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Journal articles on the topic 'Destructive necrotic pancreatitis'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Kaliev, A. A. "Clinical and morphologic comparison of pancreatic damage in acute destructive pancreatitis." Kazan medical journal 94, no. 4 (2013): 464–68. http://dx.doi.org/10.17816/kmj1950.

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Aim. To compare structural changes revealed at autopsy with clinical data, allowing to clinically predict the pancreatic damage in patients with acute destructive pancreatitis. Methods. Case histories and post-mortem pancreatic tissue samples from 12 patients who died of acute destructive pancreatitis, were examined. Results. Autopsies revealed the similar frequency of pancreatic anterior and posterior surface damage. Three types of pancreatic damage were observed: (1) total or extensive necrosis - 5 cases; (2) pancreatic fatty degeneration - 3 cases; (3) inflammatory changes with local necrot

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2

Mishchenko, V. V., V. V. Hrubnyk, P. I. Pustovoyt, V. V. Horyachyy, V. V. Velychko, and R. Yu Vododyuk. "Diagnosis and treatment of destructive forms of acute pancreatitis." Modern medical technologies 41 part 1, no. 2 (2019): 65–70. http://dx.doi.org/10.34287/mmt.2(41).2019.13.

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Purpose of the study. The study of the diagnosis and treatment of destructive forms of acute pancreatitis and the identification of possible ways to optimize them. Materials and methods. Destructive forms of acute pancreatitis were found in 16,8%. The algorithm for treating acute destructive pancreatitis consisted in artificial ventilation of the lungs, adequate infusion therapy, peridural anesthesia, setting up a nasoenteric probe, stimulating the bowels, correcting hemodynamics, intra- and extracorporal detoxification, antisecretory, anti-bacterial, hepatoprotective, cerebroprotective, antio

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3

Koshevsky, P., S. Alekseyev, O. Popkov, V. Ginyuk, and N. Bovtiuk. "PANCREATOGENIC MORPHOSTRUCTURAL CHANGES IN THE HEART, LUNGS AND OTHER TARGET ORGANS IN DESTRUCTIVE PANCREATITIS." Emergency Cardiology and Cardiovascular Risks 5, no. 1 (2021): 1217–22. http://dx.doi.org/10.51922/2616-633x.2021.5.2.1217.

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Introduction. Pathomorphological changes in destructive pancreatitis develop both in the pancreas and in various organs and tissues, it determining the clinical course and outcome of the disease. Most often in destructive pancreatitis, the cardiopulmonary system is affected, as well as the liver, kidneys, and brain. Damage to these target organs is one of the main elements of pathogenesis and thanatogenesis in destructive pancreatitis and is of interest not only for surgeons, but also for other clinical specialists, including cardiologists. Aim. To conduct a retrospective analysis of the most

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4

Imayeva, Al'fiya K., and Tagir I. Mustafin. "AUTOPSY FEATURES AT THE ACUTE DESTRUCTIVE PANCREATITIS." Morphological newsletter 28, no. 2 (2020): 48–54. http://dx.doi.org/10.20340/mv-mn.2020.28(2):48-54.

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In all variants of the destructive form of pancreatitis, the involvement of adipose tissue of both para-pancreatic and distant localization was noted. In this case, it is necessary to improve the pathological diagnosis of acute destructive pancreatitis. The aim of the study was to develop new techniques for postmortem examination of those who died from complications of acute pancreatitis. Pathological studies were supplemented by the methods proposed by the authors, which made it possible to clarify the spread of the infectious agent through the retroperitoneal tissue. The scheme proposed by t

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Mishchenko, V. V., P. I. Pustovoit, R. Yu Vododyuk, V. V. Velichko, and V. V. Goryachy. "ARROSIVE BLEEDING WITH PANCREATIC NECROSIS — TACTICAL APPROACHES." Kharkiv Surgical School, no. 1 (February 20, 2020): 85–88. http://dx.doi.org/10.37699/2308-7005.1.2020.12.

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Summary. The problem of hemorrhagic complications of destructive pancreatitis is relevant. The aim of the study was to study the frequency and sources of hemorrhagic complications in patients with pancreatic necrosis, to evaluate the tactics of diagnosis and the effectiveness of methods to stop bleeding. Materials and methods. A study of the results of treatment of 40 patients with acute necrotizing pancreatitis was conducted. Results and its discussion. In 67.5 % of patients with acute necrotizing pancreatitis, hemorrhagic complications in the form of arrosive bleeding were

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Tsoi, O., K. Mamakeev, S. Kozhakhmetov, K. Rustemova, Zh Telmanova, and Zh Zhalgasbaev. "Ulinastatitis in Complex Treatment of Acute Pancreatitis (Literature Review)." Bulletin of Science and Practice 10, no. 5 (2024): 313–27. http://dx.doi.org/10.33619/2414-2948/102/40.

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The purpose of this literature review is to assess the completeness and significance of recent research on the treatment of a destructive form of pancreatitis for public health and scientific achievements, highlighting areas that require further detailed study. A review of foreign literature on the use of the protease inhibitor ulinastatin in the complex conservative treatment and prevention of acute pancreatitis is made. The clinical and laboratory effectiveness of the drug in preventing the transition of uninfected pancreatic necrosis into a complicated purulent-necrotic form with the develo

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S., Kozhakhmetov, Rustemova K., Tsoi O., et al. "Hepatic Failure in Pancreonecrosis and the Development of Abdominal Sepsis." Bulletin of Science and Practice 10, no. 11 (2024): 181–95. http://dx.doi.org/10.33619/2414-2948/108/24.

