Dissertations / Theses on the topic 'Desfluran'
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Folz, Sabine. "Einflüsse von Desfluran versus Isofluran zur Anästhesie auf die intestinale Gewebeoxygenierung bei kontinuitätserhaltenden kolorektalen Eingriffen." Marburg : Görich und Weiershäuser, 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975375539.
Full textSchaarschmidt, Christina. "Vergleichende Untersuchungen zum Aufwachverhalten nach Anästhesie mit Xenon-Desfluran oder Lachgas-Desfluran bei Eingriffen an der unteren Extremität." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967532264.
Full textSalz, Svenja. "Aufwachverhalten von adipösen Patienten nach Narkosen mit Desfluran oder Isofluran." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969410387.
Full textReithmeier, Eberhard Ernst [Verfasser]. "Einsparpotential von Desfluran durch Minimal-Flow in der Einwaschphase / Eberhard Ernst Reithmeier." Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1033588172/34.
Full textStumpner, Jan. "Desfluran induziert ein erstes und ein zweites Fenster der Präkonditionierung gegen Myokardinfarkt in vivo." kostenfrei, 2008. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-27263.
Full textSchlitzer, Peter. "Lachgasfreie Niedrigflussnarkosen mit Desfluran und Remifentanil ein Vergleich zwischen EEG-gestützter und nicht EEG-gestützter Narkoseüberwachung /." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972332642.
Full textOßwald, Christian [Verfasser], and Sascha [Akademischer Betreuer] Kreuer. "Überwachung standartisierter Desfluran-Remifentanil-Anästhesien mittels EEG und akustisch evozierter Potentiale : Multizenterstudie / Christian Oßwald. Betreuer: Sascha Kreuer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1051434750/34.
Full textVogt, Hendrik [Verfasser], Wolfgang [Akademischer Betreuer] Schlack, and Judith [Akademischer Betreuer] Haendeler. "Desfluran induzierte Präkonditionierung: Beteiligung und Regulation zytosolischer Proteine - ein proteomanalytischer Ansatz - / Hendrik Vogt. Gutachter: Wolfgang Schlack ; Judith Haendeler." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2014. http://d-nb.info/1063085101/34.
Full textAydın, Cemalettin Özmen Sadık. "Bis kontrollü tek soluk inhalasyon indüksiyon tekniği ile sevofluran ve desfluran uygulamasının tiroid fonksiyon testleri üzerine etkilerinin karşılaştırılması /." Isparta : SDÜ Tıp Fakültesi, 2002. http://tez.sdu.edu.tr/Tezler/TT00092.pdf.
Full textFrank, Anja [Verfasser], and Markus [Akademischer Betreuer] Lange. "Die Rolle kardialer Beta1- und Beta2-adrenerger Rezeptoren bei der Desfluran-induzierten Postkonditionierung / Anja Frank. Betreuer: Markus Lange." Würzburg : Universitätsbibliothek der Universität Würzburg, 2012. http://d-nb.info/1024658473/34.
Full textHillen, Jana [Verfasser]. "Ein Vergleich der Inhalationsanästhetika Xenon und Desfluran bezüglich der Inzidenz der postoperativen kognitiven Dysfunktionen (POCD) im Alter / Jana Hillen." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1038325994/34.
Full textObendorfer, Markus [Verfasser], and Jeleazcov [Akademischer Betreuer]. "Vergleichende Untersuchung der EEG-Spektren von Isofluran, Desfluran und Sevofluran in äquipotenter Dosierung in der Ratte / Markus Obendorfer. Betreuer: Jeleazcov." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2012. http://d-nb.info/1027850243/34.
Full textAmbrus, Stefan Christoph [Verfasser]. "Untersuchung der Geräte-Charakteristika des Mirus™ (Desfluran) von Pall-GmbH mit Hilfe eines Testaufbaus (Bench-Study) / Stefan Christoph Ambrus." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2018. http://d-nb.info/1233286226/34.
Full textPircher, Rebecca [Verfasser], and H. [Akademischer Betreuer] Schwilden. "Vergleich der analgetischen Potenz von Isofluran, Sevofluran und Desfluran im cross-over Design bei der Ratte / Rebecca Pircher. Betreuer: H. Schwilden." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2012. http://d-nb.info/1018801456/34.
Full textFolz, Sabine [Verfasser]. "Einflüsse von Desfluran versus Isofluran zur Anästhesie auf die intestinale Gewebeoxygenierung bei kontinuitätserhaltenden kolorektalen Eingriffen / vorgelegt von Sabine Folz, geb. Roth." Marburg : Görich und Weiershäuser, 2005. http://d-nb.info/975375539/34.
Full textHilz, Teresa Magdalena [Verfasser], Markus [Gutachter] Lange, and Kai [Gutachter] Schuh. "Die antiapoptotischen Effekte der Pim-1 Kinase im Rahmen der ischämischen und Desfluran-induzierten Postkonditionierung / Teresa Magdalena Hilz ; Gutachter: Markus Lange, Kai Schuh." Würzburg : Universität Würzburg, 2017. http://d-nb.info/114211435X/34.
Full textSchmidt, Johannes [Verfasser], and Markus [Akademischer Betreuer] Lange. "Die Beteiligung der Peroxysomen-Proliferator-aktivierten Rezeptoren α [Alpha] und {γ [Gamma] am zweiten Fenster der Desfluran-induzierten Präkonditionierung / Johannes Schmidt. Betreuer: Markus Lange." Würzburg : Universitätsbibliothek der Universität Würzburg, 2011. http://d-nb.info/1013620135/34.
Full textWeis, Johannes [Verfasser], and Heinrich-Volker [Akademischer Betreuer] Groesdonk. "Aufwachzeiten und Pharmakoelimination im Sedierungsfenster im Rahmen der Studie : Desfluran versus Isofluran zur inhalativen Sedierung kritisch kranker Patienten / Johannes Weis ; Betreuer: Heinrich-Volker Groesdonk." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1205735291/34.
Full textZürl, Julian Klaus [Verfasser], Markus [Gutachter] Lange, and Christoph [Gutachter] Wanner. "Die Rolle der Calcium-Calmodulinkinase II\(_δ\) bei der Desfluran-induzierten Kardioprotektion gegen den Ischämie/Reperfusionsschaden / Julian Klaus Zürl ; Gutachter: Markus Lange, Christoph Wanner." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1193423775/34.
