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Journal articles on the topic 'Design Consultancy'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Delić, Anamarija, and Mirela Alpeza. "Career switch." Ekonomski vjesnik 36, no. 2 (2023): 349–60. http://dx.doi.org/10.51680/ev.36.2.10.

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Purpose: This paper examines the consultancy process in small and medium-sized enterprises (SMEs), focusing on consulting entrepreneurs at the beginning of their entrepreneurial career chosen out of necessity due to a terminated long-term employment contract in a public company.Methodology: A qualitative study design was adopted to look into the consultancy process with five new entrepreneurs who participated in a program that combined trainings and consultancy sessions. Text analysis of written feedback from consultants was conducted to understand the challenges entrepreneurs faced and progre

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Dewah, Peterson. "Records management consultancy service in Zimbabwe: The consultants’ view." Journal of Librarianship and Information Science 50, no. 1 (2016): 68–76. http://dx.doi.org/10.1177/0961000616664399.

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This article reports the results of a study aimed at establishing the records consultants’ views on records management consultancy services in the Zimbabwean information society. The participants included three records consultancy companies and nine archivists who were purposively sampled. Using a qualitative exploratory study design data were gathered through interviews. The results suggest that there are a plethora of records management problems in both public and private sectors and concludes that the prevailing economic situation is hampering records management consultancy such that organi

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Berry, Donald, Kristine Broglio, Carol Ward, et al. "Patient-Level Meta-Analysis of End-of-Therapy PET-CR as a Surrogate Endpoint for PFS and OS in Patients with Previously Untreated DLBCL: Implications for Clinical Trial Design." Blood 134, Supplement_1 (2019): 4101. http://dx.doi.org/10.1182/blood-2019-124067.

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Introduction: The use of PET-CR as a surrogate endpoint would expedite the development of novel therapies and enable better estimates of sample size based on early outcomes of a trial. Previous studies have reported an association between end-of-therapy (EOT) PET results and long-term progression-free (PFS) and overall survival (OS) in diffuse large B-cell lymphoma (DLBCL) patients receiving standard first-line chemoimmunotherapy. We have also previously shown that the overall predictability of PET-CR for PFS and OS in these trials is similar to that in 18 literature-based studies. (15-ICML 20

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Kindl, Eva-Maria, and Beatriz Casais. "Motivations and perceived opportunities for partnerships among international business consultancy firms." Review of International Business and Strategy 29, no. 4 (2019): 315–28. http://dx.doi.org/10.1108/ribs-02-2019-0024.

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Purpose Consultancy services for internationalisation are crucial to help companies to grow and find new businesses abroad. This kind of service used to be provided by consultancy firms operating in the home country of the clients. Considering the advantages of partnerships that theory has enhanced, this paper aims to identify the motivations and perceived opportunities from consultancy firms to establish business-to-business partnerships with international consultancy companies in other countries, with the purpose of reinforcing international trading. Design/methodology/approach As an explora

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Lai, Michael T., and Hsien-Hui Tang. "Shifting the Value of Experience." Cubic Journal 6, no. 6 (2023): 76–97. http://dx.doi.org/10.31182/cubic.2023.6.62.

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This paper is a reflection of the evolution of a user experience (UX) consultancy's transformation into a brand experience consultancy in an increasingly competitive market in China. As part of this transformation, the value of design has shifted from tactical to strategic. The authors compare and contrast the nature of experience design and experience strategy and how they are delivered to close the gap between designers and strategists. While this paper serves as a case study of one consultancy in China, the lessons, knowledge, and understanding gained are applicable to the user experience i

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Behsan, Hossein, and Vahid Shahhosseini. "Legal and contractual foundations of intellectual property of design of construction projects." International Journal of Engineering & Technology 3, no. 3 (2014): 290. http://dx.doi.org/10.14419/ijet.v3i3.2689.

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Viable improvement of any complex in micro and macro scales requires producing novel plans and having the complex to make use of innovative technologies and findings. In most developmental projects, the project consultants are responsible for producing plans and for directing the projects towards providing the opportunity to make use of the mentioned facilities. The beneficiaries' interests are considered as one of the issues to be considered while producing and directing plans. The interests of the projects' consultants include material and intellectual property of the plans made. Because som

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Owusu-Manu, De-Graft, David John Edwards, Michael Adesi, Edward Badu, and Peter E. D. Love. "Attaining fairness in construction cost consultancy pricing services." Journal of Engineering, Design and Technology 14, no. 4 (2016): 699–712. http://dx.doi.org/10.1108/jedt-01-2015-0002.

