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Paik, Sangwook. "Multi-objective optimal design of steel trusses in unstructured design domains." Thesis, Texas A&M University, 2005. http://hdl.handle.net/1969.1/3124.
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Researchers have applied genetic algorithms (GAs) and other heuristic optimization methods to perform truss optimization in recent years. Although a substantial amount of research has been performed on the optimization of truss member sizes, nodal coordinates, and member connections, research that seeks to simultaneously optimize the topology, geometry, and member sizes of trusses is still uncommon. In addition, most of the previous research is focused on the problem domains that are limited to a structured domain, which is defined by a fixed number of nodes, members, load locations, and load magnitudes. The objective of this research is to develop a computational method that can design efficient roof truss systems. This method provides an engineer with a set of near-optimal trusses for a specific unstructured problem domain. The unstructured domain only prescribes the magnitude of loading and the support locations. No other structural information concerning the number or locations of nodes and the connectivity of members is defined. An implicit redundant representation (IRR) GA (Raich 1999) is used in this research to evolve a diverse set of near-optimal truss designs within the specified domain that have varying topology, geometry, and sizes. IRR GA allows a Pareto-optimal set to be identified within a single trial. These truss designs reflect the tradeoffs that occur between the multiple objectives optimized. Finally, the obtained Pareto-optimal curve will be used to provide design engineers with a range of highly fit conceptual designs from which they can select their final design. The quality of the designs obtained by the proposed multi-objective IRR GA method will be evaluated by comparing the trusses evolved with trusses that were optimized using local perturbation methods and by trusses designed by engineers using a trial and error approach. The results presented show that the method developed is very effective in simultaneously optimizing the topology, geometry, and size of trusses for multiple objectives.
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Anderson, Janet E. "Sonification design for complex work domains : streams, mappings and attention /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18173.pdf.
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Zhang, Yanyan. "Investigation of SH2 Domains: Ligand Binding, Structure and Inhibitor Design." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1259766230.
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Nicholas, Paul, and not supplied. "Approaches to Interdependency: early design exploration across architectural and engineering domains." RMIT University. Architecture and Design, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20081204.151243.
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While 3D digital design tools have extended the reach of architectural and engineering designers within their own domains, restrictions on the use of the tools and an approach to practice whereby the architect designs (synthesises) and the engineer solves (analyses) - in that order ¡V have limited the opportunities for interdependent modes of interaction between the two disciplines during the early design phase. While it is suggested that 3D digital design tools can facilitate a more integrated approach to design exploration, this idea remains largely untested in practice. The central proposition of my research is that that 3D digital tools can enable interdependencies between crucial aspects of architectural and engineering design exploration during the early design phase which, before the entry of the computer, were otherwise impossible to affect. I define interdependency as a productive form of practice enabled by mutual and lateral dependence. Interdependent parties use problem solving processes that meet not only their own respective goals, but also those of others, by constructively engaging difference across their boundaries to actively search for solutions that go beyond the limits of singular domains. Developed through practice-based project work undertaken during my 3 year postgraduate internship within the Melbourne Australia office of the engineering firm Arup, my research explores new and improved linkages between early design exploration, analysis and making. The principal contribution of my research is to explore this problem from within the context, conditi ons and pressures of live practice. To test the research proposition this dissertation engages firstly with available literature from the fields of organisation theory and design, secondly with information gathered from experts in the field principally via interview, and lastly with processes of testing through practice-based (as opposed to university-based) project work. The dissertation is organized as follows: The Introductory Chapter outlines the central hypothesis, the current state of the discourse, and my motivations for conducting this research. I summarise the structure of my research, and the opportunities and limitations that have framed its ambitions. Chapter Two, Approach to Research and Method, details the constraints and possibilities of the Embedded Research within Architectural Practice context, within which this work has been undertaken, and describes the Melbourne office of Arup, the practice with whom I have been embedded. These contexts have led to the selection of a particular set of ethnographic research instruments, being the use of semi-structured interviews and the undertaking of practice-based studies as a participant-observer. These modes of testing are explained, and the constraints, limitations and requirements associated with them described. Within Chapter Three, Factors for Separation and Integration in Architectural and Engineering Design, I examine selected design literature to detail several factors impacting upon the historic and contemporary relationship between architects and engineers, and to introduce the problem towards which this thesis is addressed. I describe a process of specialisation that has led architects and engineers to see different aspects of a common problem, detail the historical factors for separation, the current relationship between domains and the emerging idea of increased integration during the early design phase. The aim of this section is primarily contextual - to introduce the characters and to understand why their interaction can be difficult - and investigation occurs through the concepts of specialisation and disciplinary roles. Chapter Four, Unravelling Interdependency, establishes an understanding of interdependency through the concept of collaboration. While I differentiate interdependency from collaboration because of the inconsistent manner in which the latter term is employed, the concept of collaboration is useful to initialise my understanding of interdependency because it, as opposed to the closely linked processes of cooperation and coordination, is recognised as being characterised by interdependency, and in fact is a viewed as a response specific to wider conditions of interdependency. From the literature, I identify four sites of intersection crucial to an understanding of interdependency; these are differing perceptions, shared and creative problem solving, communication and trust. These themes, which correlate with my practice experience at Arup Melbourne, are developed to introduce the concepts and vocabulary underlying my research. Chapter Five, Intersections & Interdependency between Architects and Engineers, grounds these four sites of intersection within contemporary issues of digital architectural and engineering practice. Each site is developed firstly through reference to design literature and secondly through the experiences and understandings of senior Arup practitioners as captured through my interviews. The views and experiences of these practitioners are used to locate digital limits to, and potential solutions for, interdependent design exploration between architects and engineers as they are experienced within and by practice. Through this combination of design literature and grounded experience, I extend: * the understanding of differing perceptions through reference to problems associated with digital information transfer. * the understanding of joint and creative problem solving by connecting it to the notion of performance-based design. * the understanding of communication by focussing it upon the idea of back propagating design information. * the understanding of trust by connecting it to the management and reduction of perceived complexity and risk. Chapter Six, Testing through Projects, details the project studies undertaken within this research. These studies are grouped into three discourses, characterized as Design(Arch)Design(Eng), Design|Analysis and Design|Making. As suggested by the concurrency operator that separates the two terms that constitute each of the three labels, each discourse tests how architectural and engineering explorations might execute in parallel. The section Design(Arch)|Design(Eng) reports projects that use a common language of geometry to link architectural and engineering design ideas through geometric interpretation. The section Design|Analysis reports projects in which analytical tools have been used generatively to actively guide and synthesise design exploration. The final section, Design|Making, reports projects in which the architectural and engineering design processes are synthesised around the procurement of fabrication information. Conclusions are then drawn and discussed in Chapter Seven. In evaluating the research I discuss how 3D digital design tools have enabled alternative approaches that resolve issues associated with differing perceptions, establishing common meanings, communication and trust. I summarise how these approaches have enabled increased interdependency in architect engineer interaction. Lastly, I draw together the impacts of intersecting 3D digital aspects of architectural and engineering design exploration during the early design phase, and indicate those aspects that require further analysis and research.
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Goodale, Benjamin. "Crossfit design maximizing building potential across broad time and modal domains /." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/theses/304/.
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Walker, James D. "Design of vehicle routing problem domains for a hyper-heuristic framework." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/30596/.
