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1

Herrera, Alex F., Matthew Mei, Lawrence Low, et al. "Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation." Journal of Clinical Oncology 35, no. 1 (2017): 24–31. http://dx.doi.org/10.1200/jco.2016.68.2740.

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Purpose Double-hit lymphomas (DHLs) and double-expressor lymphomas (DELs) are subtypes of diffuse large B-cell lymphoma (DLBCL) associated with poor outcomes after standard chemoimmunotherapy. Data are limited regarding outcomes of patients with relapsed or refractory (rel/ref) DEL or DHL who undergo autologous stem-cell transplantation (ASCT). We retrospectively studied the prognostic impact of DEL and DHL status on ASCT outcomes in patients with rel/ref DLBCL. Methods Patients with chemotherapy-sensitive rel/ref DLBCL who underwent ASCT at two institutions and in whom archival tumor material
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Wang, Yingjun, Ken H. Young, Denái R. Milton, et al. "Clinical Relevance of MYC/BCL2 and Cell of Origin in Patients with Relapsed Diffuse Large B-Cell Lymphoma Treated with Autologous Stem Cell Transplantation." Blood 134, Supplement_1 (2019): 2021. http://dx.doi.org/10.1182/blood-2019-126719.

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Purpose: Dual expression of MYC and BCL2 proteins (Double Expressor Lymphoma-[DEL]) and MYC, BCL2 and /or BCL6 translocations (Double Hit Lymphoma-[DHL]) as well as the cell-of-origin (COO) are important prognostic factors in patients (pts) with diffuse large B-cell lymphoma (DLBCL) who are treated with standard chemo-immunotherapy. Data are limited regarding the prognostic impact and interdependence of these biomarkers on outcomes in pts with relapsed DLBCL treated with autologous stem cell transplantation (ASCT). Methods: Data from Pts with relapsed DLBCL who underwent ASCT at our center and
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3

D'Angelo, Christopher, Yanyao Yi, David Yang, and Vaishalee P. Kenkre. "Impact of Initial Treatment Regimen on Outcomes for Diffuse Large B-Cell Lymphoma with Dual MYC and BCL-2 or BCL-6 Expression." Blood 132, Supplement 1 (2018): 2990. http://dx.doi.org/10.1182/blood-2018-99-117449.

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Abstract Introduction: Genetic rearrangements in both the MYC gene and anti-apoptotic genes such as BCL2 or BCL6 in diffuse large B-cell lymphoma (DLBCL) represent a sub-type of lymphoma, termed "double-hit lymphoma" (DHL) that is associated with poor outcomes and a poor response to standard chemoimmunotherapy regimens such as rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) (Petrich et al, Blood, 2014). The incidence of DHL is low at approximately 5-10% of DLBCL presentations. Alternatively, DLBCL cases featuring dual expression of both MYC and BCL-2 and/or BCL-6
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Ding, Wei-Qun, Joshua L. Vaught, Hanako Yamauchi, and Stuart E. Lind. "Differential sensitivity of cancer cells to docosahexaenoic acid–induced cytotoxicity: The potential importance of down-regulation of superoxide dismutase 1 expression." Molecular Cancer Therapeutics 3, no. 9 (2004): 1109–17. http://dx.doi.org/10.1158/1535-7163.1109.3.9.

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Abstract Docosahexaenoic acid (DHA, 22:6 n-3), a polyunsaturated fatty acid found in fish oil, exerts cytotoxic effects on cancer cells. Although DHA was toxic toward five human cancer cell lines (MCF-7, MDA-MB-231, SiHa, Raji, and DHL-4), the lines were not uniformly sensitive. DHL-4, a bcl-2 overexpressing lymphoid line, was the most sensitive (IC50, 5.2 μmol/L) and the cervical cancer cell line, SiHa, was the most resistant (IC50, >300 μmol/L). Lipid peroxidation has been cited by others as an important component of DHA toxicity, and we confirmed that vitamin E prevents the cytotoxic
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Herrera, Alex F., Matthew G. Mei, Lawrence Low, et al. "Double Expressing (MYC/BCL2) and Double-Hit Diffuse Large B-Cell Lymphomas Have Inferior Survival Following Autologous Stem Cell Transplantation." Blood 126, no. 23 (2015): 522. http://dx.doi.org/10.1182/blood.v126.23.522.522.

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Abstract Background: Double-hit lymphomas (DHL) are a subset of diffuse large B-cell lymphoma (DLBCL) with concurrent chromosomal rearrangements involving the MYC and BCL2 or BCL6 genes, and are associated with dismal outcomes with standard upfront therapy. Double expressing lymphomas (DEL) are a subset of DLBCL with co-expression of MYC and BCL2 by immunohistochemistry (IHC), and also have a poor prognosis with standard therapy. While DHL status may be associated with inferior outcomes in patients with relapsed or refractory (rel/ref) disease (Cuccuini, Blood, 2012), little is known about the
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6

Chong, Elise A., Emeline R. Chong, Daniel J. Landsburg, et al. "Anti-CD19 CAR-T for Treatment of Double Expressor and Double Hit Large B-Cell Lymphomas: A Single Institution Real-World Analysis." Blood 136, Supplement 1 (2020): 19–20. http://dx.doi.org/10.1182/blood-2020-143348.

