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Journal articles on the topic 'DHA oil'

Author: Grafiati

Published: 2 July 2022

Last updated: 31 July 2025

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1

Yang, Zhi-Hong, Marcelo Amar, Maureen Sampson, et al. "Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults." Nutrients 12, no. 3 (2020): 749. http://dx.doi.org/10.3390/nu12030749.

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Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have both shared and different cardiovascular effects, and commonly used fish oil supplements have considerably varied EPA/DHA ratios. Aims: We compared the effects of fish oil supplements with different EPA/DHA ratios on lipoprotein metabolism. Methods: In a double-blind, randomized cross-over study, normolipidemic adults (n = 30) consumed 12 g/day of EPA-rich (EPA/DHA: 2.3) or DHA-rich (EPA/DHA: 0.3) fish oil for 8-weeks, separated by an 8-week washout period. Results: Both fish oil supplements similarly lowered plasma TG

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Miralles-Pérez, Bernat, Lucía Méndez, Maria Rosa Nogués, et al. "Effects of a Fish Oil Rich in Docosahexaenoic Acid on Cardiometabolic Risk Factors and Oxidative Stress in Healthy Rats." Marine Drugs 19, no. 10 (2021): 555. http://dx.doi.org/10.3390/md19100555.

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Omega-3 polyunsaturated fatty acids are associated with a lower risk of cardiometabolic diseases. However, docosahexaenoic acid (DHA) is easily oxidized, leading to cellular damage. The present study examined the effects of an increased concentration of DHA in fish oil (80% of total fatty acids) on cardiometabolic risk factors and oxidative stress compared to coconut oil, soybean oil, and fish oil containing eicosapentaenoic acid (EPA) and DHA in a balanced ratio. Forty healthy male Sprague–Dawley rats were supplemented with corresponding oil for 10 weeks. Supplementation with the fish oil con

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Nauroth, Julie Marie, Mary Van Elswyk, Ying Liu, and Linda Arterburn. "Anti-inflammatory activity of algal oils containing Docosahexaenoic Acid (DHA) and omega-6 Docosapentaenoic Acid (DPAn-6) (101.5)." Journal of Immunology 178, no. 1_Supplement (2007): S201. http://dx.doi.org/10.4049/jimmunol.178.supp.101.5.

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Abstract Background: Studies have shown anti-inflammatory activity associated with fish oil and ascribed this effect to the long-chain omega-3 fatty acids DHA and especially eicosapentaenoic acid (EPA). Objective: The purpose of this study was to examine the anti-inflammatory effects of DHA-rich algal oils which contain little or no EPA and determine the contribution of their individual constituent fatty acids, particularly DHA and DPAn-6. Results: The effects of feeding DHA-rich Martek DHA-T™ algal oil and DHA/DPAn-6-rich Martek DHA-S™ algal oil on rat carrageenan-induced hind paw edema was e

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4

Ghasemi Fard, Samaneh, Su Peng Loh, Giovanni M. Turchini, Bo Wang, Glenn Elliott, and Andrew J. Sinclair. "Microencapsulated Tuna Oil Results in Higher Absorption of DHA in Toddlers." Nutrients 12, no. 1 (2020): 248. http://dx.doi.org/10.3390/nu12010248.

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Docosahexaenoic acid (DHA) is an essential component for brain and visual acuity development during foetal and early postnatal life. A newly released directive under the European Commission stipulates DHA as a mandatory ingredient in infant formula. This poses challenges to manufacturers in preserving the stability and bioavailability of DHA at levels akin to human breast milk. The aims of this study were (a) to investigate the bioavailability of microencapsulated omega-3 DHA formulations in healthy toddlers compared with high DHA fish oil for a one-month period and (b) to assess the effect of

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Sugasini, Dhavamani, Poorna C. R. Yalagala, and Papasani V. Subbaiah. "Efficient Enrichment of Retinal DHA with Dietary Lysophosphatidylcholine-DHA: Potential Application for Retinopathies." Nutrients 12, no. 10 (2020): 3114. http://dx.doi.org/10.3390/nu12103114.

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Although decreased retinal docosahexaenoic acid (DHA) is a known risk factor for retinopathy, currently available omega-3 fatty acid supplements, which are absorbed as triacylglycerol (TAG), do not significantly enrich retinal DHA. We tested the hypothesis that lysophospahtidylcholine (LPC)-DHA which is absorbed as phospholipid, would efficiently increase retinal DHA because of the presence of LPC-specific transporter at the blood–retina barrier. In normal rats, LPC-DHA and di-DHA phosphatidylcholine (PC), which generates LPC-DHA during digestion, increased retinal DHA by 101% and 45%, respect

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Jiang, Xiaodong, Kewu Pan, Yuhong Yang, Alexander Chong Shu-Chien, and Xugan Wu. "Dietary DHA Oil Supplementation Promotes Ovarian Development and Astaxanthin Deposition during the Ovarian Maturation of Chinese Mitten Crab Eriocheir sinensis." Aquaculture Nutrition 2022 (April 9, 2022): 1–23. http://dx.doi.org/10.1155/2022/9997317.

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Astaxanthin (Axn) is an essential carotenoid for crustacean pigmentation, and docosahexaenoic acid (DHA) is an important fatty acid; both play key roles in maintaining the health of many aquaculture species. The present study explored the combined effect of dietary Axn and DHA on gonadal development and carotenoid deposition in adult females of the Chinese mitten crab, Eriocheir sinensis. A 2 × 3 factorial design of experimental diets was created to contain two levels of Axn (0 mg/kg and 100 mg/kg) and three levels of DHA oil (0%, 0.33%, and 0.67%). The results showed as follows: (1) For the c

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7

Rymer, C., C. Dyer, D. I. Givens, and R. Allison. "Relationship between fish oil intake by dairy cows and the yield of eicosapentaenoic acid and docosahexaenoic acid in their milk." Proceedings of the British Society of Animal Science 2001 (2001): 199. http://dx.doi.org/10.1017/s1752756200005810.

