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Dissertations / Theses on the topic 'Desmosine'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Hopkins, Gemma V. "The mechanism of desmosome internalisation." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493936.

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Desmosomes are intercellular adhesive junctions providing architectural integrity to tissues that are subject to mechanical stress. During wound healing downregulation of desmosomal adhesion is necessary to facilitate tissue remodeling. Ultrastructural observations suggest that downregulation may occur by internalisation of whole desmosomes but the mechanism of downregulation is not understood. Protein kinase C alpha (PKCα) has been shown to colocalise with desmosomes at the wound edge and to modulate their adhesion. This thesis investigates the internalisation of desmosomes with particular re

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2

Tan, Celia I. C. "A radiological and biochemical perspective on ageing and degeneration of the human thoracic intervertebral disc." University of Western Australia. School of Surgery and Pathology, 2004. http://theses.library.uwa.edu.au/adt-WU2004.0059.

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Disc degenerative changes are directly or indirectly associated with spinal pain and disability. Literature revealed a high prevalence of disc degeneration in the thoracic region, however thoracic MRI degeneration trends and information on disc biochemical matrix constituents are limited for thoracic discs compared to lumbar and cervical discs. The objective of this thesis was to use MRI to investigate the prevalence of disc degenerative changes affecting the human thoracic spine, and to determine the factors affecting spinal disc biochemical matrix. A 3-point subjective MRI grading scale was

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3

Winfield, Kaye R. "Extraction of desmosines from urine : an indicator for inflammatory lung damage." University of Western Australia. School of Paediatrics and Child Health, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0059.

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[Truncated abstract] Urinary desmosines have been proposed as a biomarker for inflammatory lung damage. Desmosine, a breakdown product of elastin, is an effective marker of the degradation of elastin and has been studied in many disease scenarios where there is acute and chronic lung inflammation. Lung matrix degradation has been proven in vitro and in vivo with many experiments showing that the excess proteases degrades lung matrix. The secretion of proteases by neutrophils is an innate response of the body to the invasion by micro organisms and when secreted in excess, the protective anti-pr

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4

Winfield, Kaye R. "Extraction of desmosines from urine : an indicator for inflammatory lung damage /." Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0059.

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5

Lloyd, Susan. "Calcium-independent desmosome adhesion : aquisition, maintenance and modulation." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295856.

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6

Measures, H. R. "A study of desmosome formation in kidney epithelial cells." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234435.

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7

Cabral, Rita Meira e. Cruz de Vasconcelos. "The role of desmoplakin and plakoglobin in desmosome associated disease." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/2413.

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Desmosomes are intercellular junctions that connect intermediate filaments (IFs) of adjacent cells within tissues, generating a large and mechanically resilient network. Desmosomes are prominent in epithelia and the myocardium. Their importance for maintenance of the strength and flexibility of these tissues is underlined by mutations in desmosomal genes which compromise skin or heart and in some instances both. This thesis is focused on two obligate plaque proteins of the desmosome, desmoplakin (DP) and plakoglobin (PG), and their role in disease of skin and heart. A novel homozygous nonsense

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8

ZORILA, FLORESCU SILVANA MARIA. "Alteration du profil d'expression des composants desmosomaux et des jonctions adherentes dans les carcinomes epidermoides de l'oropharynx et leur valeur predictive : etude in vivo et in vitro." Paris 7, 2001. http://www.theses.fr/2001PA07GA02.

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9

DEPONDT, JOEL. "Evaluation prospective des cytokeratines et des composants desmosomaux comme marqueurs diagnostiques et pronostiques des carcinomees epidermoides de l'oropharynx." Paris 7, 2000. http://www.theses.fr/2000PA07GA01.

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10

Asimaki, Angeliki. "Arrhythmogenic right ventricular cardiomyopathy, a disease of the desmosome : genetic and functional studies." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1443947/.

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Mutation analysis of the recognized ARVC genes and of further candidate genes was performed on a large cohort of ARVC patients. Several novel mutations were identified and three further desmosomal genes were linked to the disease: plakophilin2, desmocollin2 and desmoglein2. Heart and skin samples from ARVC patients were subjected to microscopic examination and immunohistochemistry to study the effect of the newly-identified mutations on the structure of cell adhesion complexes.;The functional effects of a particular novel mutation were thoroughly examined in vitro. S39_K40insS is the first dom

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11

Parker, Andrew E. "A molecular analysis of desmosomal glycoproteins II and III : constituents of the desmosome." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303573.

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12

Bharathan, Navaneetha Krishnan. "USING THE FROG EPIDERMIS TO UNCOVER DESMOSOME FUNCTION AND REGULATION IN THE DEVELOPING EMBRYO." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5313.