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Introduction: High-grade B cell lymphoma (HGBCL) with rearrangements of MYC in addition to either BCL2 or BCL6 (DHL) generally has a poor prognosis for response to conventional therapies. Nevertheless, current studies of responses to anti-CD19 CAR-T cell therapies (CAR-T) have not demonstrated poorer overall response rates (ORR) in patients with DHL (Locke Lancet Oncol 2019, Schuster NEJM 2019). Double expressor diffuse large B-cell lymphoma (DEL), which lacks the chromosomal rearrangements of DHL but overexpresses MYC and BCL2 proteins by immunohistochemistry, has been similarly associated wi
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7

Herrera, Alex F., Joo Y. Song, Gabriel K. Griffin, et al. "Double-Hit and Double-Expressor Lymphomas Are Not Associated with an Adverse Outcome after Allogeneic Stem Cell Transplantation." Blood 128, no. 22 (2016): 830. http://dx.doi.org/10.1182/blood.v128.22.830.830.

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Abstract Background: Double-hit lymphomas (DHL) - diffuse large B-cell lymphomas (DLBCL) with concurrent rearrangements of MYC and BCL2 and/or BCL6, and double-expressor lymphomas (DEL) - DLBCL with co-expression of MYC and BCL2 by immunohistochemistry (IHC), are associated with poor outcomes after standard chemoimmunotherapy. We have previously demonstrated that patients with relapsed or refractory (rel/ref) DHL and DEL have inferior outcomes after autologous stem cell transplantation (autoSCT) compared to patients with neither DEL nor DHL [Herrera et al, ASH 2015]. Although patients with DEL
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8

Talati, Chetasi, Andrew Kuykendall, Jori Kaplan, et al. "Impact of Serum Albumin in the Prognosis of Myc-Positive Aggressive B-Cell Lymphomas: Potential for a Novel Prognostic Score." Blood 128, no. 22 (2016): 1870. http://dx.doi.org/10.1182/blood.v128.22.1870.1870.

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Abstract Background: MYC positive double hit lymphomas (DHL) (presence of c-myc and BCL2 or BCL6 rearrangements by florescence in situ hybridization (FISH) analysis) and double protein expressor lymphomas (DEL) (protein expression by immunohistochemistry (IHC)) represent a subset of diffuse large B cell lymphomas (DLBCL) with poor prognosis. Several prognostic scores systems have been applied such as the International Prognostic Index (IPI) and Revised IPI (R-IPI) but the most effective score remains to be elucidated. We explored the role of serum albumin (SA) in the prognosis of DHL/DEL as pr
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9

V Ramani, K., and Rick McKinney. "DHL goes ‘open’." Journal of Strategic Information Systems 3, no. 2 (1994): 137–43. http://dx.doi.org/10.1016/0963-8687(94)90013-2.

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Widodo, Agustinus Anung, Wudianto Wudianto, and Agus Setiyawan. "UJICOBA MINI LINE HAULER PADA KAPAL PANCING ULUR TUNA YANG DIOPERASIKAN DI SEKITAR RUMPON DI SAMUDERA HINDIA." Jurnal Penelitian Perikanan Indonesia 25, no. 1 (2019): 45. http://dx.doi.org/10.15578/jppi.25.1.2019.45-54.

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Pancing ulur tuna (dHL) umumnya dioperasikan di sekitar rumpon dengan tali pancing dHL ditarik secara manual saat menangkap ikan tuna. Praktik tersebut berpotensi mengakibatkan kecelakaan kerja bagi nelayan. Penarikan tali pancing dHL secara manual saat pancing dimakan tuna hingga tuna sampai ke dek kapal juga memakan waktu lama. Dalam rangka mengurangi potensi kecelakaan kerja nelayan dHL dan meningkatkan kecepatan tarik tali dHL saat mendapat tuna, maka telah dilakukan ujicoba mini line hauler pada armada dHL. Ujicoba dilakukan pada armada dHL yang berbasis di PPN Prigi tahun 2016. Ujicoba d
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11

Couto Rosa, Sueli de Lourdes. "Los retos del desarrollo humano en el territorio: experiencias en Brasil y Colombia." Equidad y Desarrollo, no. 17 (January 26, 2012): 9. http://dx.doi.org/10.19052/ed.64.

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En este artículo se reflexiona sobre el papel del Estado y el territoriocuando se están abordando procesos de desarrollo humano local. Para esto se analizó el desarrollo, los sustentos teóricos del desarrollo humano local (DHL) y la metodología propuesta por el Programa de Naciones Unidas para el Desarrollo para su consecución en lo local. Finalmente, se hace una revisión de los resultados de la aplicación de la metodología de DHL en Colombia y Brasil, lo que permite concluir que el DHL se diferencia de las demás formas de desarrollo por la formación de capital social y humano, por la generaci
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12

Ma, Zhiping, Jing Niu, Yanzhen Cao, et al. "Clinical significance of ‘double-hit’ and ‘double-expression’ lymphomas." Journal of Clinical Pathology 73, no. 3 (2019): 126–38. http://dx.doi.org/10.1136/jclinpath-2019-206199.

