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Journal articles on the topic 'DHEQ'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Boiko, Olga V., Sarah R. Baker, Barry J. Gibson, et al. "Construction and validation of the quality of life measure for dentine hypersensitivity (DHEQ)." Journal of Clinical Periodontology 37, no. 11 (2010): 973–80. http://dx.doi.org/10.1111/j.1600-051x.2010.01618.x.

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He, Song-lin, and Jin-hua Wang. "Reliability and validity of the Chinese version of the short form of the Dentine Hypersensitivity Experience Questionnaire (DHEQ-15)." Quality of Life Research 24, no. 6 (2014): 1465–69. http://dx.doi.org/10.1007/s11136-014-0856-8.

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Blaney, Barry, Sukumar Chakraborty, and Sally-Ann Murray. "Alkaloid production by isolates of the sorghum ergot pathogen (Claviceps africana) from Australia and other countries." Australian Journal of Agricultural Research 57, no. 9 (2006): 1023. http://dx.doi.org/10.1071/ar05334.

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Isolates of Claviceps africana from Australia, Africa, Asia, and America were tested for the production of dihydroergosine (DHES), and its biogenic precursors dihydroelymoclavine (DHEL) and festuclavine (FEST), in culture. Several growth media were evaluated to optimise alkaloid production with little success. The best of these involved 2-stage culturing on high-sucrose substrate. Australian C. africana isolates varied widely and inconsistently in alkaloid production, with DHES concentrations in mycelium ranging from: <0.1 to 9 mg DHES/kg; <0.1 to 1.6 mg DHEL/kg; and <0.1 to 0.4 mg FE

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Petrucci, O., and M. Polemio. "The use of historical data for the characterisation of multiple damaging hydrogeological events." Natural Hazards and Earth System Sciences 3, no. 1/2 (2003): 17–30. http://dx.doi.org/10.5194/nhess-3-17-2003.

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Abstract. Landslides, floods and secondary floods (hereinafter called phenomena) triggered by rainfall and causing extensive damage are reviewed in this paper. Damaging Hydrogeological Events (DHEs) are defined as the occurrence of one or more simultaneous aforementioned phenomena. A method for the characterisation of DHEs based upon historic data is proposed. The method is aimed at assessing DHE-related hazard in terms of recurrence, severity, damage, and extent of the affected area. Using GIS, the DHEs historical and climatic data collection, the geomorphological and hydrogeological characte

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Aceto, L., and O. Petrucci. "Identification of rainfall triggering damaging hydrogeological events: a methodological approach applied to Calabria (Italy)." Proceedings of the International Association of Hydrological Sciences 364 (September 16, 2014): 153–58. http://dx.doi.org/10.5194/piahs-364-153-2014.

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Abstract. The paper deals with Damaging Hydrogeological Events (DHEs), defined as periods of severe weather affecting wide regions for several days, and during which landslides and floods cause economic damage and there are victims. The great variability of DHEs in both space and time is the cause of one of the main problems to solve in performing analyses of these events. Dealing with events affecting wide areas for several days, it is problematic to isolate the rainy days that can be considered as factors triggering the observed damaging phenomena. We develop a methodological approach aiming

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Kupferschmid, Barbara J., and Barbara A. Therrien. "Spatial Learning Responses to Lipopolysaccharide in Adult and Aged Rats." Biological Research For Nursing 20, no. 1 (2017): 32–39. http://dx.doi.org/10.1177/1099800417726875.

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Sickness behaviors, adaptive responses to infections, include lethargy, depression, reduced eating and grooming, and concentration problems resulting from interactions between the immune and neuroendocrine systems. Detecting these responses is especially critical in the elderly, as the infections that cause them can lead to cognitive impairment. While deficits in spatial learning, a hippocampal-dependent form of learning, are part of the sickness response, directional heading errors (DHEs; an indicator of spatial-learning deficits) and their time trajectories need further examination. Therefor

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7

&NA;. "DHEA." Inpharma Weekly &NA;, no. 1147 (1998): 2. http://dx.doi.org/10.2165/00128413-199811470-00002.

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8

Khorram, Omid. "DHEA." Current Opinion in Obstetrics and Gynecology 8, no. 5 (1996): 351–54. http://dx.doi.org/10.1097/00001703-199610000-00006.

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9

Guéchot, Jérôme. "Déhydroépiandrostérone (DHEA) et sulfate de DHEA." EMC - Biologie Médicale 1, no. 1 (2006): 1–3. http://dx.doi.org/10.1016/s2211-9698(06)76057-5.