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It is well known that acute destructive pancreatitis, pancreonecrosis is accompanied by severe endogenous intoxication, often leading to the development of multiple organ failure syndrome, liver failure is one of the important links in this process. The mortality rate of patients with pancreonecrosis related to liver failure is as high as 83%, and approximately 5% of patients with pancreonecrosis have fulminant liver failure. Proven: liver function is closely related to the progression of purulent-necrotic complications in patients with acute destructive pancreonecrosis. The authors present th

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Chudnykh, S. M., Yu V. Kulezneva, D. A. Mamonov, O. V. Moroz, and V. S. Egorov. "Combined minimally invasive procedures for purulo-necrotic complications of destructive pancreatitis." Endoskopicheskaya khirurgiya 21, no. 1 (2015): 13. http://dx.doi.org/10.17116/endoskop201521113-19.

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9

Sokolov, Manol, Tsvetan Popov, Svilen Maslyankov, et al. "Vacuum-assisted laparostomy for peritonitis-complicated destructive pancreatitis." Surgery 86, no. 2 (2022): 65–74. https://doi.org/10.5281/zenodo.15266714.

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INTRODUCTION. Infection of pancreatic and peripancreatic necrotic tissues and fluid collections occurs in less than 10% of patients with acute pancreatitis. However, it still causes high mortality, ranging from 20% to 40% according to recent reports. A multidisciplinary team (radiologists, gastroenterologists, anesthesiologists-resuscitators) is often involved in the complex management of this severe pathology. In this interdisciplinary context, the concept of "source control" is summarized as a four-step algorithm: elimination of the cause of infection, elimination of the infected substrate,

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Syplyvy, V. A., V. I. Robak, D. V. Ievtushenko, V. O. Kurbatov, S. V. Grinchenko, and L. O. Robak. "EARLY CLINICAL MARKERS OF SEVERITY OF ACUTE NECROTIC PANCREATITIS." Kharkiv Surgical School, no. 2 (April 20, 2020): 53–57. http://dx.doi.org/10.37699/2308-7005.2.2020.11.

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Summary. Acute necrotic pancreatitis carries enough difficulty in diagnosis and treatment. Destructive forms with retroperitoneal tissue damage cause lethality up to 70 %. The aim was to establish early clinical markers of disease severity. Material and methods. The results of surgical treatment of 120 patients with acute pancreatitis were analyzed. Patients were divided into groups: first group – 40 patients without parapancreatitis; second group — 80 patients with parapancreatitis. Peripheral blood reaction, main biochemical indicators, blood electrolytes, general condition by in

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Rodoman, G. V., T. I. Shalaeva, and M. I. Aleksandrov. "Methods of extracorporeal detoxification in the treatment of patients with acute necrotic pancreatitis and DIC." Hirurg (Surgeon), no. 7-8 (July 13, 2020): 9–21. http://dx.doi.org/10.33920/med-15-2004-01.

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The article analyzes the results of treatment of patients with acute necrotic pancreatitis and DIC who underwent extracorporeal detoxification (ECD) with heparin anticoagulation. We performed a retrospective analysis of the medical records of such patients who were treated in Moscow Clinical Hospital No. 24 in 2016–2017. Disorders indicating the development of DIC were detected in 38 patients with acute necrotic pancreatitis, 13 of them underwent extracorporeal detoxification methods, in 25 patients ECD was not used. The effect of ECD on hemostasis and clinical outcomes was studied. A tendency

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Imaeva, Alfiya Kamilevna, and Tagir Islamnurovich Mustafin. "Retroperitoneal Tissue Contrast Examination in Different Types of Acute Destructuve Pancreatitis." Journal of Experimental and Clinical Surgery 11, no. 4 (2018): 264–67. http://dx.doi.org/10.18499/2070-478x-2018-11-4-264-267.

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Acute destructive pancreatitis refers to severe surgical pathology with high mortality. Destructive changes in this case cover both adjacent and distant structures. The aim of the study was to achieve a more accurate injection of the liquid contrast agent to the tissues of the retroperitoneal space affected by the purulent-necrotic process. We have developed a method that involves the use of a special device with a metal goniometer with a gradation of up to 180° with clamps to fix the syringe with a needle. Syringe with a needle is fixed in the device at an angle of 40° to 50° depending on the

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Alfiya, Imaeva, Tagir Mustafin, Bazekin Georgiy, Radmir Rakhimov, and Ildar Sharifgaliev. "Simulation of Acute Destructive Pancreatitis with Damage to the Adjacent Adipose Tissue in Pigs." Journal of Experimental and Clinical Surgery 13, no. 3 (2020): 233–40. http://dx.doi.org/10.18499/2070-478x-2020-13-3-233-240.