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Purpose Price fairness is important amongst construction and engineering consultants because a perceived lack of it engenders unwillingness to pay amongst clients. This can create contractual disputes that negatively impact upon a consultant’s ability to generate sufficient revenue to ensure business continuity and survival. With this in mind, this research aims to analyse the pricing measurement forces needed to attain pricing fairness within a Ghanaian construction cost consultancy practice. Specific objectives are to identify the key variables responsible for price fairness within cost cons

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Shaw, David. "Partners and plagiarisers: dualities in consultants’ influence on organisational change projects." Journal of Organizational Change Management 32, no. 1 (2019): 51–66. http://dx.doi.org/10.1108/jocm-01-2018-0011.

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Purpose The purpose of this paper is to examine the interplay between the requirements for successful organisational change and the imperatives faced by management consultancy firms in running successful businesses, and how this interplay affects the ways in which management consultants influence organisational change projects. Design/methodology/approach The paper reviews literature on management consultancy and organisational change over the past 30 years to identify insights into this issue. Findings The paper shows that business imperatives faced by management consultancy firms affect the

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Zakariah, Habiel, Nadhratunnaim Nasarudin, and Ariff Azly Muhamed. "Enhancing Building Information Management Adoption in Design Consultant Companies in Malaysia: A Conceptual Study." International Journal of Research and Innovation in Social Science VIII, no. XIV (2024): 1–4. http://dx.doi.org/10.47772/ijriss.2024.814mg001.

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The implementation of a Building Information Modelling (BIM) system has been acknowledged to offer numerous advantages to a design consultancy organization. Nevertheless, an examination of a readiness study on design consultant firms regarding the implementation of BIM System reveals a negligible adoption rate within the industry. Therefore, further endeavors are necessary to promote a more widespread utilization of BIM. The objective of this research is to encourage the extensive implementation of BIM in the consultant organization. The research objective is to investigate the potential benef

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Nachalwe, Chipampe Mercy, and Osward Bwanga. "Impact and challenges of consultancy role regarding the delivery of breast imaging services in the United Kingdom: consultant breast radiographers' perspective." Medical Journal of Zambia 48, no. 1 (2021): 46–53. http://dx.doi.org/10.55320/mjz.48.1.54.

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Background: Breast cancer is the leading cause of death in women worldwide. Imaging and radiographers play an important role in the diagnosis and treatment of breast cancer. With the increase in demand and a shortage of radiologists in the UK, consultant breast radiographers were introduced to perform some roles previously performed by radiologists. However, there is a scarcity of researchto assist other countries, such as Zambia, who are planning to extend the role of radiographers.Objective: To explore the impact and challenges of the radiography consultancy role regarding the delivery of br

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Sokol, Marc B. "Mindful design of the sole-practitioner consultancy." Consulting Psychology Journal: Practice and Research 72, no. 1 (2020): 27–39. http://dx.doi.org/10.1037/cpb0000153.

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Grylls, Bethan. "The Growing Role of the Design Consultancy." New Electronics 52, no. 2 (2019): 10. http://dx.doi.org/10.12968/s0047-9624(22)60882-4.

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Soares, João, Fernando Romero, and Manuel Lopes Nunes. "Understanding the Roles of Private Consultants as Innovation Intermediaries in Technology Transfer: A Case Study in the Portuguese National Innovation System." Journal of Innovation Management 12, no. 3 (2024): 56–71. https://doi.org/10.24840/10.24840/2183-0606_012.003_0003.

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The fields of innovation systems and technology transfer (TT) have seen growing interest in recent years, especially in the context of open innovation. Private consultants, play a vital role in mediating and facilitating interactions among various stakeholders in the innovation process. However, the specific roles of private consultants as innovation intermediaries have received limited attention in the literature. This study presents a case analysis of a Portuguese consultancy firm involved in 219 TT projects between 2015 and 2021. The research identifies six key intermediary roles consistent

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Soares, João, Fernando Romero, and Manuel Lopes Nunes. "Understanding the Roles of Private Consultants as Innovation Intermediaries in Technology Transfer: A Case Study in the Portuguese National Innovation System." Journal of Innovation Management 12, no. 3 (2024): 56–71. https://doi.org/10.24840/2183-0606_012.003_0003.

