Journal articles: 'DFDBA'

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Ravi Kiran, Sunkavilli, Mohd Aijaz Ahmed, Niharika Bammidi, and Yudheera Karnam. "EVALUATION OF EFFICACY OF DEMINERALIZED FREEZE DRIED BONE ALLOGRAFT WITH AND WITHOUT PLATELET-RICH FIBRIN IN THE TREATMENT OF INTRABONY DEFECTS BY CONE BEAM COMPUTED TOMOGRAPHY: A CLINICAL AND RADIOGRAPHIC STUDY." International Journal of Advanced Research 9, no. 09 (September 30, 2021): 156–64. http://dx.doi.org/10.21474/ijar01/13389.

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Background: Eventhough the combination of DFDBA (demineralized freeze dried bone allograft) with PRF (platelet-rich fibrin) has been attempted in periodontal practice with significant results, assessment of the intrabony defect and defect bone fill largely done with two-dimensional imaging modalities. Three dimentional analysis of the intrabony defect and defect bone fill has not been attempted with cone beam computer tomography (CBCT). The present study evaluated the efficacy of DFDBA with and without PRF in the treatment ofintrabony defects by CBCT. Methods: 60 defects in systemically healthy patients ranging from 18 to 50 years of age will be included in the study.30 defects were treated with PRF+DFDBA and 30 defects were treated with DFDBA alone. The study will include the assessment of clinical parameters involving probing depth (PD), relative attachment level(RAL), full mouth bleeding scores(FMBS),plaque index and gingival index from baseline to 3 , 6, 9 months. Hard tissue changes will be assessed radiographically by evaluating defect fill and defect resolution by CBCT at baseline& 9 months. Results: The results of the present study are statistically significant in both groups in terms of clinical and radiographical parameters (P < 0.001). In inter-group comparison, there was a statistically significant greater PD reduction and attachment gain while there was not significant reduction in terms of PI, GI, FMBS, defect fill and defect resolution in DFDBA+ PRF group. Conclusion: DFDBA along with PRF failed to provide additional value in terms of defect fill and defect resolution over DFDBA alone.

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Simon, B. I., A. L. Zatcoff, J. J. W. Kong, and S. M. O’Connell. "Clinical and Histological Comparison of Extraction Socket Healing Following the Use of Autologous Platelet-Rich Fibrin Matrix (PRFM) to Ridge Preservation Procedures Employing Demineralized Freeze Dried Bone Allograft Material and Membrane." Open Dentistry Journal 3, no. 1 (May 20, 2009): 92–99. http://dx.doi.org/10.2174/1874210600903010092.

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Background: The healing potential of platelet growth factors has generated interest in using Platelet-Rich Plasma (PRP) in ridge preservation procedures. A canine study was performed to determine if extraction sites treated with platelet-rich fibrin matrix (PRFM) exhibit enhanced healing compared to sites treated with non-viable materials. Methods: Four dog’s extraction sockets were treated individually with PRFM, PRFM and membrane, Demineralized Freeze-Dried Bone Allograft (DFDBA) and membrane, PRFM and DFDBA, and untreated control. Treatment sequencing permitted clinical and histologic evaluation of healing at 10 days, 2, 3, 6 and 12 weeks. Results: Healing was more rapid in the PRFM and PRFM and membrane sites. By 3 weeks those sockets had osseous fill. Sites containing DFDBA had little new bone at 6 weeks. By 12 weeks those sockets had osseous fill but DFDBA particles were still noted in coronal areas. Conclusions: PRFM alone may be the best graft for ridge preservation procedures. Advantages: faster healing, and elimination of disadvantages involved in using barrier membranes.

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Kadkhodazadeh, Mahdi, Alireza Fathiazar, Zahra Yadegari, and Reza Amid. "Comparison of osteopromoting ability of human tooth powder with the demineralized freeze-dried bone allograft, a bovine xenograft, and a synthetic graft: An in vitro study." Journal of Advanced Periodontology & Implant Dentistry 12, no. 1 (April 26, 2020): 19–23. http://dx.doi.org/10.34172/japid.2020.005.

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Background. The present study aimed to evaluate the osteopromoting ability of human tooth powder and compare it to a bovine xenograft, a synthetic material, and the DFDBA allograft. Methods. In this in vitro study, 30 teeth without caries, inflammation, and infection, which had been extracted for orthodontic reasons, were collected. The crowns were removed, pulpectomy was carried out, and the samples were ground to a powder with particles <500 µm. Osteoblast-like cells of MG-63 were cultured with the tooth powder, Cerabone, DFDBA, and Osteon II. Cell proliferation was assessed by the MTT assay at 24- and 72-hour intervals. The alizarin red test was carried out after three and five days. The alkaline phosphatase level was measured after 24, 48, and 72 hours to assess the osteoblastic activity. The results were analyzed with one-way ANOVA. Results. According to the MTT assay, all the materials exhibited a higher proliferation rate than the control group in 24 hours. In 72 hours, DFDBA had the lowest cell proliferation rate at concentrations of 40 and 80 mg/mL. DFDBA and the positive control group were able to create calcified nodules by the alizarin red test. At the 48- and 72-hour intervals, DFDBA had the lowest alkaline phosphatase activity at a concentration of 40 mg/mL. At the 72-hour interval, bovine xenograft had the highest alkaline phosphatase level, followed by the synthetic material and tooth powder. Conclusion. The tooth powder was able to increase cell proliferation in comparison with the bovine xenograft, the synthetic graft, and the DFDBA. However, its osteopromoting ability was less than that of the osteogenic materials.

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El-dien, Asma M. Sarag, Shereen Fathy, and Yasmine Alaa El-din. "Potential Bone Regenerative Effects of DFDBA, Simvastatin and Platelet Rich Fibrin, Radiographically and Histologically of Intra-Bony Periodontal Defects in White New Zealand Rabbits." Open Access Macedonian Journal of Medical Sciences 9, no. D (April 11, 2021): 72–80. http://dx.doi.org/10.3889/oamjms.2021.5848.

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AIM: This study aimed to evaluate and to compare the regenerative power of simvastatin, Demineralized Freeze-Dried Bone Allograft (DFDBA) allograft, platelets rich Fibrin (PRF), and a combination of these materials radiographically and histologically in the intra-bony periodontal defects in white New Zealand rabbits. MATERIALS AND METHODS: This study was conducted on 54 defects in 27 adult male rabbits (n = 27) which were divided into three groups according to the follow-up preplanned scheduled for 1, 2, and 3 weeks. The selected materials were induced as following: A=DFDBA, B=Simvastatin, C= PRF, D=A+C, E=B+C, and F=negative (control group). The intra-bony periodontal defects were induced as the form of one osseous wall defect of 10 mm height, 4 mm depth between the first and the second molars. Then, samples were prepared for histological evaluation. Radiographic assessment was done using computed tomography radiography which was carried at different time intervals as the following baseline, 1, 2, and 3 weeks later. Statistical analysis was performed using ANOVA. RESULTS: After evaluating the results, macroanatomy, radiographically, and histologically, it is thus confirmed that DFDBA allograft combined with PRF create the best bone regenerative results, followed by DFDBA, Simvastatin, simvastatin+ PRF, control group, and finally PRF. CONCLUSION: All of the materials examined in this study showed different percentage in terms of bone density and bone regenerative effects. However, the best results for bone density of the DFDBA + PRF group were recorded after 3 weeks. Thus, the study concludes that a combination of DFDBA + PRF reflects the best properties of both materials in terms of bone density results of the defect. Such results are particularly significant for the selection of bone regeneration materials, and generally, for periodontal regeneration.

