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Journal articles on the topic 'Design cellule'

Author: Grafiati

Published: 20 July 2024

Last updated: 31 July 2025

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1

Vályi-Nagy, Marianna, Attila Rácz, Katalin Irmes, et al. "Evaluation of the Development Process of Winter Wheat (Triticum aestivum L.) and Winter Pea (Pisum sativum L.) in Intercropping by Yield Components." Agronomy 13, no. 5 (2023): 1323. http://dx.doi.org/10.3390/agronomy13051323.

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The future of wheat production depends on our ability to adapt to changing growing conditions. It is expected that intercropping will be more emphasized where natural source of nitrogen may increase the resilience of cereals. Our investigation was made in two growing seasons (2020–2021, 2021–2022) with three winter wheat varieties (GK Szilárd, Cellule, GK Csillag) and a winter pea variety (Aviron) in Szeged-Öthalom. Each plot was 10 square meters in four repeats in randomized block design. We used a seed mixture of both species with three sowing densities. In this study, we represent a develop

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2

Giugliano, Giovanna, Mario Buono, and Sonia Capece. "Design per configurare nuovi luoghi e spazi di apprendimento adattivi." i+Diseño. Revista Científico-Académica Internacional de Innovación, Investigación y Desarrollo en Diseño 16 (December 16, 2021): 107–24. http://dx.doi.org/10.24310/idiseno.2021.v16i.12804.

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Diseñar formas y espacios de aprendizaje es un proceso que requiere creatividad pedagógica, arquitectónica, social, cultural y política.La literatura científica nacional e internacional (OCDE, 2017) sobre innovación educativa destaca la estrecha relación que conecta la didáctica con el entorno de aprendizaje. Por ello, los procesos de renovación educativa no pueden prescindir de una nueva visión de los espacios escolares y de los entornos educativos.Surgen nuevas pautas de planificación escolar, se enfatiza el aprendizaje como un proceso activo y constructivo en el que cada niño tiene un p

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3

Masrina, Angel Bintang, Muhammad Amin, and Pristiyanilicia Putri. "Implementasi E-CRM Untuk Meningkatkan Penjualan Produk Di Toko Matrix Celluler Berbasis Web." JUTSI (Jurnal Teknologi dan Sistem Informasi) 2, no. 2 (2022): 77–84. http://dx.doi.org/10.33330/jutsi.v2i2.1683.

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Abstract : Matrix Celluler who is on the road Prof. H.M. Yamin No.16, Kisaran Naga, Kec. Kisaran Eastern, Asahan Regency, North Sumatera namely store that process transactions in cash and credit with sales products namely Handphone Samsung, Vivo, Oppo, dan Nokia. Besides Handphone, Matrix Celluler also provide Accessories in the form of Charger, Antigores, Handsfree, and Softcase. This research was conducted with the aim of designing a new system, namely Customer Relationship Management that is attractive and effective for sales and customer service according to the needs of the store and cust

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4

Akintomide, A. A., I. B. Osho, and G. E. Onibi. "Growth performance and haematology of broiler chickens fed enzyme supplemented neem leaf meal -based diets." Nigerian Journal of Animal Production 48, no. 5 (2021): 152–64. http://dx.doi.org/10.51791/njap.v48i5.3196.

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The quest for sustainable poultry production using alternative feed ingredients is imperative. This study was conducted to assess the growth performance and blood profile of broiler chickens fed neem leaf meal (NLM) based diets with or without enzyme supplementation. Two hundred and eighty-eight, one-week old chicks (with an average weight of 98.44g) arranged in a completely randomized design with twelve birds/ replicate and three replicates/ treatment were fed NLM at 0, 1.5, 3 and 5% with or without Polyzme® to form eight experimental treatments. Data on initial body weights, weekly body weig

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5

Dhiman, Rajni, and Puneet Utreja. "DESIGN AND CHARACTERIZATION OF AMLODIPINE BESYLATE TRANSDERMAL PATCHES USING HYDROXY PROPYL METHYL CELLULOSE AND ETHYL CELLULOSE COMBINATION." INDIAN RESEARCH JOURNAL OF PHARMACY AND SCIENCE 7, no. 4 (2020): 2415–31. http://dx.doi.org/10.21276/irjps.2020.7.4.3.

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6

Bahrepour, Davoud. "A Novel Full Comparator Design Based on Quantum-Dot Cellular Automata." International Journal of Information and Electronics Engineering 5, no. 6 (2015): 406–10. http://dx.doi.org/10.7763/ijiee.2015.v5.568.