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The fields of innovation systems and technology transfer (TT) have seen growing interest in recent years, especially in the context of open innovation. Private consultants, play a vital role in mediating and facilitating interactions among various stakeholders in the innovation process. However, the specific roles of private consultants as innovation intermediaries have received limited attention in the literature. This study presents a case analysis of a Portuguese consultancy firm involved in 219 TT projects between 2015 and 2021. The research identifies six key intermediary roles consistent

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Nachalwe, Mercy Chipampe, and Osward Bwanga. "Impact and challenges of consultancy role regarding the delivery of breast Imaging services in the United Kingdom: consultant breast radiographers’ perspective." Medical Journal of Zambia 48, no. 1 (2021): 46–53. http://dx.doi.org/10.55320/mjz.48.1.748.

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BACKGROUND: Breast cancer is the common and leading cause of death in women worldwide. Imaging and radiographers play an important role in the diagnosis and treatment of breast cancer. With the increase in demand and shortage of radiologists in the UK, consultant breast radiographers were introduced to perform some roles previously performed by radiologists. However, there is scarcity of research to assist other countries, such as Zambia who are planning to extend the role of a radiographer. OBJECTIVE: To explore the impact and challenges of consultancy role regarding the delivery of bre

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Gan, Yifan. "Meet the AI expert." Touchpoint 15, no. 1 (2024): 78–80. http://dx.doi.org/10.30819/touchpoint.15-1.18.

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In this interview, Touchpoint Editor-in-Chief Jesse Grimes interviews Yifan Gan, a Shanghai-based consultant working at the intersection of service design and AI, and a Guest Editor of thisissue of Touchpoint. In addition to his consultancy work assisting Chinese firms with AI strategy and implementation, he is a lecturer for TongJi University and Shanghai Jiaotong University in service design and strategy.

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Wesson, Christopher. "Cartographic Design, Quality and Consultancy at Ordnance Survey." Cartographic Journal 44, no. 3 (2007): 209–15. http://dx.doi.org/10.1179/000870407x241728.

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Sporrong, Josefin. "Criteria in consultant selection: public procurement of architectural and engineering services." Construction Economics and Building 11, no. 4 (2011): 59–76. http://dx.doi.org/10.5130/ajceb.v11i4.2297.

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The competence, commitment and attitudes of design consultants strongly influence the quality and costs of built facilities. However, in the selection of professional services it is often difficult to specify and assess non-price criteria related to both firms and individual consultants. Therefore, clients traditionally rely on long term relations or recommendations from clients or colleagues. Public procurement regulation, however, restricts the use of such informal data. This study seeks to understand how procurers act to reconcile these conflicting demands.An explorative questionnaire surve

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Matthias, Olga. "The ‘World’s Newest Profession’ is no Longer Dispensable; What Does it Mean for Consultancy Firms?" Management Consulting Journal 1, no. 1 (2018): 16–27. http://dx.doi.org/10.2478/mcj-2018-0003.

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Abstract A major focus for consultants is pipeline. Generating future work is as important as delivering current projects because it provides continuity and hopefully growth of the business. This inherent uncertainty in the sales pipeline is perhaps the consulting firms’ biggest concerns. This paper seeks to demonstrate how management consultancy has actually become widespread and embedded in the economic activity of organisations. The research synthesised in this paper presents client perspectives on how consultants add value. Particular insight is given into the key features which differenti

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Cornely, Oliver, Anthony Mato, Tadeusz Robak, Sibylle Mellinghoff, and Tatiana Lavrova. "The Prosid Study: Evaluating Efficacy and Safety of Intravenous Immunoglobulin (IVIG) 10% in Primary Infection Prophylaxis in Patients with Chronic Lymphocytic Leukemia- Study Design." Blood 136, Supplement 1 (2020): 20–21. http://dx.doi.org/10.1182/blood-2020-136898.

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Introduction: Secondary immunodeficiency (SID) occurs, among other reasons, as a consequence of hematological malignancies (HM), most commonly in chronic lymphocytic leukemia (CLL) and multiple myeloma. About 25% of patients present with secondary immune deficiency (SID) at diagnosis of CLL and this incidence may increase to 85% during the course of disease. This increase is also due to recent advances in CLL therapy leading to cumulative immunosuppression. Infections are the main cause of morbidity and mortality in CLL patients, causing between 30% and 50% of deaths within the first year afte

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Soler González, Rafael Humberto, and Narda Navarro Mosquera. "The management consultancy as vector of the innovation." Revista Metropolitana de Ciencias Aplicadas 3, no. 2 (2020): 16–27. http://dx.doi.org/10.62452/nzefk048.

