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Journal articles on the topic 'Dheds'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 January 2023

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1

Hammer, Fabian, Sandra Subtil, Philipp Lux, et al. "No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and in Vitro Studies." Journal of Clinical Endocrinology & Metabolism 90, no. 6 (2005): 3600–3605. http://dx.doi.org/10.1210/jc.2004-2386.

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Dehydroepiandrosterone (DHEA) sulfate (DHEAS) is the most abundant steroid in the human circulation and is thought to be the circulating hydrophilic storage form of DHEA. It is generally accepted that DHEA and DHEAS interconvert freely and continuously via hydroxysteroid sulfotransferases and steroid sulfatase and that only desulfated DHEA can be converted downstream to sex steroids. Here we analyzed DHEA/DHEAS interconversion in vivo and in vitro. We administered oral DHEA (100 mg) and iv DHEAS (25 mg) to eight healthy young men, resulting in similar increases in serum DHEAS compared with bas

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2

Prokai-Tatrai, Katalin, and Laszlo Prokai. "CNS-Selective Estrogen Therapy." Proceedings 22, no. 1 (2019): 31. http://dx.doi.org/10.3390/proceedings2019022031.

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17β-Estradiol (E2), the main human estrogen, has been known to exert multiple actions throughout the body, including in the central nervous system (CNS). In particular, it has been shown that E2 is gender-independently needed for brain and eye health. Lack of E2 due to normal aging and/or pathological processes leads to neurological and psychiatric diseases as well as accelerated neurodegeneration. Current estrogen replacement therapies, however, cannot be used as therapeutic interventions to treat these maladies due to a profound, unwanted hormonal exposure to the rest of the body. In this pr

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3

Takeshita, Rafaela S. C., Melissa K. Edler, Richard S. Meindl, Chet C. Sherwood, William D. Hopkins, and Mary Ann Raghanti. "Age, adrenal steroids, and cognitive functioning in captive chimpanzees (Pan troglodytes)." PeerJ 10 (November 9, 2022): e14323. http://dx.doi.org/10.7717/peerj.14323.

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Background Dehydroepiandrosterone-sulfate is the most abundant circulating androgen in humans and other catarrhines. It is involved in several biological functions, such as testosterone production, glucocorticoid antagonist actions, neurogenesis and neuroplasticty. Although the role of dehydroepiandrosterone-sulfate (DHEAS) in cognition remains elusive, the DHEAS/cortisol ratio has been positively associated with a slower cognitive age-decline and improved mood in humans. Whether this relationship is found in nonhuman primates remains unknown. Methods We measured DHEAS and cortisol levels in s

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Nunes-Souza, Emanuelle, Mônica Evelise Silveira, Monalisa Castilho Mendes, et al. "From adrenarche to aging of adrenal zona reticularis: precocious female adrenopause onset." Endocrine Connections 9, no. 12 (2020): 1212–20. http://dx.doi.org/10.1530/ec-20-0416.

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Objective Adaptive changes in DHEA and sulfated-DHEA (DHEAS) production from adrenal zona reticularis (ZR) have been observed in normal and pathological conditions. Here we used three different cohorts to assess timing differences in DHEAS blood level changes and characterize the relationship between early blood DHEAS reduction and cell number changes in women ZR. Materials and methods DHEAS plasma samples (n = 463) were analyzed in 166 healthy prepubertal girls before pubarche (<9 years) and 324 serum samples from 268 adult females (31.9–83.8 years) without conditions affecting steroidogen

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5

Lisnyansky Bar-El, Michal, Su Youn Lee, Ah Young Ki, et al. "Structural Characterization of Full-Length Human Dehydrodolichyl Diphosphate Synthase Using an Integrative Computational and Experimental Approach." Biomolecules 9, no. 11 (2019): 660. http://dx.doi.org/10.3390/biom9110660.

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Dehydrodolichyl diphosphate synthase (DHDDS) is the catalytic subunit of the heteromeric human cis-prenyltransferase complex, synthesizing the glycosyl carrier precursor for N-linked protein glycosylation. Consistent with the important role of N-glycosylation in protein biogenesis, DHDDS mutations result in human diseases. Importantly, DHDDS encompasses a C-terminal region, which does not converge with any known conserved domains. Therefore, despite the clinical importance of DHDDS, our understating of its structure–function relations remains poor. Here, we provide a structural model for the f

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6

Bonser, J., J. Walker, A. Purohit, et al. "Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production." Journal of Endocrinology 167, no. 3 (2000): 465–71. http://dx.doi.org/10.1677/joe.0.1670465.

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Dehydroepiandrosterone sulphate (DHEAS) is the most abundant androgen in the circulation and in ovarian follicular fluid. A steroid sulphatase accepting DHEAS as a substrate has been identified in the follicle, but the cellular location has not been determined. As DHEAS is also a potential source of oestrogen for endocrine-dependent tumours, a potent steroid sulphatase inhibitor oestrone-3-O-sulphamate (EMATE) has been developed which inhibits this activity in rat liver and mammary tumour. The aim of this study was to investigate human granulosa cells as a site of steroid sulphatase activity,

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7

Tóth, Miklós, Károly Rácz, Ibolya Varga, et al. "Plasma dehydroepiandrosterone sulfate levels in patients with hyperfunctioning and non-hyperfunctioning adrenal tumors before and after adrenal surgery." European Journal of Endocrinology 136, no. 3 (1997): 290–95. http://dx.doi.org/10.1530/eje.0.1360290.

