Relevant bibliographies by topics / Design à base de fragments

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Design à base de fragments'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "Design à base de fragments"

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Nair, Pramod C., Alpeshkumar K. Malde, Nyssa Drinkwater, and Alan E. Mark. "Missing Fragments: Detecting Cooperative Binding in Fragment-Based Drug Design." ACS Medicinal Chemistry Letters 3, no. 4 (2012): 322–26. http://dx.doi.org/10.1021/ml300015u.

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Zhang, Sixue, Atefeh Garzan, Nicole Haese, et al. "Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design." PLOS ONE 16, no. 1 (2021): e0245013. http://dx.doi.org/10.1371/journal.pone.0245013.

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The macrodomain of nsP3 (nsP3MD) is highly conserved among the alphaviruses and ADP-ribosylhydrolase activity of Chikungunya Virus (CHIKV) nsP3MD is critical for CHIKV viral replication and virulence. No small molecule drugs targeting CHIKV nsP3 have been identified to date. Here we report small fragments that bind to nsP3MD which were discovered by virtually screening a fragment library and X-ray crystallography. These identified fragments share a similar scaffold, 2-pyrimidone-4-carboxylic acid, and are specifically bound to the ADP-ribose binding site of nsP3MD. Among the fragments, 2-oxo-5
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Kashyap, Aanchal, Pankaj Kumar Singh, and Om Silakari. "Counting on Fragment Based Drug Design Approach for Drug Discovery." Current Topics in Medicinal Chemistry 18, no. 27 (2019): 2284–93. http://dx.doi.org/10.2174/1568026619666181130134250.

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Fragment based drug design (FBDD) is a structure guided ligand design approach used in the process of drug discovery. It involves identification of low molecular weight fragments as hits followed by determination of their binding mode using X-ray crystallography and/or NMR spectroscopy. X-ray protein crystallography is one of the most sensitive biophysical methods used for screening and is least prone to false positives. It also provides detailed structural information of the protein–fragment complex at the atomic level. The retrieved binding information facilitates the optimization of fragmen
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Pidnebesna, Halyna A. "The Design of Inductive Modeling Tools Using Ontologies." Control Systems and Computers, no. 6 (290) (December 2020): 46–54. http://dx.doi.org/10.15407/csc.2020.06.046.

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The architecture of the GMDH-based inductive modeling tools is considered. A feature is the use of the knowledge base in the form of an ontology of the subject area of inductive modeling. The application of the ontological approach to the design of the knowledge base makes it possible to automatically acquire new knowledge, efficiently process information in the modeling of complex objects of different nature according to statistical data, generate queries and obtain logical inferences. Fragments of the GMDH-based inductive modeling ontology are given as an example of creating a formal descrip
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Li, Yong, Dong Chen, Ming Jiang, and Zonghao Tian. "Research on the Characteristic of Projectile Fragments Dispersion Based on Fragment Warhead Design." IOP Conference Series: Materials Science and Engineering 573 (August 2, 2019): 012104. http://dx.doi.org/10.1088/1757-899x/573/1/012104.

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Padilha, Ricardo, Jose Luiz Portugal, Adriano Vicente dos Santos, Sônia Valeria Pereira, and Tiago Vinícius Batista do Carmo. "Proposição de Modelo de Corredores Ecológicos com Base no Sistema de Informações Geográficas na Região de Suape, Pernambuco, Brasil (Propose a Model for Ecological Corridors Based on Geographic Information System in the Region of Suape, Pernambuco,...)." Revista Brasileira de Geografia Física 9, no. 1 (2016): 079. http://dx.doi.org/10.26848/rbgf.v9.1.p079-090.

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A expansão de áreas agrícolas e urbanas, a implementação de projetos industriais, entre outras atividades antrópicas, promovem a alteração da paisagem original, criando outra, dominada por vários remanescentes da vegetação nativa. Estes remanescentes, denominados também de fragmentos florestais, são fundamentais para manutenção da biodiversidade existente no local. Porém uma paisagem fragmentada torna os remanescentes florestais isolados vulneráveis, nesse sentido, torna-se importante a concepção de conexões para interligar os fragmentos, diminuindo a pressão sobre sua diversidade e aumentando
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Zahra, Sana Ali, Ayesha Imran, Faiza Khalid, and Mubashir Rehman. "Fragment-Based Approach towards the Design of Potent and Versatile Anti-Cancer Agents." Global Drug Design & Development Review V, no. I (2020): 1–14. http://dx.doi.org/10.31703/gdddr.2020(v-i).01.