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Anggraini, Netta, Sri Pramestri Lastianny, and Al Sri Koes Soesilowati. "Differences in results of infrabony pocket treatment with addition of platelet rich fibrin and platelet rich plasma gel in DFDBA bone graft." Majalah Kedokteran Gigi Indonesia 1, no. 1 (December 2, 2019): 29. http://dx.doi.org/10.22146/majkedgiind.37423.

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Treatment of infrabony pocket makes use of bone graft material demineralized freeze dried bone allograft (DFDBA) from different individuals which has undergone demineralization process and it is osteoinductive. Enhancement of growth factor was done by adding platelet rich fibrin (PRF) and platelet rich plasma (PRP). PRP is activated with an addition of calcium chloride CaCl2) to form gel. The method used to apply the bone grafting material is open flap debridement OFD). This research aimed to reveal the differences in the results of infrabony pocket treatment using PRF and PRP gel with an addition of DFDBA. The sample was taken from 20 infrabony pocket points divided into 2 groups, 10 infrabony pocket were treated with OFD+DFDBA+PRF and the other were treated with OFD+DFDBA+PRP gel. Pocket depth (PD) was measured on the baseline and the first and third month after treatment. Alveolar bone height was measured using cone beam computed tomography (CBCT) radiograph on the baseline to the third month after treatment. The results of this research showed that there was difference in the results of infrabony pocket treatment using PRF and PRP gel with an addition of DFDBA which could be observed from a reduction in PD from the baseline, month 1 and month 3 as well as reduction in alveolar bone height from the baseline to month 3. This research concluded that infrabony pocket treatment PRF application yields better results than PRP gel application in terms of PD and alveolar bone height reduction.

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Turonis, James W., James C. McPherson, Michael F. Cuenin, Steven D. Hokett, Mark E. Peacock, and Mohamed Sharawy. "The Effect of Residual Calcium in Decalcified Freeze-dried Bone Allograft in a Critical-sized Defect in the Rattus norvegicus Calvarium." Journal of Oral Implantology 32, no. 2 (April 1, 2006): 55–62. http://dx.doi.org/10.1563/780.1.

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Abstract Demineralized freeze-dried bone allograft (DFDBA), a widely used graft material in periodontal regenerative procedures, is processed with hydrochloric acid in the attempt to expose proteins located within the bone matrixes that are capable of inducing new bone formation. However, the degree of DFDBA demineralization varies between tissue banks, which may have an effect on clinical regeneration. This study uses the critical-sized defect (CSD) model to evaluate the wound-healing response to the residual calcium of donor bone. If the percentage of residual calcium in a graft were demonstrated to significantly enhance wound healing, then periodontal patients may benefit from further standardization of human-allograft processing. Sixty adult, male, Harlan Sprague-Dawley rats (Rattus norvegicus) were randomly and equally divided into 4 test groups (ie, DFDBA at 1%, 2%, and 3% to 6% residual calcium levels and FDBA at 23% residual calcium) and a control group (no allograft). An 8-mm-diameter craniotomy was made in the rat calvarium, and polytetrafluoroethylene membranes with pore sizes of 0.50 μm were placed intracranially and ectocranially. Treatment materials were carefully placed into the CSD with a new sterilized dental amalgam carrier. Tetracycline hydrochloride was injected intraperitoneally for labeling new bone growth, and animals were euthanized 12 weeks postsurgery. As a result, histomorphometric bone fill at 12 weeks showed a statistically significant increase in the 2% DFDBA group as compared to all other groups. The authors conclude that a 2% residual calcium level in human DFDBA appears to significantly (P ≤ .05) enhance osseous wound healing in the rat calvarium.

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Amelia, Frizky, Basril Abbas, Darmawan Darwis, Sri Estuningsih, and Deni Noviana. "Effects of bone types, particle sizes, and gamma irradiation doses in feline demineralized freeze-dried bone allograft." August-2020 13, no. 8 (2020): 1536–43. http://dx.doi.org/10.14202/vetworld.2020.1536-1543.

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Background and Aim: Fracture cases significantly increase recently, demanding high quality of bone graft materials. This research aimed to evaluate the effects of bone types, particle sizes, and gamma irradiation doses on morphological performance and cell viability of feline demineralized freeze-dried bone allograft (DFDBA) through an in vitro study. Materials and Methods: Feline DFDBA derived from feline cortical and cancellous long bones was processed into four different sizes: Group A (larger than 1000 μm), B (841-1000 μm), C (420-840 μm), and D (250-419 μm) for each type of bones. The materials were then irradiated with two doses of gamma rays, 15 and 25 kGy, resulting in 16 variants of feline DFDBA. The surfaces of each material were then observed with the scanning electron microscope (SEM). The in vitro evaluation of feline DFDBA was then performed using 3-(4,5-dimethythiazol-2)-2,5-diphenyltetrazolium bromide (MTT) assay with calf pulmonary artery endothelial cells. Results: The MTT assay results showed that the lowest inhibition rate (14.67±9.17 %) achieved by feline DFDBA in Group A derived from cortical bones irradiated with 15 kGy. Group D generally showed high inhibition rate in both cancellous and cortical bones, irradiated with either 15 or 25 kGy. The SEM results showed that cancellous and cortical bones have numerous macropores and micropores structure in 170× and 3000×, respectively. Conclusion: The material derived from cortical bones in Group A (larger than 1000 μm in particle size) irradiated with 15 kGy is the best candidate for further development due to its abundance of micropores structure and ability in preserving the living cells.

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Maksmara, Heru. "Remodeling Tulang Alveolar untuk Reimplantasi dan Transplantasi Gigi Anterior pada Kehilangan Tulang Hebat Paska Trauma." Majalah Kedokteran Gigi Indonesia 18, no. 1 (June 30, 2011): 77. http://dx.doi.org/10.22146/majkedgiind.16483.

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Latar Belakang. Remodeling tulang alveolar berguna untuk memperbaiki kehilangan struktur jaringan pendukung gigi yang hebat pada reimplantasi dan transplantasi gigi anterior, supaya gigi anterior yang terlepas dari soketnya paska trauma dapat di implantasi. Bahan cangkok tulang untuk remodeling tulang alveolar yang digunakan berjenis demineralized freeze-dried bone allograft (DFDBA). Tujuan Penulisan Laporan Kasus. Melaporkan keberhasilan menanam gigi tetap ditempatnya dengan teknik remodeling tulang dengan penambahan DFDBA agar struktur jaringan pendukung gigi yang hilang kembali normal. Penatalaksanaan. Pasien paska trauma, dalam keadaan tidak sadar selama 7 hari di ruang rawat intensif dan dirawat selama 7 hari di bangsal. Pasien mengalami trauma dan kehilangan tulang penyangga gigi yang hebat, pada gigi anterior bawah. Tiga gigi anterior mengalami kegoyahan 4° dan dua gigi hilang. Hilangnya dua gigi mengakibatkan area edentulous besar, sehingga perlu di lakukan transplantasi satu gigi. Untuk memperkecil edentulous dilakukan penambahan lebar mahkota gigi menggunakan composite light curing. Setelah pencabutan gigi, semua gigi yang akan di implant dilakukan perawatan saluran akar gigi dan disterilkan. Flap operasi dilakukan untuk menata serpihan tulang dan menilai besarnya trauma, daerah luka dibersihkan dengan lIarutan salin. Splinting semua gigi yang akan di implant menggunakan arch bar dan kawat. Penambahan bahan cangkok tulang DFDBA pada daerah operasi. Menjahit daerah operasi ke korona gigi dan ditutup pack. Setelah 6 bulan operasi dua gigi tidak men gal ami kegoyahan, dua gigi lain mengalami kegoyahan 2°, 12 bulan tiga gigi tidak mengalami kegoyahan dan hanya satu gigi transplantasi yang mengalami kegoyahan 1°. Re-entry operasi dilakukan untuk remodeling tulang bertambah baik. Setelah 6 bulan paska re-entry operasi, gigi yang di transplantasi tidak mengalami kegoyahan. Sehingga splint dapat dilepas. Kesimpulan. Remodeling tulang pada teknik reimplantasi dan transplantasi gigi gigi disertai kehilangan tulang yang hebat dapat dilakukan paska trauma dengan penambahan bahan cangkok tulang - DFDBA, sehingga gigi anterior dapat berfugsi kembali mengunyah makanan.

