20. https://doi.org/10.5281/zenodo.4028367.
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<strong>Background:</strong> Fighting skin diseases is a strict medical, as well as socio-economic issue for the Republic of Moldova, since they may have an aesthetic and psychological impact. The author of this scientific article presented an analysis of the pharmaceutical preparations and their forms used in the treatment of dermatological diseases based on those recorded in the State Nomenclature of the Republic of Moldova according to Anatomical Therapeutic Chemical classification, dose, division, manufacturing country and industrial pharmaceutical company, producer price, and terms of validity. <strong>Material and methods: </strong>This research paper is based on the literature and 400 clinical documents, State Nomenclature of the Republic of Moldova, the result analysis of dermatological drug manufacturers and producers, the shelf life declared by the manufacturer, etc. <strong>Results: </strong>From a total of 10924 preparations registered in the Republic of Moldova on 14.04.2017 – 526 were preparations used in dermatological practice. The top of pharmaceutical forms used in dermatological practice and registered in the Republic of Moldova were the ointments – 274 (52.09%) and solutions for external use – 162 (30.80%). Of the 27 producing countries, the most pharmaceutical preparations, registered in the Republic of Moldova, 212 preparations (40.30%) were of domestic origin, which also had the lowest price. The leader was Farmaprim SRL with 46 registered preparations. The shelf life of most dermatological preparations – 505 (96%), registered in the Republic of Moldova was at least 24 months – a parameter-guarantor of quality. <strong>Conclusions: </strong>The share of preparations used in dermatological practice in the Republic of Moldova was 4.82%, of which pharmaceutical external forms accounted for over 80%. Most preparations registered and used in the dermatological practice in the Republic of Moldova were of local origin, which are qualitative, as well as the most accessible.
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Abeyrathna, Parami, Tharindu Nadeesha, Nuwani Malika, Nawoda Wijerathna, and Suneth Agampodi. "Common dermatological complaints and their psychosocial impact: a descriptive cross-sectional study among undergraduates of an outstation university of Sri Lanka." Anuradhapura Medical Journal 17, no. 2 (2023): 20–24. http://dx.doi.org/10.4038/amj.v17i2.7730.
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Introduction: Dermatological conditions are non-life-threatening but cause serious psychological stress among the young population. This study was conducted to determine the prevalence of selected self-reported dermatological conditions and their impact on university students.Methods: A descriptive cross-sectional study was conducted in three faculties of the Rajarata University of Sri Lanka. A minimum of 200 undergraduates were selected from each faculty from simple random sampling. A validated, self-administered questionnaire was used in Sinhala English and Tamil all as e-forms and papers to assess the common dermatological complaints, duration, and associated psycho-social effects.Results: Among 614 participants, 400 (65%) females and 214 (35%) males were included. More than half of the participants (n=326, 53%) reported a dermatological complaint during their university period and 277 reported a recurrent dermatological problem. Self-reported acne was the most reported (n=325) and diagnosed psoriasis (n=2) was the least reported condition of interest. Pityriasis versicolar prevalence was significantly highest among males (n=257) and dandruff was commonest among females (n=178).The study has shown significant self-reported distress associated with dermatological conditions which make 89.7% of participants think dermatological conditions as something to worry about, p<0.005. Common responses for dermatological conditions were self- medication (n=200, 32.5%) and consultation of any doctor (n=342, 55%)Conclusion: Higher prevalence of dermatological conditions among university students should be addressed during health interventions. Psycho-social effects which can lead to personal and academic distress need to be intervened carefully to improve the quality of life
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Bambauer, Rolf, Daniel Burgard, and Ralf Schiel. "Therapeutic Apheresis in Dermatological Diseases." Clinical Medicine Insights: Therapeutics 7 (January 2015): CMT.S14112. http://dx.doi.org/10.4137/cmt.s14112.
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Since the mid-1970s, membrane modules became available and plasma separation techniques have gained importance. Therapeutic apheresis (TA) has been successfully introduced in a variety of autoantibody-mediated diseases. In dermatology, TA is increasingly applied as a support treatment for severe and/or refractory autoimmune bullous diseases. All autoimmune disease are characterized by autoantibodies mediated against structural proteins of the skin and/or mucous membranes. Autoimmune blistering diseases have a high morbidity and mortality. These diseases include pemphigus vulgaris and bullous pemphigoid among others. Drug-induced pemphigus and other forms, such as dermatitis herpetiformis, herpes gestationis, scleroderma, pyoderma gangrenosum, epidermal necrolysis, Behcet disease, psoriasis vulgaris, Henoch-Schönlein purpura, and porphyria cutanea tarda, are also mentioned. Pathogenetical aspects of autoantibodies in these diseases are clearly demonstrated. TA has been shown to effectively remove the autoantibodies from blood and lead to rapid clinical improvement.
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ARAVIJSKAYA, E. R., E. V. SOKOLOVSKY, S. M. BAKHTINA, and M. V. PCHELINTSEV. "Role of vehicle in topical steroids: optimal composition and mode of action." Vestnik dermatologii i venerologii 86, no. 2 (2010): 64–70. http://dx.doi.org/10.25208/vdv930.
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Shah, Vinod P., Gordon L. Flynn, Avraham Yacobi, et al. "Bioequivalence of Topical Dermatological Dosage Forms – Methods of Evaluation of Bioequivalence." Skin Pharmacology and Physiology 11, no. 2 (1998): 117–24. http://dx.doi.org/10.1159/000029817.
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Shunmugavelu, Karthik, Ajitha Rajalingam, and Shilpa Dandekeri. "Cutaneous foci of infection obliterating head and neck region - An original research." Romanian Journal of Infectious Diseases 28, no. 1 (2025): 11–15. https://doi.org/10.37897/rjid.2025.1.2.
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Background. Systemic diseases can manifest in the oral cavity in various forms, and dermatological conditions often present with oral mucosal lesions. These lesions may be the initial indication of an underlying dermatological disease or the only clinical manifestation. Early recognition of such signs is crucial for accurate diagnosis and timely management. Materials and methods. This study included 1,131 patients who visited a dermatology institute for various skin conditions. Demographic details were recorded, and a thorough dermatological and oral examination was conducted. The location and size of oral lesions were documented. Descriptive statistics were computed using SPSS version 21, with a significance level set at P < 0.05. Patients received health education and information regarding their oral health status. Results. The majority of affected individuals were between 25–50 years old (76%). No gender predilection was observed, with male (49.7%) and female (50.3%) patients being equally affected. Of the 1,131 patients, 237 (20.9%) had oral mucosal lesions associated with dermatological conditions. Among the dermatological cases diagnosed, 12 distinct conditions presented with oral manifestations. The palate was the most commonly affected oral site (38.3%). Psoriasis (44.3%) was the most frequent dermatological condition with oral involvement, followed by pemphigus (31.2%) and bullous pemphigoid (10.1%). Conclusion. Oral mucosal lesions play a significant role in the early diagnosis of dermatological diseases. A multidisciplinary approach involving dermatologists and dentists is essential for timely detection and effective management of these conditions.
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Farhadian, Sadegh, Behzad Shareghi, Ali A. Saboury та Lida Momeni. "Counteraction of lactose on the thermal stability and activity of α-chymotrypsin: thermodynamic, kinetic and docking studies". RSC Advances 6, № 76 (2016): 72201–12. http://dx.doi.org/10.1039/c6ra11833j.
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Stabilized aqueous solutions of α-chymotrypsin have a therapeutic utility in the treatment of certain forms of asthma, bronchitis, rhinitis, sinusitis, as well as certain dermatological conditions such as leg ulcers and ringworm.
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Ferrari, Flavio Leme, Marcos Leal Brioschi, Carlos Dalmaso Neto, and Carlos Roberto de Medeiros. "Infrared Macrothermoscopy Patterns—A New Category of Dermoscopy." Journal of Imaging 9, no. 2 (2023): 36. http://dx.doi.org/10.3390/jimaging9020036.
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(1) Background: The authors developed a new non-invasive dermatological infrared macroimaging analysis technique (MacroIR) that evaluates microvascular, inflammatory, and metabolic changes that may be dermoscopy complimentary, by analyzing different skin and mucosal lesions in a combined way—naked eye, polarized light dermatoscopy (PLD), and MacroIR—and comparing results; (2) Methods: ten cases were evaluated using a smartphone coupled with a dermatoscope and a macro lens integrated far-infrared transducer into specific software to capture and organize high-resolution images in different electromagnetic spectra, and then analyzed by a dermatologist; (3) Results: It was possible to identify and compare structures found in two dermoscopic forms. Visual anatomical changes were correlated with MacroIR and aided skin surface dermatological analysis, presenting studied area microvascular, inflammatory, and metabolic data. All MacroIR images correlated with PLD, naked eye examination, and histopathological findings; (4) Conclusion: MacroIR and clinic dermatologist concordance rates were comparable for all dermatological conditions in this study. MacroIR imaging is a promising method that can improve dermatological diseases diagnosis. The observations are preliminary and require further evaluation in larger studies.
