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Dissertations / Theses on the topic 'Design à base de fragments'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Hoffer, Laurent. "Développement et validation du logiciel S4MPLE : application au docking moléculaire et à l'optimisation de fragments assistée par ordinateur dans le cadre du fragment-based drug design." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00874644.

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Cette thèse a pour but de développer le pendant in silico des étapes clés du Fragment-Based Drug Design (FBDD), et ce dans le cadre plus général du développement de l'outil S4MPLE. Le FBDD génère des ligands drug-like à partir de petites molécules (fragments). Après une étape de validation de S4MPLE et de sa fonction d'énergie, un recentrage autour du FBDD est réalisé, à travers le docking puis l'optimisation virtuelle de fragments par growing ou linking (G/L). Cette stratégie reposesur 1) la création d'une chimiothèque focalisée en connectant un ou deux fragment(s) avec des linkers pré-généré

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2

Barelier, Sarah. "Probing protein-small molecule interactions by Nuclear Magnetic Resonance : towards a better understanding of the Fragment-Based Drug Design methodology." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10222.

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La méthode de conception de médicaments à partir de molécules « fragments » (connue sous le nom de « Fragment-Based Drug Design ») a été proposée au milieu des années 90, et a depuis été reconnue comme une alternative tangible aux techniques plus classiques de recherche de médicaments telles que le criblage à haut débit par exemple. La méthode des fragments consiste à cribler un petit nombre (< 10000) de composés organiques de faible poids moléculaire (< 300 Da) afin de détecter ceux qui se lient à la cible (protéine ou acides nucléiques). Du fait de leur faible complexité, les fragments

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3

Rahimova, Rahila. "Structure-based drug design of allosteric ecto-5'-nucleotidase inhibitors : application to cancer treatment." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT039.

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Le cancer représente l'un des problèmes majeurs en santé publique. Jusqu'à présent, en parallèle de l'intervention chirurgical, plusieurs traitements ont été mis au point et largement utilisés en thérapie clinique telles que les chimiothérapies. Cependant, leur efficacité est parfois limitée et couplée à des effets secondaires très néfastes, laissant les patients dans une impasse thérapeutique. Par conséquent, de nouvelles approches thérapeutiques doivent être développées sur de nouvelles cibles avérées en oncologie afin d'apporter des soins personnalisés aux patients. La première partie de mo

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4

Lepron, Marco. "Conception de ligands allostériques du sous-type α5 des récepteurs nicotiniques à l'acétylcholine". Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS584.

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Les récepteurs nicotiniques à l’acétylcholine (nAChRs) sont des protéines transmembranaires appartenant à la superfamille des canaux ioniques pentamériques activés par des ligands (pLGICs). Impliqués dans la transmission et la modulation de l’influx nerveux, ils sont à ce jour des cibles thérapeutiques privilégiées pour le traitement de neuropathologies telles que la maladie d’Alzheimer, la schizophrénie ou encore l’addiction au tabac. Les nAChRs neuronaux les plus répandus sont les sous-types α7 (homomérique) et α4β2 (hétéromérique). La sous-population mineure des récepteurs α5(α4β2)2 contena

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5

Sartori, Geraldo Rodrigues. "Planejamento de inibidores baseado em fragmentos moleculares para a enzima gliceraldeído-3-fosfato desidrogenase de Trypanosoma cruzi." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-24072012-142746/.

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A Doença de Chagas, endêmica na América Latina, é causada pelo parasito tripanossomatídeo Trypanosoma cruzi e atualmente já se espalha para o restante do mundo devido à migração humana. Os dois medicamentos disponíveis para o tratamento dessa doença, o Nifurtimox, (banido do Brasil), e o Benzonidazol, são eficazes somente na etapa aguda da doença e possuem efeitos colaterais severos. Recentemente, três novas substâncias para o tratamento chegaram à fase clínica de testes contra essa doença, mas ainda é necessária a pesquisa de novas moléculas contra esse parasito. A enzima Gliceraldeído-3-fosf

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6

Villemagne, Baptiste. "Conception, synthèse et dévelopement d'inhibiteurs du répresseur transcriptionnel mycobactérien ETHR selon une approche par fragments. Une nouvelle approche dans la lutte contre la tuberculose." Thesis, Lille 2, 2012. http://www.theses.fr/2012LIL2S052/document.