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The branch of algorithms that uses adaptive methods to select or tune heuristics, known as hyper-heuristics, is one that has seen a large amount of interest and development in recent years. With an aim to develop techniques that can deliver results on multiple problem domains and multiple instances, this work is getting ever closer to mirroring the complex situations that arise in the corporate world. However, the capability of a hyper-heuristic is closely tied to the representation of the problem it is trying to solve and the tools that are available to do so. This thesis considers the design of such problem domains for hyper-heuristics. In particular, this work proposes that through the provision of high-quality data and tools to a hyper-heuristic, improved results can be achieved. A definition is given which describes the components of a problem domain for hyper-heuristics. Building on this definition, a domain for the Vehicle Routing Problem with Time Windows is presented. Through this domain, examples are given of how a hyper- heuristic can be provided extra information with which to make intelligent search decisions. One of these pieces of information is a measure of distance between solution which, when used to aid selection of mutation heuristics, is shown to improve results of an Iterative Local Search hyper-heuristic. A further example of the advantages of providing extra information is given in the form of the provision of a set of tools for the Vehicle Routing Problem domain to promote and measure ’fairness’ between routes. By offering these extra features at a domain level, it is shown how a hyper-heuristic can drive toward a fairer solution while maintaining a high level of performance.
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Alshaikh, Mohammed Saleh Abdullah. "Design of variation-tolerant synchronizers for multiple clock and voltage domains." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2482.
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Parametric variability increasingly affects the performance of electronic circuits as the fabrication technology has reached the level of 32nm and beyond. These parameters may include transistor Process parameters (such as threshold voltage), supply Voltage and Temperature (PVT), all of which could have a significant impact on the speed and power consumption of the circuit, particularly if the variations exceed the design margins. As systems are designed with more asynchronous protocols, there is a need for highly robust synchronizers and arbiters. These components are often used as interfaces between communication links of different timing domains as well as sampling devices for asynchronous inputs coming from external components. These applications have created a need for new robust designs of synchronizers and arbiters that can tolerate process, voltage and temperature variations. The aim of this study was to investigate how synchronizers and arbiters should be designed to tolerate parametric variations. All investigations focused mainly on circuit-level and transistor level designs and were modeled and simulated in the UMC90nm CMOS technology process. Analog simulations were used to measure timing parameters and power consumption along with a “Monte Carlo” statistical analysis to account for process variations. Two main components of synchronizers and arbiters were primarily investigated: flip-flop and mutual-exclusion element (MUTEX). Both components can violate the input timing conditions, setup and hold window times, which could cause metastability inside their bistable elements and possibly end in failures. The mean-time between failures is an important reliability feature of any synchronizer delay through the synchronizer. The MUTEX study focused on the classical circuit, in addition to a number of tolerance, based on increasing internal gain by adding current sources, reducing the capacitive loading, boosting the transconductance of the latch, compensating the existing Miller capacitance, and adding asymmetry to maneuver the metastable point. The results showed that some circuits had little or almost no improvements, while five techniques showed significant improvements by reducing τ and maintaining high tolerance. Three design approaches are proposed to provide variation-tolerant synchronizers. wagging synchronizer proposed to First, the is significantly increase reliability over that of the conventional two flip-flop synchronizer. The robustness of the wagging technique can be enhanced by using robust τ latches or adding one more cycle of synchronization. The second approach is the Metastability Auto-Detection and Correction (MADAC) latch which relies on swiftly detecting a metastable event and correcting it by enforcing the previously stored logic value. This technique significantly reduces the resolution time down from uncertain synchronization technique is proposed to transfer signals between Multiple- Voltage Multiple-Clock Domains (MVD/MCD) that do not require conventional level-shifters between the domains or multiple power supplies within each domain. This interface circuit uses a synchronous set and feedback reset protocol which provides level-shifting and synchronization of all signals between the domains, from a wide range of voltage-supplies and clock frequencies. Overall, synchronizer circuits can tolerate variations to a greater extent by employing the wagging technique or using a MADAC latch, while MUTEX tolerance can suffice with small circuit modifications. Communication between MVD/MCD can be achieved by an asynchronous handshake without a need for adding level-shifters.
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Azzam, Said Rabah. "Developing a compositional ontology alignment framework for unifying business and engineering domains." Thesis, University of Portsmouth, 2012. https://researchportal.port.ac.uk/portal/en/theses/developing-a-compositional-ontology-alignment-framework-for-unifying-business-and-engineering-domains(858b71bb-7570-4c07-a3e6-9d1b3992c9f6).html.
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In the context of the Semantic Web, ontologies refer to the consensual and formal description of shared concepts in a domain. Ontologies are said to be a way to aid communication between humans and machines and also between machines for agent communication. The importance of ontologies for providing a shared understanding of common domains, and as a means for data exchange at the syntactic and semantic level has increased considerably in the last years. Therefore, ontology management becomes a significant task to make distributed and heterogeneous knowledge bases available to the end users. Ontology alignment is the process where ontology from different domains can be matched and processed further together, hence sharing a common understanding of the structure of information among different people. This research starts from a comprehensive review of the current development of ontology, the concepts of ontology alignments and relevant approaches. The first motivation of this work is trying to summarise the common features of ontology alignment and identify underdevelopment areas of ontology alignment. It then works on how complex businesses can be designed and managed by semantic modelling which can help define the data and the relationships between these entities, which provides the ability to abstract different kinds of data and provides an understanding of how the data elements relate. The main contributions of this work is to develop a framework of handling an important category of ontology alignment based on the logical composition of classes, especially under a case that one class from a certain domain becomes a logic prerequisites (assumption) of another class from a different domain (commitment) which only happens if the class from the first domain becomes valid. Under this logic, previously un-alignable classes or miss-aligned classes can be aligned in a significantly improved manner. A well-known rely/guarantee method has been adopted to clearly express such relationships between newly-alignable classes. The proposed methodology has be implemented and evaluated on a realistic case study.
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Sander, Jeffry D. "Characterization and design of C2H2 zinc finger proteins as custom DNA binding domains." [Ames, Iowa : Iowa State University], 2008.
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Satish, Sneha. "A Mechanism Design Approach for Mining 3-clusters across Datasets from Multiple Domains." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1471345904.
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Strauss, Alisa N. Ph D. "Design by Consensus: Designing Effective Icons Using Quantitative Ethnography." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467126649.
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Green, Tuwanda Lee. "Healthy by Design: Development of a Biophilia Design Decision Support Framework." Diss., Virginia Tech, 2021. http://hdl.handle.net/10919/103279.