Full textWessendorf, Marcel [Verfasser], and Thomas [Akademischer Betreuer] Volk. "Effizienz der Desfluran-Reflektion in Abhängigkeit von Tidavolumen, Atemfrequenz und Patientenkonzentration in einem Modellversuch : AnaConDa® versus MIRUS™ / Marcel Wessendorf. Betreuer: Thomas Volk." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1113592486/34.
Full textWeis, Johannes [Verfasser], and Heinrich Volker [Akademischer Betreuer] Groesdonk. "Aufwachzeiten und Pharmakoelimination im Sedierungsfenster im Rahmen der Studie : Desfluran versus Isofluran zur inhalativen Sedierung kritisch kranker Patienten / Johannes Weis ; Betreuer: Heinrich-Volker Groesdonk." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://nbn-resolving.de/urn:nbn:de:bsz:291--ds-303759.
Full textGoletz, Christine [Verfasser], Benedikt [Gutachter] Preckel, and Stefan [Gutachter] Topp. "Desfluran-Präkonditionierung am normo- und hyperglykämen Rattenherzen in vivo - Rolle der mitogen-aktivierten Proteinkinasen ERK, JNK und p38 - / Christine Goletz. Gutachter: Benedikt Preckel ; Stefan Topp." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1101693827/34.
Full textAugustin, Knut [Verfasser], and Thorsten [Akademischer Betreuer] Krause. "Experimentelle Untersuchung zur Induktion von Schwester-Chromatid-Ausstauschen in peripheren humanen Lymphozyten durch die Anästhetika Sevofluran, Desfluran, Isofluran & Propofol / Knut Augustin. Betreuer: Thorsten Krause." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/1074642171/34.
Full textBeck, Andreas Erich [Verfasser], Markus [Gutachter] Lange, Rainer [Gutachter] Leyh, and Jan [Gutachter] Stumpner. "Die Rolle des mitochondrialen Kalzium-abhängigen Kalium-Kanals mit großer Leitfähigkeit bei der Desfluran-induzierten Postkonditionierung / Andreas Erich Beck. Gutachter: Markus Lange ; Rainer Leyh ; Jan Stumpner." Würzburg : Universität Würzburg, 2014. http://d-nb.info/111155997X/34.
Full textNeudeck, Stephan [Verfasser]. "Vergleichende Untersuchung von Desfluran und Propofol in equipotenten Dosierungen in Kombination mit Dexmedetomidin hinsichtlich zentraler Kreislaufparameter und der peripheren Perfusion und Oxygenierung beim Pferd / Stephan Neudeck." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2016. http://d-nb.info/112539501X/34.
Full textBeck, Andreas [Verfasser], Markus [Gutachter] Lange, Rainer [Gutachter] Leyh, and Jan [Gutachter] Stumpner. "Die Rolle des mitochondrialen Kalzium-abhängigen Kalium-Kanals mit großer Leitfähigkeit bei der Desfluran-induzierten Postkonditionierung / Andreas Erich Beck. Gutachter: Markus Lange ; Rainer Leyh ; Jan Stumpner." Würzburg : Universität Würzburg, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-102897.
Full textOshiro, Alexandre Hideaki. "Avaliação da variação de pressão de pulso (VPP) frente a diferentes concentrações inaladas de isoflurano, desflurano e sevoflurano: modelo experimental em suínos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-27032013-111704/.
Full textBackground: Inhalant anesthetics, such as isoflurane, sevoflurane and desflurane are widely used in daily clinical practice due to its pharmacological properties allowing a rapid recovery from anesthesia. Nevertheless, its use can lead to dose-dependent hemodynamic instability related to direct depression in myocardial contractility or to a relative hypovolemia caused by vasodilation of peripheral capillary bed. This study aims to evaluate the behavior of PPV during inhalant anesthesia. For this, three different anesthetics were used (isoflurane, sevoflurane and desflurane) with different inhaled concentrations. Methods: 25 young pigs were randomly assigned into three groups. Animals were anesthetized with its correspondent agent according to its group. After individual determination of minimal alveolar concentration (MAC), first data collection occurred. Pigs were then exposed to different MAC (1MAC and 1,25 MAC) followed by a decrease in MAC (1 MAC). At this point a 30% of estimated volemia hemorrhage was caused and pigs were exposed to a period of 1 MAC and after that 1,25 MAC. Each period lasted 20 minutes. At the end of each period, hemodynamic parameters and echocardiography were collected. Data were submitted to analysis of variance for repeated measures (ANOVA). P<0,05 was considered statistically significant. Results: There was an increase in PPV when with 1,25 MAC of all anesthetics. (from 8±1 to 11±3% in group DESF, from 7±2 to 9±2 in group SEVO and from 9±4 to 10±3% in group ISO), but without statistical difference among groups. Although there was an increase in PPV, followed by hypotension and drop in cardiac index, patients werent fluid responsive with a 25% increase in MAC, since PPV was lower than 13%. The decrease in blood pressure followed by 1,25MAC was only significant in DESF group (from 84±7 to 68±12 mmHg). No important alterations related to myocardial contractility were observed. Conclusion: PPV is not influenced by the use of different inhalant anesthetics and although there are cardiovascular effects of these agents which are expected, and were able to demonstrate alterations in preload even in concentration of 1,25 MAC
Nauleau, Pascale. "Utilisation d'un nouvel agent anesthésique halogène (desflurane) pour l'anesthésie de longue durée - Evaluation du réveil précoce." Bordeaux 2, 1996. http://www.theses.fr/1996BOR23077.
Full textArruda, Nayara Micarelli de. "Comparação de marcadores inflamatórios em pacientes cirúrgicos sob anestesia com desflurano ou desflurano associado ao óxido nitroso." Botucatu, 2018. http://hdl.handle.net/11449/154481.
