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1
Vrubel, Tomáš. "Vybrané modely determinace měnového kurzu." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-75895.
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The aim of this Master Thesis is to summarize the modern theoretical models of fundamental determination of exchange rates. The Thesis contains of Introduction, four explanatory chapters and the conclusion. The first chapter provides the definition of traditional premises (PPP, IRP, expectations) and in the end of the chapter the 5-equation model is introduced. The second chapter focuses the attention on both equilibrium (Bilson-Frenkel) and non equilibrium (Dornbusch, Frankel) monetary models. In the end of the chapter there are also briefly mentioned Hooper-Morton's and Girton-Ropers models. The third chapter brings in the risk and it is focused on portfolio models. The last chapter describes the Lyons-Evans model of market microstructure based on order flow.
2
Pivrnec, Ondřej. "Determinace velikosti rodiny bobra pomocí fotopastí." Master's thesis, Česká zemědělská univerzita v Praze, 2017. http://www.nusl.cz/ntk/nusl-263046.
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This diploma thesis concerns the methodology and subsequent analysis of the quantity of European beaver (Castor fiber) inside a beaver family.
These data were collected by using camera-traps. Collection was conducted from August 2015 to August 2016 in two areas. The first area was the Czech forest and the second area was Šumava. In these areas is a different degree of saturation of the beaver population.
The main objective of this study was to estimate the average size of a beaver family in two model areas using camera-traps. Suitable areas were Czech Forest and Šumava. Secondary objective was to design and test methodology and application of the camera-traps and design a way to evaluate data from the captured images.
3
Černíková, Marie. "Determinace kostýmem v žité a inscenované realitě." Doctoral thesis, Akademie múzických umění v Praze.Divadelní fakulta. Knihovna, 2015. http://www.nusl.cz/ntk/nusl-252316.
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My dissertation focuses on the forms of costume outside the theatre. For its purpose I propose reflecting the western society at the beginning of the second decade of the 21st century as a form of staged (shaped by the abundance of dramatic narrative in media) reality. I discuss the role of mass media in relation to the spectator, e.g. visual and narrative codes effecting our own self representation.
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Jakubec, Pavel. "Ekologické a evoluční strategie nekrofágních brouků (Coleoptera)." Doctoral thesis, Česká zemědělská univerzita v Praze, 2015. http://www.nusl.cz/ntk/nusl-259658.
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Necrophagous beetles (Coleoptera) are very interesting and diverse ecological group of species with an immense impact on a natural nutrient cycle. Their main food source and breeding ground are carrions of vertebrates, human remains included. This relationship is often used in various ways by forensic entomology, but its potential was not jet fully reached, because our knowledge of biology and ecology of these beetles is very much incomplete. In this thesis I would like to explore geographic distribution, ecological requirements and developmental biology of several Central European necrophagous beetles as an outcome of their ecological and evolution strategies. For that I raised three broad research questions. Which factors are determining the local abundance of carrion beetles (Coleoptera: Silphidae)? How the current geographical distribution of open-landscape carrion beetles looks like in the Czech Republic? How the temperature affects the development of Sciodrepoides watsoni (Spence, 1813)? We found out that soil type can have significant effect on abundance of carrion beetles. They showed preference for chernozem -- Nicrophorus antennatus (Reitter), N. germanicus (Linnaeus), N. interruptus (Stephens), N. sepultor (Charpentier), Silpha obscura obscura (Herbst), T. sinuatus (Fabricius) or for fluvisol as did N. humator (Gleditsch). These findings support our hypothesis that soil type could be an important factor determining the occurrence of necrophagous European carrion beetles. To collect novel data of the current geographical distribution of carrion beetles we used 420 baited pitfall traps at 84 localities, and we collected 71 234 specimens of 15 silphid species. Among them, three endangered carrion beetle species listed on the Czech Red List of Invertebrates, were found. Two are vulnerable thermophilic species of open landscapes, Nicrophorus antennatus (Reitter, 1884) (collected around Louny and Židlochovice) and Nicrophorus germanicus (Linnaeus, 1758) (Louny, Zábřeh and Židlochovice). The third is the near threatened species, Nicrophorus sepultor Charpentier, 1825 (collected around Louny, Kutná Hora, Zábřeh and Židlochovice), which also prefers open landscapes. We studied development of common Holarctic beetle Sciodrepoides watsoni under five constant temperature regimes in laboratory (15, 18, 21, 25 and 28°C). Parameters of thermal summation models and their standard errors were calculated for each developmental stage (egg, three larval instars and pupae). We also find a new character for larval instar determination (head width) and proposed novel approach for future studies of size-based characters in instar determination.
5
Kocsisová, Tereza. "Zdanění a doprava." Master's thesis, Vysoká škola ekonomická v Praze, 2016. http://www.nusl.cz/ntk/nusl-262359.
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The aim of this diploma thesis is to find suitable regression models between the chosen statistical data of transport and GDP per capita and determine whether these models are statistically significant. The first part is a theoretical introduction to the problems of transport in terms of economics, as well as a description of methods of regression analysis, which is used in the practical part. The practical part draws data from Eurostat's website that provide for this thesis sufficient statistical basis. The data are graphically processed as scatter charts, based on these are determined mathematical equation of regression. The choice of suitable regression analysis is based on coefficient of determination and significance level is alpha = 0,05.
6
Šimonová, Kamila. "Posouzení finanční výkonnosti podniku pomocí analýzy časových řad." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2015. http://www.nusl.cz/ntk/nusl-225021.
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This master’s thesis covers analysis of financial performance of company Jessgrove Central Europe s.r.o through analysis of time lines. Theoritical part is focused on definition of basic terms relating to analysis of time lines and regression analysis. In practical part, current situation of the Company is analysed. The conclusion brings own suggestions to improve current financial situation of the Company.
7
Jansa, Jakub. "Stochastická předpověď průměrných měsíčních průtoku ve vybraném vodoměrném profilu." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2016. http://www.nusl.cz/ntk/nusl-240072.
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The diploma thesis is focused on the average monthly flows forecast in the selected hydrometric profile. Aim of this work will be evaluation of the calculated values and the interpretation of the results in understandable form. The next step will be find an appropriate connection between randomly-generated inputs in the form of random real flow series using the standard hydrological prediction models. This models are based on the principles of artificial intelligence and probability model. The result of the work will be verification of procedures and compilation of mean monthly flow stochastic forecast in selected hydrometric profile, which would be used for a reservoirs management, respectively for water systems management.
8
Levorato, Gabriela Baptistella Peres [UNESP]. "Matrizes, determinantes e sistemas lineares: aplicações na Engenharia e Economia." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/151612.
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Previous issue date: 2017-08-18<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O presente trabalho mostra a importância da Álgebra Linear e em particular da Teoria de Matrizes, Determinantes e Sistemas Lineares para resolver problemas práticos e contextualizados. Mostramos aplicações em circuitos elétricos, no balanceamento de equações químicas, nos modelos aberto e fechado de Leontief, e no funcionamento do GPS. Ainda, foi aplicado um plano de aula para os alunos do segundo ano do Ensino Médio e apresentamos sugestões de exercícios de vestibulares sobre os tópicos estudados, para serem abordados em sala de aula.<br>The present work shows the importance of Linear Algebra and in particular of Matrix Theory, Determinants and Linear Systems to solve practical and contextualized problems. We show applications in electrical circuits, in the balancing of chemical equations, in the open and closed models of Leontief, and in the operation of GPS. Also, a lesson plan was applied to the students of the second year of high school and we presented suggestions of exercises of vestibular about the topics studied, to be approached in the classroom.
9
Moro, Eliton Mendonça [UNESP]. "Códigos de bloco espaço-temporais via corpos quadráticos." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/148757.
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Previous issue date: 2017-01-30<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Os sistemas de comunicação com Múltiplas Entradas e Múltiplas Saídas (MIMO), são sistemas constituídos por estruturas que utilizam várias antenas, tanto no transmissor como no receptor. Por serem transmitidos via antenas, naturalmente surgem problemas de ruídos e de multipercursos, que impõe um desafio para o desenvolvimento dos sistemas de comunicação MIMO. Por esses motivos, muitos estudos focam em certas propriedades dos sinais enviados a fim de minimizar os efeitos sofridos na informação durante a transmissão. Existem muitos tipos diferentes de Códigos de Bloco Espaço-Temporais (STBC) disponíveis para duas antenas transmissoras, dentre eles, o código de bloco espaço-temporal ciclotômico, Código de Ouro e Código de Prata. Neste trabalho apresentamos uma construção de STBC cujos os sinais utilizados na transmissão são identificados por elementos de anéis de inteiros de corpos de números totalmente imaginários, Q(√d), com d<0, e apresentamos os melhores STBC em termos do critério que denominamos como critério produto, considerando extensões de Q(√d) com d=-1,-2,-3,-7, -11.<br>The communication systems of Multiple Input and Multiple Output (MIMO), are systems consisting of structures that use multiple antennas, both on the transmitter and the receiver. For being transmitted via antennas, noise and path problems naturally arise, which poses a challenge for the development and optimization of MIMO systems. For these reasons, many studies focus on certain properties of the signals sent in order to minimize the effects suffered on the information during transmission. There are many different types of Space-Time Block Codes (STBC) available for two transmitting antennas, such as the cyclotomic space-time block code, Golden code, and Silver code. In this work, we present a STBC construct via totally imaginary quadratic fields, Q(√d) with d <0 and present the best STBC in terms of the criterion that we call product criteria, considering extensions of Q(√d) with d = -1, - 2, - 3, - 7, -11.