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Background‘Double-hit’ lymphoma (DHL) and ‘double-expression’ lymphoma (DEL) involving gene rearrangement and protein expression of MYC and BCL2/BCL6 have recently become the most commonly used terms to describe the poor prognostic types of diffuse large B-cell lymphoma (DLBCL). However, the clinical and pathological spectra of these rare entities have not been well defined. The aim of this study was to determine the frequency of DHL and DEL in DLBCL and their prognostic impacts in the era of cyclophosphamide, doxorubicin, vincristine and prednisone plus rituximab therapy.MethodsThe data and t
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Medina, M. F., M. I. Bühler, and G. Sánchez-Toranzo. "Chemical activation in Rhinella arenarum oocytes: effect of dehydroleucodine (DhL) and its hydrogenated derivative (2H-DhL)." Zygote 23, no. 6 (2014): 924–32. http://dx.doi.org/10.1017/s0967199414000641.

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SummaryMature oocytes are arrested in metaphase II due to the presence of high levels of active maturation promoting factor (MPF). After fertilization, active MPF levels decline abruptly, enabling oocytes to complete meiosis II. One of the first and universal events of oocyte activation is an increase in cytosolic Ca2+ that would be responsible for MPF inactivation. Mature oocytes can also be activated by parthenogenetic activation. The aims of this work are to test the ability of dehydroleucodine (DhL) and its hydrogenated derivative 11,13-dihydro-dehydroleucodine (2H-DhL) to induce chemical
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14

Mihara, Keichiro, Tetsumi Yoshida, Yoshifumi Takei, Naomi Sasaki, Yoshihiro Takihara, and Tatsuo Ichinohe. "T Cells Bearing Anti-CD19- and/or Anti-CD38-Chimeric Antigen Receptors Effectively Abrogate Primary Double-Hit Lymphoma Cells." Blood 128, no. 22 (2016): 4182. http://dx.doi.org/10.1182/blood.v128.22.4182.4182.

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Abstract Patients with B-cell lymphomas bearing MYC translocation combined with an additional translocation involving other genes, such as BCL2, BCL3, or BCL6, whose category is defined as double-hit lymphoma (DHL), have dismal prognosis, because these cells are refractory to conventional immunochemotherapy. Recent studies have expanded the concept of a such disease entity to include double-expressing lymphomas (DEL) that co-overexpress MYC protein with those proteins, which have also poor prognosis. An adoptive T-cell immunotherapy with a chimeric antigen receptor (CAR) is clinically shown to
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15

Zakar, Rubeena, Sarosh Iqbal, Muhammad Zakria Zakar, and Florian Fischer. "COVID-19 and Health Information Seeking Behavior: Digital Health Literacy Survey amongst University Students in Pakistan." International Journal of Environmental Research and Public Health 18, no. 8 (2021): 4009. http://dx.doi.org/10.3390/ijerph18084009.

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Amid the COVID-19 pandemic, digital health literacy (DHL) has become a significant public health concern. This research aims to assess information seeking behavior, as well as the ability to find relevant information and deal with DHL among university students in Pakistan. An online-based cross-sectional survey, using a web-based interviewing technique, was conducted to collect data on DHL. Simple bivariate and multivariate linear regression was performed to assess the association of key characteristics with DHL. The results show a high DHL related to COVID-19 in 54.3% of students. Most of the
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Toranzo, G. Sánchez, L. A. López, J. Zapata Martínez, M. C. Gramajo Bühler, and M. I. Bühler. "Involvement of the dehydroleucodine alpha-methylene-gamma-lactone function in GVBD inhibition in Bufo arenarum oocytes." Zygote 18, no. 1 (2009): 41–49. http://dx.doi.org/10.1017/s0967199409990086.

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SummaryDehydroleucodine (DhL), a sesquiterpenic lactone, was isolated and purified from aerial parts of Artemisia douglasiana Besser, a medicinal herb used in Argentina. DhL is an alpha-methylene butyro-gamma-lactone ring connected to a seven-membered ring fused to an exocyclic alpha,beta-unsaturated cyclopentenone ringIt has been previously shown that DhL selectively induces a dose-dependent transient arrest in G2 of both meristematic cells and vascular smooth muscle cells. Treatment with DhL induces an inhibition of spontaneous and progesterone-induced maturation in a dose-dependent manner i
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Mustafi, S., M. L. Veisaga, L. A. López, and M. A. Barbieri. "A Novel Insight into Dehydroleucodine Mediated Attenuation ofPseudomonas aeruginosaVirulence Mechanism." BioMed Research International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/216097.

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Increasing resistance ofPseudomonas aeruginosa(P. aeruginosa) to conventional treatments demands the search for novel therapeutic strategies. In this study, the antimicrobial activity of dehydroleucodine (DhL), a sesquiterpene lactone obtained fromArtemisia (A.) douglasiana, was screened against several pathogenic virulence effectors ofP. aeruginosa.In vitro, minimum inhibitory concentration of DhL was determined againstP. aeruginosastrains PAO1, PA103, PA14, and multidrug resistant clinical strain, CDN118. Results showed that DhL was active against each strain where PAO1 and PA103 showed high
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Miyaoka, Masashi, Yara Yukie Kikuti, Joaquim Carreras, et al. "Copy Number Alteration and Mutational Profile of High-Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements, Diffuse Large B-Cell Lymphoma with MYC-Rearrangement, and Diffuse Large B-Cell Lymphoma with MYC-Cluster Amplification." Cancers 14, no. 23 (2022): 5849. http://dx.doi.org/10.3390/cancers14235849.