Full textResumo: O presente estudo teve como objetivo comparar diversos marcadores inflamatórios e neuro-endócrinos em pacientes submetidos ao ato cirúrgico sob anestesia mantida com o halogenado desflurano ou desflurano associado ao gás óxido nitroso (N2O). Adicionalmente, realizou-se a comparação entre os momentos do estudo em cada grupo analisado em relação ao perfil neuro-imune-endócrino. Este estudo clínico prospectivo foi realizado em indivíduos adultos sem comorbidades, de ambos os sexos, que foram submetidos a cirurgia de septoplastia sob anestesia com desflurano ou desflurano associado ao N2O 60%. Amostras de sangue venoso foram coletadas em três momentos: antes da medicação pré-anestésica na sala de operação (basal), aos 90 minutos após a indução anestésica e no dia posterior ao ato cirúrgico. As citocinas inflamatórias interleucina (IL)-1β, -6, -8, -10, -17A e o fator de necrose tumoral (TNF)-α foram analisados por citometria de fluxo e a proteína C-reativa de alta sensibilidade (PCR-as) foi analisada por imunoensaio quimioluminescente. A expressão dos genes IL-6, ciclooxigenase-2 (COX-2) e fator de transcrição nuclear kappa-B (NF-kB), relacionados à inflamação, foi avaliada por reação em cadeia da polimerase em tempo real. Os hormônios adrenocorticotrófico (ACTH), cortisol e prolactina foram detectados por ensaio imunoenzimático quimioluminescente. Os dois grupos não diferiram quanto aos dados demográficos, intraoperatórios e neuro-imune-endócrinos. Houve aumento de prolactina no ... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The current study aimed to compare several of inflammatory and neuro-endocrine markers in surgical patients with anesthesia maintained with the halogenated desflurane or desflurane associated with the nitrous oxide (N2O) gas. In addition, the study compared the neuro-immune-endocrine profile among the time points in each studied group. This prospective clinical trial was conducted in adults with no comorbidities, of both sexes, who underwent septoplasty with desflurane or desflurane asnesthesia associated with N2O 60%. Blood samples were collected at three time points: before the patient received preanesthetic medication in the operating room (baseline), 90 minutes after anesthesia induction and the day after surgery. The inflammatory cytokines interleukin (IL)-1β, -6, -8, -10, -17A and tumor necrosis factor (TNF)-α were analyzed by flow cytometry, and high-sensitivity C-reactive protein (hs-CRP) was analyzed in the by chemiluminescent immunoassay. Inflammatory genes IL-6, cyclooxygenase-2 (COX-2) and nuclear factor - kappa B (NF-KB) were detected by quantitative polymerase chain reaction. The adrenocorticotrophic hormone (ACTH), cortisol and prolactin were detected by chemiluminescent immunoenzymatic assay. Both groups did not differ regarding demographic, intraoperative and neuro-immune-endocrine data. There were similar significant increases of intraoperative prolactin, and post-operative IL-6 and hs-CRP, in both groups. In conclusion, both anesthetic techniques did not di... (Complete abstract click electronic access below)
Mestre
Decorps, Anne. "Etude pharmacoéconomique en anesthésie : impact économique d'un réveil rapide après anesthésie au desflurane : étude coût-efficacité." Paris 5, 1999. http://www.theses.fr/1999PA05P156.
Full textYılmaz, Funda Ceylan Berit Gökçe. "Desfluranın antioksidan etkinliğinin propofol ile karşılaştırılması /." Isparta: SDÜ Tıp Fakültesi, 2006. http://tez.sdu.edu.tr/Tezler/TT00263.pdf.
Full textHaelewyn, Benoît. "Le desflurane, un médicament de l'anesthésie protecteur dans les ischémies cérébrale et cardiaque focales chez le rat in vivo." Caen, 2003. http://www.theses.fr/2003CAEN2058.
Full textScheepers, Pamela Anne. "A comparison of the potentiation by desflurane of the effects of rocoronium and cisatracurium." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85643.
Full textENGLISH ABSTRACT: Introduction: Of the volatile anaesthetic agents, desflurane causes the greatest degree of potentiation of the neuromuscular blocking drugs (NMB). The purpose of this study was to determine whether desflurane prolongs the effects of 3xED95 doses of rocuronium and cisatracurium to the same degree. The two NMB represent potent and less potent classes respectively. Methods: Informed, written consent was obtained from 63 adult patients scheduled for routine surgery. They were randomly allocated to one of four groups to receive either desflurane-sufentanil (end-tidal partial pressure 4.0 kPa) or propofol-sufentanil anaesthesia and either rocuronium (0.9mg/kg) or cisatracurium (0.15mg/kg). All patients received a target-controlled sufentanil infusion (0.5 ng/ml). Neuromuscular blockade was recorded using accelerometry (TOFGUARD ®, Organon) while patients recovered spontaneously to a Train-of-Four ratio of 0.9 (TOFR0.9). Data were analysed using one- and two-way analysis of variance. The main effects were the types of anaesthetic and NMB on indices of recovery. Results: Compared with propofol-sufentanil anaesthesia, mean times to recovery to T125% and TOFR0.9, were prolonged by desflurane-sufentanil (p<0.01). There were no interactions. Mean prolongation of time to TOFR0.9 was 41 min (SD 36) for cisatracurium and 26.6 min (SD 39) for rocuronium. Discussion: Whereas previous studies did not reveal prolongation of the duration of action of rocuronium by desflurane, we demonstrated a statistically significant prolongation of the spontaneous recovery times of both rocuronium and cisatracurium by desflurane. From the data we could not conclude that there was a difference between the two NMB. A power study revealed that in order to detect a difference between times to recovery to TOF0.9, a sample size of 101 subjects per group would be required. Conclusion: Desflurane prolongs the mean time to spontaneous recovery from neuromuscular blockade after 3xED95 doses of both cisatracurium (a potent NMB) and rocuronium (a less potent NMB). There was wide inter-individual variation in times to spontaneous recovery. Any difference in the mean prolongations between the different types of NMB is unlikely to be of clinical importance.
AFRIKAANSE OPSOMMING: Inleiding Van al die vlugtige narkosemiddels veroorsaak desfluraan die grootste mate van potensiasie van die neuromuskulêre blokkeermiddels. Die doel van hierdie studie was om vas te stel of desfluraan wel die effek van driedubbel die ED95 dosis van rokuronium en cisatrakurium tot dieselfde mate sal verleng. Metodiek Geskrewe ingeligte toestemming is verkry van 63 pasiënte wat voorgedoen het vir roetiene chirurgiese prosedures. Pasiënte is lukraak in een van vier groepe ingedeel om of desfluraansufentaniel (eind-gety parsieële druk 4.0 kPa) of propofol-sufentaniel narkose en of rokuronium (0.9 mg/kg) of cisatrakurium (0.15 mg/kg) te ontvang. Alle pasiënte het 'n teiken-beheerde sufentaniel infusie (0.5 ng/ml). Neuromuskulêre blokkade is waargeneem met behulp van aksellerometrie (TOF-GUARD, Organon) terwyl pasiënte spontaan herstel het tot “reeks-van-vier” verhouding (Engels “Train-of-four” ratio) 0.9 (TOFR0.9). Data analise is gedoen met behulp van een- en tweerigting analise van variansie. Resultate Desfluraan-sufentaniel het die gemiddelde hersteltyd tot T125% en TOFR0.9 verleng in vergelyking met propofol-sufentaniel. Geen interaksies is waargeneem nie. Gemiddelde verlenging van TOFR0.9 vir cisatrakurium was 41 minute (standaardafwyking 36) en vir rokuronium 26.6 minute (standaardafwyking 39). Bespreking Vorige studies kon nie vasstel of desfluraan die werkingsduur van rokuronium verleng nie. Ons het in hierdie studie vasgestel dat desfluraan wel 'n statisties beduidende verlenging in die hersteltyd van beide rokuronium en cisatrakurium veroorsaak. Ons kon egter nie 'n verskil tussen die twee neuromuskulêre agente aandui nie. 'n onderskeidingsvermoëstudie het getoon dat ten minste 101 pasiënte per groep benodig sou word om 'n beduidende verskil tussen die hersteltye tot TOFR0.9 te verkry. Gevolgtrekking Desfluraan verleng die gemiddelde hersteltyd tot spontane herstel van neuromuskulêre blokkade na driedubbele ED95 dosisse van beide cisatrakurium en rokuronium. Daar was egter groot interindividuele variasie ten opsigte van spontane hersteltyd. Enige verskille in die gemiddelde verlenging is onwaarskynlik van kliniese belang.