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Zaliska, Olha, and Zoryana Zabolotnya. "Analysis of extemporal prescription state for dermatological diseases and problem aspects during marital state in Ukraine." Annals of Mechnikov Institute, no. 1 (March 12, 2025): 46–49. https://doi.org/10.5281/zenodo.15011703.
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<strong>Introduction.</strong> The negative trend of the reduction of pharmacies with the manufacture of medicinal forms in the Western region for the years 2014-2024 during the war was investigated and the need to preserve and expand the number of pharmacies that prepare extemporaneous medicines, which is relevant in the conditions of martial law, was substantiated. The purpose of this work was to analyze the dynamics of the number of pharmacies that extemporaneously manufacture medicines over the last 10 years during the war in the Western region in order to determine trends. Our task was to study the list of medicinal forms that are actually produced in pharmacies, especially for dermatological diseases. The objects of analysis were documents, orders for pharmacies with compounding departments during last 10 years. The nomenclature of pharmaceuticals from 14 pharmacies that have valid licenses and actually carry out extemporaneous production of drugs in the city of Lviv and the Lviv region was studied. Research methods: historical, bibliographic, documentary, content analysis, systematization and generalization. We have selected a set of 12 dosage forms that were most often produced during the period of martial law during 2022-2024, these prescriptions can be recommended for implementation in the work of production departments of private pharmacies. It was substantiated that the urgent task of harmonizing with EU legislation regarding the work of pharmacies that have extemporaneous production is the need to make changes to the Licensing Conditions of Pharmacies on the mandatory extemporaneous production of medicinal forms in each pharmacy, regardless of the form of ownership.
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Zuykina, Yelyzaveta, Svitlana Zuykina, Marina Buryak, Liliia Vyshnevska, and Svitlana Oleynik. "Research on the development of the composition extemporaneous medicine with dexpanthenol." Annals of Mechnikov Institute, no. 1 (March 19, 2024): 39–45. https://doi.org/10.5281/zenodo.10838552.
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The prevalence of dermatological diseases is one of the problems of medical practice. Against the background of chronic stress disorders during the war, the incidence of contact dermatitis, atopic dermatitis, eczema, fungal lesions, psoriasis and other diseases has been increased. On the pharmaceutical market of Ukraine, soft dosage forms occupy approximately 10% among other drugs of industrial production. A large share also belongs to soft medicinal forms of extemporaneous production in Ukraine and abroad. The choice of the basis is depend on the physical and chemical properties of the active pharmaceutical ingredient, the pathological process, the method of application and the predicted pharmacological effect. One of the perspective directions of expansion and renewal of the prescription of extemporaneous medicine is the development of soft medicines on emulsion bases. The evolution of atopic dermatitis is a multifactorial process involving immunological defects, skin barrier dysfunction, genetic variation, and environmental factors. Dexpanthenol provides a noticeable moisturizing effect, due to its extremely hygroscopic characteristics, Topical application of dexpanthenol improves skin hydration and reduces trans-epidermal water loss, thus maintaining skin smoothness and elasticity. According to the assessment of average moisture retention for 5 hours, dexpanthenol provides a long-lasting effect of moisturizing tissues <strong>Aim. </strong>The aim of the work was development of emulsion-base of soft medicinal form for the treatment of atopic dermatitis with dexpanthanol and conducting comparative studies of the effectiveness of the drug. <strong>Materials and methods. </strong>Information-searching, information-analytical, marketing, organoleptic, physico-chemical, pharmacotechnological methods of research are used in the work. Research objects:<strong> </strong>dexpanthenol was used as active pharmaceutical ingredients, corn oil, cetyl stearyl alcohol, sorbitan oleate (Span 80), sorbitan stearas (Sorbitani stearas, Span 60), purified water, vaseline, anhydrous lanolin as auxiliary substances. <strong>Results and discussion. </strong>At the first stage of research, a review of existing emulsifiers found in the prescriptions of national and foreign dermatological drugs was conducted. The analysis of emulsifiers was carried out according to the following characteristics: international name, UNII (Unique Ingredient Identifier) code, unique identifier of the ingredient, aggregate state, value of HLB (hydrophilic-lipophilic balance), list of world pharmacopoeias in which this emulsifier is described, maximum effective content in the recipe. Among all emulsifiers, our attention was drawn to sorbitan monooleate (Span 80) - with a HLB value is 4.3 and sorbitan monostearate (Span 60), whose HLB is 4.7. The concentration of emulsifiers was chosen as the average recommended according to the results of previous scientific studies. The presence and concentration of cetylstearyl alcohol in the samples was varied in order to increase stability. Based on the above information, dexpanthenol in the form of an aqueous solution with a concentration of 30% was chosen as an active pharmaceutical ingredient in the development of the ointment. This solution is 5% of the total weight of the soft dosage form, which is 17 g per mass unit. The samples had different consistent properties, passed the test for thermal and colloidal stability. According to the results of the study of the structural and mechanical properties of the experimental samples, rheograms of the dependence of the shear stress (Dr) on the shear rate (t) at a temperature of 20 ºС and a graph of the dependence of viscosity on the shear rate were constructed. <strong>Conclusions. </strong>According to the results of the informational and analytical analysis, it was established that currently extemporaneous production needs updating and improving the prescription of soft medicinal forms. A study was conducted on the selection of auxiliary substances and their concentration. It was determined that emulsifiers with a HLB value of 4–6 are optimal for creating inverse emulsions (w/o). Based on the results of rheological and organoleptic (sensory) studies, the composition of extemporaneous soft medicinal forms on an emulsion basis for the treatment of dermatological diseases is proposed.
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Pelloni, Lorenzo, Simone Cazzaniga, Luigi Naldi, Luca Borradori, and Carlo Mainetti. "Emergency Consultations in Dermatology in a Secondary Referral Hospital in Southern Switzerland: A Prospective Cross-Sectional Analysis." Dermatology 235, no. 3 (2019): 243–49. http://dx.doi.org/10.1159/000498850.
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Background/Aims: The spectrum of dermatological emergencies is broad. Only a few studies have assessed the profile of dermatological conditions resulting in an emergency visit in a referral hospital. We sought to assess the conditions prompting an urgent dermatological visit and to compare the diagnoses with those made during the regular scheduled encounters. Methods: We performed a cross-sectional study of all patients with a cutaneous problem attending our emergency consultation during a 7-month period. The study variables were gender, age, duration of symptoms, diagnosis, need for hospitalization and/or follow-up. We further evaluated patients attending scheduled visits to compare the demographic characteristics and diagnoses between the two groups. Results: Six hundred fifty-two consecutive patients with an urgent dermatological consultation were included. Three hundred sixty (55.2%) were women and 292 (44.8%) were men. Infectious diseases (32.8%) as well as various forms of eczema (24.8%) constituted the most frequent causes for an emergency visit. Approximately 40% of emergency visits took place more than 1 week after the development of the cutaneous manifestations. The most frequent disorders seen in the 1,738 control patients included benign melanocytic and nonmelanocytic tumors (27.2%) and malignant skin lesions (11.5%). Conclusions: Our study indicates that the dermatological diagnoses in the emergency visits significantly differ from those of the routinely scheduled appointments. In a significant portion of patients, the use of an emergency consultation was not justified. This study provides support to the idea that a specific training is required to manage dermatological emergencies and that efforts should be made to reduce unjustified emergency visit use.
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Mohammed, Essameldeen M., Waleed A. Mahmoud, and Sara Q. A. Rahim. "Assessment of dermatological quality of life index in patients attending to laser unit." Al-Azhar Assiut Medical Journal 23, no. 1 (2025): 39–45. https://doi.org/10.4103/azmj.azmj_57_24.
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Background and aim Many dermatological diseases have an impact on daily life activity. Dermatology life quality index (DLQI), is a self-administered general dermatology quality of life (QoL) instrument. It is an easy and efficient tool for assessing the QoL in dermatology patients. We aimed to assess the psychological and social impact of chronic dermatological diseases on patients attending the laser unit by using the DLQI questionnaire. Patients and methods This is a cross-sectional study that was conducted on 300 patients showing various clinical forms of dermatological disorders. They were selected from patients who attended the laser unit of the Dermatology and Andrology Department of Al-Azhar University Hospital (Assuit). Results The total mean DLQI was 10.42. Skin disorders presented with poor QoL and high DLQI score were, hirsutism, melasma, acne, rosacea, postburn scar, nevus of otta, Becker’s nevus, and Port wine stain, with mean DLQI score of 16.77, 14.71, 13.63, 12.36, 12.34, 11.55, 11.25, and 10.0, respectively. However, skin disorders presented with mild or moderate DLQI scores were freckles, tattoo, keloid, stria rubra, and hypertrichosis, with mean DLQI scores of 6.16, 6.27, 7.80, 8.20, and 8.47, respectively. Conclusion Most dermatological diseases can affect QoL. DLQI is a valuable tool for the assessment of the impact of different skin disorders on QoL.
