Relevant bibliographies by topics / Diabetes Mellitu

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Academic literature on the topic 'Diabetes Mellitu'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 March 2023

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Journal articles on the topic "Diabetes Mellitu"

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Sofiana, Rosita, and Sutikno Sutikno. "Optimization of Backpropagation for Early Detection of Diabetes Mellitu." International Journal of Electrical and Computer Engineering (IJECE) 8, no. 5 (October 1, 2018): 3232. http://dx.doi.org/10.11591/ijece.v8i5.pp3232-3237.

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Diabetes mellitus is one of the urgent health problems in the world. Diabetes is a condition primarily defined by the level of hyperglycemia giving rise to risk of micro vascular damage. Those who suffer from this disease generally do not realize and tend to overlook the early symptoms. Late recognition of these early symptoms may drive the disease to a more concerning level. One solution to solve this problem is to create an application that may perform early detection of diabetes mellitus so that it does not grow larger. In this article, a new method in performing early detection of diabetes mellitus is suggested. This method is backpropagation with three optimization namely early initialization with Nguyen-Widrow algorithm, learning rate adaptive determination, and determination of weight change by applying momentum coefficient. The observation is conducted by collecting 150 data consisting of 79 diabetes mellitus patient and 71 non diabetes mellitus patient data. The result of this study is the suggested algorithm succeeds in detecting diabetes mellitus with accuracy rate of 99.33%. Optimized backpropagation algorithm may allow the training process goes 12.4 times faster than standard backpropagation.
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G.A., Akhmedov. "Значимость аутоантител при инсулинзависимом сахарном диабете." Kazanskiy meditsinskiy zhurnal 98, no. 4 (2017): 519–21. http://dx.doi.org/10.17750/kmj2017-519.

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Kudlová, Pavla, and Ilona Kočvarová. "Knowledge and self-assessment of general practitioner nurses in the area of diabetes mellitus." Kontakt 22, no. 3 (August 28, 2020): 165–71. http://dx.doi.org/10.32725/kont.2020.031.

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Becerra, Jose E., Muin J. Khoury, Jose F. Cordero, and J. David Erickson. "Diabetes Mellitus During Pregnancy and the Risks for Specific Birth Defects: A Population-Based Case-Control Study." Pediatrics 85, no. 1 (January 1, 1990): 1–9. http://dx.doi.org/10.1542/peds.85.1.1.

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Although the excess risk for birth defects among children of mothers with diabetes mellitus is well documented, there are few data concerning the risk for specific malformations. In the Atlanta Birth Defects Case-Control Study, those risks for malformations were evaluated. The population-based study included 4929 live and stillborn babies with major malformations ascertained by the Metropolitan Atlanta Congenital Defects Program in the first year of life born to residents of Metropolitan Atlanta between 1968 and 1980. The study also included 3029 nonmalformed live babies who were frequency-matched to case babies by race, period of birth, and hospital of birth. The relative risk for major malformations among infants of mothers with insulin-dependent diabetes mellitu (n = 28) was 7. (5% confidence interval [CI]1.9, 33.5) compared with infants of nondiabetic mothers. The relative risks for major central nervous system and cardiovascular system defects were 15.5 (95% CI = 3.3, 73.8) and 18.0 (95% CI = 3.9, 82.5), respectively. The absolute risks for major, central nervous system, and cardiovascular system malformations among infants of diabetic mothers were 18.4, 5.3, and 8.5 per 100 live births, respectively. Infants of mothers with gestational diabetes mellitus who required insulin during the third trimester of pregnancy were 20.6 (95% CI = 2.5, 168.5) times more likely to have major cardiovascular system defects than infants of nondiabetic mothers. The absolute risk for infants of this group of diabetic mothers was 9.7%. No statistically significant differences were found among infants of mothers with gestational diabetes mellitus who did not require insulin during pregnancy. These results suggest a stronger association than previously reported between maternal diabetes mellitus and specific categories of major malformations and implicate gestational diabetes mellitus as a risk factor for major cardiovascular system defects.
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Hermayanti, Diah, and Erlin Nursiloningrum. "HIPERGLIKEMIA PADA ANAK." Saintika Medika 13, no. 1 (March 28, 2018): 25. http://dx.doi.org/10.22219/sm.v13i1.5443.