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The dietary essential fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are predominantly found in fish oil, but fish consumption in the UK is low. Increasing the yield of EPA and DHA in cows’ milk would increase human intakes of EPA and DHA, and this can be achieved by including fish oil in cows’ diets. However, because EPA and DHA are susceptible to rumen biohydrogenation, their transfer efficiency into milk is low.In vitroobservations by Gulatiet al. (1999) suggested that if the concentration of fish oil in the rumen exceeded 1 mg/ml, EPA and DHA were not hydrogenated.

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8

Motsinger, Laura A., Catherine Kalmbach, Dale Fritsch, Nasson Mwakatage, and Leslie B. Hancock. "PSIX-6 Algal oil as an alternative source of docosahexaenoic acid in feline diets." Journal of Animal Science 102, Supplement_3 (2024): 574. http://dx.doi.org/10.1093/jas/skae234.645.

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Abstract The global demand for eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation by humans and their necessity in companion animal foods has raised questions related to environmental sustainability and nutrient content of fish oil. The combination of reported diminishing EPA and DHA content in fish oil and the forecasting of a significant decline in global fish stocks over the next decade make it critical to consider alternative sources of omega-3 fatty acids to reduce dependence on fish harvests. Cultured algal oil has been identified as a promising and viable alterna

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Zhang, Yuqing, Zuohua Xie, Siqiong Zhang, Jing Li, and Ting Luo. "Preparation of Low-Fishy Microencapsulated DHA-Rich Algal Oil Powder Using Infant Rice Powder." Foods 13, no. 23 (2024): 3827. http://dx.doi.org/10.3390/foods13233827.

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Commercial DHA-rich algal oil has some issues, such as an unpleasant odor and susceptibility to oxidation. The main fishy odor compounds in commercial DHA-rich algal oil powder and DHA-rich algal oil microcapsules are hexanal and (E, E)-2,4-heptadienal. To address this issue, a microencapsulation process was designed for DHA-rich algal oil using infant rice powder (IRP), maltodextrin (MD), and whey protein concentrate (WPC) as wall materials, with sodium starch octenyl succinate (SSOS) and monoacylglycerol (MAC) as emulsifiers. The spray-drying method was used for microencapsulation. The exper

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AbuKhader, Majed, Mohammad Al-Ghazali, Salma Khamis Ali, Ismael Merie, and Aya Bouazza. "The Eicosapentaenoic Acid and Docosahexaenoic Acid Content Reported in the Nutrition Panel of Fish Oil Supplements and Formula Milks Promoted for Young Children in Selected Markets." Nutrition Today 58, no. 6 (2023): 244–50. http://dx.doi.org/10.1097/nt.0000000000000654.

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The aim of this study was to investigate the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) content found in fish oil supplements and formula milks for young children sold in Europe, the Middle East, and North Africa's local markets and online stores. To allow comparison of fish oil supplements and formula milks, information about the EPA and DHA content was collected from the nutrition panel of each product. A total of 79 fish oil supplements and 70 formula milks were studied. Out of the 32 fish oil supplements in local markets 12 products (37.5%) and of the 47 fish oil supplement

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11

Wayne, Laura L., Daniel J. Gachotte, Paul R. Graupner, et al. "Plant and algal lysophosphatidic acid acyltransferases increase docosahexaenoic acid accumulation at the sn-2 position of triacylglycerol in transgenic Arabidopsis seed oil." PLOS ONE 16, no. 8 (2021): e0256625. http://dx.doi.org/10.1371/journal.pone.0256625.

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Although docosahexaenoic acid (DHA), an important dietary omega-3 polyunsaturated fatty acid (PUFA), is at present primarily sourced from marine fish, bioengineered crops producing DHA may offer a more sustainable and cost-effective source. DHA has been produced in transgenic oilseed crops, however, DHA in seed oil primarily occupies the sn-1/3 positions of triacylglycerol (TAG) with relatively low amounts of DHA in the sn-2 position. To increase the amount of DHA in the sn-2 position of TAG and in seed oil, putative lysophosphatidic acid acyltransferases (LPAATs) were identified and character

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12

Geppert, Julia, Veronika Kraft, Hans Demmelmair, and Berthold Koletzko. "Microalgal docosahexaenoic acid decreases plasma triacylglycerol in normolipidaemic vegetarians: a randomised trial." British Journal of Nutrition 95, no. 4 (2006): 779–86. http://dx.doi.org/10.1079/bjn20051720.

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Triacylglycerol (TG) lowering effects ofn−3 long-chain PUFA (n−3 LCPUFA) have been repeatedly demonstrated, but studies investigating the individual effects of EPA or DHA on plasma TG and lipoproteins in man are rare. The effects of a new DHA-rich, almost EPA-free microalgae oil (Ulkeniasp.) on plasma lipids and several safety parameters were investigated in a double-blind, placebo-controlled, parallel design intervention study. Normolipidaemic vegetarians (eighty-seven females, twenty-seven males) consumed daily microalgae oil (0·94g DHA/d) or olive oil (as placebo) for 8 weeks. DHA supplemen

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13

Yin, Fengwei, Xiaolong Sun, Xi Luo, et al. "A Review on Marine Microbial Docosahexaenoic Acid Production Through Circular Economy, Fermentation Engineering, and Antioxidant Technology." Marine Drugs 23, no. 6 (2025): 256. https://doi.org/10.3390/md23060256.