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Lima, Julio Leonardo de Oliveira, Daniel Isaac Sendyk, Wilson Roberto Sendyk, Cristiane Ibanhes Polo, Luciana Correa, and Maria Cristina Zindel Deboni. "Growth Dynamic of Allogeneic and Autogenous Bone Grafts in a Vertical Model." Brazilian Dental Journal 29, no. 4 (August 2018): 325–34. http://dx.doi.org/10.1590/0103-6440201801994.

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Abstract Several techniques have been proposed for vertical bone regeneration, and many of them use bone autogenous and allogeneic grafts. The purpose of this study was to compare demineralised freeze-dried bone allografts (DFDBA), fresh-frozen (FF) allografts, autogenous bone grafts to find differences between volumetric and histological quantity of bone formation and vertical bone growth dynamic. A vertical tissue regeneration bone model was performed in rabbit calvarias under general anaesthesia. Four hollow cylinders of pure titanium were screwed onto external cortical bone calvarias in eight rabbits. Each one of the cylinders was randomly filled with one intervention: DFDBA, FF, autogenous bone, or left to be filled with blood clot (BC) as control. Allogeneic grafts were obtained from a ninth animal following international standardised protocols for the harvesting, processing, and cryopreservation of allografts. Autogenous graft was obtained from the host femur scraping before adapting hollow cylinders. Animals were euthanized at 13 weeks. Vertical volume was calculated after probe device measurements of the new formed tissue inside the cylinders and after titanium cylinders were removed. Histomorphometry and fluorochrome staining were used to analyse quantity and dynamic of bone formation, respectively. Results showed that DFDBA and fresh-frozen bone improved the velocity and the quantity of bone deposition in distant portions of the basal plane of grafting. Remaining material in allograft groups was more intense than in autogenous group. Both allografts can be indicated as reliable alternatives for volume gain and vertical bone augmentation.

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Ramadhany, Eka Pramudita, Al Sri Koes Soesilowati, and Sri Pramestri Lastianny. "Effect of sandwich bone augmentation using hydroxyapatite and demineralized freeze- dried bone on infrabony pocket treatment." Majalah Kedokteran Gigi Indonesia 5, no. 3 (February 27, 2020): 114. http://dx.doi.org/10.22146/majkedgiind.37427.

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Periodontitis is periodontal inflammation in response to plaque bacterial antigens, causing damage to periodontal ligament and alveolar bone resorption. Bone graft material combination i.e. demineralized freeze-dried bone allograft (DFDBA) and hydroxyapatite (HA) using sandwich bone augmentation (SBA) method will support each other and will be beneficial to be used as a scaffold. The body takes long time to resorb HA so this could complement DFDBA which is more easily dissolved. This study aimed to reveal the effect of bone graft addition using SBA method on the treatment of infrabony pocket with open flap debridement in terms of probing depth, relative attachment loss, alveolar bone height, and density. This study was carried out to 20 infrabony pockets, where 10 of them were treated using open flap debridement with HA addition, while the other 10 groups were treated using open flap debridement with DFDBA and HA using SBA method. Probing depth and relative attachment loss were measured on days 0, 30 and 90. Bone height and density were measured using cone-beam computed tomography (images on day 0 and 90). The study showed that probing depth reduction on SBA group was greater than HA group. There were significant differences in probing depth and relative attachment loss examinations. However, bone height and bone density reduction did not show any significant difference. The conclusion from this study is open flap debridement using SBA method yields better regeneration in terms of probing depth and relative attachment loss than open flap debridement with HA addition. There is no difference in bone height and bone density between the two groups.

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Simion, M., P. Trisi, and A. Piattelli. "GBR with an e-PTFE membrane associated with DFDBA." Implant Dentistry 6, no. 2 (1997): 139. http://dx.doi.org/10.1097/00008505-199700620-00033.

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Vaid, Tithi, Santosh Kumar, Rupal Mehta, Sujay Shah, Surabhi Joshi, Susmita Bhakkand, and Tanvi Hirani. "Clinical and radiographic evaluation of demineralized freeze-dried bone allograft with concentrated growth factor versus concentrated growth factor alone in the treatment of intrabony defects." Medicine and Pharmacy Reports 94, no. 2 (April 29, 2021): 220–28. http://dx.doi.org/10.15386/mpr-1718.

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Background. Periodontal disease is one of the major causes of alveolar bone loss. There are various ways of regenerating the lost bone, i.e. guided tissue regeneration, bone grafts, and growth factors. In this purview, it becomes immensely important for a clinician to decide the best modality of treatment. In this study, we compared the effect of demineralized freeze-dried bone allograft (DFDBA) in combination with concentrated growth factors (CGF) verses CGF alone. Methods. This double-blind, split-mouth study was conducted on ten patients with two comparable bilateral intrabony defects. Each pair of defects was randomly treated by DFDBA + CGF or CGF alone. Clinical parameters such as plaque index (PI), modified gingival index (MGI), pocket probing depth (PPD), and relative attachment level (RAL) were recorded at baseline, three months, and six months. In addition, radiograph with grids was also taken at baseline and six months. The paired t-test was used to compare the pre- and post-treatment values and the unpaired t-test was used to compare the test and control group. Results. The PI score decreased significantly from baseline to six months. Similarly, the mean MGI score decreased significantly from baseline to six months. The intragroup comparison showed that there was a significant reduction in PPD in both the test and control group. However, the intergroup comparison showed that the reduced pocket depth was not significant. The intragroup radiographic comparison showed that there was the significant formation of bone in both the test and control group but inter-group showed that the formation of bone among both the group were non-significant. Conclusion. Radiographic and clinical outcomes of this study concluded that post six months, both groups demonstrated significant improvement in clinical and radiographic parameters. However, the addition of DFDBA to CGFs did not give any additional benefits.

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Erdemir, Ebru Olgun, Meltem Karsiyaka Hendek, H. Gencay Keceli, and Teoman Z. Apan. "Crevicular fluid levels of interleukin-8, interleukin-17 and soluble intercellular adhesion molecule-1 after regenerative periodontal therapy." European Journal of Dentistry 09, no. 01 (January 2015): 060–65. http://dx.doi.org/10.4103/1305-7456.149644.

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ABSTRACT Objective: The aim of this study is to evaluate the influence of regenerative periodontal therapy on clinical parameters and interleukin-8 (IL-8), IL-17 and soluble intercellular adhesion molecule-1 (sICAM-1) levels in gingival crevicular fluid (GCF) of subjects with chronic periodontitis (CP). Materials and Methods: Fifteen patients received demineralized freeze-dried bone allograft (DFDBA) surgically to the site of infrabony defect. Clinical periodontal indices were recorded, and GCF samples were collected at baseline and at the 6th and the 9th month after the surgery. Results: Except plaque index, all clinical parameters improved following surgery (P < 0.05). The volume of GCF diminished from baseline to follow-up periods (P < 0.05). However, no effect was observed on the total amount of IL-8, IL-17 and sICAM-1 in GCF. Conclusion: DFDBA improved clinical outcome in CP subjects and was effective on decreasing the volume of GCF, but no effect was determined on IL-8, IL-17 and sICAM-1. Findings did not indicate a direct relationship between biochemical parameters and periodontal healing after demineralized freeze-dried bone grafting.