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Pendahuluan Diabetes mellitus (DM) merupakan penyakit metabolik ditandai oleh hiperglikemia yang disebabkan berkurangnya produksi atau kerja insulin. DM dapat menyerang anak-anak. Kami melaporkan kasus hiperglikemia pada anak berusia 9 tahun dengan kadar C-peptida dalam batas normal. KasusAnak perempuanberusia 9 tahun, dibawa ke rumah sakit dikeluhkan lemah badan selama satu minggu. Pasien juga dikeluhkan sering kencing terutama di malam hari selama sebulan dan bekas kencing dirubung oleh semut. Pemeriksaan fisik dalam batas normal. Pemeriksaan laboratorium hari pertama : hemoglobin 14,8 g/dl, leukosit 9.860 sel/ul, trombosit 297.000 sel/ul, gula darah acak 328 mg/dl. Pemeriksaan hari kedua : gula darah puasa 274 mg/dl, gula darah 2 jam post prandial 370 mg/dl, dan glukosuria. Pemeriksaan C-Peptida 2,74 ng/ml (normal 1,1 – 4,4 ng/ml)PembahasanPada pasien anak ini ditemukan gejala khas diabetes yaitu fatigue dan poliuri. Pada pemeriksaan laboratorium didapatkan hiperglikemia. Sesuai dengan pedoman dari PERKENI pasien ini didiagnosis sebagai DM, yaitu tipe-1, dengan diferential diagnosis Maturity onset diabetes of the young (MODY) mengingat kadar C-peptida dalam batas normal. DM tipe 1 disebabkan oleh karena kerusakan sel beta pankreas akibat adanya autoantibodi terhadap pankreas. Sedangkan MODY disebabkan oleh mutasi genetik pada sel â pankreas sehingga terjadi inefektifitas produksi atau gangguan pelepasan insulin. Pemeriksaan tambahan seperti deteksi antibodi sel islet disarankan untuk menetapkan diagnosis DM tipe 1, dan pemeriksaan genetik untuk mendeteksi terjadinya mutasi sel â pankreas. SimpulanDiagnosis Type-1 Diabetes mellitu, dengan diagnosis banding Maturity onset diabetes of the young(MODY)Kata Kunci: hiperglikemia anak, C-peptida, Diabetes mellitus tipe-1, MODY
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Santulli, G. "Thrombolysis Outcomes in Acute Ischemic Stroke Patients With Prior Stroke and Diabetes Mellitu." Neurology 78, no. 11 (March 13, 2012): 840. http://dx.doi.org/10.1212/wnl.0b013e31824de51b.

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Dielievska, V. Yu, and I. P. Dunaeva. "AUTOIMMUNE MECHANISMS OF CHRONIC HEART FAILURE PROGRESSION IN ARTERIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH CONCOMITANT TYPE 2 DIABETES MELLITU." Problems of Endocrine Pathology 55, no. 1 (March 2, 2016): 23–28. http://dx.doi.org/10.21856/j-pep.2016.1.03.

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We examined whether autoantibodies against type IV collagen are associated with heart failure progression in arterial hypertension combined with chronic obstructive pulmonary disease with and without type 2 diabetes mellitus. Both patients with chronic heart failure in essential hypertension and chronic obstructive pulmonary disease and patients with concomitant type 2 diabetes mellitus showed higher levels of plasma type IV collagen autoantibodies in comparison to healthy controls. Type IV collagen antibodies correlated with dilation of the left ventricle and reduction of its contractility. Elevation of plasma type IV collagen autoantibodies is associated with progression of chronic heart failure in arterial hypertension combined and chronic obstructive pulmonary with and without type 2 diabetes mellitus.
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Zilli Réus, Gislaine, Maria Augusta Bernardini dos Santos, Helena Mendes Abelaira, Amanda Luis Maciel, Camila Orlandi Arent, Beatriz Iladi Matias, Lívia Bruchchen, et al. "Antioxidant Therapy Alters Brain MAPK-JNK and BDNF Signaling Path-ways in Experimental Diabetes Mellitu s." Current Neurovascular Research 13, no. 2 (March 31, 2016): 107–14. http://dx.doi.org/10.2174/1567202613666160219115832.

