Academic literature on the topic 'Destruction of cancer cells'

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Journal articles on the topic "Destruction of cancer cells"

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Harada, Takeshi, Masahiro Hiasa, Jumpei Teramachi, and Masahiro Abe. "Myeloma–Bone Interaction: A Vicious Cycle via TAK1–PIM2 Signaling." Cancers 13, no. 17 (2021): 4441. http://dx.doi.org/10.3390/cancers13174441.

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Multiple myeloma (MM) has a propensity to develop preferentially in bone and form bone-destructive lesions. MM cells enhance osteoclastogenesis and bone resorption through activation of the RANKL–NF-κB signaling pathway while suppressing bone formation by inhibiting osteoblastogenesis from bone marrow stromal cells (BMSCs) by factors elaborated in the bone marrow and bone in MM, including the soluble Wnt inhibitors DKK-1 and sclerostin, activin A, and TGF-β, resulting in systemic bone destruction with loss of bone. Osteocytes have been drawn attention as multifunctional regulators in bone meta
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Weiss, Leonard. "The hemodynamic destruction of circulating cancer cells." Biorheology 24, no. 2 (1987): 105–15. http://dx.doi.org/10.3233/bir-1987-24204.

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Vacarro, Kyle, Juliet Allen, Asaf Maoz, Sarah Reeves, Aaron Hata, and Kipp Weiskopf. "Abstract 1300: Targeted therapies prime lung cancer cells for macrophage-mediated destruction." Cancer Research 82, no. 12_Supplement (2022): 1300. http://dx.doi.org/10.1158/1538-7445.am2022-1300.

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Abstract The CD47/SIRPa axis is an immune checkpoint that regulates macrophage anti-tumor function. Therapies that block CD47 on cancer cells show promise in clinical trials for solid and hematologic malignancies, particularly when combined with other anticancer agents. However, the best combination strategies for using CD47-blocking therapies remain unknown. In this study, we developed a novel in vitro screening platform to identify drugs that render cancer cells more vulnerable to macrophage attack. We performed an unbiased screen of 800 FDA-approved drugs using primary human macrophages and
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Roodman, G. David. "Biology of Osteoclast Activation in Cancer." Journal of Clinical Oncology 19, no. 15 (2001): 3562–71. http://dx.doi.org/10.1200/jco.2001.19.15.3562.

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ABSTRACT: Bone is a frequent site of cancer metastasis. Bone metastases can result in bone destruction or new bone formation. Bone destruction is mediated by factors produced or induced by tumor cells that stimulate formation and activation of osteoclasts, the normal bone-resorbing cells. Local bone destruction also occurs in patients with osteoblastic metastases and may precede or occur simultaneously with increased bone formation. Several factors, including interleukin (IL)-1, IL-6, receptor activator of NF-kappaB (RANK) ligand, parathyroid hormone-related protein (PTHrP), and macrophage inf
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Hampton, Tracy. "Bacteria Protect Colorectal Cancer Cells From Immune Destruction." JAMA 313, no. 13 (2015): 1305. http://dx.doi.org/10.1001/jama.2015.2854.

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Chonghaile, Tríona Ní. "BH3 mimetics: Weapons of cancer cell destruction." Science Translational Medicine 11, no. 475 (2019): eaaw5311. http://dx.doi.org/10.1126/scitranslmed.aaw5311.

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Visochek, Leonid, Asher Castiel, Leonid Mittelman, et al. "Exclusive destruction of mitotic spindles in human cancer cells." Oncotarget 8, no. 13 (2017): 20813–24. http://dx.doi.org/10.18632/oncotarget.15343.

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Weiss, Leonard. "Deformation-driven destruction of cancer cells in the microvasculature." Clinical & Experimental Metastasis 11, no. 5 (1993): 430–33. http://dx.doi.org/10.1007/bf00132986.

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Qiao, Fangfang, Ryan Gordon, Abhinandan Pattanayak, et al. "Abstract 321: BTE-EN1, a novel acting heterobifunctional compound inhibiting bone destruction by established prostate cancer bone metastasis." Cancer Research 85, no. 8_Supplement_1 (2025): 321. https://doi.org/10.1158/1538-7445.am2025-321.