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Aspriello, Simone Domenico, Luigi Ferrante, Corrado Rubini, and Matteo Piemontese. "Comparative study of DFDBA in combination with enamel matrix derivative versus DFDBA alone for treatment of periodontal intrabony defects at 12 months post-surgery." Clinical Oral Investigations 15, no. 2 (January 7, 2010): 225–32. http://dx.doi.org/10.1007/s00784-009-0369-y.

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Sulijaya, Benso, Sandra Olivia Kuswandani, and Yuniarti Soeroso. "Contemporary guided bone regeneration therapy for unaesthetic anterior peri-implantitis case." Dental Journal (Majalah Kedokteran Gigi) 49, no. 4 (December 31, 2016): 181. http://dx.doi.org/10.20473/j.djmkg.v49.i4.p181-184.

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Background: Dental implant is one of an alternative solutions reconstruction therapy for missing teeth. Complication of dental implant could occurs and leading to implant failure. In order to restore the complication, surgical treatment with guided bone regeneration (GBR) is indicated. The potential use of bone substitutes is widely known to be able to regenerate the bone surrounding the implant and maintain bone volume. Purpose: The study aimed to demonstrate the effectiveness of implant-bone fully coverage by using sandwich technique of biphasic calcium phosphate (BCP) and demineralized freeze-dried bone allografts (DFDBA) bone substitutes combined with collagen resorbable membrane. Case: A 24-year-old male came with diagnosis of peri-implantitis on implant #11. Clinical finding indicated that implant thread was exposed on the labial aspect. Case management: After initial therapy including oral hygiene improvement performed, an operator did a contemporary GBR to correct the defect. Bone graft materials used were 40% β-tri calcium phosphate (β-TCP)-60% hydroxyapatite (HA) on the outer layer and DFDBA on the inner layer of the defect. Resorbable collagen membrane was used to cover the graft. Conclusion: GBR with sandwich technique could serve as one of the treatment choices for correcting an exposed anterior implant that would enhance the successful aesthetic outcome.

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Grageda, Edgar, Jaime L. Lozada, Phillip J. Boyne, Nicholas Caplanis, and Paul J. McMillan. "Bone Formation in the Maxillary Sinus by Using Platelet-rich Plasma: An Experimental Study in Sheep." Journal of Oral Implantology 31, no. 1 (February 1, 2005): 2–17. http://dx.doi.org/10.1563/0-692.1.

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Abstract Recently, platelet-rich plasma (PRP) has been proven to be an effective regeneration adjunct when combined with autogenous bone in the reconstruction of mandibular defects. However, little is known about the effect of PRP when combined with a bone allograft in the maxillary sinus. The purpose of this study was to quantitatively evaluate the ability of PRP to enhance bone regeneration in the maxillary sinus of sheep when combined with demineralized freeze-dried bone allograft (DFDBA) and cortical cancellous freeze-dried bone allograft (CCFDBA). Ten sheep were selected for bilateral sinus augmentation DFDBA + CCFDBA + PRP (test) and DFDBA + CCFDBA (control). Five were sacrificed at 3 months and the other 5 at 6 months. Hematology tests were performed for platelet count, and histology slides were obtained for histomorphometric analysis taking 2 measures of interest: total area (square millimeters) and percentage of bone fill. Student t tests showed no significant difference between test and control groups for total area (P > .25) and percentage of bone fill (P > .80) at either 3 or 6 months. The control group showed no statistical difference for total area (P < .095) and percentage of bone fill (P < .60) between 3- and 6-month healing times. The test group, however, showed a significant increase in total area (P < .025) but not in percentage of bone fill (P < .40) for the 2 healing periods. When the treatments were compared for interactions within the animal model, no clear tendency was evident for the test group to perform in relation to the control group regarding total area (r = .766, P < .01). A moderate tendency existed between the percentages of bone filled (r = .824, P < .005). Platelet-rich plasma showed higher platelet count than did the whole blood (2 to 5 times). However, no correlation was found between the log ratio and the bone measures. Within the limitations of this study, PRP failed to enhance or accelerate bone regeneration in the maxillary sinus of sheep when combined with bone allograft.

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Charde, Priti, Kaustubh S. Thakare, Manohar Laxman Bhongade, Aleksa Markovic, and Aniruddha M. Deshpande. "Reconstruction of Interimplant Papilla by Demineralized Freeze-dried Bone Allograft Block Fixed by Titanium Screw in Maxillary Esthetic Zone." Journal of Contemporary Dental Practice 21, no. 11 (2020): 1205–9. http://dx.doi.org/10.5005/jp-journals-10024-2960.

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ABSTRACT Aim To evaluate effectiveness of demineralized freeze-dried bone allograft (DFDBA) block fixed by titanium screw for reconstructing interimplant papilla in maxillary esthetic zone during one-stage early loading multiple implant procedure. Materials and methods A total of 20 implants were placed in 10 systemically healthy patients (2 implants per patient) for replacement of multiple teeth by early loading one-stage implants along with interimplant papilla reconstruction using DFDBA block fixed by titanium screw. At the baseline, 6 months, and at 1 year, clinical measurements (interimplant papillary height measurement, papilla contour) and radiographic measurements were recorded. Results At 1 year, mean gain in interimplant vertical crestal bone was 1.7 mm, and complete reconstruction of the papilla was observed in 90% cases. Conclusion Demineralized freeze-dried bone allograft block fixed by titanium screw for reconstruction of interimplant papilla in maxillary esthetic zone during one-stage early loading multiple implant procedure is effective. Clinical significance Presence of interimplant papilla is of utmost importance for esthetically successful implant-supported restoration in the anterior region. This technique leads to reconstruction of interimplant papilla, thus providing esthetic appearance. How to cite this article Charde P, Thakare KS, Bhongade ML, et al. Reconstruction of Interimplant Papilla by Demineralized Freeze-dried Bone Allograft Block Fixed by Titanium Screw in Maxillary Esthetic Zone. J Contemp Dent Pract 2020;21(11):1205–1209.

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Somerman, Martha J. "Guest Editorial: Is There a Role for DFDBA in Periodontal Regenerative Therapy?" Journal of Periodontology 67, no. 9 (September 1996): 946–48. http://dx.doi.org/10.1902/jop.1996.67.9.946.

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Quoc, Johann Bui, Aurélie Vang, and Laurence Evrard. "Peri-Implant Bone Loss at Implants Placed in Preserved Alveolar Bone Versus Implants Placed in Native Bone: A Retrospective Radiographic Study." Open Dentistry Journal 12, no. 1 (July 31, 2018): 529–45. http://dx.doi.org/10.2174/1874210601812010529.

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Objectives: The aim of our study was to compare peri-implant bone loss at implants placed in alveolar sockets filled with a particulate allogenous bone graft (DFDBA 300-500 µm) and platelet concentrates versus at implants placed in the native bone. Materials and Methods: A retrospective clinical study was performed. A total of 84 patients were included with 247 implants for the restoration of mono and pluri-radicular teeth: 169 implants in native bone and 78 in socket-grafted bone. The peri-implant bone loss was measured by 2 independent operators at 6 and 12 months. Results: The overall mesial and distal peri-implant bone losses were 0.9 ± 0.7 mm and 0.9 ± 0.8 mm at 6 months, respectively, and 1 ± 0.65 mm and 1.2 ± 0.9 mm at 12 months, respectively. In the tested group, the bone loss was 0.8 ± 0.8 mm at 6 months and 1.2 ± 0.9 mm at 12 months. In the control group, the bone loss was 1.0 ± 0.7 mm at 6 months and 0.95 ± 0.6 mm at 12 months. There were no statistically significant differences in bone loss between the two groups. Taking both groups together, there were no statistically significant difference in bone loss between patients with or without histories of periodontitis, but there was a statistically significant difference in bone loss between the mandible and maxilla as well as between unitary and total edentations and between partially and total edentulous patients. Conclusion: At 6 and 12 months, the peri-implant bone loss in sockets preserved with DFDBA and platelet concentrates was similar to the peri-implant bone loss in native bone.