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Abstract To investigate the clinical significance of plasma dehydroepiandrosterone sulfate (DHEAS) measurements, 175 patients with histologically confirmed adrenal tumors, 10 cortisol-producing adenomas, 59 aldosterone-producing adenomas, 56 non-hyperfunctioning adenomas, 13 adrenocortical carcinomas, 13 adrenal cysts, and 24 adrenomedullary tumors were studied. Plasma DHEAS levels were expressed as percentage of the mean of sex- and age-matched groups of healthy, normal subjects (DHEAS %). We found that before adrenal surgery, DHEAS % values were significantly reduced in patients with cortiso

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8

Marozkina, Nadzeya, Joe Zein, Mark D. DeBoer, et al. "Dehydroepiandrosterone Supplementation May Benefit Women with Asthma Who Have Low Androgen Levels: A Pilot Study." Pulmonary Therapy 5, no. 2 (2019): 213–20. http://dx.doi.org/10.1007/s41030-019-00101-9.

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ABSTRACT Introduction Among individuals with severe asthma, FEV1 is low in individuals with low dehydroepiandrosterone (DHEA) sulfate (DHEAS) levels. In the Severe Asthma Research Program (SARP), no women with DHEAS > 200 μg/dL had an FEV1 < 60% predicted. DHEA has benefited patients with COPD and pulmonary hypertension in small trials. Therefore, we hypothesized that DHEA supplementation may improve FEV1 in asthmatic women with low DHEAS. Methods Premenopausal, nonsmoking, otherwise healthy women, 18-50 years old, with mild or moderate asthma and baseline FEV1 > 60% predicted receive

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9

Kandathil, A. J., R. Kannangai, S. David, et al. "Human Immunodeficiency Virus Infection and Levels of Dehydroepiandrosterone Sulfate in Plasma among Indians." Clinical Diagnostic Laboratory Immunology 12, no. 9 (2005): 1117–18. http://dx.doi.org/10.1128/cdli.12.9.1117-1118.2005.

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ABSTRACT The shift in cytokine profile during human immunodeficiency virus (HIV) disease progression is influenced by dehydroepiandrosterone sulfate (DHEAS) level. Radioimmunoassay was used to measure plasma DHEAS for 30 treatment-naïve HIV-infected and 30 uninfected individuals. There was a significant negative correlation of viral load with DHEAS level (P < 0.05). Further studies of the use of DHEAS levels for monitoring HIV patients economically are warranted.

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10

Shaimi, Asma Ulhusna, Wan Raihana Wan Aasim, Hasmah Abdullah, Tan Soo Choon, Ang Chee Wei, and Zalina Ismail. "Novel Approaches for Detection Fluorescent-Labeled by Cellvizio Lab System on Hippocampal CA1 Region." Biology, Medicine, & Natural Product Chemistry 8, no. 1 (2019): 1–6. http://dx.doi.org/10.14421/biomedich.2019.81.1-6.

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Neurosteroids have been identified in the 1981. Dehydroepiandrosterone sulphate (DHEAS) is one of the vital neurosteroids that de novo synthesized in the nervous system from cholesterol precursor (Baulieu & Robel, 1998). The aim of the study is to develop a method for fluorescence labelling. Alexa Fluor 488 dye with DHEAS antibody can binds the DHEAS antibody in the rat brain monitored by Cellvizio Lab System. DHEAS antibody (IgG isotype antibodies) was fluorescently conjugated by an amine-reactive compound, Alexa Fluor 5-SDP ester 488 dye. The resultant Alexa Fluor 488-conjugated antibodi

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11

Shukla, Ravindra, Mayank Ganeshani, Monica Agarwal, et al. "Dehydroepiandrostenedione sulphate (DHEAS) levels predict high risk of rheumatoid arthritis (RA) in subclinical hypothyroidism." PLOS ONE 16, no. 2 (2021): e0246195. http://dx.doi.org/10.1371/journal.pone.0246195.

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Introduction The presence of rheumatism is well recognized in primary hypothyroidism. Dehydroepiandrstenedione sulphate (DHEAS) is associated with rheumatological diseases like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study aims to explore relationship between joint pains and DHEAS levels in primary hypothyroidism. Methods Retrospective study of 78 subjects with subclinical hypothyroidism, with TSH within reference range. The joint pains were evaluated by European Union League against rheumatism (EULAR-CSA) score and compared with serum DHEAS, RA factor, Anti-TPO

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12

Gaum, Petra Maria, Viktoria Stefanie Vida, Thomas Schettgen, et al. "Cross-Sectional and Longitudinal Effects of PCB Exposure on Human Stress Hormones in the German HELPcB Surveillance Program." International Journal of Environmental Research and Public Health 17, no. 13 (2020): 4708. http://dx.doi.org/10.3390/ijerph17134708.

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Multiple pathological associations are attributed to PCBs (polychlorinated biphenyls). Research shows a positive association of PCBs with dehydroepiandrosterone sulfate (DHEAS) concentration but the results on the stress hormone cortisol have been inconsistent so far. This study is the first to examine not only the cross-sectional but also the longitudinal effects of PCB exposure on the stress hormones DHEAS and cortisol. Over a period of three years, 112 former employees occupationally exposed to PCBs were tested for their body burden with different types of PCBs (lower and higher chlorinated

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13

Chrisnanda, Rima Hayyu, M. Robiul Fuadi, S. P. Edijanto, and M. Yusuf. "Relationship between Serum Dehydroepiandrosterone Levels and Heart Ejection Fraction in Heart Failure Patients." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 27, no. 2 (2021): 201. http://dx.doi.org/10.24293/ijcpml.v27i2.1664.