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Despite years of clinical research and trials of encouraging new therapies, cancer remains a leading cause of morbidity and mortality. The fragment-based drug discovery has evolved formerly as an efficient approach for identification, optimization, and generation of lead. After identifying the fragments having binding affinity with the target using computational method for fragment screening, they are optimized into more active compounds. This review elaborates the application of methodology of fragment-based drug design in designing potent and versatile anti-cancer drug candidates. It compris
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Lee, Hyukzae, Jonghee Kim, Chanho Jung, Yongchan Park, Woong Park, and Jihong Son. "A Deep Learning-Based Fragment Detection Approach for the Arena Fragmentation Test." Applied Sciences 10, no. 14 (2020): 4744. http://dx.doi.org/10.3390/app10144744.

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The arena fragmentation test (AFT) is one of the tests used to design an effective warhead. Conventionally, complex and expensive measuring equipment is used for testing a warhead and measuring important factors such as the size, velocity, and the spatial distribution of fragments where the fragments penetrate steel target plates. In this paper, instead of using specific sensors and equipment, we proposed the use of a deep learning-based object detection algorithm to detect fragments in the AFT. To this end, we acquired many high-speed videos and built an AFT image dataset with bounding boxes
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Aguirre, Clémentine, Tim ten Brink, Jean-François Guichou, Olivier Cala, and Isabelle Krimm. "Comparing Binding Modes of Analogous Fragments Using NMR in Fragment-Based Drug Design: Application to PRDX5." PLoS ONE 9, no. 7 (2014): e102300. http://dx.doi.org/10.1371/journal.pone.0102300.

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Hidayat, Muhammad Fauzi, Eka Gunarti Ningsih, Ahmad Husein Alkaff та Usman Sumo Friend Tambunan. "Discovery of Novel α-Amylase Inhibitors as Type Two Diabetes Mellitus Therapy through Fragment-Based Drug Design". Key Engineering Materials 840 (квітень 2020): 237–44. http://dx.doi.org/10.4028/www.scientific.net/kem.840.237.

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Diabetes is one of the top causes of death in the world, with 425 million sufferers reported in 2017. About 90% of diabetics suffer from Type 2 Diabetes Mellitus (T2DM). Recent studies show that inhibiting the α-amylase enzyme can significantly decrease the postprandial blood glucose levels through blocking carbohydrate hydrolysis. Therefore, it can be a promising strategy for T2DM treatment. This research was aimed to find the new potential inhibitor for the α-amylase from lead-like compounds Molecular Operating Environment (MOE) database through fragment-based drug design, combining with str
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Dissertations / Theses on the topic "Design à base de fragments"

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Hoffer, Laurent. "Développement et validation du logiciel S4MPLE : application au docking moléculaire et à l'optimisation de fragments assistée par ordinateur dans le cadre du fragment-based drug design." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00874644.

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Cette thèse a pour but de développer le pendant in silico des étapes clés du Fragment-Based Drug Design (FBDD), et ce dans le cadre plus général du développement de l'outil S4MPLE. Le FBDD génère des ligands drug-like à partir de petites molécules (fragments). Après une étape de validation de S4MPLE et de sa fonction d'énergie, un recentrage autour du FBDD est réalisé, à travers le docking puis l'optimisation virtuelle de fragments par growing ou linking (G/L). Cette stratégie reposesur 1) la création d'une chimiothèque focalisée en connectant un ou deux fragment(s) avec des linkers pré-généré
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Barelier, Sarah. "Probing protein-small molecule interactions by Nuclear Magnetic Resonance : towards a better understanding of the Fragment-Based Drug Design methodology." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10222.

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La méthode de conception de médicaments à partir de molécules « fragments » (connue sous le nom de « Fragment-Based Drug Design ») a été proposée au milieu des années 90, et a depuis été reconnue comme une alternative tangible aux techniques plus classiques de recherche de médicaments telles que le criblage à haut débit par exemple. La méthode des fragments consiste à cribler un petit nombre (< 10000) de composés organiques de faible poids moléculaire (< 300 Da) afin de détecter ceux qui se lient à la cible (protéine ou acides nucléiques). Du fait de leur faible complexité, les fragments
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Rahimova, Rahila. "Structure-based drug design of allosteric ecto-5'-nucleotidase inhibitors : application to cancer treatment." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT039.