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7

Nozari, Mehrnaz, and Hamed Nahr. "ENGINEERING CELLULAR HARMONY: A COMPREHENSIVE LITERATURE REVIEW ON CELL PRODUCTION SYSTEM DESIGN." American Journal of Management and Economics Innovations 6, no. 1 (2024): 6–11. http://dx.doi.org/10.37547/tajmei/volume06issue01-02.

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This literature review delves into the intricate domain ofcell production system design, offering a comprehensive exploration of the methodologies, technologies, and advancements that contribute to engineering cellular harmony. The study synthesizes key findings from a broad spectrum of research, providing insights into the diverse strategies employed in designing cell production systems. By analyzing current trends, challenges, and future directions, this review aims to guide researchers, engineers, and practitioners in advancing the field of cell production system design.

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8

Moh., Awaludin Adam, and Maftuch. "CONDITION TOTAL LEUKOCYTES AND PLASMA PROTEIN KOI FISH (Cyprinus carpio Koi) POST SOAKING EXTRACT GRACILARIA VERRUCOSA INFECTED BACTERIA Aeromonas salmonicida." Samakia: Jurnal Ilmu Perikanan 8, no. 1 (2017): 11–18. https://doi.org/10.5281/zenodo.556715.

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The study was conducted to determine total leucocyte and plasma protein of infected Koi (<em>Cyprinus carpio</em>) after immersion in the extract of Gracillaria verrucosa. The experimental design of this research was Completely Randomized Design. Different doses of extract were used five treatments and three replicates. Data was analyzed by using ANOVA (one-way) there were significant different of total leucocyte. Total protein plasma at treatments of fish infected, showed protein of ben thinner. Doses immersion treatments at 19 ppm get significant effects of humoral and celluler system the in

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9

Shahidinejad, Ali, Ali Farrokhtala, Saman Asadi, Maryam Mofarrahi, and Toni Anwar. "A Novel Quantum-Dot Cellular Automata XOR Design." Advanced Materials Research 622-623 (December 2012): 545–50. http://dx.doi.org/10.4028/www.scientific.net/amr.622-623.545.

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Quantum-dot cellular automata (QCA) is an emerging nanotechnology that promises faster speed, smaller size, and lower power consumption compared to the transistor-based technology. Moreover, XOR is a useful component for the design of many logical and functional circuits. This paper proposes a novel and efficient QCA XOR design. The proposed XOR design has been compared to a few recent designs in terms of area, speed and complexity. Comparison of results illustrates significant improvements in our design as compared to traditional approaches. Also simulation proves that the proposed XOR design

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10

Aiba, Yuichiro, Gerardo Urbina, Masanari Shibata, and Osami Shoji. "Investigation of the Characteristics of NLS-PNA: Influence of NLS Location on Invasion Efficiency." Applied Sciences 10, no. 23 (2020): 8663. http://dx.doi.org/10.3390/app10238663.

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Peptide nucleic acid can recognise sequences in double-stranded DNA (dsDNA) through the formation of a double-duplex invasion complex. This double-duplex invasion is a promising method for the recognition of dsDNA in cellula because peptide nucleic acid (PNA) invasion does not require the prior denaturation of dsDNA. To increase its applicability, we developed PNAs modified with a nuclear localisation signal (NLS) peptide. In this study, the characteristics of NLS-modified PNAs were investigated for the future design of novel peptide-modified PNAs.

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11

De Roos, Albert D. G. "A Proposed Framework for Cellular Evolution." Communications of the Blyth Institute 1, no. 1 (2018): 5–12. http://dx.doi.org/10.33014/issn.2640-5652.1.1.deroos.1.

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   This article shows how a good understanding of the design principles that underlie life is crucial in understanding its evolution. It gives concrete examples on how designs can be applied to evolution in the same way an engineer uses designs in creating building or bridges, or a software engineer that designs programs that can evolve. If we apply the notion of a design for evolution and realize that it is in its basis an evolving system of molecular machines, we can start to reverse engineer evolution and understand life. This article shows scenario’s for the origin of lif

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12

Mottin, Stéphane. "Cytométrie en mode femtoseconde." Morphologie 85 (March 29, 2001): 27–28. https://doi.org/10.5281/zenodo.439018.