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The aim of the study was to develop a model of acute destructive pancreatitis with damage to the extra-organ adipose tissue. Materials and methods. Simulation of acute destructive pancreatitis with damage of the extra-organ adipose tissue was performed in 22 white breed boars aged 3 months. The animals were divided into groups in accordance with two series of studies, where the control (first) group included 15 animals with the pancreas and extra-organ adipose tissue remained intact. Acute destructive pancreatitis was simulated in 7 pigs of the experimental (second) group based on the proposed

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Tverdokhlib, I. V., and D. Yu Zinenko. "Ultrastructure of the hemomicrocirculatory bed and parenchymatous-stromal elements of the pancreas and liver in a model of acute pancreatitis using different doses of L-arginin." Morphologia 14, no. 4 (2021): 79–89. http://dx.doi.org/10.26641/1997-9665.2020.4.79-89.

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Background. The development of acute pancreatitis is not limited to isolated damage to the pancreas. After creating models of acute pancreatitis using various substances that enhance the secretion of the gland, have a toxic or local activating effect, the researchers showed their dose-dependent effect. The question of the reaction of the hepatic microcirculation system during the development of acute pancreatitis, as well as their pathogenetic significance in the development of pathomorphological changes in the pancreas and liver in most aspects remains open. Objective. The purpose of the curr

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Duzhyi, I. D., O. L. Sytnik, and V. Ya Pak. "Polymorphism of the proinflammatory and anti–inflammatory cytokines genes in patients with an acute pancreatitis in the Northern–Eastern region of Ukraine." Klinicheskaia khirurgiia 89, no. 11-12 (2022): 10–13. http://dx.doi.org/10.26779/2522-1396.2022.11-12.10.

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Objective.To determine the influence of the genes polymorphism of proinflammatory – interleukin–8 A–251T (rs 4073) and antiinflammatory – interleukin–10 C–592A (rs 1800872) cytokines on course of an acute pancreatitis. Materials and methods. The genes polymorphism of proinflammatory – interleukin–8 A–251T (rs 4073) and antiinflammatory – interleukin–10 C–592A (rs 1800872) cytokines were studied in 83 patients with an acute pancreatitis, using the method of polymerase chain reaction (PCR). The control group have consisted of 60 healthy persons without an acute pancreatitis in anamnesis.&#

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Valeev, A. A. "Assessment of the severity of acute destructive pancreatitis for proper treatment selection." Kazan medical journal 94, no. 5 (2013): 633–36. http://dx.doi.org/10.17816/kmj1906.

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The review covers the most common integrated scales used for the assessment of severity of acute destructive pancreatitis. The use of those scales in the surgical in-patient department is discussed. Different views of Russian and foreign pancreatologists on the use of integrated scales to predict the disease outcome according to various criteria (clinical, laboratory, and special examination methods) are presented. Because of the acute pancreatitis morphological forms variety at admission for urgent surgery, there is a need for a comprehensive assessment of the disease severity in such patient

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Doroshenko, Dmitry A., Olga A. Tseneva, Sergey V. Mikhaylusov, et al. "ANALYSIS OF THE STRUCTURE OF LOCAL COMPLICATIONS TO ACUTE NECROTIC PANCREATITIS USING RADIATION DIAGNOSTICS METHODS." Acta medica Eurasica, no. 4 (December 27, 2023): 44–54. http://dx.doi.org/10.47026/2413-4864-2023-4-44-54.

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The use of multispiral computed tomography and ultrasound examination in pancreatic necrosis makes it possible to determine the shape, volume and localization, to distinguish four types of lesions. The aim of the study was to determine the incidence rate and the structure of local aseptic and purulent complications in acute necrotic pancreatitis using radiation diagnostics methods, to assess complications impact on the course and prognosis of the disease. Materials and methods. 63 patients with pancreatic necrosis who underwent treatment were examined during 2 years. The results of these exami

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Korobka, V. L., R. V. Korobka, and A. M. Shapovalov. "The use and evaluation of prevention methods to reduce inflammatory and diffuse septic complications in patients undergoing pancreatic resection." Almanac of Clinical Medicine 46, no. 6 (2018): 648–59. http://dx.doi.org/10.18786/20720505-2018-46-6-648-659.

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Background:Surgery for chronic pancreatitis and pancreatic neoplasms is associated with a risk of acute destructive pancreatitis and pancreaticojejunal anastomotic leakage in the early postoperative period. Despite the availability of multiple surgical and pharmaceutical approaches to prevent these complications, they continue to be associated with high mortality.Aim:To evaluate the efficacy of the clinical use of our original preventive methods of postoperative pancreatitis and diffuse inflammatory and septic complications in patients undergoing pancreatic resection due to its benign and mali

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Andriuschenko, V. P. "Acute diffused purulent peritonitis: conceptual aspects of the modern surgical tactics." Infusion & Chemotherapy, no. 3.1 (October 11, 2020): 7–8. http://dx.doi.org/10.32902/2663-0338-2020-3.1-03.

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Objective. To accentuate an attention on conceptual aspects of surgical treatment of patients on acute purulent diffused peritonitis (APDP). Materials and methods. Were treated a 371 patients on APDP in age from 18 to 87 years; males – 207 (56 %), females – 164 (44 %). In structure of factors of peritonitis development predominated an acute destructive appendicitis (23 %), perforated ulcer of pyloroduodenal part of the stomach (21 %), acute pancreatitis / purulent-necrotic pancreonecrosis (18 %), acute destructive cholecystitis (14 %). Results and discussion. Carried out analysis a

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Boyko, V. V., V. N. Lykhman, S. V. Tkach, et al. "OPTIMIZATION OF DIAGNOSTICS AND TREATMENT OF DESTRUCTIVE FORMS OF ACUTE PANCREATITIS." Kharkiv Surgical School, no. 1 (February 20, 2020): 98–103. http://dx.doi.org/10.37699/2308-7005.1.2020.15.