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Cardiovascular disease is still a serious problem in the world of health. Life expectancy after being diagnosed with heartfailure is 50% and 10% for 5 and 10 years. Steroid hormones such as Dehydroepiandrosterone (DHEAS) havecardioprotective effects by inhibiting the formation of atherosclerotic plaque, pulmonary artery vasodilators, and protectingcardiomyocytes. DHEAS levels decrease with age. Decreased DHEAS levels are associated with an increased risk ofcardiovascular disease. This study aimed to know the relationship between DHEAS levels in serum and ejection fractions inheart failure pati

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14

Parker, Lawrence. "Control of DHEAS Secretion." Seminars in Reproductive Medicine 13, no. 04 (1995): 275–81. http://dx.doi.org/10.1055/s-2007-1016370.

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15

Goodarzi, Mark O., Enrico Carmina, and Ricardo Azziz. "DHEA, DHEAS and PCOS." Journal of Steroid Biochemistry and Molecular Biology 145 (January 2015): 213–25. http://dx.doi.org/10.1016/j.jsbmb.2014.06.003.

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16

Moriyama, Yasushi, Hirofumi Yasue, Michihiro Yoshimura, et al. "The Plasma Levels of Dehydroepiandrosterone Sulfate Are Decreased in Patients with Chronic Heart Failure in Proportion to the Severity*." Journal of Clinical Endocrinology & Metabolism 85, no. 5 (2000): 1834–40. http://dx.doi.org/10.1210/jcem.85.5.6568.

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Abstract Dehydroepiandrosterone sulfate (DHEAS) is the major secretory steroid of the human adrenal glands. The secretion of DHEAS decreases with aging. The incidence of heart failure also rises in the elderly population. We measured the plasma levels of DHEAS and cortisol in 49 patients with chronic heart failure (CHF) and 32 age-matched controls and assessed its relation to plasma levels of A-type natriuretic peptide and B-type natriuretic peptide, biochemical markers of heart failure. Plasma levels of DHEAS were significantly lower in patients with CHF than in controls, whereas there was no

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Lissoni, P., F. Rovelli, L. Giani, et al. "Dehydroepiandrosterone Sulfate (DHEAS) Secretion in Early and Advanced Solid Neoplasms: Selective Deficiency in Metastatic Disease." International Journal of Biological Markers 13, no. 3 (1998): 154–57. http://dx.doi.org/10.1177/172460089801300306.

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Several endogenous hormones have been proven to stimulate cancer growth, whereas at present very few hormones are known to display oncostatic activity. The most widely investigated antitumor hormone is the pineal indole melatonin (MLT), and cancer progression has been shown to be associated with a decline in MLT secretion. Recently, another hormone, the adrenal steroid dehydroepiandrosterone-sulfate (DHEAS), has appeared to exert antitumor effects similar to those previously described for MLT In addition, experimental studies suggest a diminished DHEAS production with neoplastic progression. T

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18

Wathen, N. C., L. Perry, S. Hodgkinson, and T. Chard. "The relationship between prolactin, dehydroepiandrosterone sulphate and testosterone in normally menstruating females." Acta Endocrinologica 109, no. 2 (1985): 173–75. http://dx.doi.org/10.1530/acta.0.1090173.

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Abstract. Circulating levels of prolactin, dehydroepiandrosterone sulphate (DHEAS) and testosterone (T) were measured in single blood samples from 115 normal women throughout the menstrual cycle. There was an inverse relationship between prolactin and both DHEAS and T. Subjects with high serum prolactin levels had significantly lower levels of DHEAS and T.

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Liu, Meng-si, Yuan Lou, Huan Chen, et al. "Performance of DHEAS as a Screening Test for Autonomous Cortisol Secretion in Adrenal Incidentalomas: A Prospective Study." Journal of Clinical Endocrinology & Metabolism 107, no. 5 (2022): e1789-e1796. http://dx.doi.org/10.1210/clinem/dgac072.

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Abstract Context Autonomous cortisol secretion (ACS) affects up to 30% of patients with adrenal incidentalomas (AIs). The current guidelines for ACS diagnosis are not decisive. A lower dehydroepiandrosterone sulfate (DHEAS) level is a potential biomarker, but the evidence is conflicting. Objective This prospective study aimed to evaluate and validate the ACS screening and diagnostic accuracy of DHEAS. Methods and patients Recruited patients with AI were screened for adrenal medullary and cortisol hypersecretion. The diagnosis of ACS was based on a serum cortisol level ≥ 50 nmol/L following a 1

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20

Terzolo, M., A. Ali, G. Osella, et al. "The value of dehydroepiandrosterone sulfate measurement in the differentiation between benign and malignant adrenal masses." European Journal of Endocrinology 142, no. 6 (2000): 611–17. http://dx.doi.org/10.1530/eje.0.1420611.

