Academic literature on the topic 'Desmocollins'

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Journal articles on the topic "Desmocollins"

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Muhammad, Javed Khan* Imran Khan Irshad Ali Sheikh Ahmed Ghulam Mustafa Khan. "A REVIEW ON DESMOGLEINS, DESMOCOLLINS AND ASSOCIATED DISEASES." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4053–61. https://doi.org/10.5281/zenodo.1045425.

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In most epithelia, desmosomes are important adhesion structures which have a key role in linking the intermediate filament network of one cell to its neighbor, thus forming a strong bond. These junctions are essential for retaining the integrity of organs, subject to mechanical stress, particularly the heart and skin. Desmogleins and desmocollins belong to super family of cadherin, which mediate adhesion at desmosomes. Through a series of protein interactions, desmosomal cadherin tails get associated with Cytoplasmic components of the desmosome, the sites of desmosome assemblage are employed w
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Marcozzi, C., I. D. Burdett, R. S. Buxton, and A. I. Magee. "Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion." Journal of Cell Science 111, no. 4 (1998): 495–509. http://dx.doi.org/10.1242/jcs.111.4.495.

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Desmosomes are unique intercellular junctions in that they invariably contain two types of transmembrane cadherin molecule, desmocollins and desmogleins. In addition they possess a distinct cytoplasmic plaque structure containing a few major proteins including desmoplakins and the armadillo family member plakoglobin. Desmosomal cadherins are putative cell-cell adhesion molecules and we have tested their adhesive capacity using a transfection approach in mouse L cells. We find that L cells expressing either one or both of the desmosomal cadherins desmocollin 2a or desmoglein 1 display weak cell
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Wahl, James K. "Desmogleins and Desmocollins as Adhesive Molecules." Journal of Investigative Dermatology 127 (January 2007): E10. http://dx.doi.org/10.1038/sj.skinbio.6250003.

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Legan, P. K., K. K. Yue, M. A. Chidgey, J. L. Holton, R. W. Wilkinson, and D. R. Garrod. "The bovine desmocollin family: a new gene and expression patterns reflecting epithelial cell proliferation and differentiation." Journal of Cell Biology 126, no. 2 (1994): 507–18. http://dx.doi.org/10.1083/jcb.126.2.507.

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We have discovered a third bovine desmocollin gene, DSC3, and studied expression of all three desmocollin genes, DSC1, 2, and 3, by Northern blotting, RT-PCR and in situ hybridization. DSC1 is strongly expressed in epidermis and tongue papillae, showing a "skin"-type pattern resembling that previously described for keratins 1 and 10. Expression is absent from the epidermal basal layer but appears in the immediate suprabasal layers and continues uniformly to the lower granular layer. In tongue epithelium, expression is suprabasal and strictly localized to papillae, being absent from interpapill
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Arnemann, J., K. H. Sullivan, A. I. Magee, I. A. King, and R. S. Buxton. "Stratification-related expression of isoforms of the desmosomal cadherins in human epidermis." Journal of Cell Science 104, no. 3 (1993): 741–50. http://dx.doi.org/10.1242/jcs.104.3.741.

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Desmosomal junctions are abundant in epidermis and contain two classes of transmembrane glycoprotein, the desmocollins and the desmogleins, which are members of the cadherin superfamily of Ca(2+)-dependent cell adhesion molecules. The desmocollin subfamily includes DGIV/V and DGII/III while the desmoglein subfamily includes DGI, HDGC and the autoantigen of the blistering skin disease pemphigus vulgaris (PVA). There are also several non-glycosylated proteins, including the desmoplakins and plakoglobin, present in the desmosomal plaque, which forms a link between the glycoproteins and the cytoke
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North, A. J., W. G. Bardsley, J. Hyam, et al. "Molecular map of the desmosomal plaque." Journal of Cell Science 112, no. 23 (1999): 4325–36. http://dx.doi.org/10.1242/jcs.112.23.4325.