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The objective of this work is to investigate the particularities of a business consultancy and take as a case the design of a strategic planning using different tools and models that are part of the style and competence of the consultant who executes the process of technology transfers in pos of improving the administration of a company. The article is elaborated from the vision of a consultant who will design and implement strategic planning and exposes a methodology that emphasizes network theory and other tools to minimize intangibilities while still taking into account the academic princip

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Connolly, Anna, and Anne Matthews. "Exploring Breastfeeding Mothers’ and Lactation Consultants’ Experiences of Lactation Consultancy Throughout the Restrictions Put in Place Due to the COVID-19 Pandemic." HRB Open Research 7 (December 16, 2024): 9. https://doi.org/10.12688/hrbopenres.13856.2.

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Background Breastfeeding rates in Ireland are among the lowest in the world. Lactation consultancy provides mothers with support and information on how to cope with any challenges they encounter. There is emerging evidence that COVID-19 restrictions impacted access to and the quality of breastfeeding support. The aim of this study was to explore breastfeeding mothers’ and lactation consultants’ experiences of breastfeeding support throughout the COVID-19 restrictions in Ireland. It also aimed to explore what adaptations had to be made to the delivery of lactation consultancy and how these chan

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Connolly, Anna, and Anne Matthews. "Exploring Breastfeeding Mothers’ and Lactation Consultants’ Experiences of Lactation Consultancy Throughout the Restrictions Put in Place Due to the COVID-19 Pandemic." HRB Open Research 7 (February 19, 2024): 9. http://dx.doi.org/10.12688/hrbopenres.13856.1.

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Background Breastfeeding rates in Ireland are among the lowest in the world. Lactation consultancy provides mothers with support and information on how to cope with any challenges they encounter. There is emerging evidence that COVID-19 restrictions impacted access to and the quality of breastfeeding support. The aim of this study was to explore breastfeeding mothers’ and lactation consultants’ experiences of breastfeeding support throughout the COVID-19 restrictions in Ireland. It also aimed to explore what adaptations had to be made to the delivery of lactation consultancy and how these chan

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Palladini, Giovanni, Stefan O. Schönland, Suzanne Lentzsch, et al. "OP201: A Phase 1/2 Study of Melflufen and Dexamethasone in Patients with Immunoglobulin Light Chain (AL) Amyloidosis." Blood 134, Supplement_1 (2019): 3163. http://dx.doi.org/10.1182/blood-2019-124244.

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Background: AL amyloidosis is a rare life-threatening disease arising from a disorder of plasma cells resulting in excessive immunoglobulin free light chains (FLC) that are misfolded, aggregate, and form toxic deposits in vital organs including the heart, kidneys, and liver (Merlini G, et al. Nat Rev Dis Primers. 2018). The primary goal of therapy is to reduce or eliminate the FLC and halt the progression of organ damage and improve function. Measures that can improve hematologic responses may improve organ responses and impact survival. Treatments used in other plasma cell disorders, like mul

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Xiang, Chen, and Bum-Kyu Kang. "New Role of Designer's Value through Design Consultancy Developing." Journal of the Korea Contents Association 10, no. 9 (2010): 232–42. http://dx.doi.org/10.5392/jkca.2010.10.9.232.

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Warburton, Nina, Gus Desbarats, and Ian Hosking. "Developing inclusive design expertise within a client/consultancy relationship." Applied Ergonomics 46 (January 2015): 274–78. http://dx.doi.org/10.1016/j.apergo.2013.03.010.

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Lambrev, Veselina S. "Consultancy Communities of Practice." Impacting Education: Journal on Transforming Professional Practice 8, no. 4 (2023): 11–19. http://dx.doi.org/10.5195/ie.2023.331.

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The last two decades have witnessed an ongoing effort to re-design the education doctorate to prepare practitioners to conduct research as a key aspect of their practice. As part of the reform, Carnegie Project on the Education Doctorate (CPED) members have tried to ensure the delivery of a relevant practice-based curriculum that prepares practitioners to respond to local needs. This article examines how one U.S. EdD program uses a practice-based pedagogy, called the Group Consultancy Project, to develop students as scholarly practitioners, that is, educational leaders who conduct research to

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Bouwmeester, Onno, and Jelmer Stiekema. "The paradoxical image of consultant expertise: a rhetorical deconstruction." Management Decision 53, no. 10 (2015): 2433–56. http://dx.doi.org/10.1108/md-11-2014-0653.