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Elpern, David, and Henry Foong. "Health Professional ‘Web Based Conversational Learning’ on Unusual Forms of Lupus." International Journal of User-Driven Healthcare 1, no. 3 (2011): 1–6. http://dx.doi.org/10.4018/ijudh.2011070101.
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This article illustrates a web-based conversational learning system termed, “Virtual Grand Rounds in Dermatology” (VGRD), that was developed by two dermatologist colleagues from the United States and Malaysia, respectively, over the past decade. Two blog posts discussing the diagnostic uncertainty around possible dermatological manifestations of lupus are highlighted along with a few conversational comments from other health professionals. The posts, as they appear on VGRD are presented verbatim and illustrate a health professional narrated website that relies heavily on images and pattern recognition. We show that health professional learning may thrive on feedback from colleagues, even if minimal.
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Archana, S., and N. Shyamsundar. "Computational Intelligence for Detection of Skin Cancer using Deep Learning Classifiers." International Innovative Research Journal of Engineering and Technology 7, no. 1 (2021): 10–18. http://dx.doi.org/10.32595/iirjet.org/v7i1.2021.149.
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Artificial intelligence (AI) has been recognized as an important research field in computer science. Although AI has been around for a while and has been used in many disciplines of medicine, its usage in dermatology is very recent and constrained. Dermatology is a field of bioscience concerned with the diagnosis and treatment of skin diseases. The wide range of dermatologic diseases changes regionally and seasonally according to temperature, humidity, and other environmental factors. Dermatological illnesses have been shown to have major impacts on the behavior of millions of individuals since nearly all forms of skin problems affect everyone every year. Because human analysis of such diseases requires time and effort, and existing techniques are only utilized to analyze certain types of skin diseases, there is a need for higher-level computer-aided skills in the analysis and diagnosis of multi-type skin disorders.
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Khardikova, S. A. "Efficacy and tolerability of various forms of Akriderm GK in routine dermatological practice." Klinicheskaya dermatologiya i venerologiya 15, no. 5 (2016): 55. http://dx.doi.org/10.17116/klinderma201615555-61.
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Gupta, Mrinal, Vikram K. Mahajan, Karaninder S. Mehta, and Pushpinder S. Chauhan. "Zinc Therapy in Dermatology: A Review." Dermatology Research and Practice 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/709152.
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Zinc, both in elemental or in its salt forms, has been used as a therapeutic modality for centuries. Topical preparations like zinc oxide, calamine, or zinc pyrithione have been in use as photoprotecting, soothing agents or as active ingredient of antidandruff shampoos. Its use has expanded manifold over the years for a number of dermatological conditions including infections (leishmaniasis, warts), inflammatory dermatoses (acne vulgaris, rosacea), pigmentary disorders (melasma), and neoplasias (basal cell carcinoma). Although the role of oral zinc is well-established in human zinc deficiency syndromes including acrodermatitis enteropathica, it is only in recent years that importance of zinc as a micronutrient essential for infant growth and development has been recognized. The paper reviews various dermatological uses of zinc.
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Negreanu-Pîrjol, Ticuţa, Bogdan-Ştefan Negreanu-Pîrjol, and Dan Razvan Popoviciu. "Preliminary Data Regarding Pharmaceutical Forms Type Gels Based on Marine Algae Extracts with Antioxidant Activity." European Journal of Medicine and Natural Sciences 4, no. 2 (2021): 26. http://dx.doi.org/10.26417/859cnk51g.
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Particularly interest on herbs and plant extracts is due to their content of active principles with remarkable pharmacological properties. Different vegetal species contain natural antioxidants (polyphenols) used for their dermatological anti-inflammatory and healing activity, justified by their action on free radicals. The aim of this paper was to obtain selected phytopharmaceuticals formulations type gels with an increased antioxidant potential based on a mixture of fluid extracts from seaweeds species in the phylum Chlorophyta, Cladophora vagabunda (L.) C. Hoek, in the family Cladophoraceae, Ulva lactuca (L.) syn. Ulva rigida (L.), in the family Ulvaceae (sea lettuce) and species in the phylum Rhodophyta, Ceramium rubrum C. Agardh, in the famiy Ceramiaceae, frequently presents along the Romanian Black Sea coast. Fluid extracts concentration 10 percent were obtained using cold maceration extraction method, in solvents ethylic alcohol 40 percent and 70 percent. The obtained vegetal extracts were mixed in different ratio and analysed for physico-chemical properties, for the content of total phenols, chlorophylls, cartenoids, flavonoids and antioxidative capacity by photochemiluminescence method (ACL, Analytik Jena AG procedure). The selected mixed fluid extracts with greatest content of polyphenols and antioxidant activity were used for obtaining pharmaceutical forms type gels which were analyzed for the physical-chemical properties appearance, pH, spredability and total antioxidative capacity. Preliminary results emphasized that proposed pharmaceutical forms type gels had an appreciable antioxidant activity correlated with a good stability, an increased polyphenols content and would represent a possible new dermatological anti-inflammatory and healing preparation.
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Aksenenko, Maria B., and T. G. Ruksha. "Sequencing methods in dermatology." Russian Journal of Skin and Venereal Diseases 19, no. 1 (2016): 7–12. http://dx.doi.org/10.18821/1560-9588-2016-19-1-7-12.
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Review of the literature devoted to the application of sequencing methods (genome research method) at various dermatological diseases. DNA sequencing technology is described in the article. Sanger Sequencing Method and Next-Generation Sequencing are discussed. Examples of genes and mutations found by sequencing methods are presented. Clinical meaning of mutations in BRAF, NRAS, KIT, GNAQ, GNA11 genes that play an important role in the pathogenesis of different clinical pathological forms of melanoma is described. Reveling tumor subtypes provides a selective approach in treatment of cutaneous melanoma, that can be useful in different therapeutic methods and makes it possible to predict the development of chemoresistance. Furthermore, data about another genes, that play an important role in pathogenesis of different dermatological diseases with tumor and non-tumor genesis are presented.
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Dugonik, Bogdan, and Marjan Golob. "Exploring the Impact of Imaging Resolution and Sharpness on Dermatological Diagnostics Using eSFR Measurements." Elektronika ir Elektrotechnika 31, no. 1 (2025): 47–55. https://doi.org/10.5755/j02.eie.40333.
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High-resolution, small-form-factor image sensors enable the integration of mobile device cameras, which are increasingly being used for photographic documentation in many fields, including medicine. With the interface and handheld dermatoscopy, the smartphone camera forms an alternative tool to professional dermatoscopic systems for performing teledermatology and teledermoscopy. For the accurate diagnosis of skin diseases, image quality is essential, with sharpness and resolution being essential criteria. This paper focusses on measuring the sharpness and resolution of cameras used for image acquisition in dermatology using the spatial frequency response (SFR) method, which is based on standardised test charts featuring characteristic slanted contrast edges, known as edge SFR (eSFR) charts. The images were captured with mirrorless and DSLR cameras, smartphones, and a professional dermatoscopy video camera under typical dermatological conditions with digital cameras, mobile phones, and professional video dermatoscopes. Captured images were analysed, and the modulation transfer function (MTF) was defined to evaluate the performance of different camera optical systems applied for dermatological imaging. The results provide insight into the strengths and limitations of the various imaging devices and highlight their effectiveness in meeting the requirements of dermatological practice.
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SD, Asha, and Jayanthi P. "Management of Oral Lichen Planus: Recent updates." International Journal of Contemporary Dental Research 1, no. 2 (2023): 27–30. http://dx.doi.org/10.62175/apdch2311.
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Oral lichen planus is one of the most common dermatological disease affecting the oral mucosa. It is characterized by periods of remission and exacerbation. Regular follow up is needed for some severe forms of oral lichen planus. Various treatment modalities are reported in the literature and this article discusses about some of the recent medications used in patients with oral lichen planus.
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Zhadan, Irina Yu, Irina V. Yatsyna, Evgeniya K. Krasavina, and Yaroslav V. Beshlyy. "The influence of harmful environmental factors on the dermatological health of the population." HEALTH CARE OF THE RUSSIAN FEDERATION 65, no. 4 (2021): 342–46. http://dx.doi.org/10.47470/0044-197x-2021-65-4-342-346.