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Esquivel-Chirino, César, Vanessa Vargas-Romero, Gerardo Rodríguez-Torres, Verónica Villatoro-Ugalde, María Guadalupe Rivas-Fonseca, Delina G. Montes-Sánchez, Daniela Carmona Ruiz, Yolanda Valero Princet, and Christian Márquez-Correa. "Alveolar Ridge Preservation Using Autogenous Dentin Graft versus Demineralized Freeze-dried Bone Allograft (DFDBA): A Case Report." European Journal of Dental and Oral Health 2, no. 2 (April 26, 2021): 18–22. http://dx.doi.org/10.24018/ejdent.2021.2.2.45.

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Tooth extraction is a surgical procedure that is performed due to pulp and periapical pathology, periodontal disease, or teeth that are not deemed to be prosthetically or endodontically restorable. Following tooth extraction, bone resorption and vertical or horizontal defects occur. Traditionally, ridge preservation warrants the use of different agents such as autografts, allografts, xenografts, and mineral or ceramic materials. Autogenous dentin grafts are alternative to ridge preservation with osteoconductive, osteoinductive, and non-immunogenic properties to generate bone formation. The aim of the case report was to evaluate and compare clinical and histological outcomes using an autogenous dentin graft versus an allogeneic bone graft (DFDBA) as an alternative for ridge preservation.

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Rosetti, Elizabeth Pimentel, Rosemary Adriana Chiérici Marcantonio, Joni Augusto Cirelli, Elizangela Partata Zuza, and Elcio Marcantonio Jr. "Treatment of gingival recession with collagen membrane and DFDBA: a histometric study in dogs." Brazilian Oral Research 23, no. 3 (September 2009): 307–12. http://dx.doi.org/10.1590/s1806-83242009000300014.

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Oktiani, Beta Widya, Sri Pramestri Lastianny, and Ahmad Syaify. "Differences in effectiveness of membrane fixation using periosteal vertical mattress and simple sling suture techniques in infrabony pocket treatment." Majalah Kedokteran Gigi Indonesia 5, no. 2 (August 31, 2019): 75. http://dx.doi.org/10.22146/majkedgiind.37425.

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Guide tissue regeneration (GTR) is the treatment of infrabony pockets for soft and hard tissue regeneration. Membrane is used as a barrier and prevents apical migration of the cells in epithelial tissues. Membrane fixation is one of the procedures in GTR treatment because resorbed membrane is less stable. Simple sling suture technique for membrane fixation has 1 anchorage, located in coronal flap, while periosteal vertical mattress suture technique has 2 anchorages in periosteum, making it more stable. This study aimed to study the differences in the effectiveness of membrane fixation using periosteal vertical mattress suture and simple sling suture techniques in terms of probing depth, relative attachment loss, and alveolar bone height in the treatment of infrabony pockets. The samples were divided into 2 groups. The first group was open flap debridement (OFD) with demineralized freeze dried bone allograft (DFDBA) application and membrane fixation with simple sling suture, while the second group was OFD with DFDBA application and membrane fixation with periosteal vertical mattress suture, observed on day 0, 30th day, and 90th day. The results of the study showed significant differences in the probing depth and relative attachment loss (except from the 30th day to the 90th day), and there were no significant differences in the alveolar bone height from the baseline to the 90th day, between the group of membrane fixation using simple sling suture and that of periosteal vertical mattress suture techniques on flap surgery. This study concluded that membrane fixation in the treatment of infrabony pocket with periosteal vertical mattress suture technique is more effective in reducing the probing depth and relative attachment loss, but there is no difference in increasing the alveolar bone height when compared to simple sling suture technique.

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Pramod, VT. "Bone Grafts in Periodontics-A Review." CODS Journal of Dentistry 7, no. 2 (2015): 64–70. http://dx.doi.org/10.5005/cods-7-2-64.

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Abstract The ultimate goal of periodontal therapy should not be limited to the establishment and maintenance of periodontal health. The potential for regeneration of the hard and soft periodontal tissues lost to disease should be considered. Of all the bone grafting materials being developed, the demineralized freeze dried bone allograft (DFDBA) has been used as a substitute for bone graft for more than four decades. The basis for the use of any bone grafting material is to induce bone formation. In this article various bone grafts and biomaterials used are reviewed. How to cite this article Tatuskar P, Prakash S. Bone Grafts in Periodontics -A Review. CODS J Dent 2015;7: 64-70.

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Zenobio, Elton Golçalves, and Jamil Awad Shibli. "Treatment of Endodontic Perforations Using Guided Tissue Regeneration and Freeze-Dried Bone Allograft: Two Case Reports with 2-4 Year Post-Surgical Evaluations." Journal of Contemporary Dental Practice 5, no. 3 (2004): 131–41. http://dx.doi.org/10.5005/jcdp-5-3-131.

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Abstract Clinicians often have difficulty with the diagnosis and treatment of root perforation. This paper reports two patients with root perforation treated with periodontal surgery associated with guided tissue regeneration (GTR) and demineralized freeze-dried bone allograft (DFDBA). This combined treatment resulted in minimal probing depths, minimal attachment loss, and radiographic evidence of bone gain after follow-up evaluations that ranged from 2 to 4 years. These case reports show a correct diagnosis and removal of etiologic factors can restore both periodontal and endodontic health. Citation Zenobio EG, Shibli JA. Treatment of Endodontic Perforations Using Guided Tissue Regeneration and Freeze-Dried Bone Allograft: Two Case Reports with 2-4 Year Post-Surgical Evaluations. J Contemp Dent Pract 2004 August;(5)3:131-141.

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Baniasadi, Behrang, and Laurence Evrard. "Alveolar Ridge Preservation After Tooth Extraction with DFDBA and Platelet Concentrates: A Radiographic Retrospective Study." Open Dentistry Journal 11, no. 1 (February 14, 2017): 99–108. http://dx.doi.org/10.2174/1874210601711010099.

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Objectives: The purpose of this study was to evaluate vertical alveolar bone loss 3 months after tooth extraction when a technique of ridge preservation was applied using a particulate demineralized freeze-dried bone allograft 300 - 500 µm associated with platelet concentrates (platelet-rich-fibrin) in the form of gel and membranes. Material and Methods: A retrospective radiological clinical study was conducted on 56 patients for whom 95 extractions had been performed immediately followed by alveolar filling. Among the patients, 17 were smokers and 16 were provided with an immediate removable temporary prosthesis after extractions. Vertical bone loss was measured radiologically by panoramic X-ray before extractions and by a computed tomography scan 3 months after, at the level of mid-buccal bone wall, by two independent observers. For statistical analysis, Student’s t-test was performed to compare the mean bone loss between mono- and pluri-radicular teeth and to compare the mean bone loss between tobacco users versus non users and finally to compare the mean bone loss between individuals that had provisional removable prosthesis and those that had not. Results: Three months after tooth extraction, the mean of vertical loss of the mid-buccal bone wall was 0.72 (SD 0.71) mm (5.53% SD 5.19). No significant difference between bone loss at mono-radicular and pluri-radicular teeth (P = 0.982) was observed. There was no significant correlation between tobacco habits and bone loss (P = 0.2), nor between provisional removable prosthesis and bone loss (P = 0.786). Conclusion: These results indicate a good potential for the technique using Demineralized Freeze-Dried Bone Allograft 300 - 500 µm and platelet concentrates in alveolar bone preservation.

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Andreana, Sebastiano, Roberto Cornelini, Laura E. Edsberg, and Joseph R. Natiella. "Maxillary Sinus Elevation for Implant Placement Using Calcium Sulfate With and Without DFDBA: Six Cases." Implant Dentistry 13, no. 3 (September 2004): 270–77. http://dx.doi.org/10.1097/01.id.0000136914.82891.20.