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Diffuse large B-cell lymphoma (DLBCL) with MYC alteration is classified as high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (double/triple-hit lymphoma; DHL/THL), DLBCL with MYC rearrangement (single-hit lymphoma; SHL) and DLBCL with MYC-cluster amplification (MCAD). To elucidate the genetic features of DHL/THL, SHL, and MCAD, 23 lymphoma cases from Tokai University Hospital were analyzed. The series included 10 cases of DHL/THL, 10 cases of SHL and 3 cases of MCAD. The analysis used whole-genome copy number microarray analysis (OncoScan) and a custom-made next-generatio
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Gunning, Thomas S., Amanda Khoudary, Osairys Billini, et al. "Clinical and sociodemographic factors associated with digital health literacy in patients with non-Hodgkin lymphoma or colorectal carcinoma." Journal of Clinical Oncology 42, no. 16_suppl (2024): 1562. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.1562.

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1562 Background: Digital health literacy (DHL), the capacity to find and understand health information using electronic media, is an emerging social determinant of health. Because DHL may impact patients’ ability to benefit from digital health tools and technology-based models of care, it is important to understand how DHL varies in people with cancer. Methods: Patients (N=105) who received systemic treatment for non-Hodgkin lymphoma (NHL) or colorectal carcinoma (CRC) in the past year were recruited from 3 cancer clinics. Participants self-reported DHL (on the electronic Health Literacy Scale
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Hao, Tu, Suneerat Yangyuen, and Thidarat Somdee. "Digital health literacy levels and influencing factors among college medical students in China during post-COVID-19 pandemic." Journal of Public Health and Development 23, no. 2 (2025): 270–80. https://doi.org/10.55131/jphd/2025/230219.

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Digital health literacy (DHL) is the ability to identify, understand, and use health information from digital sources. DHL may differ among individuals due to many factors. Therefore, this cross-sectional study investigated DHL and its associated factors among 1065 vocational college medical students in Sichuan, China, after the COVID-19 pandemic. Their demographic data were collected using a DHL questionnaire, and their health information seeking was rated. Multivariate logistic regression was used to evaluate how different factors influenced DHL. The participants had a median age of 19 years
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Khurana, Arushi, Raphael Mwangi, James R. Cerhan, et al. "Comparing Clinical Characteristics and Outcomes of MYC and BCL6 Double Hit Lymphoma (DHL- BCL6) with Other Aggressive B-Cell Lymphomas: Understanding the Impact of New Who and International Consensus Classifications." Blood 142, Supplement 1 (2023): 67. http://dx.doi.org/10.1182/blood-2023-190316.

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Background: High Grade B cell Lymphoma (HGBL) with MYC and BCL2 and/or BCL6 rearrangements(R) was introduced as an entity in 2016 by the WHO revised 4 th edition. In 2022, both the WHO 5 th edition (beta version) and the International Consensus Classification (ICC) separated DHL- BCL2 (+/- BCL6-R)from DHL- BCL6 given differences in biology . However, while the ICC has maintainedDHL- BCL6 as a provisional entity, the WHO has removed the category, thus removing the requirement to FISH for BCL6-R in this setting. Clinical data on DHL- BCL6 is much more limited, as these cases represent only 10-20
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Khan, M. Shamim, Alex Chong, and Tom Gedeon. "A Methodology for Developing Adaptive Fuzzy Cognitive Maps for Decision Support." Journal of Advanced Computational Intelligence and Intelligent Informatics 4, no. 6 (2000): 403–7. http://dx.doi.org/10.20965/jaciii.2000.p0403.

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Differential Hebbian Learning (DHL) was proposed by Kosko as an unsupervised learning scheme for Fuzzy Cognitive Maps (FCMs). DHL can be used with a sequence of state vectors to adapt the causal link strengths of an FCM. However, it does not guarantee learning of the sequence by the FCM and no concrete procedures for the use of DHL has been developed. In this paper a formal methodology is proposed for using DHL in the development of FCMs in a decision support context. The four steps in the methodology are: (1) Creation of a crisp cognitive map; (2) Identification of event sequences for use in
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Maulana, Wisnu Sukma. "EMPLOYEE EVALUATION INFORMATION SYSTEM PT. DHL EXPRESS INDONESIA WITH TIMESHEET PARAMETERS / ONLINE ABSENCE WITH OPENID AND OAUTH2 SECURITY." International Journal Science and Technology 1, no. 1 (2022): 55–62. http://dx.doi.org/10.56127/ijst.v1i1.566.

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PT DHL Express Indonesia (DHL) is a courier and freight forwarding service company between regions in Indonesia. Bearing in mind the vast territory in Indonesia, DHL records 314 thousand shipments per year or 860 shipments per visit. In order to improve the shipping service, DHL took the initiative to request a system that could support the timesheet or the attendance of its couriers properly and safely. Making an absent or online attendance system using two security technologies namely OpenID and Oauth2. Both of these security technologies guarantee timesheet data leakage or absenteeism from
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Merchant, Hemant, Masud Chand, and Caroline Michiels. "DHL Bangladesh: Managing headquarters-subsidiary relationsComment on DHL Bangladesh: Managing headquarters-subsidiary relations." Thunderbird International Business Review 50, no. 3 (2008): 201–14. http://dx.doi.org/10.1002/tie.20195.