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Introduction. A significant level of dermatological morbidity requires consideration of the influence of external environmental factors on the development and progression of skin pathology. Purpose: to assess the structure of dermatological morbidity of the population exposed to harmful environmental factors, with the definition of priority for the children’s population. Objectives were to assess the structure of dermatological morbidity of the population exposed to harmful environmental factors, with the priority for the children’s population of the Mytishchi district of the Moscow Region. Material and methods: statistical data on the morbidity of the children’s population of the Mytishchi district of the Moscow Region and the dermatological department of the Institute of General and Occupational Pathology of the Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Human Wellbeing. Data on pollution by harmful environmental factors of the district, social and hygienic monitoring data in the Mytishchi district on pollution by harmful environmental factors, using mathematical statistics methods (correlation dependence, Student’s coefficient). Results. Residents of the Mytishchi district are exposed to adverse environmental factors, the children’s population is most susceptible to their influence. The greatest influence belongs to the pollution of atmospheric air and water. The most common skin pathology in children includes atopic dermatitis and eczema. Statistics of inpatient dermatological care for 2017-2019 in the profile department of the Institute of General and Occupational Pathology of the F.F. Erisman data indicate a similar distribution of skin pathology in the adult population. Conclusions. The obtained data require in-depth preventive examinations in organized children’s groups at regional enterprises to detect early forms of diseases and comprehensive hygienic preventive measures to improve the state of the environment in the Mytishchi district of the Moscow Region.
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Plotnikova, Inga Albertovna, Vera Leonidovna Zelentsova, Irina Gennadiyevna Lavrik, Arseniy Alekseevich Egorov, and Svetlana Andreevna Nakhratova. "Features of clinical course and skin lesions associated with new coronavirus infection in children." Allergology and Immunology in Pediatrics, no. 1 (March 21, 2022): 27–33. http://dx.doi.org/10.53529/2500-1175-2022-1-27-33.
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Annotation. This article discusses the features of skin lesions and the clinical course of a new coronavirus infection in children. Among the extrapulmonary signs associated with COVID-19, dermatologic manifestations have increasingly appeared in the past few months. The aim of the study was to correlate available data in the literature on variants of dermatological manifestations of COVID-19 in children with clinical examples of skin lesions associated with this infection in patients seen by a specialized dermatologist. We used PubMed and Cyberleninka search engines for the period 2020–2021 Systematized variants of dermatological syndromes in children who had undergone COVID-19 described in reviews of materials by domestic and foreign researchers. The authors analyzed the primary medical records and photographic archives of children admitted to the outpatient clinic of a dermatologist at Yekaterinburg municipal clinical hospital No. 9 for 1 month after the established family contact with a new case of coronavirus infection. Analysis of scientific literature data showed that SARS-CoV-2 virus-associated skin lesions in children were more frequent in the mild course of infection, presumably with the implementation of an immunocomplex mechanism of vascular and epithelial damage. The pronounced vascular damage is a distinctive feature of COVID-19-related exanthemas, especially when localized on the fingers of the lower extremities. This article presents 5 clinical cases of children with various forms of acute dermatoses: urticaria, frostbite-like exanthema of the fingers, onychodystrophy, alopecia, and generalized pustular psoriasis of Zumbush. Only three children had laboratory confirmation of SARS-CoV-2 infection.
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Snarskaya, E. S. "Antibacterial therapy of vulgar acne." Vestnik dermatologii i venerologii 95, no. 5 (2019): 58–67. http://dx.doi.org/10.25208/0042-4609-2019-95-5-58-67.
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Purpose: to evaluate the efficacy and safety of minocycline in the therapy of medium-heavy and severe forms of acne vulgaris according to modern ideas about pathogenesis of the disease.Materials and methods. Long-term multi-purpose observation which included 28 patients with the established diagnosis of acne vulgaris, medium-weight and severe forms is made. Patients received monotherapy by Minoleksin® medicine, depending on severity — 50–100 mg a day. Prior to the research and after the end of treatment inspection of the patient with calculation the rash elements, clinical and biochemical blood analysis, a research of function of sebaceous glands, the laser scanning microscopy, a laser Doppler floumetry, definition of the dermatological index of quality of life, photography (was performed at the consent of the patient). In the course of therapy inspection of the patient and assessment of tolerance of drug was performed.Results. The evidence of efficiency of minocycline in treatment of vulgar acnes of average and heavy severity is obtained that is confirmed by visual dermatological indicators, non-invasive methods of a research (results of a sebumetriya, the confocal laser scanning microscopy, a Doppler floumetriya), indicators of the dermatological index of quality of life. When studying clinical and laboratory indicators security concerns are not revealed. The undesirable phenomena in the course of the research are not registered.Conclusion. Minolexin® (minocycline) is highly effective and safe drug for treatment of vulgar acnes of average and heavy severity and it can be recommended for practical application in out-patient practice.Conflict of interest: the author states that there is no potential conflict of interest requiring disclosure in this article.
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Baltabaev, A. M., V. P. Tkachev, and M. K. Baltabaev. "Differential diagnostic criteria of alopecia areata." Russian Journal of Skin and Venereal Diseases 19, no. 6 (2016): 359–64. http://dx.doi.org/10.18821/1560-9588-2016-19-6-359-364.
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Alopecia areata is a poliethiologic immune mediated condition, associated with lesion of the hair follicles, leading to disruption of growing cycle and subsequent hair loss. Taking into account the different age of patients and repeated recurrence despite of the therapy, as well as changes in the appearance of the individual affecting psychosocial status, patchy hair loss refers to the category of socially important disorders. The introduction of computer technologies facilitated diagnostic approaches through developing of specific criteria for the diagnosis of alopecia areata, which improved its differentiation with similar dermatological conditions. This publication intended to review and analyze of clinical cases of several dermatological disorders which remind clinics of different forms of alopecia areata. The importance of trichoscopy was shown to provide differential diagnosis in various hair-loss conditions to evaluate morphometric hair and skin characteristics.
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Das, Koushik. "Formulation and Evaluation of Herbal Facewash Preventing Dermatological Problem." International Journal for Research in Applied Science and Engineering Technology 11, no. 6 (2023): 2216–25. http://dx.doi.org/10.22214/ijraset.2023.54016.
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Abstract: Facewash is one type of cosmeceuticals as well as semisolid dosage forms used for external purposes. It is applied on the skin surface to protect the skin from various microbial attacks. This type of cosmeceutical is also used to clean different types of skin problems like skin acne, skin pimples, skin rashes, dark circles, black spot, oily skin, skin discolored, etc. In this study, we have formulated one herbal face wash containing different extraction of herbal materials like fresh aloevera gel, leaves of neem, turmeric, lemon juice, Fresh leaves of Tulsi, fresh pudina leaves, Chandan, liquorice, Honey, Coffee, Multani mati, rose water as well as various types of excipients like sodium CMC, sodium lauryl sulphate, sodium benzoate, glycerol and distilled water. After formulation study we focused the evaluation cum validation of the formulated new herbal facewash like testing of pH ,Spreadability test, foam forming test, etc.
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Cauli, Alberto, Dafna D. Gladman, Alessandro Mathieu, et al. "Physician’s Global Assessment in Psoriatic Arthritis: A Multicenter GRAPPA Study." Journal of Rheumatology 45, no. 9 (2018): 1256–62. http://dx.doi.org/10.3899/jrheum.171183.
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Objective.Physician’s global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. This study assesses the reliability of the PGA, measured by means of 0–100 mm visual analog scale (VAS), and the additional use of separate VAS scales for musculoskeletal (PhysMSK) and dermatologic (PhysSk) manifestations in patients with psoriatic arthritis (PsA).Methods.Sixteen centers from 8 countries enrolled 319 consecutive patients with PsA. PGA, PhysMSK, and PhysSk evaluation forms were administered at enrollment (W0) and after 1 week (W1). Detailed clinical data regarding musculoskeletal (MSK) manifestations, as well as dermatological assessment, were recorded.Results.Comparison of W0 and W1 scores showed no significant variation (intraclass correlation coefficients were PGA 0.87, PhysMSK 0.86, PhysSk 0.78), demonstrating the reliability of the instrument. PGA scores were dependent on PhysMSK and PhysSk (p < 0.0001) with a major effect of the MSK component (B = 0.69) compared to skin (B = 0.32). PhysMSK was correlated with the number of swollen joints, tender joints, and presence of dactylitis (p < 0.0001). PhysSk scores were correlated with the extent of skin psoriasis and by face, buttocks or intergluteal, and feet involvement (p < 0.0001). Finally, physician and patient assessments were compared showing frequent mismatch and a scattered dot plot: PGA versus patient’s global assessment (r = 0.36), PhysMSK versus patient MSK (r = 0.39), and PhysSk versus patient skin (r = 0.49).Conclusion.PGA assessed by means of VAS is a reliable tool to assess MSK and dermatological disease activity. PGA may diverge from patient self-evaluation. Because MSK and skin/nail disease activity may diverge, it is suggested that both PhysMSK and PhysSk are assessed.
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Yue, Zhiying, Dan Zhou, Mingli Zeng, Junying Li, and Rujun Zheng. "Drug prescription for the management of gastrointestinal and skin symptoms in cancer patients by advanced practice nurses in China: a Delphi method." BMJ Open 15, no. 3 (2025): e089803. https://doi.org/10.1136/bmjopen-2024-089803.