10
Sapien, Cordoba Abraham. "The Unpleasantness of Pain." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUL089.
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La douleur est désagréable. Étant donné que la douleur est l'exemple paradigmatique d'une expérience désagréable, mon but est de clarifier ce qui caractérise la douleur et le caractère désagréable. J’essaie notamment de comprendre ce que peut signifier qu’une douleur soit désagréable et ainsi d’élucider la structure des expériences désagréables. Ce faisant, j’aborde plusieurs aspects problématiques de la relation entre la douleur et le caractère désagréable des expériences. Je fournis également une compréhension générale de ce que signifie pour une expérience non nécessairement douloureuse d’être désagréable. Cette thèse s’organise en sept chapitres correspondant à trois problématiques principales : i) qu’est-ce qui constitue le caractère désagréable de la douleur ? (Chapitres 1 & 2), ii) comment rendre compte de la grande diversité phénoménale du caractère désagréable des expériences ? (Chapitres 3 & 4), et iii) dans quels cas la douleur n’est-elle pas désagréable ? (Chapitres 5 & 6). Dans le dernier chapitre (Chapitre 7), j'offre une réponse générale aux trois problématiques principales en proposant ma propre théorie sur le caractère désagréable de la douleur. D’après cette théorie, une expérience désagréable est une expérience ressentie, le caractère désagréable est défini comme une propriété phénoménale des états mentaux, et cette propriété doit être comprise en utilisant la distinction déterminable-déterminant. Mon travail fournit ainsi une compréhension détaillée de la nature de la douleur et du caractère désagréable<br>Pain is unpleasant. Given that pain is the paradigmatic example of an unpleasant experience, I aim to shed light on what pain and unpleasantness are by trying to understand what it means for a pain to be unpleasant, what the structure of unpleasantness is, and by tackling several problematic aspects of the relation between pain and unpleasantness. By doing this, I will also provide a general account of what it means for an experience that might not be a pain to be unpleasant.The thesis is organised into seven chapters and divided by three main themes: i) what the unpleasantness of pain consists in, ii) how we can account for the great phenomenal diversity among experiences of unpleasantness, and iii) which cases suggest that there could be pains that are not unpleasant. Broadly, the first two chapters deal with the first theme, the third and fourth chapter with the second theme, and the fifth and sixth chapter focus on the third theme. In the final chapter I offer a conclusion of the three main themes by providing my own view on the unpleasantness of pain. According to this account, an unpleasant experience is something felt, it is a phenomenal property of mental states, and this property should be understood using the determinable-determinate distinction. By doing all of this, this thesis will provide a detailed understanding of the nature of pain and unpleasantness
11
Petrlíková, Petra. "Posouzení vybraných ukazatelů firmy pomocí analýzy časových řad." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-241596.
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The diploma thesis deals with an assessing selected indicators of a KAVALE company s. r. o. using time series analysis. Issues of financial analysis, analysis of period lines, regressive analysis and correlative analysis are described in a theoretical part. Practical part is focused on statistic analysis of selected indicators of financial analysis. Its aim is to reveal dependance between indicators and prediction of their future development for the next two periods of time. Comparison of the analyzed company with an average sector and with two rival companies is also part of the practical section. On the basis of these analyzes I recommend proposals to improve the financial situation of the company.
12
Luska, Zbyněk. "Statistická analýza vad ve stavební praxi." Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-260146.
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This thesis on statistical analysis of defects in construction practice deals with the assessment of defects which are monitored within the system of construction and technical prevention in the period from 2010 to 2013. We cannot consider as defects such matters arising from non-compliance with the contractual relationship between the sponsor and implementer of the building work, and that this does not contradict the building Act. This thesis aims to determine the defects in construction practice and the right tools, statistical analysis, and quality control methods to assess the state and evolution of defects, as well as to find links and dependence of defects on defined factors. The methodological part of the thesis is based on an exploratory statistical analysis of qualitative data, Pareto analysis, and also statistical testing of the hypothesis of independence using the chi-square test of independence in the pivot table. The strength of any relationship is tested under Cramér V. The output of the thesis is a list of the most frequently occurring defects in construction practice, a description of the defects, and their evaluation in terms of occurrence in time, within a defined territory, and the occurrence of a specific building construction.
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Šelepa, Milan. "Středně dobá předpověď průtoků vody měrným profilem toku." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2015. http://www.nusl.cz/ntk/nusl-227194.
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The diploma thesis is focused on the long term prediction of mean monthly flows in hydrometric profile for purposes of reservoir control optimization and optimization of reservoir systems. Discharges were predicted using by artificial neural network method. Predicted flows were statistically evaluated by relevant coefficients and then compared with the measured flows for given river hydrometric profiles.
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Prata, Gustavo Gomes. "Determinantes." Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/8728.
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Previous issue date: 2016-10-04<br>Não recebi financiamento<br>This paper wants to provide subsidies to the Mathematics teacher of
Basic Education, regarding to Determinants. From a consistent theoretical
basis, it builds the concept of Determinant and deducts its main properties.
Subsequently, it presents some of its applications, which can be explored in
High School, linked to the historical context in which they were developed,
aiming to make learning of Determinants more significant.
Thereby, the Chapter 1 presents basic concepts of Linear Algebra, which
are prerequisites for the definition and study of the Determinant Function, as
well as of its properties, which are developed in Chapter 2. Chapter 3, on the
other hand, promotes connections of Determinants with other middle-level
mathematical concepts related to the own Linear Algebra and Analytic and
Euclidean Geometry, each one with a specific historical introduction.<br>O presente trabalho busca fornecer subsídios ao professor de Matemática
da Educação Básica, no que se refere ao tema Determinantes. A partir de
uma base teórica consistente, o conceito de Determinante _e construído e
suas principais propriedades são deduzidas. Posteriormente, são apresentadas
algumas de suas aplicações, passíveis de serem exploradas no Ensino Médio,
vinculadas ao contexto histórico na qual foram desenvolvidas, buscando
tornar a aprendizagem de Determinantes mais significativa.
Desse modo, o capítulo 1 apresenta conceitos básicos de Álgebra Linear,
que são pré-requisitos para a definição e o estudo da Função Determinante,
bem como de suas propriedades, que são desenvolvidas no capítulo 2. O
capítulo 3, por sua vez, promove conexões de Determinantes com outros
conceitos matemáticos de nível médio relativos à própria Álgebra Linear e às
Geometrias Analítica e Euclidiana, cada qual com uma introdução histórica
específica.
15
Crone, Logan. "Determinacy of Schmidt's Game and Other Intersection Games." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1703306/.
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Schmidt's game, and other similar intersection games have played an important role in recent years in applications to number theory, dynamics, and Diophantine approximation theory. These games are real games, that is, games in which the players make moves from a complete separable metric space. The determinacy of these games trivially follows from the axiom of determinacy for real games,ADR, which is a much stronger axiom than that asserting all integer games are determined, AD. One of our main results is a general theorem which under the hypothesis AD implies the determinacy of intersection games which have a property allowing strategies to be simplified. In particular, we show that Schmidt's (α,β,ρ) game on R is determined from AD alone, but on Rn for n≥3 we show that AD does not imply the determinacy of this game. We then give an application of simple strategies and prove that the winning player in Schmidt's (α,β,ρ) game on R has a winning positional strategy, without appealing to the axiom of choice. We also prove several other results specifically related to the determinacy of Schmidt's game. These results highlight the obstacles in obtaining the determinacy of Schmidt's game from AD
16
Doherty, Andrew James. "Determinacy and vagueness." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266702.
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Liu, Liu. "Un análisis comparativo del sintagma determinante (SDet) en Español y Chino." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/322087.
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La presente tesis es un análisis comparativo del Sintagma Determinante en español y chino. De acuerdo con Cinque y Kayne (2005), la comparación entre lenguas es una parte esencial de la lingüística formal. El estudio de lenguas o dialectos estrechamente relacionados ha demostrado que las diferencias sintácticas entre las lenguas son menos importantes de lo que a primera vista podrían parecer, y ha ayudado a identificar los principios fundamentales de la Gramática Universal (GU). Las lenguas altamente flexionadas, como el español, son tanto tipológicamente como genéticamente distintas de las lenguas radical-aislantes, como el chino. Aparentemente una comparación lingüística entre las dos no tiene mucho valor investigador porque ambas lenguas no presentan muchas similitudes. No obstante, si las analizamos desde un punto de vista generativo, los rasgos distintivos de cada una cumplen con determinados principios comunes, lo cual aportaría pruebas más convincentes para la demostración de la GU.
En la bibliografía lingüística moderna, debido a la propuesta de la proyección extendida que concede importancia a la proyección de las categorías funcionales y el descubrimiento de diversos paralelismos entre el sintagma nominal y la oración, ha habido estudios abundantes sobre la proyección nominal y las proyecciones superiores encabezadas por categorías funcionales en los nuevos análisis, sobre todo, la proyección del determinante. La hipótesis del SDet (Abney 1987) renueva el antiguo concepto del sintagma nominal y postula que el sintagma determinante subcategoriza la proyección nominal. La propuesta ha sido polémica porque se fundó en una categoría funcional que en algunas lenguas falta, como sucede en esta investigación: en español hay artículos pero en chino esta categoría no existe.