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Avec plus d’un million et demi de morts chaque année, la tuberculose reste aujourd’hui la seconde cause de mortalité liée à un agent infectieux. De plus l’organisation mondiale de la santé (OMS) a estimé en 2011 qu’un tiers de la population mondiale était porteuse du bacille Mycobacterium tuberculosis responsable de la maladie. Depuis la fin des années 1980, une recrudescence du nombre de cas de tuberculose est observée à l’échelle mondiale. Cette recrudescence est due à la fois à l’apparition de souches résistantes, mais également à l’épidémie de VIH qui est un facteur de prédisposition au dé

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7

Hayes, Edward. "Fragment based design of cholera toxin inhibitors." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534749.

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8

Craan, Tobias Friedrich [Verfasser], and Gerhard [Akademischer Betreuer] Klebe. "Fragment based Drug Discovery : Design and Validation of a Fragment Library ; Computer-based Fragment Screening and Fragment-to-Lead Expansion / Tobias Friedrich Craan. Betreuer: Gerhard Klebe." Marburg : Philipps-Universität Marburg, 2011. http://d-nb.info/1013288807/34.

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9

Woodlock, David A. "Application of molecular mechanics polarization to fragment based drug design." Thesis, University of Essex, 2015. http://repository.essex.ac.uk/16774/.

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Polarization is a term that is often excluded from almost all virtual screening. Polarizability helps explain interactions between nonpolar atoms and electrically charged species. When studying fragments in FBDD these minor interactions could have large effect in changing how well a ligand will bind to its target. After including the polarizability terms in docking a validation set of ligands (Favia et al., 2011) with GLIDE, it improved the results the amount good docked poses (< 2 Å RMSD) by up to 12%. However some ligands were bound in incorrect poses. Further investigation was carried out w

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10

Venot, Pierre-Etienne. "Synthèse stéréosélective d'Hybrides de lobéline et de ligands naturels des récepteurs nicotiniques centraux à l’acétylcholine." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA114813/document.

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Au cours de ce travail, nous avons développé des voies de synthèses convergentes et énantiosélectives en vue de préparer des analogues pyrrolidiniques des alcaloïdes de Lobelia comme nouveaux ligands des récepteurs nicotiniques à l’acétylcholine. Deux familles de ligands ont été réalisées par des méthodes d’élongation mono- ou bi-directionnelle basées respectivement sur des stratégies de désymétrisation précoce ou tardive au départ du succinaldéhyde.La première partie de ce manuscrit aborde la conception d’hybrides de lobéline, nicotine et d’agonistes naturels. Ces structures originales ont ét

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11

Marcén, Terraza Ana Cristina. "Design of a Machine Learning-based Approach for Fragment Retrieval on Models." Doctoral thesis, Universitat Politècnica de València, 2021. http://hdl.handle.net/10251/158617.

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[ES] El aprendizaje automático (ML por sus siglas en inglés) es conocido como la rama de la inteligencia artificial que reúne algoritmos estadísticos, probabilísticos y de optimización, que aprenden empíricamente. ML puede aprovechar el conocimiento y la experiencia que se han generado durante años en las empresas para realizar automáticamente diferentes procesos. Por lo tanto, ML se ha aplicado a diversas áreas de investigación, que estudian desde la medicina hasta la ingeniería del software. De hecho, en el campo de la ingeniería del software, el mantenimiento y la evolución de un sistema

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12

McConnell, Brendan Neil. "Fragment-based approaches to targeting EthR from mycobacterium tuberculosis." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/290255.

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Tuberculosis affects millions of people worldwide every year. The current treatment for TB is divided into a regimen of both first- and second-line drugs, where first-line treatments are more tolerated and require shorter treatment lengths. With rising levels of resistance, alternative treatment regimes are urgently needed to fight this disease. Ethionamide, a second-line drug is administered as a prodrug which is activated in vivo by the enzyme EthA, which is in turn regulated by EthR. The disruption of the action of EthR could lead to novel therapeutics which could enhance the efficacy of et

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13

Slattery, John Martin. "Structural design with reactive main group fragments." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413610.