Lemoine, Sandrine. "Mécanismes impliqués dans le postconditionnement du myocarde humain induit par le desflurane, in vitro." Caen, 2008. http://www.theses.fr/2008CAEN2068.
Full textWe studied mechanisms involved in the effects of desflurane induced postconditioning on contractile properties of human myocardium, in vitro, submitted to a sequence of hypoxia-reoxygenation. First, our results show that brief exposure to desflurane, in early reoxygenation, preserved human myocardium contractility against hypoxia-reoxygenation, in vitro. Desflurane-induced postconditioning in human myocardium was mediated by: 1) Protein Kinase C activation, 2) mitochondrial KATP channel opening, 3) activation and phosphorylation of p38 MAPK, 4) adenosine receptors and bradykinin B2 receptors stimulation, 5) generation of radical oxygen species, 6) recruitment and activation of "Reperfusion Injury Salvage Kinases" pathway, 7) inhibition of mitochondrial transition permeability mPTP. Additionally, Protein Kinase C activation is upstream of mitochondrial KATP channel opening, p38 MAPK acts on Protein Kinase C in pathway signaling of postconditioning. We secondly reported that, brief administration of desflurane in early reoxygenation induced postconditioning in human diabetic (type 1 and 2 diabetes mellitus) myocardium, in vitro. These results suggest that desflurane could be used in clinical practice as a cardioprotector agent for diabetic patients
LaLande, Carla. "Comparison of Emergence Behavior in Pediatric Dental Patients Undergoing General Anesthesia with Sevoflurane versus Desflurane." VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/940.
Full textSantos, Paulo Sergio Patto dos [UNESP]. "Efeitos hemodinâmicos, eletrocardiográficos e hemogasométricos do butorfanol em cães anestesiados pelo desfluorano." Universidade Estadual Paulista (UNESP), 2003. http://hdl.handle.net/11449/101149.
Full textFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Avaliaram-se os efeitos hemodinâmicos, eletrocardiográficos e hemogasométricos decorrentes da aplicação do butorfanol em cães anestesiados pelo desfluorano. Utilizaram-se vinte cães adultos, machos e fêmeas, clinicamente saudáveis separados igualmente em dois grupos GP e GB e induzidos à anestesia com propofol, por via intravenosa, na dose de 8,4 l 0,8 mg/kg. Após a intubação com sonda orotraqueal de Magill, manteve-se a anestesia inalatória com desfluorano (10V%), diluído em O2 puro (30 mL/kg/min), através de circuito anestésico tipo semi fechado. Decorridos 40 minutos do início da anestesia inalatória foram administrados 0,05 mL/kg de solução de cloreto de sódio a 0,9% (placebo) ou 0,4 mg/kg de butorfanol, ambos por via intramuscular, respectivamente, aos animais do GP e GB. Considerou-se o período imediatamente anterior a estas aplicações como o momento zero (M0) para o registro dos parâmetros. Novas mensurações foram realizadas 15 minutos após (M15) e subseqüentemente a intervalos de 15 minutos, por um período de 60 minutos (M30, M45, M60 e M75). Os dados numéricos obtidos foram submetidos à Análise de Perfil, sendo considerado o nível de significância de p£0,05. A administração do butorfanol reduziu a freqüência cardíaca (FC), pressões arteriais sistólica (PAS), diastólica (PAD) e média (PAM), pressão média da artéria pulmonar (PAPm), resistência periférica total (RPT) e pressão de perfusão coronariana (PPC) ao longo de todo o período experimental. A pressão média do átrio direito (PADm) diminuiu em M30, M45 e M75 no GB quando comparado ao GP. O trabalho ventricular esquerdo (TVE) e índice do trabalho ventricular esquerdo (ITVE) diminuíram somente aos 15 minutos após a administração do opióide. Os intervalos RR e QT apresentaram valores de M0 menor que os demais no GB... .
The aim of this work was to evaluate alterations due to butorphanol administration in desflurane anesthetized dogs over hemodynamic, electrocardiography and blood gas analysis. Twenty adult dogs, males and females, clinically healthy, weighing 12l3 kg were used for this purpose. The dogs were separated in two groups (GP and GB) and general anesthesia was induced by intravenous administration of propofol (8.4l 0.8 mg/kg). All dogs were submitted to inhalatory anesthesia with desflurane (10V%), diluted in O2 (30 mL/kg/min), through a semi-closed anesthetic circuit. After 40 minutes of induction, animals from GP received saline solution at 0.9% (0.05 mL/kg) and from GB received butorphanol (0.4 mg/kg), both applied intramuscularly. Observations of the variables started immediately before the application of the agents (M0). Serial measurements were carried out in 15-minute intervals after the administration of butorphanol or saline up to 75 minutes, respectively M15, M30, M45, M60 and M75. Numeric data were submitted to profile analysis (p£0.05). Mean values for heart rate (HR), systolic (SAP), diastolic (DAP) and mean arterial pressure (MAP), mean pulmonary artery pressure (PAPm), total vascular resistance (TVR) and coronary perfusion pressure (CPP) were decreased after butorphanol administration. Mean right atrial pressure (RAPm) decreased at M30, M45 e M75 for GB when compared with GP and the left ventricular work (LVW) and left ventricular work index (LVWI) were significantly decreased 15 minutes after butorphanol administration. RR and QT intervals increased while the breathing rate (BR) decreased at M30. Mean values for PaCO2 and base deficit (BD) increased after butorphanol administration. Mean values for arterial pH were lower at M30, M45, M60 and M75 in GB when compared with GP and body temperature (T°C) gradually decreased for both groups... (Complete abstract, access undermentioned eletronic address)
Santos, Paulo Sergio Patto dos. "Efeitos hemodinâmicos, eletrocardiográficos e hemogasométricos do butorfanol em cães anestesiados pelo desfluorano /." Jaboticabal : [s.n.], 2003. http://hdl.handle.net/11449/101149.
