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Journal articles on the topic 'Dexmedemtomidine Fentanyl Bupivacaine Spinal Anaesthesia'

Author: Grafiati

Published: 3 June 2025

Last updated: 1 August 2025

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1

Yudha, Ferriansyah, and Setiadi Bakti. "Regional anaesthesia is a major factor in patient safety during Caesarean delivery." International Journal of Innovative Science and Research Technology 7, no. 12 (2022): 367–73. https://doi.org/10.5281/zenodo.7480801.

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Regional anaesthesia is a major factor in patient safety during Caesarean delivery. Resurgence of spinal anaesthesia as a popular technique was possible due to the development of small-bore needles with pencil-point tips and has become the preferred method of anaesthesia for elective and for many emergency Caesarean deliveries.1 A survey of Society for Obstetric Anesthesia and Perinatology members found that spinal anesthesia is most commonly used for elective cesarean delivery (85% respondents), with 90% of these respondents preferring hyperbaric 0.75% bupivacaine. Further, 79% of responders

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G. Patel, Mamta, Ashka V. Surve, Arun George, Mittal S. Patel, Urvisha A. Mendpara, and Kavan J. Patel. "COMPARISON OF BUPIVACAINE-DEXMEDETOMIDINE VS BUPIVACAINE-FENTANYL VS BUPIVACAINE -SALINE FOR UNILATERAL SPINAL ANAESTHESIA IN LOWER LIMB SURGERY." International Journal of Advanced Research 11, no. 05 (2023): 1599–607. http://dx.doi.org/10.21474/ijar01/17028.

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Introduction: Addition of adjuvants like Dexmedetomidine and Fentanyl to hyperbaric Bupivacaine has been proposed to improve the quality of spinal anaesthesia. Aims and Objectives: The aim of current study was to compare the effects of adding Dexmedetomidine, Fentanyl and saline to low dose hyperbaric Bupivacaine (1 ml, 0.5%) on the properties of unilateral spinal anaesthesia. Methods and Materials: 120 patients divided into three groups. The spinal anaesthetic agent in each of the three groups was 1 mL bupivacaine 0.5% (5 mg). In groups BD, BF and BS, 5mcg of Dexmedetomidine, 25mg of Fentanyl

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Mamun, Md Al, Md Rabiul Alam, Suraya Akter, and Mozibul Haque. "Role of Fentanyl With Bupivacaine During Spinal Anaesthesia for Caesarean Section in Reducing Hypotension." Journal of the Bangladesh Society of Anaesthesiologists 32, no. 1 (2019): 28–34. http://dx.doi.org/10.3329/jbsa.v32i1.66550.

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Background and Objectives: The hypotension following spinal anaesthesia is a common problem incaesarean section. The combination of reduced dose of local anaesthetics with intrathecal opioids makesit possible to achieve adequate spinal anaesthesia with minimum hypotension. We investigated whetherthis synergistic phenomenon could be used to provide less frequent hypotension while incurring adequatespinal anaesthesia for caesarean section. Methods: Sixty women scheduled for caesarean delivery (thirty in each group) were divided into twogroups of patients who received a spinal injection of either

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S., Kalyan, and Ch Anil Kumar. "A Prospective Randomized Clinical Study on Spinal Anaesthesia Using Isobaric Levobupivacaine Versus Hyperbaric Bupivacaine (with Fentanyl) in Elective Caesarean Sections." Journal of Evolution of Medical and Dental Sciences 11, no. 1 (2022): 115–19. http://dx.doi.org/10.14260/jemds/2022/22.

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BACKGROUND Bupivacaine being an amide is used in hyperbaric and isobaric forms as a spinal anaesthetic for surgeries requiring regional anaesthesia. Spinal anaesthesia is an accepted form of anaesthesia for elective and emergency caesarean sections. Bupivacaine used in spinal anaesthesia produces analgesia, anaesthesia, and motor block. Grading the effects of the anaesthetic is based on volume, concentration, and dose. The present study analysed the role of both types of bupivacaine supplemented by fentanyl. Here we wanted to study the anaesthetic effects of isobaric levobupivacaine versus hyp

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Ali Hussein, Taaer. "comparative study of intrathecal bupivacaine with fentanyl and medazolam for quality of anaesthesia and duration of post operative pain relieve in patient undergoing orthopaedic surgery." AL-QADISIYAH MEDICAL JOURNAL 12, no. 22 (2017): 199–203. http://dx.doi.org/10.28922/qmj.2016.12.22.199-203.

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The use of adjuvant to spinal anaesthesia has gained popularity nowdays , improve the quality of anaesthesia and post operative pain relieve is mandatory for patient care and to reduce complication , in this retrospective randomized study taken among 120 patient divided into 3 groups a,b and c in the A group received bupivacaine 0.5 % heavy ( marcaine) , B group received 0.5 % bupivacaine 2.5 ml plus 25 microgram fentanyl, C GROUP received 0.5% bupivacaine plus 2.5 mg midazolam after preloading of fluid ( normal saline) and montoring of vital sign and postoperative pain , the result showed tha

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Vivek, Singh, and Katiyar Gunjan. "Spinal Anaesthesia for Elective Cesarean Section with Bupivacaine Associated with Different Doses of Fentanyl." International Journal of Pharmaceutical and Clinical Research 14, no. 12 (2022): 1294–300. https://doi.org/10.5281/zenodo.13882751.