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The desmosome is one of the major cell adhesion junctions found in the epithelia, heart, and hair follicle. Described as a “rivet” that hold cells together, it provides these tissues with the integrity to withstand the tremendous forces they face in everyday life. Defects in this junction can lead to devastating diseases where patients are susceptible to skin infections and cardiovascular defects. Limited treatments exist for diseases of the desmosome, and strategies do not target all symptoms. Therefore, delineating the function and regulation of desmosomes is of paramount importance for the

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13

Völlner, Frauke [Verfasser], Anna [Gutachter] Starzinski-Powitz, and Ritva [Gutachter] Tikkanen. "Flotillins as novel regulators of desmosome dynamics / Frauke Völlner ; Gutachter: Anna Starzinski-Powitz, Ritva Tikkanen." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2017. http://d-nb.info/1138276944/34.

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14

Cooper, Nichola. "The role of Protein Kinase Cα in the skin and cutaneous wound healing". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-protein-kinase-c-alpha-in-the-skin-and-cutaneous-wound-healing(b0dc19c1-6bd6-4662-adca-010c9f19d785).html.

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Chronic wounds represent a severe socio-economic burden and a key area of unmet clinical need. PKCα is ubiquitous in the skin, particularly the epidermis and functions in numerous pathways that are fundamental to wound repair. By utilising a global PKCα-/- mouse we have identified PKCα-regulated processes both in unwounded skin and during wound healing. PKCα-/- mice display considerably delayed wound healing with a dramatic reduction in re-epithelialisation. By analysing the ultrastructure of the epidermis, I have shown that this delay directly correlates with a failure of wound edge desmosome

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15

AMAR, LAURENCE. "Role de la proteine kinase c dans la regulation des desmosomes au niveau des cellules epitheliales. Etude in vitro sur les keratinocytes de rat foetal et la lignee hela, derivant d'un adenocarcinome cervical humain." Paris 7, 1999. http://www.theses.fr/1999PA07GA03.

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16

Cozzani, Emanuele. "Immunopathologie des pemphigus auto-immuns : caractérisation immunochimiques des antigènes desmosomiaux et implication dans le diagnostic sérologique." Lyon 1, 1997. http://www.theses.fr/1997LYO1T329.

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17

Andersen, Nicholas John. "Characterization of mammalian exocyst subunit Sec3." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/327.

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The Exocyst is a hetero-octameric complex involved in tethering of post-Golgi vesicle transport to sites of membrane expansion. In budding yeast, the Exocyst targets vesicles to bud site resulting in bud emergence and abscission of the daughter cell. Mammalian Exocyst is recruited to developing lateral membranes after cadherin mediated adhesion and then is segregated to adherens junctional complexes (AJC). In polarized epithelia, the Exocyst is required for basal-lateral transport of LDL receptor. Additional Exocyst subunit localizations and functions have been identified. It is not known whet

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18

GRIBBINS, KEVIN MICHAEL. "THE CYTOLOGY OF SPERMATOGENESIS AND ULTRASTRUCTURE OF THE SEMINIFEROUS EPITHELIUM IN REPTILES." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1053715753.

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19

Mouquet, Hugo. "LE ROLE DE L'AUTOANTIGENE DANS LES MALADIES AUTO-IMMUNES : ETUDE DE LA DESMOGLEINE 1 AU COURS DES PEMPHIGUS." Phd thesis, Université de Rouen, 2006. http://tel.archives-ouvertes.fr/tel-00130209.

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Les pemphigus sont des maladies auto-immunes spécifiques d'organe qui affectent la peau et les muqueuses. Ils sont caractérisés par la production d'autoanticorps pathogènes dirigés contre des protéines du desmosome, plus particulièrement, les desmogléines qui permettent l'adhésion entre eux des kératinocytes de l'épiderme. Au cours des pemphigus superficiels (PS), la réponse auto-immune est dirigée contre la desmogléine 1 (Dsg1). Chez les malades atteints de PS, des lymphocytes T autoréactifs vis à vis de la Dsg1 sont présents et interviennent dans la production d'autoanticorps anti-Dsg1. Cet

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20

Bush, David Roy. "The LC/MS/MS Analysis of Pyridinoline and Desmosines in Hypertensive Mouse Aorta, Elucidation of Arginine and Proline Fragmentation for the Analysis of Arginine Metabolism in Mosquitoes by LC/MS/MS, and Mudpit Identification of B. Pseudomallei Proteins in Urine." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/293615.

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This dissertation presents an investigation into the application of mass spectrometry to the detection and quantitation of proteins and amino acids in complex biological samples. This is accomplished by two dimensional chromatography (strong cation exchange / reverse phase) coupled to tandem mass spectrometry followed by peptide spectrum matching for the detection of Burkholderia pseudomallei proteins in infected patient urine samples and reverse phase liquid chromatography coupled to a triple quadrupole and quadrupole time of flight mass spectrometers for the quantitation of cross-linked or

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21

Dedeić, Zinaida. "Investigating the role of iASPP in cutaneous disorders." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:9d393f2d-1e85-46fe-a751-427a0faa23f4.