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Scholars widely accept that the well-documented benefits of biophilia–the human being's strong urge to connect with nature–are genuine to improved health. Then why, with the global acceptance and scientific validity of wellness design concepts, do architects not use this beneficial concept regularly–especially when designing isolated workspaces? This qualitative research explores architecture's current design decision process to better understand this design phenomenon, and to identify where architectural biophilic knowledge domains may be deficient. This study explores questions such as: Does the architect's lack of biophilic knowledge and/or structured wellness design decision support framework affect the decision? Would the existence of a wellness design tool better support the design decision? An explanatory case study using a purposeful study sample of architects, biophilia design experts, and associated specialists is used to develop design decision support frameworks. Level 1 establishes a propositional theory derived from the literature and professional experience, level 2 from architect interviews and observational meetings, and level 3 from a Delphi workgroup session. Framework evolutions help identify design-phase-specific knowledge gaps. This study finds that a deficiency in early exposure to a priori, explicit and tacit biophilic knowledge is creating a critical gap, thus diminishing a posteriori biophilic knowledge and research in the architecture profession. This study asserts that early exposure to biophilic theories and principles can enhance the profession and provide a knowledge bridge using an informed biophilia design support framework with a proposed biophilia project management tool.Doctor of Philosophy
Few will dispute that the well-documented benefits of biophilia–the human being's strong urge to connect with nature–are genuine to improved health. Then why, with the global acceptance and scientific validity of wellness design concepts, do architects not use this beneficial concept regularly–especially when designing windowless workspaces? A qualitative explanatory case study using a purposeful study sample of architects, biophilia design experts, and associated specialists was used to develop a design decision support framework that evolved from level 1-3. Framework progressions helped identify specific knowledge gaps in each design phase. This study found that a deficiency in early exposure to a priori, explicit and tacit biophilic knowledge is creating a critical gap, thus diminishing a posteriori biophilic knowledge and research in the architecture profession. This study asserts that early exposure to biophilic theories and principles can enhance the profession and provide a knowledge bridge using an informed biophilia design decision support framework with a proposed biophilia project management tool.
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Kanje, Sara. "Engineering of small IgG binding domains for antibody labelling and purification." Doctoral thesis, KTH, Proteinteknologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-191303.
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In protein engineering, rational design and selection from combinatorial libraries are methods used to develop proteins with new or improved features. A very important protein for the biological sciences is the antibody that is used as a detecting agent in numerous laboratory assays. Antibodies used for these purposes are often ”man-made”, by immunising animals with the desired target, or by selections from combinatorial libraries. Naturally, antibodies are part of the immune defence protecting us from foreign attacks from e.g. bacteria or viruses. Some bacteria have evolved surface proteins that can bind to proteins abundant in the blood, like antibodies and serum albumin. By doing so, the bacteria can cover themselves in the host’s own proteins and through that evade being detected by the immune system. Two such proteins are Protein A from Staphylococcus aureus and Protein G from group C and G Streptococci. Both these proteins contain domains that bind to antibodies, one of which is denoted C2 (from Protein G) and another B (from Protein A). The B domain have been further engineered to the Z domain. In this thesis protein engineering has been used to develop variants of the C2 and Z domains for site-specific labelling of antibodies and for antibody purification with mild elution. By taking advantage of the domains’ inherent affinity for antibodies, engineering and design of certain amino acids or protein motifs of the domains have resulted in proteins with new properties. A photo crosslinking amino acid, p-benzoylphenylalanine, have been introduced at different positions to the C2 domain, rendering three new protein domains that can be used for site-specific labelling of antibodies at the Fc or Fab fragment. These domains were used for labelling antibodies with lanthanides and used for detection in a multiplex immunoassay. Moreover, a library of calcium-binding loops was grafted onto the Z domain and used for selection of a domain that binds antibodies in a calcium dependent manner. This engineered protein domain can be used for the purification of antibodies using milder elution conditions, by calcium removal, as compared to traditional antibody purification.
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Bjerkefeldt, Emma. "Cofactor synthesis for bio-inspired de novo design of solar-energy harvesting protein domains." Thesis, KTH, Skolan för bioteknologi (BIO), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-176009.
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The world's population is rapidly increasing and so is the demand for energy. Problems with increased CO2 production and global warming makes the need for clean and cheap energy one of the most important challenges facing the future human society. Solar energy is the most abundant energy source accessible to humankind and this energy could be captured and stored as chemical bonds with a device mimicking the process of light driven photosynthesis in plants. This work explains how an artificial protein could perform charge separation and first trials for synthesis of two different co factors, Azido Viologen and Tetra methyl azido viologen has been carried out. It also suggests a way of attaching the co factors to the protein by incorporating the unnatural amino acid Homopropargylglycine in the protein an use Huisgen cycloaddition for the attachment. Azido Viologen seems to have been successfully synthesized but needs to be further characterized by mass spectrometry and NMR bu the Tetra Methyl Azido Viologen was not. The Homopropargylglycine was not successfully incorporated in the protein but the likely reason for this seems to be the usage of the wrong expression system.
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Gootee, Roje Stanis. "Merging public and private domains implications for the design and implementation of natural resource policy /." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Dissertations/Spring2009/r_gootee_031109.pdf.
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Kontitsis, Michail. "Design and implementation of an integrated dynamic vision system for autonomous systems operating in uncertain domains." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0002852.
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Chi, Celestine. "Post-synaptic Density Disc Large Zo-1 (PDZ) Domains : From Folding and Binding to Drug Targeting." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126129.
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Understanding how proteins fold and bind is interesting since these processes are central to most biological activity. Protein folding and protein-protein interaction are by themselves very complex but using a good and robust system to study them could ease some of the hurdles. In this thesis I have tried to answer some of the fundamental questions of protein folding and binding. I chose to work with PDZ domains, which are protein domains consisting of 90-100 amino acids. They are found in more than 400 human proteins and function mostly as protein-protein interaction units. These proteins are very stable, easy to express and purify and their folding reaction is reversible under most laboratory conditions. I have characterized the interaction of PSD-95 PDZ3 domain with its putative ligand under different experimental conditions and found out that its binding kinetics is sensitive to salt and pH. I also demonstrated that the two conserved residues R318 and H372 in PDZ3 are responsible for the salt and pH effect, respectively, on the binding reaction. Moreover, I determined that for PSD 95 PDZ3 coupling of distal residues to peptide binding was better described by a distance relationship and there was a very weak evidence of an allosteric network. Further, I showed that another PDZ domain, SAP97 PDZ2 undergoes conformational change upon ligand binding. Also, I characterized the binding mechanism of a dimeirc ligand/PDZ1-2 tandem interaction and showed that despite its apparent complexity the binding reaction is best described by a square scheme. Additionally, I determined that for the SAP 97 PDZ/HPV E6 interaction that all three PDZ domains each bind one molecule of the E6 protein and that a set of residues in the PDZ2 of SAP 97 could operate in an unexpected long-range manner during E6 interaction. Finally, I showed that perhaps all members in the PDZ family could fold via a three state folding mechanism. I characterized the folding mechanism of five different PDZ domains having similar overall fold but different primary structure and the results indicate that all five fold via an intermediate with two transition states. Transition state one is rate limiting at low denaturant concentration and vice versa for transition state two. Comparing and characterizing the structures of the transition states of two PDZ domains using phi value analysis indicated that their early transition states are less similar as compared to their late transition states.
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Kohler, Francis M. "Divergence of Millennial Digital Learning: A Study of Generational Domains Involving Differential Instruction Using Pedagogy and Tools." Bowling Green State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1333566362.
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Lawrence, Andrew James. "Development of a Hybrid Atomic Force and Scanning Magneto-Optic Kerr Effect Microscope for Investigation of Magnetic Domains." PDXScholar, 2011. https://pdxscholar.library.pdx.edu/open_access_etds/147.