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<strong>Introduction:</strong> Spinal anaesthesia is commonly used in cesarean section using bupivacaine for anaesthetic effect at low dosage which is given with fentanyl. This enhances the anesthetic effect, lengthen the duration of anesthesia, minimize the post-operative nausea and vomiting. Although there are conflicting findings about the effectiveness of fentanyl when used with local anaesthetics. The drawbacks of continuous spinal anaesthesia includes probable post-dural puncture headache, technical challenges, and neurologic problems.  Microcatheters allowed to modify the dosa

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Damyant, Tripathi, Shikha Deep, Supriya, et al. "Comparison of Effects of Neostigmine and Fentanyl as Adjuvants to Hyperbaric Bupivacaine (0.5%) in Spinal Anaesthesia for Lower Abdominal and Lower Extremity Surgery." International Journal of Pharmaceutical and Clinical Research 16, no. 10 (2024): 497–508. https://doi.org/10.5281/zenodo.14037072.

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<strong>Introduction: </strong>Augustus Bier performed the first spinal anaesthesia using cocaine in 1889. Bupivacaine 0.5% heavy was the only drug used for spinal anaesthesia after the discontinuation of lidocaine’s intrathecal use. Bradycardia and hypotension are the hemodynamic side effects of use of high dose of local anaesthetic agent to prolong the duration of analgesia. Neostigmine is a cholinesterase inhibitor which leads to an increase of the acetylcholine concentration. The present study was undertaken to compare the efficacy of fentanyl and n

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M H, Chandana, and P. G. Raghvendra. "Comparative Study of Isobaric Levobupivacaine Alone and Isobaric Levobupivacaine with Fentanyl for Spinal Anaesthesia in Lower Abdominal Surgeries." Indian Journal of Anesthesia and Analgesia 8, no. 3 (2021): 357–62. http://dx.doi.org/10.21088/ijaa.2349.8471.8321.45.

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Introduction: Levobupivacaine 0.5% and racemic bupivacaine 0.5% are equally effective in spinal anaesthesia with less systemic toxicity seen with levobupivacaine. Fentanyl has been used as an adjunct to racemic bupivacaine in spinal anaesthesia. This study was designed to study on the intrathecal use of 0.5% levobupivacaine with fentanyl in elective lower abdominal surgeries. Methods: A prospective randomized controlled double blind study was conducted in100 patients of ASA I and II physical status posted for elective lower abdominal surgeries under subarachnoid block, randomized into 2 groups

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Veena, Horo, and Ranjan Ashutosh. "Study of Incidence of Shivering in Patients undergoing Lower Segment Caesarian Section (LSCS) under Spinal Anaesthesia with Bupivacaine vs Bupivacaine with Fentanyl." International Journal of Pharmaceutical and Clinical Research 14, no. 7 (2022): 662–69. https://doi.org/10.5281/zenodo.13372076.

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<strong>Background:</strong> Shivering is a normal thermoregulatory mechanism in patients undergoing central neuraxial anaesthesia. Shivering is common in women undergoing caesarian section under spinal anaesthesia and can interfere with patients monitoring. It can cause discomfort to patient and also increases tissue oxygen demand. The aim of the study was to evaluate the incidence of shivering with addition of 10-25mcg of fentanyl to bupivacaine in patients undergoing LSCS under spinal anaesthesia. <strong>Material and Method: </strong>A total of 60 healthy women belonging to

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Acharya, Sulav, Sabin Bhandari, and Sushmita Bhandari. "Study of effectiveness of two syringe spinal anaesthesia technique for caesarean section." Nepal Medical College Journal 25, no. 4 (2023): 296–300. http://dx.doi.org/10.3126/nmcj.v25i4.60875.

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Spinal anaesthesia using hyperbaric bupivacaine is the most popular method for caesarean section. Adjuvents like fentanyl which enhances the sensory block and provide stable haemodynamics are usually premixed with bupivacaine in a single syringe. Fentanyl when added to hyperbaric bupivacaine, decreases the density of solution to extent of 0.0006 which alters the spread of local anesthetics in CSF. If we inject both the drugs separately in different syringe, it may minimize the effect of the changes in densities and PH of both the drugs and produce their maximum effect with minimal haemodynamic

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Srinivasaiah, Madhu, Dhananjeyulu Padmaraju, Surekha Gadiraju, and Bhavya Nidiginti. "Comparison of nalbuphine and fentanyl as adjuvants to bupivacaine in unilateral spinal anaesthesia in patients undergoing lower limb orthopaedic surgeries." Indian Journal of Clinical Anaesthesia 9, no. 2 (2022): 169–73. http://dx.doi.org/10.18231/j.ijca.2022.035.

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Unilateral spinal anaesthesia is a technique used to avoid hemodynamic changes and early recovery. Adjuvants are added to prolong post operative analgesia, this study was done to compare nalbuphine (0.8mg) and fentanyl (20µg) as adjuvants to 0.5% bupivacaine Heavy in unilateral spinal anaesthesia for patients undergoing lower limb orthopaedic surgeries. Randomized double blind study in patients posted for lower limb orthopaedic surgery in a teritiary care center.Unilateral spinal anaesthesia was given to 68 eligible patients undergoing lower limb orthopaedic surgery with nalbuphine (0.8mg) and

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Thapa, Rashmi, Pooja Pooja Paudyal, Bishwas Pradhan, Megha Koirala, and Bashu Dev Parajuli. "Comparison Between Hyperbaric Bupivacaine with and Without Fentanyl in Reducing Visceral Pain During Cesarean Delivery Under Spinal Anaesthesia." Journal of Nepal Health Research Council 23, no. 01 (2025): 25–30. https://doi.org/10.33314/jnhrc.v23i01.5397.