Por lo tanto, esta tesis tiene el propósito de analizar comparativamente las construcciones del sintagma determinante en chino y en español, encontrar las similitudes y distinciones sintácticas y semánticas y proponer que, aunque los SSDD se proyecten de modo muy distinto en español y chino, presentan similitudes derivadas de los principios de la GU.<br>This dissertation is a comparative analysis of Determiner Phrase in Spanish and in Chinese. According to Cinque and Kayne (2005), comparison between languages is an essential part of formal linguistics. The study of closely related languages or dialects has shown that syntactic differences between languages are less important than they might appear at first sight, and has helped to identify the fundamental principles of Universal Grammar (UG). The highly inflected languages such as Spanish are both typologically and genetically different from the radical isolating languages like Chinese. Seemingly, a linguistic comparison between these two does not have much research value because there are not many similarities between them. However, if we analyze them from a generative point of view, the distinctive features of each language comply with certain common principles, which would provide more convincing demonstration of UG.
In modern linguistic literature, due to the proposal of the extended projection that attaches importance to the projection of functional categories and the discovery of various parallels between the noun phrase and the clause, there have been numerous studies on the nominal projection and higher projections headed by functional categories in the new analysis, particularly, the projection of determiners. The hypothesis of DP (Abney 1987) renews the ancient concept of the noun phrase and postulates that the determiner phrase subcategorizes the nominal projection. The proposal has been controversial because it was based on a functional category that some languages lack, as in this research: there are articles in Spanish but in Chinese this category does not exist.
Therefore, this investigation aims to analyze comparatively determiner phrases in Chinese and in Spanish, to find the syntactic and semantic similarities and distinctions and to propose that although the determiners project very differently in Spanish and in Chinese, present similarities derived from the principles of UG.
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Vasconcellos, Luiz Fernando Nascimento. "Utilização do método de Gauss-Jordan no ensino médio." Universidade Federal de Juiz de Fora, 2014. https://repositorio.ufjf.br/jspui/handle/ufjf/817.
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Previous issue date: 2014-03-18<br>CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Este trabalho é voltado para professores e alunos do Ensino Médio. Tem como objetivo
mostrar a utilização do Método da Eliminação de Gauss-Jordan para a resolução de sistemas
de equações lineares, cálculo de matrizes inversas e cálculo de determinantes. A motivação
para a escolha desse tema é que, cada vez mais, o estudo das matrizes, dos determinantes e,
consequentemente, dos sistemas de equações lineares vem sendo deixado de lado no Ensino
Médio. Inicialmente, é feito um pequeno apanhado sobre o que são matrizes equivalentes
e operações elementares, além de se falar sobre cofator de um elemento de uma matriz
e sobre matriz adjunta, necessária para o cálculo da inversa utilizando-se determinantes.
Apresenta-se um pouco da história de Gauss e de Jordan e, logo em seguida, o método
propriamente dito. Também é visto o que acontece com o método quando as matrizes não
são invertíveis, os sistemas são possíveis e indeterminados ou os sistemas são impossíveis.
Quanto aos determinantes, são apresentadas suas propriedades e mostrada a eficácia do
método para determinantes de ordem n 3 e, além disso, é mostrada a aplicação dos
determinantes no cálculo de inversas e na resolução de sistemas de equações pela Regra de
Cramer. Finalmente, são apresentadas sugestões de exercícios com uma breve resolução.<br>This work is oriented to teachers and students in the high school. It aims to show the usage
of Gauss-Jordan’s Elimination Method to solve systems of linear equations, calculation of
inverse matrices and determinants. The motivation behind the selection of this topic is
that, more and more, the study of matrices, determinants, and consequently, systems of
linear equations has been ignored in the high school. Firstly, an abridgement is done on
what equivalent matrices and elementary operations are. Secondly, it explains about the
cofactor of an element of a matrix and about adjoint matrices, needed for the calculation
of the inverse matrix using determinants. A little introduction of Gauss and Jordan’s
histories is made, and then, the method itself. It is also shown what happens with the
method when the matrices are not invertible, the systems are possible but undetermined,
or, the systems are not possible. Concerning determinants, their properties are presented
and the method’s efficacy for determinants of order n 3 is shown and furthermore, it
is shown the application of the determinants in the calculation of inverse matrices and
resolutions of systems using Cramer’s Rule. Finally, some suggestions for exercises are
presented with brief resolutions.
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Stanton, Samantha. "The Axiom of Determinacy." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2189.
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Working within the Zermelo-Frankel Axioms of set theory, we will introduce two important contradictory axioms: Axiom of Choice and Axiom of Determinacy. We will explore perfect polish spaces and games on these spaces to see that the Axiom of Determinacy is inconsistent with the Axiom of Choice. We will see some of the major consequences of accepting the Axiom of Determinacy and how some of these results change when accepting the Axiom of Choice. We will consider 2-player games of perfect information wherein we will see some powerful results having to do with properties of the real numbers. We will use a game to illustrate a weak proof of the continuum hypothesis.
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Bryant, Ross. "Borel Determinacy and Metamathematics." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc3061/.
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Borel determinacy states that if G(T;X) is a game and X is Borel, then G(T;X) is determined. Proved by Martin in 1975, Borel determinacy is a theorem of ZFC set theory, and is, in fact, the best determinacy result in ZFC. However, the proof uses sets of high set theoretic type (N1 many power sets of ω). Friedman proved in 1971 that these sets are necessary by showing that the Axiom of Replacement is necessary for any proof of Borel Determinacy. To prove this, Friedman produces a model of ZC and a Borel set of Turing degrees that neither contains nor omits a cone; so by another theorem of Martin, Borel Determinacy is not a theorem of ZC. This paper contains three main sections: Martin's proof of Borel Determinacy; a simpler example of Friedman's result, namely, (in ZFC) a coanalytic set of Turing degrees that neither contains nor omits a cone; and finally, the Friedman result.
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Bix, Brian. "Wittgenstein and legal determinacy." Thesis, University of Oxford, 1991. https://ora.ox.ac.uk/objects/uuid:fd66944d-fc4b-4b67-8824-3c820900b49f.
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In the jurisprudential literature, much attention has recently been given to the role of language within law, with various writers asserting that certain theories of meaning or theories of interpretation offer new insights into the nature of law. My survey of portions of this on-going debate will have two overlapping foci: the issue of legal determinacy and the application of Ludwig Wittgenstein's ideas to legal theory. In the context of a number of different discussions, I argue that a proper understanding of the nature of language and its role within law compels neither the conclusion that law is radically indeterminate nor the conclusion that law is completely determinate. I disagree with the usual reading of H.L.A. Hart on "open texture", arguing instead that Hart's argument was as much about the proper way to apply legal rules as it was about the nature of language. I offer a reading of Wittgenstein's rule-following considerations which differs from Saul Kripke's reading as well as from the reading some legal theorists have offered, and which I believe justifies only a modest view of the direct applicability of Wittgenstein to jurisprudence. I argue that Ronald Dworkin's recent work leaves a number of unresolved questions regarding right-answer theories and that there are basic difficulties with his holistic-interpretative approach to law. Finally, I discuss Wittgenstein's critique of platonism as part of an argument that Michael Moore's metaphysically realist approach to law offers no advantages compared to more conventional approaches.
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Kovachev, Bogomil. "Some Axioms of Weak Determinacy." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-109320.
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Sandro, Paolo. "Creation and application of law : a neglected distinction." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/25862.
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The thesis investigates the deep conceptual structure of the distinction between creation and application of law. Legal philosophers either take the distinction for granted (and so do the vast majority of legal scholars in general) or, when they address it directly, it is so for the only purpose of criticising it as just another upshot of legal formalism. The latter approach suggests the distinction is either unsound or, at the very least, useless. The thesis argues that supporters of this stance do not realise the implications of their positions – which transcend legal-theoretical discourse and raise serious problems in both political and constitutional theory. The thesis’s first chapter purports to show that our models of constitutional democracy – as a complex set of institutional power-constraining mechanisms - are ultimately grounded on the distinction between creation and application of law. Hence the theoretical unsoundness of the distinction would undermine the very foundations of such democracies. The thesis argues that if judges are always creating the law, it follows that nothing like the ‘application of law’ is possible and, as a result, there is little or no justification for the practice of having statutes and other institutionalised forms of law. In this regard, Chapter 2 argues that realist theories of adjudication cannot make sense of one of law’s most important features, namely its normativity. More generally, undergirding a certain conception of our current adjudicative practices is the idea of (judicial) discretion, which is an essentially legal concept. In Chapter 3 I discuss this idea, comparing how it is conceived and used in both jurisprudence and administrative law (where such notion has been originally developed, at least in civil-law jurisdictions). The chapter aims at showing that an appropriate conception of discretion plays a pivotal role in grounding an analytical distinction between creation and application of law. Chapter 4 fleshes out the deeper philosophical assumptions of such distinction and, more specifically, it puts forward a conception of ‘law as communication’ which highlights the inescapable relation between law and language, and the parallel relation between philosophy of law and philosophy of language. In this chapter, I also argue that philosophy of language can and should play a role in understanding what law is, but that, at the same time, law is a unique communicative phenomenon, whose characteristics call for an original theoretical analysis. Finally, Chapter 5 brings together the several threads of the argument and presents the analytical model of the distinction between creation and application of law. The conclusion is that the creation/application distinction, thus conceived, is necessary not just in order to defend our liberal political practices - but more fundamentally, to account for law’s own raison d'être as a power-constraining device.