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Desmosomes are intercellular junctions that anchor intermediate filaments to the sites of intercellular contacts. They are critical for maintaining the integrity of tissues that experience constant mechanical and structural stresses, like the skin and heart. Perturbation of desmosomal adhesion can lead to devastating epidermal and myocardial diseases. However, little is known about the regulators of desmosomes and the role of desmosomes in cell signalling events. Recent work has suggested that iASPP, an inhibitor of the p53 family of proteins, localises at the intercalated discs where desmosom

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22

Yu, Chen-Han, and 余承翰. "Investigations on Desmosome Related Genes in Taiwanese Patients with Arrhythmogenic Right Ventricular Dysplasia." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/58214392455622938019.

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碩士<br>臺灣大學<br>藥理學研究所<br>95<br>Background: Arrhythmogenic right ventricular dysplasia (ARVD) is an inherited disorder of cardiac tissue that often occurs in people during the prime of life before 40 years old. There are four desmosome-related genes: DSP, PKP2, DSG2, and DSC2, which encode for four uniform desmosomal proteins: desmoplakin, plakophilin-2, desmoglein-2, and desmocollin-2. If a mutation of the above genes occurs, the normal function of desmosome may be impaired and results in the occurrence of arrhythmogenic right ventricular dysplasia. To date, a few mutations have been described

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23

Kuo, Yu-Ting, and 郭育廷. "Functional roles of KRT6-KRT14 fusion variant 9 in desmosome remodeling and cell spreading/migration." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/49yg2x.

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碩士<br>國立中山大學<br>生物醫學研究所<br>106<br>Keratins are cytoskeleton proteins with major functions in controlling/maintaining cell morphology and stiffness. Recent studies indicated possible involvement of keratin filaments in cancer developments. In our previous study, we have identified the existence of keratin fusions between KRT6 and KRT14 genes in oral squamous cell carcinoma (OSCC), and patients with the history of chewing betel nut showed higher frequency to harbor such fusions in their tumor tissues. In this study, we studied bio-functional roles of a major keratin fusion isotype K6-K14/V9, whi

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24

Barahona-Dussault, Catherine. "Rôle du test génétique dans la cardiomyopathie arythmogène du ventricule droit. Étude sur une cohorte prospective unicentrique." Thèse, 2008. http://hdl.handle.net/1866/2789.

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La cardiomyopathie/dysplasie arythmogène du ventricule droit (ARVC/D) est un désordre d’origine génétique caractérisé par le remplacement du myocarde par du tissus fibro-adipeux dans le ventricule droit. Ce désordre est responsable d’un grand pourcentage de mort subite, spécialement chez les plus jeunes. ARVC/D est difficile à diagnostiquer avec les outils cliniques actuels. Elle est causée en grande majorité par des mutations dans les protéines desmosomales. ARVC/D a donc des implications d’une grande importance chez les membres de la famille, qui peuvent sans le savoir, être aussi à risque d

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25

Sumigray, Kaelyn D. "Novel Roles for Desmosomes in Cytoskeletal Organization." Diss., 2011. http://hdl.handle.net/10161/5009.

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<p>Microtubules often adopt non-centrosomal arrays in differentiated tissues, where they are important for providing structure to the cell and maintaining polarity. Although the formation and organization of centrosomal arrays has been well-characterized, little is known about how microtubules form non-centrosomal arrays.</p><p>In the mouse epidermis, centrosomes in differentiated cells lose their microtubule-anchoring ability through the loss of proteins from the centrosome. Instead, microtubules are organized around the cell cortex. The cell-cell adhesion protein desmoplakin is required for

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26

Zhang, Kehan. "Mechanotransduction through cytoskeleton and junctions in cardiomyopathies." Thesis, 2020. https://hdl.handle.net/2144/41029.

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Cardiomyopathies represent a heterogeneous group of diseases of the heart muscle that often lead to progressive heart failure with high morbidity and mortality. In a significant and increasing percentage of the patient population, cardiomyopathies have been associated with hereditary mutations in genes encoding critical cellular components that make up the cytoarchitecture of cardiac muscle cells, or cardiomyocytes. While specific mutations have been linked to different classes of cardiomyopathies, it is however not well understood how these mutations cause cytostructural abnormalities that ul

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27

Lee, DonChing, and 李東慶. "Identification and Characterization of Proteins Interacting with Pinin, A Moonlighting Protein Located Both at the Desmosome and within the Nucleus." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/23211914414592074843.

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