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Background: Visceral pain occurred during cesarean delivery during spinal anesthesia can be decreased with a higher dose of bupivacaine. However, larger doses of bupivacaine increases the risk of high sensory block. We hypothesized that addition of fentanyl to bupivacaine intrathecally could intensifies the sensory block and improves the quality of intraoperative analgesia. The aim of this study is to compare incidence of visceral pain between hyperbaric bupivacaine with or without fentanyl during cesarean delivery under spinal anesthesia. Methods: In this prospective randomized controlled tri

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Shah, Vishruti R., Shweta Mehta, and Danish A. Khan. "Comparative study of intrathecal fentanyl with bupivacaine and fentanyl midazolam with bupivacaine in spinal anaesthesia." Indian Journal of Clinical Anaesthesia 8, no. 2 (2021): 302–9. http://dx.doi.org/10.18231/j.ijca.2021.056.

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Spinal anaesthesia is preferred for lower abdominal and lower limb surgeries. Bupivacaine is the most popular local anaesthetic for subarachnoid blockade because of less neurotoxicity. Intrathecal bupivacaine alone may be insufficient to provide prolonged post-operative analgesia, even with high sensory block. So, various adjuvants are used like ketamine, midazolam, clonidine, opioids, neostigmine etc. to prolong the effect of local anaesthetic.To compare the effect of intrathecal fentanyl and fentanyl-midazolam combination with hyperbaric bupivacaine for quality of anaesthesia and post-operat

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Kaban, Ozden Gorgoz, Dilek Yazicioglu, Taylan Akkaya, M. Murat Sayin, Duray Seker, and Haluk Gumus. "Spinal Anaesthesia with Hyperbaric Prilocaine in Day-Case Perianal Surgery: Randomised Controlled Trial." Scientific World Journal 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/608372.

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Background. The local anaesthetics used in day-case spinal anaesthesia should provide short recovery times. We aimed to compare hyperbaric prilocaine and bupivacaine in terms of sensory block resolution and time to home readiness in day-case spinal anaesthesia.Methods. Fifty patients undergoing perianal surgery were randomized into two groups. The bupivacaine-fentanyl group (Group B) received 7.5 mg, 0.5% hyperbaric bupivacaine + 20 μg fentanyl in total 1.9 mL. The prilocaine-fentanyl group (Group P) received 30 mg, 0.5% hyperbaric prilocaine + 20 μg fentanyl in the same volume.Results. Time t

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Agrawal, Dipty, Niyati Sinha, and Shiv Kumar Singh. "Comparison of intrathecal dexmedetomidine and intrathecal fentanyl as an adjuvant to bupivacaine during spinal anaesthesia for lower limb orthopedic surgery." Asian Journal of Medical Sciences 14, no. 6 (2023): 57–62. http://dx.doi.org/10.3126/ajms.v14i6.52044.

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Background: In this study, we have compared the addition of fentanyl 25 mcg and dexmedetomidine 5 mcg to 15 mg of 0.5% hyperbaric bupivacaine for spinal anesthesia separately for patient undergoing lower limb orthopedic surgery. Dexmedetomidine is an α-2 adrenoreceptor agonist and it can prolong the motor and sensory block for long spinal anesthesia. It act by binding to presynaptic C-fiber and postsynaptic dorsal horn neurons. The analgesic action is a result of depression of release of C-fiber transmitters and hyperpolarization of postsynaptic dorsal horn neurons. Aims and Objectives: The pr

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Gurbet, A., G. Turker, NK Girgin, H. Aksu, and NH Bahtiyar. "Combination of Ultra-Low Dose Bupivacaine and Fentanyl for Spinal Anaesthesia in Out-Patient Anorectal Surgery." Journal of International Medical Research 36, no. 5 (2008): 964–70. http://dx.doi.org/10.1177/147323000803600512.

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This study investigated whether the addition of 25 μg fentanyl to an ultra-low (sub-anaesthetic) dose of intrathecal bupivacaine provides adequate anaesthesia for out-patient anorectal surgery, without increasing side-effects or delaying hospital discharge. Patients were randomly allocated to receive 2.5 mg 0.5% bupivacaine plus 25 μg fentanyl (group BF, n = 18) or 5 mg 0.5% bupivacaine alone (group B, n = 17). There were no significant differences in intra-operative outcomes, but mean recovery and discharge times were significantly shorter in group BF. There were no between-group differences

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Singh, Abhilasha, Shivpriya P.N, Sanjeev Sharma, and Alka Gupta. "Comparison of Effectiveness of Ropivacaine (0.5 %) with Fentanyl, and Bupivacaine (0.5 %) with Fentanyl, in Spinal Anaesthesia in Lower Limb and Lower Abdominal Surgeries." Journal of Evidence Based Medicine and Healthcare 7, no. 48 (2020): 2836–40. http://dx.doi.org/10.18410/jebmh/2020/581.

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BACKGROUND We wanted to compare the efficacy of motor and sensory blockade in lower limb and lower abdomen surgeries achieved by ropivacaine-fentanyl and bupivacainefentanyl combinations administered intrathecally. METHODS A prospective, randomized [block randomization], interventional, comparative study was conducted on 116 American Society of Anesthesiologists physical status I – II patients. They were randomly divided into two groups of 58 patients each, to receive either 3 mL of 15 mg of 0.5 % ropivacaine with 25 mcg fentanyl [group RF] or 3 mL of 15 mg of 0.5 % bupivacaine with 25 mcg fen

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Kour, Loveleen, and Mushtaq Ahmed Wani. "Comparison of thoracic vs lumbar spinal anaesthesia fo orthopaedic surgeries." International Journal of Research in Medical Sciences 7, no. 6 (2019): 2323. http://dx.doi.org/10.18203/2320-6012.ijrms20192521.