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Cheng, Wei, Miao Miao, Luying Jiao, and Xin Liu. "How digital health literacy shapes health: Mediating role of physical activity and heterogeneity in China." PLOS One 20, no. 7 (2025): e0328101. https://doi.org/10.1371/journal.pone.0328101.

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Purpose This study systematically examines the impact of digital health literacy (DHL) on the physical and mental health of Chinese adults, particularly focusing on how DHL might enhance physical health through physical activity (PA) mediation. Methods Drawing on nationally representative Chinese data, this study employed multivariable linear regression combined with mediation analysis to assess the association between DHL and adult health outcomes, while evaluating the mediating role of PA. Robustness was verified through propensity score matching (PSM), logistic regression, and mediation eff
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Patil, Uday, Uliana Kostareva, Molly Hadley, et al. "Health Literacy, Digital Health Literacy, and COVID-19 Pandemic Attitudes and Behaviors in U.S. College Students: Implications for Interventions." International Journal of Environmental Research and Public Health 18, no. 6 (2021): 3301. http://dx.doi.org/10.3390/ijerph18063301.

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The COVID-19 pandemic has been accompanied by rapidly emerging evidence, changing guidance, and misinformation, which present new challenges for health literacy (HL) and digital health literacy (DHL) skills. This study explored whether COVID-19-related information access, attitudes, and behaviors were associated with health literacy and digital health literacy among college students in the United States. Self-reported measures of health literacy, along with items on pandemic-related attitudes, behaviors, information sources, and social networks, were collected online using a managed research p
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Rosário, Rafaela, Maria R. O. Martins, Cláudia Augusto, et al. "Associations between COVID-19-Related Digital Health Literacy and Online Information-Seeking Behavior among Portuguese University Students." International Journal of Environmental Research and Public Health 17, no. 23 (2020): 8987. http://dx.doi.org/10.3390/ijerph17238987.

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We aim to evaluate the associations between digital health literacy (DHL) related to COVID-19 and online information-seeking behavior among university students. Methods: A total of 3.084 students (75.7% women), with an average age of 24.2 (SD = 7.5) participated in this cross-sectional study, most of whom (36.5%) were from social sciences and pursued a bachelor’s degree (50.7%). Data on COVID-19-related DHL and online information-seeking behavior were collected using an online questionnaire. Logistic regression models were performed. Results: As the pandemic progressed, participants showed a l
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Adam, Hilman. "Telaah Penggunaan Literasi Kesehatan Digital Pada Mahasiswa Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi." Jurnal Lentera - Penelitian dan Pengabdian Masyarakat 2, no. 2 (2022): 27–30. http://dx.doi.org/10.57207/lentera.v2i2.27.

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Literasi kesehatan digital merupakan kemampuan untuk mencari, menemukan, memahami dan menafsir informasi kesehatan dari sumber elektronik dan menerapkan pengetahuan yang diperoleh untuk mengatasi atau memecahkan masalah kesehatan. Tujuan dari penelitian ini adalah untuk menelaah penggunaan literasi kesehatan digital, pada mahasiswa Fakultas Kesehatan Masyarakat, Universitas Sam Ratulangi. Penelitian dilakukan secara daring, melalui metode survey deskriptif, dengan desain studi potong lintang. Penelitian diikuti oleh 232 responden yang dilaksanakan pada minggu ke 2 bulan Desember 2021. Hasil pe
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Dang, Yibo, Manjeet Singh, and Theodore T. Allen. "Network Mode Optimization for the DHL Supply Chain." INFORMS Journal on Applied Analytics 51, no. 3 (2021): 179–99. http://dx.doi.org/10.1287/inte.2020.1046.

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DHL Supply Chain North America moves more than 20 million packages each year. DHL transportation planners perform routing and cost-deduction tasks for many business projects. We refer to the associated planning problem as the Vehicle Routing Problem with Time Regulations and Common Carriers (VRPTRCC). Unlike ordinary vehicle routing problems, which use only a single type of transportation mode, our VRPTRCC applications include make–buy decisions because some of the package deliveries are ultimately subcontracted to organizations other than DHL. Time regulation means that the problem considers
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Canel, N., R. Bevacqua, and D. Salamone. "47 ACTIVATION WITH IONOMYCIN FOLLOWED BY DEHYDROLEUCODINE AND CYTOCHALASIN B OF CLONED BOVINE EMBRYOS." Reproduction, Fertility and Development 22, no. 1 (2010): 181. http://dx.doi.org/10.1071/rdv22n1ab47.