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We present the development of a far-field magneto-optical Kerr effect microscope. An inverted optical microscope was constructed to accommodate Kerr imaging and atomic force microscopy. In Kerr microscopy, magnetic structure is investigated by measuring the polarization rotation of light reflected from a sample in the presence of a magnetic field. Atomic force microscopy makes use of a probe which is scanned over a sample surface to map the topography. The design was created virtually in SolidWorks, a three-dimensional computer-aided drafting environment, to ensure compatibility and function of the various components, both commercial and custom-machined, required for the operation of this instrument. The various aspects of the microscope are controlled by custom circuitry and a field programmable gate array data acquisition card at the direction of the control code written in National Instrument LabVIEW. The microscope has proven effective for both Kerr and atomic force microscopy. Kerr images are presented which reveal the bit structure of magneto-optical disks, as are atomic force micrographs of an AFM calibration grid. Also discussed is the future direction of this project, which entails improving the resolution of the instrument beyond the diffraction limit through near-field optical techniques. Preliminary work on fiber probe designs is presented along with probe fabrication work and the system modifications necessary to utilize such probes.
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Daschiel, Gertraud Maria [Verfasser]. "Strategies to reduce friction losses and their implications for the energy efficient design of internal flow domains / Gertraud Maria Daschiel." Karlsruhe : KIT Scientific Publishing, 2015. http://www.ksp.kit.edu.
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Wellhausen, Jeffrey Daniel. "Design of functional RNAs through combinatorial selections and characterization of a fluorescent cytosine analogue in DNA /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8507.
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Helps, C. Richard G. "Evolving Information Technology: A Case Study of the Effects of Constant Change on Information Technology Instructional Design Architecture." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2388.
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A major challenge for Information Technology (IT) programs is that the rapid pace of evolution of computing technology leads to frequent redesign of IT courses. The problem is exacerbated by several factors. Firstly, the changing technology is the subject matter of the discipline and is also frequently used to support instruction; secondly, this discipline has only been formalized as a four-year university program within recent years and there is a lack of established textbooks and curriculum models; finally, updating courses is seldom rewarded in a higher education system that favors research and teaching for promotion and tenure. Thus, continuously updating their courses place a significant burden on the faculty. A case study approach was used to describe and explain the change processes in updating IT courses. Several faculty members at two institutions were interviewed and course changes were identified and analyzed. The analysis revealed a set of recurrent themes in change processes. An instructional design architecture approach also revealed a set of design domains representing the structure of the change processes. The design domains were analyzed in terms of the design decisions they represented, and also in terms of structures, functions and activities, which are related to Structures-Behaviors-Functions (SBF) analysis. The design domains model helped to explain both negative and positive outcomes that were observed in the data. When design efforts impact multiple domains the design is likely to be more difficult. Understanding the design domain architecture will assist future designers in this discipline.
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Daschiel, Gertraud Maria [Verfasser], and B. [Akademischer Betreuer] Frohnapfel. "Strategies to reduce friction losses and their implications for the energy efficient design of internal flow domains / Gertraud Maria Daschiel. Betreuer: B. Frohnapfel." Karlsruhe : KIT-Bibliothek, 2014. http://d-nb.info/1061069230/34.
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Celentano, U. (Ulrico). "Dependable cognitive wireless networking:modelling and design." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526204192.
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Abstract Radio communication is used in increasingly diversified device typologies. Telecommunications with a reduced detrimental impact on health and environment, and an improved cost-efficiency and working lifetime are expected by institutions, end-users, operators and manufacturers. Moreover, with more networks present or more articulated systems, dependability of the entirety is to be ensured. The related need of efficiency in various compartments – such as in the use energy or the radio spectrum – and of effectiveness in adapting to changing operating conditions can be achieved with cognitive features. This dissertation addresses network reconfiguration and dependability by cognitive measures from multiple perspectives – each covered by a respective part of this work – providing guidelines for cognitive networks design. A rationalising view on cognitive networks with related taxonomies and models includes a discussion on the dynamics and interactions in networks operating closely and simultaneously (here, concurrent networks). While cognitive domains are specified for cognitive functions, with a more generic scope control functions are assigned to topological domains. This allows a flexible exploitation of the system design by decoupling the specification of system functions from their mapping onto network devices that will host them. As interaction plays an important role in many topical scenarios, a model for networked engineered cognitive entities comprising four categories (observation, interworking, consolidation, operation) and two levels (a cognitive frontier and a metacognitive hub) is presented here. Its cognitive phases are considered with regard to the other architectural elements. Moving the focus down to the levers for exploitation of context awareness, are presented solutions for efficient use of resources and dependability in general, considering the network dynamics. For communication link and network adaptation, the effective capacity is captured by a compact-form expression also considering imperfections, while learning is exploited for reducing overhead, and collaboration for fairly maximising energy saveTiivistelmä Käyttäjät, operaattorit ja laitevalmistajat toivovat tulevilta tietoliikennejärjestelmiltä sekä aiempaa pienempiä haitallisia vaikutuksia terveyteen ja ympäristöön että parannettua kustannustehokkuutta ja toiminta-aikaa. Lisäksi olisi varmistettava useiden verkkojen ja niiden muodostamien monimutkaisten järjestelmien kokonaisuuden luotettava toiminta. Tarvittava tehokkuus energian ja radioresurssien käytössä, samoin kuin kyky sopeutua muuttuviin käyttötilanteisiin, voidaan saavuttaa kognitiivisilla radioteknikoilla. Tämä väitöskirja käsittelee kognitiivisten menetelmien tuomaa radioverkkojen mukauttamista ja luotettavuutta eri näkökulmista. Samalla esitetään kognitiivisten verkkojen suunnittelun periaatteita ja lähtökohtia. Väitöskirja sisältää katsauksen kognitiivisiin radioverkkoihin niihin liittyvine luokitteluineen ja malleineen, sekä tarkastelee samanaikaisesti ja läheisesti toimivien verkkojen (rinnakkaisten verkkojen) dynamiikkaa ja vuorovaikutuksia. Työssä määritetään kognitiiviset lohkot kognitiivisine toimintoineen, kun taas topologiset tasot hallintatoimintoineen määritetään yleisemmin. Tämä mahdollistaa järjestelmäsuunnittelun joustavan hyödyntämisen erottamalla järjestelmän toimintojen määrittelyn toteuttavista verkkolaitteista. Koska vuorovaikutus on merkittävä tekijä useissa sovellusskenaarioissa, verkottuneille keinotekoisille kognitiivisille yksiköille ehdotetaan tässä neljä luokkaa (havainnointi, yhteistoiminta, vakauttaminen, toiminta) sekä kaksi vyöhykettä (kognitiivinen raja-alue ja metakognitiivinen keskus) sisältävää mallia. Mallin kognitiiviset vaiheet käsitellään suhteessa muihin arkkitehtuurin elementteihin. Järjestelmän kontekstitietoisuuden hyväksikäyttöön liittyen esitetään ratkaisuja resurssien tehokkaaseen käyttöön ja yleisemmin luotettavuuteen ottaen huomioon verkkojen dynamiikkaa. Yhteyksien ja verkkojen mukauttamisesta esitetään analyyttinen ratkaisu saavutettavan tehollisen kapasiteetin määrittämiseksi, huomioiden mahdolliset epäideaalisuudet. Kognitiivista oppimista hyödynnetään hallintalikenteen vähentämiseksi ja yhteistyötä energiansäästön maksimoimiseksi verkon alueella tasapuolisesti
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Emero, Michael F. "Using naturally occurring texts as a knowledge acquisition resource for knowledge base design : developing a knowledge base taxonomy on microprocessors /." Master's thesis, This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-02162010-020204/.