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Marine microbial-derived docosahexaenoic acid (DHA) has garnered significant attention as a sustainable and health-promoting alternative to fish oil-derived DHA. However, its industrial production from marine heterotrophic microorganisms faces challenges related to high costs and suboptimal oil quality, which hinder its broader application. This review focuses on recent strategies aimed at achieving low-cost and high-quality marine microbial DHA production, emphasizing heterotrophic systems that dominate commercial supply. Key aspects include: Fermentation optimization using waste-derived feed

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14

CHENG, C. H., T. F. SHEN, W. L. CHEN, and S. T. DING. "Effects of dietary algal docosahexaenoic acid oil supplementation on fatty acid deposition and gene expression in laying Leghorn hens." Journal of Agricultural Science 142, no. 6 (2004): 683–90. http://dx.doi.org/10.1017/s0021859605004867.

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The purpose of the current study was to determine the effects of dietary docosahexaenoic acid (DHA) on fatty acid deposition in egg yolk and various tissues of laying Leghorn hens, and on the expression of hepatic lipogenesis-related transcription factors. There were three treatments with 10 Leghorn hens per treatment. Diets were based on maize-soybean meal (ME: 12 MJ/kg; CP: 171 g/kg; Ca: 34 g/kg) supplemented with 0 (plus 20 g butter/kg), 5 g (plus 15 g butter/kg) or 20 g algal DHA oil/kg. The egg production of the birds was not affected by dietary DHA oil (P>0·05). The DHA content in egg

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15

Patan, Michael J., David O. Kennedy, Cathrine Husberg, et al. "Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials." American Journal of Clinical Nutrition 114, no. 3 (2021): 914–24. http://dx.doi.org/10.1093/ajcn/nqab174.

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ABSTRACT Background Evidence regarding the effects of the omega-3 (ɷ-3) PUFAs (n–3 PUFAs) DHA and EPA on cognition is lacking. Objectives We investigated whether supplementation with oils rich in EPA or DHA improves cognition, prefrontal cortex (PFC) hemoglobin (Hb) oxygenation, and memory consolidation. Methods Healthy adults (n = 310; age range: 25–49 y) completed a 26-wk randomized controlled trial in which they consumed either 900 mg DHA/d and 270 mg EPA/d (DHA-rich oil), 360 mg DHA/d and 900 mg EPA/d (EPA-rich oil), or 3000 mg/d refined olive oil (placebo). Cognitive performance and memor

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16

Belobrajdic, Damien P., Julie A. Dallimore, Michael J. Adams, Surinder P. Singh та Mahinda Y. Abeywardena. "Sn1,3 Regiospecificity of DHA (22:6ω-3) of Plant Origin (DHA-Canola®) Facilitates Its Preferential Tissue Incorporation in Rats Compared to sn2 DHA in Algal Oil at Low Dietary Inclusion Levels". Nutrients 17, № 8 (2025): 1306. https://doi.org/10.3390/nu17081306.

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Background/Objectives: Regiospecificity in triacylglycerols (TAGs) influences absorption/bioavailability of dietary fatty acids. We evaluated whether sn1,3 located DHA (22:6ω3) of a transgenic higher plant (DHA-Canola®) preferentially facilitates its tissue incorporation as compared to sn2 positioned DHA (DHASCO® of algal origin). Methods: Sprague Dawley rats were fed diets (12 weeks) containing DHA-Canola or DHA-Control (a blend of DHASCO® and high oleic sunflower seed oil (HOSO)) at 0.3%, 1%, 3%, and 6% (w/w), or 7% HOSO prior to determination of tissue fatty acids. Results: At 0.3 and 1% w/

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17

Yang, Ge, Liu Yan, and Ming Gao. "Effects of pH and Aeration on the Production of Docosahexaenoic Acid by Thraustochytrium aureum in Controlled Batch Fermentor Cultures." Advanced Materials Research 183-185 (January 2011): 50–54. http://dx.doi.org/10.4028/www.scientific.net/amr.183-185.50.

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Docosahexaenoic acid (DHA. C22:6 ω-3) is an important structural component of neural and retinal tissues .The DHA yield was highest at pH5.5. Glucose and maltose utilization were similar as a function of pH, linseed oil consumption increased at pH 5.5, indicating that the formation of DHA from linseed oil at pH5.5 was of increased importance. Increased aeration resulted in doubling of T. aureum cell dry weights, increasing DHA yields and increasing in the maximum DHA -specific production rate .

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Lestari, L. A., L. Fadilah, M. E. Anchaelsi, N. N. Yasmin, T. Estiasih, and S. H. Suseno. "Immunomodulatory effect of fish oil and its polyunsaturated fatty acid components." Food Research 8, no. 1 (2024): 52–62. http://dx.doi.org/10.26656/fr.2017.8(1).940.

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Trends in purchasing functional foods and pharmaceutical products as immune boosters in Indonesia have begun to increase due to the current COVID-19 pandemic situation. One of them is fish oil, which is known as the oil with the highest polyunsaturated fatty acids (PUFA) content compared to other oils, especially eicosapentaenoic acids (EPA) and docosahexaenoic acids (DHA) are well-known to have many health benefits. EPA and DHA also act as immunomodulators to maintain the immune system. It is shown by the presence of anti-inflammatory, vasodilating, anti-arrhythmic, and anti-aggregation effec

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Li, Jin, Yaqiong Jian, Ruonan Liu, et al. "Choline and Fish Oil Can Improve Memory of Mice through Increasing Brain DHA Level." Foods 12, no. 9 (2023): 1799. http://dx.doi.org/10.3390/foods12091799.

