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1

Cookenboo, H. O., and R. M. Bustin. "Jura-Cretaceous (Oxfordian to Cenomanian) stratigraphy of the north-central Bowser Basin, northern British Columbia." Canadian Journal of Earth Sciences 26, no. 5 (1989): 1001–12. http://dx.doi.org/10.1139/e89-081.

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Three new formations of Late Jurassic and Early to mid-Cretaceous age are defined for a 2000 m thick section of Jura-Cretaceous rocks exposed in the north-central Bowser Basin. The Currier Formation (Oxfordian to Kimmeridgian or Tithonian) consists of 350–600 m of interbedded shales, siltstones, sandstones, coals, and carbonates. The McEvoy Formation (Barremian to as young as Albian) consists of 400–800 m of siltstones and shales with minor sandstones, thin coals, limestones, and conglomerates. The Devils Claw Formation (in part mid-Albian to Cenomanian) consists of 300–600 m of strata characterized by thick pebble and cobble conglomerates, with associated coarse sandstones and minor siltstones and shales.Two successive coarsening-upward sequences are identified in the study area. The first begins with Middle Jurassic marine shales of the Jackson unit grading upwards to coarser Upper Jurassic facies of the Currier Formation. The Currier Formation is conformably or unconformably overlain by siltstones and shales of the Lower Cretaceous McEvoy Formation, which forms the base of a second coarsening-upward sequence. Conglomerates appear with increasing frequency in the upper McEvoy and are the dominant lithology of the overlying Devils Claw Formation. The contact between the McEvoy and Devils Claw formations is gradational. The Devils Claw Formation forms the top of the second coarsening-upward sequence.The Currier Formation (Late Jurassic) is equivalent to the upper units of the Bowser Lake Group. The McEvoy and the Devils Claw formations (Barremian to Cenomanian) are coeval with the Skeena Group (Hauterivian? to Cenomanian). A probable unconformity separating the Upper Jurassic Currier Formation from the Lower Cretaceous McEvoy Formation correlates with a hiatus in the southern Bowser Basin and probably represents a regional unconformity.
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2

MacLeod, S. E., and L. V. Hills. "Conformable Late Jurassic (Oxfordian) to Early Cretaceous strata, northern Bowser Basin, British Columbia: a sedimentological and paleontological model." Canadian Journal of Earth Sciences 27, no. 7 (1990): 988–98. http://dx.doi.org/10.1139/e90-101.

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The upper Jackson unit in the northern Bowser Basin includes marine strata of Late Jurassic (middle Oxfordian to Tithonian) age on the basis of the presence of Vaugonia doroschini (Eichwald), Buchia concentrica (Sowerby), Buchia mosquensis (Von Buch), Buchia piochii (Gabb), and Buchia fischeriana (d'Orbigny). Herzogina Chavan and plant macrofossils in the overlying Currier Formation indicate an Early Cretaceous age. Macrofloras of the overlying McEvoy and Devils Claw formations are most similar to Early Cretaceous, pre-Albian floras of the Western Interior Basin of North America.A model of continuous sedimentation from the Jurassic to Early Cretaceous time is proposed, with a progression from marine conditions of the Jackson unit to marginal marine conditions, with lower delta plant deposition in the Currier Formation, to nonmarine fluvial conditions, with upper delta plain deposition in the McEvoy Formation. This stratigraphic sequence culminated in alluvial deposits of the Devils Claw Formation.The present evidence indicates uninterrupted deposition from the Jackson unit to the Devils Claw Formation.
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3

Pennisi, Elizabeth. "Tasmanian devils claw their way back from extinction." Science 370, no. 6522 (2020): 1257. http://dx.doi.org/10.1126/science.370.6522.1257.

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4

Moffat, I. W., R. M. Bustin, and G. E. Rouse. "Biochronology of selected Bowser Basin strata; tectonic significance." Canadian Journal of Earth Sciences 25, no. 10 (1988): 1571–78. http://dx.doi.org/10.1139/e88-150.

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Recent evaluation and reinterpretation of fossil floral and faunal data more clearly define the ages of strata exposed in the Groundhog Coalfield and the surrounding Bowser Basin of north-central British Columbia. In the Groundhog Coalfield, Bowser Lake Group strata consist of an overall coarsening-upwards cycle divisible into four informal stratigraphic units, which are, from oldest to youngest, the Jackson, Currier, McEvoy, and Devils Claw units. The section has an unconformable relationship with underlying Bajocian Spatsizi marine shales, volcanics, and arenaceous sediments. Marine macrofossils indicate a Callovian to Oxfordian age for the Jackson unit. The fossil plant succession present in the overlying Currier unit indicates Late Jurassic affinities. Recent unpublished palynologic data from lower McEvoy rocks in the northern Groundhog Coalfield suggest a Barremian age. The palynoassemblage present in the lower Devils Claw unit in the central part of the Groundhog Coalfield suggests a late middle Albian age.Rocks of the Sustut Group have an angular unconformable relationship with underlying Bowser Lake Group strata near the eastern margin of the Bowser Basin. The palynoassemblage present in Sustut Group rocks from the southern Sustut Basin suggests a Campanian to Maastrichtian age range, in contrast to a probable late Albian to Campanian age range for the northern Sustut Basin and a middle to late Albian age from Sustut Group outliers present within the northern Bowser Basin. Within the Groundhog Coalfield, Devils Claw strata have a conformable or paraconformable relationship with underlying Bowser Lake Group strata.Regional discrepancy in the age and geometry of the sub-Sustut unconformity is attributed to a time-transgressive unconformity that resulted from cratonward advance of an isostatically induced peripheral bulge. Age and contact relationships suggest that deformation in the Bowser Basin and surrounding Sustut Basin must have spanned the time period that corresponds to a second uplift pulse of the Columbian orogen (Aptian to early Cenomanian) and the uplift pulse related to the Laramide orogen (Campanian to Maastrichtian).
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5

Goetze, Karlie, and Derek Sandow. "Removing the Devils Claw from Gregory National Park, Northern Territory." Australasian Plant Conservation: journal of the Australian Network for Plant Conservation 18, no. 4 (2010): 19–20. http://dx.doi.org/10.5962/p.373300.