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14

Schulz, Robert [Verfasser]. "Reaction-Driven Fragment-Based Design of Viral Protease Inhibitors / Robert Schulz." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1151120855/34.

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15

Chevillard, Florent [Verfasser], and Peter [Akademischer Betreuer] Kolb. "Improved approaches to ligand growing through fragment docking and fragment-based library design / Florent Chevillard ; Betreuer: Peter Kolb." Marburg : Philipps-Universität Marburg, 2016. http://d-nb.info/1119318106/34.

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16

Cunha, Christian da. "Polymères à base de fragments de lignine : synthèse et caractérisations structurales." Bordeaux 1, 1991. http://www.theses.fr/1991BOR10542.

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Divers procedes, a savoir la polymerisation radicalaire en chaine et la polycondensation, sont susceptibles de permettre l'incorporation des fragments de lignine issus de l'hydrolyse eclair de materiaux ligno-cellulosiques, dans des chaines macromoleculaires. L'etude detaillee de la polymerisation du methacrylate de methyle, par voie radicalaire, en presence de lignine, acetylee ou non, revele l'action jouee par certaines fonctions inhibitrices et d'agent de transfert de la lignine. L'influence de ces reactions sur la structure des copolymeres obtenus est discutee. L'ancrage de groupements pol

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17

Guca, Ewelina. "Caractérisation structurale de la CTP : phosphocholine cytidylyltransférase de Plasmodium falciparum et identification de composés inhibiteurs basée sur la structure visant à cibler la voie de biosynthèse des phospholipides." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT077.

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À l’heure actuelle, le paludisme reste un problème de santé majeur et demeure une des maladies parasitaires les plus menaçantes. Parmi les cinq espèces de malaria infectant l’homme, Plasmodium falciparum est la forme la plus mortelle. Lors de la phase érythrocytaire de son cycle de vie, causant tous les symptômes du paludisme, P.falciparum utilise les phospholipides pour créer les membranes nécessaires au développement de cellules filles. Chez P. falciparum, la phosphatidylcholine est principalement obtenue grâce à la voie de synthèse de novo, dite voie de Kennedy. Dans cette voie de biosynthè

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18

Schulz, Michèle Nadine. "Fragment based ligand discovery : library design and screening by thermal shift analysis." Thesis, University of York, 2012. http://etheses.whiterose.ac.uk/3133/.

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The central idea in Fragment Based Ligand Discovery (FBLD) is to identify small, low molecular weight compounds (MW < 250) that bind to a particular protein active site. Hits can be used to efficiently design larger compounds with the desired affinity and selectivity. Three approaches to FBLD are described in this thesis. The first topic is the development and assessment of different chemoinformatics procedures to select those fragments that maximally represent the chemical features of a larger compound library. Such a fragment library could be of great value in the so-called “SAR by Catalogue

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19

Regep, Cristian. "Using structural fragments to design antibody binding sites." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:ea451137-45ac-446f-bf29-e15408f05869.

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Antibodies are an essential part of the immune system. They are able to attain high specificity and affinity to almost any antigen, and through their modularity make a robust framework for protein engineering. As a result, development of therapeutic antibodies has grown rapidly and they now account for the majority of revenue in the sales of new bio-therapeutics. The established design methods are heavily based on experimental simulation of the antibody maturation process outside of the human organism, and make little use of rational computational design methods. In this thesis we analysed the

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20

deFilippis, Audrey. "Urban Collision - Design Opportunities in Tensions and Fragments." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1277144387.

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21

Thompson, Matthew. "Fragments from a future archive." Thesis, Kingston University, 2011. http://eprints.kingston.ac.uk/23891/.

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This PhD introduces new ways to configure the archive as a source of knowledge. This is because it is based in an art practice whose field of interest is institutional critique which determines that knowledge is both contingent and uncertain as different social and political factors come into play. The project pursues a line of inquiry which absorbs the artist, where the artist is seen to affect and be affected by the materials of an existing archive. The inquiry produces new connections and layers of meaning in relation to the archive whilst exposing and recording the precise methods and moti

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22

Radoux, Christopher John. "The automatic detection of small molecule binding hotspots on proteins : applying hotspots to structure-based drug design." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/275133.