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A combined treatment of dehydroleucodine (DhL) and cytochalasin B (CB) was previously demonstrated to induce pronuclear formation of bovine oocytes (Canel and Salamone 2008 Reprod. Fertil. Dev. 21, 214-215). The aim of this study was to evaluate the potential of DhL combined with CB to induce diploid activation of parthenogenetic embryos and to employ this treatment to assist cloning by intracytoplasmic injection of whole cumulus cells. To do that, COCs were collected from cow ovaries obtained from a slaughterhouse and in vitro-matured in TCM-199, at 39°C under 6% CO2 in air for 24 h. After re
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Liao, Chengcheng, Sha He, Jie Sun, et al. "A Focused High Throughput Functional Screen Identifies Novel Targets for aggressive B-Cell Lymphoma." Blood 144, Supplement 1 (2024): 5758. https://doi.org/10.1182/blood-2024-209515.

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Introduction: Diffuse large B-cell lymphoma is an aggressive cancer that arises from B-cells and accounts for about 30-40% of all non-Hodgkin lymphoma cases. Genetically, it can be classified as single-hit (SHL: has rearrangement in one of the three genes i.e., MYC, BCL2 or BCL6, typically MYC), double-hit (DHL: involves rearrangements in two of these genes, commonly MYC and either BCL2 or BCL6), triple-hit (THL: involving rearrangements in MYC, BCL2, and BCL6 genes) or no hit (NHL: with no rearrangements in any of these genes). Double and triple hit lymphomas are aggressive with the poor prog
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Álvarez-Pérez, Yolanda, Lilisbeth Perestelo-Pérez, Amado Rivero-Santanta, et al. "Co-Creation of Massive Open Online Courses to Improve Digital Health Literacy in Pregnant and Lactating Women." International Journal of Environmental Research and Public Health 19, no. 2 (2022): 913. http://dx.doi.org/10.3390/ijerph19020913.

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Background: Digital health literacy (DHL) increases the self-efficacy and empowerment of pregnant and lactating women (PLW) in using the Internet for health issues. The European project IC-Health aimed to improve DHL among PLW, through the co-creation of Massive Open Online Courses (MOOCs). Methods: The co-creation of the MOOCs included focus groups and the creation of communities of practice (CoPs) with PLW and healthcare professionals aimed to co-design the MOOCs. The quantitative measures of MOOCs’ acceptability, experience in the co-creation process and increase in DHL (dimensions of findi
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Yoon, Hee-Soo, Hee-Yeon Kim, Kyung-Ah Cho, et al. "Procollagen C-Endopeptidase Enhancer 2 Secreted by Tonsil-Derived Mesenchymal Stem Cells Increases the Oxidative Burst of Promyelocytic HL-60 Cells." Biology 11, no. 2 (2022): 255. http://dx.doi.org/10.3390/biology11020255.

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Reactive oxygen species (ROS) generated by neutrophils provide a frontline defence against invading pathogens. We investigated the supportive effect of tonsil-derived mesenchymal stem cells (TMSCs) on ROS generation from neutrophils using promyelocytic HL-60 cells. Methods: Differentiated HL-60 (dHL-60) cells were cocultured with TMSCs isolated from 25 independent donors, and ROS generation in dHL-60 cells was measured using luminescence. RNA sequencing and real-time PCR were performed to identify the candidate genes of TMSCs involved in augmenting the oxidative burst of dHL-60 cells. Transcri
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ПЕТЕРБУРГСКИЙ, М. А., and Л. В. ПОЛЫНОВА. "LOGISTICS ORGANIZATION BASED ON PROJECT MANAGEMENT." Экономика и предпринимательство, no. 5(154) (July 1, 2023): 995–97. http://dx.doi.org/10.34925/eip.2023.154.5.199.

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В данной статье рассматривается организация транспортной логистики на основе проектного управления, даётся определение логистики и логистического проекта. Рассматривается деятельность компании DHL. Проводится анализ организации проектного управления на основании опыта компании DHL. Выявляются основные проблемы и пути их решения. This article discusses the organization of transport logistics based on project management, defines logistics and logistics project. The activities of DHL are being considered. The analysis of the organization of project management based on the experience of DHL is car
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Toruan, Parmin lumban, Rahmwati ,, and Andi Arief Setiawan. "Konduktivitas Listrik Ion Terlarut: Studi Kasus di Air Sumur TPA Sukawinatan Palembang." Jurnal Redoks 7, no. 1 (2022): 48–54. http://dx.doi.org/10.31851/redoks.v7i1.6760.

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Daya Hantar Listrik (DHL) atau konduktivitas dalam air  menunjukkan banyaknya kandungan ion-ion terlarut dalam air tersebut. Pemukiman penduduk di Tempat Pembuangan Akhir (TPA) Sukawinatan Palembang, sangat rentan akan pencemaran dari air lindi sampah yang masuk ke sumur pemukiman masyarakat setempat. Parameter DHL dapat ditentukan dengan enggunakan Rangkaian Jembatan Wheatstone (RJW).  Penelitian ini bertujuan untuk mengkaji besarnya DHL di air sumur masyarakat yang bermukim di TPA tersebut. Hasil penelitian menunjukkan bahwa nilai tertinggi DHL sebesar 90,1526.10-5 Ωm-1 dan terendah 26,6
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Wu, Ya-Xian, Feng-Juan Jiang, Gang Liu, et al. "Dehydrocostus Lactone Attenuates Methicillin-Resistant Staphylococcus aureus-Induced Inflammation and Acute Lung Injury via Modulating Macrophage Polarization." International Journal of Molecular Sciences 22, no. 18 (2021): 9754. http://dx.doi.org/10.3390/ijms22189754.