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OBJECTIVE: Owing to their increasing rate of discovery as incidental findings, the characterization of adrenal masses is an important diagnostic problem which frequently challenges the clinician's skill. DESIGN: The results of dehydroepiandrosterone sulfate (DHEAS) measurement were evaluated in a consecutive series of 107 patients with an adrenal mass (39 men, 68 women aged 15-81 years, median 56 years). DHEAS levels observed in the patients were categorized as reduced, normal or elevated according to sex- and age-adjusted reference ranges obtained by measuring DHEAS in 214 healthy women and 1

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Kumar, Kislay, Devesh Kumar, Vinay Singh, Pooja T. Pandey, and Divya . "Role of yoga and meditation on serum DHEAS level in first year medical students." International Journal of Research in Medical Sciences 6, no. 6 (2018): 2018. http://dx.doi.org/10.18203/2320-6012.ijrms20182280.

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Background: Dehydroepiandrosterone sulfate (DHEAS), secreted by adrenal cortex, acts in the human body as a neurosteroid, cardio-protective, anti-diabetic, anti-obesity and immune-enhancing agent. It is also reported as a youth hormone. But due to various stimulators of stress, and also as an antagonist of cortisol, DHEAS level decreases. Yoga and meditation regulates the level of hormones and neurotransmitters that affect physiological function.Methods: This study was performed on 1st yr. medical students whose DHEAS level was low due to acute stress. 55 medical students were selected as part

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Goodarzi, Mark O., Heath J. Antoine, and Ricardo Azziz. "Genes for Enzymes Regulating Dehydroepiandrosterone Sulfonation Are Associated with Levels of Dehydroepiandrosterone Sulfate in Polycystic Ovary Syndrome." Journal of Clinical Endocrinology & Metabolism 92, no. 7 (2007): 2659–64. http://dx.doi.org/10.1210/jc.2006-2600.

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Abstract Context: The adrenal androgen (AA) metabolite dehydroepiandrosterone sulfate (DHEAS) is often elevated in women with polycystic ovary syndrome (PCOS); AA excess in PCOS appears to be, in part, a heritable trait. Dehydroepiandrosterone (DHEA) sulfonation is controlled by the enzymes DHEA sulfotransferase (SULT2A1) and steroid sulfatase (STS). Polymorphisms in these genes have not been evaluated as modulators of DHEAS level in PCOS. Objective: The aim was to test the hypothesis that variants in the SULT2A1 and STS genes are associated with DHEAS levels in women with PCOS. Design: Women

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Kim, Jinho, ShinWoo Kang, and Keun-A. Chang. "Effect of cx-DHED on Abnormal Glucose Transporter Expression Induced by AD Pathologies in the 5xFAD Mouse Model." International Journal of Molecular Sciences 23, no. 18 (2022): 10602. http://dx.doi.org/10.3390/ijms231810602.

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Alzheimer’s disease (AD) is a form of dementia associated with abnormal glucose metabolism resulting from amyloid-beta (Aβ) plaques and intracellular neurofibrillary tau protein tangles. In a previous study, we confirmed that carboxy-dehydroevodiamine∙HCl (cx-DHED), a derivative of DHED, was effective at improving cognitive impairment and reducing phosphorylated tau levels and synaptic loss in an AD mouse model. However, the specific mechanism of action of cx-DHED is unclear. In this study, we investigated how the cx-DHED attenuates AD pathologies in the 5xFAD mouse model, focusing particularl

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DeRamus, Marci L., Stephanie J. Davis, Sriganesh Ramachandra Rao, et al. "Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration." Cells 9, no. 3 (2020): 771. http://dx.doi.org/10.3390/cells9030771.

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Patients with certain defects in the dehydrodolichyl diphosphate synthase (DHDDS) gene (RP59; OMIM #613861) exhibit classic symptoms of retinitis pigmentosa, as well as macular changes, suggestive of retinal pigment epithelium (RPE) involvement. The DHDDS enzyme is ubiquitously required for several pathways of protein glycosylation. We wish to understand the basis for selective ocular pathology associated with certain DHDDS mutations and the contribution of specific ocular cell types to the pathology of mutant Dhdds-mediated retinal degeneration. To circumvent embryonic lethality associated wi

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Phillips, Gerald B. "Relationship between serum dehydroepiandrosterone sulfate, androstenedione, and sex hormones in men and women." European Journal of Endocrinology 134, no. 2 (1996): 201–6. http://dx.doi.org/10.1530/eje.0.1340201.

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Phillips GB. Relationship between serum dehydroepiandrosterone sulfate, androstenedione, and sex hormones in men and women. Eur J Endocrinol 1996;134:201–6. ISSN 0804–4643 Previous reports of a correlation between serum dehydroepiandrosterone sulfate (DHEAS) and testosterone in both men and women have led to the suggestion that adrenal and gonadal secretion are related. In the present study, the correlation of DHEAS with testosterone and free testosterone (FT) in both normal men and women was tested. Androstenedione, estradiol, sex hormone binding globulin (SHBG), and insulin were also measure

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Haring, Robin, Henri Wallaschofski, Alexander Teumer, et al. "A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio." Journal of Molecular Endocrinology 50, no. 1 (2012): 73–77. http://dx.doi.org/10.1530/jme-12-0185.

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DHEA is the major precursor of human sex steroid synthesis and is inactivated via sulfonation to DHEAS. A previous genome-wide association study related the single nucleotide polymorphism (SNP) rs2637125, located near the coding region of DHEA sulfotransferase, SULT2A1, to serum DHEAS concentrations. However, the functional relevance of this SNP with regard to DHEA sulfonation is unknown. Using data from 3300 participants of the population-based cohort Study of Health in Pomerania, we identified 43 individuals being homozygote for the minor allele of the SNP rs2637125 (AA) and selected two sex

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Juhász-Vedres, Gabriella, Éva Rózsa, Gabriella Rákos, et al. "Dehydroepiandrosterone Sulfate Is Neuroprotective when Administered Either before or after Injury in a Focal Cortical Cold Lesion Model." Endocrinology 147, no. 2 (2006): 683–86. http://dx.doi.org/10.1210/en.2005-0693.