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10

Kroboth, Patricia D., Firoozeh S. Salek, Amy L. Pittenger, Tanya J. Fabian, and Reginald F. Frye. "DHEA and DHEA-S: A Review." Journal of Clinical Pharmacology 39, no. 4 (1999): 327–48. http://dx.doi.org/10.1177/00912709922007903.

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11

Marinelli, Lieta, Erminio Trevisi, Laura Da Dalt, Mariacristina Merlo, Giuseppe Bertoni, and Gianfranco Gabai. "Dehydroepiandrosterone secretion in dairy cattle is episodic and unaffected by ACTH stimulation." Journal of Endocrinology 194, no. 3 (2007): 627–35. http://dx.doi.org/10.1677/joe-07-0226.

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This paper describes the episodic release and response to adrenal stimulation of cortisol and dehydroepiandrosterone (DHEA) in cows. Observations made in samples taken every 10 min for 8 h (experiment 1) showed that plasma DHEA was significantly greater (P < 0.001) than DHEA-S, and release of these steroids was episodic and variable between animals (P < 0.01). No relationship was found between DHEA and cortisol. Significant (P < 0.001) DHEA-sulphate (DHEA-S) versus cortisol (R = −0.264) and DHEA-S versus DHEA (R = 0.200) correlations were found. DHEA and DHEA-S were not affected by a

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12

Baulieu, EE. "Neuroactive neurosteroids: dehydroepiandrosterone (DHEA) and DHEA sulphate." Acta Paediatrica 88, s433 (1999): 78–80. http://dx.doi.org/10.1111/j.1651-2227.1999.tb14408.x.

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13

Liu, Pei Feng, Hong Zhi Wang, Jun Zhang, Hui Yu, Yao Gang Li, and You Rong Duan. "Effects of Exercise on Antitumor Efficacy of DHAQ-Loaded PLA-PLL-RGD Nanoparticles in Hepatocellular Carcinoma." Materials Science Forum 610-613 (January 2009): 1244–47. http://dx.doi.org/10.4028/www.scientific.net/msf.610-613.1244.

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This study mainly describes the synthesis of Arginine-Glycine-Aspartic (RGD) peptide modification of copolymer: poly(lactic acid-co-L-lysine) (PLA-PLL- RGD) and preparation of mitoxantrone(DHAQ)-loaded PLA-PLL-RGD nanoparticles (DHAQ-NP), and researches the effects of exercise on antitumor efficacy of DHAQ-NP in hepatocellular carcinoma. Experimental results show that compared with DHAQ-only group, the DHAQ concentration of tumor in Exercise+DHAQ-NP and DHAQ-NP groups up-regulate significantly. Tumor volume and weight of mice were significantly decreased in the DHAQ-NP and Exercise+DHAQ-NP gro

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14

Hammer, Fabian, Sandra Subtil, Philipp Lux, et al. "No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and in Vitro Studies." Journal of Clinical Endocrinology & Metabolism 90, no. 6 (2005): 3600–3605. http://dx.doi.org/10.1210/jc.2004-2386.

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Dehydroepiandrosterone (DHEA) sulfate (DHEAS) is the most abundant steroid in the human circulation and is thought to be the circulating hydrophilic storage form of DHEA. It is generally accepted that DHEA and DHEAS interconvert freely and continuously via hydroxysteroid sulfotransferases and steroid sulfatase and that only desulfated DHEA can be converted downstream to sex steroids. Here we analyzed DHEA/DHEAS interconversion in vivo and in vitro. We administered oral DHEA (100 mg) and iv DHEAS (25 mg) to eight healthy young men, resulting in similar increases in serum DHEAS compared with bas

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15

Tagawa, Noriko, Junko Tamanaka, Aya Fujinami, et al. "Serum Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate, and Pregnenolone Sulfate Concentrations in Patients with Hyperthyroidism and Hypothyroidism." Clinical Chemistry 46, no. 4 (2000): 523–28. http://dx.doi.org/10.1093/clinchem/46.4.523.

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Abstract Background: Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to have protective effects against cardiovascular disease, cancer, immune-modulated diseases, and aging. We examined serum concentrations of DHEA, DHEA-S, and pregnenolone sulfate (PREG-S) in patients with thyroid dysfunction. Methods: Steroids extracted with methanol from serum sample were separated into an unconjugated fraction (DHEA) and a monosulfate fraction (DHEA-S and PREG-S), using a solid-phase extraction and an ion-exchange column. After separation of unconjugated steroi

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16

Yamauchi, Akira, Izumi Takei, Akira Kasuga, et al. "Depression of dehydroepiandrosterone in Japanese diabetic men—comparison between non-insulin-dependent diabetes mellitus and impaired glucose tolerance." European Journal of Endocrinology 135, no. 1 (1996): 101–4. http://dx.doi.org/10.1530/eje.0.1350101.