Full textBanca: Carlos Augusto Araujo Valadão
Banca: Luiz Gonzaga Pompermayer
Banca: Silvia Renata Gaido Cortopassi
Banca: José Antonio Marques
Resumo: Avaliaram-se os efeitos hemodinâmicos, eletrocardiográficos e hemogasométricos decorrentes da aplicação do butorfanol em cães anestesiados pelo desfluorano. Utilizaram-se vinte cães adultos, machos e fêmeas, clinicamente saudáveis separados igualmente em dois grupos GP e GB e induzidos à anestesia com propofol, por via intravenosa, na dose de 8,4 l 0,8 mg/kg. Após a intubação com sonda orotraqueal de Magill, manteve-se a anestesia inalatória com desfluorano (10V%), diluído em O2 puro (30 mL/kg/min), através de circuito anestésico tipo "semi fechado". Decorridos 40 minutos do início da anestesia inalatória foram administrados 0,05 mL/kg de solução de cloreto de sódio a 0,9% (placebo) ou 0,4 mg/kg de butorfanol, ambos por via intramuscular, respectivamente, aos animais do GP e GB. Considerou-se o período imediatamente anterior a estas aplicações como o momento zero (M0) para o registro dos parâmetros. Novas mensurações foram realizadas 15 minutos após (M15) e subseqüentemente a intervalos de 15 minutos, por um período de 60 minutos (M30, M45, M60 e M75). Os dados numéricos obtidos foram submetidos à Análise de Perfil, sendo considerado o nível de significância de p£0,05. A administração do butorfanol reduziu a freqüência cardíaca (FC), pressões arteriais sistólica (PAS), diastólica (PAD) e média (PAM), pressão média da artéria pulmonar (PAPm), resistência periférica total (RPT) e pressão de perfusão coronariana (PPC) ao longo de todo o período experimental. A pressão média do átrio direito (PADm) diminuiu em M30, M45 e M75 no GB quando comparado ao GP. O trabalho ventricular esquerdo (TVE) e índice do trabalho ventricular esquerdo (ITVE) diminuíram somente aos 15 minutos após a administração do opióide. Os intervalos RR e QT apresentaram valores de M0 menor que os demais no GB... (Resumo completo, clicar acesso eletrônico abaixo).
Abstract: The aim of this work was to evaluate alterations due to butorphanol administration in desflurane anesthetized dogs over hemodynamic, electrocardiography and blood gas analysis. Twenty adult dogs, males and females, clinically healthy, weighing 12l3 kg were used for this purpose. The dogs were separated in two groups (GP and GB) and general anesthesia was induced by intravenous administration of propofol (8.4l 0.8 mg/kg). All dogs were submitted to inhalatory anesthesia with desflurane (10V%), diluted in O2 (30 mL/kg/min), through a semi-closed anesthetic circuit. After 40 minutes of induction, animals from GP received saline solution at 0.9% (0.05 mL/kg) and from GB received butorphanol (0.4 mg/kg), both applied intramuscularly. Observations of the variables started immediately before the application of the agents (M0). Serial measurements were carried out in 15-minute intervals after the administration of butorphanol or saline up to 75 minutes, respectively M15, M30, M45, M60 and M75. Numeric data were submitted to profile analysis (p£0.05). Mean values for heart rate (HR), systolic (SAP), diastolic (DAP) and mean arterial pressure (MAP), mean pulmonary artery pressure (PAPm), total vascular resistance (TVR) and coronary perfusion pressure (CPP) were decreased after butorphanol administration. Mean right atrial pressure (RAPm) decreased at M30, M45 e M75 for GB when compared with GP and the left ventricular work (LVW) and left ventricular work index (LVWI) were significantly decreased 15 minutes after butorphanol administration. RR and QT intervals increased while the breathing rate (BR) decreased at M30. Mean values for PaCO2 and base deficit (BD) increased after butorphanol administration. Mean values for arterial pH were lower at M30, M45, M60 and M75 in GB when compared with GP and body temperature (T°C) gradually decreased for both groups... (Complete abstract, access undermentioned eletronic address)
Doutor
Rezende, Márlis Langenegger de [UNESP]. "Efeitos do sevofluorano e do desfluorano sobre variáveis intracranianas e hemodinâmicas em cães." Universidade Estadual Paulista (UNESP), 2004. http://hdl.handle.net/11449/101136.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Avaliaram-se, comparativamente, os efeitos do sevofluorano e do desfluorano sobre variáveis intracranianas e hemodinâmicas em cães mantidos sob ventilação controlada. Foram utilizados 18 animais adultos, distribuidos aleatoreamente em dois grupos de igual número (GSEVO e GDES). Em todos os animais, induziu-se a anestesia geral com propofol (7,8l1,3 mg/kg/IV). Os cães foram intubados e a sonda orotraqueal foi acoplada a aparelho de anestesia inalatória. Em seguida, administrou-se a dose inicial de rocurônio (0,6 mg/kg/IV) e ato contínuo, iniciou-se a infusão contínua do miorrelaxante (0,6 mg/kg/h), a qual foi mantida durante todo o período experimental. Procedeu-se a ventilação controlada, com amplitude e freqüência suficientes para manter a capnometria constante em 35mmHg. Aos animais do GSEVO foi fornecido sevofluorano e aos animais do GDES, desfluorano, diluídos em O2. A anestesia inalatória foi mantida em 1,5 CAM (concentração alveolar mínima) para ambos os agentes voláteis. A administração do anestésico inalatório teve início imediatamente após a introdução da sonda orotraqueal. Foram estudadas as seguintes variáveis: pressão intracraniana (PIC), pressão de perfusão cerebral (PPC), temperatura intracraniana (TIC), freqüência cardíaca (FC), pressões arteriais sistólica (PAS), diastólica (PAD) e média (PAM), débito cardíaco (DC), índice cardíaco (IC), volume sistólico (VS), índice sistólico (IS), pressão venosa central (PVC), resistência vascular sistêmica (RVS), índice de resistência vascular sistêmica (IRVS) e temperatura corpórea (TC). As mensurações tiveram início após 30 minutos da implantação do cateter de PIC (M1) e se repetiram a cada 20 minutos (M2, M3 e M4). A avaliação estatística das variáveis foi efetuada pela Análise de Perfil (p<0,05)...