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Summary. Objective — increasing the efficiency of diagnosis and treatment in patients with destructive forms of pancreatitis. Materials and methods. 89 patients with acute destructive pancreatitis were examined. There were 37 men (41,5 %), 52 women (58,4 %). The average age of patients ranged from 28 to 64 years. In order to objectively assess the severity of the inflammatory process in the pancreas and surrounding tissues, organs of the abdominal cavity, clinical and biochemical studies were used, as well as high-tech methods such as ultrasound examination with dopplerometry, computed t

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Andriushchenko, V. P., M. M. Tutka, and V. V. Kunovskyi. "Glycemic disorders in acute pancreatitis: significance of microstructural changes of pancreatic parenchyma." Ukrainian Journal of Clinical Surgery 90, no. 1 (2023): 7–12. http://dx.doi.org/10.26779/2786-832x.2023.1.07.

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Objective. To study the character and peculiarities of pathohistological changes of pancreatic tissues on the autopsy material, including its endocrine apparatus in acute necrotic pancreatitis and to determine connection between established changes and occurrence of glycemia. Materials and methods. Pathohistological investigation of 48 preparation of pancreatic gland was performed on the autopsy material in 11 dead patients with an acute necrotic pancreatitis, using method of the light microscopy. Results. There was established the presence of microstructural disorder of pancreatic

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Likhman, V. M., A. A. Merkulov, A. N. Shevchenko, et al. "Diagnostic Criteria for Acute Destructive Pancreatitis." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 2 (2021): 94–100. http://dx.doi.org/10.26693/jmbs06.02.094.

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The relevance of the emergence of innovative technologies, more sophisticated diagnostics methods, opportunities for intensive therapy, antibacterial prophylaxis, surgical methods of treatment involving minimally invasive surgery, does not solve the problem of high overall mortality in severe acute pancreatitis at this time. This indicator for the last ten years remains at a high level (10-30%), and in case of inflammatory forms of severe pancreatitis, reaches 85%. Traditional laboratory criteria for the diagnosis of pancreatic necrosis may involve leukocytosis with the destruction of the leuk

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Lyzikov, A. N., V. M. Mayorov, Z. A. Dundarov, and Yu N. Avizhets. "MORPHOLOGICAL FEATURES OF EXTRAPANCREATIC LESION OF INTERNAL ORGANS IN ACUTE ENZYMATIC PARAPANCREATITIS." Health and Ecology Issues, no. 2 (June 28, 2014): 61–66. http://dx.doi.org/10.51523/2708-6011.2014-11-2-13.

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The article analyzes the causes of fatal outcomes and structure of postoperative complications in patients who died of acute destructive pancreatitis. The analysis of morphological changes of internal organs has shown that the cause of early fatal outcomes is massive enzymatic noncorrected intoxication, and late lethal outcomes are caused by the intoxication associated with resorbtion of toxic substances from necrotically changed parapancreatic cellular tissue. The special attention is given to the features of anatomic interrelation of the destructively changed pancreas and the affected parapa

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Rayimov, G. N., Zh Kholmukhamedov, A. R. Tillaboldiev, Sh Sh Dekhkonov, and Sh Kh Kosimov. "Results of surgical treatment of destructive pancreatitis." BIO Web of Conferences 65 (2023): 05036. http://dx.doi.org/10.1051/bioconf/20236505036.

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Based on a retrospective analysis of the methods of surgical correction of ¬various clinical and morphological forms of pancreatic necrosis, the best options for tactics and surgical techniques for this pathology are proposed.

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Masyukevich, A. I. "PATHOMORPHOLOGICAL CHANGES ASSESSMENT IN EXPERIMENTAL DESTRUCTIVE PANCREATITIS IN RATS." Hepatology and Gastroenterology 8, no. 2 (2024): 138–45. https://doi.org/10.25298/2616-5546-2024-8-2-138-145.

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Background. Acute pancreatitis remains to be a challenge in emergency abdominal surgery. Severe forms of the disease have a number of complications associated with high mortality. There is a need for a thorough study of the pathogenesis of acute pancreatitis and its adequate pathomorphological assessment, first of all, in an experiment for the purpose of testing new therapeutic approaches. Objective. To assess pathomorphological changes in the pancreas and its surrounding tissues in experimental acute destructive pancreatitis (ADP) and to identify 4 categories of changes most specific for dest

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Плеханов, Aleksandr Plekhanov, Решетников, and Denis Reshetnikov. "PORTO-HEPATIC HEMODYNAMICS IN PATIENTS WITH DESTRUCTIVE PANCREATITIS COMBINED WITH LIVER FAILURE." Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук 1, no. 4 (2016): 68–71. http://dx.doi.org/10.12737/22971.