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Bone destruction by prostate cancer (PCa) metastasis is a major cause of morbidity and mortality. In order to destroy bone, PCa and bone cells stimulate each other in a process that requires their coordinated movement within bone itself. To therapeutically inhibit this process, we synthesized the first-in-class heterobifunctional compound, BTE-EN1. One group is a selective inhibitor of cancer cell motility, discovered by us (Nature Communications 2018). It is chemically coupled to a bisphosphonate group, which binds to bone mineral and enables targeted delivery of the therapeutic to bone-destr
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Singh, S., S. R. Ross, M. Acena, D. A. Rowley, and H. Schreiber. "Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells." Journal of Experimental Medicine 175, no. 1 (1992): 139–46. http://dx.doi.org/10.1084/jem.175.1.139.

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Inoculated immunogenic cancer cells after initial growth are potentially rejected by specific host immunity; however, the outcome of the interaction between host and inoculated cancer cells is a function of multiple factors including the route of inoculation, the number of cells, the density of antigens on the injected cancer cells, and the state of the immune system of the host. In the present study, we have examined a different kind of variable: the stroma that inoculated tumor cells initially reside in. The impetus to examine this factor arises from observations that cancer cells from sever
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Dissertations / Theses on the topic "Destruction of cancer cells"

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Morcrette, Mélissa. "Micro et nanoparticules pour des applications biotechnologiques : fabrication de nanoparticules par copolymère dibloc pour l’imagerie médicale ; destruction de cellules cancéreuses par vibrations magnéto-mécaniques de microparticules magnétiques." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAY052/document.

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Les nanoparticules magnétiques sont de nos jours largement exploitées dans le domaine de la recherche pour le biomédical, pour des applications aussi variées que le diagnostic, la thérapeutique ou plus récemment la théranostique. Les nombreuses méthodes de fabrication mises au point à ce jour permettent l’obtention d’une large gamme de nanoparticules en termes de taille, forme, matériaux et donc propriétés magnétiques. Le procédé de fabrication idéal est celui qui permet la fabrication simple, peu coûteuse et à grande échelle de nanoparticules parfaitement monodisperses. En ce sens, le premier
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Svikolnik, A. "Nanotechnology in medicine." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/62574.

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Dearman, Rebecca Jane. "Antibody-dependent destruction of neoplastic cells by celluar effectors." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276345.

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Allbritton, Nancy L. (Nancy Lynn). "The role of calcium in the destruction of target cells by cytotoxic T cells." Thesis, Massachusetts Institute of Technology, 1987. http://hdl.handle.net/1721.1/29517.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Harvard-MIT Divison of Health Sciences and Technology Program in Medical Engineering and Medical Physics, 1987.<br>Title as it appears in M.I.T. Graduate List, June 1987: The role of calcium in the destruction of target cells by cytotoxic T lymphocytes.<br>Bibliography: leaves 224-239.<br>by Nancy L. Allbritton.<br>Ph.D.
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Coulson-Gilmer, Camilla Lucette. "Cancer stem cells and chemoresistance in ovarian cancer." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/18470/.

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The high mortality rate associated with epithelial ovarian cancer (EOC) is due to its insidious onset, leading to late diagnosis as well as eventual development of chemoresistance in the majority of patients. Cancer stem-like cells (CSCs) are thought to contribute to development of multi-drug resistant (MDR) tumours partly through their high level of ABC-transporter expression, which enables them to survive chemotherapy. ABC-transporter (MRP1, MRP2, BCRP, Pgp) and putative CSC-marker (ALDH1A1, CD44) expression was therefore evaluated by immunohistochemistry in a paraffin-embedded cohort of 57
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Griffiths, Helen L. "The role of Fc#gamma#RI in the immune destruction of blood cells." Thesis, University of the West of England, Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244308.

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Sherwood, Benedict T. "Radiosensitivity in bladder cancer cells." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/29874.