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Le cancer représente l'un des problèmes majeurs en santé publique. Jusqu'à présent, en parallèle de l'intervention chirurgical, plusieurs traitements ont été mis au point et largement utilisés en thérapie clinique telles que les chimiothérapies. Cependant, leur efficacité est parfois limitée et couplée à des effets secondaires très néfastes, laissant les patients dans une impasse thérapeutique. Par conséquent, de nouvelles approches thérapeutiques doivent être développées sur de nouvelles cibles avérées en oncologie afin d'apporter des soins personnalisés aux patients. La première partie de mo
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Lepron, Marco. "Conception de ligands allostériques du sous-type α5 des récepteurs nicotiniques à l'acétylcholine". Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS584.

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Les récepteurs nicotiniques à l’acétylcholine (nAChRs) sont des protéines transmembranaires appartenant à la superfamille des canaux ioniques pentamériques activés par des ligands (pLGICs). Impliqués dans la transmission et la modulation de l’influx nerveux, ils sont à ce jour des cibles thérapeutiques privilégiées pour le traitement de neuropathologies telles que la maladie d’Alzheimer, la schizophrénie ou encore l’addiction au tabac. Les nAChRs neuronaux les plus répandus sont les sous-types α7 (homomérique) et α4β2 (hétéromérique). La sous-population mineure des récepteurs α5(α4β2)2 contena
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Sartori, Geraldo Rodrigues. "Planejamento de inibidores baseado em fragmentos moleculares para a enzima gliceraldeído-3-fosfato desidrogenase de Trypanosoma cruzi." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-24072012-142746/.

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A Doença de Chagas, endêmica na América Latina, é causada pelo parasito tripanossomatídeo Trypanosoma cruzi e atualmente já se espalha para o restante do mundo devido à migração humana. Os dois medicamentos disponíveis para o tratamento dessa doença, o Nifurtimox, (banido do Brasil), e o Benzonidazol, são eficazes somente na etapa aguda da doença e possuem efeitos colaterais severos. Recentemente, três novas substâncias para o tratamento chegaram à fase clínica de testes contra essa doença, mas ainda é necessária a pesquisa de novas moléculas contra esse parasito. A enzima Gliceraldeído-3-fosf
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Villemagne, Baptiste. "Conception, synthèse et dévelopement d'inhibiteurs du répresseur transcriptionnel mycobactérien ETHR selon une approche par fragments. Une nouvelle approche dans la lutte contre la tuberculose." Thesis, Lille 2, 2012. http://www.theses.fr/2012LIL2S052/document.

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Avec plus d’un million et demi de morts chaque année, la tuberculose reste aujourd’hui la seconde cause de mortalité liée à un agent infectieux. De plus l’organisation mondiale de la santé (OMS) a estimé en 2011 qu’un tiers de la population mondiale était porteuse du bacille Mycobacterium tuberculosis responsable de la maladie. Depuis la fin des années 1980, une recrudescence du nombre de cas de tuberculose est observée à l’échelle mondiale. Cette recrudescence est due à la fois à l’apparition de souches résistantes, mais également à l’épidémie de VIH qui est un facteur de prédisposition au dé
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Hayes, Edward. "Fragment based design of cholera toxin inhibitors." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534749.

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Craan, Tobias Friedrich [Verfasser], and Gerhard [Akademischer Betreuer] Klebe. "Fragment based Drug Discovery : Design and Validation of a Fragment Library ; Computer-based Fragment Screening and Fragment-to-Lead Expansion / Tobias Friedrich Craan. Betreuer: Gerhard Klebe." Marburg : Philipps-Universität Marburg, 2011. http://d-nb.info/1013288807/34.

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Woodlock, David A. "Application of molecular mechanics polarization to fragment based drug design." Thesis, University of Essex, 2015. http://repository.essex.ac.uk/16774/.

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Polarization is a term that is often excluded from almost all virtual screening. Polarizability helps explain interactions between nonpolar atoms and electrically charged species. When studying fragments in FBDD these minor interactions could have large effect in changing how well a ligand will bind to its target. After including the polarizability terms in docking a validation set of ligands (Favia et al., 2011) with GLIDE, it improved the results the amount good docked poses (< 2 Å RMSD) by up to 12%. However some ligands were bound in incorrect poses. Further investigation was carried out w
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Venot, Pierre-Etienne. "Synthèse stéréosélective d'Hybrides de lobéline et de ligands naturels des récepteurs nicotiniques centraux à l’acétylcholine." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA114813/document.