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Agarwal, Ashish, R. G. Shiva Manjunath, Priyamwada Sethi, and G. Shiva Shankar. "Platelet-rich fibrin in combination with decalcified freeze-dried bone allograft for the management of mandibular degree II furcation defect: A randomised controlled clinical trial." Singapore Dental Journal 39, no. 01 (December 2019): 33–40. http://dx.doi.org/10.1142/s2214607519500032.

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Background: Treatment of furcation involvement of molars with periodontal disease remains challenging and unpredictable. Platelet-rich fibrin (PRF) has received the attention of researchers due to its pleiotropic properties essential for periodontal wound healing. The osteoinductive property of demineralized freeze-dried bone allograft (DFDBA) has been successfully used in periodontal regeneration. Aim: The present study aimed to explore the effectiveness of PRF alone and with DFDBA in the treatment of mandibular degree II furcation defects in subjects with chronic periodontitis. Material and Methods: Patients treated were from the Department of Periodontology and Implantology, Institute of Dental Sciences, Bareilly. A total of 60 mandibular molars were treated with either open flap debridement (OFD) alone, [Formula: see text] combination or [Formula: see text] combination. The soft and hard tissue parameters such as vertical probing depth (VPD), vertical clinical attachment level (VCAL), gingival marginal level (GML), horizontal probing depth (HPD), vertical bone fill (VBF), horizontal bone fill (HBF) and furcation width (FW) were determined at baseline and 9 months postoperatively. A paired [Formula: see text]-test was conducted to assess the statistical significance between time period within each group for clinical and radiographic parameters. ANOVA and post-hoc Tukey’s tests were also conducted for intergroup comparison of soft and hard tissue parameters. Statistical significance was set at [Formula: see text]. Results and Discussion: After 9 months, all treatment groups showed significant ([Formula: see text]) improvement in soft and hard tissue parameters, except GML in all the three groups and HBF and FW in the OFD group as compared to baseline. The mean VBF change was highest in the [Formula: see text] group ([Formula: see text]) mm, followed by that in the [Formula: see text] and OFD groups ([Formula: see text] and [Formula: see text][Formula: see text]mm, respectively). Conclusions: It was shown that both [Formula: see text] and [Formula: see text] combinations were significantly advantageous for the management of mandibular degree II furcation defects. However, the [Formula: see text] combination has significantly greater benefits than [Formula: see text] combination in terms of VBF.

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Alizadeh Tabari, Zahra, Hamed Homayouni, Tahere Pourseyediyan, Armita Arvin, Derrick Eiland, and Nima Moradi Majd. "Treatment of a Developmental Groove and Supernumerary Root Using Guided Tissue Regeneration Technique." Case Reports in Dentistry 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/2738569.

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Introduction. The radicular groove is a developmental groove which is usually found on the palatal or lateral aspects of the maxillary incisor teeth. The present case is a maxillary lateral incisor with a small second root and a deep radicular groove. The developmental groove caused a combined periodontal-endodontic lesion. Methods. Case was managed using a combined treatment procedure involving nonsurgical root canal therapy and surgical periodontal treatment. After completion of root canal treatment, guided tissue regeneration (GTR) was carried out using decalcified freeze dried bone allograft (DFDBA) and a bioabsorbable collagenous membrane. Tooth also was splinted for two months. Results. After 12 months the tooth was asymptomatic. The periapical radiolucency disappeared and probing depth did not exceed 3 mm. Conclusion. Combined treatment procedure involving nonsurgical root canal therapy and surgical periodontal regenerative treatment can be a predictable technique in treating combined endodontic-periodontal lesions caused by radicular groove.

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Chang, R., C. Su, and C. Cheng. "A stereomorphological study of bone regeneration following hydroxyapatite of DFDBA implantation using SEM with EDTA-KOH method." International Journal of Oral and Maxillofacial Surgery 28 (January 1999): 21. http://dx.doi.org/10.1016/s0901-5027(99)80729-2.

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Miron, Richard J., Anton Sculean, Yang Shuang, Dieter D. Bosshardt, Reinhard Gruber, Daniel Buser, Fatiha Chandad, and Yufeng Zhang. "Osteoinductive potential of a novel biphasic calcium phosphate bone graft in comparison with autographs, xenografts, and DFDBA." Clinical Oral Implants Research 27, no. 6 (July 30, 2015): 668–75. http://dx.doi.org/10.1111/clr.12647.

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Anton, Anton, Poerwati S. Rahajoe, and Bambang Dwirahardjo. "Sandwich Bone Augmentation (SBA) in immediate implant placement post dentoalveolar trauma: a case report." Journal of Dentomaxillofacial Science 2, no. 3 (December 1, 2017): 197. http://dx.doi.org/10.15562/jdmfs.v2i3.643.

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Objective: Reporting the application of SBA procedure with titanium mesh as an alternative solution for immediate implant placement in socket with dentoalveolar trauma-induced buccal bone defect.Methods: An 18-year-old female patient visited our department, with a history dentoalveolar trauma and a loss of tooth 21. Clinical examination during the implant placement procedure exposed a socket with buccal bone defect. SBA with autogenous chin bone graft combined with DFDBA allograft and stabilized with titanium mesh (Ti-Mesh) for buccal defect on which flap reposition was done with tension free primary closure.Results: Ti-Mesh was removed after 3 months which no sign of inflamation appeared, implant was in a stable condition and new bone formation was observed. Subsequently, healing abutment was placed. A one-year observation suggested a good clinical retention with no luxation observed, along with decent functional and esthetic results. CBCT evaluation showed buccal bone thickness preserved.Conclusion: Sandwich bone augmentation with stabilized titanium mesh provides a satisfying result in treating horizontal buccal bone defect.

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Wijayanto, Hendry Dwi, and Kwartarini Murdiastuti. "Perawatan Bonegraft dengan Penambahan Platelet-Rich Plasma dan Kolagen pada Kerusakan Infraboni." Majalah Kedokteran Gigi Klinik 1, no. 1 (June 29, 2016): 9. http://dx.doi.org/10.22146/mkgk.11912.

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Perawatan kerusakan jaringan periodontal mempunyai tujuan utama mendapatkan jaringan regeneratif dan proses yang berlangsung membentuk struktur jaringan yang fungsional melalui proses pertumbuhan serta diferensiasi sel sel baru. Bonegraft adalah perawatan untuk kasus kerusakan tulang. Platelet-rich plasma yang merupakan platelet autologus konsentrasi tinggi tersuspensi dalam plasma setelah disentrifugasi. Dalam PRP banyak terdapat komponen yang berperan dalam proses penyembuhan regeneratif, growth faktor, agen kemotaktik dan agen vasoaktif. Kombinasi dengan penambahan kolagen merupakan altematif yang aman dan efektif, selain menstimulasi pelepasan growth faktor pada daerah target, juga memperkuat signal agar degranulasi platelet dapat ditingkatkan. Pada kasus ini, wanita berusia 24 tahun mengeluhkan keadaan giginya goyah sejak 3 bulan yang lalu karena traumatik, tidak ada rasa nyeri. Setelah dilakukan rontgen periapikal digital terlihat terjadinya kerusakan tulang infraboni. Penanganan untuk kasus ini dirancang dengan bedah flap, bonegraft Demineralized Freeze-Dried Bovine Bone Allograft (DFDBA), aplikasi platelet-rich plasma, serta penambahan kolagen. Kombinasi bonegraft dengan aplikasi PRP dan penambahan kolagen untuk menunjang perawatan periodontal memberikan hasil yang memuaskan secara penampakan klinis dan penampakan radiografis. ABSTRACT: Bonegraft Treatment with Addition of Platelet - Rich Plasma and Collagen in Infrabony Defect. The treatment of periodontal tissue damage has the main goal to get regenerative tissues and processes that take place to form a functional network structure through the process of cell growth and differentiation of new cells. Bonegraft is a treatment for cases of bone damage. Platelet-rich plasma is autologous platelets suspended in plasma high concentrations after centrifugation. In PRP, there are many components that play a role as a regenerative agent of healing process, growth factors, chemotactic agents and vasoactive agents. Its combination with the addition of collagen is a safe and effective alternative; in addition to stimulating the release of growth factors in the target area, it also strengthens the signal to improve platelet degranulation. In this case, a 24-year-old woman complained of unsteady state of her teeth since the last 3 months due to trauma; there was no pain. A digital periapical X-ray exposed infrabony defect. The treatment for this case was designed to use a surgical flap, bonegraft Demineralized Freeze-Dried Bovine Bone Allograft (DFDBA), application of platelet-rich plasma, as well as the addition of collagen. Bonegraft combination with PRP application and the addition of collagen to support periodontal treatment have given satisfactory results in the clinical and radiographic appearance.