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Docosahexaenoic acid (DHA) is highly enriched in the brain, and is essential for normal brain development and function. However, evidence suggests that currently used supplements, such as fish oil, do not significantly increase brain DHA levels. Therefore, this study aimed to investigate whether combined fish oil and choline supplementation could affect the type and enrich the content of DHA in the brain. The results revealed that the combined intake of fish oil and choline upregulated the expression of key transporters and receptors, including MFSD2A, FATP1, and FABP5, which increased the upt

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Moreno, Francisco, Lucía Méndez, Ingrid Fernández, et al. "Influence of the Degree of Unsaturation in Fish Oil Supplements on Oxidative Stress and Protein Carbonylation in the Cerebral Cortex and Cerebellum of Healthy Rats." Antioxidants 13, no. 11 (2024): 1408. http://dx.doi.org/10.3390/antiox13111408.

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ω-3 polyunsaturated fatty acids (PUFAs) are crucial for brain structure and function, especially docosahexaenoic acid (DHA). However, an excess of DHA may increase lipid peroxidation due to its high degree of unsaturation, particularly in tissues highly susceptible to oxidative stress, such as the brain. Therefore, this study evaluated the effects of 10 weeks of dietary supplementation with fish oil containing 80% DHA on oxidative stress and the modulation of the carbonylated proteome in both the cerebral cortex and cerebellum of male Sprague Dawley rats. The results were compared with those i

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Lim, Sun-Young, and Hiramitsu Suzuki. "Dose-Response Effect of Docosahexaenoic Acid Ethyl Ester on Maze Behavior and Brain Fatty Acid Composition in Adult Mice." International Journal for Vitamin and Nutrition Research 72, no. 2 (2002): 77–84. http://dx.doi.org/10.1024/0300-9831.72.2.77.

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The dose-response effect of dietary docosahexaenoic acid (DHA, 22:6 n-3) ethyl ester (EE) on maze-learning ability in mice was studied. Male Crj:CD-1 mice aged three months were fed a) a diet containing 5 g palm oil/100 g diet (control group); b) a diet containing 0.5 g DHA ethyl ester/100 g diet plus 4.5 g palm oil/100g diet (DHA-EE 0.5% group); c) a diet containing 1g DHA ethyl ester/100 g diet plus 4g palm oil/100 g diet (DHA-EE 1% group); d) a diet containing 2 g DHA ethyl ester/100 g diet plus 3 g palm oil/100 g diet (DHA-EE 2% group) for four months. Maze-learning ability was assessed th

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Lim, Sun-Young, and Hiramitsu Suzuki. "Effect of Dietary Docosahexaenoic Acid and Phosphatidylcholine on Maze Behavior and Fatty Acid Composition of Plasma and Brain Lipids in Mice." International Journal for Vitamin and Nutrition Research 70, no. 5 (2000): 251–59. http://dx.doi.org/10.1024/0300-9831.70.5.251.

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We investigated the effects of dietary docosahexaenoic acid (DHA, 22:6 n-3) and phosphatidylcholine (PC) on maze behavior and brain fatty acids in mice. Male Crj:CD-1 mice (3 wk old) were fed a diet containing 2% DHA and 3% palm oil (DHA group); 5% PC (PC group); 1% DHA, 2.5% PC and 1.5% palm oil (DHA+PC group); 5% palm oil (Palm oil control group) or MF laboratory chow (MF control group) for 7 mo. After this time maze-learning ability was assessed. The time required to reach the maze exit and the number of times that a mouse strayed into blind alleys in the maze were measured three times ever

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West, Annette L., Elizabeth A. Miles, Karen A. Lillycrop, et al. "Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans." British Journal of Nutrition 121, no. 11 (2019): 1235–46. http://dx.doi.org/10.1017/s0007114519000825.

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AbstractEPA and DHA are important components of cell membranes. Since humans have limited ability for EPA and DHA synthesis, these must be obtained from the diet, primarily from oily fish. Dietary EPA and DHA intakes are constrained by the size of fish stocks and by food choice. Seed oil from transgenic plants that synthesise EPA and DHA represents a potential alternative source of these fatty acids, but this has not been tested in humans. We hypothesised that incorporation of EPA and DHA into blood lipids from transgenic Camelina sativa seed oil (CSO) is equivalent to that from fish oil. Heal

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West, Annette L., Elizabeth A. Miles, Karen A. Lillycrop, et al. "Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte DHA and EPA to fish oil in healthy humans." British Journal of Nutrition 124, no. 9 (2020): 922–30. http://dx.doi.org/10.1017/s0007114520002044.

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AbstractEPA and DHA are required for normal cell function and can also induce health benefits. Oily fish are the main source of EPA and DHA for human consumption. However, food choices and concerns about the sustainability of marine fish stocks limit the effectiveness of dietary recommendations for EPA + DHA intakes. Seed oils from transgenic plants that contain EPA + DHA are a potential alternative source of EPA and DHA. The present study investigated whether dietary supplementation with transgenic Camelina sativa seed oil (CSO) that contained EPA and DHA was as effective as fish oil (FO) in

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Shin, Kyung-Chul, Tae-Eui Lee, Su-Eun Kim, Yoon-Joo Ko, Min-Ju Seo, and Deok-Kun Oh. "Enzymatic Formation of Protectin Dx and Its Production by Whole-Cell Reaction Using Recombinant Lipoxygenases." Catalysts 12, no. 10 (2022): 1145. http://dx.doi.org/10.3390/catal12101145.