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Vescovi, Edoardo. "Perturbative and non-perturbative approaches to string sigma-models in AdS/CFT." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17612.
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Diese Doktorarbeit behandelt quantentheoretische Aspekte von Typ II Superstringtheorien in AdS5xS5- und AdS4xCP3-Hintergründen für die AdS/CFT Korrespondenz. Dabei werden perturbative Methoden und Verfahren der Gitterfeldtheorie benutzt. Die Konstruktion des Supercoset-Sigma-Modell für Strings im AdS5xS5wird skizziert, während die generelle Quantendynamik des Superstring in AdS4xCP3 mit Hilfe einer dimensionaler Reduktion der Supermembrane-Wirkung in AdS4xS7 beschrieben wird. Ein manifest kovarianter Formalismus zur semi-klassischen Quantisierung von Strings um beliebige Minimalflächen in AdS5xS5 wird präsentiert, der durch die Darstellung der Fluktuationsoperatoren in Form von intrinsischen und extrinsischen Varianten der Hintergrundgeometrie erreicht wird. Eine Verallgemeinerung der Lame-Differentialgleichung zur 4. Ordnungwird mit Hilfe der Spektralmethode exakt gelöst. Dadurch konnten in 1-Schleifennäherung die Energie des String im SU(2)-Sektor, im Grenzfall beschrieben durch ein Quantum-Landau-Lifshitz-Modell, und der bosonische Beitrag zur Energie des in AdS5 und S5 rotierenden String bestimmt werden. In ähnlicher Weise erhält man in 1-Schleifennäherung den ¼-BPS-Latitude Wilson-Loop in N=4-SYM-Theorie normiert durch den ½-BPS-Loop. Das Regularisierungsschema reproduziert die Vorhersage aus supersymmetrischer Lokalisierung bis auf einen Rest, welcher diskutiert wird. Außerdem wird die Wirkung des AdS4xCP3-String, entwickelt um den null-cusp Hintergrund, studiert und die Cusp-Anomalie in 2-Schleifennäherung berechnet. Das Ergebnis stimmt mit dem vermuteten exakten Ausdruck, der ABJM-Interpolationsfunktion, überein. Schließlich wird die AdS5xS5-Superstringtheorie in AdS-Lichtkegel-Eichung diskretisiert und mit Monte-Carlo-Algorithmen Gittersimulationen bei endlicher Kopplung durchgeführt. Dabei werden die Stringwirkung, aus der mit Hilfe von AdS/CFT die null-cusp anomale Dimension von N=4 SYM extrahiert werden kann, und die Masse einer AdS Anregung bestimmt.<br>This thesis discusses quantum aspects of type II superstring theories in AdS5xS5 and AdS4xCP3 backgrounds relevant for the AdS/CFT correspondence, using perturbative methods at large string tension and lattice field theory techniques inspired by a work of Roiban and McKeown. We review the construction of the supercoset sigma-model for strings in the AdS5xS5 background, whereas the general quantum dynamics of the superstring in AdS4xCP3 is described by a double dimensional reduction of the supermembrane action in AdS4xS7. We present a manifestly covariant formalism for semiclassical quantization of strings around arbitrary minimal-area surfaces in AdS5xS5, expressing the fluctuation operators in terms of intrinsic and extrinsic invariants of the background geometry. We exactly solve the spectral problem for a fourth-order generalization of the Lame'' differential equation with doubly periodic coefficients in a complex variable. This calculates the one-loop energy of the (J1,J2)-string in the SU(2) sector in the limit described by a quantum Landau-Lifshitz model and the bosonic contribution to the energy of the (S,J)-string rotating in AdS5 and S5. Similar techniques calculate the 1/4-BPS latitude Wilson loops in N=4 SYM theory at one loop, normalized to the 1/2-BPS circular loop. Our regularization scheme reproduces the next-to-leading order predicted by supersymmetric localization, up to a remainder function that we discuss upon. We also study the AdS4xCP3 string action expanded around the null cusp background and compute the cusp anomaly up to two loops. This agrees with an all-loop conjectured expression of the ABJM interpolating function. We finally discretize the AdS5xS5 superstring theory in the AdS light-cone gauge and perform lattice simulations at finite coupling with a Monte Carlo algorithm. We measure the string action, from which we extract the null cusp anomalous dimension of N=4 SYM as derived from AdS/CFT, as well as the mass of an AdS excitation.
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LUGON, MARCELO DI M. V. "Determinacao de Sn(." reponame:Repositório Institucional do IPEN, 2008. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9523.
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Made available in DSpace on 2014-10-09T12:27:37Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:04:29Z (GMT). No. of bitstreams: 0<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Loosli, Isabelle. "Erfassung der Zahlungsbereitschaft bei Styling-Produkten Eine empirische Untersuchung der maximalen Zahlungsbereitschaft unter Berücksichtigung beeinflussender Determinanten /." St. Gallen, 2008. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/01652163002/$FILE/01652163002.pdf.
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Belleri, Delia <1983>. "Semantic under-determinacy, Content and Context." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4980/.
Full textAbstract:
The aim of the thesis is to investigate the topic of semantic under-determinacy, i.e. the failure of the semantic content of certain expressions to determine a truth-evaluable utterance content. In the first part of the thesis, I engage with the problem of setting apart semantic under-determinacy as opposed to other phenomena such as ambiguity, vagueness, indexicality. As I will argue, the feature that distinguishes semantic under-determinacy from these phenomena is its being explainable solely in terms of under-articulation. In the second part of the thesis, I discuss the topic of how communication is possible, despite the semantic under-determinacy of language. I discuss a number of answers that have been offered: (i) the Radical Contextualist explanation which emphasises the role of pragmatic processes in utterance comprehension; (ii) the Indexicalist explanation in terms of hidden syntactic positions; (iii) the Relativist account, which regards sentences as true or false relative to extra coordinates in the circumstances of evaluation (besides possible worlds). In the final chapter, I propose an account of the comprehension of utterances of semantically under-determined sentences in terms of conceptual constraints, i.e. ways of organising information which regulate thought and discourse on certain matters. Conceptual constraints help the hearer to work out the truth-conditions of an utterance of a semantically under-determined sentence. Their role is clearly semantic, in that they contribute to “what is said” (rather than to “what is implied”); however, they do not respond to any syntactic constraint. The view I propose therefore differs, on the one hand, from Radical Contextualism, because it stresses the role of semantic-governed processes as opposed to pragmatics-governed processes; on the other hand, it differs from Indexicalism in its not endorsing any commitment as to hidden syntactic positions; and it differs from Relativism in that it maintains a monadic notion if truth.<br>Scopo della tesi è indagare il tema della sottodeterminazione semantica, ossia il fenomeno per cui il contenuto semantico di un'espressione non determina un contenuto passibile di valutazione per i propri proferimenti. Nella prima parte della tesi, affronto il problema di come distinguere la sottodeterminazione semantica da fenomeni quali ambiguità, vaghezza, indicalità. Sosterrò che ciò che distingue la sottodeterminazione semantica è la possibilità di spiegarla unicamente in termini di sotto-articolazione. Nella seconda parte della tesi, discuto il problema di come la comunicazione sia possibile, nonostante la sottodeterminazione semantica. Prendo in considerazione varie risposte: (i) il Contestualismo Radicale, per cui processi pragmatici intervengono nella comprensione dei proferimenti; (ii) la spiegazione Indicalista, in termini di posizioni articolate in sintassi profonda; (iii) il Relativismo, secondo cui gli enunciati sono veri o falsi rispetto a coordinate aggiuntive nelle circostanze di valutazione (oltre ai mondi possibili). Nel capitolo finale, propongo un resoconto per cui la comprensione di enunciati sottodeterminati si avvale di vincoli concettuali. I vincoli concettuali sono modi di organizzare l'informazione che regolano il pensiero e il discorso. Nella prospettiva che difendo, i vincoli concettuali vengono sfruttati dall'ascoltatore per ricostruire il contenuto di un proferimento sotto-determinato. Il ruolo dei vincoli concettuali è senza dubbio semantico, poiché essi contribuiscono a determinare “ciò che è detto” (non “ciò che è implicato”). Ciononostante, essi non rispondono ad alcun vincolo sintattico. La mia proposta si discosta dal Contestualismo Radicale, perché dà risalto a processi semantici anziché a processi pragmatici. D'altro canto, si discosta dall'Indicalismo nel non postulare posizioni nascoste in sintassi profonda; infine, differisce dal Relativismo poiché mantiene una nozione monadica di verità.
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Henrio, Ludovic. "Asynchronous object calculus : confluence and determinacy." Nice, 2003. http://www.theses.fr/2003NICE4047.