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Dehydroepiandrosterone and its sulfate (DHEAS) are sex hormone precursors that exert marked neurotrophic and/or neuroprotective activity in the central nervous system. The present study evaluated the effects of DHEAS and 17β-estradiol (E2) in a focal cortical cold lesion model, in which DHEAS (50 mg/kg, sc) and E2 (35 mg/kg, sc) were administered either as pretreatment (two subsequent injections 1 d and 1 h before lesion induction) or posttreatment (immediately after lesion induction). The focal cortical cold lesion was induced in the primary motor cortex by means of a cooled copper cylinder p

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Shaimi, Asma Ulhusna, Hasmah Abdullah, Zalina Ismail, and Wan Amir Nizam Wan Ahmad. "Effect of Dehydroepiandrosterone Sulfate on the Modulation of Memory and Learning in Sprague-Dawley Rat Hippocampus." Proceeding International Conference on Science and Engineering 2 (March 1, 2019): 291–95. http://dx.doi.org/10.14421/icse.v2.105.

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Dehydroepiandrosterone sulphate (DHEAS) is a neurosteroid that is found in greater concentration within the brain rather than in any other body organ (Corpechot et al., 1981) and studies have shown that in the brain, DHEAS has a role in enhancing both learning and memory (Markowski et.al., 2001). This present study investigated the relationship between DHEAS and spatial learning and memory in the rat hippocampus. Male Sprague-Dawley rats were divided into two groups and their spatial learning behaviour was evaluated with the Morris Water Maze. The intensity of DHEAS was simultaneously recorded

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Chen, Rongfang, Xia Peng, Yonghai Song, and Yan Du. "A Paper-Based Electrochemical Sensor Based on PtNP/COFTFPB−DHzDS@rGO for Sensitive Detection of Furazolidone." Biosensors 12, no. 10 (2022): 904. http://dx.doi.org/10.3390/bios12100904.

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Herein, a paper-based electrochemical sensor based on PtNP/COFTFPB−DHzDS@rGO was developed for the sensitive detection of furazolidone. A cluster-like covalent organic framework (COFTFPB−DHzDS) was successfully grown on the surface of amino-functional reduced graphene oxide (rGO-NH2) to avoid serious self-aggregation, which was further loaded with platinum nanoparticles (PtNPs) with high catalytic activity as nanozyme to obtain PtNP/COFTFPB−DHzDS@rGO nanocomposites. The morphology of PtNP/COFTFPB−DHzDS@rGO nanocomposites was characterized, and the results showed that the smooth rGO surface bec

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Salma, Amtul, Sharmada B.K., and Fatima Khalidi. "Dehydroepiandrosterone Sulphate as a Skeletal Maturity Indicator - Cross Sectional Study." International Journal of Health Sciences and Research 12, no. 4 (2022): 301–9. http://dx.doi.org/10.52403/ijhsr.20220435.

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Objective: The aim is to associate dehydroepiandrosterone sulphate (DHEAS) levels to skeletal maturity by using the cervical vertebra stages and its use as skeletal maturity indicator. Results: Mean serum DHEAS levels were significantly higher in the post pubertal stages than in the pre pubertal and early pubertal stages. Linear correlation showed that DHEAS levels had a significant positive correlation with cervical skeletal maturity from the pre pubertal to the post pubertal stages. Conclusion: Serum DHEAS could be used as a reliable indicator of skeletal maturity eliminating the risk of rad

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Chadwick, C. A., L. J. Owen, and B. G. Keevil. "Development of a method for the measurement of dehydroepiandrosterone sulphate by liquid chromatography-tandem mass spectrometry." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 42, no. 6 (2005): 468–74. http://dx.doi.org/10.1258/000456305774538175.

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Background: Dehydroepiandrosterone sulphate (DHEAS) is a steroid that is increasingly being recognized as a potential drug of abuse in many countries. This is due to its reputation as a hormone that may be able to retard the ageing process. The measurement of DHEAS is useful in the diagnosis of medical conditions such as congenital adrenal hyperplasia and polycystic ovary syndrome. Thus, a liquid chromatography-tandem mass spectrometry method has been developed to determine DHEAS concentrations in human serum. Method: The chromatography was performed using a WatersTM 2795 Alliance HT LC system

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Jiménez, Monik C., Katherine L. Tucker, Fátima Rodriguez, Bianca C. Porneala, James B. Meigs, and Lenny López. "Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study." Journal of the Endocrine Society 3, no. 1 (2018): 291–303. http://dx.doi.org/10.1210/js.2018-00205.

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Abstract Low blood dehydroepiandrosterone sulfate (DHEAS) levels have strong positive associations with stroke and coronary heart disease. However, it is unclear whether DHEAS is independently associated with cardiovascular risk factors. Therefore, we examined the association between cardiovascular risk factors and DHEAS concentration among a high-risk population of Latinos (Puerto Ricans aged 45 to 75 years at baseline) in a cross-sectional analysis of the Boston Puerto Rican Health Study. Of eligible participants, 72% completed baseline interviews and provided blood samples. Complete data we

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Sugino, M., N. Ohsawa, T. Ito, et al. "A pilot study of dehydroepiandrosterone sulfate in myotonic dystrophy." Neurology 51, no. 2 (1998): 586–89. http://dx.doi.org/10.1212/wnl.51.2.586.