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BackgroundThe authority to prescribe drugs has been reserved only for the medical community, mainly clinicians. Recently, more and more countries worldwide have begun implementing reforms to grant advanced practice nurses (APNs) the authority to prescribe from the legislative level. This study aimed to explore the prescription drugs and forms for gastrointestinal and dermatological symptom management of cancer patients that APNs can prescribe in China.DesignA qualitative study reported in accordance with Conducting and REporting of DElphi Studies guidelines. The modified Delphi technique with two-round email consultations among 36 experts was applied.MethodsWe conducted a study from January 2022 to March 2022 to reach a consensus among medical, nursing and pharmacy experts about drugs that nurses may prescribe for gastrointestinal and dermatological symptom management in cancer patients.ResultsThe expert authority coefficients are 0.95 and 0.96, respectively. A total of 35 drugs in 16 categories could be prescribed by APNs for gastrointestinal and dermatological symptoms management in China. Among them, three drugs were determined to be prescribed collaboratively, and 32 drugs were determined to be prescribed independently.ConclusionsThe drug prescription formulated in this study is the basis for APNs to prescribe drugs for controlling gastrointestinal and skin symptoms for cancer patients in mainland China. The results are important as a guide for formulating and implementing policies related to nurse prescribing and will provide some reference for future nurse prescribing in China.
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Shtuchna, NI, and SS Zuіkina. "Extemporal suspensions in the scheme of complex therapy of Dermatological skin diseases." Annals of Mechnikov Institute, no. 3 (September 12, 2022): 54–61. https://doi.org/10.5281/zenodo.7071075.
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<strong>Introduction.</strong> The relevance of the study of acne (Acne vulgaris) depends on its significant prevalence among young and middle-aged people and the chronic course of the disease, resistance to conventional therapy, and impaired psycho-emotional status and social adaptation in patients. Acne affects 9.4 % of the world’s population. Therefore, this disease remains one of the most common problems in the practice of dermatologists and cosmetologists. In 64 and 43 % of people, acne persists until the age of 20-30, respectively, and suicidal thoughts are more common in those with severe forms of acne than with mild ones. In the United States, the cost of acne in terms of treatment and productivity loss is over $ 3 billion per year. <strong>Materials and methods. </strong>In the work are used bibliosemantic, analytical, logical and marketing research methods. <strong>Results and dscussion.</strong> In the aspect of the researched problem, the materials of State Register of Medicinal Products of Ukraine, Protocol on the provision of medical assistance to patients with vulgar acne, Addendum to the order of the Ministry of Health No. 312 of 08-05-2009, the provisions of the guidelines of the American Academy of Dermatology on the treatment of patients with acne vulgaris and the Guidelines for the treatment of patients with acne vulgaris within the limits of primary and specialized medical care (Great Britain) were studied. Using pharmacotechnological methods, technology was developed and quality indicators of several extemporaneous suspensions for complex pharmacocorrection of acne were investigated. <strong>Conclusion.</strong> Etiopathological factors of acne, types, forms and approaches to treatment are analyzed. The range of medicinal products for the treatment of acne according to the ATS classification by manufacturers and types of dosage forms has been developed. The perspective of local application of pharmaceutical suspensions of extemporaneous production in the scheme of complex pharmacocorrection of acne has been proven. An analysis of the extemporaneous formulation was carried out and a number of prescriptions of extemporaneous suspensions for the complex therapy of dermatological skin diseases were proposed. The regulatory framework and requirements of the DFU, the European and American Pharmacopoeia for APIs and auxiliary substances in the composition of extemporaneous suspensions were analyzed. The current evidence base of Ukraine, Great Britain and the USA regarding the algorithm of treatment and pharmacotherapeutic support of acne was analyzed
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Levshin, Roman Nikolayevich, K. Yu Fedotova, and K. V. Kotenko. "THE EFFECTIVENESS OF PHOTOTECHNIQUES AND CALCINEURIN INHIBITOR IN PATIENTS WITH LICHEN PLANUS." Russian Journal of Physiotherapy, Balneology and Rehabilitation 16, no. 5 (2017): 257–61. http://dx.doi.org/10.18821/1681-3456-2017-16-5-257-261.
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Lichen planus refers to a common chronic inflammatory diseases of the skin. From lichen planus suffers 0.1% to 2.4% of the population. In most patients, the process has a tendency to relapsing course, and the methods of relief of exacerbations mainly include the use of corticosteroids, which have side effects. In recent years there have been few studies of the effectiveness of narrowband ultraviolet therapy, polychromatic polarized light, however, the problem of therapy of patients with lichen planus remains relevant. Under our observation there were 62 patients in age from 20 to 54 years with different clinical forms of lichen planus. Patients of the main group additionally received pulsed polarized light therapy and a topical inhibitor of calcineurin, patients of comparison groups received pulsed polarized light therapy or a topical inhibitor of calcineurin. Evaluation of effectiveness was based on clinical (dermatological indexes) and special methods (biochemical, immunological). The use of the combined method in patients with lichen planus caused high therapeutic and preventive effects, as evidenced by the improvement indices dermatologicaly status and improving the quality of life, positive dynamics of the content of histamine, expression of Toll-receptors according to the direct and remote observations.
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Kravchenko, V. G., Ya A. Emchenko, A. V. Kravchenko, and A. M. Dashchuk. "Psorias: current status of incidence and organizational measures." Ukrainian Journal of Dermatology, Venerology, Cosmetology, no. 3-4 (December 5, 2022): 42–48. http://dx.doi.org/10.30978/ujdvk2022-3-4-42.
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Objective — to conduct an epidemiological analysis of the incidence of psoriasis in the world and in Ukraine and to determine the reasons for its permanent spread, as well as to outline the main tasks of the dermatovenerological field to improve the situation in our country.
 Materials and methods. In order to conduct a comparative analysis, available data from epidemiological studies and our own long-term dermatological practice were used.
 Results and discussion. Quite high prevalence rates of psoriasis in economically developed countries can be considered as a reflection of the existing organizational health care system and high level of medical care. Analytical data on the incidence of psoriasis in certain regions of Ukraine indicate a significant prevalence of this dermatosis, even in the absence of strict registration of diseases in the regions. The therapy of psoriatic disease, especially its complicated forms, is currently accompanied by significant difficulties and does not provide long-term remission. Therefore, the treatment of such patients must be carried out in specialized dermatovenerological institutions, in which the necessary personnel and material resources and special medical equipment should be concentrated.
 Conclusions. In order to carry out effective measures in the fight against psoriatic disease and its consequences, dermatological units of municipal and private property should establish accounting and reporting on the morbidity. The presidium of the UALDVK should create a clear plan of measures for the earliest possible detection, treatment and prevention of complications of dermatosis, as well as, develop algorithms and protocols for the treatment of patients with various clinical types and forms of psoriasis on the basis of the latest national and international scientific achievements. Only the joint efforts of the association of dermatologists and a significant part of the medical community (pediatricians, cardiologists, endocrinologists, immunologists) under the leadership of the National Health Service of Ukraine and the Ministry of Health of Ukraine can defeat this disease, since the epidemiological and therapeutic aspects of psoriasis are not purely dermatological problems.
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Stehlgens, Jéssica Lima, Weison Lima da Silva, and Amanda Bezerra Carvalho. "BIOCOSMÉTICOS AMAZÔNICOS: A UTILIZAÇÃO DO AÇAÍ (EUTERPE OLERACEAMART.) EM ESTÉTICA E DERMATOLOGIA." Revista ft 29, no. 140 (2024): 43–44. http://dx.doi.org/10.69849/revistaft/ar10202411151643.
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Introduction: This study aims to investigate the potential of açaí as an active ingredient in dermatological products, exploring its antioxidant, anti-inflammatory and regenerative properties. General objective: to investigate the potential of açaí as an active ingredient in dermatological biocosmetics and its therapeutic properties for skin health. Methodology: this is a systematic review of the literature following the PRISMA methodology. The research was conducted between August and October 2024, using databases such as PubMed, SciELO and LILACS, with descriptors related to the use of açaí in biocosmetics and dermatology. Results: 147 studies were identified, of which 122 underwent initial screening. After applying the PRISMA criteria, 45 studies were fully evaluated and 12 were selected for detailed analysis. The results of the study show that açaí has a high content of anthocyanins, flavonoids and fatty acids, responsible for its antioxidant, anti-inflammatory and regenerative properties, ideal for dermatological cosmetics. These biomolecules help in the treatment of conditions such as psoriasis, acne and premature aging, in addition to promoting skin hydration and elasticity. Açaí is used in various pharmaceutical forms, such as extracts and creams, demonstrating versatility in the biocosmetics market. Conclusion: Açaí has shown to be a promising ingredient in biocosmetics and dermatology, due to its therapeutic properties. However, the effectiveness of açaí depends on the pharmaceutical form used, suggesting the need for standardization of extracts and more clinical studies to evaluate their applications and benefits in different skin types.
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Shtrimaitis, O. V., O. S. Kukhtenko, and D. P. Soldatov. "Determination of rheological parameters of gels used in the treatment of dermatological skin diseases." News of Pharmacy 109, no. 1 (2025): 9–16. https://doi.org/10.24959/nphj.25.168.