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Purpose – The purpose of this paper is to explore the paradoxical image of consultants as “experts without expertise.” It examines the extent to which different stakeholders’ perceptions of consultants’ expertise are aligned, and why. Design/methodology/approach – This research applies a creative approach to survey methodology by asking different stakeholder groups to react to consultancy expertise cartoons. This is followed by a rhetorical interpretation of the perceptions of consultants’ expertise using pathos. Findings – This survey revealed that employees are the most critical of consultan

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Säde, Simo. "Towards User - Centred Design: A Method Development Project in a Product Design Consultancy." Design Journal 4, no. 3 (2001): 20–32. http://dx.doi.org/10.2752/146069201789389566.

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Adesi, Michael, De-Graft Owusu-Manu, and Roisin Murphy. "Strategic competences for pricing quantity surveying consultancy services." Engineering, Construction and Architectural Management 25, no. 3 (2018): 458–74. http://dx.doi.org/10.1108/ecam-12-2016-0264.

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Purpose Professional quantity surveying (QS) services are critical to successful delivery of construction projects within planned budget, quality and duration. The supply of QS professional services is largely dependent on the price level of services and the willingness of clients to pay. The pricing of professional QS consultancy services has been confronted with a myriad of pricing challenges due to rapid changes in the business environment; the pervasive influence of information technology; and the complexity of clients’ expectation. It is therefore necessary for QS consultancy firms to dev

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Marzouk, M., I. Bakry, and M. El-Said. "Assessing design process in engineering consultancy firms using lean principles." SIMULATION 88, no. 12 (2012): 1522–36. http://dx.doi.org/10.1177/0037549712459772.

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The aim of this research is to provide a tool for assessing the impact of applying lean principles to the design process at construction consultancy firms. Through several interviews, a comprehensive model was built to simulate the design process, using data from a leading consultancy firm in Egypt. The model contains the main processes and activities that form different phases of the design process and depicts the interconnectivity of processes and activities needed to create a complete design package upon client request. The research describes how the five main lean principles are integrated

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Er, Özlem. "Nature of Design Consultancy Work for Newly Industrialized Country Clients." Design Journal 1, sup1 (1997): 30–40. http://dx.doi.org/10.2752/146069297790219440.

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Kutaula, Prashant Singh. "Funcastle: Creating a Business Opportunity from a Design Consultancy Assignment." Design Management Review 19, no. 3 (2010): 23–29. http://dx.doi.org/10.1111/j.1948-7169.2008.tb00125.x.

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Johnsen, Jill M., Sarah Ruuska, Peter A. Kouides, and Barbara A. Konkle. "Design of the Von Willebrand Factor in Pregnancy (VIP) Study." Blood 136, Supplement 1 (2020): 29. http://dx.doi.org/10.1182/blood-2020-137738.

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Background: von Willebrand factor (VWF) and factor VIII (FVIII) levels rise during healthy pregnancy by approximately 200 - 250%. VWF increases are markedly less pronounced or absent in pregnant women with von Willebrand disease (VWD). Women with VWD have relatively high rates of postpartum hemorrhage (PPH), even with VWD-specific treatment. Current guidance provides general recommendations for bleeding prophylaxis for childbirth for women with VWD. However, this guidance has been largely based on non-pregnant treatments and does not specify target VWF levels or duration of VWF replacement or

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Streule, Mike, Luke McCrone, Yasmin Andrew, and Craig Walker. "Engaging with students as partners in education-space design." International Journal for Students as Partners 6, no. 2 (2022): 79–90. http://dx.doi.org/10.15173/ijsap.v6i2.5024.

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Engaging with Students as Partners (SaP) in areas of curriculum design and pedagogic consultancy is relatively well established. Here we present a case study of two recent projects at Imperial College London, a research-intensive science, technology, engineering, mathematics, and medicine (STEMM) university, that have extended the SaP model to the design and delivery of modifications to education spaces. Using a research-informed approach and tested method ensured that the students remained active throughout the “twists and turns” of the project, rather than the more traditional snapshot stude

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Brady, Roseanna, Judit Varkonyi-Sepp, and Jemma Byrne. "Consultancy case study: Piloting online group reflective practice for health professionals during the coronavirus pandemic." Health Psychology Update 30, no. 1 (2021): 41–51. http://dx.doi.org/10.53841/bpshpu.2021.30.1.41.