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Extraorgan complications of acute destructive pancreatitis are registered in 60–95% of patients. Liver failure is regis-tered in one of the four patients with pancreatic necrosis. We analyzed the results of surgical treatment of 122patients with acute destructive pancreatitis. We studied clinical indicators of liver failure in 103(84.4%) patients with acute pancreatitis. The development of portal hypertension with decrease in hepatic volume perfusion is an important ele-ment in the pathogenesis of acute pancreatitis and associated liver function abnormalities. In patients with severe and moder

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Kovalska, I., O. Dronov, S. Zemskov, E. Deneka, and M. Zemskova. "Patterns of Pathomorphological Changes in Acute Necrotizing Pancreatitis." International Journal of Inflammation 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/508915.

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Acinar necrosis is the basic microscopic sign of acute necrotizing pancreatitis (ANP). Microcirculation disorder is one of the major factors in the pathogenesis and morphogenesis of ANP besides free radicals and damage of enzymatic origin. This study is dedicated to the description of microscopic changes in the pancreatic stroma in ANP, which leads to destruction of the exocrine pancreas with a putative mechanism of endocrine function preservation. This study has been carried out on histological samples of pancreas from 224 patients with ANP. Histological staining was performed with hematoxyli

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Scully, Kerry A., Shuan C. Li, James C. Hebert, and Thomas D. Trainer. "The Characteristic Appearance of Non-Alcoholic Duct Destructive Chronic Pancreatitis." Archives of Pathology & Laboratory Medicine 124, no. 10 (2000): 1535–38. http://dx.doi.org/10.5858/2000-124-1535-tcaona.

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Abstract We report 2 patients with an unusual form of chronic pancreatitis, both of whom were treated for clinical suspicion of pancreatic malignancy. The surgical specimens revealed a dense lymphoplasmacytic infiltration of the main and interlobular branches of the pancreatic duct, causing sclerosis of the duct wall, diffuse irregular lumenal narrowing, extensive parenchymal fibrosis, and organ enlargement. Neither case showed calcifications, fat necrosis, or cyst formation, features usually seen in alcoholic pancreatitis, nor was there any evidence of neoplasia. One patient had an unusual fo

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Veselyy, S., M. Veselyy, and E. Galinskij. "ACUTE DESTRUCTIVE PANCREATITIS IN CHILDREN." Neonatology, surgery and perinatal medicine 8, no. 1(43) (2023): 31–38. http://dx.doi.org/10.24061/2413-4260.xiii.1.47.2023.5.

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Unlike adults, acute pancreatitis in children is a rare disease. The absence of unified standards for the diagnosis, treatment and rehabilitation of children with acute destructive pancreatitis, as well as high rates of complications and mortality, determined the relevance of our study.Materials and methods. Materials and methods. The results of treatment of 11 children with acute destructive pancreatitis were studied. The age of the patients ranged from 2 to 16 years. Laboratory examination in all patients included general and biochemical analyzes of blood, urine, peritoneal and thoracic exud

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Stepanov, V. A., and O. N. Vetchinnikova. "A rare case of acute destructive pancreatitis in a patient with chronic kidney disease on peritoneal dialysis: diagnostic and treatment challenges." Russian Journal of Transplantology and Artificial Organs 25, no. 4 (2023): 139–49. http://dx.doi.org/10.15825/1995-1191-2023-4-139-149.

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Patients with chronic kidney disease are susceptible to developing acute pancreatitis. We present a rare clinical case of acute pancreatitis with the formation of pancreatic necrosis in a patient on peritoneal dialysis (PD), debuted with PD–associated peritonitis. On hospitalization, there were no diagnostic criteria for acute pancreatitis; treatment for dialysis peritonitis was ineffective. Repeated ultrasound examination revealed signs of diffuse changes in the pancreas and multi-chamber formation of the small pelvis. Refractory peritonitis, inadequate ultrafiltration, and unclear nature of

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Vinnik, Yu S., E. V. Repina, E. V. Serova, et al. "URODYNAMIC ABNORMALITIES IN THE KIDNEYS OF PANCREONECROSIS." Annals of the Russian academy of medical sciences 69, no. 1-2 (2015): 19–21. http://dx.doi.org/10.15690/vramn.v69.i1-2.936.

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This paper presents experience in monitoring renal ultrasound data in patients with pancreatonecrosis from 20 to 60 years. It is also present two clinical cases of renal urodynamics in destructive forms of acute pancreatitis. Edematous form of acute pancreatitis and pancreatic cause violations not only secretion but also excretory function of the nephros. In patients with pancreatic necrosis accompanied by the formation of zones of limited fluid in the retroperitoneal space including retroperitoneal phlegmon may occur ureteral compression which is accompanied by appearance of urodynamic disord

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K., Sydygaliev, Imanov B., Syrgaev D., et al. "Experience of Surgical Treatment of Patients with Acute Necrotizing Pancreatitis." Bulletin of Science and Practice 10, no. 11 (2024): 196–201. http://dx.doi.org/10.33619/2414-2948/108/25.

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Acute pancreatitis occurs as a result of autolysis of pancreatic tissue by lipolytic and activated proteolytic enzymes, which leads to a wide range of changes from edema to focal and extensive necrosis and ranks third in the development of the surgical structure of the abdominal cavity. Destructive forms occur in 30-60% of cases, and mortality fluctuates between 30-85%. The frequency of purulent results reaches 21%. The article presents a technique for the surgical treatment of patients with acute necrotizing pancreatitis.