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Yamauchi A, Takei I, Kasuga A, Kitamura Y, Ohashi N, Nakano S, Takayama S, Nakamoto S, Katsukawa F, Saruta T. Depression of dehydroepiandrosterone in Japanese diabetic men—comparison between non-insulin-dependent diabetes mellitus and impaired glucose tolerance. Eur J Endocrinol 1996;135:101–4. ISSN 0804–4643 Hyperglycemia is known to reduce dehydroepiandrosterone (DHEA) circulating levels; however, the mechanism by which hyperglycemia decreases DHEA is not elucidated. In this study, serum DHEA and DHEA sulfate (DHEA-S) levels were compared in 50 men with non-insulin-dependent diabetes mellitu

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17

BERDANIER, CAROLYN D. "Dehydroepiandrosterone (DHEA)." Nutrition Today 28, no. 6 (1993): 34–37. http://dx.doi.org/10.1097/00017285-199311000-00007.

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18

Pepping, Joseph. "DHEA: Dehydroepiandrosterone." American Journal of Health-System Pharmacy 57, no. 22 (2000): 2048–56. http://dx.doi.org/10.1093/ajhp/57.22.2048.

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19

Cui, Ya-Jun, Shu-Hong Guan, Li-Xing Feng, et al. "Cytotoxicity of 9,11-Dehydroergosterol Peroxide Isolated from Ganoderma Lucidum and its Target-related Proteins." Natural Product Communications 5, no. 8 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500806.

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The cytotoxicty of 9,11-dehydroergosterol peroxide (DHEP) isolated from the fruiting bodies of Ganoderma lucidum on HeLa cells was studied. DHEP treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with an IC50-value of 8.58 ± 0.98 μM. Morphological changes of DHEP-treated cells indicated that DHEP induced apoptosis in HeLa cells. To identify the cellular targets of DHEP, two-dimensional electrophoresis analysis was performed to compare the protein expression profiles of DHEP-treated cells with that of control cells. Proteins altered in expressional level after

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20

Nonnenmacher, L. "Informations réactifs : DHEA, DHEA-sulfate, 17α-OH progestérone". Immuno-analyse & Biologie Spécialisée 17, № 5 (2002): 348–55. http://dx.doi.org/10.1016/s0923-2532(02)01222-x.

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21

Waschatko, Gustav, Elzbieta Kojro, Michael Zahnow, and Katja Gehrig-Burger. "Photo-DHEA—A functional photoreactive dehydroepiandrosterone (DHEA) analog." Steroids 76, no. 5 (2011): 502–7. http://dx.doi.org/10.1016/j.steroids.2011.01.009.

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22

Hinson, JP, and PW Raven. "DHEA deficiency syndrome: a new term for old age?" Journal of Endocrinology 163, no. 1 (1999): 1–5. http://dx.doi.org/10.1677/joe.0.1630001.

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Dehydroepiandrosterone (DHEA) is a steroid secreted by the adrenal cortex, with a characteristic, age-related, pattern of secretion. The decline of DHEA concentrations with age has led to the suggestion that old age represents a DHEA deficiency syndrome and that the effects of ageing can be counteracted by DHEA 'replacement therapy'. DHEA is increasingly being used in the USA, outside medical supervision, for its supposed anti-ageing effects. This commentary weighs the evidence for the existence of a DHEA deficiency syndrome and considers the value of DHEA 'replacement therapy'.

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23

Arlt, Wiebke, Joachim Haas, Frank Callies, et al. "Biotransformation of Oral Dehydroepiandrosterone in Elderly Men: Significant Increase in Circulating Estrogens." Journal of Clinical Endocrinology & Metabolism 84, no. 6 (1999): 2170–76. http://dx.doi.org/10.1210/jcem.84.6.5789.

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The most abundant human steroids, dehydroepiandrosterone (DHEA) and its sulfate ester DHEAS, may have a multitude of beneficial effects, but decline with age. DHEA possibly prevents immunosenescence, and as a neuroactive steroid it may influence processes of cognition and memory. Epidemiological studies revealed an inverse correlation between DHEAS levels and the incidence of cardiovascular disease in men, but not in women. To define a suitable dose for DHEA substitution in elderly men we studied pharmacokinetics and biotransformation of orally administered DHEA in 14 healthy male volunteers (

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24

Schindler, Lena, Mohammed Shaheen, Rotem Saar-Ashkenazy, et al. "Victims of War: Dehydroepiandrosterone Concentrations in Hair and Their Associations with Trauma Sequelae in Palestinian Adolescents Living in the West Bank." Brain Sciences 9, no. 2 (2019): 20. http://dx.doi.org/10.3390/brainsci9020020.