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This case study describes a consultancy project which included providing advice and piloting an intervention to provide psychological support to UK health professionals during the coronavirus pandemic. In April 2020, a health charity requested advice from the Health Psychology Exchange (HPX) on implementing reflective practice for health professionals. One health psychology consultant, supported by HPX colleagues, advised the charity to pilot online group reflective practice, negotiated with the client, and contracted to design, deliver, and evaluate the pilot. The pilot was informed by a rapi

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Westervelt, Peter, Gail J. Roboz, Jorge E. Cortes, et al. "Phase 1 First-in-Human Trial of AMV564, a Bivalent Bispecific (2x2) CD33/CD3 T-Cell Engager, in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML)." Blood 132, Supplement 1 (2018): 1455. http://dx.doi.org/10.1182/blood-2018-99-111529.

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Abstract Background: AMV564 is a novel bivalent, bispecific (2x2) CD33/CD3 targeted immunotherapy that binds both CD33 and the invariant CD3ε on T-cell receptors with strong avidity, thus creating an immune synapse between CD33-expressing cells and T cells, initiating T-cell directed lysis of CD33 expressing cells, and inducing expansion, differentiation and proliferation of T cells. By design, AMV564 has reduced clearance and therefore has a longer half-life (t1/2) than monovalent, bispecific T-cell engagers. In preclinical investigations using both leukemic cell lines and primary cells from

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Gangemi, V., R. Malanga, and P. Ranzo. "Environmental management of the design process. Managing multidisciplinary design: the role of environmental consultancy." Renewable Energy 19, no. 1-2 (2000): 277–84. http://dx.doi.org/10.1016/s0960-1481(99)00041-5.

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Richardson, Paul G., Ruben Niesvizky, Jay Yang, Neelu Yadav, Helen Hsu, and Christopher R. Flowers. "A Phase 1/1b Open-Label, Multicenter, Two-Part Study of SETD2 Inhibitor EZM0414 in Patients with Relapsed/Refractory Multiple Myeloma or Diffuse Large B-Cell Lymphoma." Blood 138, Supplement 1 (2021): 1679. http://dx.doi.org/10.1182/blood-2021-147967.

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Abstract Background: Multiple myeloma (MM) is a heterogeneous disease of monoclonal plasma cells. More than 40% of patients with MM harbor translocations of the immunoglobulin heavy chain (IGH) gene on chromosome 14, leading to overexpression of putative oncogenes which can ultimately lead to plasma cell-derived, post-malignancy MM. One such translocation, t(4;14), is seen in 15% of patients and juxtaposes IGH control elements with two genes on chromosome 4, FGFR3 and MMSET. Patients harboring the (4;14) translocation have a poor response to standard of care therapies and an overall poor progn

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Hay, Annette E., Sarit Assouline, Roland B. Walter, et al. "Accrual Barriers and Detection of Early Toxicity Signal in Older Less-Fit Patients Treated with Azacitidine and Nivolumab for Newly Diagnosed Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS) in the SWOG 1612 Platform Randomized Phase II/III Clinical Trial." Blood 134, Supplement_1 (2019): 3905. http://dx.doi.org/10.1182/blood-2019-124320.

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Background: Less-fit patients with acute myeloid leukemia (AML) or high-risk myelodysplasia (MDS) age 60 years and older constitute the majority of patients with AML/MDS but are not well represented in clinical trials. DNA-methyltransferase inhibitor (HMA) monotherapy (e.g. azacitidine or decitabine) is usual. Overall response rates (ORR) are low; improvement in overall survival relative to supportive care alone is modest, highlighting the critical need for efficient identification of effective novel therapies. Blocking programed cell death protein-1 (PD-1) signaling with nivolumab may increas

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Daver, Naval G., Pau Montesinos, Daniel J. DeAngelo, et al. "A Phase I Study of IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate, in Patients with Relapsed/Refractory Acute Myeloid Leukemia, Blastic Plasmacytoid Dendritic Cell Neoplasm, and Other CD123-Positive Hematologic Malignancies." Blood 134, Supplement_1 (2019): 1334. http://dx.doi.org/10.1182/blood-2019-128275.

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Background: Overexpression of CD123, the alpha subunit of the IL-3 receptor, occurs in multiple hematological malignancies, including acute myeloid leukemia (AML), blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute lymphoblastic leukemia (ALL) and others, thus making this antigen an attractive target for the development of new therapeutics. IMGN632 is a CD123-targeting antibody-drug conjugate (ADC) comprising a novel anti-CD123 antibody coupled, via a peptide linker, to a unique DNA-alkylating cytotoxic payload of the recently developed IGN (indolinobenzodiazepine pseudodimer) class.