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Background: Thoracic spinal anaesthesia has emerged as one of the most promising anaesthetic techniques in the recent times. On the other hand, lumbar approach has been the conventional choice for orthopaedic surgeries since the advent of spinal anaesthesia. This study aimed at determining which approach is better suited for orthopaedic surgeries.Methods: Total 60 patients scheduled for orthopaedic surgeries were divided into two groups : group T and group L. Group T patients were given thoracic spinal anaesthesia at the T9-T10 / T10-T11 interspace using 1.5 ml of hyperbaric bupivacaine 0.5% (

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Chungkrang, Dhriti, Mohandeep Kaur, and Priyanka Singh. "Comparison of the Effects of Epidural Clonidine and Fentanyl on Spinal Anaesthesia in Lower Abdominal and Lower Limb Surgeries – A Randomised Controlled Study from Delhi, India." Journal of Evolution of Medical and Dental Sciences 10, no. 22 (2021): 1698–702. http://dx.doi.org/10.14260/jemds/2021/351.

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BACKGROUND Addition of epidural adjuvants like opioids or α2-adrenoreceptor agonists can enhance the effectiveness of local anaesthetics for surgical procedures on lower abdomen, pelvis, and lower limbs, by intensifying the block and prolonging the duration of analgesia. We wanted to compare the duration of spinal blockade (sensory and motor) and the degree of analgesia between epidural clonidine and fentanyl before giving spinal anaesthesia. METHODS A prospective double blind randomized comparative study was conducted among 100 patients (18 - 65 years) scheduled for elective lower abdomen and

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Indira, P., V. Sai Divya, Rajola Raghu, and Sadhana Roy. "Comparision of dexmedetomidine and fentanyl as adjuvants to 0.5% hyperbaric bupivacaine in spinal anesthesia in elective lower abdominal surgeries." Indian Journal of Clinical Anaesthesia 8, no. 2 (2021): 257–64. http://dx.doi.org/10.18231/j.ijca.2021.049.

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Spinal anesthesia has become most commonly used and choice of anaesthesia for surgeries on lower half of body after first planned spinal anaesthesia for surgery in man was administered by August Bier (1861–1949) on 16 August 1898, in Kiel(1), Germany. Coadministration of adjuvant drugs improve the quality and duration of anesthesia and analgesia and patient safety. To compare effects of Dexmedetomidine and Fentanyl as adjuvants to 3ml of 0.5% heavy bupivacaine injected intrathecally, in lower abdominal surgeries. Prospective randomized comparative study. The study was approved by ethics commit

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Bhat, Pai, Gayatri Kamat, Raikar Pai, Sancheeta Betkar, Fernandes Danika, and Siddhi Desai. "Comparison of addition of fentanyl or clonidine to Intrathecal bupivacaine versus Intrathecal bupivacaine alone for lower limb surgeries in elderly patients: A prospective, randomised study: Intrathecal fentanyl/clonidine ± bupivacaine for surgery in elderly." Serbian Journal of Anesthesia and Intensive Therapy 45, no. 3-4 (2023): 57–65. http://dx.doi.org/10.5937/sjait2304057b.

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Orthopaedic long bone fracture surgeries in elderly patients have their own inherent risks during anaesthesia. We aimed to compare the effect of adding clonidine or fentanyl to low dose intrathecal bupivacaine as opposed to intrathecal bupivacaine alone. Materials and methods: A prospective, double-blind study was conducted in ninety elderly patients undergoing lower limb surgery under spinal anaesthesia. After randomly allocating the patients to three groups, Group BC [Bupivacaine + Clonidine]: 9 mg bupivacaine (0.5%) + clonidine 15 µg + saline, Group BF [ Bupivacaine + Fentanyl] : 9 mg bupiv

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Kararmaz, A., S. Kaya, S. Turhanoglu, and M. A. Ozyilmaz. "Low-dose bupivacaine-fentanyl spinal anaesthesia for transurethral prostatectomy." Anaesthesia 58, no. 6 (2003): 526–30. http://dx.doi.org/10.1046/j.1365-2044.2003.03153.x.

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Desai, Devyani, Pinal Bumiya, MR Upadhyay, and Ambarish Vashishtha. "Spinal anesthesia with low dose bupivacaine and fentanyl for femur surgeries in elderly patients." Journal of Anesthesia and Critical Care: Open access 11, no. 2 (2019): 60–64. http://dx.doi.org/10.15406/jaccoa.2019.11.00412.

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Background and objectives: Decreasing the dose of intrathecal Bupivacaine may be useful to provide surgical anaesthesia with less hemodynamic disturbances especially in elderly patients but may be associated with inadequate anaesthesia for orthopaedic surgeries to perform. This can be overcome by adding Fentanyl to it. Materials and method: 60 elderly patients of American Society of Anaesthesiologists (ASA) grade II, scheduled for femur surgeries were randomly assigned to one of the two groups. Group B:(n=30) patients receiving Bupivacaine (0.5%) heavy 2.5ml (12.5mg) and Group BF:(n=30) patien

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Kour, Loveleen, and Madan Lal Katoch. "Comparison of levobupivacaine vs bupivacaine in thoracic spinal anaesthesia for laparoscopic cholecystectomies." International Journal of Research in Medical Sciences 7, no. 12 (2019): 4568. http://dx.doi.org/10.18203/2320-6012.ijrms20195520.