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Recent biochemical and molecular approaches have begun to establish the protein interactions that lead to desmosome assembly. To determine whether these associations occur in native desmosomes we have performed ultrastructural localisation of specific domains of the major desmosomal components and have used the results to construct a molecular map of the desmosomal plaque. Antibodies directed against the amino- and carboxy-terminal domains of desmoplakin, plakoglobin and plakophilin 1, and against the carboxy-terminal domains of desmoglein 3, desmocollin 2a and desmocollin 2b, were used for im
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Müller, R., B. Heber, T. Hashimoto, et al. "Autoantibodies against desmocollins in European patients with pemphigus." Clinical and Experimental Dermatology 34, no. 8 (2009): 898–903. http://dx.doi.org/10.1111/j.1365-2230.2009.03241.x.

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Yue, K. K., J. L. Holton, J. P. Clarke, et al. "Characterisation of a desmocollin isoform (bovine DSC3) exclusively expressed in lower layers of stratified epithelia." Journal of Cell Science 108, no. 6 (1995): 2163–73. http://dx.doi.org/10.1242/jcs.108.6.2163.

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Desmocollins are cadherin-like glycoproteins involved in cell adhesion and plaque formation in desmosome junctions. Three distinct isoforms, the products of different genes, have been found in bovine tissues. We have reported previously that one of these, DSC3, is expressed only in basal and lower suprabasal layers of stratified epithelia. Using RT-PCR we have now obtained the complete cDNA coding sequence of mature bovine DSC3. It has alternatively spliced ‘a’ and ‘b’ forms found in other desmocollins but is unique in having a 43 instead of a 46 base pair exon. We have characterised a monoclo
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Harrison, Oliver J., Julia Brasch, Gorka Lasso, et al. "Structural basis of adhesive binding by desmocollins and desmogleins." Proceedings of the National Academy of Sciences 113, no. 26 (2016): 7160–65. http://dx.doi.org/10.1073/pnas.1606272113.

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Desmosomes are intercellular adhesive junctions that impart strength to vertebrate tissues. Their dense, ordered intercellular attachments are formed by desmogleins (Dsgs) and desmocollins (Dscs), but the nature of trans-cellular interactions between these specialized cadherins is unclear. Here, using solution biophysics and coated-bead aggregation experiments, we demonstrate family-wise heterophilic specificity: All Dsgs form adhesive dimers with all Dscs, with affinities characteristic of each Dsg:Dsc pair. Crystal structures of ectodomains from Dsg2 and Dsg3 and from Dsc1 and Dsc2 show bind
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Cui, Tiantian, Yuan Chen, Linlin Yang, et al. "Diagnostic and prognostic impact of desmocollins in human lung cancer." Journal of Clinical Pathology 65, no. 12 (2012): 1100–1106. http://dx.doi.org/10.1136/jclinpath-2011-200630.

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Dissertations / Theses on the topic "Desmocollins"

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Rimpler, Ute. "Funktionelle Charakterisierung von Desmocollin 2 während der Embryonalentwicklung und im adulten Herzen in der Maus." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/16878.

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Desmosomen sind hochorganisierte Zell-Zell-Verbindungen. Aufgrund ihrer hohen Adhäsivität sind sie für die mechanische Kopplung und strukturelle Stabilität stark beanspruchter Gewebe von essentieller Bedeutung. Die adhäsive interzelluläre Kernstruktur der Desmosomen wird durch die transmembranen Cadherine des Desmocollin und Desmoglein-Typs gebildet. Deren extrazelluläre Domänen stellen den Kontakt zwischen zwei benachbarten Zellen her. Dsc2 ist neben Dsg2 die prädominante Isoform und wird in allen Desmosomen-bildenden Geweben wie auch dem Herzen exprimiert. Ziel der Arbeit war es, die Rolle
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Rafei-Shamsabadi, David Ali [Verfasser], and Rüdiger [Akademischer Betreuer] Eming. "Characterization of pathogenic auto-antibodies directed against desmoglein 3 and desmocollin 3 in sera of pemphigus patients / David Ali Rafei-Shamsabadi. Betreuer: Rüdiger Eming." Marburg : Philipps-Universität Marburg, 2013. http://d-nb.info/1042276072/34.

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Rimpler, Ute [Verfasser], Thomas [Akademischer Betreuer] Sommer, Ludwig [Akademischer Betreuer] Thierfelder, and Silke [Akademischer Betreuer] Sperling. "Funktionelle Charakterisierung von Desmocollin 2 während der Embryonalentwicklung und im adulten Herzen in der Maus / Ute Rimpler. Gutachter: Thomas Sommer ; Ludwig Thierfelder ; Silke Sperling." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://d-nb.info/104690387X/34.