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Ghobadi, Armin, Ibrahim Aldoss, Frederick L. Locke, et al. "A Phase 1/2 Dose-Escalation and Dose-Expansion Study of the Safety and Efficacy of Anti-CD7 Allogeneic CAR-T Cells (WU-CART-007) in Patients with Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)/ Lymphoblastic Lymphoma (LBL)." Blood 138, Supplement 1 (2021): 4829. http://dx.doi.org/10.1182/blood-2021-146841.

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Abstract Background T-ALL/LBL represent a class of devastating hematologic cancers with high rates of relapse and mortality in both children and adults. Despite intensive multi-agent chemotherapy regimens, fewer than 50% of adults and 85% of children with T-ALL survive beyond five years. For those who relapse after initial therapy, salvage regimens induce remissions in only ~20-30% of cases, and survival is dismal. T-ALL/LBL is a genetically diverse group, but with universal overexpression of CD7, making this a suitable target for immunotherapy. Despite the success of CAR-T cells in B-cell mal

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Daver, Naval G., Harry P. Erba, Nikolaos Papadantonakis, et al. "A Phase 1b/2 Study of the CD123-Targeting Antibody-Drug Conjugate IMGN632 As Monotherapy or in Combination with Venetoclax and/or Azacitidine for Patients with CD123-Positive Acute Myeloid Leukemia." Blood 134, Supplement_1 (2019): 2601. http://dx.doi.org/10.1182/blood-2019-128501.

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Background: Overexpression of CD123, the alpha subunit of the IL-3 receptor, is characteristic of a number of hematological malignancies, including acute myeloid leukemia (AML), thus providing an attractive candidate for targeted therapeutic approaches in this disease. IMGN632 is a CD123-targeting antibody-drug conjugate (ADC) comprising a novel anti-CD123 antibody coupled, via a peptide linker, to a unique DNA-alkylating payload of the recently developed IGN (indolinobenzodiazepine pseudodimer) class of cytotoxic compounds. Preclinically, IMGN632 exhibited potent antitumor tumor activity, wit

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Krishnan, Amrita, Prashant Kapoor, Joycelynne Palmer, et al. "A Phase I/II Trial of Ixazomib (Ix), Pomalidomide (POM), and Dexamethasone (DEX), in Relapsed/Refractory (R/R) Multiple Myeloma (MM) Patients: Responses in Double/Triple Refractory Myeloma and Poor Risk Cytogenetics." Blood 128, no. 22 (2016): 3316. http://dx.doi.org/10.1182/blood.v128.22.3316.3316.

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Abstract Triplet regimens combining an immunomodulatory agent, a proteasome inhibitor (PI), and a steroid are used to treat newly diagnosed and relapsed multiple myeloma (MM). Although ixazomib (Ix), an oral PI with single agent activity, can be combined with lenalidomide (LEN), patients (pts) with relapsed/refractory (R/R) MM are often LEN-refractory. Pomalidomide (POM) has single agent activity in LEN-refractory disease, and both POM and Ix also show activity in poor cytogenetic risk pts. Methods: Primary objectives: 1) determine the maximum tolerated dose (MTD) of Ix in combination with sta

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Becker, Marie N., Alexandra Howson, Timothy A. Quill, Naval Daver, and Eytan M. Stein. "Practice Gaps and Barriers in Optimal Care Among Healthcare Providers Treating Patients with Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML): Results of a Two-Phase Qualitative/Quantitative Study." Blood 138, Supplement 1 (2021): 1944. http://dx.doi.org/10.1182/blood-2021-151714.

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Abstract Background: Rapid advances in the understanding of the biology of MDS and AML have led to novel therapeutic interventions that have increased the clinical complexity of decision making in patient care. This study sought to quantify professional practice gaps and barriers to optimal care among healthcare providers treating patients with MDS and AML at academic medical centers and/or community cancer centers and clinics globally, with the goal of informing the design of evidence-based education interventions aiming at addressing these gaps. Methods: In February-May 2021, 329 physicians

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Daver, Naval, Kyoo Hyung Lee, Chul Won Jung, et al. "HM43239, a Novel Small Molecule Inhibitor of FLT3, in Acute Myeloid Leukemia (AML) with and without FMS-like Tyrosine Kinase 3 (FLT3) Mutations: Phase 1/2 Study." Blood 136, Supplement 1 (2020): 1. http://dx.doi.org/10.1182/blood-2020-143244.

