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Dissertations / Theses on the topic 'Designer drugs of abuse'

Author: Grafiati

Published: 24 April 2022

Last updated: 30 July 2025

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1

Lindauer, Carina Verfasser], and Hans H. [Akademischer Betreuer] [Maurer. "Toxicokinetics of Emerging Drugs of Abuse : In vivo and in vitro studies on the metabolic fate of the cocaine-derived designer drug dimethocaine / Carina Lindauer. Betreuer: Hans H. Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2015. http://d-nb.info/1067841555/34.

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2

Prosser, Denise Verfasser], and Hans H. [Akademischer Betreuer] [Maurer. "Toxicocinetics of Emerging Drugs of Abuse : In vivo and in vitro studies on the metabolic fate of the cathinone-derived designer drug ß-naphyrone / Denise Prosser. Betreuer: Hans H. Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2014. http://d-nb.info/1053983018/34.

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3

Rosenbaum, Christopher D. "Herbal Marijuana Alternatives Investigation: K2 and Spice: A Masters Thesis." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/578.

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Background Herbal marijuana alternatives (HMA), legal plant products adulterated with synthetic cannabinoid receptor agonists, represent a growing public health concern. Only a few case reports describe HMA and synthetic cannabinoid’s clinical toxicity. We describe an outbreak of HMA abuse primarily in the Midwest, the clinical presentation of HMA toxicity, and clinical and forensic testing. Methods During the course of ongoing surveillance for emerging drugs of abuse between November 2009 and August 2010, we retrospectively and prospectively identified a convenience sample comprising 81 cases

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4

Swortwood, Madeleine Jean. "Comprehensive Forensic Toxicological Analysis of Designer Drugs." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/997.

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New designer drugs are constantly emerging onto the illicit drug market and it is often difficult to validate and maintain comprehensive analytical methods for accurate detection of these compounds. Generally, toxicology laboratories utilize a screening method, such as immunoassay, for the presumptive identification of drugs of abuse. When a positive result occurs, confirmatory methods, such as gas chromatography (GC) or liquid chromatography (LC) coupled with mass spectrometry (MS), are required for more sensitive and specific analyses. In recent years, the need to study the activities of the

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5

Jebadurai, Jeshoor Kumar. "Qualitative research of online drug misuse communities with reference to the novel psychoactive substances." Thesis, University of Hertfordshire, 2013. http://hdl.handle.net/2299/11352.

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Objective: This research aimed at reviewing the information provided by the online drug misuse communities with reference to the available evidence-based literature on the novel psychoactive substances. Methodology: Among hundreds of novel psychoactive substances, four groups (phenethylamines, tryptamines, piperazines and miscellaneous) were selected for the study. Various website drug fora were identified by Google and Yahoo search engines using a set of specific key words. The methods consisted of extracting and analysing qualitative data from the identified website fora. This was also suppl

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6

Beckett, Nicola Michelle. "Isotopic Profiling of Selected Designer Drugs for Forensic Intelligence Purposes." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/366425.

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Driven by forensic intelligence, illicit drug chemical profiling via Gas Chromatography-Mass Spectrometry (GC-MS) remains the leading approach that forensic scientists and law enforcement agencies pursue in a bid to counteract the ever-increasing drug epidemic. An alternative approach for forensic drug investigations that delivers intelligence at a more specific level than that of chemical profiling is isotopic profiling via Isotope Ratio Mass Spectrometry (IRMS). The analysis of selected stable isotopes (18O:16O,15N:14N, 13C:12C and 2H:1H, for example) that compose drug molecules has

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7

Xiang, Ping. "Hair analysis for drugs of abuse." Thesis, University of Central Lancashire, 2011. http://clok.uclan.ac.uk/3031/.

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This thesis covers a range of important issues in hair analysis and includes 27 scientific works in which the name of the candidate was either listed as the first author or as the major contributor. The work presented in this thesis involved the development of a series of analytical methods to detect trace amounts of drugs in hair and also investigated the mechanisms by which drugs may be incorporated into hair. The major areas covered in this study can be summarized as follows: 1. The methods for the identification and quantification of opiates, amphetamines, ketamine, cannabis, cocaine, benz

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8

Taylor, Carolyn. "Multi-analyte immunoassays for drugs of abuse." Thesis, University of Sunderland, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251355.