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Szejka, Anderson Luis. "Contribution to interoperable products design and manufacturing information : application to plastic injection products manufacturing." Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0159/document.
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La compétitivité toujours plus importante et la mondialisation ont mis l'industrie manufacturière au défi de rationaliser les différentes façons de mettre sur le marché de nouveaux produits dans un délai court, avec des prix compétitifs tout en assurant des niveaux de qualité élevés. Le PDP moderne exige simultanément la collaboration de plusieurs groupes de travail qui assurent la création et l’échange d’information avec des points de vue multiples dans et à travers les frontières institutionnelles. Dans ce contexte, des problèmes d’interopérabilité sémantique ont été identifiés en raison de l'hétérogénéité des informations liées à des points de vue différents et leurs relations pour le développement de produits. Le travail présenté dans ce mémoire propose un cadre conceptuel d’interopération pour la conception et la fabrication de produits. Ce cadre est basé sur un ensemble d’ontologies clés, de base d’ingénierie et sur des approches de cartographie sémantique. Le cadre soutient les mécanismes qui permettent la conciliation sémantique en termes de partage, conversion et traduction, tout en améliorant la capacité de partage des connaissances entre les domaines hétérogènes qui doivent interopérer. La recherche a particulièrement porté sur la conception et la fabrication de produits tournants en plastique et explore les points particuliers de la malléabilité - la conception et la fabrication de moules. Un système expérimental a été proposé à l’aide de l'outil Protégé pour modéliser des ontologies de base et d’une plateforme Java intégrée à Jena pour développer l'interface avec l'utilisateur. Le concept et la mise en œuvre de cette recherche ont été testés par des expériences en utilisant des produits tournants en plastiques. Les résultats ont montré que l'information et ses relations rigoureusement définies peuvent assurer l'efficacité de la conception et la fabrication du produit dans un processus de développement de produits moderne et collaboratifGlobal competitiveness has challenged manufacturing industry to rationalise different ways of bringing to the market new products in a short lead-time with competitive prices while ensuring higher quality levels. Modern PDP has required simultaneously collaborations of multiple groups, producing and exchanging information from multi-perspectives within and across institutional boundaries. However, it has been identified semantic interoperability issues in view of the information heterogeneity from multiple perspectives and their relationships across product development. This research proposes a conceptual framework of an Interoperable Product Design and Manufacturing based on a set of core ontological foundations and semantic mapping approaches. This framework has been particularly instantiated for the design and manufacturing of plastic injection moulded rotational products and has explored the particular viewpoints of moldability, mould design and manufacturing. The research approach explored particular information structures to support Design and Manufacture application. Subsequently, the relationships between these information structures have been investigated and the semantics reconciliation has been designed through mechanisms to convert, share and translate information from the multi-perspectives. An experimental system has been performed using the Protégé tool to model the core ontologies and the Java platform integrated with the Jena to develop the interface with the user. The conceptual framework proposed in this research has been tested through experiments using rotational plastic products. Therefore, this research has shown that information rigorously-defined and their well-defined relationships can ensure the effectiveness of product design and manufacturing in a modern and collaborative PDP
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De, Villiers Mary Ruth. "The dynamics of theory and practice in instructional systems design." Diss., Pretoria : [s.n.], 2002. http://upetd.up.ac.za/thesis/available/etd-02212003-180121.
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Erbas, Irem. "An Analysis Of Living Environments Of The Elderly And A Project For Assisted Living In Ankara." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607962/index.pdf.
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Ageing has become a significant research area in the last few decades. The most important reason that makes ageing issue significant is the increasing rate of the older indviduals within the population all around the world. Statistical data on ageing both in Turkey and in the world reveals that, in the near future, the number of population over 65 will increase dramatically. It can be asserted that there will be an urgent need of specifically designed accommodation for this portion of the population. Hence, this thesis intends to search for and
practice a design solution for the elderly housing.
One of the instruments that supported the formulation of such a solution is the subject of &lsquouniversal design&rsquo
. Within the scope of this study, the principles of universal design and its relationship with ageing are defined, examined and evaluated. It is accepted that living environment has effect on the enhancement of the individual&rsquo
s quality of life. For this reason, the relationship between person and environment is briefly discussed in congruence with principles of universal design and provision of quality of life. Accessibility, safety, privacy, autonomy and independence are the common concerns of universal design and provision of a higher quality of life. With review of the definitions of specific elderly housing types, another approach for this study is to make a case study of the existing architectural solutions for the elderly housing. This helped to understand architectural approaches to the relationship between ageing and environment in the world. In the light of the findings, an architectural project, presenting a habitable environment for the elderly, is proposed. For the project, the concept of &ldquo
assisted living&rdquo
as a new category for elderly housing, is chosen.
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Möller, Torsten. "Spatial domain filter design /." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488190109868038.
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Vallon, Gary. "Synthèse d'inhibiteurs de l'interaction entre la protéine à domaine PDZ, PSD-95 et le récepteur de la sérotoninte 5-HT2A pour le traitement des douleurs neuropathiques." Thesis, Clermont-Ferrand 2, 2016. http://www.theses.fr/2016CLF22664.
Full textAbstract:
Les protéines à domaines PDZ sont impliquées dans des interactions protéine-protéine (IPP) et participent aux transports de signaux impliqués dans de nombreuses pathologies (cancer, mucoviscidose, douleur,…). L’interruption de l’interaction entre la protéine à domaine PDZ, PSD-95, et le récepteur de la sérotonine, 5-HT2A, réduit l’hyperalgie mécanique sur un modèle expérimental de douleur neuropathique chez les rats. Afin de concevoir de nouveaux inhibiteurs de cette interaction, antalgiques potentiels, trois stratégies ont été développées au cours de ces travaux. Une première stratégie a consisté à réaliser une étude de relation structure-activité à partir d’un inhibiteur connu, qui nous a permis d’identifier des groupements pharmacophores et ainsi obtenir une nouvelle molécule possédant un noyau indolique, capable d’inhiber l’interaction entre PSD-95 et 5-HT2A et possédant un effet anti-hyperalgique chez le rat neuropathique. La deuxième stratégie a consisté à valider la méthode du fragment-based drug design aux protéines à domaines PDZ en réalisant la déconstruction d’un inhibiteur connu de l’interaction en plusieurs fragments qui ont été criblés par RMN HSQC 1H-15N. Une évaluation systématique par RMN de chaque couple de fragments, suivie d’une étude de modélisation moléculaire a ensuite permis de mettre en évidence trois nouvelles molécules qui ont été synthétisées et évaluées par RMN HSQC 1H-15N. La troisième stratégie a été une approche peptidomimétique à partir de l’extrémité C-terminale de 5-HT2A, qui a conduit à la synthèse d’un peptoïde capable d’interagir avec la protéine à domaine PDZ. Ces études nous permettent d’envisager le développement de nouveaux antalgiques soit issus de la synthèse organique soit issus de mimes de peptidesPDZ domains proteins are involved in protein-protein interaction (PPI) and participate in the transport of signals involved in numerous diseases (cancer, cystic fibrosis, pain, …). The disruption the interaction between the PDZ domains protein, PSD-95, and the serotonin receptor, 5-HT2A, reduces mechanical hyperalgesia in a rodent model of neuropathic pain in rats. To design new inhibitors as potential analgesics of this interaction, three strategies have been developed in this work. A first strategy was to conduct a study of structure-activity relationship from a known inhibitor, which allowed us to identify the pharmacophore groups and obtain a new molecule with an indole ring, capable of inhibiting the interaction between PSD-95 and 5-HT2A and possessing an anti-hyperalgesic effect on neuropathic rats. The second strategy was to validate the method of fragment-based drug design with PDZ domains proteins by deconstruction of a known inhibitor of the interaction in several fragments which were screened by NMR HSQC 1H-15N. Systematic evaluation by NMR of each pair of fragments, followed by molecular modeling study was then used to highlight three new molecules that were synthesized, and evaluated by NMR HSQC 1H-15N. The third strategy was a peptidomimetic approach from the C-terminal of 5-HT2A receptors, which led to the synthesis of a peptoid able to interact with the PDZ domain protein. These studies allow us to consider the development of new analgesics either from organic synthesis or from peptide mimetics
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Tell, Eric. "A Domain Specific DSP Processor." Thesis, Linköping University, Department of Electrical Engineering, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-980.