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We studied the effect of IV administration of a dehydroepiandrosterone sulfate (DHEAS) preparation (200 mg/day for 8 weeks) in 11 patients with myotonic dystrophy (MyD). After DHEAS, activities of daily living improved, muscle strength increased, and myotonia decreased. Conduction block and premature beats also improved in the four patients with cardiac involvement. This pilot study may provide a rationale for a controlled study of DHEAS in MyD.

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Idkowiak, Jan, Yasir S. Elhassan, Pascoe Mannion, et al. "Causes, patterns and severity of androgen excess in 487 consecutively recruited pre- and post-pubertal children." European Journal of Endocrinology 180, no. 3 (2019): 213–21. http://dx.doi.org/10.1530/eje-18-0854.

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Objective Androgen excess in childhood is a common presentation and may signify sinister underlying pathology. Data describing its patterns and severity are scarce, limiting the information available for clinical decision processes. Here, we examined the differential diagnostic value of serum DHEAS, androstenedione (A4) and testosterone in childhood androgen excess. Design Retrospective review of all children undergoing serum androgen measurement at a single center over 5 years. Methods Serum A4 and testosterone were measured by tandem mass spectrometry and DHEAS by immunoassay. Patients with

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Tomi, Masatoshi, Hiromi Eguchi, Mayuko Ozaki та ін. "Role of OAT4 in Uptake of Estriol Precursor 16α-Hydroxydehydroepiandrosterone Sulfate Into Human Placental Syncytiotrophoblasts From Fetus". Endocrinology 156, № 7 (2015): 2704–12. http://dx.doi.org/10.1210/en.2015-1130.

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Estriol biosynthesis in human placenta requires the uptake of a fetal liver-derived estriol precursor, 16α-hydroxydehydroepiandrosterone sulfate (16α-OH DHEAS), by placental syncytiotrophoblasts at their basal plasma membrane (BM), which faces the fetal circulation. The aim of this work is to identify the transporter(s) mediating 16α-OH DHEAS uptake at the fetal side of syncytiotrophoblasts by using human placental BM-enriched vesicles and to examine the contribution of the putative transporter to estriol synthesis at the cellular level, using choriocarcinoma JEG-3 cells. Organic anion transpo

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Goodarzi, Mark O., Ning Xu, and Ricardo Azziz. "Association of CYP3A7*1C and Serum Dehydroepiandrosterone Sulfate Levels in Women with Polycystic Ovary Syndrome." Journal of Clinical Endocrinology & Metabolism 93, no. 7 (2008): 2909–12. http://dx.doi.org/10.1210/jc.2008-0403.

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Abstract Context: Adrenal androgen excess is common in polycystic ovary syndrome (PCOS) and appears to be heritable. CYP3A7 metabolizes dehydroepiandrosterone and its sulfate (DHEAS). A promoter variant, CYP3A7*1C, which results in persistent expression in adults, was associated with reduced DHEAS levels in a previous study, which led us to consider CYP3A7*1C as a modulator of adrenal androgen excess in patients with PCOS. Objective: The objective was to replicate the association between CYP3A7*1C and reduced DHEAS levels in PCOS patients and assess its possible role in modulating testosterone

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de Ronde, Willem, Albert Hofman, Huibert A. P. Pols, and Frank H. de Jong. "A direct approach to the estimation of the origin of oestrogens and androgens in elderly men by comparison with hormone levels in postmenopausal women." European Journal of Endocrinology 152, no. 2 (2005): 261–68. http://dx.doi.org/10.1530/eje.1.01830.

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Objective: The origin of oestrogens in men is only partly understood. From infusion studies with radioactively labelled hormones, we know that oestradiol (E2) and oestrone (E1) are either directly secreted by the testes and adrenal glands or peripherally produced from testicular or adrenal androgens. Design and methods: We determined E2, E1, androstenedione, testosterone and dehydroepiandroster-one sulphate (DHEAS) in 292 elderly men and 367 postmenopausal women. We considered post-menopausal women as men without testes, assuming that the postmenopausal ovary is not endocrinologically active a

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Fliesler, Steven J., Sriganesh Ramachandra Rao, Mai N. Nguyen, Mahmoud Tawfik KhalafAllah, and Steven J. Pittler. "Vertebrate Animal Models of RP59: Current Status and Future Prospects." International Journal of Molecular Sciences 23, no. 21 (2022): 13324. http://dx.doi.org/10.3390/ijms232113324.

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Retinitis pigmentosa-59 (RP59) is a rare, recessive form of RP, caused by mutations in the gene encoding DHDDS (dehydrodolichyl diphosphate synthase). DHDDS forms a heterotetrameric complex with Nogo-B receptor (NgBR; gene NUS1) to form a cis-prenyltransferase (CPT) enzyme complex, which is required for the synthesis of dolichol, which in turn is required for protein N-glycosylation as well as other glycosylation reactions in eukaryotic cells. Herein, we review the published phenotypic characteristics of RP59 models extant, with an emphasis on their ocular phenotypes, based primarily upon knoc

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Quester, Johan, Maria Nethander, Anna Eriksson, and Claes Ohlsson. "Endogenous DHEAS Is Causally Linked With Lumbar Spine Bone Mineral Density and Forearm Fractures in Women." Journal of Clinical Endocrinology & Metabolism 107, no. 5 (2021): e2080-e2086. http://dx.doi.org/10.1210/clinem/dgab915.