The aim of this study was to compare the effects of sevoflurane and desflurane upon intracranial and hemodynamic variables in dogs under controlled ventilation. Eighteen adult mongrel dogs were used. The animals were randomly allocated into 2 groups of equal number (GSEVO and GDES). All dogs were induced with propofol (7.8l1.3 mg/kg/IV), intubated, and the tracheal tube was connected to the inhalant anesthesia circuit. The neuromuscular blockade was acomplished by a bolus dose of rocuronium (0.6 mg/kg/IV) followed by continuous infusion of the agent (0.6 mg/kg/h) throughout the experimental period. Controlled ventilation was immediately started, with adequate amplitude and frequency to maintain end-tidal CO2 (ETCO2) constant at 35 mmHg. The animals of GSEVO received 1.5 MAC of sevoflurane and the ones in the GDES,1.5 MAC of desflurane, both agents diluted in O2. The administration of the inhalant agents started immediately after the placement of the tracheal tube.The following variables were studied: intracranial pressure (ICP), cerebral perfusion pressure (CPP), intracranial temperature (ICT), heart rate (HR), systolic (SAP), diastolic (DAP) and mean arterial pressures (MAP), cardiac output (CO), cardiac index (CI), stroke volume (SV), stroke index (SI), central venous pressure (CVP), systemic vascular resistance (SVR), systemic vascular resistance index (SVRI) and body temperature (BT). The measurements started 30 minutes after the placement of the ICP catheter (T1) and were repeated at 20 minutes intervals (T2, T3 and T4). The numerical data was submmited to Profile Analysis (p<0.05). ICP and CPP did not differ between GSEVO and GDES, while TIC and BT decreased slowly during the experimental period in both groups... (Complete abstract, access undermentioned eletronic address)
Rezende, Márlis Langenegger de. "Efeitos do sevofluorano e do desfluorano sobre variáveis intracranianas e hemodinâmicas em cães /." Jaboticabal : [s.n.], 2004. http://hdl.handle.net/11449/101136.
Full textBanca: Wagner Luís Ferreira
Banca: Rosangela de Oliveira Alves
Banca: Antônio José de Araújo Aguiar
Banca: Valéia Nobre Leal de Souza Oliva
Resumo: Avaliaram-se, comparativamente, os efeitos do sevofluorano e do desfluorano sobre variáveis intracranianas e hemodinâmicas em cães mantidos sob ventilação controlada. Foram utilizados 18 animais adultos, distribuidos aleatoreamente em dois grupos de igual número (GSEVO e GDES). Em todos os animais, induziu-se a anestesia geral com propofol (7,8l1,3 mg/kg/IV). Os cães foram intubados e a sonda orotraqueal foi acoplada a aparelho de anestesia inalatória. Em seguida, administrou-se a dose inicial de rocurônio (0,6 mg/kg/IV) e ato contínuo, iniciou-se a infusão contínua do miorrelaxante (0,6 mg/kg/h), a qual foi mantida durante todo o período experimental. Procedeu-se a ventilação controlada, com amplitude e freqüência suficientes para manter a capnometria constante em 35mmHg. Aos animais do GSEVO foi fornecido sevofluorano e aos animais do GDES, desfluorano, diluídos em O2. A anestesia inalatória foi mantida em 1,5 CAM (concentração alveolar mínima) para ambos os agentes voláteis. A administração do anestésico inalatório teve início imediatamente após a introdução da sonda orotraqueal. Foram estudadas as seguintes variáveis: pressão intracraniana (PIC), pressão de perfusão cerebral (PPC), temperatura intracraniana (TIC), freqüência cardíaca (FC), pressões arteriais sistólica (PAS), diastólica (PAD) e média (PAM), débito cardíaco (DC), índice cardíaco (IC), volume sistólico (VS), índice sistólico (IS), pressão venosa central (PVC), resistência vascular sistêmica (RVS), índice de resistência vascular sistêmica (IRVS) e temperatura corpórea (TC). As mensurações tiveram início após 30 minutos da implantação do cateter de PIC (M1) e se repetiram a cada 20 minutos (M2, M3 e M4). A avaliação estatística das variáveis foi efetuada pela Análise de Perfil (p<0,05)... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The aim of this study was to compare the effects of sevoflurane and desflurane upon intracranial and hemodynamic variables in dogs under controlled ventilation. Eighteen adult mongrel dogs were used. The animals were randomly allocated into 2 groups of equal number (GSEVO and GDES). All dogs were induced with propofol (7.8l1.3 mg/kg/IV), intubated, and the tracheal tube was connected to the inhalant anesthesia circuit. The neuromuscular blockade was acomplished by a bolus dose of rocuronium (0.6 mg/kg/IV) followed by continuous infusion of the agent (0.6 mg/kg/h) throughout the experimental period. Controlled ventilation was immediately started, with adequate amplitude and frequency to maintain end-tidal CO2 (ETCO2) constant at 35 mmHg. The animals of GSEVO received 1.5 MAC of sevoflurane and the ones in the GDES,1.5 MAC of desflurane, both agents diluted in O2. The administration of the inhalant agents started immediately after the placement of the tracheal tube.The following variables were studied: intracranial pressure (ICP), cerebral perfusion pressure (CPP), intracranial temperature (ICT), heart rate (HR), systolic (SAP), diastolic (DAP) and mean arterial pressures (MAP), cardiac output (CO), cardiac index (CI), stroke volume (SV), stroke index (SI), central venous pressure (CVP), systemic vascular resistance (SVR), systemic vascular resistance index (SVRI) and body temperature (BT). The measurements started 30 minutes after the placement of the ICP catheter (T1) and were repeated at 20 minutes intervals (T2, T3 and T4). The numerical data was submmited to Profile Analysis (p<0.05). ICP and CPP did not differ between GSEVO and GDES, while TIC and BT decreased slowly during the experimental period in both groups... (Complete abstract, access undermentioned eletronic address)
Doutor
Alterovitz, Gil 1975. "Temporal characterization of patient state with applications to prediction of tachycardia in anesthesia via induction of inhaled desflurane." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/35281.
Full textThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Includes bibliographical references (leaves 64-65).