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Due to its anti-glucocorticoid properties, the steroid hormone dehydroepiandrosterone (DHEA) might play a role for coping with traumatic stress and posttraumatic stress disorder (PTSD). The majority of studies report elevated DHEA secretion and decreased cortisol/DHEA ratio associated with traumatic stress, however, contrasting results have also been published. One reason for this heterogeneity might be that in past studies, DHEA has been measured in plasma or saliva samples reflecting acute hormone levels. In comparison, the current study assessed the hair levels of DHEA and cortisol as long-

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Swinkels, L. M., H. A. Ross, A. G. Smals, and T. J. Benraad. "Concentrations of total and free dehydroepiandrosterone in plasma and dehydroepiandrosterone in saliva of normal and hirsute women under basal conditions and during administration of dexamethasone/synthetic corticotropin." Clinical Chemistry 36, no. 12 (1990): 2042–46. http://dx.doi.org/10.1093/clinchem/36.12.2042.

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Abstract Using a specific and sensitive radioimmunoassay involving extraction with diethyl ether and chromatographic separation of steroids, we measured concentrations of salivary and plasma dehydroepiandrosterone (DHEA) in 22 women with normal ovulatory cycles (ages 18-45 years). Salivary DHEA values closely correlated with total and free DHEA in plasma. In the follicular phase the mean concentrations of salivary and plasma free DHEA were virtually equal [mean (SD): 0.61 (0.32) and 0.56 (0.34) nmol/L, respectively]. In the luteal phase, salivary DHEA slightly exceeded the plasma free DHEA [0.

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McNelis, Joanne C., Konstantinos N. Manolopoulos, Laura L. Gathercole, et al. "Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake." American Journal of Physiology-Endocrinology and Metabolism 305, no. 9 (2013): E1134—E1144. http://dx.doi.org/10.1152/ajpendo.00314.2012.

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Glucocorticoids increase adipocyte proliferation and differentiation, a process underpinned by the local reactivation of inactive cortisone to active cortisol within adipocytes catalyzed by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The adrenal sex steroid precursor dehydroepiandrosterone (DHEA) has been shown to inhibit 11β-HSD1 in murine adipocytes; however, rodent adrenals do not produce DHEA physiologically. Here, we aimed to determine the effects and underlying mechanisms of the potential antiglucocorticoid action of DHEA and its sulfate ester DHEAS in human preadipocytes. Utiliz

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Jia, Xiaoming, Caroline Sun, Olive Tang, et al. "Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women." Journal of Clinical Endocrinology & Metabolism 105, no. 12 (2020): e4304-e4327. http://dx.doi.org/10.1210/clinem/dgaa518.

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Abstract Context Lower dehydroepiandrosterone-sulfate (DHEA-S) levels have been inconsistently associated with coronary heart disease (CHD) and mortality. Data are limited for heart failure (HF) and association between DHEA-S change and events. Objective Assess associations between low DHEA-S/DHEA-S change and incident HF hospitalization, CHD, and mortality in older adults. Design DHEA-S was measured in stored plasma from visits 4 (1996-1998) and 5 (2011-2013) of the Atherosclerosis Risk in Communities study. Follow-up for incident events: 18 years for DHEA-S level; 5.5 years for DHEA-S change

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Taylor-Cavelier, Sarah J., Valerie J. Micol, Andrea G. Roberts, Elisa G. Geiss, and Nestor Lopez-Duran. "DHEA Moderates the Impact of Childhood Trauma on the HPA Axis in Adolescence." Neuropsychobiology 80, no. 4 (2021): 299–312. http://dx.doi.org/10.1159/000511629.

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<b><i>Background:</i></b> Trauma can lead to long-term downregulation of the hypothalamic pituitary adrenal (HPA) axis. However, dehydroepiandrosterone (DHEA) has neuroprotective effects that may reduce the need for downregulation of the axis in response to stress. Furthermore, high DHEA/cortisol ratios are often conceptualized as better markers of DHEA’s availability than DHEA alone, as ratios account for the coupling of DHEA and cortisol in response to stress. <b><i>Objectives:</i></b> In this study, we explored if DHEA and DHEA/cortisol ratios

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Sun, Hong-Zhi, Tong-Wei Yang, Wei-Jin Zang, and Shu-Fang Wu. "Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated by NFKB via PI3K/AKT signaling pathway." Journal of Endocrinology 204, no. 3 (2009): 311–18. http://dx.doi.org/10.1677/joe-09-0270.