Full textAbstract:
L'objectif de cette thèse est de concevoir un calcul d'objets permettant d'écrire des applications parallèles et distribuées, en particulier dans un cadre à grande échelle, tout en assurant de bonnes propriétés. Le calcul proposé s'intitule ASP : Asynchronous Sequential Processes. Les principales caractéristiques de ce calcul sont : des communications asynchrones, la présence de futurs et une exécution séquentielle dans chacun des processus. Ce calcul exhibe de fortes propriétés de confluence et de déterminisme. Cette thèse a donc aussi pour objectif de prouver de telles propriétés dans un cadre aussi général que possible. ASP est basé sur une répartition des objets en différentes activités disjointes. Une activité est un ensemble d'objets gérés par un unique processus. Les objets actifs sont des objets accessibles par des références globales/distantes. Ils communiquent à travers des appels de méthodes asynchrones avec un mécanisme de futurs. Un futur est une référence globale désignant un résultat qui n'est pas encore calculé. Cette thèse modélise ces différents aspects, leurs principales propriétés et les conséquences de ces mécanismes sur la notion de comportement déterministe des programmes. Le résultat principal consiste en une propriété de confluence et son application à l'identification d'un ensemble de programmes se comportant de façon déterministe. Du point de vue pratique, ASP peut aussi être considéré comme une modélisation de la librairie ProActive. Cette librairie fournit des outils pour développer des applications parallèles et distribuées en Java<br>The objective of this thesis is to design an object calculus that allows one to write parallel and distributed applications, particularly on wide range networks, while ensuring good properties. This calculus is named ASP : Asynchronous Sequential Processes. The main characteristics of ASP are: asynchronous communications, futures, and a sequential execution within each process. ASP presents strong confluence and determinism properties, proved in a context as general as possible within this thesis. A first design decision is the absence of sharing : objects live in disjoint activities. An activity is a set of objects managed by a unique process and a unique active object. Active objects are accessible through global/distant references. They communicate through asynchronous method calls with futures. A future is a global reference representing a result not yet computed. This thesis models those aspects, their main properties, and the consequences of these mechanisms on the deterministic behavior of programs. The main result consists in a confluence property and its application to the identification of a set of programs behaving deterministically. From a practical point of view, ASP can also be considered as a model of the ProActive library. This library provides tools for developing parallel and distributed applications in Java
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Walker, Daniel. "Determinacy-related Consequences on Limit Superiors." Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc271913/.
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Laczkovich proved from ZF that, given a countable sequence of Borel sets on a perfect Polish space, if the limit superior along every subsequence was uncountable, then there was a particular subsequence whose intersection actually contained a perfect subset. Komjath later expanded the result to hold for analytic sets. In this paper, by adding AD and sometimes V=L(R) to our assumptions, we will extend the result further. This generalization will include the increasing of the length of the sequence to certain uncountable regular cardinals as well as removing any descriptive requirements on the sets.
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Brennan, Benjamin. "Essays on Nominal GDP Targeting." Thesis, University of Oregon, 2018. http://hdl.handle.net/1794/23784.
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The subject of this dissertation is nominal GDP (NGDP) targeting. In the wake of the Great Recession, some economists have proposed using some form of NGDP target to replace current monetary policy. We evaluate the desirability of NGDP targets based upon their ability to deliver unique and \learnable" equilibria and their welfare gains in the presence of nancial frictions.
In the second chapter, we assess the determinacy and E-stability conditions for simple interest rate rules which respond to NGDP's deviation from target in a simple three-equation New Keynesian model. The rules under consideration target either NGDP level or growth, and can either be contemporaneous, one period ahead, or two periods ahead. We also allow for dierent types of information sets for the agents.
In the third chapter, we compare welfare loss in consumption equivalent terms for NGDP targets with more conventional monetary policy in a New Keynesian model which features nancial frictions.
Finally, in the fourth chapter we continue our analysis from chapter one but now allow for strictly positive trend inflation. We present
findings for the relationship between trend inflation and the determinacy and E-stability of the equilibrium when using interest rate rules that target NGPD.
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Cotton, Michael R. "Determinacy in the Low Levels of the Projective Hierarchy." Miami University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=miami1343245802.
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au, craig pace@murdoch edu, and Craig Stuart Pace. "The Influence of Apobec3g and Deoxythymidylate Kinase Genetic Diversity on Hiv-1 Hypermutation and Response to Treatment." Murdoch University, 2006. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20070515.114340.
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This thesis addresses two important topics in HIV-1 medicine; (i) the clinical
relevance of pre-treatment G-A hypermutation and the contribution of host and
viral genetics to its development and; (ii) the influence of genetic variation in host
enzymes responsible for antiretroviral drug metabolism on response to therapy.
These themes are outlined below.
HIV-1 Hypermutation
At present, limited data exists regarding the relative roles of host encoded cytidine
deaminases APOBEC3G and APOBEC3F in promoting G-A hypermutation of
HIV-1 proviral DNA in vivo, nor the clinical relevance of hypermutation or the
influence of genetic diversity of the APOBEC3G locus and of the viral encoded vif
protein that counteracts the action of APOBEC3G. The analyses contained within
this thesis demonstrate that within the WA HIV cohort, clinically relevant
hypermutation is restricted to a minority of individuals and is mediated
predominantly by APOBEC3G. In this study, the presence of HIV-1 hypermutation
had a substantially greater effect on plasma viremia than other known host antiviral
factors such as CCR5D32 or specific HLA-B alleles. Furthermore, the considerable
genetic diversity of the vif gene is likely to make a greater contribution to the
development of hypermutation than the limited genetic diversity of the APOBEC3G
gene in Caucasians. These data indicate that G-A hypermutation is a clinically
relevant phenomenon and may provide a fresh perspective to the area of HIV/AIDS
therapies.
Genetic Determinant of HIV-1 Treatment Response
Thymidine kinase 2 (TK2) and thymidylate kinase (dTMPK) are rate limiting
enzymes for the metabolism of the antiretrovirals d4T and AZT, respectively, and
are thus central to the antiviral efficacy and toxicity of these agents. However, the
genetic diversity of TK2 and dTMPK and their influence on toxicities associated
with their use is largely unknown. The results discussed in this thesis indicate that in
contrast to the highly conserved TK2 locus, the dTMPK locus of Caucasian
individuals, including regulatory regions potentially influencing transcription and
translation, is considerably polymorphic and organised into five common haplotypes.
The results regarding the contribution of dTMPK genetic variation to toxicities
associated with AZT therapy are encouraging. A common dTMPK haplotype had
significant, albeit modest, effect on haematological parameters (haemoglobin and
mean corpuscular volume) in HIV-infected patients, although no AZT-specific
treatment effect was observed in this relatively haematologically stable cohort. In
addition, another common dTMPK haplotype provided significant protection against
AZT-induced adipocyte mtDNA depletion in a pilot study of AZT- and d4T-treated
individuals. The dTMPK haplotypes characterised in this thesis should facilitate
further studies regarding dTMPK genetic variation in HIV-1 infection and response
to treatment, which are warranted from the clinical results presented herein.
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Dodel, Stefan. "Eine empirische Analyse der Determinanten von Credit Default Swaps und Credit Spreads." St. Gallen, 2007. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/01665546002/$FILE/01665546002.pdf.
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Tralhão, Sandra Isabel Correia Serafim. "Consumo e encargos : percepção VS realidade : o caso dos consumidores." Master's thesis, FEUC, 2011. http://hdl.handle.net/10316/17801.
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Trabalho de projecto do mestrado em Economia Local, apresentado à Faculdade de Economia da Universidade de Coimbra sob a orientação de Eduardo Barata e Rita Martins.<br>A água é um recurso estratégico para o desenvolvimento económico e social da Humanidade. Neste contexto, as restrições naturais dos recursos hídricos implicam, como aspecto fundamental, a promoção de ganhos de eficiência nos usos. A literatura sugere que as políticas de fomento da utilização racional da água devem ser alicerçadas na caracterização dos consumidores, nos usos que estes fazem do recurso e na determinação dos factores que implicam diferentes intensidades de consumo.
Este projecto de investigação, desenvolvido em colaboração com a Águas de Coimbra, E.E.M. (AdC), incide sobre os utilizadores domésticos de água visando, nomeadamente, identificar factores pessoais ou situacionais potencialmente determinantes dos respectivos consumos. A metodologia seguida envolve a recolha de dados primários com elevado nível de detalhe e desagregação, através de aplicação de inquérito por questionário concebido especificamente para este projecto, bem como a recolha de registos de consumo e de facturação efectiva dos clientes inquiridos, com o propósito de permitir o confronto entre os consumos e encargos percepcionados e efectivamente realizados.
A análise da informação empírica recolhida permite identificar factores determinantes do consumo coincidentes com algumas propostas tradicionalmente apresentadas na literatura. Nomeadamente, o estudo da influência da percepção no consumo, enquanto factor pessoal e intrínseco ao indivíduo, sugere que a percepção que os consumidores têm dos encargos é mais próxima da realidade do que a percepção que têm do consumo efectivo. Para além disto, o afastamento entre percepções e realidade no que toca ao consumo aumenta à medida que o consumo aumenta.
O carácter inovador da estratégia de investigação adoptada, o elevado nível de fiabilidade associado aos dados e a reflexão acerca da correspondência, ou não, entre percepções de consumo e consumos efectivos, justificam a expectativa de que este trabalho possa contribuir para aprofundar o debate sobre uma dimensão da procura residencial de água em Portugal, ainda pouco explorada.