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6

Nalluri, Buchi N., and S. Sujithkumar. "Characterization and Estimation of Harpagoside in Dried Root Extract and Oral Powder Formulations of Harpagophytum Procumbens by Validated RP-HPLC-PDA Method." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 38–46. http://dx.doi.org/10.22270/jddt.v9i2.2459.

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The present investigation was undertaken to perform structural, physicochemical characterization and to estimate the harpagoside in dried root extract and flavoured powder formulations of harpagophytum procumbens (devils claw). The extraction of harpagoside from the root extract was carried out using different solvents and the harpagoside content was estimated using an RP-HPLC-PDA method. The HPLC analysis was carried out using methanol: 0.02% formic acid (60:40 v/v) as the mobile phase, pumped at flow rate of 1mL/min through C18 column (Kinetex XB, 150x4.6mm, 5µ). The structural and physicochemical characterization of the root extract was performed using FT-IR, DSC and SEM analysis. Flavoured powder formulations (effervescent and non-effervescent) of the root extract were prepared and the harpagoside content was estimated by HPLC method. Higher percentage of harpagoside (1.6 %) was extracted with water as extraction solvent when compared to methanol and methanol: water (50:50 v/v). The developed RP-HPLC-PDA method resulted in shorter elution time (harpagoside was eluted at 5.3min) and the method was linear with good regression coefficient (R2>0.998) within the concentration range tested (0.2-4µg/mL). The FT-IR spectra of root extract showed the presence of characteristic peaks corresponding to the harpagoside and the results from photomicrographs and SEM analysis revealed spherical morphology of the particles in the extract. The prepared powdered formulations readily dispersed and dissolved in water and showed more than 98% of harpagoside content even after 6months time period indicating the stability of the formulations. Overall, the results from the present investigation can form basis to establish standardization parameters for formulations containing root extract of devil’s claw.
 Keywords: Harpagophytum procumbens, Structural and physicochemical characterization, RP-HPLC-PDA method, FT-IR, DSC, SEM.
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7

Stoffle, Richard, Kathleen Van Vlack, Heather H. Lim, and Alannah Bell. "Mateo Tepe or Devils Tower: Native and Tourist Differences in Geosite Interpretations." Land 13, no. 3 (2024): 357. http://dx.doi.org/10.3390/land13030357.

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Devils Tower is located in Wyoming, USA. It is composed of volcanic elements from the Tertiary Period of geologic time. Geologists are interested in this geosite because it is a unique, upstanding, steep-sided, high-relief exhumed Tertiary-age volcanic plug. As a Native American cultural geosite, however, it is often called Mateo Tepe, and it is a sacred place to over 20 Native American tribes. It was inscribed as America’s first national monument in 1906 by President Theodore Roosevelt, because of its special geology. It is visually dramatic due to its columns, which are understood by earth scientists as a wonder of geology but by Native people as the claw scratches of a spiritual bear. These vertical cracks are the focus of rock climbers and Native people, respectively as opportunities for adventure and self-fulfillment and spiritual paths to another dimension and the achievement of religious balance in the world. Mateo Tepe became a national monument due to it being a unique geologic feature. The geopark concept is used in this analysis to talk about this geologically based monument.
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8

Aurangzeb, Kumar Deepak, and Kumar Singh Sushil. "A Hospital-Based Evaluation of the Therapeutic Effectiveness of Nutraceuticals in Treating Osteoarthritis." International Journal of Toxicological and Pharmacological Research 14, no. 1 (2024): 299–304. https://doi.org/10.5281/zenodo.12707048.

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<strong>Aim:</strong>&nbsp;Assessing the therapeutic effectiveness of nutraceuticals in treating osteoarthritis.&nbsp;<strong>Material and Methods:</strong>&nbsp;The present observational study was conducted at Department of Orthopaedics, Jannayak Karpoori Thakur Medical College and Hospital, Madhepura, Bihar, India. Patients were recruited from Department of Orthopaedics, Jannayak Karpoori Thakur Medical College and Hospital, Madhepura, Bihar, India for 1year. Aged between 19 to 75 years with the clinical diagnosis of osteoarthritis of the knee based on the American College of Rheumatology (ACR) criteria and at least moderate pain in the knee (rated at 5 or greater by the subject on a visual analog scale) during the most painful knee movement during the last month. Patients who had uncontrolled diabetes, hypertension, hepatic disorder, pregnant &amp; lactating women, acute joint trauma of knee were excluded from the study.&nbsp;<strong>Results:</strong>&nbsp;Out of 151 patients, 78% patients had comorbidities such as hypertension, anxiety, diabetes mellitus, thyroid disorders etc. All the subjects selected during the study received TriNyros capsule two times daily for three months. At the baseline the mean WOMAC combined score was 39.62&nbsp;<u>+</u>&nbsp;11.95 (<em>p&lt;&nbsp;</em>0.05) which was reduced significantly to 13.36&nbsp;<u>+&nbsp;</u>4.82 (<em>p&lt;&nbsp;</em>0.05) at the end of study. From the baseline 66.80% improvement observed in the patient after treatment with TriNyros. Further sub-group analysis shows that, total WOMAC score in OA patient with comorbidities reduced from 39.37&nbsp;<u>+</u>&nbsp;11.52 to 13.34&nbsp;<u>+</u>&nbsp;4.48 (<em>p&lt;&nbsp;</em>0.05) &amp; in patient without comorbidities reduced from 40.08&nbsp;<u>+</u>&nbsp;12.82 to 13.40&nbsp;<u>+</u>&nbsp;5.43 (<em>p&lt;&nbsp;</em>0.05) after 90 days treatment with TriNyros.&nbsp; The subgroup analysis revealed that TriNyros reduces pain on palpations significantly from 1.98&nbsp;<u>+</u>&nbsp;0.64 to 0.66&nbsp;<u>+</u>&nbsp;0.52 (63.94%) in OA patient without any other disorder and 2.12&nbsp;<u>+&nbsp;</u>0.63 to 0.77&nbsp;<u>+</u>&nbsp;0.47 (66.67%) (<em>P&lt;&nbsp;</em>0.05) in OA patient with co-morbidities.&nbsp;<strong>Conclusion:</strong> The findings of the current phase IV post marketing surveillance suggest that TriNyros act synergistically to exert anti‐inflammatory/anti‐arthritic activity. Cap TriNyros efficaciously reduces joint pain and improves the physical functional ability of OA patient. Furthermore, Cap. TriNyros shows similar efficacy in OA patients with comorbidity and without comorbidity.
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9

Raja, Anurag Gautam, Vivek Vinit, Ranjan Prity, Kumar Rajak Rajeev, and Singh Saumya. "A Hospital-Based Assessment of the Clinical Efficacy of Nutraceuticals in the Management of Osteoarthritis." International Journal of Current Pharmaceutical Review and Research 16, no. 04 (2024): 740–44. https://doi.org/10.5281/zenodo.12804560.