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Deux grandes voies de cytométrie sont habituellement distinguées: - cytométrie en flux où les cellules sont analysées à grande vitesse ; - la cytométrie en image, en particulier sur microscope confocal avec analyse d image morphologique intra-cellulaire avec balayage monopoint ou multipoint. Un des points clé des dispositifs optiques associés reste la source lumineuse. Celle-ci est généralement un laser sauf en microscopie confocale bien que dans ce domaine, les nouvelles microscopies fs se développent très rapidement. Les technologies des systèmes fs seront abordées de manière didactique pour

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13

Morant, Laura, Maria-Luise Petrovic-Erfurth, and Albena Jordanova. "An Adapted GeneSwitch Toolkit for Comparable Cellular and Animal Models: A Proof of Concept in Modeling Charcot-Marie-Tooth Neuropathy." International Journal of Molecular Sciences 24, no. 22 (2023): 16138. http://dx.doi.org/10.3390/ijms242216138.

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Investigating the impact of disease-causing mutations, their affected pathways, and/or potential therapeutic strategies using disease modeling often requires the generation of different in vivo and in cellulo models. To date, several approaches have been established to induce transgene expression in a controlled manner in different model systems. Several rounds of subcloning are, however, required, depending on the model organism used, thus bringing labor-intensive experiments into the technical approach and analysis comparison. The GeneSwitch™ technology is an adapted version of the classical

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14

Arsent’ev, M. Yu, S. V. Balabanov, M. M. Sychev, and D. S. Dolgin. "Crystalline Design of Cellular Materials." Glass Physics and Chemistry 46, no. 6 (2020): 657–60. http://dx.doi.org/10.1134/s1087659620060024.

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15

RAJAMANI*, D., N. SINGH, and Y. P. ANEJA. "Design of cellular manufacturing systems." International Journal of Production Research 34, no. 7 (1996): 1917–28. http://dx.doi.org/10.1080/00207549608905004.

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16

Irani, S. A., P. H. Cohen, and T. M. Cavalier. "Design of Cellular Manufacturing Systems." Journal of Engineering for Industry 114, no. 3 (1992): 352–61. http://dx.doi.org/10.1115/1.2899803.

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This paper describes a method for layout design of a Cellular Manufacturing System (CMS) that would allow simultaneously, the grouping of machines unique to a part family into cells and those shared by several cells to be located together in functional sections. Using an illustrative example, this integration of the flexibility of a functional layout, the reduced handling gained from cell formation and allowance of limited intercell flows among adjacent cells is described. Thereby, the traditional strategy of simultaneous formation of part families and distribution of machines into independent

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17

Wells, A. J. "Cellular Facility Design Made Easy." IFAC Proceedings Volumes 23, no. 3 (1990): 341–45. http://dx.doi.org/10.1016/s1474-6670(17)52580-x.

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18

Krakauer, David C., Lydia Müller, Sonja J. Prohaska, and Peter F. Stadler. "Design specifications for cellular regulation." Theory in Biosciences 135, no. 4 (2016): 231–40. http://dx.doi.org/10.1007/s12064-016-0239-5.

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19

Kita, E., and T. Toyoda. "Structural design using cellular automata." Structural and Multidisciplinary Optimization 19, no. 1 (2000): 64–73. http://dx.doi.org/10.1007/s001580050086.

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20

BARBÉ, ANDRÉ. "NECESSITY FROM CHANCE: SELF-ORGANIZED REPLICATION OF SYMMETRIC PATTERNS THROUGH SYMMETRIC RANDOM INTERACTIONS." International Journal of Bifurcation and Chaos 19, no. 04 (2009): 1185–225. http://dx.doi.org/10.1142/s0218127409023585.

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We present an algorithm, completely random in nature, that, without invoking a fitness function or purposeful design, produces symmetric replicas in a population of so-called cellicules. Cellicules consist of "cells" arranged in a structure with geometric symmetry S. Each cell has one of two possible states, thus defining a state-configuration pattern on a cellicule. The algorithm acts recurrently on a population of cellicules, possibly randomly initialized, through a random "copying interaction" between two randomly selected cellicules that first undergo a random reorientation in accordance w

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21

Kim, Ho-Soo, and Min-Ho Lee. "Optimal Shape Design of Space Truss Structure using Topology Optimization and Cellular Automata Model." Journal of the Computational Structural Engineering Institute of Korea 25, no. 1 (2012): 73–80. http://dx.doi.org/10.7734/coseik.2012.25.1.073.