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Dehydroepiandrosterone (DHEA) is an endogenous steroid that is metabolized to androgens and/or estrogens in the human prostate. DHEA levels decline with age, and use of DHEA supplements to retard the aging process is of unproved effectiveness and safety. In this study, rat ventral prostatic epithelial cells were used to determine whether DHEA-modulated proliferation and prostate-specific antigen (PSA listed as KLKB1 in the MGI Database) production were mediated via the androgen receptor (AR) and its potential mechanism. We demonstrated that proliferation of prostatic epithelial cells and incre

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Mostafa, Sahar I., Spyros P. Perlepes та Nick Hadjiliadis. "New Dinuclear Transition Metal Complexes with the [M2(μ-dhbq)]n+ Core and 2-(2′-Pyridyl)quinoxaline (L) as a Terminal Ligand: Preparation and Characterization (dhbq2-= the Dianion of 2,5-Dihydroxy -1,4- benzoquinone; M = AgI, MnII, CoII, NiII, CuII, RuII, PdII, FeIII, RhIII; n = 0, 2, 4)". Zeitschrift für Naturforschung B 56, № 4-5 (2001): 394–402. http://dx.doi.org/10.1515/znb-2001-4-512.

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Abstract Synthetic procedures are described that allow access to the new complexes [Mn2(dhbq)L2(H2O)4 (1), [Fe2(dhbq)L2(H2O)4](NO3)4 · 6H2O (2), [Co2(dhbq)Cl2L2(H2O)2] (3), [Ni2(dhbq)Cl2L2(H2O)2] (4), [Cu2(dhbq)Cl2L2(H2O)2] (5), [Ru2(dhbq)L2(H2O)4](ClO4)2 (6), [Rh2(dhbq)Cl2L2(H2O)2]Cl2·2H2O (7), [Pd2(dhbq)L2]Cl2·5H2O (8) and [Ag2(dhbq)L2] (9), where dhbq2- is the dianion of 2,5-dihydroxy-1,4-benzoquinone and L is the biheteroaromatic ligand 2-(2′-pyridyl)quinoxaline. The new complexes were characterized by elemental analyses and by a variety of physical and spectroscopic techniques. Dinuclear

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Catalina, Fernando, Leon Milewich, William Frawley, Vinay Kumar, and Michael Bennett. "Decrease of Core Body Temperature in Mice by Dehydroepiandrosterone." Experimental Biology and Medicine 227, no. 6 (2002): 382–88. http://dx.doi.org/10.1177/153537020222700603.

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Dietary dehydroepiandrosterone (DHEA) reduces food intake in mice, and this response is under genetic control. Moreover, both food restriction and DHEA can prevent or ameliorate certain diseases and mediate other biological effects. Mice fed DHEA (0.45% w/w of food) and mice pair-fed to these mice (food restricted) for 8 weeks were tested for changes in body temperature. DHEA was more efficient than food restriction alone in causing hypothermia. DHEA injected intraperitoneally also induced hypothermia that reached a nadir at 1 to 2 hr, and slowly recovered by 20 to 24 hr. This effect was dose

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Danenberg, H. D., A. Ben-Yehuda, Z. Zakay-Rones, D. J. Gross, and G. Friedman. "Dehydroepiandrosterone Treatment Is Not Beneficial to the Immune Response to Influenza in Elderly Subjects*." Journal of Clinical Endocrinology & Metabolism 82, no. 9 (1997): 2911–14. http://dx.doi.org/10.1210/jcem.82.9.4256.

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Abstract Background. Dehydroepiandrosterone (DHEA) is a native steroid with an immunomodulating activity that was suggested to counterregulate some phenomena of immunosenescence. Recently, it was shown to reverse the age-associated decline of immune response against influenza vaccine in aged mice. The present study was designed to evaluate the effect of DHEA on the immunization of elderly volunteers against influenza. Methods. Seventy-one elderly volunteers age 61–89 yr were enrolled in a prospective randomized, double-blind study to receive either DHEA (50 mg qd p.o. for four consecutive days

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Hartkamp, A., R. Geenen, G. L. R. Godaert, M. Bijl, J. W. J. Bijlsma, and R. H. W. M. Derksen. "Effects of dehydroepiandrosterone on fatigue and well-being in women with quiescent systemic lupus erythematosus: a randomised controlled trial." Annals of the Rheumatic Diseases 69, no. 6 (2009): 1144–47. http://dx.doi.org/10.1136/ard.2009.117036.