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Potentially curative treatment options for patients with organ-confined transitional cell carcinoma (TCC) of the bladder (T1-4a/N0/M0) are radical cystectomy or radiotherapy (RT)-based 'bladder-preserving' regimens. A substantial number of patients who receive RT fail to respond (approximately 50%). Consequently, a greater understanding of the mechanisms of radioresistence is required, together with predictive information regarding the response of tumours to RT. Hypoxia and intrinsic cellular Radiosensitivity (IRS) are examined here, a factors that may influence the outcome of RT.;An immunohis
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Chan, Ching Wan. "Apoptosis in breast cancer cells." Thesis, University of Bristol, 2004. http://hdl.handle.net/1983/8971525c-0de9-4e21-9677-ab73d61ae65c.

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Dai, Prè Elena <1990&gt. "ELECTRICAL CHARACTERIZATION OF CANCER CELLS." Master's Degree Thesis, Università Ca' Foscari Venezia, 2015. http://hdl.handle.net/10579/6321.

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In this work, the impedance of different cancer cell lines was measured using a lab-on-chip device developed by imec (interuniversity electronics center) in Leuven, Belgium. The motivation of this thesis is the detection of circulating tumour cells (CTCs) from cancer metastatic patients. Currently CTC detection is challenging because of the low abundance and phenotype similarity with white blood cells. Imec is developing a proprietary transistor-embedded device for massively parallel on-chip single cell characterization in the European project MIRACLE (Magnetic Isolation and moleculaR Analysi
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Hardyman, Wendy. "Trajectories of value : an exploration of value co-creation and destruction in cancer services." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/104647/.

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This is the first study to apply an analytical framework based on service-dominant logic (S-D logic) to a UK specialist health care context. The primary aim is to investigate how value, when framed as value that is perceived and determined on the basis of use (i.e. ‘value-in-use’, Vargo and Lusch 2004a) is conceptualised by service users (patients) and service providers (health care staff) in a specialist cancer service setting. Factors influencing the trajectories of ‘value’ (creation and destruction) in micro-level health service encounters are also analysed. This work is transdisciplinary i
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Books on the topic "Destruction of cancer cells"

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Farrar, William L., ed. Cancer Stem Cells. Cambridge University Press, 2009. http://dx.doi.org/10.1017/cbo9780511605536.

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Yu, John S., ed. Cancer Stem Cells. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-280-9.

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Rajasekhar, Vinagolu K., ed. Cancer Stem Cells. John Wiley & Sons, 2014. http://dx.doi.org/10.1002/9781118356203.

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Wiestler, O. D., B. Haendler, and D. Mumberg, eds. Cancer Stem Cells. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-70853-7.

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Papaccio, Gianpaolo, and Vincenzo Desiderio, eds. Cancer Stem Cells. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7401-6.

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Bapat, Sharmila, ed. Cancer Stem Cells. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470391594.

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Pat, Moyer Mary, and Poste George, eds. Colon cancer cells. Academic Press, 1990.

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Papaccio, Federica, and Gianpaolo Papaccio, eds. Cancer Stem Cells. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3730-2.

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Sharmila, Bapat, ed. Cancer stem cells. John Wiley & Sons, 2008.

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L, Farrar William, ed. Cancer stem cells. Cambridge University Press, 2009.

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Book chapters on the topic "Destruction of cancer cells"

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Ayyildiz, Orhan, and Yusuf Hekimoglu. "What Is Immunotherapy and History of Immunotherapy in Cancers." In Immunotherapy in Human Cancers. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359388.1.

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Immunotherapy, a transformative cancer treatment, harnesses the immune system’s inherent ability to combat neoplastic cells. Ancient medicine hinted at immunological principles, recognizing natural disease resistance and the body’s defensive capabilities. Over time, the understanding of the immune system evolved, with key contributions from early thinkers like Ibn Sina and later scientific pioneers like Ilya Mechnikov. The immune system, comprising innate and adaptive components, is vital in defending against pathogens and regulating cell proliferation, including cancerous cells. The concept o
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Weiss, Leonard. "The Rapid Destruction of Cancer Cells in the Microvasculature." In New Concepts in Cancer. Macmillan Education UK, 1990. http://dx.doi.org/10.1007/978-1-349-10671-4_5.