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Huang, Shihting, and 黃士庭. "Desmocollin-2 (DSC2) Inhibit Proliferation and Migration Ability in Human Lung Cancer Cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/57537055713769055304.

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碩士<br>大葉大學<br>分子生物科技學系碩士班<br>100<br>Lung cancer is the most common cause of cancer death in the world, and lung cancer patients death mainly due to metastasis. The process of metastasis have many complex mechanisms involved, consist of many different functional genes. The main purpose of this study is screening with lung cancer metastasis-related genes, and thus further explore the molecular mechanisms of cancer metastasis. Previously, using microarray assay and lung cancer metastasis model cell lines, screening with cancer metastasis-related genes. Additionally, we focus on cancer metastasis-
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Ou, Po-Chun, and 歐柏均. "Desmocollin-2 (DSC2) Inhibits Human Lung Cancer Cell Migration and Invasion by Down-Regulation of NDRG1." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/71940014884532307522.

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碩士<br>大葉大學<br>分子生物科技學系碩士班<br>102<br>Desmocollin-2 (DSC2) associated with cancer metastasis. DSC2 gene is one of the desmosome family, desmosome is a transmembrane protein that plays an important role in cell adhesion. Reduced expression of DSC2 has been reported in colorectal cancer, breast cancer and oesophageal squamous cell carcinoma. Suggesting that DSC2 may play a role in the development and progression of cancer. In preliminary results, we found that DSC2 gene expression levels in lung cancer cells were negatively correlation with the invasion activity of a panel of lung cancer cell line
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Chen, Yu-Yi, and 陳祐翊. "The Studies of Biological Function and Downstream Regulation of Desmocollin-2 (DSC2) Gene in Lung Cancer Cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/41296178228497326406.

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碩士<br>大葉大學<br>分子生物科技學系碩士班<br>101<br>Lung cancer is the most common cause of cancer death in the world, lung cancer patients died mainly due to metastasis, the lack of treatment of lung cancer diagnostic biomarkers transfer. Thus lung metastasis has been a major research goal. Desmosome are cell adhesion structures, many research now believe desmosome is the signal center. Desmocollin-2 (DSC2) is a transmembrane protein as the one of main component of the desmosomal proteins, major distribution in the epithelial cells. Recent studies indicate DSC2 in colorectal cancer, stomach cancer, oral canc
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Heber, Barbara [Verfasser]. "Etablierung eines ELISAs zum Nachweis von Autoantikörpern gegen Desmocollin 1, 2 und 3 in Seren von Patienten mit Pemphigus-Erkrankung / vorgelegt von Barbara Heber." 2010. http://d-nb.info/1004214375/34.

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Books on the topic "Desmocollins"

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Legan, Paul Kevin. The Desmocollin family of adhesion molecules: Desmosomal cadherins showing tissue and differentiation specific patterns of expression. University of Manchester, 1993.

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Syrris, Petros, and Alexandros Protonotarios. Arrhythmogenic right ventricular cardiomyopathy: genetics. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0359.

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Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disorder of the heart muscle which is typically inherited in an autosomal dominant manner. It is believed to be familial in over 50% of cases. A recessive mode of inheritance has also been reported in syndromic cases with cardiocutaneous features. The classic form of the disorder is considered to be ‘a disease of the desmosome’ as pathogenic variants have been identified in five genes encoding key desmosomal proteins: plakoglobin, desmoplakin, plakophilin-2, desmoglein-2, and desmocollin-2. Mutations in these genes account for 30–50%
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Book chapters on the topic "Desmocollins"

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"Desmocollins." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_4332.

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"Desmocollin." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_1575.

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Isacke, Clare M., and Michael A. Horton. "Desmocollin 1." In The Adhesion Molecule FactsBook. Elsevier, 2000. http://dx.doi.org/10.1016/b978-012356505-1/50019-8.

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Isacke, Clare M., and Michael A. Horton. "Desmocollin 2." In The Adhesion Molecule FactsBook. Elsevier, 2000. http://dx.doi.org/10.1016/b978-012356505-1/50020-4.

