Relevant bibliographies by topics / DGKκ

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'DGKκ'

Author: Grafiati
Published: 2 November 2024
Last updated: 31 July 2025

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Journal articles on the topic "DGKκ"

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Gravina, Teresa, Chiara Maria Teresa Boggio, Elisa Gorla, et al. "Role of Diacylglycerol Kinases in Acute Myeloid Leukemia." Biomedicines 11, no. 7 (2023): 1877. http://dx.doi.org/10.3390/biomedicines11071877.

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Diacylglycerol kinases (DGKs) play dual roles in cell transformation and immunosurveillance. According to cancer expression databases, acute myeloid leukemia (AML) exhibits significant overexpression of multiple DGK isoforms, including DGKA, DGKD and DGKG, without a precise correlation with specific AML subtypes. In the TGCA database, high DGKA expression negatively correlates with survival, while high DGKG expression is associated with a more favorable prognosis. DGKA and DGKG also feature different patterns of co-expressed genes. Conversely, the BeatAML and TARGET databases show that high DG
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Tabet, Ricardos, Enora Moutin, Jérôme A. J. Becker, et al. "Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons." Proceedings of the National Academy of Sciences 113, no. 26 (2016): E3619—E3628. http://dx.doi.org/10.1073/pnas.1522631113.

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Fragile X syndrome (FXS) is caused by the absence of the Fragile X Mental Retardation Protein (FMRP) in neurons. In the mouse, the lack of FMRP is associated with an excessive translation of hundreds of neuronal proteins, notably including postsynaptic proteins. This local protein synthesis deregulation is proposed to underlie the observed defects of glutamatergic synapse maturation and function and to affect preferentially the hundreds of mRNA species that were reported to bind to FMRP. How FMRP impacts synaptic protein translation and which mRNAs are most important for the pathology remain u
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YAMADA, Keiko, Fumio SAKANE, Norio MATSUSHIMA та Hideo KANOH. "EF-hand motifs of α, β and γ isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes". Biochemical Journal 321, № 1 (1997): 59–64. http://dx.doi.org/10.1042/bj3210059.

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The three diacylglycerol kinase isoenzymes (DGKα, DGKβ and DGKγ) cloned so far contain in common a tandem repeat of EF-hand motifs. However, the Ca2+ dependences of the DGK activities are known to be variable between isoenzymes, and the Ca2+-binding activities of these motifs have not been tested except for those present in DGKα. We therefore attempted to define the intrinsic properties of EF-hands occurring in the DGK isoenzymes. For this purpose we bacterially expressed and purified the EF-hand motifs (termed DKE forms) of the three DGKs. Equilibrium dialysis with the purified DKE forms show
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Ren, Xiaodi, Yvonne Lo, Michelle Pusey та ін. "Abstract 3789: INCB177054: A novel, potent, orally bioavailable DGKα/ζ dual inhibitor enhances T-cell function and demonstrates potent antitumor activity". Cancer Research 85, № 8_Supplement_1 (2025): 3789. https://doi.org/10.1158/1538-7445.am2025-3789.

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Abstract Host immune responses play an important role in fighting cancers; therefore, improving these responses against tumor cells is of high interest in cancer therapy. Diacylglycerol (DAG) is a key second messenger that transduces T-cell receptor (TCR) activation signal to downstream effectors through DAG-binding proteins. DAG kinase (DGK) isoforms α and ζ are the major enzymes that modulate DAG levels in T cells and serve as intracellular checkpoints to attenuate TCR activation. Here, we describe INCB177054, a novel, potent, selective, and orally bioavailable small molecule DGKα/ζ dual inh
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Baldanzi, Gianluca, та Mario Malerba. "DGKα in Neutrophil Biology and Its Implications for Respiratory Diseases". International Journal of Molecular Sciences 20, № 22 (2019): 5673. http://dx.doi.org/10.3390/ijms20225673.