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This thesis describes the design of a domain specific DSP processor. The thesis is divided into two parts. The first part gives some theoretical background, describes the different steps of the design process (both for DSP processors in general and for this project) and motivates the design decisions made for this processor.
The second part is a nearly complete design specification.
The intended use of the processor is as a platform for hardware acceleration units. Support for this has however not yet been implemented.
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Liu, Feng. "Spatial pattern and uncertainty of soil carbon and nitrogen in a subtropical savanna landscape in southern Texas." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1609.
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Marquez, Carlos Ivan Castro. "Análise da influência do uso de domínios de parâmetros sobre a eficiência da verificação funcional baseada em estimulação aleatória." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/3/3140/tde-26032009-172605/.
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Uma das maiores restrições que existe atualmente no fluxo de projeto de CIs é a necessidade de um ciclo menor de desenvolvimento. Devido às grandes dimensões dos sistemas atuais, é muito provável encontrar no projeto de blocos IP, erros ou bugs originados na passagem de uma dada especificação inicial para seus correspondentes modelos de descrição de hardware. Isto faz com que seja necessário verificar tais modelos para garantir aplicações cem por cento funcionais. Uma das técnicas de verificação que tem adquirido bastante popularidade recentemente é a verificação funcional, uma vez que é uma alternativa que ajuda a manter baixos custos de validação dos modelos HDL ao longo do projeto completo do circuito. Na verificação funcional, que está baseada em ambientes de simulação, a funcionalidade completa (ou relevante) do modelo é explorada, aplicando-se casos de teste, um após o outro. Isto permite examinar o modelo em todas as seqüências e combinações de entradas desejadas. Na verificação funcional, existe a possibilidade de simular o modelo estimulando-o com casos de teste aleatórios, o qual ajuda a cobrir um amplo número de estados. Para facilitar a aplicação de estímulos em simulação de circuitos, é comum que espaços definidos por parâmetros de entrada sejam limitados em sua abrangência e agrupados de tal forma que subespaços sejam formados. No desenvolvimento de testbenches, os geradores de estímulos aleatórios podem ser criados de forma a conter subespaços que se sobrepõem (resultando em estímulos redundantes) ou subespaços que contenham condições que não sejam de interesse (resultando em estímulos inválidos). É possível eliminar ou diminuir, os casos de teste redundantes e inválidos através da aplicação de metodologias de modificação do espaço de estímulos de entrada, e assim, diminuir o tempo requerido para completar a simulação de modelos HDL. No presente trabalho, é realizada uma análise da aplicação da técnica de organização do espaço de entrada através de domínios de parâmetros do IP, e uma metodologia é desenvolvida para tal, incluindo-se, aí, uma ferramenta de codificação automática de geradores de estímulos aleatórios em linguagem SyatemC: o GET_PRG. Resultados com a aplicação da metodologia é comparada a casos de aplicação de estímulos aleatórios gerados a partir de um espaço de estímulos de entrada sem modificações.Como esperado, o número de casos de teste redundantes e inválidos aplicados aos testbenches foi sempre maior para o caso de estimulação aleatória a partir do espaço de estímulos de entrada completo com um tempo de execução mais longo.One of the strongest restrictions that exist throughout ICs design flow is the need for shorter development cycles. This, along with the constant demand for more functionalities, has been the main cause for the appearance of the so-called System-on-Chip (SOC) architectures, consisting of systems that contain dozens of reusable hardware blocks (Intellectual Properties, or IPs). The increasing complexity makes it necessary to thoroughly verify such models in order to guarantee 100% functional applications. Among the current verification techniques, functional verification has received important attention, since it represents an alternative that keeps HDL validation costs low throughout the circuits design cycle. Functional verification is based in testbenches, and it works by exploring the whole (or relevant) models functionality, applying test cases in a sequential fashion. This allows the testing of the model in all desired input sequences and combinations. There are different techniques concerning testbench design, being the random stimulation an important approach, by which a huge number of test cases can be automatically created. In order to ease the stimuli application in circuit simulation, it is common to limit the range of the space defined by input parameters and to group such restricted parameters in sub-spaces. In testbench development, it may occur the creation of random stimuli generators containing overlapping sub-spaces (resulting in redundant stimuli) or sub-spaces containing conditions of no interest (resulting in invalid stimuli). It is possible to eliminate, or at least reduce redundant and invalid test cases by modifying the input stimuli space, thus, diminishing the time required to complete the HDL models simulation. In this work, the application of a technique aimed to organize the input stimuli space, by means of IP parameter domains, is analyzed. A verification methodology based on that is developed, including a tool for automatic coding of random stimuli generators using SystemC: GET_PRG. Results on applying such a methodology are compared to cases where test vectors from the complete verification space are generated. As expected, the number of redundant test cases applied to the testbenches was always greater for the case of random stimulation on the whole (unreduced, unorganized) input stimuli space, with a larger testbench execution time.
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Azimifar, Seyedeh-Zohreh. "Image Models for Wavelet Domain Statistics." Thesis, University of Waterloo, 2005. http://hdl.handle.net/10012/938.
Full textAbstract:
Statistical models for the joint statistics of image pixels are of central importance in many image processing applications. However the high dimensionality stemming from large problem size and the long-range spatial interactions make statistical image modeling particularly challenging. Commonly this modeling is simplified by a change of basis, mostly using a wavelet transform. Indeed, the wavelet transform has widely been used as an approximate whitener of statistical time series. It has, however, long been recognized that the wavelet coefficients are neither Gaussian, in terms of the marginal statistics, nor white, in terms of the joint statistics.
The question of wavelet joint models is complicated and admits for possibilities, with statistical structures within subbands, across orientations, and scales. Although a variety of joint models have been proposed and tested, few models appear to be directly based on empirical studies of wavelet coefficient cross-statistics. Rather, they are based on intuitive or heuristic notions of wavelet neighborhood structures. Without an examination of the underlying statistics, such heuristic approaches necessarily leave unanswered questions of neighborhood sufficiency and necessity.
This thesis presents an empirical study of joint wavelet statistics for textures and other imagery including dependencies across scale, space, and orientation. There is a growing realization that modeling wavelet coefficients as independent, or at best correlated only across scales, may be a poor assumption. While recent developments in wavelet-domain Hidden Markov Models (notably HMT-3S) account for within-scale dependencies, we find that wavelet spatial statistics are strongly orientation dependent, structures which are surprisingly not considered by state-of-the-art wavelet modeling techniques.