As conclusões alcançadas colocam a tónica na necessidade de sensibilização dos consumidores para a utilização racional da água e no papel que as entidades gestoras podem ter no desenvolvimento de acções que permitam aumentar a percepção do seu valor.
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Hood, James Michael. "How to be determinate about indeterminate location." Thesis, University of Exeter, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445449.
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Williams, K. A. "Determinacy and mode interaction in elastic systems." Thesis, Imperial College London, 1985. http://hdl.handle.net/10044/1/37898.
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Cramme, Carsten. "Informationsverhalten als Determinante organisationaler Entscheidungseffizienz." München und Mering Hampp, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2629443&prov=M&dokv̲ar=1&doke̲xt=htm.
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Savitraz, Marcos. "DETERMINANTE DE ALGUMAS MATRIZES ESPECIAIS." Universidade Federal da Grande Dourados, 2015. http://tede.ufgd.edu.br:8080/tede/handle/tede/306.
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Previous issue date: 2015-10-07<br>This work brings an introductory context on determinants of special matrices, specifically the Vandermonde matrix, Cauchy and Hilbert. A compact algebraic formula is deduced for the determinant of each matrix. This formula provides ease in determining in the calculation process for this class of matrices. Applications are considered in the resolution of linear systems as well as in polynomial interpolation. Finally, we propose a class where we discuss concepts cited in the resolution of a problem situation, to be worked with high school students.<br>O presente trabalho nos traz um contexto introdutório sobre determinantes de matrizes especiais, mais concretamente a matriz de Vandermonde, Cauchy e Hilbert. Uma fórmula algébrica compacta é deduzida para o determinante de cada matriz. Esta fórmula nos proporciona facilidade no processo de cálculo do determinante para esta classe de matrizes. Aplicações são consideradas na resolução de sistemas lineares como também na interpolação polinomial. Finalmente, apresentamos uma proposta de aula onde abordamos conceitos citados na resolução de uma situação problema, para ser trabalhada com alunos do Ensino Médio.
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Kunc, Dominik. "Analýza determinant vývoje spotřeby elektřiny." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2013. http://www.nusl.cz/ntk/nusl-220163.
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The aim of this thesis is to briefly introduce the reader to the problem of development of the electricity consumption, to show the possibilities of its prediction, and provide an example of electricity consumption analysis, which may serve as a basis for long-term forecast. The first part of this work is devoted to brief overview of the development of consumption of electrical energy in the Czech Republic and factors associated with that development. The main events of Czech electrification history are outlined, as well as factors influencing the magnitude of the demand for electricity in the recent times. There are described the possibilities of the influence of foreign exchange and price of the electricity, net losses, GDP, the consumption of gas, the number of inhabitants, or the structure of the economy. This work further describes the development of the consumption of electric energy abroad and comparison of the electricity consumption in the Czech Republic to its neighboring countries, in which there are apparently influence by variety of factors that affect the consumption development trend. For more complex overview, the electricity consumption of most of European states is being noted, and near the end of the chapter the development in poorest countries and in quickly growing economies is shown. The fourth chapter mentions methods for short and middle-term prediction of consumption of electricity. There also is more consistent description of possibilities useful for long-term prediction, for which the use of the results of statistics analysis is possible. The description of observed data that are used to find the dependences of different factors is made in the following part. Further the approach of the statistics analysis used in this thesis is shown, and the key terms are explained. The dates concerning the consumption of Czech Republic are analyzed, followed by the states with similar trend of the consumption and finally other European states. Sixth chapter examines the possible uses of the outcomes of statistical analyses for long-term prediction of electricity consumption. The conclusion sums up the knowledge acquired during the research concerning problem of electricity consumption and my own analysis of data.
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Reuss, Thomas. "The determinant method and applications." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:5b49acc6-bc16-45bf-972a-6dff1977db02.
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The thesis is structured into 5 chapters as follows: <strong>Chapter 1</strong> is an introduction to the tools and methods we use most frequently. <strong>Chapter 2</strong> Pairs of k-free Numbers, consecutive square-full Numbers. In this chapter, we refine the approximate determinant method by Heath-Brown. We present applications to asymptotic formulas for consecutive k-free integers, and more generally for k-free integers represented by r-tuples of linear forms. We also show how the method can be used to derive an upper bound for the number of consecutive square-full integers. Finally, we apply the method to make a statement about the size of the fundamental solution of Pell equations. <strong>Chapter 3</strong> Power-Free Values of Polynomials. A conjecture by Erdös states that for any irreducible polynomial f of degree d≥3 with no fixed (d-1)-th power prime divisor, there are infinfinitely many primes p such that f(p) is (d-1)-free. We prove this conjecture and derive the corresponding asymptotic formulas. <strong>Chapter 4</strong> Integer Points on Bilinear and Trilinear Equations. In the fourth chapter, we derive upper bounds for the number of integer solutions on bilinear or trilinear forms. <strong>Chapter 5</strong> In the fifth chapter, we present a method to count the monomials that occur in the projective determinant method when the method is applied to cubic varieties.
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Araujo, Elismar Jose de. "Aplicacao de determinante: area de poligono convexo e volume de piramide." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/4728.
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Previous issue date: 2015-06-17<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>This work will concentrate on making a rereading of the theories that surround the
procedures for calculating the area of a convex polygon, as well as the volume of a
pyramid whose base is a polygon convex, with its vertices properly represented in a
coordinate system, in the plan or in space, respectively. Addresses some topics on arrays
and determinant and some of its applications, in particular the study of polygon area
and the volume of the pyramid. Based on applying a decisive factor for the calculation
of the area of a triangle with its vertices represented in a coordinate system, presents
a new theorem to calculate the area of any polygon convex, as well as, a new formula
to calculate the volume of any pyramid with convex basis as a direct application of the
volume of the tetrahedron with its vertices represented in an orthogonal system. For
both, it was essential to the concept of coordinates in the plane and in space, vectors in
the plane and in space, and some of its properties, being essential for the demonstrate
the volume of the tetrahedron and the area of the triangle, using determinant.
Keywords: Volume. Area. Convex polygon. Pyramid. Triangle. Tetrahedron<br>O presente trabalho versar a em fazer uma releitura das teorias que circundam os
procedimentos de c alculo da area de um pol gono convexo, assim como, do volume de
uma pir^amide cuja base e um pol gono convexo, com seus v ertices devidamente representados
em um sistema de coordenadas, no plano ou no espa co, respectivamente.
Aborda alguns t opicos sobre matrizes e determinante e algumas de suas aplica c~oes, em
especial o estudo de area de pol gonos e o volume de pir^amide. Baseado na aplica c~ao
de determinante para o c alculo da area de um tri^angulo com seus v ertices representados
em um sistema de coordenadas, apresenta um novo teorema para o c alculo da
area de qualquer pol gono convexo, assim como, uma nova f ormula para calcular o volume
de qualquer pir^amide com base convexa como uma aplica c~ao direta do volume do
tetraedro com seus v ertices representados em um sistema ortogonal. Para tanto, foi imprescind
vel abordar o conceito de coordenadas no plano e no espa co, vetores no plano
e no espa co e algumas de suas propriedades, sendo fundamentais para a demonstrar o
volume do tetraedro e a area do tri^angulo, usando determinante.
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Santos, Elisandro Oliveira dos. "Perfil bioquímico-hematológico em lhamas (Lama glama linnaeus 1758) criadas em cativeiro no sul do Brasil: variações de gênero e época do ano." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2006. http://hdl.handle.net/10183/8419.
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As lhamas são camelídeos sul-americanos encontrados em criações zoológicas no Brasil, com grande adaptação a diferentes regiões do mundo. Devido às variações que ocorrem em decorrência da influência da região, nutrição e resposta individual dos animais, é importante caracterizar seus parâmetros fisiológicos para estabelecer valores de referência da espécie. O objetivo do presente trabalho foi estudar valores hematológicos e bioquímicos de lhamas, de um zoológico localizado no município de Gravataí, Rio Grande do Sul, Brasil, avaliando também possíveis diferenças entre sexo e períodos do ano. Os resultados obtidos foram comparados com aqueles descritos na literatura, objetivando contribuir para a compreensão dos mecanismos que afetam sua adaptação na região. Foram utilizadas 16 lhamas clinicamente saudáveis, 8 machos e 8 fêmeas, na faixa etária de 1 a 6 anos de idade. Foram realizadas 8 coletas de sangue para cada sexo através de venipunção jugular, durante o período de um ano. Na comparação entre os sexos, observaram-se diferenças significativas de leucócitos, CK, AST, colesterol, creatinina, frutosamina, glicose, triglicerídeos, albumina, globulinas e fósforo. Em relação a época do ano, houve diferenças significativas entre hemoglobina, triglicerídeos, frutosamina, colesterol, creatinina, proteínas plasmáticas totais, albumina, globulinas, glicose, nas enzimas ALT, AST, LDH e CK, e nos níveis de cálcio e fósforo entre alguns meses. Comparando-se os valores encontrados com a literatura, os níveis de triglicerídeos, globulinas, CK, LDH, uréia e fósforo foram elevados, além de magnésio que mostrou-se mais alto nas fêmeas, enquanto os demais metabólitos tiveram valores similares. Os resultados encontrados mostraram que as lhamas possuem diferentes maneiras de responderem ao manejo, adaptando-se a situações novas num ambiente em constante transformação. Os valores encontrados podem servir como valores de referência para lhamas criadas no sul do Brasil.<br>Llamas are south American camelids found in zoological parks from Brazil, and are adaptable in different world conditions. Due the influence of the region (mainly climate and altitude), nutrition and individual animal responses, it is important to characterize physiological parameters for establishing reference values for this species. The objective of this study was to establish reference values for llamas on zoo conditions from Gravataí, southern Brazil, by evaluating the biochemical and hematological profiles among sex and seasons. Sixteen clinically healthy llamas (eight males and eight females), aged one to six years-Old were used in this trial. Eight blood collections were performed for each animal through jugular venipuncture, along one year. In the comparison between sex, significant differences were observed in leukocites, CK, AST, cholesterol, creatinine, fructosamine, glucose, tryglycerides, albumin, globulin and phosphorus. Regarding the year period, statistical difference was founded in the hemoglobin, tryglycerides, fructosamine, cholesterol, creatinine, total protein, albumin, globulin and, glucose, as well as in enzymes ALT, AST, LDH, CK, and calcium and phosphorus level. Compare with data from literature, the found values for tryglycerides, globulin, CK, LDH, urea and P were higher, and Mg exhibit higher values in females. Other metabolic data were similar to literature report. The results showed that llamas have different ways of responsing to husbandry, situations in an environment of constant transformations. On this basis, the results can be useful as reference values for llamas maintained in the south of Brazil.