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In the human body, docosahexaenoic acid (DHA) contained in fish oil is converted to trace amounts of specialized pro-resolving mediators (SPMs) as the principal bioactive metabolites for their pharmacological effects. Protectin Dx (PDX), an SPM, is an important medicinal compound with biological activities such as modulation of endogenous antioxidant systems, inflammation pro-resolving action, and inhibition of influenza virus replication. Although it can be biotechnologically synthesized from DHA, it has not yet been produced quantitatively. Here, we found that 15S-lipoxygenase from Burkholde

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Kolar, Satya Sree N., Rola Barhoumi, Evelyn S. Callaway, et al. "Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca2+ accumulation in colonocytes." American Journal of Physiology-Gastrointestinal and Liver Physiology 293, no. 5 (2007): G935—G943. http://dx.doi.org/10.1152/ajpgi.00312.2007.

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Butyrate, a short-chain fatty acid fiber fermentation product, induces colonocyte apoptosis in part via a Fas-mediated (extrinsic) pathway. In previous studies, we demonstrated that docosahexaenoic acid (DHA, 22:6Δ4,7,10,13,16,19) enhances the effect of butyrate by increasing mitochondrial lipid oxidation and mitochondrial Ca2+-dependent apoptosis in the colon. In this study, we further examined the mechanism of DHA-butyrate synergism in 1) human colon tumor (HCT-116 isogenic p53+/+ vs. p53−/−) cells and 2) primary cultures of rat colonic crypts. Herein, we show that DHA and butyrate promote a

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Chin, H. J., Y. H. Ko, T. F. Shen, and S. T. Ding. "The effect of dietary docosahexaenoic acid on the expression of lipogenic genes in broilers." Australian Journal of Agricultural Research 58, no. 2 (2007): 153. http://dx.doi.org/10.1071/ar05399.

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The objectives of this work were to determine the effects of dietary fungal docosahexaenoic acid (DHA) on tissue DHA concentration and lipogenic gene expression in broilers. A fungal (SR-21) meal product containing 31.5% total fat and 32.7% DHA (% of total fatty acids) was fed to chicken broilers at 0, 1, or 3% for 3 weeks. A diet with 1% DHA oil (containing 40% DHA) was also fed to chicken broilers as a positive control. Dietary fungal meal supplementation (3%) improved daily weight gain, food intake, and feed conversion ratio. The fungal meal supplementation increased dietary DHA content and

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Ruyter, Bente, Nini H. Sissener, Tone-Kari Østbye, et al. "n-3 Canola oil effectively replaces fish oil as a new safe dietary source of DHA in feed for juvenile Atlantic salmon." British Journal of Nutrition 122, no. 12 (2019): 1329–45. http://dx.doi.org/10.1017/s0007114519002356.

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AbstractLimited availability of fish oils (FO), rich in n-3 long-chain (≥C20) PUFA, is a major constraint for further growth of the aquaculture industry. Long-chain n-3 rich oils from crops GM with algal genes are promising new sources for the industry. This project studied the use of a newly developed n-3 canola oil (DHA-CA) in diets of Atlantic salmon fingerlings in freshwater. The DHA-CA oil has high proportions of the n-3 fatty acids (FA) 18 : 3n-3 and DHA and lower proportions of n-6 FA than conventional plant oils. Levels of phytosterols, vitamin E and minerals in the DHA-CA were within

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Peskin, B. S. "Why Fish Oil Fails: A Comprehensive 21st Century Lipids-Based Physiologic Analysis." Journal of Lipids 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/495761.

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The medical community suffered three significant fish oil failures/setbacks in 2013. Claims that fish oil’s EPA/DHA would stop the progression of heart disease were crushed when The Risk and Prevention Study Collaborative Group (Italy) released a conclusive negative finding regarding fish oil for those patients with high risk factors but no previous myocardial infarction. Fish oil failed in all measures of CVD prevention—both primary and secondary. Another major 2013 setback occurred when fish oil’s DHA was shown to significantly increase prostate cancer in men, in particular, high-grade prost

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Davidson, Eric, Oleksandr Obrosov, Lawrence Coppey, and Mark Yorek. "Omega-3 Polyunsaturated Fatty Acids (PUFAs) and Diabetic Peripheral Neuropathy: A Pre-Clinical Study Examining the Effect of Omega-3 PUFAs from Fish Oil, Krill Oil, Algae or Pharmaceutical-derived Ethyl Esters Using Type 2 Diabetic Rats." Biomedicines 13, no. 7 (2025): 1607. https://doi.org/10.3390/biomedicines13071607.

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Background and Objectives: We have previously reported that omega-3 polyunsaturated fatty acids (PUFAs) derived from fish oil (FO) is an effective treatment for type 1 and type 2 diabetes neural and vascular complications. As omega-3 PUFAs become more widely used as a nutritional and disease modifying supplement an important question to be addressed is what is the preferred source of omega-3 PUFAs? Methods: Using a type 2 diabetic rat model and early and late intervention protocols we examined the effect of dietary treatment with omega-3 PUFAs derived from menhaden (fish) oil (MO), krill oil (

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Couëdelo, Leslie, Stephanie Lennon, Hélène Abrous, et al. "In Vivo Absorption and Lymphatic Bioavailability of Docosahexaenoic Acid from Microalgal Oil According to Its Physical and Chemical Form of Vectorization." Nutrients 16, no. 7 (2024): 1014. http://dx.doi.org/10.3390/nu16071014.