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Aim. To study the rheological parameters of medicinal and cosmetic products that are available in the Ukrainianpharmaceutical market in the form of a gel for the treatment of dermatological diseases (acne) in order to determinethe acceptability criteria when assessing the rheological properties of gels.Materials and methods. The study objects were medicines containing retinoids (adapalene and tretinoin) and acosmetic product (a therapeutic and preventive gel). The rheological properties of the gel samples were assessed using a Rheolab QC rotational rheometer (Anton Paar) equipped with a C-CC27 / SS coaxial cylinder system.Results. The results of rheological studies depend on the experimental conditions and the equipment used.The challenge in assessing rheological properties lies in the absence of specific values for soft dosage forms, whichmakes it difficult to assess the values obtained and determine compliance. Therefore, due to the lack of universalcriteria for assessing rheological parameters and the necessity to determine acceptable rheological property rangesin the development of soft dosage forms containing retinoids, it became essential to establish acceptable rheologicalparameter ranges on the example of existing gel forms for treating acne. Analyzing the shear stress range values, inwhich the flow curves are located, it can be determined that acceptable ranges for the new drug being developed arethe shear stress range of 25–100 Pa under similar or approximate experimental conditions. The initial viscosity of thegels studied ranges from 30 to 100 Pa·s.Conclusions. The experimental studies have demonstrated that the gels presented in the study exhibit highthixotropic properties, indicating significant structural recovery after mechanical deformation caused by the measuringsystem inner cylinder. The acceptable shear stress range for the new drug being developed should be within 25–100 Pa undersimilar or approximate experimental conditions. The gels have been identified as pseudoplastic dispersed systems.As the initial viscosity of the gels studied ranges from 30 to 100 Pa·s, it must be considered when developing a newpharmaceutical product for the treatment of dermatological diseases
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Nair, Anroop, Shery Jacob, Bandar Al-Dhubiab, Mahesh Attimarad, and Sree Harsha. "Basic considerations in the dermatokinetics of topical formulations." Brazilian Journal of Pharmaceutical Sciences 49, no. 3 (2013): 423–34. http://dx.doi.org/10.1590/s1984-82502013000300004.
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Assessing the bioavailability of drug molecules at the site of action provides better insight into the efficiency of a dosage form. However, determining drug concentration in the skin layers following topical application of dermatological formulations is a great challenge. The protocols followed in oral formulations could not be applied for topical dosage forms. The regulatory agencies are considering several possible approaches such as tape stripping, microdialysis etc. On the other hand, the skin bioavailability assessment of xenobiotics is equally important for topical formulations in order to evaluate the toxicity. It is always possible that drug molecules applied on the skin surface may transport thorough the skin and reaches systemic circulation. Thus the real time measurement of molecules in the skin layer has become obligatory. In the last two decades, quite a few investigations have been carried out to assess the skin bioavailability and toxicity of topical/dermatological products. This review provides current understanding on the basics of dermatokinetics, drug depot formation, skin metabolism and clearance of drug molecules from the skin layers following application of topical formulations.
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Dr., Sudipto Debnath* Manosi Das Debajyoti Das Susmita Roy Simmi Mall Ajay K. Meena Gajji Babu. "A Brief Overview of Panchanimba Churna: A Classical Ayurvedic Formulation for Skin Disorders." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 1458–88. https://doi.org/10.5281/zenodo.14685608.
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Ayurvedic Churna is one of the most basic forms of Ayurvedic medicine and can be prepared easily. The Churna one will make should be referenced from an established Ayurvedic text or the Ayurvedic Formulary of India (AFI). Panchanimba Churna, an Ayurvedic formulation referenced in Bhaisajya Ratnavali and AFI (Part II), has attracted interest for its therapeutic potential in managing various health conditions, particularly skin disorders. This review examines the pharmacological properties, traditional uses, and contemporary research findings related to the Panchanimba churna. Sourced from the neem tree (Azadirachta indica), this churna possesses notable antimicrobial, anti-inflammatory, and antioxidant properties. Traditionally, it has been used to treat skin issues such as eczema, acne, and psoriasis, with modern research supporting its effectiveness in reducing inflammation, fighting microbial infections, and promoting skin healing. Additionally, Panchanimba churna shows promise in complementary therapies for dermatological conditions, highlighting its potential as a valuable alternative treatment in integrative medicine. This review consolidates current knowledge and emphasizes the therapeutic relevance and future research opportunities of Panchanimba churna in dermatological care.
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Novik, Viktor, and D. Dreval. "CYTOLOGICAL DIAGNOSIS AS A METHOD OF SCREENING OF PRE-MALIGNANT MELANOCYTIC TUMORS AND EARLY FORMS OF SKIN MELANOMA." Problems in oncology 64, no. 3 (2018): 384–87. http://dx.doi.org/10.37469/0507-3758-2018-64-3-384-387.
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Cytohistological comparisons to the account of the clinical data and revision of cytological and histological preparations on a material received from 21 patients are made. Cytomorphological features of juvenile nevi (Spitz-nevus, Reed-nevus), dysplastic and atypical nevi and early forms of melanoma are described. The establishment at cytological examination of good-quality character of melanocytic defeats at the account of the clinical data could be the basis for appointment laser therapy. At revealing of atypical melanocytes in cytological preparations patients should be referred to specialized oncological institutions for surgical excision of tumor with the subsequent histological examination. Thus cytological examination could be used in dermatological practice as a method of screening pre-malignant melanocytic tumors and skin melanoma.
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Patil, Priyanka C., Vishalakshi Viswanath, Pradnya R. Joshi, and Mayuri Dhakne. "A Cross-Sectional Survey to Evaluate the Influence of the COVID-19 Pandemic on Treatment Adherence in Chronic Dermatological Diseases." Clinical Dermatology Review 7, no. 3 (2023): 252–57. http://dx.doi.org/10.4103/cdr.cdr_32_21.
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Background: The COVID-19 pandemic and subsequent nationwide lockdowns have contributed to complex problems in the management of chronic dermatological diseases. Objectives: The objective of this study is to evaluate the impact of the COVID-19 pandemic on the management of chronic dermatological diseases treated with/without systemic immunomodulators and phototherapy. Materials and Methods: A single-center, cross-sectional, questionnaire-based survey via telephone calls/Google Forms was conducted from May 2020 to July 2020. Multivariate correlation analysis with adherence to treatment as dependent variable was performed to study the influence of various demographic variables, treatment-related factors, and pandemic issues. Results: Data of 138 patients (55% with psoriasis, 21% with vesiculobullous diseases, 18.2% with connective tissue diseases, and 5.8% with conditions such as alopecia areata, vitiligo, lichen planus, and reactive arthritis) were analyzed. The study population consisted of 81.1% of patients on systemic immunomodulators. Autonomous treatment modification was reported by 77% leading to poor disease control in 53.7%. There was a statistically significant negative correlation between income loss during the pandemic and treatment adherence. Duration of illness also showed a significant negative correlation, thereby indicating that treatment adherence reduced with disease chronicity. The highest nonadherence was noted with apremilast. None of the patients reported confirmed COVID infection. Conclusions: The study findings emphasize the direct and indirect effects of the COVID-19 pandemic on treatment adherence in chronic dermatological diseases. It underlines the need for better pandemic response by the development of patient education programs, standard protocols, and functional teledermatology units in Indian public health-care settings.
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Varsha, Mary Mathai1*and Sherin B. Sarangom1. "Indolent Ulcer in Cats." Science World a monthly e magazine 3, no. 9 (2023): 2467–68. https://doi.org/10.5281/zenodo.8395604.
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Feline indolent ulcers, also known as rodent ulcers or eosinophilic ulcers, are common dermatological conditions affecting cats. Only a few authors have reported the condition in dogs (Kim <em>et al.</em> 2010). It is a condition included among Eosinophilic Granuloma Complex which also includes two other forms, the eosinophilic plaque and eosinophilic granuloma. Manning <em>et al.</em> (1987) has reported the coexistence of all the three forms in one animal. The presentation of lesions are either unilateral or bilaterally symmetrical or asymmetrical and usually occur on the upper lip close to the philtrum. They also appear on other parts of the body. The ulcers are painless, non-pruritic and usually associated with submandibular lymphadenopathy. They are depressed, reddish, circumscribed lesions with raised borders. In some cases, ulcers are preceded by swollen lips.
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Mironchuk, T. M., and Zh M. Polova. "Analysis of the range of medicines for the treatment of the wound process." News of Pharmacy 109, no. 1 (2025): 88–93. https://doi.org/10.24959/nphj.25.162.