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ObjectiveDehydroepiandrosterone (DHEA) has been reported to improve fatigue and reduced well-being. Both are major problems in patients with systemic lupus erythematosus (SLE), even with quiescent disease. Low serum DHEA levels are common in SLE. The present work investigates the effects of DHEA administration on fatigue, well-being and functioning in women with inactive SLE.MethodsIn a double-blind, randomised, placebo-controlled study, 60 female patients with inactive SLE received 200 mg oral DHEA or placebo. Primary outcome measures were general fatigue, depressive mood, mental well-being a

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Sun, Hongzhi, Weijin Zang, Bo Zhou, Lin Xu, and Shufang Wu. "DHEA Suppresses Longitudinal Bone Growth by Acting Directly at Growth Plate through Estrogen Receptors." Endocrinology 152, no. 4 (2011): 1423–33. http://dx.doi.org/10.1210/en.2010-0920.

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Abstract Dehydroepiandrosterone (DHEA) is produced by the adrenal cortex and is the most abundant steroid in humans. Although in some physiological and pathological conditions the increased secretion of DHEA and its sulfated form is associated with accelerated growth rate and skeletal maturation, it is unclear whether DHEA can affect longitudinal bone growth and skeletal maturation by acting directly at the growth plate. In our study, DHEA suppressed metatarsal growth, growth plate chondrocyte proliferation, and hypertrophy/differentiation. In addition, DHEA increased the number of apoptotic c

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YANASE, TOSHIHIKO, MOTOFUMI FUKAHORI, SUSUMU TANIGUCHI, et al. "Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia." Endocrine Journal 43, no. 1 (1996): 119–23. http://dx.doi.org/10.1507/endocrj.43.119.

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Duan, You Rong, W. S. Liu, J. Liu, and Z. R. Zhang. "A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous." Key Engineering Materials 288-289 (June 2005): 163–66. http://dx.doi.org/10.4028/www.scientific.net/kem.288-289.163.

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The objective of this study was to evaluate the in vivo characteristics of poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene- glycol) (PELGE) copolymers as drug carriers. In order to test this circulation time, mitoxantrone (DHAQ) was used as a model drug in this study. DHAQ nanoparticles (DHAQ-NP) were prepared, subsequently the DHAQ-NP were evaluated by measuring the drug concentration in plasma after intravenous administration via the tail vein of mice. The circulation time of the DHAQ-NP were tested. The results showed prolonged mitoxantrone (DHAQ) residence in system

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Martel, C., A. Sourla, G. Pelletier, et al. "Predominant androgenic component in the stimulatory effect of dehydroepiandrosterone on bone mineral density in the rat." Journal of Endocrinology 157, no. 3 (1998): 433–42. http://dx.doi.org/10.1677/joe.0.1570433.

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In order to assess the relative roles of the androgenic and/or estrogenic components in the stimulatory effect of dehydroepiandrosterone (DHEA) on bone mineral content (BMC) and density (BMD), ovariectomized (OVX) female rats received DHEA administered alone or in combination with the antiandrogen flutamide (FLU) or the antiestrogen EM-800 for 12 months. We also evaluated, for comparison, the effect of estradiol (E2) and dihydrotestosterone (DHT) constantly released by Silastic implants as well as medroxyprogesterone acetate (MPA) released from poly(lactide-co-glycolide) microspheres. Femoral

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Ishizuka, Tatsuo, Kazuo Kajita, Atsushi Miura, et al. "DHEA improves glucose uptake via activations of protein kinase C and phosphatidylinositol 3-kinase." American Journal of Physiology-Endocrinology and Metabolism 276, no. 1 (1999): E196—E204. http://dx.doi.org/10.1152/ajpendo.1999.276.1.e196.

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We have examined the effect of adrenal androgen, dehydroepiandrosterone (DHEA), on glucose uptake, phosphatidylinositol (PI) 3-kinase, and protein kinase C (PKC) activity in rat adipocytes. DHEA (1 μM) provoked a twofold increase in 2-[3H]deoxyglucose (DG) uptake for 30 min. Pretreatment with DHEA increased insulin-induced 2-[3H]DG uptake without alterations of insulin specific binding and autophosphorylation of insulin receptor. DHEA also stimulated PI 3-kinase activity. [3H]DHEA bound to purified PKC containing PKC-α, -β, and -γ. DHEA provoked the translocation of PKC-β and -ζ from the cytos

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Comer, K. A., J. L. Falany, and C. N. Falany. "Cloning and expression of human liver dehydroepiandrosterone sulphotransferase." Biochemical Journal 289, no. 1 (1993): 233–40. http://dx.doi.org/10.1042/bj2890233.