To demonstrate the effectiveness of the studied wavelet correlation models a novel non-linear correlated empirical Bayesian shrinkage algorithm based on the wavelet joint statistics is proposed. In comparison with popular nonlinear shrinkage algorithms, it improves the denoising results.
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Dietz, Timothy Paul. "Conceptual design of multi-domain systems: products and materials." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33867.
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A key challenge facing designers creating innovative products is concept generation. Conceptual design is more effective when the design space is broadened by using an integrated design of product and material concepts approach. Conceptual design can also be accelerated by including problem solving and solution triggering tools in its structure. In this approach, structured analogy is used to transfer underlying principles from a solution suitable in one domain (i.e., product or mechanical domain) to an analogous solution in another domain (i.e., material domain). The nature of design analogy does not require as full of an exploration of the target domain as would otherwise be necessary; affording the possibility of a more rapid development. The addition of problem solving and solution triggering tools to a design method also decreases the design time and/or improves the quality of the final solution.
This approach is formulated through a combination of the Theory of Inventive Problem Solving (TRIZ) proposed by Altshuller, and the systematic approach of Pahl and Beitz, for products that are jointly considered at the product and material level. These types of problems are ones where customer performance requirements are fulfilled through both the designed product and the designed material. The systematic approach of Pahl and Beitz is used as the base method through which TRIZ is used as a means of transferring abstract information about the design problem between the domains with the aim of accelerating conceptual design. This also allows for multi-domain design tools such as Su-Field-Model integration with design repositories for the transfer of information at different levels of abstraction; expanding the design space and effectively directing the designer. The explanation of this approach is presented through a simple example of a spring design improvement and validated through concept generation of a reactive material containment system.
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Sadtchikova, Lena V. "Optimal shape design with domain decomposition." Thesis, This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-02132009-171349/.
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Wang, Yong. "Frequency domain coupled circuit-electromagnetic simulation /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/6071.
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Sheehy, Damian James. "Medial surface computation using a domain Delaunay triangulation." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239226.
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Suhaib, Syed Mohammed. "Formal Methods for Intellectual Property Composition Across Synchronization Domains." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/28952.
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A significant part of the System-on-a-Chip (SoC) design problem is in the correct composition of intellectual property (IP) blocks. Ever increasing clock frequencies make it impossible for signals to reach from one end of the chip to the other end within a clock cycle; this invalidates the so-called synchrony assumption, where the timing of computation and communication are assumed to be negligible, and happen within a clock cycle. Missing the timing deadline causes this violation, and may have ramifications on the overall system reliability. Although latency insensitive protocols (LIPs) have been proposed as a solution to the problem of signal propagation over long interconnects, they have their own limitations. A more generic solution comes in the form of globally asynchronous locally synchronous (GALS) designs. However, composing synchronous IP blocks either over long multicycle delay interconnects or over asynchronous communication links for a GALS design is a challenging task, especially for ensuring the functional correctness of the overall design. In this thesis, we analyze various solutions for solving the synchronization problems related with IP composition. We present alternative LIPs, and provide a validation framework for ensuring their correctness. Our
notion of correctness is that of latency equivalence between a latency insensitive design and its synchronous counterpart. We propose a trace-based framework for analyzing synchronous behaviors of different IPs, and provide a correct-by-construction protocol for their transformation to a GALS design. We also present a design framework for facilitating GALS designs. In the framework, Kahn process network specifications are refined into correct-by-construction GALS designs. We present formal definitions for the refinements towards different GALS architectures. For facilitating GALS in distributed embedded software, we analyze certain subclasses of synchronous designs using a Pomset-based semantic model that allows for desynchronization toward GALS.Ph. D.
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Li, F. "The design of control systems in the time domain." Thesis, University of Bradford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376716.
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Sun, Young Joo. "Engineering PDZ domain specificity." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6865.
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PSD-95/Dlg/ZO-1 (PDZ) domain - PDZ binding motif (PBM) interactions have been one of the most well studied protein-protein interaction systems through biochemical, biophysical and high-throughput screening (HTS) strategies. This has allowed us to understand the mechanism of individual PDZ-PBM interactions and the re-engineering of PBMs to bind tighter or to gain or lose certain specificity. However, there are several thousand native PDZ domains whose biological ligands remain unknown. Because of the low sequence identity among PDZ domain homologues, promiscuous binding profiles (defined as a PDZ domain that can accommodate a set of PBMs or a PBM that can be recognized by many PDZ domains), and context-dependent interaction mechanism, we have an inadequate understanding of the general molecular mechanisms that determine the PDZ-PBM specificity. Therefore, predicting PDZ specificity has been elusive. In addition, no de novo PBM ligand or artificial non-native PDZ domain have been successfully designed. This reflects the general challenges in understanding the general principles of PDZ-ligand interactions, namely that they are context-dependent, exhibit weak binding affinity, narrow binding energy range, and larger interaction surface than other protein-ligand interactions. Together, PDZ domains make good model systems to investigate the fundamental principles of protein-protein interactions with a wide spectrum of biomedical implications.
My studies suggest that understanding PBM specificity with the set of structural positions forming the binding pocket can connect sequence, structure and function of a PDZ domain in a general context. They also suggest that this way of understanding the specificity will shed light on prediction and engineering of specificity rationally. Structural analysis on most of the available PDZ domain structures was established to support the principle (Chapter I). The principle was tested against two different types of PBM; C-terminal PBM (Chapter II) and internal PBM (Chapter III), and shown to support better understanding and design of PDZ domain specificity. We further applied the principle to design de novo PDZ domains, and the preliminary data hints that it is optimistic to engineer PDZ domain specificity (Appendix A and B).
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Nicol, Robert A. (Robert Arthur) 1969. "A multi-domain process design and improvement framework." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62762.
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Thesis (Ph. D.)--Massachusetts Institute of Technology, Engineering Systems Division, 2010.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 379-385).
Processes in manufacturing, services, and healthcare are complex socio-technical systems composed of intricately sequenced activities supported by elements drawn from multiple domains. While many of these processes offer high performance, their complexity can make their design, improvement, troubleshooting, and change difficult due to the many possible and unforeseen interactions between elements. This thesis develops a design methodology and multi-domain network model for complex process design, change management, process improvement, and troubleshooting. As part of the methodology a feasibility analysis method based on solving the minimum cost flow problem for a network of process alternatives is presented to identify feasible processes subject to stakeholder requirements and constraints including performance, flexibility, modularity, and other system properties. A model based on Multi-Domain Matrix (MDM) concepts is developed specifically for process analysis called the Multi-Domain Process Matrix model (MDPM) to enumerate and analyze the interactions between process elements such that process performance under change and troubleshooting scenarios can be improved. The graph theory basis of the MDPM model enables its analysis using a proposed set of metrics derived from communications, social, and process network literature. As a demonstration of the use of the methodology, a complex DNA sequencing based surveillance process for Methicillin resistant Staphylococcus aureus (MRSA) in the US healthcare system is designed and a prototype implemented. Rapid advances in DNA-based technologies have greatly expanded the range of processes available to the clinical microbiology laboratory, however, integrating these new processes into a comprehensive surveillance system presents significant challenges. Many of these new technologies are still in early stages of development, require multidisciplinary teams to support them, and must undergo significant optimization presenting significant barriers to their rapid adoption despite the pressing need to understand and control antibiotic resistance. Data from the prototype MRSA surveillance process show significant variation at the DNA level between patient cases, providing evidence for the urgent need for a DNA sequencing based microbial surveillance process as part of clinical microbiology efforts in the US healthcare system. However, results of applying the process design methodology and MDPM model analysis indicate significant work remains to reduce complexity, further improve key technology elements, gain acceptance, develop key organizational infrastructure, and Page 3 of 385 redesign the process to efficiently absorb the rapid technology change expected in DNA sequencing. The MDPM model is used to develop a roadmap of specific multi-domain projects addressing these issues to accelerate the deployment of a national DNA sequencing based surveillance system.
by Robert Nicol.