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Firsova, Tatiana I., Sergey A. Alekhin, Dmitry P. Nazarenko, et al. "Combined anti-mediator therapy for severe destructive forms of acute necrotizing pancreatitis in rats." Research Results in Pharmacology 8, no. (2) (2022): 95–110. https://doi.org/10.3897/rrpharmacology.8.79939.

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Introduction: Inflammatory mediators play a major role in pathogenesis of acute pancreatitis with TNF (tumor necrosis factor) as the most important one. Development of effective combined therapy could help to decrease tissue damage, improve results and, finally, diminish the mortality rate in this severe pathology. Materials and methods: All the studies were performed on 120 female white Wistar rats, weighing 250±25g. Acute pancreatitis reproduced by an intracanalicular injection of bile salts compound. Results and discussion: The data obtained in the course of the study on the pronounced panc

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Podoluzhniy, V. I., V. A. Pelts, and I. A. Radionov. "Statistical characteristics of number and structure of hospitalizations and treatment of patients with acute and chronic pancreatitis in the surgical departments in Kemerovo region." Herald of Pancreatic Club 43, no. 2 (2019): 47–51. http://dx.doi.org/10.33149/vkp.2019.02.07.

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Aim. Determine the number of hospitalizations and treatment of patients with acute (AP) and primary chronic pancreatitis (PCP) in surgical departments No 1 and No 2 of the Regional Clinical Hospital of Emergency Medical Care n. a. M. A. Podgorbunsky (Kemerovo) and surgical departments in Kemerovo region from 1993 to 2017. Methods. A comparative analysis of the number and structure of treatment of patients with AP over two decades was carried out. Number of PCP surgeries in the Regional Hepatology Center after 1995 was comparatively analyzed. Results. There was an increase in number

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Garber, Ari, Catherine Frakes, Zubin Arora, and Prabhleen Chahal. "Mechanisms and Management of Acute Pancreatitis." Gastroenterology Research and Practice 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/6218798.

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Acute pancreatitis represents a disorder characterized by acute necroinflammatory changes of the pancreas and is histologically characterized by acinar cell destruction. Diagnosed clinically with the Revised Atlanta Criteria, and with alcohol and cholelithiasis/choledocholithiasis as the two most prominent antecedents, acute pancreatitis ranks first amongst gastrointestinal diagnoses requiring admission and 21st amongst all diagnoses requiring hospitalization with estimated costs approximating 2.6 billion dollars annually. Complications arising from acute pancreatitis follow a progression from

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36

LUKASHEW, ANDREW D., SERGEY V. KUROCHKIN, MARAT R. TAGIROV, ELVIRA B. ZAKIROVA, and DENIS V. MAKAROV. "INTERNAL PANCREATIC FISTULA IN A PATIENT WITH ACUTE DESTRUCTIVE PANCREATITIS ASSOCIATED WITH SYSTEMIC CONNECTIVE TISSUE DISEASES." Bulletin of Contemporary Clinical Medicine 17, no. 6 (2024): 112–19. https://doi.org/10.20969/vskm.2024.17(6).112-119.

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Introduction. A pPancreatic fistula is an abnormal connection of pancreatic ductal epithelium with another epithelial surface. Pancreatic fistulas may occur as a complication of acute or chronic pancreatitis. The incidence of external and internal fistulas in the outcome of pancreatic necrosis ranges from 5 to 50%. Aim was to present for discussion a clinical case of a female patient with acute pancreatitis complicated by pseudocysts and an internal pancreatic fistula, associated with systemic connective tissue diseases, as well as the results of diagnosing and the treatment options chosen. Ma

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Kotchergin, Vladimir G., Sergey V. Sviridov, Valerii V. Subbotin, and Maria S. Vetsheva. "Trace elements and metalloenzymes in patients with acute pancreatitis." Clinical nutrition and metabolism 2, no. 3 (2021): 141–56. http://dx.doi.org/10.17816/clinutr99881.

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For many decades, acute pancreatitis has occupied third place in the structure of emergency surgical abdominal conditions, second to acute calculous cholecystitis and acute appendicitis. Simultaneously, acute pancreatitis ranks first in mortality among other acute surgical conditions. Often acute pancreatitis occurs under the mask of gastroenterological problems. Complex electrolyte and trace element disorders are often formed in the early stages of developing pancreatitis. The concepts of diagnosis and therapeutic and surgical treatment of acute pancreatitis are formulated and reflected

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Stepchenkov, Roman. "Tactics of emergency care for patients with pancreatic necrosis." Vrač skoroj pomoŝi (Emergency Doctor), no. 6 (June 1, 2020): 33–37. http://dx.doi.org/10.33920/med-02-2006-02.

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Pancreatic necrosis is a destructive lesion of the pancreas, often leading to the development of multiple organ failure. The basis of pathogenesis is a violation of the mechanism of counteraction to proteolytic enzymes produced by the pancreas. Pancreatic necrosis is a formidable complication of pancreatitis, with mortality ranging from 30 to 70%. To date, the frequency of occurrence of this pathology in surgical practice takes second place after acute appendicitis. The leading role in prevention of pancreatic necrosis and the prevention of lethal outcome is played by early detection, timely h

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Darvin, V. V., S. V. Onishchenko, E. V. Loginov, and A. A. Kabanov. "Severe acute pancreatitis: risk factors of adverse outcomes and their correction." Annaly khirurgicheskoy gepatologii = Annals of HPB surgery 23, no. 2 (2018): 76–83. http://dx.doi.org/10.16931/1995-5464.2018276-83.