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Dehydroepiandrosterone sulphotransferase (DHEA-ST) catalyses the 3′-phosphoadenosine 5′-phosphosulphate-dependent sulphation of a wide variety of steroids in human liver and adrenal tissue and is responsible for most, if not all, of the sulphation of bile acids in human liver. This report describes the isolation, characterization and expression of a cDNA which encodes human liver DHEA-ST. The DHEA-ST cDNA, designated DHEA-ST8, was isolated from a Uni-Zap XR human liver cDNA library and is composed of 1060 bp and contains an open reading frame encoding a 285-amino-acid protein with a molecular

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Prough, Russell A., Barbara J. Clark, and Carolyn M. Klinge. "Novel mechanisms for DHEA action." Journal of Molecular Endocrinology 56, no. 3 (2016): R139—R155. http://dx.doi.org/10.1530/jme-16-0013.

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Dehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA), secreted by the adrenal cortex, gastrointestinal tract, gonads, and brain, and its sulfated metabolite DHEA-S are the most abundant endogeneous circulating steroid hormones. DHEA actions are classically associated with age-related changes in cardiovascular tissues, female fertility, metabolism, and neuronal/CNS functions. Early work on DHEA action focused on the metabolism to more potent sex hormones, testosterone and estradiol, and the subsequent effect on the activation of the androgen and estrogen steroid receptors. However, it i

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Suarez, C., I. Garcia Tornadu, W. Khalil, and D. Becu-Villalobos. "Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia." Journal of Endocrinology 174, no. 3 (2002): 447–54. http://dx.doi.org/10.1677/joe.0.1740447.

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The physiological importance of and therapeutic interest in dehydroepiandrosterone (DHEA) has been predominantly in relation to its action as an inhibitor of the promotion and progression of several kinds of tumours, including those of breast, prostate, lung, colon, liver and skin tissues. The aim of the present study was to determine the role of DHEA in diethylstilboestrol (DES)-induced pituitary hyperplasia. Female Sprague-Dawley rats were divided into four treatment groups: DES (implanted s.c. with a 20 mg DES pellet), DHEA (two 50 mg DHEA pellets), DHEA/DES (both DHEA and DES pellets), and

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Liu, Dongmin, Mary Iruthayanathan, Laurie L. Homan, et al. "Dehydroepiandrosterone Stimulates Endothelial Proliferation and Angiogenesis through Extracellular Signal-Regulated Kinase 1/2-Mediated Mechanisms." Endocrinology 149, no. 3 (2007): 889–98. http://dx.doi.org/10.1210/en.2007-1125.

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Dehydroepiandrosterone (DHEA) activates a plasma membrane receptor on vascular endothelial cells and phosphorylates ERK 1/2. We hypothesize that ERK1/2-dependent vascular endothelial proliferation underlies part of the beneficial vascular effect of DHEA. DHEA (0.1–10 nm) activated ERK1/2 in bovine aortic endothelial cells (BAECs) by 15 min, causing nuclear translocation of phosphorylated ERK1/2 and phosphorylation of nuclear p90 ribosomal S6 kinase. ERK1/2 phosphorylation was dependent on plasma membrane-initiated activation of Gi/o proteins and the upstream MAPK kinase because the effect was

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Chang, Chia-Che, Yen-Chuan Ou, Shue-Ling Raung, and Chun-Jung Chen. "Antiviral effect of dehydroepiandrosterone on Japanese encephalitis virus infection." Journal of General Virology 86, no. 9 (2005): 2513–23. http://dx.doi.org/10.1099/vir.0.81123-0.

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Japanese encephalitis virus (JEV), which causes neurological disorders, completes its life cycle and triggers apoptotic cell death in infected cells. Dehydroepiandrosterone (DHEA), an adrenal-derived steroid, has been implicated in protection against neurotoxicity and protection of animals from viral-induced encephalitis, resulting in an increased survival rate of the animals. Currently, the mechanisms underlying the beneficial effects of DHEA against the virus are largely unknown. In this study, DHEA suppression of JEV replication and virus-induced apoptosis in murine neuroblastoma (N18) cell

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Fujioka, Kei, Kazuo Kajita, Zhiliang Wu, et al. "Dehydroepiandrosterone reduces preadipocyte proliferation via androgen receptor." American Journal of Physiology-Endocrinology and Metabolism 302, no. 6 (2012): E694—E704. http://dx.doi.org/10.1152/ajpendo.00112.2011.