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Currently, many methods are available for the analysis of drugs of abuse in urine but they all have their drawbacks. Thus, the purpose of this research was to overcome some of these drawbacks by developing multi-analyte detection systems based on sequential or spatial techniques and immunoassays. The first system was based on a spatial technique and involved a simple indirect competitive ELISA format. This produced relatively rapid multi-analyte dip-strip ELISAs for benzoylecgonine (BE), methadone (MET) and morphine (MOR). Various enzyme-labelled antibodies, substrates and filters were investi

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9

Sarhan, Hashim Abdullah Sulaiman. "Drugs abuse in the United Arab Emirates." Thesis, University of Newcastle Upon Tyne, 1995. http://hdl.handle.net/10443/173.

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Many aspects of life have changed rapidly since the independence of the United Arab Emirates (U.A.E.) in 1971. The economic and social changes have catapulated people from a nomadic and isolated life into a relatively luxurious lifestyle. Many of the traditional values of the indigenous people have changed and came to be influenced by the values and attitudes of those who came to work in the U.A.E. The rapid social change has been an important factor behind the appearance of many types of anti-social behaviour, of which drug use is one. As in most countries throughout the world, illicit drug u

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10

Schneider, Kevin. "Covalent Protein Adduction by Drugs of Abuse." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/816.

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Recreational abuse of the drugs cocaine, methamphetamine, and morphine continues to be prevalent in the United States of America and around the world. While numerous methods of detection exist for each drug, they are generally limited by the lifetime of the parent drug and its metabolites in the body. However, the covalent modification of endogenous proteins by these drugs of abuse may act as biomarkers of exposure and allow for extension of detection windows for these drugs beyond the lifetime of parent molecules or metabolites in the free fraction. Additionally, existence of covalently bound

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11

Abbott, R. W. "HPLC of drugs of abuse with chemiluminescence detection." Thesis, University of Hull, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384671.

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12

Kampouris, Dimitrios. "Developing novel sensors for sensing drugs of abuse." Thesis, Manchester Metropolitan University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534245.

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13

Lynch, Wesley W. "Adolescent Substance Abuse Screening." ScholarWorks, 2020. https://scholarworks.waldenu.edu/dissertations/7880.

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Adolescent substance use is a key public health problem in rural Ohio. Primary care nurses lack substance use screening knowledge and skills. Early screening and detection of possible substance use issues aids in directing patients to appropriate health services. This project involved the implementation of an educational intervention on the CRAFFT screening tool for primary care nurses in rural Ohio. Guided by Kurt Lewin's 3-step model to emphasize prevalence of substance use and need for screening among adolescents, the purpose of this project was to provide training on the CRAFFT screening a

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14

Pruyn, Marley. "Qualitative Detection of Selected Designer Drugs and Relevant Metabolites in Environmental Water Samples." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2571.

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Designer drugs are compounds which have been synthetically derived from illicit drugs. After consumption, drugs and their metabolites are introduced into the sewage water which is treated and disposed into the environment. A combined target, suspect and non-target workflow was created to detect designer drugs in environmental water samples. Multiple water samples were spiked with an unknown mixture of drugs and metabolites to assess the efficiency of the method. Samples were collected from sewage influent and effluent pipes, downstream from a sewage outfall and reclaimed water. Analysis was co

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15

Xue, Liu. "HIGH-ACTIVITY MUTANTS OF HUMAN BUTYRYLCHOLINESTERASE FOR COCAINE ABUSE TREATMENT." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/40.

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Cocaine is a widely abused drug without an FDA-approved medication. It has been recognized as an ideal anti-cocaine medication to accelerate cocaine metabolism producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway, i.e. butyrylcholinesterase (BChE)-catalyzed hydrolysis. However, the native BChE has a low catalytic activity against cocaine. We recently designed and discovered a set of BChE mutants with a high catalytic activity specifically for cocaine. An ideal, therapeutically valuable mutant of human BChE should have not only a significan

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16

Alibhai, Imran Nizamudin. "Regulation of FOSB MRNA isoforms by drugs of abuse." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2005. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=144.