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Locating a ligand-binding site is an important first step in structure-guided drug discovery, but current methods typically assess the pocket as a whole, doing little to suggest which regions and interactions are the most important for binding. This thesis introduces Fragment Hotspot Maps, a grid-based method that samples atomic propensities derived from interactions in the Cambridge Structural Database (CSD) with simple molecular probes. These maps specifically highlight fragment-binding sites and their corresponding pharmacophores, offering more precision over other binding site prediction m

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23

Renard, Martial. "Construction de biocapteurs à partir de fragments d'anticorps." Paris 6, 2003. http://www.theses.fr/2003PA066282.

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24

Wheldon, Mary Christine. "Design and synthesis of 3-dimensional fragments to explore pharmaceutical space." Thesis, University of York, 2016. http://etheses.whiterose.ac.uk/16659/.

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This thesis describes an approach to the design, analysis and synthesis of saturated nitrogen heterocyclic fragments to explore pharmaceutical space. Firstly, the development of a computational protocol for the shape analysis of fragments is described (Chapter 2). Principal moments of inertia (PMI) plots were used to generate a set of selection criteria to select compounds found in the 3-dimensional area of the PMI plot. The computational method was applied to different scaffolds, piperidine, pyrrolidine and azepane, to generate a 3-dimensional fragment library. The computational analysis of a

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25

Habib, Eric. "Designing an inhibitor for AAC(6')- Ii by fragment-based drug design using SAR by NMR." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119433.

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Aminoglycosides are valuable broad-spectrum antibiotics effective in both Gram-positive and Gram-negative bacteria. Antibiotic resistance has however been a scourge since the advent of modern antibiotics. One of the main mechanisms of resistance to aminoglycosides is antibiotic modification by the clinically widespread enzyme aminoglycoside N-6'-acetyltransferase (AAC(6')). Inhibiting resistance-causing enzymes is an important strategy among the multiple approaches to counter antibiotic resistance. The Auclair lab has previously developed a series of aminoglycoside-coenzyme A bisubstrates t

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26

Li, Huameng. "Multiple Ligand Simultaneous Docking (MLSD) and Its Applications to Fragment Based Drug Design and Drug Repositioning." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1324606149.

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27

Spink, Ian. "Ligand discovery for protein-protein interaction targets using 19F NMR-based screening of novel peptide and fragment libraries." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31536.

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The main aim of this thesis was to discover and design new ligands for difficult, under-explored and clinically relevant protein targets. A number of protein-protein interaction complexes (PPIs) are introduced as the target focus for the methods employed and developed herein. This thesis is separated into two sections to independently address both peptides and small molecules as screening agents. The project examines both approaches through comprehensive library design strategies and screening by NMR spectroscopic methods. ATAD2 is the first PPI investigated and was expressed and purified in g

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28

Flaherty, Kristen R. "Fragments of Narrative: Hidden Voices of the Archival Process." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1336742036.

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29

Luise, Nicola. "To design and develop semi-saturated and unsaturated bicyclic heterocycles for Fragment-Based Drug Discovery (FBDD) Campaigns." Thesis, University of Dundee, 2019. https://discovery.dundee.ac.uk/en/studentTheses/d7ded7f8-d7ad-4271-a855-42393b41766f.

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The concept of Fragment-Based Drug-Discovery (FBDD) seeks to overcome current issues associated with High-Throughput Screening (HTS) for the identification of novel hits, which are ultimately elaborated into leads and drug candidates. This thesis focuses on the preparation of either novel or commercially limited fragments by engaging diverse synthetic strategies. Moreover, a fragment optimisation process is discussed. Chapter 2 details the generation of fully unsaturated and semi-saturated bicyclic heterocycles by adopting the concept of reagent- and scaffold-based Diversity-Oriented Synthesis

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30

Davis, Caroline M. "Investigation and Characterisation of Protein-Ligand Interactions: SRA-Ribonucleic Acid Recognition and Anti-Microbial Drug Discovery." University of Akron / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1437779075.

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31

Shah, Drishti Rajesh. "LOST FRAGMENTS A Therapy Center to cope with grief in Richmond, Virginia." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/90773.