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Background: FLT3 mutations, found in ~30% of patients with AML, and are associated with a poor prognosis. HM43239 is a novel FLT3 inhibitor that potently inhibits not only FLT3 mutants, including ITD and TKD mutants and FLT3 wild type but also spleen tyrosine kinase (SYK). Its dual inhibition of both FLT3 and SYK may activity in AML. In preclinical studies, HM43239 showed more potent activity than Gilteritinib in FLT3-WT/ITD heterozygous MOLM-13/-14 AML cell models. Furthermore, HM43239 showed potent antileukemia activity in xenograft models of FLT3-ITD/F691L cell lines harboring double mutati

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Roboz, Gail J., Daniel J. DeAngelo, David A. Sallman, et al. "Ameli-01: Phase I, Open Label Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Expansion, Persistence and Clinical Activity of UCART123 (allogeneic engineered T-cells expressing anti-CD123 chimeric antigen receptor), Administered in Patients with Relapsed/Refractory Acute Myeloid Leukemia." Blood 136, Supplement 1 (2020): 41–42. http://dx.doi.org/10.1182/blood-2020-138984.

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Background: Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with an incidence that increases with age, and a generally poor prognosis. The prognosis remains especially grim for those who are older, have secondary AML, or relapsed or refractory (R/R) disease, in which 5-year OS is 5-10%. Therefore, novel therapeutic approaches are needed. CD123(IL3Rα) is a cell surface target that is expressed on normal, committed hematopoietic progenitor cells, and a variety of hematological neoplasms, including AML, myelodysplastic syndrome (MDS), and blastic plasmacytoid den

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Muehlemann, Natalia, Rajat Mukherjee, Ali T. Taher, Thordis Gudmundsdottir, Isabelle Morin, and Frank Richard. "Innovative Adaptive Study Design in Transfusion-Dependent Beta-Thalassemia: Bayesian Design with Concurrent Randomization and Borrowing from Historical Data." Blood 138, Supplement 1 (2021): 4160. http://dx.doi.org/10.1182/blood-2021-146512.

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Abstract Background Clinical development of new therapies in transfusion-dependent beta-thalassemia has several challenges. Patient enrollment in rare diseases requires multi-center multi-country studies, and the lack of reliable surrogate endpoint for dose selection requires powering for clinical endpoints usually used in Phase 3 trials. An acceptable endpoint from a regulatory perspective which is based on responders analysis, such as proportion of patients experiencing ≥50% reduction in Red Blood Cell (RBC) transfusion burden and a reduction of ≥2 units, requires 12 weeks screening period t

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Wong, Lilly, Manisha Lamba, María Dolores Jiménez Nuñez, et al. "Dose- and Schedule-Dependent Immunomodulatory Effects of the Novel Celmod Agent CC-92480 in Patients with Relapsed/Refractory Multiple Myeloma." Blood 136, Supplement 1 (2020): 47–48. http://dx.doi.org/10.1182/blood-2020-137161.

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Introduction: CC-92480 is an oral novel cereblon (CRBN) E3 ligase modulator (CELMoD) agent currently in phase 1/2 development in patients with relapsed/refractory multiple myeloma (RRMM). CC-92480 induces rapid degradation of the transcription factors Ikaros and Aiolos, leading to apoptosis of myeloma cells and immune-stimulatory effects. The innovative CC-92480-MM-001 phase 1 study design investigated the effects of a broad range of CC-92480 doses and schedules. The pharmacodynamic effects will be discussed in this analysis with a focus on modulation of immune cell subsets. Methods: An adapti

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Flowers, Christopher R., Carlos Panizo, Iris Isufi, et al. "Long Term Follow-up of a Phase 2 Study Examining Intratumoral G100 Alone and in Combination with Pembrolizumab in Patients with Follicular Lymphoma." Blood 132, Supplement 1 (2018): 2892. http://dx.doi.org/10.1182/blood-2018-99-117932.

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Abstract Background: Despite numerous treatment (Tx) options, follicular lymphoma (FL) remains incurable, and established common treatments such as chemoimmunotherapy combinations and kinase inhibitors can have significant morbidity, especially in older patients or in those with comorbidities. G100 is a TLR4 (toll-like receptor 4) agonist that activates both the innate and adaptive arms of the immune system. When given intratumorally (IT), G100 triggers an anti-tumor immune response that leads to systemic tumor shrinkage (Flowers ASCO 2017). Initial data from a randomized study of the combinat

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