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17

Alshamaileh, M. Y. "Novel strategies for the analysis of drugs of abuse." Thesis, University of Lincoln, 2016. http://eprints.lincoln.ac.uk/23695/.

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The data presented in this thesis has been organized in three parts: First part included the development and validation of a quantitative HPLC-DAD analytical method of mephedrone after extraction from spiked whole blood and serum samples, alone and with methcathinone. The second part included in vitro metabolism of mephedrone and other NPS, which are methoxetamine and methcathinone, using an in-house prepared in vitro metabolic system, namely liver microsomes, followed by performing analysis for the drugs and their proposed metabolites utilizing LC-MS. Third part included in vitro studies of s

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18

Raine, Pamel Mary. "Different dimensions : women's perspectives on alcohol and drugs." Thesis, Lancaster University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310359.

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This thesis explores aspects of the experience of alcohol and drug problems which are unique to women, and specifically factors relating to the problematising of such experiences, and help-seeking. Drawing on feminist methodology, in-depth interviews were conducted with 23 women, self-identified as problem alcohol and/or drug users, seventeen of whom were in residential treatment at the time of the study. Ten senior alcohol and drug agency staff were also interviewed. The five main topic areas addressed in the thesis are as follows: chaos; control; problem recognition; professional responses;

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19

KILL, J. B. "O Que São Designer Drugs? Explorando a Sua Composição Química Por Espectrometria de Massas." Universidade Federal do Espírito Santo, 2016. http://repositorio.ufes.br/handle/10/7336.

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Made available in DSpace on 2018-08-01T21:58:47Z (GMT). No. of bitstreams: 1 tese_10379_Jade Barbosa Kill.pdf: 4071282 bytes, checksum: 7e014389d0a7130698dfc8f7e0394cf5 (MD5) Previous issue date: 2016-11-18<br>As designer drugs são drogas sintetizadas a fim de reproduzirem os efeitos farmacológicos das substâncias regulamentadas e dificultar as estratégias mundiais de controle devido à sua estrutura química modificada. O aparecimento dessas substâncias, com informações toxicológicas e de riscos de overdose muitas vezes inexistentes, é um grande desafio para o governo e as leis de controle na

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20

Mathis, Stephanie M., Robert P. Pack, and Billy Brooks. "Non-Medical Use of Prescription Drugs in the Workplace." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/3202.

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Background: University scholars and community members formed the Prescription Drug Abuse and Misuse Working Group in response to the prescription drug abuse/misuse epidemic plaguing the Appalachian region. Their collaboration has yielded no fewer than four funded and six volunteer service projects in the community. A concern voiced by key community stakeholders has been the non-medical use of prescription drugs (NMUPD) among the workforce. The team discovered that the relationship between NMUPD and workplace characteristics is understudied. This study aimed to show the overall and industry-spe

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21

Jalava, Anna-Kaisa. "Profiling of drugs of abuse : a new method for amphetamine." Thesis, University of Strathclyde, 2002. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21160.

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In the literature survey, a summary of chemical impurity profiling methods is presented for the most common drugs. These include cannabis, LSD, heroin, cocaine and amphetamine-type stimulants. The survey also details the statistical techniques commonly used for profiling. The main aim of the experimental work was carried out as part of a European project to develop a harmonised amphetamine profiling method which could be applied at national laboratories utilising an international database. The optimisation of the method was divided into four steps including (i) identification and synthesis of

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22

Lamping, Sarah Louise. "Study of SERS for the detection of drugs of abuse." Thesis, University of Strathclyde, 2008. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21989.

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A study of the use of Surface Enhanced Raman Spectroscopy (SERS) for the detection of illicit drugs in oral fluid using metal enhancement mechanisms was undertaken. Initial work investigated ecstasy tablet composition using Raman to identify what drugs and excipients might be present in oral fluid samples obtained from users. Overall, it is possible to identify the presence of phenethylamines and excipients in the seized tablets but not categorically distinguish between the phenethylamine derivative(s) especially when in a mixture. Comparison of the overall batch average peak positions and pea

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23

Fingleton, Niamh Ann. "Non-prescription medicine misuse, abuse and dependence in the UK." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231007.