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AbstractAim: The aim of the present study was to evaluate the marketed product TriNyros (combination of Rosehip, IridoForce TM, Aflapin) (Nutragenix Healthcare Pvt. Ltd.) as an additive treatment in OA patients and its effect inpatients with &amp; without comorbidity.Methods: A phase IV post marketing surveillance study of Cap. TriNyros (Nutragenix Healthcare Pvt. Ltd.) wasconducted at Department of Orthopedics, Government Medical College and Hospital, Bettiah, West Champaran,Bihar, India for six months During the study total 160 patients were selected based on inclusion and exclusioncriteria in which comprises 60 (37.5%) males and 100 (62.5%) females. The mean age of the subject was 58.60years, and 70% patients belong to the age group above 50 years. Out of 160 patients, 75% patients hadcomorbidities such as hypertension, anxiety, diabetes mellitus, thyroid disorders etc. All the subjects selectedduring the study received TriNyros capsule two times daily for three months.Results: During analysis of clinical symptoms parameters such as joint line tendinitis on palpations, limitation ofmobility, joint crepitus, swelling and redness were included in the study. The treatment with TriNyros for 3 monthsleads to 60.64% reduction in pain on palpations of OA patient. Movement of a joint affected by OA may cause acrackling or grating sensation called "crepitus&rdquo;. The reduction rate for joint crepitus is similar in OA patient withcomorbidity (72.65%) &amp; without comorbidity (66.70%).Conclusion: OA as it has an important effect on the treatment. Finally, only one fixed dose of TriNyros was usedduring the study to evaluate its efficacy; hence we could not validate effect of different doses on safety and efficacyin OA patient. The findings of the current phase IV post marketing surveillance suggest that TriNyros (NutragenixHealthcare Pvt. Ltd) act synergistically to exert anti‐inflammatory/anti‐arthritic activity. Cap TriNyrosefficaciously reduces joint pain and improves the physical functional ability of OA patient.
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10

Varun, Kumar. "A Hospital Based Clinical Assessment of the Efficacy of Nutraceuticals in the Management of Osteoarthritis." International Journal of Toxicological and Pharmacological Research 12, no. 9 (2022): 130–36. https://doi.org/10.5281/zenodo.11475768.

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<strong>Aim:&nbsp;</strong>The aim of the present study was to evaluate the marketed product TriNyros (combination of Rosehip, IridoForceTM, Aflapin) (Nutragenix Healthcare Pvt. Ltd.) as an additive treatment in OA patients and its effect in patients with &amp; without comorbidity.&nbsp;<strong>Methods:&nbsp;</strong>A phase IV post marketing surveillance study of Cap. TriNyros (Nutragenix Healthcare Pvt. Ltd.) was conducted at Department of Orthopaedics, Lord Buddha Koshi Medical College &amp; Hospital, Saharsa, Bihar, India for 2 years. During the study total 160 patients were selected based on inclusion and exclusion criteria in which comprises 60 (37.5%) males and 100 (62.5%) females. The mean age of the subject was 58.60 years, and 70% patients belong to the age group above 50 years. Out of 160 patients, 75% patients had comorbidities such as hypertension, anxiety, diabetes mellitus, thyroid disorders etc. All the subjects selected during the study received TriNyros capsule two times daily for three months.&nbsp;<strong>Results:&nbsp;</strong>During analysis of clinical symptoms parameters such as joint line tendinitis on palpations, limitation of mobility, joint crepitus, swelling and redness were included in the study. The treatment with TriNyros for 3 months leads to 60.64% reduction in pain on palpations of OA patient. Movement of a joint affected by OA may cause a crackling or grating sensation called &ldquo;crepitus&rdquo;. The reduction rate for joint crepitus is similar in OA patient with comorbidity (72.65%) &amp; without comorbidity (66.70%).&nbsp;<strong>Conclusion:&nbsp;</strong>OA as it has an important effect on the treatment. Finally, only one fixed dose of TriNyros was used during the study to evaluate its efficacy; hence we could not validate effect of different doses on safety and efficacy in OA patient. The findings of the current phase IV post marketing surveillance suggest that TriNyros (Nutragenix Healthcare Pvt. Ltd) act synergistically to exert anti-inflammatory/anti-arthritic activity. Cap TriNyros efficaciously reduces joint pain and improves the physical functional ability of OA patient.
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11

Sanjay, Kumar Gupta. "Management of Osteoarthritis: Clinical Efficacy of Nutraceuticals." International Journal of Toxicological and Pharmacological Research 12, no. 9 (2022): 229–35. https://doi.org/10.5281/zenodo.11490700.

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<strong>Aim:&nbsp;</strong>The aim of the present study was to evaluate the marketed product TriNyros (combination of Rosehip, IridoForceTM, Aflapin) (Nutragenix Healthcare Pvt. Ltd.) as an additive treatment in OA patients and its effect in patients with &amp; without comorbidity.&nbsp;<strong>Methods:&nbsp;</strong>A phase IV post marketing surveillance study of Cap. TriNyros (Nutragenix Healthcare Pvt. Ltd.) was conducted at Department of Orthopaedics, Shree Narayan Medical Institute &amp; Hospital, Saharsa, Bihar, India for 1.5 years. During the study total 80 patients were selected based on inclusion and exclusion criteria in which comprise 30 (37.5%) males and 50 (62.5%) females. The mean age of the subject was 58.60 years, and 70% patients belong to the age group above 50 years. Out of 80 patients, 75% patients had comorbidities such as hypertension, anxiety, diabetes mellitus, thyroid disorders etc. All the subjects selected during the study received TriNyros capsule two times daily for three months.&nbsp;<strong>Results:&nbsp;</strong>During analysis of clinical symptoms parameters such as joint line tendinitis on palpations, limitation of mobility, joint crepitus, swelling and redness were included in the study. The treatment with TriNyros for 3 months leads to 60.64% reduction in pain on palpations of OA patient. Movement of a joint affected by OA may cause a crackling or grating sensation called &ldquo;crepitus&rdquo;. The reduction rate for joint crepitus is similar in OA patient with comorbidity (72.65%) &amp; without comorbidity (66.70%).&nbsp;<strong>Conclusion:&nbsp;</strong>OA as it has an important effect on the treatment. Finally, only one fixed dose of TriNyros was used during the study to evaluate its efficacy; hence we could not validate effect of different doses on safety and efficacy in OA patient. The findings of the current phase IV post marketing surveillance suggest that TriNyros (Nutragenix Healthcare Pvt. Ltd) act synergistically to exert anti-inflammatory/anti-arthritic activity. Cap TriNyros efficaciously reduces joint pain and improves the physical functional ability of OA patient.
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12