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Aim. To analyze management of severe acute destructive pancreatitis and to determine the main tactical, anatomical and pathophysiological factors determining risks of adverse outcomes. Material and methods. 3581 patients with acute pancreatitis were enrolled. Retrospectively, 239 patients were assigned to severe pancreatic necrosis; invasive surgical techniques were applied in 210 cases. Twenty-nine patients with pancreatic necrosis underwent endoscopic papillosphincterotomy with main pancreatic duct stenting. Results. Overall mortality in patients with severe pancreatic necrosis was 32.3%, in

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Stepchenkov, Roman Petrovich. "The principles of providing emergency care for patients with pancreatic necrosis." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 7 (July 1, 2021): 59–64. http://dx.doi.org/10.33920/med-10-2107-08.

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At the present stage, the treatment of patients with pancreatic necrosis is one of the most urgent surgical tasks. Pancreatic necrosis is a destructive lesion of the pancreas, often leading to the development of multiple organ failure. The pathogenesis is based on a violation of the mechanism of counteraction to proteolytic enzymes produced by the pancreas. Pancreatic necrosis is a formidable complication of pancreatitis, with mortality ranging from 30 to 70 %. Today, in terms of the frequency of occurrence in surgical practice, this pathology ranks second after acute appendicitis. The leading

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Banerjee, Somya Nath, Ashwin Kumar Azhagarasan, and Vettri Vignesh. "Uncommon Fistulous Complications in Pancreatitis: Rare Radiological Findings." Journal of Neonatal Surgery 14, no. 19S (2025): 405–9. https://doi.org/10.63682/jns.v14i19s.4776.

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Background: Fistulous complications arising from pancreatitis are uncommon but can lead to significant diagnostic and therapeutic challenges. These abnormal communications with adjacent organs result from enzymatic tissue destruction, necrosis, or chronic inflammation. Objective: To present a case series of rare pancreatitis-associated fistulas—choledochogastric, pancreaticocolonic, and pancreaticopleural—and to highlight their diverse radiological findings, diagnostic difficulties and clinical presentations. Methods: Three patients with a history of acute or chronic pancreatitis presented wit

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Su, Song, Tiancheng Liang, Xiang Zhou, Kai He, Bo Li, and Xianming Xia. "Qingyi decoction attenuates severe acute pancreatitis in rats via inhibition of inflammation and protection of the intestinal barrier." Journal of International Medical Research 47, no. 5 (2019): 2215–27. http://dx.doi.org/10.1177/0300060518809289.

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Objective Qingyi decoction (QYD) has beneficial effects in severe acute pancreatitis (SAP). We assessed the therapeutic effect and mechanisms of QYD in SAP. Methods A rat model of SAP was induced by pancreatic ductal injection of sodium taurocholate. QYD was administered intragastrically immediately postoperatively and once every 12 hours. Serum amylase, endotoxin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and D-lactate levels were measured at 12, 24, and 48 hours. Histological changes in the pancreas and ileum were analyzed. Expression of nuclear factor kappa-light-chain-enhancer

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Bazhukhina, I. V., N. V. Klimova, A. A. Gaus, and N. N. Petrova. "The Role of Perfusion Computed Tomography as a Predictor of Pancreatic Necrosis in Acute Pancreatitis." Radiology - Practice, no. 3 (April 20, 2022): 11–23. http://dx.doi.org/10.52560/2713-0118-2022-3-11-23.

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The article analyzes the data obtained as a result of the use of imaging methods in 35 patients with a new coronavirus infection who were treated in the infectious diseases department of the Surgut Regional Clinical Hospital. In the course of treatment in this group of patients, the appearance of symptoms of acute pancreatitis was noted. The criteria for inclusion in the study, in addition to the presence of a coronavirus infection confirmed by PCR, were a laboratory-detected increase in blood amylase and lipase. In the infectious diseases hospital, patients underwent perfusion computed tomogr

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Shabunin, A. V., A. Yu Lukin, D. V. Shikov, and A. A. Kolotilshchikov. "An experience of video-assisted retroperitoneal debridement." Annaly khirurgicheskoy gepatologii = Annals of HPB surgery 23, no. 4 (2019): 93–99. http://dx.doi.org/10.16931/1995-5464.2018493-99.

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Aim. To clarify the indications for video-assisted retroperitoneal debridement at the late stage of pancreatic necrosis. Material and methods. Acute pancreatitis was diagnosed in 1468 patients throughout 2012-2018. Severe destructive pancreatic necrosis occurred in 364 (24.8%) patients. Infected pancreatic necrosis needed for surgical treatment in 264 cases. We used video-assisted retroperitoneal debridement in 20 patients (8.1%).Results. Video-assisted retroperitoneal debridement was not associated with “open” surgery in 6 patients. There were 2-6 redo VARD procedures per patient. We diagnose

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Masyukevich, A. I., P. V. Garelik, N. I. Prokopchik, and A. N. Deshuk. "COMPARATIVE PATHOHISTOLOGICAL EVALUATION OF THE RESULTS OF TREATMENT OF ACUTE DESTRUCTIVE PANCREATITIS IN THE EXPERIMENT." Journal of the Grodno State Medical University 23, no. 2 (2025): 147–54. https://doi.org/10.25298/2221-8785-2025-23-2-147-154.