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Background: Levobupivacaine is the pure S enantiomer of racemic bupivacaine. It is a long acting variant that is less toxic to the heart and central nervous system. It has gained relevance and popularity in the modern anaesthetic practice. Thoracic spinal anaesthesia has been shown to an effective and safe anaesthetic approach for a varied spectrum of surgeries including laparoscopic cholecystectomies. Incorporation of epidural catheter adds flexibility and the provision of postoperative analgesia. To adopt thoracic combined spinal epidural anaesthesia for laparoscopic cholecystectomies was ch

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Parveen, Gafla. "Comparison of Effect of Intrathecal Fentanyl 25µg with 0.5% Hyperbaric Bupivacaine and Only 0.5% Hyperbaric Bupivacaine." International Journal of Clinical Anesthesia and Research 9, no. 1 (2025): 017–22. https://doi.org/10.29328/journal.ijcar.1001029.

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Background: To enhance the duration of sensory anaesthesia and to prolong the duration of post-operative pain relief during spinal anaesthesia, various adjuvants have been tried along with local anaesthetic agent. The present study was undertaken to evaluate and compare the onset and duration of sensory block, motor block and duration of post-operative pain relief by using intrathecal 0.5% Hyperbaric bupivacaine with fentanyl 25µg versus only 0.5% Hyperbaric bupivacaine selected groups. Methods: We enrolled 70 ASA Ι & ΙΙ patients undergoing surgeries below umbilicus level for our Prospecti

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Koribilli, Harish Kumar, Singh Manpreet, and Kaur Sukhmanpreet. "A Comparative Study of Efficacy of Intrathecal Levobupicaine and Bupivacaine for Caesarean Section." International Journal of Pharmaceutical and Clinical Research 15, no. 2 (2023): 747–51. https://doi.org/10.5281/zenodo.12819128.

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<strong>Introduction:</strong> A balancing method for caesarean birth is spinal anaesthesia. It provides total muscle relaxation and quick onset of anaesthesia. <strong>Objective:</strong> To evaluate and contrast the beginning, length, neonatal outcome, cardiovascular parameters, and adverse medication reactions. <strong>Material and Methods:</strong> It was a double-blind, prospective study. There were enrolled a total of 60 patients, 30 in each group. 8.5 mg of isobaric levobupivacaine and 15 g μg of fentanyl were administered to Group A, and 8.5 mg of hyperbaric

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Gupta, Palak. "Comparative study of postoperative analgesia intrathecal addition of fentanyl versus clonidine in lower limb surgeries." MedPulse International Journal of Anesthesiology 18, no. 2 (2021): 83–87. http://dx.doi.org/10.26611/10151825.

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Background: Local anesthetic drugs like bupivacaine are commonly used in spinal anesthesia for lower limb surgeries but the duration of spinal anaesthesia is very short. However, the duration of action of bupivacaine in spinal anaesthesia can be prolonged by using adjuvants such as midazolam, opioids, neostigmine, dexmedetomidine and clonidine. The present study is being undertaken to evaluate and compare the effects of clonidine and fentanyl as intrathecal adjuvants to hyperbaric bupivacaine in patients undergoing lower limb orthopaedic surgery. Material and Methods: Present study was conduct

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Barkshire, K., R. Russell, J. Burry, and M. Popat. "A comparison of bupivacaine-fentanyl-morphine with bupivacaine-fentanyl-diamorphine for caesarean section under spinal anaesthesia." International Journal of Obstetric Anesthesia 10, no. 1 (2001): 4–10. http://dx.doi.org/10.1054/ijoa.2000.0718.

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Shrestha, Bibhush, Subhash Prasad Acharya, and Amatya Roshana. "Comparison of intrathecal bupivacaine with or without fentanyl for urosurgeries." Journal of Society of Anesthesiologists of Nepal 1, no. 1 (2015): 18–21. http://dx.doi.org/10.3126/jsan.v1i1.13584.

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Introduction: Spinal anaesthesia has been widely used for urological operations because it permits early recognition of symptoms caused by overhydration, transurethral resection of prostate syndrome and bladder perforation. Short acting spinal anaesthesia may help to prevent complications associated with delayed immobilization. Our study was undertaken to examine whether adding 25?g fentanyl to bupivacaine would intensify sensory and motor block without prolonging recovery time.Materials and Methods: Ninety American Society of Anaesthesiologists physical status I and II scheduled for elective

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Chakraborty, Dr Keya, Dr Uma Mandal, Dr Swarbhanu Porel, and Dr Asis Kumar Patra. "Comparative Study of Bupivacaine-Fentanyl Versus Bupivacaine-Clonidine in Patients Undergoing Spinal Anaesthesia for Orthopedic Procedures." International Journal of Innovative Research in Medical Science 7, no. 07 (2022): 311–18. http://dx.doi.org/10.23958/ijirms/vol07-i07/1432.

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Background: There are many adjuvants used along with bupivacaine for subarachnoid block, but Fentanyl and Clonidine are commonly used as adjuvants to intrathecal bupivacaine for prolonging both sensory and motor blockade as well as postoperative analgesia in patients undergoing lower limb orthopedic surgery. Aim: The aim of the present study was to compare the effect of intrathecal Clonidine and Fentanyl as adjuvants to Bupivacaine in the subarachnoid block for lower limb orthopedic surgery. Materials and Methods: 200 patients belonging to American Society of Anaesthesiologists I or II, schedu

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Białowolska, Katarzyna, Bartosz Horosz, Agnieszka Sękowska, and Małgorzata Malec-Milewska. "Fixed Dose versus Height-Adjusted Conventional Dose of Intrathecal Hyperbaric Bupivacaine for Caesarean Delivery: A Prospective, Double-Blinded Randomised Trial." Journal of Clinical Medicine 9, no. 11 (2020): 3600. http://dx.doi.org/10.3390/jcm9113600.