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Diacylglycerol kinases (DGKs) play a key role in phosphoinositide signaling by removing diacylglycerol and generating phosphatidic acid. Besides the well-documented role of DGKα and DGKζ as negative regulators of lymphocyte responses, a robust body of literature points to those enzymes, and specifically DGKα, as crucial regulators of leukocyte function. Upon neutrophil stimulation, DGKα activation is necessary for migration and a productive response. The role of DGKα in neutrophils is evidenced by its aberrant behavior in juvenile periodontitis patients, which express an inactive DGKα transcri
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Gharbi, Severine I., Esther Rincón, Antonia Avila-Flores та ін. "Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse". Molecular Biology of the Cell 22, № 22 (2011): 4406–14. http://dx.doi.org/10.1091/mbc.e11-03-0247.

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Diacylglycerol (DAG) generation at the T cell immunological synapse (IS) determines the correct activation of antigen-specific immune responses. DAG kinases (DGKs) α and ζ act as negative regulators of DAG-mediated signals by catalyzing DAG conversion to phosphatidic acid (PA). Nonetheless, the specific input of each enzyme and their spatial regulation during IS formation remain uncharacterized. Here we report recruitment of endogenous DGKα and DGKζ to the T cell receptor (TCR) complex following TCR/CD28 engagement. Specific DGK gene silencing shows that PA production at the activated complex
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Katagiri, Yuji, Tsukasa Ito, Sachiko Saino-Saito, et al. "Expression and localization of diacylglycerol kinase isozymes and enzymatic features in rat lung." American Journal of Physiology-Lung Cellular and Molecular Physiology 288, no. 6 (2005): L1171—L1178. http://dx.doi.org/10.1152/ajplung.00237.2004.

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Diacylglycerol kinase (DGK) catalyzes phosphorylation of diacylglycerol to generate phosphatidic acid, and both molecules are known to serve as second messengers as well as important intermediates for the synthesis of various lipids. In this study, we investigated the spatiotemporal expression patterns of DGK isozymes together with the developmental changes of the mRNA expression and enzymatic property in rat lung. Northern blot and RT-PCR analyses showed that mRNAs for DGKα, -ε, and -ζ were detected in the lung. By immunohistochemical examination, DGKα and -ζ were shown to be coexpressed in a
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Topham, Matthew K., та Stephen M. Prescott. "Diacylglycerol Kinase ζ Regulates Ras Activation by a Novel Mechanism". Journal of Cell Biology 152, № 6 (2001): 1135–44. http://dx.doi.org/10.1083/jcb.152.6.1135.

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Guanine nucleotide exchange factors (GEFs) activate Ras by facilitating its GTP binding. Ras guanyl nucleotide-releasing protein (GRP) was recently identified as a Ras GEF that has a diacylglycerol (DAG)-binding C1 domain. Its exchange factor activity is regulated by local availability of signaling DAG. DAG kinases (DGKs) metabolize DAG by converting it to phosphatidic acid. Because they can attenuate local accumulation of signaling DAG, DGKs may regulate RasGRP activity and, consequently, activation of Ras. DGKζ, but not other DGKs, completely eliminated Ras activation induced by RasGRP, and
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ROCHE, Marc A. de la, Janet L. SMITH, Maribel RICO та ін. "Dictyostelium discoideum has a single diacylglycerol kinase gene with similarity to mammalian θ isoforms". Biochemical Journal 368, № 3 (2002): 809–15. http://dx.doi.org/10.1042/bj20021027.

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Diacylglycerol kinases (DGKs) phosphorylate the neutral lipid diacylglycerol (DG) to produce phosphatidic acid (PA). In mammalian systems DGKs are a complex family of at least nine isoforms that are thought to participate in down-regulation of DG-based signalling pathways and perhaps activation of PA-stimulated signalling events. We report here that the simple protozoan amoeba Dictyostelium discoideum appears to contain a single gene encoding a DGK enzyme. This gene, dgkA, encodes a deduced protein that contains three C1-type cysteine-rich repeats, a DGK catalytic domain most closely related t
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DU, Xiangnan, Ying JIANG, Weijun QIAN, Xiaolan LU та James P. WALSH. "Fatty acids inhibit growth-factor-induced diacylglycerol kinase α activation in vascular smooth-muscle cells". Biochemical Journal 357, № 1 (2001): 275–82. http://dx.doi.org/10.1042/bj3570275.