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Au cours de ce travail, nous avons développé des voies de synthèses convergentes et énantiosélectives en vue de préparer des analogues pyrrolidiniques des alcaloïdes de Lobelia comme nouveaux ligands des récepteurs nicotiniques à l’acétylcholine. Deux familles de ligands ont été réalisées par des méthodes d’élongation mono- ou bi-directionnelle basées respectivement sur des stratégies de désymétrisation précoce ou tardive au départ du succinaldéhyde.La première partie de ce manuscrit aborde la conception d’hybrides de lobéline, nicotine et d’agonistes naturels. Ces structures originales ont ét
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Books on the topic "Design à base de fragments"

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Bienstock, Rachelle J. Library design, search methods, and applications of fragment-based drug design. American Chemical Society, 2011.

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Bienstock, Rachelle J., ed. Library Design, Search Methods, and Applications of Fragment-Based Drug Design. American Chemical Society, 2011. http://dx.doi.org/10.1021/bk-2011-1076.

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E, Jones Paul, ed. Logical data base design. 2nd ed. QED Information Sciences, 1988.

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Fragment-based drug discovery and X-ray crystallography. Springer, 2012.

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Salzberg, Betty Joan. Introduction to data base design. Academic Press, 1986.

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Koelle, H. H. Conceptual design of a lunar base. Shaker Verlag, 2004.

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Howe, D. R. Data analysis for data base design. 2nd ed. Edward Arnold, 1989.

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Effective design of CODASYL data base. Macmillan, 1985.

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Salzberg, Betty Joan. An introduction to data base design. Academic Press, 1986.

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Furtado, Antonio L., and Erich J. Neuhold. Formal Techniques for Data Base Design. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70592-2.

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Book chapters on the topic "Design à base de fragments"

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Mamouras, Konstantinos. "Semantic Foundations for Deterministic Dataflow and Stream Processing." In Programming Languages and Systems. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-44914-8_15.

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AbstractWe propose a denotational semantic framework for deterministic dataflow and stream processing that encompasses a variety of existing streaming models. Our proposal is based on the idea that data streams, stream transformations, and stream-processing programs should be classified using types. The type of a data stream is captured formally by a monoid, an algebraic structure with a distinguished binary operation and a unit. The elements of a monoid model the finite fragments of a stream, the binary operation represents the concatenation of stream fragments, and the unit is the empty fragment. Stream transformations are modeled using monotone functions on streams, which we call stream transductions. These functions can be implemented using abstract machines with a potentially infinite state space, which we call stream transducers. This abstract typed framework of stream transductions and transducers can be used to (1) verify the correctness of streaming computations, that is, that an implementation adheres to the desired behavior, (2) prove the soundness of optimizing transformations, e.g. for parallelization and distribution, and (3) inform the design of programming models and query languages for stream processing. In particular, we show that several useful combinators can be supported by the full class of stream transductions and transducers: serial composition, parallel composition, and feedback composition.
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Feyfant, Eric, Jason B. Cross, Kevin Paris, and Désirée H. H. Tsao. "Fragment-Based Drug Design." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-931-4_12.

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Bower, Justin, Angelo Pugliese, and Martin Drysdale. "Strategies for Fragment Library Design." In Fragment-based Drug Discovery Lessons and Outlook. Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527683604.ch05.

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Bienstock, Rachelle J. "Overview: Fragment-Based Drug Design." In Library Design, Search Methods, and Applications of Fragment-Based Drug Design. American Chemical Society, 2011. http://dx.doi.org/10.1021/bk-2011-1076.ch001.

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Sheng, Chunquan, Guoqiang Dong, and Chen Wang. "Computational Fragment-Based Drug Design." In Methods in Pharmacology and Toxicology. Springer New York, 2015. http://dx.doi.org/10.1007/7653_2015_51.

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Krimm, Isabelle. "CHAPTER 3. Applications of NMR in Fragment-Based Drug Design." In Fragment-Based Drug Discovery. Royal Society of Chemistry, 2015. http://dx.doi.org/10.1039/9781782620938-00049.

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Zsoldos, Zsolt. "A Fragment-Based Docking Engine: eHiTS." In Library Design, Search Methods, and Applications of Fragment-Based Drug Design. American Chemical Society, 2011. http://dx.doi.org/10.1021/bk-2011-1076.ch006.