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Brugnami, Federico, Peter R. Then, Hidetada Moroi, and Cataldo W. Leone. "Histologic Evaluation of Human Extraction Sockets Treated With Demineralized Freeze-Dried Bone Allograft (DFDBA) and Cell Occlusive Membrane." Journal of Periodontology 67, no. 8 (August 1996): 821–25. http://dx.doi.org/10.1902/jop.1996.67.8.821.

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34

Lee, Po-Hui, Tu-Lai Yew, Yu-Lin Lai, Shyh-Yuan Lee, and Hen-Li Chen. "Parathyroid hormone gene-activated matrix with DFDBA/collagen composite matrix enhances bone regeneration in rat calvarial bone defects." Journal of the Chinese Medical Association 81, no. 8 (August 2018): 699–707. http://dx.doi.org/10.1016/j.jcma.2017.12.004.

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35

Patil, RatnadeepC, S. Kanchan, and K. Ramanathan. "Immediate implant placement in conjunction with a DFDBA graft and resorbable membrane: A 1-10 year retrospective clinical study." Journal of Indian Prosthodontic Society 5, no. 4 (2005): 203. http://dx.doi.org/10.4103/0972-4052.21637.

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Vahabi, Surena, Maryam Torshabi, and Mohammad Mohammadi. "Osteoinductive Activity of DFDBA Materials versus Growth Factors on Gene Expression of MG-63 Cells: An In Vitro Study." Journal of Long-Term Effects of Medical Implants 26, no. 2 (2016): 133–42. http://dx.doi.org/10.1615/jlongtermeffmedimplants.2016014611.

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Zhou, Shuai, Chengjia Sun, Shaohui Huang, Ximing Wu, Yan Zhao, Chunling Pan, Hongyan Wang, Junchao Liu, Qian Li, and Yurong Kou. "Efficacy of Adjunctive Bioactive Materials in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis." BioMed Research International 2018 (May 27, 2018): 1–15. http://dx.doi.org/10.1155/2018/8670832.

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Objectives. Lots of bioactive materials have been additionally applied for the treatment of periodontal intrabony defect. However, there is dearth of studies to systematically evaluate the supplementary role of them in periodontal regeneration. The goal of this meta-analysis is to evaluate the adjunctive effects of bioactive materials such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), enamel matrix derivative (EMD), and amnion membrane (AM) on the outcomes of bone grafting treatment for periodontal intrabony defects. Methods. Articles published before December 2017 were searched electronically in three databases (PubMed, Embase, and Cochrane Central), with no date or language limits. Randomized controlled trials (RCTs) on the assessment of effectiveness of the four biomaterials in conjunction with demineralized freeze-dried bone allografts (DFDBA) in the treatment of periodontal intrabony defects were enrolled in this meta-analysis. Data were analyzed with STATA 12. Results. Nine studies were included. PRF and PRP significantly improved pocket depth (PD) reduction and clinical attachment loss (CAL) gain. Only PRF exhibited a positive result in recession reduction (RecRed). Only PRP showed a statistically significant increase in bone fill. AM merely gained more CAL. EMD did not improve any clinical outcome. Conclusion. Our data suggest that PRF/PRP could be taken as a preferred adjunct to facilitate periodontal regeneration of intrabony defects.

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Kothiwale, Shaila V., P. Anuroopa, and A. L. Gajiwala. "A clinical and radiological evaluation of DFDBA with amniotic membrane versus bovine derived xenograft with amniotic membrane in human periodontal grade II furcation defects." Cell and Tissue Banking 10, no. 4 (March 10, 2009): 317–26. http://dx.doi.org/10.1007/s10561-009-9126-3.

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aghayan, shabnam, Ahmad Asghari, Pejman Mortazavi, and haniyeh haeri araghi. "Histomorphometric Comparison of 2 types of FDBA and DFDBA bone powders manufactured by Faravardehaye Peyvandi Iran Company in treatment of defects in rabbit calvaria bone." journal of research in dental sciences 17, no. 1 (March 1, 2020): 1–10. http://dx.doi.org/10.29252/jrds.17.1.1.

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aghayan, shabnam, Ahmad Asghari, Pejman Mortazavi, and shahrzad ghashghai. "Histomorphometric Comparison of 2 types of FDBA and DFDBA bone powders manufactured by Hamanand Saz Baft Kish Company in treatment of defects in rabbit calvaria bone." journal of research in dental sciences 16, no. 1 (April 1, 2019): 1–12. http://dx.doi.org/10.29252/jrds.16.1.1.

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Kukreja, BhavnaJha, Vidya Dodwad, Pankaj Kukreja, Sakshi Ahuja, and Praful Mehra. "A comparative evaluation of platelet-rich plasma in combination with demineralized freeze-dried bone allograft and DFDBA alone in the treatment of periodontal intrabony defects: A clinicoradiographic study." Journal of Indian Society of Periodontology 18, no. 5 (2014): 618. http://dx.doi.org/10.4103/0972-124x.142457.

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Panwar, Mohinder, Dhruv Dubey, and Manab Kosala. "Innovative Periodontal Surgery by Monocortical Corticotomy in Management of Bimaxillary Protrusion Cases: A Clinical Study." International Journal of Experimental Dental Science 6, no. 2 (2017): 55–60. http://dx.doi.org/10.5005/jp-journals-10029-1156.

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ABSTRACT Periodontal accelerated osteogenic orthodontics (PAOO) is a procedure applying the clinical science of alveolar corticotomy, particulate bone grafting, and the application of orthodontic forces, for accentuated tooth movement. This is theoretically based on the bone healing pattern known as the regional acceleratory phenomenon (RAP). A series of 12 cases, including 8 females and 4 males, were included in the study. The cases were referred from the Department of Orthodontia to the Department of Periodontology, ADC (R&R), having bimaxillary protrusion with an increased overjet. After initial orthodontic alignment, buccal corticotomy procedure was planned. A full-thickness mucoperiosteal flap was reflected from maxillary canine to canine beyond the root apices. Vertical corticotomy cuts were given in the alveolar bone with piezo blades 2 mm apical to the crestal bone in the inter-radicular space midway between the root prominences and were joined by the horizontal cuts apically. Demineralized freeze-dried bone allograft (DFDBA) was placed in the surgical area. The flaps were sutured and pack was placed. Orthodontic retraction was started 2 weeks after the corticotomy procedure. Using this procedure, the treatment objectives were met in just half to one-third of the reported conventional treatment time and the large overjet was reduced to normal. Pre- and posttreatment clinical parameters were recorded, statistically analyzed, and corroborated with similar orthodontic treatment procedures without the use of the corticotomy technique. The present periodontal (PDL) intervention results in quick and stable results for the correction of bimaxillary protrusion cases. It enhances the esthetics and posttreatment orthodontic stability. How to cite this article Panwar M, Dubey D, Kosala M. Innovative Periodontal Surgery by Monocortical Corticotomy in Management of Bimaxillary Protrusion Cases: A Clinical Study. Int J Experiment Dent Sci 2017;6(2):55-60.