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We have previously shown that unsaturated fatty acids amplify platelet-derived-growth-factor (PDGF)-induced protein kinase C (PKC) activation in vascular smooth-muscle cells (VSMCs). Diacylglycerol-induced PKC activation is normally terminated by diacylglycerol kinases (DGKs). We thus hypothesized that fatty acids act by inhibiting a DGK. Fractionation of VSMC extracts demonstrated that the DGK α isoform was the major DGK activity present. PDGF markedly increased the DGK activity of cultured cells. An inhibitor selective for the DGK α isoform,R59949[3-{2-[4-(bis-(4-fluorophenyl)methylene]piper
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Dissertations / Theses on the topic "DGKκ"

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Çakil, Oktay. "Regulation of the diacylglycerol kinase kappa (DGKk) by FMRP and its dysregulation in Fragile X Syndrome." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ031.

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Le syndrome de l'X fragile (FXS) est la principale cause familiale de déficience intellectuelle et d'autisme. Le FXS résulte de la perte d’expression de la protéine de liaison aux ARN, FMRP. L’équipe a précédemment découvert que l'ARNm de la diacylglycérol kinase kappa (DGKκ) est une cible principale de FMRP. DGKκ est une enzyme régulatrice de la signalisation lipidique dont la perte d’expression dans le FXS pourrait expliquer les phénotypes observés. Nous avons démontré que la réexpression de DGKκ dans le cerveau de souris Fmr1-KO à l'aide d’un vecteur viral adéno-associé corrige à long terme
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Yellenki, Vaibhav. "Role of Diacylglycerol kinase alpha (DGKA) as a therapeutic target in Glioblastoma (GB)." Doctoral thesis, Università del Piemonte Orientale, 2020. http://hdl.handle.net/11579/115034.

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Glioblastoma (GB) is the most common high-grade fatal brain tumor. The standard of care treatment is surgery, followed by radiotherapy and chemotherapy. Despite decades of research, the median life expectancy of patients is still between 12 to 15 months. The activation of multiple receptor tyrosine kinases (RTKs) and/or downstream tumour-intrinsic mutations provide oncogenic stimuli to GB progression and accounts for resistance to current therapies. Identifying a target that is capable of simultaneously disabling of multiple, parallel oncogenic signals can represent an effective therapy. Mou
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Velnati, Suresh. "Development of novel DGKα inhibitors for the treatment of XLP1 and metastatic tumours". Doctoral thesis, Università del Piemonte Orientale, 2020. http://hdl.handle.net/11579/115022.

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Heil, Alexandra [Verfasser], and Andreas [Gutachter] Reif. "Assoziation einer DGKH-Risikogenvariante mit phänotypischen Merkmalen bei bipolar-affektiv erkrankten Patienten / Alexandra Heil ; Gutachter: Andreas Reif." Würzburg : Universität Würzburg, 2016. http://d-nb.info/1117477266/34.

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Fagundes, Gabriela Xavier. "Imunolocalização de células positivas para a enzima diacilglicerol quinase α (DGKα) em polpas de ratos expostas à contaminação". Pontifícia Universidade Católica do Rio Grande do Sul, 2014. http://hdl.handle.net/10923/6678.

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Made available in DSpace on 2014-07-08T02:01:24Z (GMT). No. of bitstreams: 1 000459063-Texto+Completo-0.pdf: 1347092 bytes, checksum: 2e34761fdd59a6506f5f964b304ec24c (MD5) Previous issue date: 2014<br>Introduction: Dental pulp is composed of loose connective tissue, which reacts when facing a pathogenic agent, and the inflammation is the first response. DGKα is one of the key enzymes involved on inflammations cellular events. It participates on the neutrophils recruiting to the injury site and on the regulation of superoxide production. The aim of this study was to evaluate the localization
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Fagundes, Gabriela Xavier. "Imunolocaliza??o de c?lulas positivas para a enzima diacilglicerol quinase ? (DGK?) em polpas de ratos expostas ? contamina??o." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2014. http://tede2.pucrs.br/tede2/handle/tede/1257.