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Background: Non-prescription medicines (NPMs) may be misused, abused and lead to dependence. Aims and methods • To determine the prevalence of self-reported NPM misuse, abuse and dependence in the general population and to explore factors predictive of misuse or abuse using a cross-sectional postal survey (n=411). • To identify the perceived barriers and enablers to seeking treatment for NPM dependence using qualitative semi-structured interviews with individuals dependent on NPMs (n=8). • To establish how NPM dependence is managed by specialist clinicians using an online survey (n=83) and to

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24

Pack, Robert P. "Prescription Drug Abuse." Digital Commons @ East Tennessee State University, 2009. https://dc.etsu.edu/etsu-works/6338.

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25

Lewis, J. Ben. "POLYAMINE MODULATION IN ALCOHOLISM: EXAMINATION USING A NOVEL SCREENING PROCEDURE DESIGNED TO PREDICT ANTI-RELAPSE AND NEUROPROTECTIVE EFFICACY." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/851.

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Alcohol dependence is a major public health concern. Despite the FDA’s approval of multiple anti-relapse drugs, relapse rates remain unacceptably high. Furthermore, cognitive deficits among chronic drinkers are evident and are suggested to contribute to relapse risk. Current evidence suggests that several critical features of alcoholism and alcohol-associated neurodegeneration are mechanistically linked to glutamatergic actions; specifically, they appear positively affected by glutamatergic inhibition, particularly inhibition via polyamine modulation of a subpopulation of n-methyl-d-aspartate

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26

Faulds, Karen Jade. "Detection of drugs of abuse by surface enhanced Raman scattering (SERS)." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288636.

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27

Gersper, Beth E. "NETWORK ANALYSIS OF DRUGS OF ABUSE IN OHIO AND POLICY IMPLICATIONS." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron156761393419992.

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28

Badiru, Shewu Oladapo. "Chromatographic studies on the detection of some basic drugs of abuse." Thesis, University of Bath, 1989. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234086.

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29

Dinger, Julia Verfasser], and Hans H. [Akademischer Betreuer] [Maurer. "Hepatic cytochrome P450 inhibition by designer drugs and their metabolites / Julia Dinger. Betreuer: Hans H. Maurer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1088400094/34.

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30

Chan, Kin-yi Ivy. "A study of determinants of relapse in psychotropic substance abuse /." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19470757.

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31

Botello, González Igor. "Sensitivity enhancement strategies in capillary electrophoresis for the determination of drugs of abuse and non-steroidal anti-inflammatory drugs." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/90245.

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La electroforesis capilar presenta menos sensibilidad en términos de concentración, comparado con la cromatografía de líquidos debido principalmente al pequeño volumen de inyección de la muestra y a la pequeña longitud del camino óptico para la detección, el cual coincide con el diámetro interno del capilar. El objetivo de la presente Tesis es el estudio y desarrollo de diferentes estrategias para disminuir los límites de detección de la electroforesis capilar, concretamente técnicas de preconcentración electroforéticas y cromatográficas. Se presentan técnica basadas en isotacoforesis y SPE a

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32

Lieb, Roselind, Hildegard Pfister, and Hans-Ulrich Wittchen. "Use, Abuse and Dependence of Prescription Drugs in Adolescents and Young Adults." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-99916.

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Lifetime prevalence estimates of psychotropic medicine use as well as prevalence of DSM-IV prescription drug use disorders from the baseline investigation of the Early Developmental Stages of Psychopathology (EDSP) Study are presented. Use of prescription medication at some time in their life was reported by 27.4% of the respondents. Illicit use of prescription drugs, which means an intake without medical legitimation, was reported by 4.5% of the sample. The findings suggest that abuse of and dependence on prescription drugs, with most cases reporting polysubstance use, is quite rare in the 14

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33

Guerra, Maria Romero. "Development of molecularly imprinted polymers for drugs of abuse and sensor applications." Thesis, Cranfield University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443743.

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34

Wilson, Lisa. "Immunological analysis of drugs of abuse with reference to anhydroecgonine methyl ester." Thesis, Sheffield Hallam University, 2007. http://shura.shu.ac.uk/20704/.