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22

Tayo, G. O., O. O. Olufayo, M. D. Olumide, and A. O. Akintunde. "Growth and haematological parameters of Isa-brown pullets fed Phyllanthus niruri leaf meal as additive at the chick phase." Nigerian Journal of Animal Production 49, no. 2 (2022): 130–39. http://dx.doi.org/10.51791/njap.v49i2.3470.

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Phyllanthus niruri Linn. is an erect annual herb known for its medicinal values; thus, this study was conducted to determine the effect of graded levels of Phyllanthus niruri leaf meal (PNLM) as a substitute antibiotic feed additive on the performance and haematological parameters of pullets at the chicks phase. Four hundred and eighty, 4 weeks old pullets weighing between 204.38 - 215.63g were fed diets containing Phyllanthus niruri leaf meal for 35 days in a completely randomized design experimental layout. Treatments were: T1(0% PNLM), T2 (antibiotics), T3 (0.2%PNLM), T4 (0.3%PNLM), T5 (0.4

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23

Bhate, Dhruv. "Four Questions in Cellular Material Design." Materials 12, no. 7 (2019): 1060. http://dx.doi.org/10.3390/ma12071060.

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The design of cellular materials has recently undergone a paradigm shift, enabled by developments in Additive Manufacturing and design software. No longer do cellular materials have to be limited to traditional shapes such as honeycomb panels or stochastic foams. With this increase in design freedom comes a significant increase in optionality, which can be overwhelming to the designer. This paper aims to provide a framework for thinking about the four key questions in cellular material design: how to select a unit cell, how to vary cell size spatially, what the optimal parameters are, and fina

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24

Rist, Thomas, Róbert Debnár, and Jozef Krišťák. "A Methodology for Cellular Manufacturing Design." Communications - Scientific letters of the University of Zilina 2, no. 1 (2000): 39–44. http://dx.doi.org/10.26552/com.c.2000.1.39-44.

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25

ISOMURA, Tadashi, Tetsuya TOYODA, and Eisuke KITA. "Structural Design Method Using Cellular Automaton." Proceedings of the JSME annual meeting 2000.1 (2000): 147–48. http://dx.doi.org/10.1299/jsmemecjo.2000.1.0_147.

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26

RIBEIRO, J. F. FERREIRA, and B. PRADIN. "A methodology for cellular manufacturing design." International Journal of Production Research 31, no. 1 (1993): 235–50. http://dx.doi.org/10.1080/00207549308956723.

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27

Li, Gang, and Yuan Yao. "Manufacturable Gradient-Variable Cellular Structures Design." IOP Conference Series: Materials Science and Engineering 692 (November 27, 2019): 012010. http://dx.doi.org/10.1088/1757-899x/692/1/012010.

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28

Seiler, G., A. J. Schuler, and J. A. Nossek. "Design of robust cellular neural networks." IEEE Transactions on Circuits and Systems I: Fundamental Theory and Applications 40, no. 5 (1993): 358–64. http://dx.doi.org/10.1109/81.232580.

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29

Kataoka, Kazunori. "Molecular Design of Cellular Specific Polymers." Kobunshi 41, no. 10 (1992): 706–9. http://dx.doi.org/10.1295/kobunshi.41.706.

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30

Schlueter, Arno, and Tobias Bonwetsch. "Design Rationalization of Irregular Cellular Structures." International Journal of Architectural Computing 6, no. 2 (2008): 197–211. http://dx.doi.org/10.1260/147807708785850104.

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31

Shayan, Ebrahim. "Cellular design for injection moulding shop." Computers & Industrial Engineering 35, no. 3-4 (1998): 487–90. http://dx.doi.org/10.1016/s0360-8352(98)00140-5.

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32

ISHIDA, Ryohei, and Megumi SHIRAGAMI. "406 Topological Design by Cellular Automaton." Proceedings of Ibaraki District Conference 2000 (2000): 101–2. http://dx.doi.org/10.1299/jsmeibaraki.2000.101.

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33

Daikoku, K., and H. Ohdate. "Optimal design for cellular mobile systems." IEEE Transactions on Vehicular Technology 34, no. 1 (1985): 3–12. http://dx.doi.org/10.1109/t-vt.1985.24028.

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34

Lubke, Gabriela Pereira, Élcio Cassimiro Alves, and Macksuel Soares de Azevedo. "Optimized design of cellular steel beams." Revista de Estrutura do Aço 6, no. 1 (2017): 1. http://dx.doi.org/10.17648/aco-2238-9377-6-1-1.