Warren, Josephine, and Brian Martin. "Researching new diseases: assumptions and trajectories." Research Ideas and Outcomes 4 (July 25, 2018): e28578. https://doi.org/10.3897/rio.4.e28578.

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New diseases in humans and animals have been the subject of considerable research as well as policy development and popular attention. Researchers commonly proceed on the basis of plausible assumptions about mechanisms, pathways, and dangers but seldom question the assumptions themselves. Studies in the history and sociology of science show that research trajectories are conditioned by social, political, and economic arrangements. The assumptions underlying research into three new diseases—devil facial tumor disease in Tasmanian devils, AIDS in humans, and leukemia in soft-shell clams—are examined, and dominant and alternative research programs compared. In each case, most research has assumed the disease is spread through "natural processes", while research about possible human influences has been left undone.
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13

Prostko, Eric P., and James M. Chandler. "Devil's-Claw (Proboscidea louisianica) and Smellmelon (Cucumis melovar.dudaim) Control in Cotton (Gossypium hirsutum) with Pyrithiobac." Weed Technology 12, no. 1 (1998): 19–22. http://dx.doi.org/10.1017/s0890037x00042500.

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Devil's-claw and smellmelon are summer annual broadleaf weed problems in the southwest cotton production region. Field studies conducted in 1993 and 1994 evaluated the efficacy of pyrithiobac for postemergence (POST) control of devil's-claw and smellmelon compared with soil-applied fluometuron or prometryn. Pyrithiobac at 0.07 and 0.14 kg ai/ha early POST and 0.14 kg ai/ha mid-POST controlled devil's-claw more than 84% at the late rating. Devil's-claw control with mid-POST applications of pyrithiobac at 0.07 kg ai/ha was reduced when compared with other rates and application timings. Smellmelon control with pyrithiobac ranged from 57 to 84% and, except when applied at 0.07 kg ai/ha early POST, was equivalent to or greater than either fluometuron or prometryn. Crop injury with pyrithiobac treatments 16 d after treatment was 5 to 13%, but 33 d later, was no more than 3%.
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14

Riffle, Michael S., Don S. Murray, John F. Stone, and David L. Weeks. "Soil-Water Relations and Interference Between Devil's-Claw (Proboscidea louisianica) and Cotton (Gossypium hirsutum)." Weed Science 38, no. 1 (1990): 39–44. http://dx.doi.org/10.1017/s0043174500056083.

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Soil water from plots containing cotton, devil's-claw, cotton with devil's-claw, and bare soil was measured throughout the growing season using a neutron probe and related to weed interference with the crop. Volumetric water content throughout the soil profile to a depth of 180 cm did not differ among treatments before the 5th or 6th week after cotton emergence. Greater water depletion occurred early in the season in plots containing devil's-claw which corresponded to a period of rapid weed growth. In plots containing only cotton, the largest reduction in water content occurred later in the season during peak bloom and early boll formation. Soil water content at depths greater than 105 cm remained unchanged in all plots throughout the season. Interference from devil's-claw reduced cotton lint yield 96% in 1986 and 46% in 1987. Higher rainfall and reduced weed populations in 1987 reduced the impact of weed interference on cotton lint yield.
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15

Brendler, Thomas, Joerg Gruenwald, Catherine Ulbricht, and Ethan Basch. "Devil’s Claw (Harpagophytum procumbensDC)." Journal of Herbal Pharmacotherapy 6, no. 1 (2006): 89–126. http://dx.doi.org/10.1080/j157v06n01_09.

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16

Kondamudi, Narasimharao, Matthew W. Turner, and Owen M. McDougal. "Harpagoside Content in Devil's Claw Extracts." Natural Product Communications 11, no. 9 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100903.

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Devil's claw is a common ingredient in nutraceutical products for the treatment of inflammation due to arthritis. The secondary root extract of Harpagophytum procumbens contains bioactive iridoid glycosides known as harpagosides. Recent scrutiny of the nutraceutical industry claims that products listing devil's claw on their labels should refer only to H. procumbens, while the closely related, and less expensive, H. zeyheri is not to be classified as devil's claw. This assertion is in contrast to botanists who claim that either species of Harpagophytum can be generically referred to as devil's claw. The current research aimed to determine the chemical composition of extracts from H. procumbens and H. zeyheri, with the intent to identify whether the bioactive harpagosides were similarly present between species, and how their presence resembled or deviated from commercially available H. procumbens extracts commonly used in nutraceutical products. A microwave extraction followed by high performance liquid chromatography analysis of root samples from botanical specimens of H. procumbens and H. zeyheri identified similar quantities of harpagoside, regardless of species. The chemical composition between root extracts for each species was found to contain varying quantities of non-harpagoside constituents, however their harpagoside content was comparable. These findings are intended to inform policymakers, nutraceutical manufacturers, and the general public of the distinction between myth and reality regarding devil's claw supplements.
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17

Dotray, Peter A., J. Wayne Keeling, C. Gary Henniger, and John R. Abernathy. "Palmer Amaranth (Amaranthus palmeri) and Devil's-claw (Proboscidea louisianica) Control in Cotton (Gossypium hirsutum) with Pyrithiobac." Weed Technology 10, no. 1 (1996): 7–12. http://dx.doi.org/10.1017/s0890037x00045632.