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Isacke, Clare M., and Michael A. Horton. "Desmocollin 3." In The Adhesion Molecule FactsBook. Elsevier, 2000. http://dx.doi.org/10.1016/b978-012356505-1/50021-6.

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"Autoantikörper gegen Desmocollin." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_310441.

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Shukla, Chandreshwar, Nayan K. Jain, and Bakulesh Khamar. "Desmocollin-3 and Cancer." In Frontiers in Clinical Drug Research - Anti-Cancer Agents: Volume 8. BENTHAM SCIENCE PUBLISHERS, 2021. http://dx.doi.org/10.2174/9781681089317121080006.

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Pilichou, Kalliopi, Cristina Basso, Rudy Celeghin, and Gaetano Thiene. "Genetics of cardiomyopathies: arrhythmogenic right ventricular cardiomyopathy." In ESC CardioMed. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0157.

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Arrhythmogenic cardiomyopathy (AC) is characterized by progressive non-ischaemic cardiomyocyte death and fibro-fatty repair, triggering ventricular arrhythmias and sudden death. A familial background consistent with an autosomal dominant trait of inheritance is described in nearly half of AC patients, even if recessive variants have also been reported, either associated or not with palmoplantar keratosis and woolly hair. Advances in DNA sequencing have led to the identification of more than 350 pathogenic mutations in 15 disease-causing genes associated with AC. Nearly half of patients with AC
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Pilichou, Kalliopi, Cristina Basso, Rudy Celeghin, and Gaetano Thiene. "Genetics of cardiomyopathies: arrhythmogenic right ventricular cardiomyopathy." In ESC CardioMed. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0157_update_001.

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Arrhythmogenic cardiomyopathy (AC) is characterized by progressive non-ischaemic cardiomyocyte death and fibro-fatty repair, triggering ventricular arrhythmias and sudden death. A familial background consistent with an autosomal dominant trait of inheritance is described in nearly half of AC patients, even if recessive variants have also been reported, either associated or not with palmoplantar keratosis and woolly hair. Advances in DNA sequencing have led to the identification of more than 350 pathogenic mutations in 15 disease-causing genes associated with AC. Nearly half of patients with AC
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Syrris, Petros, and Alexandros Protonotarios. "Arrhythmogenic right ventricular cardiomyopathy: genetics." In ESC CardioMed. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0359_update_001.

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Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disorder of the heart muscle which is typically inherited in an autosomal dominant manner. It is believed to be familial in over 50% of cases. A recessive mode of inheritance has also been reported in syndromic cases with cardiocutaneous features. The classic form of the disorder is considered to be ‘a disease of the desmosome’ as pathogenic variants have been identified in five genes encoding key desmosomal proteins: plakoglobin, desmoplakin, plakophilin-2, desmoglein-2, and desmocollin-2. Mutations in these genes account for 30–50%
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Conference papers on the topic "Desmocollins"

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Flemming, S., AC Luissint, D. Kusters, et al. "Intestinal exprimiertes Desmocollin-2 reguliert die intestinal-mukosale Wundheilung durch Modifikation der Zell-Zellmatrix-Adhäsion." In Viszeralmedizin 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1695148.

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Hsu, Yu-Chih, Po-Chun Ou, Yu-Yi Chen, and Meng-Feng Tsai. "Abstract 4989: Desmocollin 2 suppresses lung cancer cell migration and invasion through down-regulation of NDRG1 expression." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4989.

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Anami, Katsuhiro, Naohide Oue, Naoya Sakamoto, et al. "Abstract 235: Desmocollin 2 (DSC2), identified by CAST method, is associated with intestinal phenotype of gastric cancer." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-235.

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Reports on the topic "Desmocollins"

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Hansen, Peter J., and Amir Arav. Embryo transfer as a tool for improving fertility of heat-stressed dairy cattle. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7587730.bard.

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The overall objective of the current proposal is to develop procedures to improve the pregnancy rate achieved following transfer of fresh or cryopreserved embryos produced in the laboratory into heat-stress recipients. The overall hypothesis is that pregnancy rate in heat-stressed lactating cows can be improved by use of embryo transfer and that additional gains in pregnancy rate can be achieved through development of procedures to cryopreserve embryos, select embryos most likely to establish and maintain pregnancy after transfer, and to enhance embryo competence for post-transfer survival thr
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