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An exploration began to understand the relationship between architecture and human emotion. Inspired by a personal story of loss, this thesis began to disseminate the five stages of the Elizabeth Kübler Ross model of grief. Each of the stages was studied in depth to find architectural elements that relate to every stage. Furthermore, the elements helped establish a mood and quality of the spaces that were directly associated with program, light, and material. As the project began to evolve, a series of questions of architectural sequence, material practices, and placemaking followed and with

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32

Siebert, Erin. "The memory laboratory : reclaiming and remebering the archeological fragments of Cape Town's original shoreline." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/24378.

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This thesis project began with an interest in public space and particularly the role of collective urban memory in reading and understanding public space in the city, as well as being a means of imbuing public space with meaning. This is closely linked to ideas of shared experience, identity and legacy. These ideas are widely discussed and debated in the making of architecture in our post colonial, post apartheid context. My interest is in the development of inclusive collective memories and how these histories become part of the everyday life of the city. Architecture and urban design play a

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33

Tanina, ABDALKARIM. "Structural analysis of transcription factors involved in Mycobacterium tuberculosis mycolic acid biosynthesis." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/309485.

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Tuberculosis (TB) remains the leading cause of death due to a single infectious agent with more than 1.5 million people killed each year. In 2018, the World Health Organization (WHO) estimated that one third of the world’s population was infected with Mycobacterium tuberculosis (Mtb), the pathogen responsible for the disease.In 2000, EthR, a mycobacterial transcriptional repressor, was identified as a key modulator of ethionamide (ETH) bioactivation. ETH is one of the main second-line drugs used to treat drug-resistant strains and it is a prodrug that is activated in Mtb by the mono-oxygenase

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34

Sjölin, Olof. "Synthesis of Substituted Pyrrolidines." Thesis, KTH, Skolan för kemivetenskap (CHE), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207056.

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The task of medicinal chemists in a drug discoveryproject is to synthesize/design analogues to the screening hits, simultaneouslyincreasing target potency and optimizing the pharmacological properties. This requires a wide selection of moleculesto be synthesized, where both synthetic feasibility and price of startingmaterials are of great importance. In this work, a synthetic pathway from cheapand readily available starting materials to highly modifiable 2,4-disubstitutedpyrrolidines is demonstrated. Previously reported procedures to similarpyrrolidines use expensive catalysts, requires harsh

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Ali, Rashid Majid Yousif. "Fragment-screening by X-ray crystallography of human vaccinia related kinase 1." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166811.

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Fragment-screening by X-ray crystallography (XFS) is an expensive and low throughput fragment drug discovery screening method, and it requires a lot of optimization for each protein target. The advantages with this screening method are that it is very sensitive, it directly gives the three-dimensional structure of the protein-fragment complexes, and false positives are rarely obtained. The aim of this project was to help Sprint Bioscience assess if the advantages with XFS outweigh the disadvantages, and if this method should be used as a complement to their differential scanning fluorimetry (D

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Sun, Mengmeng. "COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR VISUALIZING SNOMED CT FRAGMENTS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1436373297.

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Khattri, Ram Bahadur. "Identifying selective ligands for glutaredoxin proteins with fragment based drug design approach and optimization of the bacterial selective hits." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460988438.

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Denis, Camille. "Conception, synthèse et évaluation biologique d'inhibiteurs des protéines de la famille Bcl-2 à visée anticancéreuse : applications aux cancers de l'ovaire chimiorésistants." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC424.

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Les interactions protéine-protéine (IPPs) contrôlent de nombreux processus physiologiques importantsdans les cellules humaines. Une caractéristique des cancers est l'échappement des cellules àl'apoptose, qui est souvent associé à la surexpression de protéines anti-apoptotiques, membres de lafamille de protéines Bcl-2. Cette famille comprend des membres anti-apoptotiques (Bcl-2, Bcl-xL,Mcl-1) et pro-apoptotiques. Dans de nombreux cancers dont les cancers de l’ovaire chimiorésistants,l'équilibre entre les membres pro- et anti-apoptotiques de la famille de protéines Bcl-2 est altéré etconduit à l

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Wu, Tai-Chieh 1976. "Design of base isolation system for buildings." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/84293.

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Hartland, A. J. "Dispersed base combat aircraft." Thesis, Cranfield University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237543.

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41

Bayar, Gokhan. "Configurable Robot Base Design For Mixed Terrain Applications." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/2/12606530/index.pdf.