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The field of forensic drug testing is continually changing with analytical methodology being developed for an increasing number of drugs in a variety of biological matrices. The aim of this thesis was to develop a novel enzyme immunoassay (EIA) for screening oral fluid specimens for the presence of anhydroecgonine methyl ester (AEME), a pyrolysis product of cocaine. A confirmatory method was also to be developed to accurately quantify the levels of cocaine, its metabolites and pyrolysis products in oral fluid samples. The immunoassay development was started by synthesising an immunogen using a

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35

Lieb, Roselind, Hildegard Pfister, and Hans-Ulrich Wittchen. "Use, Abuse and Dependence of Prescription Drugs in Adolescents and Young Adults." Karger, 1998. https://tud.qucosa.de/id/qucosa%3A26268.

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Lifetime prevalence estimates of psychotropic medicine use as well as prevalence of DSM-IV prescription drug use disorders from the baseline investigation of the Early Developmental Stages of Psychopathology (EDSP) Study are presented. Use of prescription medication at some time in their life was reported by 27.4% of the respondents. Illicit use of prescription drugs, which means an intake without medical legitimation, was reported by 4.5% of the sample. The findings suggest that abuse of and dependence on prescription drugs, with most cases reporting polysubstance use, is quite rare in the 14

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36

Kgwete, Ephraim Matala. "The management of school safety with reference to drugs in public schools." Pretoria : [s.n.], 2010. http://upetd.up.ac.za/thesis/available/etd-04062010-150948.

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37

Al-Balushi, Rashid Bin Hamed. "Drugs and drug policies in Oman with special reference to the death penalty." Thesis, University of Hull, 2004. http://hydra.hull.ac.uk/resources/hull:5605.

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The problem of drugs in Oman has assumed serious proportions in recent years. It leads to creation of an underground economy and is associated with loss of skilled manpower. However, the problem has several dimensions. It has direct and indirect adverse effects. In response to increases in both worldwide drug production and drug demand in Oman, law makers in Oman instituted legal measures designed to protect the health, welfare and finance of people from the effects of drug use. In addition, law makers in Oman have recognized that trade in illicit drugs is a global activity and that drug-relat

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38

Stephens, Jason L. "Synthetic Cannabinoid Usage among College Students: The Example of K2 and Spice." Thesis, University of North Texas, 2011. https://digital.library.unt.edu/ark:/67531/metadc84283/.

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The primary goal of this study was to investigate the awareness and prevalence of Spice and K2 usage among a population of college students, as well as the demographics of such users. The study also sought to determine whether or not students prefer these products over natural cannabis, in addition to examining the most popular methods of obtainment and the most commonly reported side effects of K2 and Spice usage. Participants consisted of 643 undergraduate students enrolled at the University of North Texas during the fall 2011 semester. Findings indicate that while students exhibit a relativ

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39

Rodayan, Angela. "Presence and fate of drugs of abuse in environmental waters and engineered systems." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123005.

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The presence of contaminants of emerging concern (CECs) in environmental waters has received increasing attention over the last decade due to potential impacts on both aquatic organisms and human health. Several classes of contaminants have been added to the list of CECs being investigated, including drugs of abuse (DOAs) which are the focus of the present thesis. Target DOAs included cocaine and its active metabolite, benzoylecgonine (BE), several amphetamine drugs, as well as illicit opioid drugs or prescription opioids that are often abused. To date, the data available on the occurrence and

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40

Wang, Ling. "Applications of Paper Microfluidic Systems in the Field Detection of Drugs of Abuse." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3381.

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Over the years, colorimetric reagents and immunology have been widely used in screening tests for illicit drugs; however, the test kits are not always convenient for field use and often require the user to mix and develop a specific set of reagents. In our project, we have been working on alternative platforms based on paper microfluidic devices (uPADs) for field testing. These devices utilize wax channels printed on paper to direct the analyte towards a specific set of chemical reagents. Using the procedure, we have developed a six-channel chip that adapts known colorimetric reagents targetin

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41

Martin, Danica Paige. "Optimization of a Method for the Extraction of Drugs of Abuse from Wastewater." Bowling Green State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1617014087323429.

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42

Fruhwirth, Grant. "Minor tranquilziers [sic] and the Valium epidemic prescription drug use and abuse in the United States, 1906-1979 /." Pullman, Wash. : Washington State University, 2010. http://www.dissertations.wsu.edu/Thesis/Spring2010/g_fruhwirth_042310.pdf.