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Winter, Brian D. "Determinate migratory behavior of steelhead (Oncorhynchus mykiss) parr. /." Thesis, Connect to this title online; UW restricted, 1992. http://hdl.handle.net/1773/5339.
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Lloyd, Emma Jane. "Determinacy, indeterminacy and collaboration in contemporary music-making." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31382.
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This thesis is structured around three key phases in the process of collaborative music-making - composition, preparation, and performance - examining the function of indeterminacy at each stage, and the way in which musical factors are determined. At what point in the creative process a musical decision is made, the path chosen, and critically, by whom the decision is taken, are all explored in the context of a portfolio of pieces performed and recorded as part of this practice-led research. The portfolio comprises recordings of projects undertaken with composers, as well as pre-existing repertoire, and the written commentary explores my creative role as a performer in relation to that of the composers and the other performers I have worked with. Practical issues faced in collaboration, practice, and performance are dealt with, as are questions of musicality, and the notion of success in musical performance.
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Santos, Leandro Valerim dos. "Produtividade e qualidade de híbridos de tomateiro do segmento salada de crescimento semideterminado em função de sistemas de poda e espaçamento." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/11/11136/tde-02012018-122554/.
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Atualmente a tomaticultura brasileira ostenta o título de cultivo com o maior custo de produção médio no país. Dentre algumas alternativas a fim de minimizar os elevados gastos está o uso de híbridos de crescimento semideterminado em sistema de meia-estaca, devido a menor necessidade de podas, insumos e mão de obra. Realizaram-se dois experimentos, em condições de campo aberto, com os objetivos de (a) determinar o efeito de diferentes sistemas de poda (P1, P2 e P3) e distintos espaçamentos entre plantas (E1 e E2) sobre a produção e seus componentes para o híbrido Silvety, de hábito de crescimento semideterminado do segmento Salada Longa Vida (SLV) (Experimento 1); e (b) avaliar o efeito de distintos sistemas de poda (P1 e P2) sobre a produção e seus componentes para os híbridos Silvety, Sagatan e H003, de hábito de crescimento semideterminado do segmento SLV (Experimento 2). Em ambos os experimentos adotou-se o delineamento em blocos ao acaso com os tratamentos em esquema fatorial 3 x 2 e quatro repetições. O experimento 1 foi conduzido em Jacuí, MG, de maio de 2015 a novembro de 2015, já o experimento 2 foi conduzido em Holambra, SP, de fevereiro de 2016 a agosto de 2016. Avaliaram-se o número total de frutos (NTF), a produção total por parcela (PTP), o número de frutos comercializáveis (NFC), a produção comercial (PCO), a produção por planta (PPP), a massa média dos frutos (MMF), o número de frutos por classe AAA, AA e A (NAAA, NAA e NA), a massa de frutos por classe AAA, AA e A (MAAA, MAA e MA), o número de hastes (NH) o número de inflorescências (NI), o número de frutos por inflorescência (NFI), o número de frutos com rachaduras cuticulares (CUT), o número de frutos ocos (OCO) e o número de frutos manchados (MAN). Nas condições em que os experimentos foram conduzidos e de acordo com os resultados obtidos conclui-se que no experimento 1, a poda P2e o espaçamento E1 mostraram-se os mais indicados para o híbrido Silvety. No experimento 2, novamente, a poda P2 mostrou ser a mais recomendada para os híbridos Silvety, Sagatan e H003.<br>Currently, the Brazilian tomato crop holds the title with the highest average cost of production in the country. Among the alternatives to minimize the high expenses, is the use of hybrids with semi-determinate growth habit in a training system of \"half-stakes\", due to the less need of pruning, inputs and labor. Two experiments were carried out under open field conditions, aiming to (a) to determine the effect of different pruning system (P1, P2 and P3) and spacing between plants (E1 and E2) on the production and its components for the Silvety hybrid, of semi-determinate growth habit of varietal segment Salad Extended Shelf Life (SLV) (Experiment 1), and (b) to evaluate the effect of pruning system (P1 and P2) on the production and its components for the Silvety, Sagatan and H003 hybrids, of semi- determinate growth habit of segment SLV (Experiment 2). In both experiments it was adopted the randomized block design with the treatments in a 3 x 2 factorial scheme, and four replications. Experiment 1 was conducted in Jacuí, MG, from May 2015 to November 2015, and Experiment 2 was conducted in Holambra, SP, from February 2016 to August 2016. There were assessed the total number of fruits (NTF), the total production per plot (PTP), the number of commercial fruits (NFC), the commercial production (PCO), the production per plant (PPP), the average mass of fruits (MMF), the number of fruits per classes AAA,AA and A (NAAA, NAA and NA), the mass of fruits per classes AAA, AA and A (MAAA, MAA and MA), the number of stems (NH), the number of clusters (NI), number of fruits per cluster (NFI), number of fruits with micro-cracking (CUT), number of hollow fruits (OCO), number of fruits with blotchy (MAN). Under the conditions that the trials were conducted and according to the results obtained, it was concluded that in experiment 1, the pruning system P2 and E1 spacing were the most suitable for Silvety hybrid. In experiment 2, again, the pruning system P2 showed to be the most recommended for Silvety, Sagatan and H003 hybrids.
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Hagen, Thomas Ch. "Elongational Flows in Polymer Processing." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/29437.
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The production of long, thin polymeric fibers is a main objective of the textile industry. Melt-spinning is a particularly simple and effective technique. In this work, we shall discuss the equations of melt-spinning in viscous and viscoelastic flow. These quasilinear hyperbolic equations model the uniaxial extension of a fluid thread before its solidification.
We will address the following topics: first we shall prove existence, uniqueness, and regularity of solutions. Our solution strategy will be developed in detail for the viscous case. For non-Newtonian and isothermal flows, we shall outline the general ideas. Our solution technique consists of energy estimates and fixed-point arguments in appropriate Banach spaces. The existence result for a simple transport equation is the key to understanding the quasilinear case. The second issue of this exposition will be the stability of the unforced frost line formation. We will give a rigorous justification that, in the viscous regime, the linearized equations obey the ``Principle of Linear Stability''. As a consequence, we are allowed to relate the stability of the associated strongly continuous semigroup to the numerical resolution of the spectrum of its generator. By using a spectral collocation method, we shall derive numerical results on the eigenvalue distribution, thereby confirming prior results on the stability of the steady-state solution.<br>Ph. D.
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De, Gaetano Giovanni. "A regularized arithmetic Riemann-Roch theorem via metric degeneration." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19227.
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Das Hauptresultat dieser Arbeit ist ein regularisierter arithmetischer Satz von Riemann-Roch für ein hermitesches Geradenbündel, die isometrisch zum Geradenbündel den Spitzenformen vom geraden Gewicht ist, auf eine arithmetische Fläche, deren komplexe Faser isometrisch zu einer hyperbolischen Riemannschen Fläche ohne elliptische Punkte ist.
Der Beweis des Resultats erfolgt durch metrische Degeneration: Wir regularisieren die betreffenden Metriken in einer Umgebung der Singularitäten, wenden dann den arithmetischen Riemann-Roch-Satz von Gillet und Soulé an und lassen schließlich den Parameter gegen Null gehen. Durch die metrische Degeneration entsteht auf beiden Seiten der Formel ein divergenter Term. Die asymptotische Entwicklung der Divergenz berechnet sich auf der einen Seite direkt aus der Definition der glatten arithmetischen Selbstschnittzahlen.