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Ludington, Jennifer L. "Virtual Fragment Preparation for Computational Fragment-Based Drug Design." In Methods in Molecular Biology. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2486-8_4.

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Konteatis, Zenon D. "Design Strategies for Computational Fragment-Based Drug Design." In Methods in Molecular Biology. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2486-8_11.

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Lessel, Uta. "Fragment-Based Design of Focused Compound Libraries." In De novo Molecular Design. Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527677016.ch15.

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Conference papers on the topic "Design à base de fragments"

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Rimba, Paul, Liming Zhu, Xiwei Xu, and Daniel Sun. "Building Secure Applications Using Pattern-Based Design Fragments." In 2015 IEEE 34th Symposium on Reliable Distributed Systems Workshop (SRDSW). IEEE, 2015. http://dx.doi.org/10.1109/srdsw.2015.12.

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Weiderhold, Joseph, David E. Lambert, and Michael Hopson. "Experimental Design and Data Collection for Dynamic Fragmentation Experiments." In ASME 2010 Pressure Vessels and Piping Division/K-PVP Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/pvp2010-25163.

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Experiments have been conducted to investigate the fracture and fragmentation characteristics of a liquid phased sintered (LPS) tungsten and high strength steel alloys. Metal cylinders, each of which was 20.32 cm tall and 5.08 cm inner/5.88 cm outer diameter, were explosively driven to failure. Two complimentary types of experiments were conducted in this series to determine input parameters for a related continuum mechanics based modeling effort. Open air experiments utilized ultra-high speed framing photography and a photonic Doppler velocimetry system (PDV). The information from these exper
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Spirochkin, Yury K. "Comparative Hydrodynamic Analysis of the Bimanual Phacoemulsification Technique in Cataract Surgery." In ASME 2008 9th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2008. http://dx.doi.org/10.1115/esda2008-59578.

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The phacoemulsification method used in cataract surgery is considered. In general, it can be realized by two different techniques. The most widespread technique is based on the use of instruments combining both the function of aspiration of crystalline lens fragments and the function of irrigation of substituting fluid in the same coaxial tip. The bimanual phacoemulsification is an alternative technique, which means carrying out of aspiration and irrigation by two divided tips. Advantages of the bimanual technique are revealed by hydrodynamic analysis on base of simplified mathematical modelin
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Zhang, Chongsheng, Ruixing Zong, Shuang Cao, Yi Men, and Bofeng Mo. "AI-Powered Oracle Bone Inscriptions Recognition and Fragments Rejoining." In Twenty-Ninth International Joint Conference on Artificial Intelligence and Seventeenth Pacific Rim International Conference on Artificial Intelligence {IJCAI-PRICAI-20}. International Joint Conferences on Artificial Intelligence Organization, 2020. http://dx.doi.org/10.24963/ijcai.2020/779.

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Oracle Bone Inscriptions (OBI) research is very meaningful for both history and literature. In this paper, we introduce our contributions in AI-Powered Oracle Bone (OB) fragments rejoining and OBI recognition. (1) We build a real-world dataset OB-Rejoin, and propose an effective OB rejoining algorithm which yields a top-10 accuracy of 98.39%. (2) We design a practical annotation software to facilitate OBI annotation, and build OracleBone-8000, a large-scale dataset with character-level annotations. We adopt deep learning based scene text detection algorithms for OBI localization, which yield a
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Winston, Howard, and Sharayu Tulpule. "Fault Mode Analysis Based on Compositional Modeling." In ASME 1997 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/97-gt-034.

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Fault modes are difficult to model because they are often caused by or result in highly-nonlinear or discontinuous changes in an engineered system. These changes will typically invalidate some of the assumptions and simplifications that justify the simulation’s equation model. Thus, a framework for failure simulation should support the dynamic modification of equation models as required by changes in simulated physical conditions. To address this problem, a framework for simulating failure modes in gas turbine engines has been implemented based on prior work on compositional modeling. We belie
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Hedjazi, Lotfi, Christophe L. Martin, Sofiane Guessasma, Guy Della Valle, and Rémy Dendievel. "Application of Discrete Element Simulation to the Crushing of a Food Biopolymer Foam for Mastication Modelling." In ASME 2012 11th Biennial Conference on Engineering Systems Design and Analysis. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/esda2012-82953.