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35

KIM, K. "Quantum-Dot Cellular Automata Design Guideline." IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences E89-A, no. 6 (2006): 1607–14. http://dx.doi.org/10.1093/ietfec/e89-a.6.1607.

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36

Tang, Yunlong, and Yaoyao Fiona Zhao. "Multifunctional design of heterogeneous cellular structures." Structural and Multidisciplinary Optimization 58, no. 3 (2018): 1121–38. http://dx.doi.org/10.1007/s00158-018-1956-9.

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37

Seepersad, Carolyn C., Rajesh S. Kumar, Janet K. Allen, Farrokh Mistree, and David L. Mcdowell. "Multifunctional design of prismatic cellular materials." Journal of Computer-Aided Materials Design 11, no. 2-3 (2004): 163–81. http://dx.doi.org/10.1007/s10820-005-3167-0.

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38

Mak, K. L., and Y. S. Wong. "Genetic design of cellular manufacturing systems." Human Factors and Ergonomics in Manufacturing 10, no. 2 (2000): 177–92. http://dx.doi.org/10.1002/(sici)1520-6564(200021)10:2<177::aid-hfm4>3.0.co;2-a.

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39

Nakai, Koji, and Akio Ushida. "Design technique of cellular neural network." Electronics and Communications in Japan (Part III: Fundamental Electronic Science) 78, no. 3 (1995): 97–107. http://dx.doi.org/10.1002/ecjc.4430780309.

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40

Yang, Li. "Experimental-assisted design development for an octahedral cellular structure using additive manufacturing." Rapid Prototyping Journal 21, no. 2 (2015): 168–76. http://dx.doi.org/10.1108/rpj-12-2014-0178.

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Purpose – This paper aims to demonstrate the design and verification of a 3D reticulate octahedral cellular structure using both analytical modeling and additive manufacturing. Traditionally, it has been difficult to develop and verify designs for 3D cellular structures due to their design complexity. Design/methodology/approach – Unit cell modeling approach was used to model the octahedral cellular structure. By applying structural symmetry simplification, the cellular structure was simplified into a representative geometry that could be further designed with a standard beam theory. The verif

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41

Ranjbar, Roohallah, Seyed Ahmad Shayannia, Mehdi Amir Miandargh, and Mohammad Reza Lotfi. "Integrated Design of Cellular Production System Using Branch and Bound Algorithm." Discrete Dynamics in Nature and Society 2022 (July 12, 2022): 1–10. http://dx.doi.org/10.1155/2022/9652547.

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Most research done on the design of cellular production systems also has examined one of the main areas of design including cell formation, cellular layout, and material handling. Some research studies also have been done by considering the lack of independence of these areas, two areas simultaneously, and three areas sequentially. The main goal of this research is to present a mathematical framework for designing and also providing the efficient methods for solving the desired problem. Therefore, the main contribution of this paper is to determine the same component according to the character

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42

Deng, Feifei, Guangjun Xie, Shaowei Wang, Xin Cheng, and Yongqiang Zhang. "An Ultra-Low-Power Five-Input Majority Gate in Quantum-Dot Cellular Automata." Journal of Circuits, Systems and Computers 29, no. 11 (2020): 2050176. http://dx.doi.org/10.1142/s0218126620501765.

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Quantum-dot cellular automata (QCA) is a highly attractive alternative to CMOS for future digital circuit design, relying on its high-performance and low-power-consumption features. This paper analyzes and compares previously published five-input majority gates. These designs do not perform well in terms of physical properties, especially concerting power consumption. Therefore, an ultra-low-power five-input majority gate in one layer is proposed, which uses a minimum number of cells and smaller area, and achieves the expected highly polarized output compared with previous designs. In order to

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43

Sen, Bibhash, Ayush Rajoria, and Biplab K. Sikdar. "Design of Efficient Full Adder in Quantum-Dot Cellular Automata." Scientific World Journal 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/250802.

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Further downscaling of CMOS technology becomes challenging as it faces limitation of feature size reduction. Quantum-dot cellular automata (QCA), a potential alternative to CMOS, promises efficient digital design at nanoscale. Investigations on the reduction of QCA primitives (majority gates and inverters) for various adders are limited, and very few designs exist for reference. As a result, design of adders under QCA framework is gaining its importance in recent research. This work targets developing multi-layered full adder architecture in QCA framework based on five-input majority gate prop

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44

Cheng, Lin, Pu Zhang, Emre Biyikli, Jiaxi Bai, Joshua Robbins, and Albert To. "Efficient design optimization of variable-density cellular structures for additive manufacturing: theory and experimental validation." Rapid Prototyping Journal 23, no. 4 (2017): 660–77. http://dx.doi.org/10.1108/rpj-04-2016-0069.