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Field experiments conducted in 1991, 1992, and 1993 evaluated Palmer amaranth and devil's-claw control and cotton injury with pyrithiobac applied PPI, PRE, or POST. Pyrithiobac at 36 or 71 g ae/ha applied PPI, PRE, or POST did not injure cotton. Pyrithiobac at 140 g/ha applied PPI or PRE injured cotton 9 to 11% 6 wk after treatment. Cotton recovered and no injury was observed 12 wk after treatment. Pyrithiobac applied PPI and PRE at 71 g/ha controlled Palmer amaranth at least 97% 6 wk after treatment. Palmer amaranth control with pyrithiobac applied POST was more variable and influenced by environmental conditions. Palmer amaranth control with 71 g/ha of pyrithiobac exceeded that with 36 g/ha. Devil's-claw control with pyrithiobac was better with POST applications than PPI or PRE applications. Pyrithiobac applied POST at 140 g/ha controlled devil's-claw 83–97%. These studies indicate that pyrithiobac can effectively control Palmer amaranth and devil's-claw in cotton on the Texas Southern High Plains when applied at appropriate rates and timings.
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18

Brendler, Thomas, Joerg Gruenwald, Catherine Ulbricht, and Ethan Basch. "Devil's Claw (Harpagophytum procumbens DC)." Journal Of Herbal Pharmacotherapy 6, no. 1 (2006): 89–126. http://dx.doi.org/10.1300/j157v06n01_09.

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19

Barnes, Joanne. "Charms & Harms: Devil's Claw." Journal of Primary Health Care 1, no. 3 (2009): 238. http://dx.doi.org/10.1071/hc09238.

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SUMMARY MESSAGE: There is evidence that Devil’s Claw can be an effective short-term treatment for acute exacerbations of low back pain and, to a lesser extent, in rheumatic and osteoarthritic conditions. Acute adverse effects reported in clinical trials were mild diarrhoea and flatulence. Long-term adverse effects have not been studied. As with all herbal medicines, Devil’s Claw products differ in their pharmaceutical quality, and the implications of this for efficacy and safety should be considered.
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20

Mercer, Kay L., John A. Pawlak, Don S. Murray, Laval M. Verhalen, Michael S. Riffle, and Ronald W. McNew. "Distance-of-Influence of Devil's-Claw (Proboscidea louisianica) on Cotton (Gossypium hirsutum)." Weed Technology 4, no. 1 (1990): 87–91. http://dx.doi.org/10.1017/s0890037x00025045.

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The distance-of-influence of an individual devil's-claw plant to cotton leaf, stem, boll (reproductive parts), and combined aboveground plant parts was determined in two field experiments. The distance-of-influence could not be detected for the first 6 weeks after emergence; by 9 to 12 weeks, it extended up to 25 cm or more; and by the end of the season, up to 50 cm on each side of the weed. Cotton leaf and stem weights were less sensitive than cotton boll weights for measuring distance-of-influence from devil's-claw. At maturity, cotton boll weight was reduced 62 and 51% in 1983 and 45 and 29% in 1984 for sampling intervals of 0 to 25 and 25 to 50 cm, respectively. Interference from cotton reduced devil's-claw stem weight, seed capsule weight, and whole plant biomass by 6 weeks after emergence and reduced leaf biomass by 9 weeks in 1983. All except stem biomass were affected in 1984. Distance-of-influence and weed-density interference studies predicted lint yield loss similarly.
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21

Chrubasik, S. "Effectiveness of devil's claw for osteoarthritis." Rheumatology 41, no. 11 (2002): 1332–33. http://dx.doi.org/10.1093/rheumatology/41.11.1332.

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22

Ribeiro, Gislane Dos Santos, Amanda De Assis Carneiro, Diegue Henrique Nascimento Martins, et al. "Determination of harpagoside in Harpagophytum procumbens DC tablet’s using analytical method by High Performance Liquid Chromatography." Eclética Química Journal 45, no. 1 (2020): 47. http://dx.doi.org/10.26850/1678-4618eqj.v45.1.2020.p47-55.

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The species Harpagophytum procumbens DC. is popularly known as devil’s claw and is widely used because of its anti-inflammatory properties that are attributed to an iridoid glycoside, the harpagoside. This medicinal plant is part of the Brazilian List of Essential Medicines, that is, it was selected and standardized for the resolution of diseases in the Brazilian public health system, SUS, and can be found in several brands. Due to the importance of quality monitoring, the objective of this study was to create and validate a method for identification and quantification of harpagoside in tablets of the devil’s claw, as well as to evaluate the content of this iridoid glycoside in three commercially available brands in Brasília, DF, Brazil. The evaluated parameters in the validation by high performance liquid chromatography (HPLC) were linearity, limits of detection and quantification, precision, selectivity, accuracy and robustness, as required by the Brazilian regulation. The developed and validated method proved satisfactory for the quality control of commercial products that present in this composition the medicinal plant. All the devil’s claw brands presented divergences regarding the quality that can interfere with therapeutics and with safety and efficacy.
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Diaz-Silveira, Genelle L., Joan Deutsch, and Damon P. Little. "DNA Barcode Authentication of Devil’s Claw Herbal Dietary Supplements." Plants 10, no. 10 (2021): 2005. http://dx.doi.org/10.3390/plants10102005.

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Devil’s claw is the vernacular name for a genus of medicinal plants that occur in the Kalahari Desert and Namibia Steppes. The genus comprises two distinct species: Harpagophytum procumbens and H. zeyheri. Although the European pharmacopeia considers the species interchangeable, recent studies have demonstrated that H. procumbens and H. zeyheri are chemically distinct and should not be treated as the same species. Further, the sale of H. zeyheri as an herbal supplement is not legal in the United States. Four markers were tested for their ability to distinguish H. procumbens from H. zeyheri: rbcL, matK, nrITS2, and psbA-trnH. Of these, only psbA-trnH was successful. A novel DNA mini-barcode assay that produces a 178-base amplicon in Harpagophytum (specificity = 1.00 [95% confidence interval = 0.80–1.00]; sensitivity = 1.00 [95% confidence interval = 0.75–1.00]) was used to estimate mislabeling frequency in a sample of 23 devil’s claw supplements purchased in the United States. PCR amplification failed in 13% of cases. Among the 20 fully-analyzable supplements: H. procumbens was not detected in 75%; 25% contained both H. procumbens and H. zeyheri; none contained only H. procumbens. We recommend this novel mini-barcode region as a standard method of quality control in the manufacture of devil’s claw supplements.
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Ibrahim, K. E., R. M. Al-Ashban, and S. A. El-Sammani. "Toxicity Studies on Devil's Claw Herbal Medicine." Research Journal of Pharmacology 4, no. 3 (2010): 69–73. http://dx.doi.org/10.3923/rjpharm.2010.69.73.