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The optimal intrathecal dose of local anaesthetic for caesarean section (CS) anaesthesia is still being debated. We performed a study to compare the effectiveness and safety of spinal anaesthesia with 12.5 mg of hyperbaric bupivacaine and a dosing regimen of conventional doses adjusted to parturient height. One hundred and forty parturients scheduled for elective CS were enrolled. The fixed-dose group (FD) received a spinal block with 12.5 mg of hyperbaric bupivacaine with fentanyl, whereas the adjusted-dose group (AD) received a height-adjusted dose of bupivacaine (9–13 mg) with fentanyl. Sen

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SHIBLI, K. U., A. R. DHILLON, J. A. GOODE, et al. "Effect of intrathecal fentanyl on oxytocin secretion in pregnant women not in labour." Clinical Science 101, no. 4 (2001): 415–19. http://dx.doi.org/10.1042/cs1010415.

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We studied the effects of spinal intrathecal fentanyl on oxytocin secretion in 20healthy women prior to an elective caesarean delivery at term under spinal anaesthesia. The women were randomly allocated into two groups with respect to spinal anaesthesia. Group I (n = 10) received intrathecal bupivacaine (15mg) plus fentanyl (25μg), and Group II (n = 10) received intrathecal bupivacaine (15mg) alone, prior to caesarean section. The two groups were comparable demographically. Altogether, ten samples of 4.5ml of blood (taken every 60 s) were obtained before and ten samples were obtained after the

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Jangi, Krishan Gopal, Arti Kuldeep, Lalit Kumar Raiger, and Swati Sharma. "Evaluation of low dose hyperbaric bupivacaine with or without fentanyl in perianal surgeries: A prospective randomized double blind trial." Indian Journal of Clinical Anaesthesia 8, no. 1 (2021): 38–44. http://dx.doi.org/10.18231/j.ijca.2021.008.

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Spinal anaesthesia should be ideal for perianal surgeries due to its quick onset, reliable anaesthesia with minimal supplies making it cost-effective technique with rapid turnover time. 90 patients of ASA grade I-II scheduled for perianal surgeries divided into three groups of 30 each according to intrathecal dose of local anaesthetic: Group LB (Low dose bupivacaine): 0.6 ml of 0.5% hyperbaric bupivacaine (3mg), Group ULBF (ultralow dose bupivacaine plus fentanyl): 0.4 ml of 0.5% hyperbaric bupivacaine (2 mg) + 0.2 ml of fentanyl (10 µg) and Group ULB (ultra low dose of bupivacaine): 0.4 ml of

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Khadse, Pradnya B., Swati S. Chhatrapati, and Trupti S. Kamble. "Comparison of clonidine and fentanyl as an adjuvant to bupivacaine in unilateral spinal anaesthesia." International Journal of Research in Medical Sciences 6, no. 2 (2018): 521. http://dx.doi.org/10.18203/2320-6012.ijrms20180291.

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Background: Various adjuvants to local anaesthetics are added to improve the quality of subarachnoid block in unilateral anaesthesia during lower limb surgeries. The present study was conducted with the aim to evaluate the efficacy of combination of clonidine-bupivacaine and fentanyl-bupivacaine.Methods: This randomized study was conducted on 60 patients at tertiary care center (Topiwala National Medical College, Mumbai) for 2 years. They were divided into 2 groups consisting of 30 in each. Group BC receives Inj. bupivacaine 0.5% (hyperbaric) 7.5 mg (1.5 ml) with inj. clonidine 15 µg (0.1 ml)

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Shrestha, SK, B. Bhattarai, and R. Shah. "Comparative Study of Hyperbaric Bupivacaine Plus Ketamine Vs Bupivacaine Plus Fentanyl for Spinal Anaesthesia during Caeserean Section." Kathmandu University Medical Journal 11, no. 4 (2015): 287–91. http://dx.doi.org/10.3126/kumj.v11i4.12523.

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Background Spinal anesthesia is widely used for caesarean section due to its rapid onset, low failure rate, complete analgesia. Addition of intrathecal ketamine and opioids to local anaesthetics seems to improve the quality of block and prolong the duration of analgesia.Objectives The purpose of this study was to compare the effect of intrathecal ketamine mixed with hyperbaric bupivacaine to intrathecal fentanyl mixed with hyperbaric bupivacaine.Methods One hundred parturients ASA Grade I scheduled for elective or semiurgent caesarean section under spinal anaesthesia were randomly divided into

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Tasneem Abroo, Nafasat, and Vijaykumar T.K. "A Comparative Study of Intrathecal 0.5% Bupivacaine and 0.5% Bupivacaine with Fentanyl in Patients Undergoing." Indian Journal of Anesthesia and Analgesia 8, no. 2 (2021): 177–80. http://dx.doi.org/10.21088/ijaa.2349.8471.8221.25.

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This study was conducted to compare the effects of hyperbaric bupivacaine 0.5% alone versus hyperbaric bupivacaine 0.5% + fentanyl 25mcg in spinal anaesthesia in patients undergoing LSCS. Objective: A prospective randomised comparative study, conducted to compare the onset and duration of analgesia and hemodynamic changes, side effects like nausea, vomiting, respiratory depression, shivering, pruritis, etc. if any. Method: After institutional committee approval and obtaining written informed consent. 64 patients posted for LSCS were randomly divided into two groups with 32 patients in each gro

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Paech, M. J. "Inadvertent Spinal Anaesthesia with 0.125% Bupivacaine and Fentanyl during Labour." Anaesthesia and Intensive Care 18, no. 3 (1990): 400–403. http://dx.doi.org/10.1177/0310057x9001800319.