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Purpose The purpose of the paper is to propose a homogenization-based topology optimization method to optimize the design of variable-density cellular structure, in order to achieve lightweight design and overcome some of the manufacturability issues in additive manufacturing. Design/methodology/approach First, homogenization is performed to capture the effective mechanical properties of cellular structures through the scaling law as a function their relative density. Second, the scaling law is used directly in the topology optimization algorithm to compute the optimal density distribution for

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45

Opgenoord, Max M. J., and Karen E. Willcox. "Design for additive manufacturing: cellular structures in early-stage aerospace design." Structural and Multidisciplinary Optimization 60, no. 2 (2019): 411–28. http://dx.doi.org/10.1007/s00158-019-02305-8.

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46

Khan, Angshuman, and Rohit Shaw. "Design of Multilayered XOR Gate Using Quantum Dot Cellular Automata." Jordan Journal of Electrical Engineering 11, no. 1 (2025): 1. http://dx.doi.org/10.5455/jjee.204-1716825685.

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The rapid advancement of microelectronics technology necessitates the development of high-speed, low-power devices. Quantum Cellular Automaton (QCA) is emerging as a promising technology enabling logic circuits with exceptional operating speeds. The XOR gate is crucial in nanocomputing applications, such as nano-processors and nano-communication units, and requires innovative design approaches. This paper presents a novel design of an XOR gate using a multilayered layout methodology within the QCA framework. The circuit’s design and validation are performed using QCADesigner 2.0.3, while energ

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47

Yang, Li, Ola A. Harrysson, Harvey A. West II, Denis R. Cormier, Chun Park, and Kara Peters. "Low-energy drop weight performance of cellular sandwich panels." Rapid Prototyping Journal 21, no. 4 (2015): 433–42. http://dx.doi.org/10.1108/rpj-08-2013-0083.

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Purpose – The aim of this study is to perform a comparative study on sandwich structures with several types of three-dimensional (3D) reticulate cellular structural core designs for their low-energy impact absorption abilities using powder bed additive manufacturing methods. 3D reticulate cellular structures possess promising potentials in various applications with sandwich structure designs. One of the properties critical to the sandwich structures in applications, such as aerospace and automobile components, is the low-energy impact performance. Design/methodology/approach – Sandwich samples

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48

Almatrood, Amjad F., and Harpreet Singh. "Design of Generalized Pipeline Cellular Array in Quantum-Dot Cellular Automata." IEEE Computer Architecture Letters 17, no. 1 (2018): 29–32. http://dx.doi.org/10.1109/lca.2017.2719021.

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49

TANAKA, Hideyuki, Yoshinobu KAWAHARA, Takehisa YAIRI, and Kazuo MACHIDA. "Design of Cellular Satellites for Reconfigurable Space System Using Orbital Servicing Robots(Hyper Performance Robotics and Mechatronics,Session: TA1-B)." Abstracts of the international conference on advanced mechatronics : toward evolutionary fusion of IT and mechatronics : ICAM 2004.4 (2004): 41. http://dx.doi.org/10.1299/jsmeicam.2004.4.41_1.

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50

Medjmedj, Ayoub, Albert Ngalle-Loth, Rudy Clemençon, Josef Hamacek, Chantal Pichon, and Federico Perche. "In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA." Nanomaterials 12, no. 14 (2022): 2446. http://dx.doi.org/10.3390/nano12142446.

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Abstract:

Lipid Nanoparticles (LNPs) are a leading class of mRNA delivery systems. LNPs are made of an ionizable lipid, a polyethyleneglycol (PEG)-lipid conjugate and helper lipids. The success of LNPs is due to proprietary ionizable lipids and appropriate helper lipids. Using a benchmark lipid (D-Lin-MC3) we compared the ability of three helper lipids to transfect dendritic cells in cellulo and in vivo. Studies revealed that the choice of helper lipid does not influence the transfection efficiency of immortalized cells but, LNPs prepared with DOPE (dioleylphosphatidylethanolamine) and β-sitosterol were

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