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Abstract Context A recent pooled analysis of four clinical trials demonstrated that treatment with dehydroepiandrosterone (DHEA) increases lumbar spine bone mineral density (LS-BMD) in women. The causal effect of endogenous adrenal-derived DHEA sulphate (DHEAS) on LS-BMD and fracture risk in women is unknown. Objective To determine whether circulating DHEAS is causally associated with LS-BMD and fracture risk in women. Methods A 2-sample Mendelian randomization study using genetic predictors of serum DHEAS derived from the largest available female-specific genome wide association study (GWAS)

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Kulle, Alexandra E., Thomas Reinehr, Gunter Simic-Schleicher, Nadine C. Hornig та Paul-Martin Holterhus. "Determination of 17OHPreg and DHEAS by LC-MS/MS: Impact of Age, Sex, Pubertal Stage, and BMI on the Δ5 Steroid Pathway". Journal of Clinical Endocrinology & Metabolism 102, № 1 (2016): 232–41. http://dx.doi.org/10.1210/jc.2016-2849.

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Abstract Background: Dehydroepiandrosterone sulfate (DHEAS) and 17-hydroxypregnenolone (17OHPreg) are important for understanding the Δ5 pathway (e.g., in adrenarche and obesity). Although mass spectrometry has become the state-of-the-art method for quantifying steroids, there are few comprehensive age-, sex-, and pubertal stage–specific reference ranges for children. Aims: To develop a sensitive and reliable ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for simultaneous quantification of DHEAS and 17OHPreg and to establish entire age-, sex- and pubertal

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Rege, Juilee, Aya T. Nanba, Richard J. Auchus, et al. "Adrenocorticotropin Acutely Regulates Pregnenolone Sulfate Production by the Human Adrenal In Vivo and In Vitro." Journal of Clinical Endocrinology & Metabolism 103, no. 1 (2017): 320–27. http://dx.doi.org/10.1210/jc.2017-01525.

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Abstract Background Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in human circulation, and adrenocorticotropic hormone (ACTH) is considered the major regulator of its synthesis. Pregnenolone sulfate (PregS) and 5-androstenediol-3-sulfate (AdiolS) have recently emerged as biomarkers of adrenal disorders. Objective To define the relative human adrenal production of Δ5-steroid sulfates under basal and cosyntropin-stimulated conditions. Methods Liquid chromatography-tandem mass spectrometry was used to quantify three unconjugated and four sulfated Δ5-steroids in (1) paired a

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Suresh, Malavika, Lucinda Gruber, and Irina Bancos. "The Diagnostic Accuracy of Dehydroepiandrosterone Sulfate in Diagnosing Adrenal Insufficiency." Journal of the Endocrine Society 5, Supplement_1 (2021): A97—A98. http://dx.doi.org/10.1210/jendso/bvab048.195.

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Abstract Background: Evaluation for adrenal insufficiency (AI) includes dynamic testing that is cumbersome, expensive, and may not always be accessible. Our objective was to evaluate the diagnostic accuracy of dehydroepiandrosterone sulfate (DHEAS) in diagnosing AI. Methods: This is a single-center retrospective study of patients evaluated for AI between July 10th, 2012 to January 7th, 2020 who underwent Cosyntropin stimulation testing (CST) or Insulin tolerance test (ITT), and had baseline measurement of DHEAS. Diagnosis of adrenal insufficiency was based on peak cortisol of &lt;18 ug/dL

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Logaprabhu, Nandhini, and Sarmishta Murugesan. "Comparison of Clinical and Biochemical Markers of Hirsutism in Polycystic Ovary Syndrome – A Study from a Teaching Hospital in Sri Ramachandra Institute, Chennai, India." Journal of Evolution of Medical and Dental Sciences 10, no. 16 (2021): 1140–44. http://dx.doi.org/10.14260/jemds/2021/243.

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BACKGROUND We wanted to analyse the clinical profile of polycystic ovarian syndrome (PCOS) women with history, examination and ultrasonogram and correlate hirsutism with biochemical markers as free testosterone, dehydro-epiandrosterone sulphate (DHEAS), sex hormone binding globulin (SHBG), free testosterone, DHEAS, and SHBG. METHODS This study is a prospective observational study conducted from 2011 to 2013 in the Department of Obstetrics and Gynaecology, Shree Balaji Medical College and Hospital, Chrompet in patients attending Gynaecology OPD. 100 women visiting the OPD were taken as control

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Hanukoglu, Aaron, Daniel Fried, Ishak Nakash, and Israel Hanukoglu. "Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants." European Journal of Endocrinology 133, no. 5 (1995): 552–56. http://dx.doi.org/10.1530/eje.0.1330552.

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Hanukoglu A, Fried D, Nakash I, Hanukoglu I. Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants. Eur J Endocrinol 1995;133:552–6. ISSN 0804–4643 To examine steroidogenic responses of the different zones of the adrenal cortex to acute disease we determined the basal and adrenocorticotropin (ACTH)-stimulated levels of cortisol, dehydroepian-drosterone (DHEAS) and aldosterone in 16 infants aged 1–4 months with acute bronchiolities, Fourteen of the infants were retested after recovery. During illness the mean basal levels of cortisol and DHEAS were tw

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Nyce, Jonathan W. "Detection of a novel, primate-specific ‘kill switch’ tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53." Endocrine-Related Cancer 25, no. 11 (2018): R497—R517. http://dx.doi.org/10.1530/erc-18-0241.