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Paech, M. J. "Inadvertent Spinal Anaesthesia With 0.125% Bupivacaine and Fentanyl During Labour." Obstetric Anesthesia Digest 10, no. 4 (1991): 231. http://dx.doi.org/10.1097/00132582-199101000-00058.

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Usmani, Simeen, Jamal Azmat, Farah Nafees, and Rahida Hilal. "THE RECOVERY PROFILE OF HYPERBARIC BUPIVACAINE AND BUPIVACAINE WITH FENTANYL IN SPINAL ANAESTHESIA." Journal of Evolution of Medical and Dental Sciences 8, no. 24 (2019): 1945–48. http://dx.doi.org/10.14260/jemds/2019/427.

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Satyendra, Kumar, Kumari Stuti, Kumar Bijoy, and Kumar Ashok. "Comparison of Effects of Intrathecal Clonidine and Fentanyl as Adjuvant to Hyperbaric Bupivacaine (0.5%) in Lower Abdominal Surgery." International Journal of Pharmaceutical and Clinical Research 15, no. 2 (2023): 1070–74. https://doi.org/10.5281/zenodo.12826436.

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<strong>Background:</strong> There are numerous trials combining adjuvant like fentanyl and clonidine with bupivacaine in the subarachnoid block to extend postoperative analgesia. Regarding the dosage and effectiveness of both intrathecal adjuvants, the evidence is contradictory. Some adjuvant can have their own negative consequences. Hence, the hunt for the optimum intrathecal adjuvant for bupivacaine continues. In order to compare the effectiveness, safety, and post-operative analgesia of intrathecal Fentanyl and intrathecal Clonidine as an adjuvant to hyperbaric Bupivacaine in patients

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Ahmed, Nasir Uddin, Masuda Islam Khan, Aynul Islam Khan, and AKM Akhtaruzzaman. "Low Dose Bupivacaine plus Fentanyl in Subarachnoid Block for Caesarean Section." Delta Medical College Journal 4, no. 1 (2016): 24–30. http://dx.doi.org/10.3329/dmcj.v4i1.27628.

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Background: Spinal anaesthesia induced hypotension, a common problem during caesarean section, is associated with maternal nausea and vomiting and the risk of neonatal acidosis. Low dose local anaesthetic combined with opioids spinal anaesthesia better preserves maternal haemodynamic stability, resulting in equally efficacious anaesthesia.Objectives: To investigate whether this synergistic action could be used to provide effective anaesthesia while preventing hypotension during caesarean operation.Materials and method: This prospective study included 60 pregnant mothers scheduled for caesarean

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HE, Kantharaja, Geetha S, and Kiran Kumar HY. "A Comparative Study of Intrathecal Magnesium Sulphate with or without Intrathecal Fentanyl to 0.5% Hyperbaric Bupivacaine in Parturients Undergoing Elective Lower Segment Caesarean Section." Indian Journal of Anesthesia and Analgesia 9, no. 1 (2022): 39–43. http://dx.doi.org/10.21088/ijaa.2349.8471.9122.6.

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Background: Prolongation of analgesia in Neuraxial anaesthesia is achieved by adding various adjuvants intrathecally along with local anaesthetic agent. Using two adjuvants together in lower doses will prolong the duration of analgesia without causing much side effects. Aims: To compare the efficacy and safety of Intrathecal Magnesium v/s Fentanyl with Magnesium sulphate as an adjuvant to 0.5% Bupivacaine in terms of onset and duration of Sensory and Motor Blockade and Duration of Postoperative analgesia. Material and Methods: Prospective randomized double blinded study was conducted on 70 ASA

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Kour, Loveleen, and Kuldip C. Gupta. "Comparison of effect of isobaric bupivacaine vs hyperbaric bupivacaine on haemodynamic variables in thorcic combined spinal epidural anaesthesia for laparoscopic cholecystectomies." International Journal of Research in Medical Sciences 6, no. 10 (2018): 3413. http://dx.doi.org/10.18203/2320-6012.ijrms20184056.

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Background: Regional anaesthesia has always been an attractive option for laparoscopic surgeries in patients who are not fit for general anaesthesia. Also, regional anaesthesia has certain advantages over general anaesthesia like lesser oropharyngeal morbidity, lesser blood loss and decreased chances of thrombosis. Lumbar spinal anaesthesia has been synonymous with the term regional anaesthesia for laparoscopic surgeries for quite some time now. In the light of recent works by Imbelloni and Zundert, thoracic spinal anaesthesia has been shown to be a promising alternative not only for healthy p

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Kotwani, Manish B., Kanchan Rupwate, Prashanth Shivananda, and Jyoti Magar. "Comparison between high dose hyperbaric Bupivacaine (12.5 mg) alone versus low dose hyperbaric Bupivacaine (7.5 mg) with Fentanyl (25 µg) in spinal anaesthesia for inguinal hernia surgery." International Journal of Clinical Trials 3, no. 3 (2016): 140. http://dx.doi.org/10.18203/2349-3259.ijct20162795.

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<p class="abstract"><strong>Background:</strong> For performing inguinal hernia surgeries, giving spinal anesthesia is a well known technique as it easy and provides fast onset, effective sensory and motor blockade in an awake patient. Now-a-days Bupivacaine is gaining importance as an effective spinal anaesthetic agent in combination with opioid analgesic Fentanyl to reduce the postoperative pain and side effects associated with surgery. This study aims to compare the effectiveness of intrathecal Bupivacaine alone versus combination of Bupivacaine with Fentanyl.</p>&lt

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Tuhin Vashishth and Sangeeta Varun. "Clinical Comparative Study between Fentanyl and Dexmedetomidine with Bupivacaine for Lower Limb Surgery in Spinal Anaesthesia." Academia Anesthesiologica International 5, no. 1 (2020): 126–30. http://dx.doi.org/10.21276/aan.2020.5.1.25.