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Mundy, Peter J., and Sibonokuhle F. Ncube. "Devil’s Claw – a natural substitute for diclofenac?" Vulture News 67, no. 2 (2015): 43. http://dx.doi.org/10.4314/vulnew.v67i2.

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Lima, Valtieri Bortoluzzi de, Mariana Fernandes Ribeiro, Cristiane Köhler Carpilovsky, Paula Köhler Carpilovsky, and Luciana Maria Fontanari Krause. "Devil's claw: action on the central nervous system." Disciplinarum Scientia - Ciências da Saúde 21, no. 3 (2020): 65–72. http://dx.doi.org/10.37777/dscs.v21n3-006.

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Qi, Jin, Ji-Jun Chen, Zhi-Hong Cheng, Jia-Hong Zhou, Bo-Yang Yu, and Samuel X. Qiu. "Iridoid glycosides from Harpagophytum procumbens D.C. (devil’s claw)." Phytochemistry 67, no. 13 (2006): 1372–77. http://dx.doi.org/10.1016/j.phytochem.2006.05.029.

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28

Homova, Vediha, Jost Weber, Josef Schulze, Kalina Alipieva, Thomas Bley, and Milen Georgiev. "Devil’s Claw Hairy Root Culture in Flasks and in a 3-L Bioreactor: Bioactive Metabolite Accumulation and Flow Cytometry." Zeitschrift für Naturforschung C 65, no. 7-8 (2010): 472–78. http://dx.doi.org/10.1515/znc-2010-7-809.

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Phenylethanoids are a group of natural water-soluble compounds with high biological value, which could potentially be commercially produced by hairy root cultures. Thus, we have examined the capacity of transformed root cultures of Devil’s claw (Harpagophytum procumbens) to accumulate four phenylethanoid glycosides - β-OH-verbascoside, verbascoside, leucosceptoside A, and martynoside - in shake-flasks and a 3-L stirred tank reactor. Verbascoside was found to be the major phenylethanoid, and its maximal contents were the same (1.12 mg/g dry weight) in both kinds of culture. However, peak leucosceptoside A contents were 1.6-times higher in bioreactor cultures than in shake-flask cultures. Flow cytometry analysis revealed that G0 + G1-phase cells predominated throughout the growth of the cultures, which was in accordance with the very high proportion of quiescent cells in the transformed roots. The results provide the first demonstration of the potential utility of Devil’s claw hairy roots as biofactories for producing high-value phenylethanoid glycosides.
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Cole, D., and A. Bustan. "DEVIL'S CLAW: HOW TO BRIDGE BETWEEN OVEREXPLOITATION AND UNDERUTILIZATION." Acta Horticulturae, no. 806 (January 2009): 603–14. http://dx.doi.org/10.17660/actahortic.2009.806.75.

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30

Riffle, Michael S., George R. Waller, Don S. Murray, and Richard P. Sgaramello. "Devil's-claw (Proboscidea louisianica), essential oil and its components." Journal of Chemical Ecology 16, no. 6 (1990): 1927–40. http://dx.doi.org/10.1007/bf01020506.

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Stewart, Kristine M., and David Cole. "The commercial harvest of devil's claw (Harpagophytum spp.) in southern Africa: The devil's in the details." Journal of Ethnopharmacology 100, no. 3 (2005): 225–36. http://dx.doi.org/10.1016/j.jep.2005.07.004.

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Stancheva, Nina, Jost Weber, Josef Schulze, et al. "Phytochemical and flow cytometric analyses of Devil’s claw cell cultures." Plant Cell, Tissue and Organ Culture (PCTOC) 105, no. 1 (2010): 79–84. http://dx.doi.org/10.1007/s11240-010-9844-z.

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33

Philippe, Mentaz, Emmy Wang, Evan Wang, et al. "New cultivars." Carnivorous Plant Newsletter 51, no. 4 (2022): 207–11. http://dx.doi.org/10.55360/cpn514.cv514.

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Hartmeyer, Siegfried R. H., and Irmgard Hartmeyer. "Proboscidea and Dicyphini: An example of spontaneous mutualism by a population of predatory bugs inhabiting a sticky plant." Carnivorous Plant Newsletter 51, no. 4 (2022): 178–84. http://dx.doi.org/10.55360/cpn514.sh212.

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A population of the mirid-bug Dicyphus errans (Miridae) a species occurring in Europe, colonized a group of Devil’s Claw (Proboscidea louisianica subsp. fragrans (Martyniaceae)) native to the USA and cultivated in a garden in Germany. More than 20 individuals of these predatory bugs have been found living and moving freely on these sticky plants, feeding on stuck victims, while garden ants (Lasius spp. (Hymenoptera)) trying to place aphids for “sugar farming” became captured together with their “productive livestock”, as do small flies and bees. The observations on this spontaneous mutualism between the American Devil’s Claw and a small mosquito-like European mirid-bug has been recorded on video (Hartmeyer 2022). This constitutes an additional example for the adaptation of these ubiquitous predatory bugs to feed on the prey of sticky plants that would usually capture small-sized insects. The American Frank Obregon (2017), who found native mirid-bugs on his cultivated Roridula (Roridulaceae) in California, called the phenomenon assisted carnivory, which fits quite nicely. Proboscidea as well as Roridula do not produce digestive enzymes, so they cannot benefit directly from their diverse captured prey. But as soon as predatory bugs colonize the plants and feed on the sticking prey, their droppings provide a suitable fertilizer to be absorbed by the stomata of the leaf. A perfect mutualism. In addition, some historic facts on bug-plant interaction are provided.
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35

Tellermann, Esther. "Ut musica poesis, « et je devins celui qui désire autre chose »." La clinique lacanienne 34, no. 2 (2023): 131–36. http://dx.doi.org/10.3917/cla.034.0131.

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36

Cuspidi, Cesare, Carla Sala, Marijana Tadic, Guido Grassi, and Giuseppe Mancia. "Systemic Hypertension Induced by Harpagophytum procumbens (devil's claw): A Case Report." Journal of Clinical Hypertension 17, no. 11 (2015): 908–10. http://dx.doi.org/10.1111/jch.12593.