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The fragmentation behaviour of brittle airy cereal foods is studied both numerically and experimentally. The food item is subjected to severe compression until densification stage. Experimental evidence of typical cellular material behaviour is pointed out by elasticity, cell collapse and densification regimes. Using an accurate description of the cellular structure determined by X-ray tomography, a numerical approach based on discrete element method is proposed in order to better explain the resulting fragmentation. The approach allows to reproduce the deformation stages and predicted results
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Lu, Diqun, and Jiamin Zhao. "Design of High-Isolation Fragment-Type 5G Base Station Antennas with MOEA/D-GO." In 2020 International Symposium on Antennas and Propagation (ISAP). IEEE, 2021. http://dx.doi.org/10.23919/isap47053.2021.9391504.

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Suwa, Tohru, Hamid Hadim, and Yong Shi. "Multidisciplinary Design and Optimization for Oscillating Flow Polymerase Chain Reaction Microfluidics Device." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-11820.

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A Polymerase Chain Reaction (PCR) process is almost always required prior to DNA (deoxyribonucleic acid) analysis to create multiple copies of DNA fragments. Using microfluidics technology, the PCR process requires much shorter process time and much less DNA samples than conventional PCR systems. Among existing microfluidics-based techniques, the oscillating flow PCR has advantages including faster analysis time than cavity PCR microfluidics, and smaller contact area between the sample and polymer channel wall compared to flow-through PCR. The smaller contact area reduces DNA adsorption and en
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Cash, Jamie, Gary Rochau, Donald King, and Charles Morrow. "Conceptual Analysis of Criticality Aspects of Fission Electric Cell Reactors." In 10th International Conference on Nuclear Engineering. ASMEDC, 2002. http://dx.doi.org/10.1115/icone10-22545.

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The U.S. Department of Energy’s Nuclear Energy Research Initiative Direct Energy Conversion project has a goal of developing direct energy conversion (DEC) processes suitable for commercial development. DEC is any fission process that returns usable energy with no intermediate thermal process. This project includes the study of the fission electric cell (FEC). In the FEC, fission fragments exit the fuel element cathode and are collected by the cell anode. Previous work [1] has shown the potential of FECs with theoretical efficiencies up to 60%. Inspection of this work indicates the need for ad
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Dogan, Bilal. "High Temperature Damage and Failure Assessment of Plant Components." In ASME 2011 Pressure Vessels and Piping Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/pvp2011-57885.

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A comprehensive approach for the treatment of components operating at high temperature is of immediate industrial interest. Particularly, the components with weldments in currently aging plants are prone to failure. Although these components are designed for base load operation, they are now forced to cyclic operation. This important issue needs to be addressed by a methodology that will be developed and incorporated into design codes such as ASME, as well as in Fitness-for-Service (FFS) assessment procedures (e.g. API 579/ASME FFS1, R5, RCC-MR A16) for in-service plant components. Assessment
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Reports on the topic "Design à base de fragments"

1

Chamberlain, Emma. Defining the tax base: design issues. CAGE, 2020. http://dx.doi.org/10.47445/108.

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R.J. Garrett. Nuclear Safety Design Base for License Application. Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/895368.

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Johnson, Richard William. L-Base Lathe Lifting Arm (preliminary design). Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1356111.

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EZELL, Barry C., and Mark J. Davis. Base Camp Design: Site Selection and Facility Layout. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada399762.

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Bjorkner, Erik, Jerry Brennan, Robert Brooks, et al. Advanced Sea Base Enabler (ASE) Capstone Design Project. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada510979.

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DEPARTMENT OF DEFENSE WASHINGTON DC. Military Standard Generic Transformed Data Base Design Standard. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada280177.

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Leahy, Daniel J. Structure and Machanism-Base Design of ErbB Receptor Inhibitors. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada443243.

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DEPARTMENT OF DEFENSE WASHINGTON DC. Standard Simulator Data Base (SSDB) Interchange Format (SIF) Design Standard. Defense Technical Information Center, 1993. http://dx.doi.org/10.21236/ada281516.

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Hart, Gary C., and Rami Elhassan. Seismic Design Criteria for Base Isolated U.S. Navy Essential Buildings. Defense Technical Information Center, 1989. http://dx.doi.org/10.21236/ada213231.

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Ullman, Jeffrey D. Research into the Design and Implementation of Knowledge-Base System. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada247039.

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