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43

McDonald, Dana N. "The relationship between alcohol abuse and sexual risk-taking behavior how it affects our society /." Online version, 1999. http://www.uwstout.edu/lib/thesis/1999/1999mcdonaldd.pdf.

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44

Schmitt, Michelle Marie. "Recovery from Substance Abuse: The Role of Unsupportive Social Interactions." VCU Scholars Compass, 2003. http://scholarscompass.vcu.edu/etd/661.

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ABSTRACTRECOVERY FROM SUBSTANCE ABUSE: THE ROLE OF UNSUPPORTIVE SOCIAL INTERATIONSBy Michelle M. Schmitt, M.A., M.S. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.Virginia Commonwealth University, 2003Major Director: Kathleen M. Ingram, Ph.D., Assistant Professor, Department of Psychology It has been estimated that over 20 million individuals struggle with substance abuse and/or dependence each year. Theories of addiction and recovery have long incorporated the notion of social support and helping

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45

Chen, Xiabin. "DEVELOPMENT OF COCAINE HYDROLASE FOR THERAPEUTIC TREATMENT OF COCAINE ABUSE." UKnowledge, 2016. http://uknowledge.uky.edu/pharmacy_etds/59.

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Cocaine abuse is a world-wide public health and social problem without a U.S. Food and Drug Administration (FDA)-approved medication. An ideal anti-cocaine medication would accelerate cocaine metabolism producing biologically inactive metabolites by administration of an efficient cocaine-specific exogenous enzyme. Recent studies in our lab have led to discovery of the desirable, highly efficient human cocaine hydrolases (hCocHs) that can efficiently detoxify and inactivate cocaine without affecting normal functions of central nervous system (CNS). Preclinical and clinical data have demonstrate

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46

Anderson, Diane Hutt. "Sexual abuse as a determinant of female amphetamine abuse." CSUSB ScholarWorks, 1993. https://scholarworks.lib.csusb.edu/etd-project/716.

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47

Guitart, Masip Marc. "Divergent Sensitivities to Drugs of Abuse: Neurochemical and Neuroanatomical Characterization of the Roman Rats." Doctoral thesis, Universitat Autònoma de Barcelona, 2006. http://hdl.handle.net/10803/3787.

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Només un petit percentatge d'entre tots els individus que experimenten amb drogues d'abús esdevenen addictes. La vulnerabilitat per a desenvolupar un trastorn addictiu està relacionada amb trets de personalitat impulsiva o amb apetència per la novetat. Les soques de rata Romanes, genèticament seleccionades per alta (RHA) o baixa (RLA) adquisició de l'evitació activa en dos sentits, són un model de laboratori vàlid de les divergències en apetència per la novetat i substàncies gratificants que s'observen en humans. A més a més, aquestes soques de rata difereixen en la funcionalitat del sistema d

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48

Mwenesongole, Ellen Musili. "Simultaneous detection of drugs of abuse in waste water using gas chromatography-mass spectrometry." Thesis, Anglia Ruskin University, 2015. http://arro.anglia.ac.uk/550378/.

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Sewage epidemiology is increasingly becoming an alternative method of estimating drug usage and consumption patterns for a given population. With the constant emergence of new psychoactive substances such as cathinones and piperazines, versatile, reliable, specific and sensitive analytical methods are needed for their detection in complex matrices such as waste water. This thesis reports the development of an analytical method based on solid phase extraction, derivatization with pentafluoropropionic anhydride and analysis by gas chromatography-mass spectrometry for the simultaneous analysis of

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Bell, Tannisha D. "An Examination of Race and Recurrent Substance Problems in the United States." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/9582.

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Several studies show that African-Americans are less likely than whites to use alcohol or drugs. However, if African-Americans use drugs then they are more likely to become heavy and persistent users. African-Americans are also more likely to have a current substance abuse disorder. There is not much in the literature to explain this phenomenon. The purpose of this study is to examine the alcohol and drug abuse, use and dependence of blacks and whites in order to explain the differences in the course of the substance disorder, using data from the National Comorbidity Survey. There are many var

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Kwan, Ming-tak Kalwan. "Drugs, peers, gangs, and crime : an interactional model /." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19470563.

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