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37

McGregor, Gerard, Bernd Fiebich, Andrea Wartenberg, Sarah Brien, George Lewith, and Tankred Wegener. "Devil’s Claw (Harpagophytum procumbens): An Anti-Inflammatory Herb with Therapeutic Potential." Phytochemistry Reviews 4, no. 1 (2005): 47–53. http://dx.doi.org/10.1007/s11101-004-2374-8.

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Georgiev, Milen, Kalina Alipieva, Svetlana Pashova, et al. "Antioxidant activity of devil’s claw cell biomass and its active constituents." Food Chemistry 121, no. 4 (2010): 967–72. http://dx.doi.org/10.1016/j.foodchem.2010.01.028.

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39

Arranz, Isabel, Eric Sizoo, Hans Van Egmond, et al. "Determination of Aflatoxin B1 in Medical Herbs: Interlaboratory Study." Journal of AOAC INTERNATIONAL 89, no. 3 (2006): 595–605. http://dx.doi.org/10.1093/jaoac/89.3.595.

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Abstract A method was developed for the determination of aflatoxin B1 in medical herbs (senna pods, botanical name Cassia angustifolia; devil's claw, botanical name Harpagophytum procumbens; and ginger roots, botanical name Zingiber officinale). The method, which was tested in a mini-collaborative study by 4 laboratories, is based on an immunoaffinity cleanup followed by reversed-phase high-performance liquid chromatography separation and fluorescence detection after post-column derivatization. It allows the quantitation of aflatoxin B1 at levels lower than 2 ng/g. A second extractant (acetonewater) was tested and compared to the proposed methanolwater extractant. Several post-column derivatization options (electrochemically generated bromine, photochemical reaction, and chemical bromination) as well as different integration modes (height versus area) were also investigated. No differences were found depending on the choice of derivatization system or the signal integration mode used. The method was tested for 3 different matrixes: senna pods, ginger root, and devil's claw. Performance characteristics were established from the results of the study and resulted in HorRat values ranging from 0.12 to 0.75 with mean recoveries from 78 to 91% for the extraction with methanolwater and HorRat values ranging from 0.101.03 with mean recoveries from 98 to 103% for the extraction with acetonewater. As a result, the method, with all tested variations, was found to be fit-for-purpose for the determination of aflatoxin B1 in medical herbs at levels of 1 g/kg and above.
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40

Brendler, Thomas. "From Bush Medicine to Modern Phytopharmaceutical: A Bibliographic Review of Devil’s Claw (Harpagophytum spp.)." Pharmaceuticals 14, no. 8 (2021): 726. http://dx.doi.org/10.3390/ph14080726.

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Devil’s claw (Harpagophytum spp., Pedaliaceae) is one of the best-documented phytomedicines. Its mode of action is largely elucidated, and its efficacy and excellent safety profile have been demonstrated in a long list of clinical investigations. The author conducted a bibliographic review which not only included peer-reviewed papers published in scientific journals but also a vast amount of grey literature, such as theses and reports initiated by governmental as well as non-governmental organizations, thus allowing for a more holistic presentation of the available evidence. Close to 700 sources published over the course of two centuries were identified, confirmed, and cataloged. The purpose of the review is three-fold: to trace the historical milestones in devil’s claw becoming a modern herbal medicine, to point out gaps in the seemingly all-encompassing body of research, and to provide the reader with a reliable and comprehensive bibliography. The review covers aspects of ethnobotany, taxonomy, history of product development and commercialization, chemistry, pharmacology, toxicology, as well as clinical efficacy and safety. It is concluded that three areas stand out in need of further investigation. The taxonomical assessment of the genus is outdated and lacking. A revision is needed to account for intra- and inter-specific, geographical, and chemo-taxonomical variation, including variation in composition. Further research is needed to conclusively elucidate the active compound(s). Confounded by early substitution, intermixture, and blending, it has yet to be demonstrated beyond a reasonable doubt that both (or all) Harpagophytum spp. are equally (and interchangeably) safe and efficacious in clinical practice.
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Ncube, Sibonokuhle F., Hilton G. T. Ndagurwa, Peter J. Mundy, Samson Sibanda, and Mthokozisi Dlodlo. "Ethnobotanical knowledge and use-value of Harpagophytum (Devil's claw) in Matabeleland, Zimbabwe." South African Journal of Botany 144 (January 2022): 134–44. http://dx.doi.org/10.1016/j.sajb.2021.08.015.

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42

Kriukova, A. I., I. M. Vladymyrova, S. M. Gubar, A. G. Kotov, and E. E. Kotova. "Question introduction to the State Pharmacopoeia of Ukraine monograph «Devil’s claw root»." Upravlìnnâ, ekonomìka ta zabezpečennâ âkostì v farmacìï, no. 1(53) (March 5, 2018): 6–12. http://dx.doi.org/10.24959/uekj.18.3.

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43

Nabhan, Gary Paul. "Plant Domestication and Folk-Biological Change: The Upper Piman/Devil's Claw Example." American Anthropologist 89, no. 1 (1987): 57–73. http://dx.doi.org/10.1525/aa.1987.89.1.02a00030.

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44

Avato, Pinarosa, and Maria Pia Argentieri. "Quality Assessment of Commercial Spagyric Tinctures of Harpagophytum procumbens and Their Antioxidant Properties." Molecules 24, no. 12 (2019): 2251. http://dx.doi.org/10.3390/molecules24122251.

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Preparations from the dried tubers of Harpagophytum procumbens (Burch.) DC ex Meisn, commonly known as devil’s claw, are mainly used in modern medicine to relieve joint pain and inflammation in patients suffering from rheumatic and arthritic disorders. This paper describes for the first time the chemical profile of a commercial spagyric tincture (named 019) prepared from the roots of the plant. For comparison purposes, a commercial not-spagyric devil’s claw tincture (NST) was also analyzed. Chemical investigation of the content of specialized metabolites in the three samples indicated that harpagoside was the main compound, followed by the two isomers acteoside and isoacteoside. Compositional consistence over time was obtained by the chemical fingerprinting of another spagyric tincture (named 014) from the same producer that was already expired according to the recommendation on the label of the product. The two spagyric preparations did not show significant compositional differences as revealed by HPLC and MS analyses, except for a decrease in harpagide content in the expired 014 tincture. Moreover, their antioxidant capacities as assessed by 2,2’-di-phenyl-1-picrylhydrazyl (DPPH) and 2.2’-azin-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods resulted in very similar IC50 values. The expired 014 tincture showed instead a lower IC50 value compared to the 019 and NST tinctures with the ferric reducing antioxidant potential (FRAP) assay, indicating a higher ferric-reducing antioxidant ability. Overall, these results indicated that the two preparations could generally maintain good stability and biological activity at least for the four years from the production to the expiration date.
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Rice, Barry. "Reassessing commensal-enabled carnivory in Proboscidea and Ibicella?" Carnivorous Plant Newsletter 37, no. 1 (2008): 15–19. http://dx.doi.org/10.55360/cpn371.br188.