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Dehydrocostus lactone (DHL), a natural sesquiterpene lactone isolated from the traditional Chinese herbs Saussurea lappa and Inula helenium L., has important anti-inflammatory properties used for treating colitis, fibrosis, and Gram-negative bacteria-induced acute lung injury (ALI). However, the effects of DHL on Gram-positive bacteria-induced macrophage activation and ALI remains unclear. In this study, we found that DHL inhibited the phosphorylation of p38 MAPK, the degradation of IκBα, and the activation and nuclear translocation of NF-κB p65, but enhanced the phosphorylation of AMP-activat
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Ren, Yuan, Chengfeng Bi, Xiaohong Zhao, et al. "Pharmacoproteomics Identifies PLK1 As Vulnerability for Aggressive B-Cell Lymphomas." Blood 132, Supplement 1 (2018): 2853. http://dx.doi.org/10.1182/blood-2018-99-118004.

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Abstract Background: c-MYC is a transcription factor that promotes oncogenesis by activating and repressing its target genes that control cell growth, metabolism, and proliferation. MYC is deregulated in a large proportion of aggressive B-cell lymphomas. A typical example is the Double-Hit Lymphoma (DHL) and Double-Expression Lymphoma (DEL) which present with a rapidly progressing clinical course, refractory to treatment, poor clinical outcome, and currently considered incurable. Nevertheless, MYC is considered as an "undruggable" target since it has no "active site" amenable to binding by con
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Bökamp, Lena. "Jet-Tankstellen mit DHL-Packstationen." Lebensmittel Zeitung 73, no. 10 (2021): 45. http://dx.doi.org/10.51202/0947-7527-2021-10-045-4.

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Giuri, Maurizio. "DHL bestellt erste Elektro-Flugzeuge." Lebensmittel Zeitung 73, no. 31 (2021): 25. http://dx.doi.org/10.51202/0947-7527-2021-31-025-4.

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Rode, Jörg. "Metro Logistics gewinnt DHL-Auftrag." Lebensmittel Zeitung 73, no. 39 (2021): 41. http://dx.doi.org/10.51202/0947-7527-2021-39-041-5.

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41

Church, James A. "Dag Hammarskjöld Library (DHL) Website." Journal of Government Information 27, no. 3 (2000): 393–95. http://dx.doi.org/10.1016/s1352-0237(00)00177-5.

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Lumban Toruan, Parmin Lumban Toruan, Bella Margareta, Asiah Jumarni, Syahnas Ski Pratiwi, and Atina Atina. "PENGARUH TEMPERATUR AIR TERHADAP KONDUKTIVITAS DAN TOTAL DISSOLVED SOLID." Jurnal Kumparan Fisika 6, no. 1 (2023): 11–16. http://dx.doi.org/10.33369/jkf.6.1.11-16.

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ABSTRAK Kandungan mineral dalam air minum merupakan unsur yang penting dalam tubuh serta bermanfaat bagi sistem pencernaan. Air minum yang berkualitas harus sesuai dengan standar yang telah ditetapkan resmi oleh Peraturan Menteri Kesehatan RI No. 482/MENKES/PER/IV/2010. Penelitian ini bertujuan untuk menganalisis kenaikan temperatur air minum terhadap daya hantar listrik (DHL) dan total dissolved solid (TDS). Variasi temperatur dilakukan sebanyak 8 kali dengan kenaikan 10oC yaitu 10oC, 20oC, 30oC, 40oC, 50oC, 60oC, 70oC, dan 80oC. Metode yang digunakan yaitu metode eksperimen di Laboratorium m
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Shen, Yige, Shu Cheng, Pengpeng Xu, Li Wang, and Weili Zhao. "Clinical and Molecular Features of Patients with Double/Triple Hit Large B-Cell Lymphoma." Blood 142, Supplement 1 (2023): 4488. http://dx.doi.org/10.1182/blood-2023-188042.

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Background: High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) is a recently defined category in the latest revision of the World Health Organization (WHO) classification, which comprises approximately 5-15% of newly diagnosed DLBCL. This subtype of lymphoma poses numerous challenges from diagnosis to treatment of patients. On the one hand, diagnosis of HGBL-DH/TH requires the accomplishment of fluorescent in-situ hybridization (FISH) to identify the translocations of MYC(8q24) and BCL2(18q21) or/and BCL6(3q27), with no consensus being reached regarding the mo
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Swerdlow, Steven H. "Diagnosis of ‘double hit’ diffuse large B-cell lymphoma and B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma: when and how, FISH versus IHC." Hematology 2014, no. 1 (2014): 90–99. http://dx.doi.org/10.1182/asheducation-2014.1.90.

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Abstract Identification of large B-cell lymphomas that are “extra-aggressive” and may require therapy other than that used for diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), is of great interest. Large B-cell lymphomas with MYC plus BCL2 and/or BCL6 rearrangements, so-called ‘double hit’ (DHL) or ‘triple hit’ (THL) lymphomas, are one such group of cases often recognized using cytogenetic FISH studies. Whether features such as morphologic classification, BCL2 expression, or type of MYC translocation partner may mitigate the very adverse prognosis of DHL/THL is controversia
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Caldeira, Wanessa Santos, Mirian Ueda Yamaguchi, and Rute Grossi Milani. "Digital health literacy and diet quality." Concilium 24, no. 16 (2024): 76–95. http://dx.doi.org/10.53660/clm-3907-24q27.