It has always been assumed that using clinically measurable parameters is the most efficient way to characterize patient state. By adding additional sensors, monitors, and derived statistics (e.g. mean arterial blood pressure from diastolic and systolic), it was hoped that more information could be garnered about patient state. This thesis challenges the assumption that providing the physician with a full set of clinically measurable parameters is the most efficient way to characterize patient state. The thesis presents a novel way to consider patient state by utilizing reduced dimensionality and by estimating noise. It then explores an application, namely prediction of tachycardia, which often occurs at the onset of induction of inhaled desflurane. One unexpected initial finding was that all 46 patients exhibited tachycardia or hypertension within the first hour of the operation. Three models for predicting tachycardia episodes are proposed, including one model based on use of Blind Noise Adjusted Principal Component Analysis1 (using Iterative Order and Noise Estimate (ION)2 and Principal Component Analysis (PCA)3). Without ION, PCA-based methods alone yielded only 2 useful degrees of freedom, with the rest being relegated to noise. The ION PCA-based method allows one to capture with 5 principal components the information contained in 31 fundamental and derived patient variables, while at the same time reducing the effects of noise. Furthermore, the five discovered significant principal components representing patient state were characterized quantitatively and their physiologic correlates are hypothesized qualitatively. Examination of the 31 original patient parameters in the ION PCA model that predicts tachycardia revealed the relative importance of the original patient parameters to the tachycardia problem. The receiver operating characteristic (ROC) curve for the ION PCA-based predictor suggested a 70% detection rate with 3% false alarms when predicting tachycardia two minutes and twenty seconds into the future. While the patient state characterization method was used for tachycardia prediction, it is potentially useful in myriad medical domains involving multivariate analysis.
by Gil Alterovitz.
S.M.
Nogueira, Flávia Ribeiro [UNESP]. "A anestesia inalatória com desflurano associada ou não ao óxido nitroso é genotóxica e induz estresse oxidativo em pacientes?" Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/149819.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O presente estudo teve como objetivo avaliar os possíveis efeitos genotóxicos e de estresse oxidativo do anestésico inalatório halogenado desflurano, associado ou não ao gás óxido nitroso (N2O). O estudo foi realizado em 40 indivíduos, de ambos os sexos, com estado físico classificado pelo American Society of Anesthesiologists (ASA) I, com idade de 18 a 50 anos. Os pacientes foram aleatoriamente alocados em dois grupos de 20, sob desflurano (6%) ou desflurano com N2O (60%) e foram submetidos a cirurgia minimamente invasiva (septoplastia) com duração mínima de 90 minutos. Amostras sanguíneas foram coletadas antes dos pacientes receberem medicação pré-anestésica (M0-controle), aos 90 minutos após o início da anestesia inalatória (M1) e na manhã do dia posterior ao ato anestésico-cirúrgico (M2). Os danos basais e oxidativos no ácido desoxirribonucleico (DNA) foram avaliados pelo teste do cometa; o estresse oxidativo foi avaliado por marcadores de peroxidação lipídica como malonaldeído (MDA) pelo método de High Performance Liquid Chromatography (HPLC), 4-hidroxinonenal (4-HNE) e 8-isoprostano pelo método de imunoensaio; a oxidação proteica foi avaliada por proteínas carboniladas por imunoensaio e o teste de defesa antioxidante plasmática analisado por fluorometria e pelo Ferric Reducing Antioxidant Power (FRAP), por espectrofotometria. Não houve diferença significante em relação os dados demográficos, tempo de cirurgia ou doses dos fármacos administrados entre os grupos. Os resultados de genotoxicidade, estresse oxidativo e da capacidade antioxidante não diferiram estatisticamente entre os dois grupos. Entretanto, na manhã do dia posterior ao ato anestésico-cirúrgico, a anestesia mantida com desflurano mostrou aumento de danos no DNA (p = 0,01) e peroxidação lipídica por 4-HNE (p = 0,03). Por outro lado, os marcadores de danos oxidativos no DNA, peroxidação lipídica (MDA e 8-isoprostano), proteínas carboniladas e FRAP não se alteraram nos grupos desflurano e desflurano/N2O (p > 0,05). Dessa forma, o N2O não intensificou os efeitos genotóxicos nem de estresse oxidativo do halogenado desflurano, revelando ser técnica anestésica segura em indivíduos hígidos submetidos a cirurgia minimamente invasiva com duração mínima de 90 minutos.
The current study aimed to evaluate the possible genotoxic and oxidative stress effects of the inhalational halogenated anesthetic desflurane, associated or not with nitrous oxide (N2O). The study was conducted in 40 patients of both sexes, with physical status classified by the American Society of Anesthesiologists (ASA) I, aged 18 to 50 years. Patients who underwent minimally invasive surgery (septoplasty) lasting at least 90 minutes were randomly allocated into two groups of 20 under desflurane (6%) or desflurane with N2O (60%). Blood samples were collected before the patient received the pre-anesthetic medication (T0-baseline), 90 minutes after the beggining of inhalation anesthesia (T1) and on the morning of the postoperative first day (T2). The basal and oxidative damages in deoxyribonucleic acid (DNA) were evaluated by the comet assay; oxidative stress was evaluated by lipoperoxidation markers as malonaldehyde (MDA) assessed by High Performance Liquid Chromatography (HPLC), 4-hydroxynonenal (4-HNE) and 8-iso-prostaglandin F2 (8-isoprostane) by immunoassay; for protein oxidation, the carbonylated proteins were evaluated by immunoassay, and plasma antioxidant defense was analyzed by fluorometry and also by the Ferric Reducing Antioxidant Power (FRAP), detected by spectrophotometry. There were no significant differences between the groups regarding demographic data, time of surgery or doses of the drugs administered. The results of genotoxicity, oxidative stress and antioxidant capacity did not differ statistically between both groups. However, on the morning of the postoperative first day, anesthesia with desflurane showed increase of DNA damage (p = 0.01) and lipid peroxidation by 4-HNE (p = 0.03). On the other hand, markers of oxidative damage in DNA, lipid peroxidation (MDA and 8-isoprostane), protein carbonyl, and FRAP changed neither in the desflurane nor in the desflurane/N2O group (p > 0.05). Thus, N2O did not intensify genotoxic and oxidative stress effects of the halogenated desflurane, proving to be a safe anesthetic technique in healthy individuals who undergo minimally invasive surgery lasting at least 90 minutes.
CNPq: 130298/2014-0
FAPESP: 13/16842-0
Nogueira, Flávia Ribeiro. "A anestesia inalatória com desflurano associada ou não ao óxido nitroso é genotóxica e induz estresse oxidativo em pacientes?" Botucatu, 2017. http://hdl.handle.net/11449/149819.