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Several studies have suggested that both testosterone and dehydroepiandrosterone (DHEA) have weight-reducing and antidiabetic effects, especially in rodent studies; however, the precise mechanism of their action remains unclear. Here, we investigated the effect of DHEA on cell growth in adipose tissue. The appearance of senescence-associated β-galactosidase in stromal vascular fraction (SVF) isolated from Otsuka Long-Evans Tokushima fatty rats, an animal model of inherent obese type 2 diabetes, was prevented by DHEA administration. Next, the effects of DHEA and testosterone were compared in vi

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Rajković Iveta, Marijeta, and Rina Geci. "Albanski zlatari i pekari s Kosova u Zagrebu: Migracije i etničko poduzetništvo." Studia ethnologica Croatica 29 (2017): 279–304. http://dx.doi.org/10.17234/sec.29.10.

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Christiansen, Jens Juel, Claus Højbjerg Gravholt, Sanne Fisker, et al. "Very short term dehydroepiandrosterone treatment in female adrenal failure: impact on carbohydrate, lipid and protein metabolism." European Journal of Endocrinology 152, no. 1 (2005): 77–85. http://dx.doi.org/10.1530/eje.1.01810.

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Objective: In female adrenal insufficiency, dehydroepiandrosterone (DHEA) secretion is impaired and circulating androgen levels are severely reduced. We wanted to analyse the acute effects of physiological DHEA substitution on substrate metabolism. Design: We studied nine females with adrenal insufficiency after 9 days of oral DHEA replacement (50 mg/day) in a double-blind, placebo-controlled crossover study. Methods: Whole body and regional substrate metabolism was assayed in the basal state and during a euglycemic hyperinsulinemic glucose clamp by means of isotope dilution techniques (glucos

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Simoncini, Tommaso, Paolo Mannella, Letizia Fornari, Gaetano Varone, Antonella Caruso, and Andrea R. Genazzani. "Dehydroepiandrosterone Modulates Endothelial Nitric Oxide Synthesis Via Direct Genomic and Nongenomic Mechanisms." Endocrinology 144, no. 8 (2003): 3449–55. http://dx.doi.org/10.1210/en.2003-0044.

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Abstract Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are the major circulating steroid hormones in humans, and their levels progressively decline with age. Epidemiological studies suggest that DHEA/DHEAS concentrations may be inversely related to cardiovascular risk, but disagreement exists on this issue. Preliminary studies show that DHEA regulates vascular function, but few data have been published on the mechanisms. We show that DHEA administration to human endothelial cells triggers nitric oxide synthesis, due to enhanced expression and stabilization of endothelial nitric o

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Stárka, Luboslav, Martin Hill, Richard Hampl та ін. "Studies on the Mechanism of Antiglucocorticoid Action of 7α-Hydroxydehydroepiandrosterone". Collection of Czechoslovak Chemical Communications 63, № 10 (1998): 1683–98. http://dx.doi.org/10.1135/cccc19981683.

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The literature reports that 7α-hydroxydehydroepiandrosterone (7α-OH-DHEA), a metabolite of dehydroepiandrosterone (DHEA), displays numerous anti-aging properties (such as immunostimulation and anti-apoptotic effects) which may result from an apparent antiglucocorticoid activity. However, the molecular mechanism(s) of this effect remain to be elucidated. In the present work, we attempted to unravel some aspects of this mechanism in vitro, in adrenalectomized rats. No specific binding of [3H]-7α-OH-DHEA occurred with the hepatic cytosolic fraction, and the binding of [3H]-dexamethasone ([3H]-DEX

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Wang, Feng, Wei Wang, Kristiina Wähälä, Herman Adlercreutz, Elina Ikonen, and Matti J. Tikkanen. "Role of lysosomal acid lipase in the intracellular metabolism of LDL-transported dehydroepiandrosterone-fatty acyl esters." American Journal of Physiology-Endocrinology and Metabolism 295, no. 6 (2008): E1455—E1461. http://dx.doi.org/10.1152/ajpendo.90527.2008.

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Dehydroepiandrosterone-fatty acyl esters (DHEA-FAE) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives that are transported in circulating lipoproteins and may act as a source of dehydroepiendrosterone (DHEA) and other biologically active steroid hormones in cells. Here, we studied the metabolic fate of low-density lipoprotein-associated [3H]DHEA-FAE ([3H]DHEA-FAE-LDL) and the possible role of lysosomal acid lipase (LAL) in the hydrolysis of DHEA-FAE in cultured human cells. When HeLa cells were incubated with [3H]DHEA-FAE-LDL, the accumulation of label in

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Schulte-Uebbing, Claus. "DHEA-Substitution: Ist 7-Keto-DHEA die bessere Substanz?" Zeitschrift für Orthomolekulare Medizin 9, no. 02 (2011): 10–15. http://dx.doi.org/10.1055/s-0030-1271066.

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