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Docosahexaenoic acid (DHA) is an essential fatty acid (FA) with proven pro-health effects, but improving its bioavailability is becoming a public health issue. The bioavailability of DHA from microalgal (A) oil has been comprehensively assessed, particularly in terms of the molecular structuring capabilities offered by A-oil. Here, we explored the impact of five DHA-rich formulas differing in terms of (i) molecular structure, i.e., ethyl ester (EE), monoglyceride (MG), or triglyceride (TG), and (ii) supramolecular form, i.e., emulsified TG or TG + phospholipids (PL blend) on the lymphatic kine

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Yin, Fengwei, Xiaolong Sun, Weilong Zheng, et al. "Screening of highly effective mixed natural antioxidants to improve the oxidative stability of microalgal DHA-rich oil." RSC Advances 11, no. 9 (2021): 4991–99. http://dx.doi.org/10.1039/d0ra10312h.

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Antioxidants with synergistic effect were screened and optimized by RSM. The final natural antioxidant mixture can be actually applied in micrialgal DHA-rich oil, helping to enhance the antioxidant ability of DHA oil and extend its shelf life.

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Thota, Rohith N., Jessica I. Rosato, Tracy L. Burrows, et al. "Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults." Nutrients 12, no. 6 (2020): 1612. http://dx.doi.org/10.3390/nu12061612.

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Targeting kinases linked to insulin resistance (IR) and inflammation may help in reducing the risk of type 2 diabetes (T2D) and Alzheimer’s disease (AD) in its early stages. This study aimed to determine whether DHA-rich fish oil supplementation reduces glycogen synthase kinase (GSK-3), which is linked to both IR and AD. Baseline and post-intervention plasma samples from 58 adults with abdominal obesity (Age: 51.7 ± 1.7 years, BMI: 31.9 ± 0.8 kg/m2) were analysed for outcome measures. Participants were allocated to 2 g DHA-rich fish oil capsules (860 mg DHA + 120 mg EPA) (n = 31) or placebo ca

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Østbye, Tone-Kari Knutsdatter, Oddrun Anita Gudbrandsen, Aslaug Drotningsvik, et al. "Different Dietary Ratios of Camelina Oil to Sandeel Oil Influence the Capacity to Synthesise and Deposit EPA and DHA in Zucker Fa/Fa Rats." Nutrients 15, no. 10 (2023): 2344. http://dx.doi.org/10.3390/nu15102344.

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Plant-based food provides more ALA (α-linolenic acid) and less EPA (eicosapentaenoic acid) and DHA (docosahexanoic acid) than marine food. Earlier studies indicate that cetoleic acid (22:1n-11) stimulates the n-3 pathway from ALA to EPA and DHA. The present study aimed to investigate the dietary effects of camelina oil (CA) high in ALA and sandeel oil (SA) high in cetoleic acid on the conversion of ALA to EPA and DHA. Male Zucker fa/fa rats were fed a diet of soybean oil (Ctrl) or diets of CA, SA, or a combination of CA and SA. Significantly higher levels of DPA (docosapentaenoic acid) and DHA

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Mavrommatis, Yiannis, Karen Ross, Garry Rucklidge, et al. "Intervention with fish oil, but not with docosahexaenoic acid, results in lower levels of hepatic soluble epoxide hydrolase with time in apoE knockout mice." British Journal of Nutrition 103, no. 1 (2009): 16–24. http://dx.doi.org/10.1017/s0007114509991450.

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Long-chain n-3 PUFA from fish oil protect against death from CHD but mechanisms are not well understood. Preliminary results indicate that fish oil may affect the enzyme soluble epoxide hydrolase (sEH) and influence inflammatory pathways in a time-dependent manner. In the present study male apoE knockout (Apoe− / − ) mice were randomised to three dietary groups receiving a high-fat high-cholesterol diet supplemented with 2 % (w/w) high-oleic acid sunflower-seed (HOSF) oil, DHA oil or fish oil. Livers and proximal aortas were collected on day 2 and on weeks 1, 2, 4 and 10 to determine hepatic s

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Wang, Cheng-Cheng, Ying Guo, Miao-Miao Zhou, et al. "Comparative studies of DHA-enriched phosphatidylcholine and recombination of DHA-ethyl ester with egg phosphatidylcholine on ameliorating memory and cognitive deficiency in SAMP8 mice." Food & Function 10, no. 2 (2019): 938–50. http://dx.doi.org/10.1039/c8fo01822g.

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He, Zude, Wei Xiong, Yue Yang, et al. "Lipidomics Analysis Reveals the Effects of Docosahexaenoic Acid from Different Sources on Prefrontal-Cortex Synaptic Plasticity." Nutrients 17, no. 3 (2025): 457. https://doi.org/10.3390/nu17030457.

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Background: Docosahexaenoic Acid (DHA) is an extensively used nutrition supplement in dairy food because of its beneficial effects on cognition. To find an effective DHA intervention for the synapses in the cortex during this period, this study aimed to use targeted lipidomics to evaluate the lipid composition of prefrontal-cortex (PFC) tissue in different DHA interference methods. Methods: Analyzed samples were taken from interfering feeding Bama pigs (BPs) (3 months) fed with soybean oil (Group B), blended oil (Group M), naturally DHA-supplemented milk with blended oil (Group OM), and DHA fr

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Takeyama, Islam, Watanabe, et al. "Dietary Intake of Green Nut Oil or DHA Ameliorates DHA Distribution in the Brain of a Mouse Model of Dementia Accompanied by Memory Recovery." Nutrients 11, no. 10 (2019): 2371. http://dx.doi.org/10.3390/nu11102371.