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Aim. To study the range of medicines that promote wound healing in the pharmaceutical market of Ukraine. Materials and methods. The study objects were the State Register of Medicines, tabletki.ua website, patient information leaflets. Analytical and statistical methods of analysis were used in the study. Results. After analyzing the market of wound-healing medicines, it has been found that according to the ATC classification, the group of medicines studied belongs to the ATC group D “Dermatological agents”. The study has found that 81.7 % of medicines are of domestic production, while 18.3 % are of foreign production. The most common are soft dosage forms – 50.4 %; the second position is occupied by liquid dosage forms – 48 %; the least drugs belong to solid dosage forms – 1.6 %. Conclusions. After analyzing the entire range, it has been found that there are no probiotic medicines for local use in the pharmaceutical market. Therefore, there is a need for further research and development of wound-healing drugs with a probiotic effect for topical use.
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Varzhapetyan, Asmik A., I. Yu Dorozhenok, and K. M. Lomonosov. "VITILIGO AND COMORBID PSYCHOSOMATIC DISORDERS." Russian Journal of Skin and Venereal Diseases 22, no. 1-2 (2019): 33–38. http://dx.doi.org/10.17816/dv42934.
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Vitiligo is a chronic idiopathic disease characterized by appearance of depigmented spots and discolored hairs in various parts of the body due to the destruction and reducing the number of melanocytes. Despite the absence of somatogenic appearance psychosomatic aspects of vitiligo are extremely relevant to study in view of high psychosocial significance associated with the pronounced stigmatizing effects. 62 vitiligo patients were examined. Among comorbid psychosomatic disorders there were found out psychogenic manifestations - 25 (40.3%) and nosogenic reactions due to stress effect of the dermatosis - 37 (50.7%): sociophobic - 17, masked hypochondria - 13, overvalued hypochondria of beauty - 7 patients. Psychogenic manifestations with the participation of objectively severe and subjectively significant factors can attribute vitiligo to psychosomatic skin diseases. In the clinical picture of nosogenic disorders, various forms of dissociation between the prevalence of dermatosis and subjective reaction to the cosmetic defect were revealed, which is due to the structure of the personality and somatoperceptive accentuation of the patient. The results can be implemented in dermatological practice, which will significantly optimize the treatment and compliance of patients with vitiligo. Objective: a complex clinical (dermatological, psychopathological) and psychological study of psychosomatic disorders in vitiligo.
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Akashdeep, R. Udmale* Pranav N. Jain Mukeshkumar V. Choudhary. "MICROEMULGEL AS A NOVEL APPROACH FOR ENHANCING TOPICAL DRUG DELIVERY: A REVIEW." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 02 (2019): 4803–8. https://doi.org/10.5281/zenodo.2586072.
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<em>Topical drug delivery is a localized drug delivery system anywhere in the body through ophthalmic, rectal, vaginal & skin as topical routes. These are apply a wide range of preparations for both cosmetic and dermatological to their healthy or diseased skin Microemulgel have emerged as one of the most intresting topical delivery system as it is a dual control release system i.e gel & emulsion. Both hydrophilic & hydrophobic types of drugs are incorporated into dosage forms. The major objective behind this formulation is delivery of hydrophobic drugs to systemic circulation via skin. Topical drug delivery has the main advantage of direct delivery of the drug to the target tissue i.e. skin & mucous membranes, by passing the first pass effect. Microemulgel with its micron sized globule has better penetration & with gelling property exhibit control drug release. The Microemulgel for dermatological & Cosmetic use have different favorable properties such as being thixotropic, easily spreadable, Non staining, emollient, bio-friendly, clear, transparent & elegant appearance, & these Microemulgel based formulations enhances the skin deposition of API , thereby ultimately enhancing its therapeutic activity.</em> <strong>Keywords: </strong><em>Microemulgel, Topical drug delivery, hydrophobic drugs</em><strong><em>.</em></strong>
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Tamrazova, O. B., G. A. Novik, A. V. Tamrazova, G. E. Bagramova, and M. V. Zhdanova. "Diagnosis and treatment of local forms of alopecia areata in children." Russian Journal of Clinical Dermatology and Venereology 24, no. 3 (2025): 358. https://doi.org/10.17116/klinderma202524031358.
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Alopecia areata (AA) is a genetically caused chronic autoimmune disease, which is characterized by nonscarring temporary or persistent hair loss. The prevalence of this disease has increased in recent decades, and currently up to 3.83% of patients in dermatological facilities seek care with the problem of focal hair loss. The incidence of AA in children increases with age. Thus, the highest prevalence is recorded among adolescents aged 12—17 years. It has also been observed that concomitant autoimmune diseases are 2.59 times more often found in children with AA than in children without AA. Focal hair loss affects everyday life, always significantly reducing the quality of life. AA multifactorial pathogenesis, recurrent course as well as visible cosmetic defect necessitate a comprehensive approach in the diagnosis and treatment of this condition, as well as the most effective modern treatment methods application. The article discusses epidemiology, etiology, development mechanisms, clinical features of AA, describes the main methods of diagnosis and control of performed therapy, particularly trichoscopic signs, presents the most commonly used scales for determining the process severity as well as modern methods of managing patients with localized form of the disease, practical application of which is demonstrated in a clinical case.
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Samtsov, Alexey V., Evgeny V. Sokolovskiy, Natalia P. Teplyuk, Irena E. Belousova, Muza M. Kokhan, and Elena V. Matushevskaya. "Revisiting the question of pemphigus classification." Vestnik dermatologii i venerologii 97, no. 2 (2021): 9–15. http://dx.doi.org/10.25208/vdv1216.
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Analysis of various classifications of pemphigus shows that there are no fundamental differences between them. The main distinctions consist in use of diverse terms in naming of some forms of pemphigus and in inclusion or exclusion of certain subtypes from the classifications. Authors propose to use the following classification in the dermatological clinical practice, for educational and scientific purposes and for clinical guidelines: 1) pemphigus vulgaris (1.1. Pemphigu s vegetans); 2) pemphigus foliaceus (2.1. Pemphigus endemic (Fogo selvagem), 2.2. Pemphigus erythematosus (Senear Usher)); 3) herpetiform pemphigus; 4) paraneoplastic pemphigus; 5) IgA pemphigus (5.1. Subcorneal pustular dermatosis, 5.2. Intraepidermal neutrophilic dermatosis).
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Gacem, Ourida, Djohra Hadef, and Mohamed Samir Ladj. "Skin involvement of juvenile scleroderma." Journal of Dermatology & Cosmetology 7, no. 4 (2023): 129–34. http://dx.doi.org/10.15406/jdc.2023.07.00249.
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Pediatric scleroderma is a rare chronic inflammatory disease in children. It includes two major clinical entities, systemic sclerosis (SSc) and localized scleroderma (LS). The two forms have a common mechanism but their clinical manifestations differ. Skin involvement occupies an important place in diagnostic classifications due to the richness of dermatological clinical manifestations and their suggestive aspect of the disease. If the vital prognosis is often not compromised, the functional prognosis is strongly affected, sometimes with deleterious aesthetic problems. Very few pediatric publications have been produced. In this article, we report the different skin manifestations inherent to this disease, and their management in children.
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Ochelenko, S. A., K. N. Monakhov, S. A. Ochelenko та K. N. Monakhov. "ТHE EFFICIENCY AND SAFETY OF CALCINEURIN INHIBITORS (TACROLIMUS) IN ATOPIC DERMATITIS AND OTHER DERMATOLOGICAL DISEASES". Russian Journal of Allergy 8, № 2 (2011): 89–95. http://dx.doi.org/10.36691/rja820.
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The problems of clinical efficiency and safety of application of tacrolimus (Protopik) at various skin diseases are discussed in this review. High efficiency of this drug, allows to use it in treatment of different dermatosis. The clinical effect is comparable with topical corticosteroids, and the rate of adverse effects is lower. It is possible to use long applications of calcineurin inhibitors in patients with resistant forms of atopic dermatitis. Positive effects of application of tacrolimus in vitiligo, balanitis, alopecia areata etc. are described.
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Zanutto, Marcelo de Souza, Larissa Cristina Alonso, and Mirella Tomaz Soares. "Demodicosis in domestic cats – a review." Clínica Veterinária XXVII, no. 159 (2022): 44–53. http://dx.doi.org/10.46958/rcv.2022.xxvii.n.159.p.44-53.
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Demodicosis is an uncommon disease in the clinical-dermatological routine of felines. It can be caused by the Demodex gatoi or Demodex cati, and a new, as yet unnamed species has been reported. Numerous forms of diagnosis and therapeutic protocols have been reported for canine demodicosis for years. However, there are few current studies on the subject in felines. Therefore, the present work aims to carry out a literature review on this skin disease, with a description of its etiology, epidemiology, clinical signs, diagnosis and current forms of treatment, as feline demodicosis still has a therapeutic and diagnostic difficulty because it is a rare and low-incidence disease. Future studies are still needed to reach a better understand of the disease and to define a more concise therapeutic protocol, including standardization of doses and frequency of administration.
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Deepti Dwivedi, Alok Kumar Shukla, and Satya Prakash Singh. "Phytosomes - An emerging approach for effective management of Dermatological Disorder." International Journal of Research in Pharmaceutical Sciences 13, no. 1 (2022): 8–14. http://dx.doi.org/10.26452/ijrps.v13i1.11.