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Mobile robotics has become a rapidly developing field of interdisciplinary research within robotics. This promising field has attracted the attention of academicy, industry, several government agencies. Currently from security to personal service mobile robots are being used in a variety of tasks. The use of such robots is expected to only increase in the near future. In this study, it is aimed to design and manufacture a versatile robot base. This base is aimed to be the main driving unit for various applications performed both indoors and outdoors ranging from personal service and assistanc

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Hatchell, Brian. "Data base design for integrated computer-aided engineering." Thesis, Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/16744.

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Bjorkner, Erik, Jerry Brennan, Robert Brooks, et al. "Advanced Sea Base Enabler (ASE) Capstone Design Project." Thesis, Monterey, California. Naval Postgraduate School, 2009. http://hdl.handle.net/10945/6943.

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As part of a Naval Postgraduate School's capstone project in Systems Engineering, a project team from cohort 311-081 performed a Systems Engineering analysis of an Advanced Sea Base Enabler (ASE). For a sea base to be truly beneficial a capability must exist that supports efficiently transporting needed materiel from the sea base to the desired debarkation point. The capability must support peace-time, non-combat operations' and war-time, combat operations' logistics and support needs. The solution must be cost effective and capable of operating under all environmental conditions, includi

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Wang, Andrew Yu 1976. "Base station design for a wireless microsensor system." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/86627.

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Campbell, Ira lee. "Sustainable energy in military base design & layout." Thesis, Georgia Institute of Technology, 2016. http://hdl.handle.net/1853/55072.

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The purpose of this study is to exlpore the possibilities of power generation using human and mechanical means. This paper will introduce alternative means, methods, and procedures for the implementation of cutting edge technologies to address the energy needs for today and the future. Further, this project will serve as an aid in the development of a base camp facility layout optimization system by understanding the proximity relationships between base camp components, developing a facility layout domain, and comparing generated layouts to existing models and camps.

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46

Widajat, Djoko. "Predicting the performance of basaltic aggregate for use in unbound road base and sub base layers." Thesis, University of Ulster, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365923.

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Amadi, Cecilia Nwadiuto. "Biochemical and drug targeting studies of Mycobacterium tuberculosis cholesterol oxidase P450 enzymes." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/biochemical-and-drug-targeting-studies-of-mycobacterium-tuberculosis-cholesterol-oxidase-p450-enzymes(16cbca7a-b8b2-4ec4-bbd7-977785ed65b9).html.

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Mycobacterium tuberculosis (Mtb), a deadly pathogen, has scourged mankind for many centuries and has remained a major threat to global world health. Tuberculosis, the disease caused by this bacterium, is a major cause of death in developing nations and there is potential for its re-emergence in developed countries. An alarming rise in cases of multidrug-resistant and extremely-drug resistant tuberculosis (MDR-TB and XDR-TB) that do not respond to the customary first-line antibiotics necessitates the urgent need for development of new anti-TB drugs. Mtb becomes engulfed in human macrophages pos

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Ben, Hafaiedh Imane. "Systèmes à base de composants : du design à l'implémentation." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00573291.

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Dans cette thèse, nous nous sommes intéressés aux design, vérification et implémentation des systèmes à base de composants. Nous proposons d'abord une méthodologie de design et de vérification compositionelle et incrémentale à base de contrats pour les systèmes de composants. Nous proposons ensuite une implémentation distribuée qui permet de préserver certaines properiétés globales de ces systèmes. La méthodologie de design proposée utilise les contrats comme un moyen de contraindre, raffiner et d'implémenter les systèmes. Elle est basée sur un formalisme de contracts générique, que nous insta

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Andresen, Even Sunde. "Design of an Offshore Standby Base for Remote Regions." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for marin teknikk, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-22390.

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In this Master?s thesis an optimization model for finding the optimal design of a standby base operating in remote regions is presented. The research and development within optimization of standby vessel design is limited. The objective of this thesis has been to utilize the state of the art within the areas of maritime fleet optimization, ship design optimization and the analytical hierarchy process in the development of a working model. Application of emergency preparedness assessment processes in the North Sea as quantifiable mathematical restrictions is also addressed.By developing a linea

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Zhang, Fengdong. "Distributed database and knowledge base modeling for concurrent design." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ65016.pdf.

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