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Background: Spinal anesthesia is a preferred technique of choice in infraumbilical surgeries. The spinal anesthesia effect can be improved by adding various adjuvant like Fentanyl, clonidine, dexmedetomidine. Dexmedetomidine is a highly selective alpha 2 adrenergic agonists. The aim of study to compare efficacy and safety between Dexmedetomidine and Fentanyl with Bupivacaine.Subjects and Methods:A prospective randomized, double-blind study was conducted on 100 patient by dividing them into two groups. Group D: 2.5ml (12.5mg) of 0.5% hyperbaric bupivacaine with 5mcg (0.5ml) dexmedetomidine and

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Vinay, Kumar, Kirti Shruti, and Kumar Krishna. "Comparative Study of Intrathecal Fentanyl and Buprenorphine as an Adjuvant to 0.5% Hyperbaric Bupivacaine in Spinal Anaesthesia for Lower Abdominal and Lower Limb Surgery in Adults." International Journal of Pharmaceutical and Clinical Research 15, no. 8 (2023): 1625–29. https://doi.org/10.5281/zenodo.11528837.

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<strong>Background:</strong> Neural axial blockade is the recommended type of anesthesia for lower limb procedures. Because of its quick onset, superior blockade, lower failure rates, and cost-effectiveness, spinal block is still the preferred treatment. The current study compares the effectiveness of intrathecal bupivacaine combined with buprenorphine and fentanyl in orthopaedic procedures involving the lower limbs. <strong>Method:</strong> Five patients were excluded because they did not meet the inclusion criteria out of 89 scheduled patients for lower abdomen and lower limb

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Duraiya, Gulamali, Gandhi Ravindra, and Bamaniyawala Zohara. "Comparative Analysis of Intrathecal Bupivacaine Plus Clonidine Vs Bupivacaine Plus Dexmedetomedine for Gynaecological Procedures." International Journal of Pharmaceutical and Clinical Research 15, no. 11 (2023): 596–600. https://doi.org/10.5281/zenodo.11217711.

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<strong>Background and Aim: </strong>The incorporation of adjuvants into intrathecal medications that are routinely administered is essential for the safe and effective extension of single-shot spinal blocks used in gynaecological surgery. In resource-constrained nations, where the expense of epidural anaesthesia typically prevents its use, adjuvants are frequently employed to extend the duration of regional anaesthesia. Comparing the efficacy of intrathecal bupivacaine and clonidine to that of bupivacaine and dexmedetomedine for gynaecological procedures was the purpose of the present st

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Deepak, Kumar, Nath Das Ram, and Kumar Sinha Pramod. "Clinical Characteristics of Individuals Receiving Intrathecal Bupivacaine with Clonidine or Bupivacaine with Fentanyl Spinal Anaesthesia." International Journal of Pharmaceutical and Clinical Research 13, no. 5 (2021): 446–51. https://doi.org/10.5281/zenodo.14225416.

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<strong>Aim: </strong>The aim of this study to assess the clinical characteristics of individuals receiving intrathecal bupivacaine with clonidine or bupivacaine with fentanyl spinal anaesthesia. <strong>Methods: </strong>A prospective double blind randomized controlled study was conducted in the Department of Anaesthesiology, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India, for 1 year. 100 adult patients were randomly divided on an alternative basis into two groups of 50 each. Group <strong>“</strong>A<strong>”</strong>-Bupivacaine plus

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Nirali, S. Trivedi, K. Gusai Vijaygiri, and Thacker Mandakinee. "Analysis of the Addition of Clonidine and Fentanyl Addition to the Bupivacaine for Caesarean Section." International Journal of Toxicological and Pharmacological Research 12, no. 7 (2022): 1–5. https://doi.org/10.5281/zenodo.11629691.

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<strong>Background:</strong> Intrathecal opiods enhance analgesia from subtherapeutic dose of local anesthetic and make it possible to achieve successful spinal anaesthesia using otherwise inadequate doses of local anesthetic. Hence the aim of the present study was to evaluate the effects of fentanyl and clonidine added to Bupivacaine, for caesarean section in spinal Anaesthesia. <strong>Materials & Methods: </strong>Patients were randomly allocated into 3 groups of 80 each.  A- Control Group – Injection (0.5%) Bupivacaine 1.8 ml + 0.4 ml NS, B- Study group 1 inj.

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Poudel, Hari, Surinder Nath Bawa, and Surendra Mohan Sharma. "A comparative clinical study of intrathecal hyperbaric bupivacaine with and without fentanyl for hysterectomy." Asian Journal of Medical Sciences 11, no. 2 (2020): 59–63. http://dx.doi.org/10.3126/ajms.v11i2.26548.

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Background: Spinal anaesthesia has been widely used for lower abdominal surgeries like hysterectomy.Hyperbaric bupivacaine is the most extensively used local anesthetic. Addition of fentanyl can allow the reduction in the dose of bupivacaine, increase the height and duration of sensory blockade, and reduces complications of spinal anesthesia. Aims and Objective: The aim of the study was to examine whether adding fentanyl to hyperbaric bupivacaine would increase the height of sensory blockade, accelerate the onset of sensory blockade and increase the duration of the sensory blockade.&#x0D

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