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The objective of this study was to evaluate the correlation between the level of digital health literacy (DHL) and diet quality (DQ). Information was collected from users of digital social networks through online questionnaires containing sociodemographic data, questions from the Digital Health Literacy Instrument and a 24-hour recall. To verify the correlation between the level of DHL and QD, the Spearman correlation test and the chi-square test were applied for the association between DHL and QD with sociodemographic factors. The diet of 71% of respondents was classified as “needs modificati
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Wibowo, Dimas Aryo, Puguh D. Raharjo, Eko Puswanto, Sueno Winduhutomo, Mohammad Al Afif, and Sugeng P. Saputro. "Identifikasi Pencemaran Airtanah Bebas Menggunakan Geolistrik di Lokasi Sekitar Industri Penyamakan Kulit." Majalah Geografi Indonesia 35, no. 1 (2021): 22. http://dx.doi.org/10.22146/mgi.61106.

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Identifikasi pencemaran airtanah pada limbah cair penyamakan kulit dapat dilakukan dengan metode geolistrik karena limbah cair industri penyamakan kulit mengandung unsur logam berat krom yang berpengaruh terhadap nilai Daya Hantar Listrik (DHL) dan nilai tahanan jenis airtanah. Penelitian ini dilakukan di sebagian Desa Sitimulyo, Piyungan, Bantul. Oleh karena itu tujuan dari penelitian ini adalah 1) memetakan pencemaran airtanah oleh limbah cair industri penyamakan kulit berdasarkan persebaran nilai DHL dan 2) mengidentifikasi pencemaran airtanah oleh limbah cair di sekitar kawasan industri pe
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Gunning, Thomas S., Amanda Khoudary, Isabella Westervelt, et al. "Digital Health Literacy in Patients with Non-Hodgkin Lymphoma: Informing Intervention Approaches to Address Financial Toxicity." Blood 142, Supplement 1 (2023): 7348. http://dx.doi.org/10.1182/blood-2023-175021.

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Introduction: Financial toxicity is the harmful effect of treatment costs on a patient's quality of life. Financial toxicity is common among cancer patients, and patients with hematologic malignancies often report worse financial toxicity than patients with other cancers. Thus, interventions to address financial toxicity in patients with hematologic cancers are urgently needed. Promising approaches include the use of digital media such as websites and educational videos. However, digital interventions may not be accessible for patients with low digital health literacy (DHL; the capacity to fin
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Bak, Carsten K., Jeanne Ø. Krammer, Kevin Dadaczynski, et al. "Digital Health Literacy and Information-Seeking Behavior among University College Students during the COVID-19 Pandemic: A Cross-Sectional Study from Denmark." International Journal of Environmental Research and Public Health 19, no. 6 (2022): 3676. http://dx.doi.org/10.3390/ijerph19063676.

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The COVID-19 pandemic and the concomitant infodemic have emphasized the importance of digital health literacy (DHL) to global public health research and practice. The aim of this study was to examine information-seeking behavior, the ability to find, understand and deal with health information among university college students in Denmark and/in addition we wanted to examine the impact of their close social network on students’ ability to find and understand health information. This research was carried out as part of the COVID-HL university student survey by using a uniform questionnaire consi
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Chen, Sheng-Chih, Le Duc Huy, Cheng-Yu Lin, et al. "Association of Digital Health Literacy with Future Anxiety as Meditated by Information Satisfaction and Fear of COVID-19: A Pathway Analysis among Taiwanese Students." International Journal of Environmental Research and Public Health 19, no. 23 (2022): 15617. http://dx.doi.org/10.3390/ijerph192315617.

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Digital Health Literacy (DHL) helps online users with navigating the infodemic and co-existing conspiracy beliefs to avoid mental distress and maintain well-being. We aimed to investigate the association between DHL and future anxiety (FA); and examine the potential mediation roles of information satisfaction and fear of COVID-19 (F-CoV). A web-based cross-sectional survey was carried out among 1631 Taiwanese university students aged 18 years and above from June 2021 to March 2022. Data collected were socio-demographic characteristics (sex, age, social status, university location), information
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Rosário, Rafaela, Sara Barros Araújo, Ana Silva, and Sílvia Barros. "Roles of the interaction with children and families in mediating the association between digital health literacy and well-being of early childhood teachers in Portugal: A cross-sectional study." PLOS ONE 18, no. 9 (2023): e0291748. http://dx.doi.org/10.1371/journal.pone.0291748.

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Aim To analyze the associations between early childhood education (ECE) teachers´ digital health literacy (DHL) and well-being, and to determine whether the ECE teachers´ interaction with children and family mediated these associations. Methods A total of 853 early childhood teachers, predominantly women (99.4%) participated in this cross-sectional study. The participants had a mean age of 39.9 years (standard deviation SD = 8.2). Data was collected through an online survey. DHL was assessed using five subscales adapted to the new coronavirus context, and the professionals´ well-being was meas
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