Ph.D.
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Morgan, Clinton Alan. "A domain specific language for encoding design rules." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/32115.
Full textAbstract:
Design rules express constraints on the behavior and structure of a program.
These rules can help ensure that a program follows a set of established
practices, and avoids certain classes of errors.
Design rules often crosscut program structure and enforcing them is
emerging as an important application domain for Aspect Oriented Programming.
For many interesting design rules, current general purpose AOP languages
lack the expressiveness to characterize them statically and enforce
them at compile time.
We have developed a domain specific language called Program Description
Logic (PDL). PDL allows succinct declarative definitions of programmatic
structures which correspond to design rule violations. PDL is based
on a fully static and expressive pointcut language. PDL pointcuts allow
characterizing a wide range of design rules without sacrificing static verification.
We evaluate PDL by comparing it to FxCop, an industrial strength tool
for checking design rules.Science, Faculty of
Computer Science, Department of
Graduate
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Tucker, Andrew J. "Design of perturbation signals and their application to autotune control." Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246759.
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Milley, Andrew J. "Computer-Aided Design and Frequency Domain Analysis of Sampling Circuits." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1242665614.
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Lau, P. H. "Computer aided design of microelectronic systems in the time domain." Thesis, University of Sunderland, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234044.
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de, Haan Sophie. "Application Design for the Quantified Pet Domain from a User Centered Design Perspective." Thesis, KTH, Medieteknik och interaktionsdesign, MID, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-235191.
Full textAbstract:
Quantifying personal information is a rapidly emerging lifestyle that has now extended to tracking non-personal information as well. The Quantified Pet (QP) domain enablespet owners to gain insights in their pet’s behavior and wellbeing. This study investigates how to design a QP application using the User Centered Design Method. To gain understanding in the inner drivers that form the human-pet relationship, five dog owners are interviewed. Three inner drivers that trigger interaction are revealed: habits, love and guilt. By surveying 104 users of existing QP applications, this study examined what motivates users to use a pet activity tracker and what sustains this usage. After performing a thematic analysis on this data, it was found that Activities,interest in activity data, and Health, improving and ensuringthe dog’s health, are dominantly portraited in the results. These themes provide the foundation for the establishment of two personas, of which the Health persona is chosen to be the primary design target. Next to user requirements following from the persona design, a heuristic evaluation is performed on one QP application (FitBark) to provide an additional set of design requirements. From these requirements, a design solution is proposed and evaluated amongst ten participants by means of a task list, semi- structured interview and a questionnaire. This revealed high usability for navigation and successful implementation of most requirements. However, design flaws, in specific of data visualization, and some misunderstanding of informational components remain. Future work proposes an improved design and provides additional suggestions for implementation and examination.Att kvantifiera personlig information är en starkt växande uppkommande livsstil och har nu även utökats till att följa icke-personlig information. Quantified Pet (QP) domänen möjliggör husdjursägare att få insikter i deras husdjurs beteende och välmående. I denna studie undersöks hur en QP-applikation ska designas genom att använda metoden User Centered Design. För att få förståelse för de innersta drivkrafterna till det som formar relationen mellan människa och husdjur blev fem hundägare intervjuade. Tre innre drivkrafter som triggar interactionen klarlades: vanor, kärlek och skuldkänslor. Genom att studera 104 användare av redan existerande QP-applikationer, denna studie undersökte vad som motiverar användare till att använda en pet activity tracker och vad som upperäthåller ett fortsatt användande. Efter att ha genomfört en tematisk analys av denna data visade det sig att Aktiviteter, intresse av aktivitetsdata, och Hälsa, förbättra och säkerställa hundens hälsa är de mest framträdande i resultaten. Dessa teman bidrar till grunden för etableringen av två personas, där personan för Hälsa är vald som primärt mål för designen. Utöver de användarkrav som uppkommit från personadesignen, har en hueristisk evaluering av en QR-applikation (Fitbark) gjorts för att bidra till ett ytterligare antal designkrav. Utifrån dessa krav föreslås en designlösning som evalueras bland tio deltagare genom en uppdragslista, semistrukturerad intervju och frågeformulär. Detta visade på en hög användbarhet för navigering och en lyckad implementation av de flesta av kraven. Dock existerar fortfarande brister i designen, specifikt för datavisualisering och några missförstånd över informationskomponenter. Framtida arbeten föreslår en förbättrad design och bidrar med ytterligare förslag på implementation och examinering.
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Haddadin, Baker. "Time domain space mapping optimization of digital interconnect circuits." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116004.
Full textAbstract:
Microwave circuit design including the design of Interconnect circuits are proving to be a very hard and complex process where the use of CAD tools is becoming more essential to the reduction in design time and in providing more accurate results. Space mapping methods, the relatively new and very efficient way of optimization which are used in microwave filters and structures will be investigated in this thesis and applied to the time domain optimization of digital interconnects. The main advantage is that the optimization is driven using simpler models called coarse models that would approximate the more complex fine model of the real system, which provide a better insight to the problem and at the same time reduce the optimization time. The results are always mapped back to the real system and a relation/mapping is found between both systems which would help the convergence time. In this thesis, we study the optimization of interconnects where we build certain practical error functions to evaluate performance in the time domain. The space mapping method is formulated to avoid problems found in the original formulation where we apply some necessary modifications to the Trust Region Aggressive Space Mapping TRASM for it to be applicable to the design process in time domain. This new method modified TRASM or MTRASM is then evaluated and tested on multiple circuits with different configuration and the results are compared to the results obtained from TRASM.
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Liu, Yunhui. "Hierarchical modularization and dual-domain formation for product adaptability." Development of an open-architecture electric vehicle using adaptable design, 2014. http://hdl.handle.net/1993/32027.
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Product adaptability is the capability to adjust a product by adding/replacing its constitu-ents for different applications. To acquire this capability, a product should be a modular structure that can form different modular combinations. The purpose of this thesis is pro-posing a design method to develop such products. The method includes the following characteristics: a product essentially implements its applications by providing proper ac-tions/reactions to interact with its surrounding conditions; such actions/reactions can be used to develop the subsystems of a product by building energy-flow or force-path con-nections; optional modules can be separated from the subsystems that contain optional applications; all modules are arranged as an open architecture to provide space and inter-face for each optional module; and each module is endued with the principal content of actions/reactions, inside energy flows or force paths, space, and interfaces constraints, so that it can be physically formed through a dual-domain formation process. Following this method, a multi-purpose electric vehicle (MEV) is developed. Adaptability Efficacy (AE) is proposed to evaluate the effectiveness of the proposed method.February 2017
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Debaud, Jean-Marc. "The construction of software systems using domain-specific reuse infrastructures." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/8154.
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