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Background. Acute destructive pancreatitis (ADP) is a pressing problem in emergency surgery due to the large number of complications and high mortality. The cytokine pathway of interleukin-6 plays an important role in the pathogenesis of ADP, for this reason, inhibition of this pathway seems promising for the treatment of ADP. The purpose of the study: to conduct a comparative analysis of the effect of multicomponent conservative therapy and a combination of conservative treatment with tocilizumab in different dosages on the pathomorphological picture of experimental ADP using the proposed met

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Kotelnikova, L. P., and P. L. Kudryavtsev. "Predictors of external pancreatic fistulas development after surgical treatment of infected pancreatonecrosis." Perm Medical Journal 35, no. 2 (2018): 5–10. http://dx.doi.org/10.17816/pmj3525-10.

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Aim. To determine the risk factors for the development of external pancreatic fistulas in the outcome of infected pancreatonecrosis, which do not close as a result of conservative treatment. Materials and methods. The results of treatment were analyzed in 44 patients with pancreatonecrosis. The influence of different risk factors for the development of external pancreatic fistulas after surgery for infected pancreatonecrosis was studied, using Spearman’s correlation coefficient. Results. The repeated surgeries one year after pancreatonecrosis were required by 9 % of patients in con

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Yang, Jing, Xujiao Tang, Qingqing Wu, Panpan Ren, and Yishu Yan. "A Severe Acute Pancreatitis Mouse Model Transited from Mild Symptoms Induced by a “Two-Hit” Strategy with L-Arginine." Life 12, no. 1 (2022): 126. http://dx.doi.org/10.3390/life12010126.

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To develop a severe acute pancreatitis (SAP) model transited from mild symptoms, we investigated a “two-hit” strategy with L-arginine in mice. The mice were intraperitoneally injected with ice-cold L-arginine (4 g/kg) twice at an interval of 1 h on the first day and subjected to the repeated operation 72 h afterwards. The results showed the “two-hit” strategy resulted in the destructive damage and extensive necrosis of acinar cells in the pancreas compared with the “one-hit” model. Meanwhile, excessive levels of pro-inflammatory mediators, namely IL-6 and TNF-α, were released in the serum. Rem

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Boyko, V. V., O. M. Shevchenko, A. O. Merkulov, and Ye O. Bilodid. "OPTIMIZATION OF SURGICAL TACTICS IN PATIENTS WITH POSTNECROTIC PANCREATIC CYSTS." Kharkiv Surgical School, no. 3 (September 20, 2022): 33–37. http://dx.doi.org/10.37699/2308-7005.3.2022.05.

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Summary. The predominance of people of working age (21-60 years) among patients with pancreatic necrosis, the occurrence of permanent disability in a significant part of patients, high overall and postoperative mortality (20-85 %), due to various complications, turns the treatment of pancreatic necrosis into an important social problem. The frequency of formation of false cysts in acute pancreatitis is 5-16 %, and in destructive forms it increases to 60-80 %. Materials and methods. The scope of endoscopic interventions in the treatment of 16 patients with pancreatic cysts of the pancreas

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Merkulov, A. O., and O. M. Shevchenko. "OPTIMIZATION OF SURGICAL TACTICS IN PATIENTS WITH POSTNECROTIC PANCREATIC CYSTS." Kharkiv Surgical School, no. 4-5 (October 26, 2022): 73–77. http://dx.doi.org/10.37699/2308-7005.4-5.2022.15.

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Summary. The predominance of people of working age (21–60 years) among patients with pancreatic necrosis, the occurrence of permanent disability in a significant part of patients, high overall and postoperative mortality (20–85 %), due to various complications, turns the treatment of pancreatic necrosis into an important social problem. The frequency of formation of false cysts in acute pancreatitis is 5–16 %, and in destructive forms it increases to 60–80 %. Materials and methods. The scope of endoscopic interventions in the treatment of 16 patients with pancreatic cysts of the pancreas

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Baychorov, Enver Khuseynovich, Nikolay Sergeyevich Gandzha, Shamil Rashidovich Salpagarov, and Shakhban Ibragimovich Guseynov. "CHANGES IN THE DYNAMICS OF THE FUNCTIONAL ACTIVITY OF BLOOD GRANULOCYTES IN PATIENTS WITH PANCREATIC NECROSIS." Journal of Experimental and Clinical Surgery 13, no. 1 (2020): 18–23. http://dx.doi.org/10.18499/2070-478x-2020-13-1-18-23.

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The purpose of research. Predicting risk of infection of acute destructive pancreatitis. Material and Methods. The dynamics of functional activity of granulocytes in 27 (58,7%) patients with sterile and 19 (41,3%) patients with infected pancreatic necrosis. An objective assessment of the severity of their condition carried out by performed using of the scale of the integrated assessment APPACHE-II. The exclusion criterion from the study was the revealing of accompanying acute and chronic diseases. Results.Scale APPACHE-II can be used mainly for screening assessment of the degree of

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