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Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has significant healthbenefits. Previous studies reported decreased levels of DHA and DHA-containing phosphatidylcholines inthe brain of animals suffering from Alzheimer’s disease, the most common type of dementia; furthermore,DHA supplementation has been found to improve brain DHA levels and memory efficiency in dementia. Oilextracted from the seeds of Plukenetia volubilis (green nut oil; GNO) is also expected to have DHA like effectsas it contains approximately 50% α-linolenic acid, a precursor of DHA. Despite this, changes i

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Arfan, Tafdlilul, Harmita ., and Baitha Palanggatan Maggadani. "ANALYSIS OF ALPHA-LINOLENIC ACID AND DOCOSAHEXAENOIC ACID IN MACKEREL FISH OIL (RASTRELLIGER KANAGURTA) USING GAS CHROMATOGRAPHY." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 28. http://dx.doi.org/10.22159/ijap.2018.v10s1.07.

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Objective: This study aimed to obtain the levels of alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) in mackerel fish oil by pressing andextraction with solvent methods.Methods: The optimum conditions were determined, and validation methods were performed for a mixture of ALA and DHA to obtain a valid methodfor the determination of the levels of ALA and DHA in mackerel fish oil. Derivatization was performed by the Lepage esterification method usingmethanol:toluene 4:1 (v/v) and an acetyl chloride catalyst. Gas chromatography with the Shimadzu GC-17A with a DB-5 column and flame ioniza

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Kagan, Michael L., Aharon Levy, and Alicia Leikin-Frenkel. "Comparative study of tissue deposition of omega-3 fatty acids from polar-lipid rich oil of the microalgae Nannochloropsis oculata with krill oil in rats." Food & Function 6, no. 1 (2015): 185–91. http://dx.doi.org/10.1039/c4fo00591k.

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An oil from micro-algae rich in EPA with no DHA and consisting of 15% polar lipids (phospholipids and glycolipids) showed equivalent uptake of EPA into rat plasma and organs as omega-3 krill oil consisting of EPA and DHA and 40% phospholipids.

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Silva, Carla, Patricia Moniz, Ana Cristina Oliveira, Samuela Vercelli, Alberto Reis, and Teresa Lopes da Silva. "Cascading Crypthecodinium cohnii Biorefinery: Global Warming Potential and Techno-Economic Assessment." Energies 15, no. 10 (2022): 3784. http://dx.doi.org/10.3390/en15103784.

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Prior to the commissioning of a new industrial biorefinery it is deemed necessary to evaluate if the new project will be beneficial or detrimental to climate change, one of the main drivers for the sustainable development goals (SDG) of the United Nations. In particular, how SDG 7, Clean and Efficient Energy, SDG 3, Good Health and Well Being, SDG 9, Industry Innovation and Infrastructure, and SDG 12, Responsible Production and Consumption, would engage in a new biorefinery design, beneficial to climate change, i.e., fostering SDG 13, Climate Action. This study uses life cycle assessment metho

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Singh, Harmanpreet, Shubham Thakur, Nikhil Shri Sahajpal, et al. "Recent Advances in the Novel Formulation of Docosahexaenoic Acid for Effective Delivery, Associated Challenges and Its Clinical Importance." Current Drug Delivery 17, no. 6 (2020): 483–504. http://dx.doi.org/10.2174/1567201817666200512103402.

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Docosahexaenoic Acid (DHA) is an essential polyunsaturated omega-3 fatty acid, and a fundamental structural component of the phospholipid membranes, especially of neural and retinal cells. DHA is found to be critical for the normal development and functioning of neurons and synaptogenesis in the brain, and is required during pre- and post-natal stages of life. DHA has also been observed to exhibit neuroprotective, cardioprotective, and anti-inflammatory properties. However, geographical dietary variations and poor economic conditions lead to insufficient DHA levels resulting in various health

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Pontifex, Matthew G., Anneloes Martinsen, Rasha N. M. Saleh, et al. "DHA-Enriched Fish Oil Ameliorates Deficits in Cognition Associated with Menopause and the APOE4 Genotype in Rodents." Nutrients 14, no. 9 (2022): 1698. http://dx.doi.org/10.3390/nu14091698.

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Female APOE4 carriers have a greater predisposition to developing Alzheimer’s disease (AD) compared to their male counterparts, which may partly be attributed to menopause. We previously reported that a combination of menopause and APOE4 led to an exacerbation of cognitive and neurological deficits, which were associated with reduced brain DHA and DHA:AA ratio. Here, we explored whether DHA-enriched fish oil (FO) supplementation mitigated the detrimental impact of these risk factors. Whilst DHA-enriched fish oil improved recognition memory (NOR) in APOE4 VCD (4-vinylcyclohexene diepoxide)-trea

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Julianti, Elin, Mochamad Fathurohman, Sophi Damayanti, and Rahmana Emran Kartasasmita. "ISOLATE OF HETEROTROPHIC MICROALGAE AS A POTENTIAL SOURCE FOR DOCOHEXAENOIC ACID (DHA)." Marine Research in Indonesia 43, no. 2 (2018): 79–84. http://dx.doi.org/10.14203/mri.v43i2.264.