Der divergente Term auf der anderen Seite ist die zeta-regularisierte Determinante des zu den regularisierten Metriken assoziierten Laplace-Operators, der auf den 1-Formen mit Werten in dem betrachteten hermitischen Geradenbündel operiert. Wir definieren und berechnen zuerst eine Regularisiereung des entsprechenden zu den singulären Metriken assoziierten Laplace-Operators; diese wird später im regularisierten Riemann-Roch-Satz auftauchen. Zu diesem Zweck passen wir Ideen von Jorgenson-Lundelius, D'Hoker-Phong und Sarnak auf die vorliegende Situation an und verallgemeinern diese.
Schließlich beweisen wir eine Formel für den zum betrachteten hermitischen Geradenbündel assoziierten Wärmeleitungskern auf der Diagonalen bei einer Modellspitze. Diese Darstellung steht im Zusammenhang mit einer Entwicklung nach zur Whittaker-Gleichung assoziierten Eigenfunktionen, die im Anhang bewiesen wird. Weitere Abschätzungen des zum betrachteten hermitischen Geradenbündel gehörigen Wärmeleitungskern auf der komplexe Faser der arithmetischen Fläche schließen den Beweis des Hauptresultats ab.<br>The main result of the dissertation is an arithmetic Riemann-Roch theorem for the hermitian line bundle of cusp form of given even integer weights on an arithmetic surface whose complex fiber is isometric to an hyperbolic Riemann surface without elliptic points.
The proof proceeds by metric degeneration: We regularize the metric under consideration in a neighborhood of the singularities, then we apply the arithmetic Riemann-Roch theorem of Gillet and Soulé, and finally we let the parameter go to zero. Both sides of the formula blow up through metric degeneration. On one side the exact asymptotic expansion is computed from the definition of the smooth arithmetic intersection numbers.
The divergent term on the other side is the zeta-regularized determinant of the Laplacian acting on 1-forms with values in the chosen hermitian line bundle associated to the regularized metrics. We first define and compute a regularization of the determinant of the corresponding Laplacian associated to the singular metrics, which will later occur int he regularized arithmetic Riemann-Roch theorem. To do so we adapt and generalize ideas od Jorgenson-Lundelius, D'Hoker-Phong, and Sarnak.
Then, we prove a formula for the on-diagonal heat kernel associated to the chosen hermitian line bundle on a model cusp, from which its behavior close to a cusp is transparent. This expression is related to an expansion in terms of eigenfunctions associated to the Whittaker equation, which we prove in an appendix. Further estimates on the heat kernel associated to the chosen hermitian line bundle on the complex fiber of the arithmetic surface prove the main theorem.
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Palomo, Gálvez Marta. "Determinació de radionúclids en mostres ambientals." Doctoral thesis, Universitat Rovira i Virgili, 2010. http://hdl.handle.net/10803/9053.
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L'objectiu principal d'aquesta tesi és el desenvolupament de mètodes analítics que permetin la determinació dels paràmetres establerts per la normativa, per aigües destinades al consum humà (índexs d'activitat alfa total i beta total i activitat de triti) així com, la caracterització d'un grup d'emissors gamma i els isòtops de l'urani i el tori, tant en mostres aquoses com en mostres sòlides. <br/><br/>Per altra banda, a part del desenvolupament d'aquests mètodes, s'ha realitzat la caracterització d'aigües superficials, aigües embotellades, sediments, fangs i biota. Els treballs realitzats es troben, principalment, localitzats a l'últim tram de la conca del riu Ebre per avaluar la possible influència de les indústries localitzades en aquesta zona. Concretament, en aquest tram del riu Ebre es troben localitzades la central nuclear d'Ascó, la indústria de fosfat bicàlcic i finalment, la planta de tractament d'aigua potable a l'Ampolla. Aquestes indústries degut al seu funcionament, poden incrementar la presència de radionúclids tant d'origen natural com artificial en els diferents ecosistemes d'aquest riu.<br>El objetivo principal de esta tesis es el desarrollo de métodos analíticos que permitan la determinación de los parámetros establecidos por la normativa, para aguas destinadas al consumo humano (índices de actividad alfa total i beta total i actividad de tritio) así como, un grupo de emisores gamma i los isótopos del uranio y el torio, en muestras acuosas y en muestras sólidas. <br/><br/>Por otro lado, a parte del desarrollo de estos métodos, se ha realizado la caracterización de aguas superficiales, aguas embotelladas, sedimentos, lodos y biota. Los trabajos realizados se encuentran principalmente localizados en el último tramo del río Ebro con la finalidad de evaluar la posible influencia de las industrias localizadas en esta zona. Concretamente, en este tramo del río Ebro se encuentran localizadas la central nuclear de Ascó, la industria de fosfato bicálcico y finalmente, la planta de tratamiento de agua potable en la Ampolla. Estas industrias debido a su funcionamiento, pueden incrementar la presencia de radionucleidos tanto de origen natural como artificial en los diferentes ecosistemas de este río.
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Nemani, Neeharika. "Molecular Determinant of Mitochondrial Shape Change." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/511170.
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Biomedical Sciences<br>Ph.D.<br>Mitochondria shape cytosolic Ca2+ (cCa2+) transients. Ca2+ entry into the mitochondria is driven by the highly negative mitochondrial membrane potential and through a highly selective channel, the Mitochondrial Calcium Uniporter (MCU). Mitochondrial Ca2+ (mCa2+) is utilized by the matrix dehydrogenases for maintaining cellular bioenergetics. The TCA cycle-derived NADH and FADH2 are mCa2+ dependent thus, feed into the electron transport chain (ETC) to generate ATP. Either loss of mCa2+ or metabolite uptake by the mitochondria results in a bioenergetic crisis and mitochondrial dysfunction. Reciprocally, sudden elevation of cCa2+ under conditions of stroke or ischemia/reperfusion injury (I/R) drives excessive mCa2+ overload that in turn leads to the opening of a large channel, the mitochondrial permeability transition pore (PTP) that triggers necrotic cell death. Thus, Ca2+ and metabolite equilibrium is essential to maintain a healthy mitochondrial pool. Our laboratory has previously showed that loss of mCa2+ uptake leads to decreased ATP generation and cell survival through autophagy. Although metabolite scarcity also results in similar reduction in ATP generation, the molecular mechanisms by which metabolites control mitochondrial ion homeostasis remain elusive. Deprivation of glucose or supplementation of mitochondrial pyruvate carrier (MPC) transport blocker UK5099 and or carnitine-dependent fatty acid blocker etomoxir triggered an increase in the expression of MICU1, a regulator of the mitochondrial calcium uniporter (MCU) but not the MCU core subunit. Consistently, either RNAi-mediated deletion of MPC isoforms or dominant negative human mutant MPC1 R97W showed significant induction of MICU1 protein abundance and inhibition of MCU-mediated mCa2+ uptake. Moreover, TCA cycle substrate-dependent MICU1 expression is under the control of EGR1 transcriptional regulation. Reciprocally, the MICU1 dependent inhibition of mCa2+ uptake exhibited lower NADH production and oxygen consumption and ATP production. The reduction of mitochondrial pyruvate by MPC knockdown is linked to higher production of mitochondrial ROS and elevated autophagy markers. These studies reveal an unexpected regulation of MCU-mediated mCa2+ flux machinery involving major TCA cycle substrate availability and possibly MICU1 to control cellular switch between glycolysis and oxidative phosphorylation. While mCa2+ is required for energy generation, sustained elevation of mCa2+ results in mitochondrial swelling and necrotic death. Hence, it was thought that preventing mCa2+ overload can be protective under conditions of elevated cCa2+. Contrary to this, mice knocked-out for MCU, that demonstrated no mCa2+ uptake and hence no mitochondrial swelling, however failed protect cells from I/R- mediated cell death. MCU-/- animals showed a similar infarct size comparable to that of control animals, suggesting that prevention of MCU-mediated mCa2+ overload alone is not sufficient to protect cells from Ca2+ -induced necrosis. The absence of mCa2+ entry revealed an elevation in the upstream cCa2+ transients in hepatocytes from MCUDHEP. Ultra-structural analysis of liver sections from MCU-/- (MCUDHEP) and MCUfl/fl animals revealed stark contrast in the shape of mitochondria: MCUfl/fl liver sections showed long and filamentous mitochondria (spaghetti-like) while MCUDHEP mitochondria were short and circular (donut-like). Furthermore, challenging MCUfl/fl and MCUDHEP hepatocytes with ionomycin caused a marked increase in cCa2+ and a simultaneous change in mitochondrial shape (from spaghetti to donut), a phenomenon we termed mitochondrial shape transition (MiST) that was independent of mitochondrial swelling. The cCa2+-mediated MiST is induced by an evolutionarily conserved mitochondrial surface EF-hand domain containing Miro1. Glutamate and Ca2+ -stress driven cCa2+ mobilization cause MiST in neurons that is suppressed by expression of Miro1 EF1 mutants. Miro1-dependent MiST is essential for autophagosome formation that is attenuated in cells harboring Miro1 EF1 mutants. Remarkably, loss of cCa2+ sensitization by Miro1 prevented MiST and mitigated autophagy. These results demonstrate that an interplay of ions and metabolites function in concert to regulate mitochondrial shape that in turn dictates the diverse mitochondrial processes from ATP generation to determining mechanisms of cell death.<br>Temple University--Theses
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CARVALHO, GILBERTO. "Determinacao de defeitos em profundidade (estereoradiografia)." reponame:Repositório Institucional do IPEN, 2001. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10938.
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