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In 1999 I conducted experiments to look for enzymatic activity on the glandular leaves of Ibicella lutea (Pedaliaceae), also known as the devil’s claw or unicorn plant. I saw no evidence for enzymes, inferred the plants were not carnivorous, and wrote that “These are interesting plants, but I have no room for them in my carnivorous garden. The seeds I will send to the ICPS seed bank will be my last”. Furthermore, on my web site I wrote that “…on the whole, I have lost interest in this non-carnivore” (Rice 2004). Ah, how presumptuous I was.
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46

Grichar, W. J., P. A. Dotray, and D. C. Sestak. "Diclosulam for Weed Control in Texas Peanut1." Peanut Science 26, no. 1 (1999): 23–28. http://dx.doi.org/10.3146/i0095-3679-26-1-6.

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Abstract Field experiments were conducted in 1995 through 1997 in south and west Texas to evaluate diclosulam [N-(2,6-dichlorophenyl)-5-ethoxy-7-fluoro(1,2,4)-triazolo(1,5c)-pyrimidine-2-sulfonamide] for weed control in peanut. Diclosulam applied preplant incorporated at 0.01 kg ai/ha in combination with ethalfluralin at 0.84 kg ai/ha controlled Texas panicum, Palmer amaranth, morningglory species, and golden crownbeard at least 95% and devil's-claw 91%. When diclosulam rates were increased to 0.02 kg/ha, yellow and purple nutsedge were controlled at least 89 and 72%, respectively. Diclosulam applied postemergence (POST) provided erratic yellow nutsedge control.
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Gxaba, Nomagugu, and Madira Coutlyne Manganyi. "The Fight against Infection and Pain: Devil’s Claw (Harpagophytum procumbens) a Rich Source of Anti-Inflammatory Activity: 2011–2022." Molecules 27, no. 11 (2022): 3637. http://dx.doi.org/10.3390/molecules27113637.

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Harpagophytum procumbens subsp. procumbens (Burch.) DC. ex Meisn. (Sesame seed Family—Pedaliaceae) is a popular medicinal plant known as Devil’s claw. It is predominantly distributed widely over southern Africa. Its impressive reputation is embedded in its traditional uses as an indigenous herbal plant for the treatment of menstrual problems, bitter tonic, inflammation febrifuge, syphilis or even loss of appetite. A number of bioactive compounds such as terpenoids, iridoid glycosides, glycosides, and acetylated phenolic compounds have been isolated. Harpagoside and harpagide, iridoid glycosides bioactive compounds have been reported in countless phytochemical studies as potential anti-inflammatory agents as well as pain relievers. In-depth studies have associated chronic inflammation with various diseases, such as Alzheimer’s disease, obesity, rheumatoid arthritis, type 2 diabetes, cancer, and cardiovascular and pulmonary diseases. In addition, 60% of chronic disorder fatalities are due to chronic inflammatory diseases worldwide. Inflammation and pain-related disorders have attracted significant attention as leading causes of global health challenges. Articles published from 2011 to the present were obtained and reviewed in-depth to determine valuable data findings as well as knowledge gaps. Various globally recognized scientific search engines/databases including Scopus, PubMed, Google Scholar, Web of Science, and ScienceDirect were utilized to collect information and deliver evidence. Based on the literature results, there was a dramatic decrease in the number of studies conducted on the anti-inflammatory and analgesic activity of Devil’s claw, thereby presenting a potential research gap. It is also evident that currently in vivo clinical studies are needed to validate the prior massive in vitro studies, therefore delivering an ideal anti-inflammatory and analgesic agent in the form of H. procumbens products.
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48

Muzila, Mbaki, Kimmo Rumpunen, Helen Wright, et al. "Alteration of Neutrophil Reactive Oxygen Species Production by Extracts of Devil’s Claw (Harpagophytum)." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/3841803.

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Harpagophytum, Devil’s Claw, is a genus of tuberiferous xerophytic plants native to southern Africa. Some of the taxa are appreciated for their medicinal effects and have been traditionally used to relieve symptoms of inflammation. The objectives of this pilot study were to investigate the antioxidant capacity and the content of total phenols, verbascoside, isoverbascoside, and selected iridoids, as well as to investigate the capacity of variousHarpagophytumtaxa in suppressing respiratory burst in terms of reactive oxygen species produced by human neutrophils challenged with phorbol myristate acetate (PMA), opsonisedStaphylococcus aureus,andFusobacterium nucleatum.Harpagophytumplants were classified into different taxa according to morphology, and DNA analysis was used to confirm the classification. A putative new variety ofH. procumbensshowed the highest degree of antioxidative capacity. Using PMA, threeHarpagophytumtaxa showed anti-inflammatory effects with regard to the PBS control. A putative hybrid betweenH. procumbensandH. zeyheriin contrast showed proinflammatory effect on the response of neutrophils toF. nucleatumin comparison with treatment with vehicle control.Harpagophytumtaxa were biochemically very variable and the response in suppressing respiratory burst differed. Further studies with larger number of subjects are needed to corroborate anti-inflammatory effects of different taxa ofHarpagophytum.
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Romiti, Nadia, Gianfranco Tramonti, Alessandro Corti, and Elisabetta Chieli. "Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein." Phytomedicine 16, no. 12 (2009): 1095–100. http://dx.doi.org/10.1016/j.phymed.2009.05.001.

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Gyurkovska, Valeriya, Kalina Alipieva, Alexandre Maciuk, et al. "Anti-inflammatory activity of Devil’s claw in vitro systems and their active constituents." Food Chemistry 125, no. 1 (2011): 171–78. http://dx.doi.org/10.1016/j.foodchem.2010.08.056.

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