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The activation of TP53 is well known to exert tumor suppressive effects. We have detected aprimate-specificadrenal androgen-mediated tumor suppression system in which circulating DHEAS is converted to DHEA specifically in cells in which TP53 has beeninactivated. DHEA is anuncompetitiveinhibitor of glucose-6-phosphate dehydrogenase (G6PD), an enzyme indispensable for maintaining reactive oxygen species within limits survivable by the cell. Uncompetitive inhibition is otherwise unknown in natural systems because it becomesirreversiblein the presence of high concentrations of substrate and inhibi

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Weill-Engerer, Sébastien, Jean-Philippe David, Véronique Sazdovitch, et al. "Neurosteroid Quantification in Human Brain Regions: Comparison between Alzheimer’s and Nondemented Patients." Journal of Clinical Endocrinology & Metabolism 87, no. 11 (2002): 5138–43. http://dx.doi.org/10.1210/jc.2002-020878.

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Abstract Some neurosteroids have been shown to display beneficial effects on neuroprotection in rodents. To investigate the physiopathological significance of neurosteroids in Alzheimer’s disease (AD), we compared the concentrations of pregnenolone, pregnenolone sulfate (PREGS), dehydroepiandrosterone, dehydroepiandrosterone sulfate (DHEAS), progesterone, and allopregnanolone, measured by gas chromatography-mass spectrometry, in individual brain regions of AD patients and aged nondemented controls, including hippocampus, amygdala, frontal cortex, striatum, hypothalamus, and cerebellum. A gener

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Aleynov, Viacheslav A., Elena M. Frantsiyants, Valeria A. Bandovkina, et al. "Blood levels of steroid hormone precursors allow differentiation between pancreatic adenocarcinoma and neuroendocrine tumors." Journal of Clinical Oncology 38, no. 15_suppl (2020): e16692-e16692. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16692.

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e16692 Background: The activity of some enzymes involved in the synthesis and transformation of sex hormones changes in some tumor tissues of the pancreas, which can affect the circulating concentrations of these hormones in the blood. The purpose of the study was to determine the possibility of differential diagnosis of pancreatic cancer at primary examination. Methods: Levels of 17OHP and DHEAS were measured by RIA in the blood of 25 men with chronic pancreatitis (CP), 34 patients with pancreatic adenocarcinoma (PA) and 15 patients with pancreatic neuroendocrine tumors (PNET). The results we

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Blaney, Barry, Sukumar Chakraborty, and Sally-Ann Murray. "Alkaloid production by isolates of the sorghum ergot pathogen (Claviceps africana) from Australia and other countries." Australian Journal of Agricultural Research 57, no. 9 (2006): 1023. http://dx.doi.org/10.1071/ar05334.

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Isolates of Claviceps africana from Australia, Africa, Asia, and America were tested for the production of dihydroergosine (DHES), and its biogenic precursors dihydroelymoclavine (DHEL) and festuclavine (FEST), in culture. Several growth media were evaluated to optimise alkaloid production with little success. The best of these involved 2-stage culturing on high-sucrose substrate. Australian C. africana isolates varied widely and inconsistently in alkaloid production, with DHES concentrations in mycelium ranging from: <0.1 to 9 mg DHES/kg; <0.1 to 1.6 mg DHEL/kg; and <0.1 to 0.4 mg FE

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Jug, Juraj, and Martina Matovinović. "Dehydroepiandrosterone Sulfate and Arterial Hypertension." Southeastern European medical journal 6, no. 1 (2022): 68–73. http://dx.doi.org/10.26332/seemedj.v6i1.228.

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Dehydroepiandrosterone sulfate (DHEAS) is a steroid molecule whose function and mechanism of action in the human body are still inadequately researched. A potential protective function for the cardiovascular system can be explained by activation of nitric oxide production, impact on endothelial and mitochondrial function, and inhibition of proinflammatory cytokine production (IL-6 and TNF-α). Some research shows the beneficial effects of DHEA/DHEAS on many bodily functions, especially in the cardiovascular and the neurological systems. However, we need to be careful with interpretation of the

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George-Opuda, I. M., A. O. Adegoke, O. E. Bamigbowu, and C. Nwaganga. "Comparative Investigation on the Concentrations of Dehydroepiandrosterone (DHEA) and Testosterone Levels in Infertile Males attending a Private University Teaching Hospital, in Rivers State, Nigeria." Journal of Applied Sciences and Environmental Management 25, no. 8 (2021): 1465–69. http://dx.doi.org/10.4314/jasem.v25i8.28.

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The study was carried out to determine the concentrations of Dehydroepiandrosterone hormone (DHEAS) and testosterone in infertile males and compared with fertile males attending Madonna University Teaching Hospital (MUTH) Elele. Thirty apparently infertile males and 30 apparently fertile male as control had their Dehydroepiandrosterone hormone (DHEAS) and testosterone determined using competitive immune enzymatic colorimetric method and Enzyme Immunoassay while the semen analysis was done using Microscopy method. There was significant increase (P<0.05) in DHEAS of 1.23+0.07 ug/ml obtained i

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