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Evrard, Laurence, Johann Bui Quoc, Christian Oliver Ferrer, Adnane Wardani, and Ilyes Larabi. "Comparison in peri‐implant marginal bone loss at implants placed in pristine bone versus at those placed in sinus lift or preserved Alveolar Bone with DFDBA and A‐PRF: A Retrospective Radiographic Study." Clinical Oral Implants Research 30, S19 (September 2019): 415. http://dx.doi.org/10.1111/clr.371_13509.

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Yoneda, Atsushi, Tsuyoshi Fukuhara, and Shoji Hara. "Selective monofluorination of diols using DFMBA." Chemical Communications, no. 28 (2005): 3589. http://dx.doi.org/10.1039/b502471d.

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Domanina, A. M., M. V. Chernikov, I. P. Remezova, E. F. Stepanova, A. M. Shevchenko, and A. V. Morozov. "Preparation of 2-phenyl-9-diethylaminoethylimidazo[1,2-α]benzimidazole dinitrate tablets and development of quality control methods." Drug development & registration 10, no. 2 (May 29, 2021): 62–67. http://dx.doi.org/10.33380/2305-2066-2021-10-2-62-67.

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Introduction. Currently, for the treatment of gastric ulcer, drugs with a combined effect are used. To eliminate possible side effects of the drugs used, the search for new molecules to create more effective and safe histamine H2 receptors continues. As a possible solution to these problems, we investigated the substance dinitrate of 2-phenyl-9-diethylaminoethylimidazo[1,2-α]benzimidazole (DFDB).Aim. The aim of this study was to obtain 2-phenyl-9-diethylaminoethylimidazo[1,2-α]benzimidazole dinitrate tablets and develop methods for quality control.Materials and methods. The object of study was tablets based on the substance DF DB. The physicochemical and technological properties of the tablet dosage form were studied. Pharmaco-technological and physico-chemical indicators were determined according to the methods of the State Pharmacopoeia of the XIV edition. Identification and quantitative determination of DFDB in tablets was performed by HPLC.Results and discussion. Based on the physico-chemical properties and determination of the main technological indicators of DFDB, an optimal tableting technology has been developed. The optimal composition of tablets has been developed. Identification of tablets is proposed to be carried out using HPLC in comparison with the standard sample of DFDB. Related impurities, according to the data obtained, do not exceed 0.1 %. We found that the tablets do not have an antimicrobial effect. The analyzed tablets correspond to category 3A. The content of DFDB should be from 95 to 105 % of the declared amount in one tablet. During the analysis, we conducted biopharmaceutical and technological studies of the finished dosage form during storage under the conditions of long-term stability testing in polymer cans with screw-on lids. It is shown that the selected composition of excipients and the production technology ensure the stability of the finished dosage form for two years of storage under the observed conditions. To select the tableting technology, the main technological properties of the DFDB substance are analyzed. The choice of excipients and the composition of the film coating was carried out.Conclusion. The technology is developed and standardization of tablets based on the substance DFDB is proposed.

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Marsh, MAJ Tennille. "Civilian Sentencing Principles in Summary Military Discipline Proceedings." Journal of International Peacekeeping 20, no. 3-4 (August 17, 2016): 230–49. http://dx.doi.org/10.1163/18754112-02003006.

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The Australian Defence Force (adf) has had a number of inquiries or reviews into its military justice system in the past two decades. The recommendations of those inquiries have led to an increasing ‘civilianisation’ of the military discipline system. Nowhere is this more apparent than in the specific requirement of section 70 of the Defence Force Discipline Act (dfda) which requires sentencing authorities to explicitly consider ‘civilian’ sentencing principles. Given that the vast majority of adf personnel plead guilty during summary hearings, it is the sentencing process that is the most critical exercise of legal principles in the summary jurisdiction. The requirement to explicitly consider civilian sentencing principles, where such principles are not defined in the dfda, and are hotly contested amongst highly educated and experienced civilian lawyers, is impractical, inappropriate and does not serve what should be the fundamental purpose of the dfda: the maintenance of service discipline. This paper will discuss the difficulties of the current ‘civilianisation’ of the sentencing process and will propose potential guidelines for legislative reform of section 70 of the dfda, particularly in relation to summary authority hearings.

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Furuya, Tsukasa, Tsuyoshi Fukuhara, and Shoji Hara. "Synthesis of gem-difluorides from aldehydes using DFMBA." Journal of Fluorine Chemistry 126, no. 5 (May 2005): 721–25. http://dx.doi.org/10.1016/j.jfluchem.2005.02.004.

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Kim, Y., Y. H. Kown, J. B. Park, J. H. Chung, H. N. Lim, S. S. Jue, M. I. Cho, and Y. Herr. "Porous Titanium Membranes Combined with Various Graft Materials Induce Exophytic Bone Formation in Rabbit Calvaria." Key Engineering Materials 309-311 (May 2006): 427–32. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.427.

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Abstract:

The purpose of this study was to examine if the application of custom-made porous titanium membranes combined with bone graft materials promotes exophytic bone formation in rabbit calvaria. For this purpose, round decorticated calvaria sites were created using a round carbide bur. In the control group, rectangular parallelepiped-shaped porous titanium membranes (RPTMs) were placed on the decorticated sites and fixed with metal pins. In the experimental groups, RPTMs were filled with one of the following bone graft materials prior to fixing with metal pins: bovine bone mineral (BBM), demineralized freeze-dried human cortical bone (DFDB) or freeze-dried human cancellous bone (FDB). Animals were sacrificed at 8 and 12 weeks after surgery, and new bone formation was assessed by histomorphometric as well as statistical analysis. The results indicate that at 8 and 12 weeks, all the experimental groups demonstrated exophytic bone formation. At 12 weeks, DFDB group revealed the most new bone formation (p<0.05) and resorption of grafted materials (p<0.05). On the basis of these findings, we conclude that RPTMs may be used as an augmentation membrane for guided bone regeneration and DFDB as an effective bone-inducing graft material.

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Yen, Barbara T. H., and Yu-Chiun Chiou. "Dynamic fuzzy data envelopment analysis models: case of bus transport performance assessment." RAIRO - Operations Research 53, no. 3 (July 2019): 991–1005. http://dx.doi.org/10.1051/ro/2017064.

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Abstract:

In the transport field, two characteristics–inter-temporal dependency and fuzziness–need to be considered when assessing transport performance. First, input and output levels are inter-temporal dependent due to heavy capital investment and because quasi-fixed input can influence output levels over multiple periods. Second, conventional Data Envelopment Analysis (DEA) models are, in nature, formulated with quantitative variables. However, qualitative measurements that are characterized with “vagueness” or “fuzziness” are as important as quantitative variables for multi-period transport performance assessment. To rectify these problems, the present study extends previous research by proposing a Dynamic Fuzzy Data Envelopment Analysis (DFDEA) method for assessing the comparative efficiency where inter-temporal dependence exists in operating production processes with some “fuzzy” variables. An case study was conducted to evaluate the performance of city bus transport companies in Taipei, Taiwan. Results showed the superiority of the proposed DFDEA model by comparing the results with static models.

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Uygun, Korkut, Howard W. T. Matthew, and Yinlun Huang. "DFBA-LQR: An Optimal Control Approach to Flux Balance Analysis." Industrial & Engineering Chemistry Research 45, no. 25 (December 2006): 8554–64. http://dx.doi.org/10.1021/ie060218f.

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Journal articles on the topic 'DFDBA'

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