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Nayar, Rajiv, and Isaiah J. Fidler. "Role of Macrophages in Recognition and Destruction of Metastatic Cells." In Fundamental Aspects of Cancer. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-1089-8_14.

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Toyokuni, Shinya, Yuki Maeda, Qinying Lyu, Danyang Mi, and Yingyi Kong. "Extracellular Fine Fiber-Induced Carcinogenesis and Its Prevention." In Extracellular Fine Particles. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-7067-0_1.

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Sahip Yesiralioglu, Birsen, Sehmus Ertop, Muzeyyen Aslaner Ak, and Hatice Ayag. "Types of Immunotherapy, Mechanism of Action and Side Effects." In Immunotherapy in Human Cancers. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359388.2.

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Immunotherapy has emerged as a ground breaking approach in the treatment of various cancers and autoimmune diseases, utilizing the body’s immune system to combat disease. This article reviews the mechanisms of action of different types of immunotherapy, including checkpoint inhibitors, monoclonal antibodies, and adaptive cell transfer. Checkpoint inhibitors such as PD-1/PD-L1 and CTLA-4 blockers enhance immune responses by releasing brakes on T cells, thereby promoting anti-tumor immunity. Monoclonal antibodies target specific antigens on cancer cells or immune cells, facilitating targeted des
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Fidler, I. J. "The Recognition and Destruction of Metastatic Cells by Tumoricidal Macrophages." In Biochemistry and Molecular Genetics of Cancer Metastasis. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2299-3_16.

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Somers, Scott D., William J. Johnson, and Dolph O. Adams. "Destruction of Tumor Cells by Macrophages: Mechanisms of Recognition and Lysis and Their Regulation." In Cancer Immunology: Innovative Approaches to Therapy. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2629-8_3.

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Weiss, Leonard. "The Biomechanics of Cancer Cell Traffic, Arrest, and Intravascular Destruction." In Microcirculation in Cancer Metastasis. CRC Press, 2024. https://doi.org/10.1201/9781003574682-9.

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Alver, Kadir Han. "Radiologic Imaging of Scalp Lesions." In The Radiology of Cancer. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359364.1.

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Scalp lesions present significant diagnostic challenges due to their similar appearances, making accurate radiological assessment crucial in lowering mortality and morbidity rates. Understanding the scalp&amp;#39;s anatomy, which includes five distinct layers-skin, dense connective tissue, epicranial aponeurosis, loose connective tissue, and pericranium-enables precise lesion localization. The vast majority of scalp abnormalities (93–98%) are benign, with trichilemmal cysts being the most common, followed by epidermal and dermal cysts, lipomas, nevi, and sebaceous cysts. Although less frequent
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Mravec, Boris. "Avoiding Immune Destruction." In Neurobiology of Cancer. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-68590-3_12.

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Conference papers on the topic "Destruction of cancer cells"

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Smith, David J., Sean J. Josephson, and John C. Bischof. "A Model of Cryosurgical Destruction in AT-1 Prostate Tumor Based on Cellular Damage Mechanisms." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-1326.

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Abstract The thermal history during a prostate cryosurgery is known to lead to different cooling rates, end-temperatures and end-times within a cryosurgical iceball. The tissue exposed to this range of thermal histories will experience thermally-induced biophysical events which affect cell viability (dehydration and intracellular ice formation. IIF), injury due solely to the temperature and time of exposure, and injury due to host response. In this study, the dehydration and IIF behavior of single AT-1 prostate cancer cells is experimentally measured, the biophysical parameters of water transp
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Walsh, Alex J. "Autofluorescence lifetime imaging to identify cancer stem cells from bulk cancer cells." In Multiphoton Microscopy in the Biomedical Sciences XXV, edited by Ammasi Periasamy, Peter T. So, and Karsten König. SPIE, 2025. https://doi.org/10.1117/12.3046370.

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Morcrette, M., H. Joisten, G. Ortiz, et al. "Magnetic superparamagnetic-like microparticles for cancer cells destruction." In 2015 IEEE International Magnetics Conference (INTERMAG). IEEE, 2015. http://dx.doi.org/10.1109/intmag.2015.7156712.