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Made available in DSpace on 2015-04-14T13:30:34Z (GMT). No. of bitstreams: 1 459063.pdf: 1347092 bytes, checksum: 2e34761fdd59a6506f5f964b304ec24c (MD5) Previous issue date: 2014-03-12<br>Introduction: Dental pulp is composed of loose connective tissue, which reacts when facing a pathogenic agent, and the inflammation is the first response. DGK? is one of the key enzymes involved on inflammations cellular events. It participates on the neutrophils recruiting to the injury site and on the regulation of superoxide production. The aim of this study was to evaluate the localization of the DGK?
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Kang, Kiho Paul. "Commandes robustes d'un actionneur synchrone." Grenoble INPG, 1996. http://www.theses.fr/1996INPG0097.

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Le travail présenté dans cette thèse est consacré à la commande robuste d'un axe synchrone. Cet axe est un système qui risque d'être fortement perturbé par le couple de charge et le bruit sur la sortie. Sur le plan théorique, des lois de commande robuste basées sur l'algorithme DGKF et sur l'approche µ, sont développées. Ces lois de commande permettent de contrôler l'axe indifféremment du comportement des deux perturbations seulement si ces dernières peuvent être définies par leurs bornes. Par ailleurs, pour obtenir le modèle nominal, une approche d'identification itérative en boucle fermée es
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Kovalenko, Andrii. "Therapeutic targeting of DGKA-mediated macropinocytosis in lymphangioleiomyomatosis." Thesis, 2020. https://hdl.handle.net/2144/41149.

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BACKGROUND: Lymphangioleiomyomatosis (LAM) is a rare disease characterized by cystic destruction of the lung. It occurs in 80% of people with Tuberous Sclerosis Complex disorder (TSC), a multisystem, autosomal dominant disorder caused by mutations in tumor suppressor genes TSC1 and TSC2. Spontaneous biallelic mutations in these genes can give rise to sporadic LAM. Mammalian target of rapamycin complex I (mTORC1), a master regulator of cellular anabolic metabolism is hyperactivated in LAM cells. Upregulation of protein synthesis and downregulation of autophagy creates a state of starvation stre
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Heil, Alexandra. "Assoziation einer DGKH-Risikogenvariante mit phänotypischen Merkmalen bei bipolar-affektiv erkrankten Patienten." Doctoral thesis, 2015. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-139051.

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Die Tatsache, dass sich DGKH-GAT in einer vorausgehenden Studie als ein krankheitsübergreifender Risiko-Haplotyp für verschiedene Stimmungserkrankungen herausstellte, legte für uns den Schluss nahe, dass dieser Einfluss auf psychiatrische Symptome haben könnte, die typischerweise mit Stimmungsschwankungen einhergehen. In Anlehnung an das Endophänotypenkonzept vermuteten wir, dass wir über die Symptomebene möglicherweise Parameter definieren könnten, die enger mit DGKH-GAT assoziiert sind als die bipolar-affektive Erkrankung selbst. Ziel dieser Doktorarbeit war es daher, den Einfluss von DGKH-G
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Dias, Sara Melo. "Characterization of a chromosome rearrangement associated with cardiopathy and autism." Master's thesis, 2017. http://hdl.handle.net/10362/27627.

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Chromosomal rearrangements have been associated with multiple congenital abnormalities, including malformative syndromes and global developmental delay. The aim of this study was identification of candidate genes for a complex phenotype characterized by cardiopathy and autism, identified in an individual with a chromosome translocation t(4;7)(q21.1;p21.2). Since classical and molecular cytogenetic analyses have low resolutions, large-insert whole-genome sequencing (liWGS) was applied for identification and mapping of structural chromosomal alterations. By this approach, the 4q21.1 breakpoint
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Books on the topic "DGKκ"

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Ontario., Ministry of Culture and Communications., Kenora Field Office. Turtles and tourists: Excavations at the Nestor Falls site (DgK1-3) 1989 and 1990. Ministry of Culture and Communication, 1992.

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Germany) Symposium der DGK (14th 2001 Hamburg. Innovative Analytik in der Kosmetik: Proceedings : 14. Symposium der DGK Hamburg, 2001, Deutsche Gesellschaft für Wissenschaftliche und Angewandte Kosmetik e.V. Verlag für chemische Industrie, 2001.

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Schmaltz, Achim A. Erwachsene mit angeborenen Herzfehlern (EMAH): S2-Leitlinie der DGK, DGPK und DGTHG zur Diagnostik und Therapie in Klinik und Praxis ; mit 9 Tabellen. Steinkopff, 2008.