Full textResumo: O presente estudo teve como objetivo avaliar os possíveis efeitos genotóxicos e de estresse oxidativo do anestésico inalatório halogenado desflurano, associado ou não ao gás óxido nitroso (N2O). O estudo foi realizado em 40 indivíduos, de ambos os sexos, com estado físico classificado pelo American Society of Anesthesiologists (ASA) I, com idade de 18 a 50 anos. Os pacientes foram aleatoriamente alocados em dois grupos de 20, sob desflurano (6%) ou desflurano com N2O (60%) e foram submetidos a cirurgia minimamente invasiva (septoplastia) com duração mínima de 90 minutos. Amostras sanguíneas foram coletadas antes dos pacientes receberem medicação pré-anestésica (M0-controle), aos 90 minutos após o início da anestesia inalatória (M1) e na manhã do dia posterior ao ato anestésico-cirúrgico (M2). Os danos basais e oxidativos no ácido desoxirribonucleico (DNA) foram avaliados pelo teste do cometa; o estresse oxidativo foi avaliado por marcadores de peroxidação lipídica como malonaldeído (MDA) pelo método de High Performance Liquid Chromatography (HPLC), 4-hidroxinonenal (4-HNE) e 8-isoprostano pelo método de imunoensaio; a oxidação proteica foi avaliada por proteínas carboniladas por imunoensaio e o teste de defesa antioxidante plasmática analisado por fluorometria e pelo Ferric Reducing Antioxidant Power (FRAP), por espectrofotometria. Não houve diferença significante em relação os dados demográficos, tempo de cirurgia ou doses dos fármacos administrados entre os grupos. Os resul... (Resumo completo, clicar acesso eletrônico abaixo)
Doutor
Kretzschmar, Moritz Andreas. "Ventilation/Perfusion Matching and its Effect on Volatile Pharmacokinetics." Doctoral thesis, Uppsala universitet, Hedenstiernalaboratoriet, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-304298.
Full textGueugniaud, Pierre-Yves. "Contractilité myocardique et agents anesthésiques halogénés : de l'étude expérimentale in vitro à l'approche clinique par débitmétrie aortique écho-Doppler." Lyon 1, 1998. http://www.theses.fr/1998LYO1T221.
Full textNavarro, Mantari Angel Marcial. "Despertar en la anestesia con remifentanilo en asociación con desfluorane o isofluorane para cirugía oncológica de mama : Instituto Nacional de Enfermedades Neoplásicas 2009." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2009. https://hdl.handle.net/20.500.12672/15296.
Full textCompara el despertar en la anestesia con Remifentanilo en asociación con Desfluorane o Isofluorane para cirugía oncológica de mama. Es un estudio observacional, transversal, comparativo y prospectivo. La edad promedio es semejante en ambos grupos. El tiempo anestésico es mayor en el grupo que recibió anestesia con Desfluorane y Remifentanilo. El grupo etáreo en ambos grupos fue el de 46 a 55 años de edad. El diagnóstico más frecuente en ambos grupos es el Cáncer de mama derecha. Se empleó mayor tiempo anestésico en el grupo 2 (Desfluorane y Remifentanilo). La velocidad de infusión de Remifentanilo es mayor en el grupo 2 (Desfluorane y Remifentanilo) que el grupo 1 (Isofluorane y Remifentanilo). El consumo de Remifentanilo es mayor en el grupo 2 (Desfluorane y Remifentanilo) comparado con el grupo 1 (Isofluorane y Remifentanilo). El tiempo de despertar de los pacientes es menor en el grupo 2 (Desfluorane y Remifentanilo) comparado con el grupo 1 (Isofluorane y Remifentanilo). Existe una correlación negativa entre el tiempo anestésico y tiempo de despertar quiere decir a mayor tiempo anestésico menor tiempo de despertar. La escala de sedación en ambos grupos fue Ramsay 2 para el grupo 1 y grupo 2, es decir el paciente se encuentra despierto, tranquilo, orientado y colaborador. Se concluye que el despertar fue menor en el tiempo e igual en calidad en el grupo de desfluorane que isofluorane.
Trabajo académico
Schilling, Thomas. "The Immune Response to One-Lung Ventilation Clinical and Experimental Studies /." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108851.
Full textFlack, Larry A. "Nurse exposure to waste anesthetic gases in a post anesthesia care unit." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001579.
Full textSchaarschmidt, Christina [Verfasser]. "Vergleichende Untersuchungen zum Aufwachverhalten nach Anästhesie mit Xenon-Desfluran oder Lachgas-Desfluran bei Eingriffen an der unteren Extremität / Christina Schaarschmidt." 2003. http://d-nb.info/967532264/34.
Full textLohmann, Susanne [Verfasser]. "Verträglichkeit, Nebenwirkungen und Hämodynamik der inhalativen Sedierung mit Desfluran im Rahmen der Studie: Desfluran versus Propofol zur Sedierung beatmeter Patienten / vorgelegt von Susanne Lohmann." 2006. http://d-nb.info/980311594/34.
Full textStumpner, Jan. "Desfluran induziert ein erstes und ein zweites Fenster der Präkonditionierung gegen Myokardinfarkt in vivo." Doctoral thesis, 2007. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-27263.
Full textThe phenomenon of ischemic preconditioning (IPC) describes an endogenous protective mechanism resulting in increased tolerance of tissues against ischemia. Volatile anesthetics are able to activate this mechanism of preconditioning. Ischemic preconditioning shows a characteristic biphasic time course consisting of an early first and a delayed second window of preconditioning separated by a period without cardioprotective effects. The aim of the current study was to investigate wether desflurane-induced preconditioning exhibits a biphasic time pattern similar to IPC, and to characterize the role of nitric oxide (NO) in this process. For this purpose we used an in vivo rabbit model of acute myocardial infarction. Desflurane induced a first window of preconditioning which lasted up to two hours after the cessation of the volatile anesthetic. Furthermore, desflurane induced a second window of preconditioning, which was detectable after 24 hours and lasted up to 72 hours after administration of the volatile anesthetic. Both windows of protection were separated by a period without any cardioprotective effect. No cardioprotection was detectable 96 hours after cessation of desflurane. To determine the role of NO in the second window of preconditioning we administered the NO-synthase inhibitor L-omega-nitro-arginine (LNA) prior to coronary artery occlusion. Our results demonstrate that desflurane-induced preconditioning against myocardial infarction in vivo exhibits a characteristic biphasic time pattern similar to ischemic preconditioning. In addition, we demonstrated that endogenous NO is a mediator of the second window of desflurane-induced preconditioning