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McLaughlan, James, Sevan Harput, David Cowell, and Steven Freear. "Molecular-targeted nanorods for the localised destruction of cancer cells." In 2014 IEEE International Ultrasonics Symposium (IUS). IEEE, 2014. http://dx.doi.org/10.1109/ultsym.2014.0260.

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Foth, Hans-Jochen. "Threshold for PDT induced cell destruction measured in human cancer cells embedded in the Hen's Egg Model." In Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, edited by John C. Armitage. SPIE, 2017. http://dx.doi.org/10.1117/12.2283885.

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Hapuarachchige, Sudath, Yoshinori Kato, and Dmitri Artemov. "Abstract 727: Specific destruction of iron oxide labeled cancer cells by variable gradient magnetic field." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-727.

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Chiriac, Horia, Anca Emanuela Minuti, Cristina Stavila, and Nicoleta Lupu. "Fe-Cr-Nb-B Magnetic Particles for Cancer Cell Destruction." In 2024 IEEE International Magnetic Conference - Short Papers (INTERMAG Short Papers). IEEE, 2024. http://dx.doi.org/10.1109/intermagshortpapers61879.2024.10577012.

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Layton, Elivia, Feifan Zhou, Wei R. Chen, et al. "Effects of low- and high-dose laser irradiation on destruction and migration of metastatic cancer cells." In Biophotonics and Immune Responses XIII, edited by Wei R. Chen. SPIE, 2018. http://dx.doi.org/10.1117/12.2290654.

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Laug, Walter E. "HETEROGENOUS EXPRESSION OF PLASMINOGEN ACTIVATOR (PA) GENES IN THE HUMAN SARCOMA CELL LINE HT1080." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644395.

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Tumor cell derived PA activities are of crucial importance for tissue invasion and destruction by tumor cells. Therefore, we studied the expression of the PA genes in HT1080 cells using immunoenzymatic methods and specific PA gene probes.Immunenzymatic methods allowed only for the detection of urokinase like PA (u-PA) activities in HT1080 cells which was suppressed by treatment of the cells with dexamethasone (10-7 m). Despite the lack of u-PA activities, the cells still degraded extracellular tissue glycoproteins. Northern blot analysis with specific PA gene probe showed that HT1080 cells exp
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Chiu, Emily, Ivy R. Johnson, Jeffrey S. Miller, Martin Felices, and Deepali Sachdev. "Abstract P5-04-11: Targeting hormone receptor positive breast cancer for immune destruction by natural killer cells." In Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.sabcs19-p5-04-11.

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Reports on the topic "Destruction of cancer cells"

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Markovic, Dubravka, and Edward P. Cohen. Treatment of Breast Cancer with Immunogenic Cells Transfected with DNA from Breast Cancer Cells. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada396744.

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Doxsey, Stephen. Midbody Accumulation in Breast Cancer Cells. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada516482.

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Lagasse, Eric. Ovarian Cancer, Stem Cells, and Bioreactors. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada517343.

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Lau, Lester F. Growth Suppressors of Breast Cancer Cells. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada392204.

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Lau, Lester. Growth Suppressors of Breast Cancer Cells. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada382887.

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Weiss, Ron, and Liliana Wroblewska. An RNAi-enhanced Logic Circuit for Cancer Specific Detection and Destruction. Defense Technical Information Center, 2010. http://dx.doi.org/10.21236/ada542442.

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Weiss, Ron, Liliana Wroblewska, and Zhen Xie. An RNAi-Enhanced Logic Circuit for Cancer Specific Detection and Destruction. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada567986.

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Weiss, Ron, Liliana Wroblewska, and Zhen Xie. An RNAi-Enhanced Logic Circuit for Cancer Specific Detection and Destruction. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada582947.

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Weiss, Ron. An RNAi-Enhanced Logic Circuit for Cancer-Specific Detection and Destruction. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada553119.

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Gonzalez-Perez, Ruben R. Targeting Breast Cancer Stem Cells In Triple Negative Breast Cancer. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada613188.

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