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Schmaltz, Achim A. Erwachsene Mit Angeborenen Herzfehlern: S2-Leitlinie der DGK, DGPK und DGTHG Zur Diagnostik und Therapie in Klinik und Praxis. Steinkopff, Dietrich, 2008.

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Book chapters on the topic "DGKκ"

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Gressner, A. M., and O. A. Gressner. "Klinische(r) Chemiker(in) (DGKL)." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_1699-1.

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Gressner, A. M., and O. A. Gressner. "Klinische(r) Chemiker(in) (DGKL)." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_1699.

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Gressner, A. M., and O. A. Gressner. "Deutsche Gesellschaft für Klinische Chemie e.V. (DGKC)." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_863.

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Gressner, A. M., and O. A. Gressner. "Deutsche Gesellschaft für Klinische Chemie e.V. (DGKC)." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_863-1.

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Gressner, A. M., and O. A. Gressner. "Deutsche Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL)." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_867.

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Gressner, A. M., and O. A. Gressner. "Deutsche Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL)." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_867-1.

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Shirai, Yasuhito, and Naoaki Saito. "Diacylglycerol Kinase (DGK) as a Regulator of PKC." In Protein Kinase Technologies. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-824-5_15.

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Schepker, Klaus, and Heiner Fangerau. "Die Gründungsgeschichte der Deutschen Gesellschaft für Kinderpsychiatrie und Heilpädagogik (DGKH) und ihr Wirken." In Kinder- und Jugendpsychiatrie im Nationalsozialismus und in der Nachkriegszeit. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49806-4_2.

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Arisz, Steven A., and Teun Munnik. "Distinguishing Phosphatidic Acid Pools from De Novo Synthesis, PLD, and DGK." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-401-2_6.

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"DGKC." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_311015.

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Conference papers on the topic "DGKκ"

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Schweickert, Patrick G., Gabrielle L. Reiner, Casey G. Mitchell та ін. "1385 Dual Inhibition of DGKα and DGKζ increases T cell and NK cell activity". У SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.1385.

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Wee, Susan, Junchen Gu, Cindy Wang та ін. "Abstract 936: Regulation of CD8+ T-cell function and antitumor activity by DGKα and DGKζ". У Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-936.

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Wee, Susan, Junchen Gu, Cindy Wang та ін. "Abstract 936: Regulation of CD8+ T-cell function and antitumor activity by DGKα and DGKζ". У Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-936.

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Veugen, Thijs. "Improving the DGK comparison protocol." In 2012 IEEE International Workshop on Information Forensics and Security (WIFS). IEEE, 2012. http://dx.doi.org/10.1109/wifs.2012.6412624.

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Offringa, Rienk, Catherine Olesch, Frederik Cichon, et al. "737 Optimal enhancement of anti-tumor T-cell immunity through the combined use of selective DGK zeta and DGK alpha inhibitors." In SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.0737.

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Yadav, S., S. S. Shah, S. Pan, B. Singh, T. Kambayashi, and D. A. Deshpande. "Diacylglycerol Kinase (DGK) Regulation of Airway Smooth Muscle Contraction." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4285.

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Wang, Adele, Lance Stapleton, Jean-Philippe Belzie та ін. "1066 Pharmacologic inhibition of DGKα activates T cells and enhances anti-tumor immunity". У SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1066.

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Li, Jie, Chaoyun Pan, Austin C. Boese, Anna Umano, and Sumin Kang. "Abstract 4084: A DGKA-cJUN-WEE1 signaling axis provides platinum resistance in ovarian cancer." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-4084.

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Bahadori, Milad, and Kimmo Jarvinen. "A Programmable SoC Implementation of the DGK Cryptosystem for Privacy-Enhancing Technologies." In 2020 23rd Euromicro Conference on Digital System Design (DSD). IEEE, 2020. http://dx.doi.org/10.1109/dsd51259.2020.00049.

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Offringa, Rienk, Catherine Olesch, Frederik Cichon, et al. "926 BAY 2965501: a highly selective DGK zeta inhibitor for cancer immunotherapy." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0926.

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