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Docosahexaenoic acid (DHA) is one of essential fatty acids that are beneficial to health. Nowadays, the source of docosahexaenoic acid (DHA) is mainly obtained from fish which are extracted into fish oil products. However, the fish oil products still have some drawbacks in term of purity, acceptable flavor for costumers, and also their not environmental friendly production process. As an alternative solution, heterotrophic microalgae can be used as a potential source for DHA due to their excellence compared to fish oil products. The aim of this study is to isolate the heterotropic microalgae t

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Rühl, Ralph, Christin Koch, Tamás Marosvölgyi, et al. "Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution." British Journal of Nutrition 99, no. 6 (2008): 1239–46. http://dx.doi.org/10.1017/s0007114507862374.

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Dietary fatty acids have been shown to influence allergic sensitisation. Both n-3 and n-6 PUFA are involved in targeted mediation of inflammatory responses during allergic sensitisation and manifestation of atopic diseases. In the present experiments we investigated whether supplementation of DHA-enriched fish oil partly substituting dietary sunflower-seed oil, in comparison with sunflower-seed oil, supplemented to mice influences fatty acid composition of serum lipid classes. The effects of the two different diets were also investigated depending on allergic sensitisation. Supplementation of

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Wang, Jun, Jordane Ossemond, Yann Le Gouar, Françoise Boissel, Didier Dupont, and Frédérique Pédrono. "Effect of Docosahexaenoic Acid Encapsulation with Whey Proteins on Rat Growth and Tissue Endocannabinoid Profile." Nutrients 15, no. 21 (2023): 4622. http://dx.doi.org/10.3390/nu15214622.

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Modifying the food structure allows a nutrient to be delivered differently, which can modify not only its digestion process but also its subsequent metabolism. In this study, rats received 3 g of omelette daily containing docosahexaenoic acid (DHA) as crude oil or previously encapsulated with whey proteins, whereas a control group received a DHA-free omelette. The results showed that DHA encapsulation markedly induced a different feeding behaviour so animals ate more and grew faster. Then, after four weeks, endocannabinoids and other N-acyl ethanolamides were quantified in plasma, brain, and h

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Chen, Wenxuan. "Ω-3 PUFA DHA: Benefits Associated With Brain". Transactions on Materials, Biotechnology and Life Sciences 1 (13 листопада 2023): 46–49. http://dx.doi.org/10.62051/z3e6f320.

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DHA and EPA from fish oil are ΩΩ-3 polyunsaturated fatty acids which can’t be synthesized adequately in human body as the conversion from ALA and ARA is low. Thus, we can only get the recommended dose from marine animals and supplements at the natural ratio. Notably, global warming is predicted to decrease availability of this nutrient, and part of its role in the human body cannot be seen in the form of supplements. This review article summarizes the benefits of DHA on fetal development associated with the maternal supplementation. Fish oil can also influence APOE4-associated Alzheimer’s dise

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Ghasemifard, Samaneh, Karen Hermon, Giovanni M. Turchini та Andrew J. Sinclair. "Metabolic fate (absorption, β-oxidation and deposition) of long-chain n-3 fatty acids is affected by sex and by the oil source (krill oil or fish oil) in the rat". British Journal of Nutrition 114, № 5 (2015): 684–92. http://dx.doi.org/10.1017/s0007114515002457.

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The effects of krill oil as an alternative source of n-3 long-chain PUFA have been investigated recently. There are conflicting results from the few available studies comparing fish oil and krill oil. The aim of this study was to compare the bioavailability and metabolic fate (absorption, β-oxidation and tissue deposition) of n-3 fatty acids originating from krill oil (phospholipid-rich) or fish oil (TAG-rich) in rats of both sexes using the whole-body fatty acid balance method. Sprague–Dawley rats (thirty-six male, thirty-six female) were randomly assigned to be fed either a krill oil diet (E

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Rule, Daniel C., Emily A. Melson, Brenda M. Alexander, and Travis E. Brown. "Dietary Fatty Acid Composition Impacts the Fatty Acid Profiles of Different Regions of the Bovine Brain." Animals 12, no. 19 (2022): 2696. http://dx.doi.org/10.3390/ani12192696.

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Fatty acid composition across functional brain regions was determined in bovine brains collected from cattle that were provided supplements of calcium salts containing either palm or fish oil. The Angus cattle were divided into two groups, with one group offered the supplement of calcium salts of palm oil and the other offered the calcium salts of fish oil (n = 5 females and n = 5 males/supplement) for 220 days. These supplements to the basal forage diet were provided ad libitum as a suspension in dried molasses. The fish oil exclusively provided eicosapentaenoic acid (EPA, C20:5 n-3) and doco

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Hingley, Lachlan, Michael J. Macartney, Marc A. Brown, Peter L. McLennan, and Gregory E. Peoples. "DHA-rich Fish Oil Increases the Omega-3 Index and Lowers the Oxygen Cost of Physiologically Stressful Cycling in Trained Individuals." International Journal of Sport Nutrition and Exercise Metabolism 27, no. 4 (2017): 335–43. http://dx.doi.org/10.1123/ijsnem.2016-0150.

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Dietary fish oil, providing docosahexaenoic acid (DHA) modulates oxygen consumption and fatigue in animal models. However, in humans predominately supplemented with high eicosapentaenoic acid (EPA), there is no evidence of endurance performance enhancement. Therefore, this study examined if DHA-rich fish oil could improve repeated bouts of physiologically stressful cycling and a subsequent time trial in a state of fatigue. Twenty-six trained males took part in a double-blind study and were supplemented with either 2 × 1g/day soy oil, Control) or DHA-rich tuna fish oil (Nu-Mega) (FO) (560mg DHA

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