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The word ”Phyto” means plant, and also sometimes, it can be signified as cell- like. The development of phytosomes produces a little cell by itself, by which the active ingredient of the herbal extracts is protected from the intestinal secretions and instinctive bacteria destruction. The introduction of phyto- somes into herbal formulation is very recent and useful because they have advanced bioavailability, and they are better absorbed. Also, they consume this enhanced ability to cross lipid-rich bio membranes to finally reach the blood. Phytosomes can also be defined as complex chemical mixtures which are formulated by countering more than one mole synthetic or natural phos- pholipids phosphatidyl ethanolamine or phosphatidylserines with the one mole of another component. There are various plants materials which can be merged in the process of phytosomes, such as several herbal extracts includ- ing quercetin, grape seed, Rhein, neem, green tea, aloe vera, marigold and ginseng. The bioavailability of phytosomes further as linked to conventional herbal extracts because it has enhanced capability to penetrate the lipid bio membrane to finally reach the systemic blood circulation. Phytosomes has been categorized as a novel line for herbal drug delivery. Various conven- tional dosage forms such as gels and creams remained expressed using these constituents, but they appeared to be a better dermatological effect. Hence, phytosomes were formulated by binding phosphatidylcholine (acts as a trans- porter and protect the skin) and herbal extracts. They consist of a phospho- lipid molecular structure which includes two fat-soluble tails and a water- soluble head, and because of its dual solubility, it was absorbed better and was also used for the treatment of skin carcinomas, antiaging and skin disorders.
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Fedota, O. M., Yu O. Sadovnychenko, L. V. Roshchenyuk, V. M. Vorontsov, and P. P. Ryzhko. "Study of prevalence of different forms of ichthyosis in Kharkiv region." Faktori eksperimental'noi evolucii organizmiv 23 (September 9, 2018): 244–48. http://dx.doi.org/10.7124/feeo.v23.1022.
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Ichthyosis is genetically and clinically heterogenic group of epidermis keratinization disorders. Its prevalence is geographically different. Aim. The aim of this research was to evaluate ichthyosis prevalence in Kharkiv region. Methods. The collection of clinical-genealogical history was carried out by the method of single registration of the proband on the basis of the Regional Clinical Dermatological and Venereological Health Center No. 1 and the Dermatovenerological Health Centers of the Kharkiv Region in 2017. Results. The ichthyosis prevalence in Kharkiv region was 2.5·10–4 in 2017. The ichthyosis prevalence varied from 6.7∙10‑5 in Krasnohrad district to 1.0∙10‑3 in Dvorichna district. The least prevalence was in the population of Vovchansk city (1.1∙10‑4) and the highest one was in the population of Dvorichna city (10.7∙10‑4). The differences between the prevalence of ichthyosis vulgaris in Kharkiv region in 2008-2017 were established. Conclusions. It was found that the decrease of ichthyosis prevalence in Kharkiv region was 1.6 times during last 10 years. This index for ichthyosis vulgaris was decreased 1.9 times at the same period. Monogenic dermatoses, as an example of ichthyosis, can be used both to monitor the burden of genetic disorders in the region and to solve the problems of general and personal genetic safety in the population.
 Keywords: ichthyosis vulgaris, X-linked recessive ichthyosis, prevalence.
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Kumar, Ujjwal, Krishnendra Varma, and Ankur Shayalwar. "Nail changes in various dermatoses: an observational study conducted at tertiary care center, Ujjain, Madhya Pradesh, India." International Journal of Research in Dermatology 6, no. 2 (2020): 237. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20200603.
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<p class="abstract"><strong>Background:</strong> Nail apparatus forms an integral part to be examined for all dermatological conditions. Nail changes are seen in various dermatosis like psoriasis, onychomycosis, lichen planus, collagen vascular disease, vesicobullous diseases and other papulosquamous diseases. Aims and objective of the study was to determine the prevalence of nail changes in various dermatological conditions.</p><p class="abstract"><strong>Methods:</strong> After applying inclusion and exclusion criteria, 269 cases with various nail changes were enrolled in the study. Detailed history and thorough nail examination was carried out along with other necessary investigations like CBC, RFT, LFT, nail clipping for fungal hyphae culture and microscopy.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 269 cases with nail disorders, male to female ratio was 1.5:1 and most common age group was 31-40 years. The most common abnormality observed was onychomycosis (34.2%) followed by nail changes in psoriasis (30.4%), LP (18.5%), eczema (4%), trachonychia (3.3%), paronychia (2.9%), lichen striatus (2.2%) and darier’s disease (0.37%). Among onychomycosis most common pattern observed was DLSO (82.6%) followed by PSO (7.6%), SWO (5.4%) and TDO (4.34%). The pattern of nail changes in psoriasis patients was pitting (30.4%), subungual hyperkeratosis (21.9%) and onycholysis (10.9%). Cases with LP had longitudinal striations (52%), thinning of nail plate and trachonychia (10% each). V shaped notching and distal splitting was seen in one of the Dariers’ disease patient.</p><p class="abstract"><strong>Conclusions:</strong> Nail changes form an indispensible part of various dermatological conditions. The pattern of involvement is unique in each and every disease. Hence examination of all the 20 nails should never be missed.</p>
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Patel, Narsingh, Anita Sharma, and Amol Sudhakar Kadu. "An Exploratory Review of Kushthaghna Mahakashaya in Skin Disorders w.s.r. to Visha." International Research Journal of Ayurveda & Yoga 05, no. 02 (2022): 118–23. http://dx.doi.org/10.47223/irjay.2022.5221.
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Background: The Ayurveda treatises are collection of vast knowledge regarding medical and environmental aspects. It has a separate branch called Agada Tantra which deals with the toxicological aspects. We aim to evaluate this knowledge regarding dermatological manifestation due to Visha (toxins) vis-à-vis contemporary knowledge. Objective: The objective of this study is to analyze the rationality and applicability of Kushthaghna Mahakashaya in the prevention and management of skin disorders caused by various type of poisons. Data Source: The references available in classical texts, various Nighantu and research articles regarding the various forms of poisons and their dermatological manifestations were analyzed and compared to the knowledge available in contemporary medical literatures. Review methods: A sincere study of classical Ayurveda text-books and their available commentaries along with modern texts, websites and articles has been done to explore the importance of Kushthaghna Mahakashaya in various skin diseases. Result and conclusion: The herbs mentioned in the Kushthaghna Mahakashaya were scientifically evaluated in various preclinical and clinical studies and showed antiviral, immune-modulatory, anti-inflammatory, antioxidant, anti-cancerous, cardio-protective, neuroprotective, anti- fungal, and anti- bacterial activity, according to the results of the literature quest. The proper application of Kushthaghna Mahakashaya plants will aid in the prevention and treatment of skin diseases.
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Samtsov, Alexey V., Alexandr V. Patrushev, Kseniya O. Chepushtanova, et al. "A Prospective Open-Label Study of the Antifungal Activity of External Forms of Activated Zinc Pyrithione in the Treatment of Malassezia- Associated Skin Diseases." Dermatological Health 1, no. 2 (2023): 25–39. http://dx.doi.org/10.26689/dh.v1i2.5502.
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Background: There are insufficient data on the antifungal activity of active zinc pyrithione, which is widely used in practice. Considering the reported role of Malassezia spp. in the pathogenesis of several dermatologic diseases, it is of scientific and practical importance to investigate this issue. Aim: To evaluate the antifungal activity of external forms of activated zinc pyrithione in the treatment of psoriasis, seborrheic dermatitis, and pityriasis versicolor. Method: An open-label prospective study was conducted between March and July 2022. Patients with psoriasis, seborrheic dermatitis, and pityriasis versicolor were treated with external forms of activated zinc pyrithione for 21 days. Skin scales and circular prints from lesion foci, as well as from skin areas without clinical manifestations before and after therapy were studied. A quantitative assessment of skin colonization by micromycetes of Malassezia was performed using microscopic and cultural methods of examination. Clinical efficacy and drug safety of the therapy was assessed using the Dermatological Symptom Scale Index, by recording adverse events at weeks 0, 1, 2, and 3. Results: 64 patients aged 18 to 65 years with diagnoses of psoriasis, seborrheic dermatitis, and pityriasis versicolor were included. 60 patients completed the study, 4 were excluded due to failure to adhere to the schedule. In patients with seborrheic dermatitis and pityriasis versicolor in the lesion foci after therapy, a significant decrease was observed in the colonization level according to the results of microscopic and cultural studies. In psoriasis patients, a significant decrease in the colonization level was obtained only based on the results of microscopic examination. In all groups, significant differences in comparison to the initial level were observed at the 1st week of treatment. There was no adverse events observed. Conclusion: Activated zinc pyrithione in the form of cream and aerosol showed moderate antifungal activity against micromycetes of the genus Malassezia.