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Shi, L., X. Ye, M. Lu, E. Q. Wu, H. Sharma, D. Thomason, and V. Fonseca. "Economic Outcomes Associated With Hba1c And Ldl-C Goal Achievement In Patients With Type 2 Diabetes Mellitu." Value in Health 16, no. 3 (May 2013): A172. http://dx.doi.org/10.1016/j.jval.2013.03.863.

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González-Escobar, Dianne Sofía, and Olga Marina Vega-Angarita. "Comparación entre la habilidad de cuidado de cuidadores de pacientes con enfermedad cerebrovascular Y diabetes mellitus en san josé de cúcuta, norte de santander." Respuestas 12, no. 2 (May 16, 2016): 5–17. http://dx.doi.org/10.22463/0122820x.559.

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Objetivo:Comparar la habilidad de cuidado de los cuidadores familiares de pacientes por Diabetes Mellitus y Enfermedad Cerebrovascular en San José de Cúcuta, Norte de Santander. Materiales y Métodos:Corresponde a un diseño de tipo descriptivo comparativo con abordaje cuantitativo en 128 cuidadores familiares de pacientes (64 por Enfermedad Cerebrovascular y 64 por Diabetes mellitus). Resultados:Contienen la descripción de los grupos a estudio en términos de sexo, edad, nivel de escolaridad, estado civil, ocupación, nivel socioeconómico, cuidado desde el momento del diagnóstico, tiempo de cuidado y parentesco con la persona cuidada; nivel de funcionalidad del receptor de cuidado de acuerdo con su capacidad física y cognitiva. El nivel de habilidad total y de sus dimensiones: Conocimiento, Valor y Paciencia se comparan en los dos grupos de cuidadores. El estudio reporto similitud en las características sociodemográficas de la población participante, como en el nivel de funcionalidad de los receptores de cuidado. Discusión:Los hallazgos del estudio confirman lo reportado en la literatura de enfermería respecto a las características sociodemográficas y niveles deficientes en la habilidad de cuidado. En cuanto a los componentes que integran la habilidad de cuidado: conocimiento, valor y paciencia, se encuentran diferencias estadísticamente significativas entre los dos grupos, reportando los cuidadores familiares de pacientes diabéticos mayores niveles de conocimiento y paciencia. Respecto al componente valor no se encontró diferencia significativa entre los grupos a estudio.Palabras Clave : Cuidadores; Habilidad; Enfermedad Cerebrovascular; Diabetes Mellitus. SUMMARY Objective : To compare the care ability among the family caretakers of patients with Mellitus Diabetes and Cerebral Vascular diseases in San Jose de Cucuta, Norte de Santander. Materials And Methodology: It corresponds to a descriptive and comparative type of quantitative approach among the family caretakers of 64 Cerebral Vascular disease and 64 Mellitus Diabetes disease patients.Results: It contents a description of the study groups about the gender, age, school level, civil status, occupation, socio-economical level, time and care of the patient from diagnosis, kinship, and the level of potential functions on the receptor of the care according to their physical and cognitive capacities. The level of the total ability and its dimensions such as Knowledge, Courage and Patience are compared between the caretakers groups. The study showed similarity in the socio-demographic characteristics of the participants, as of in the level of potential functions on the receptors of the care.Argument: The findings of the study confirmed what was reported in the nursing literature regarding the socio-demographic characteristics and the shortcomings RESPUESTAS - Año 12 No. 2 - Diciembre 2007 ISSN 0122820X of the ability of the care given. In the components that integrate the ability to take care of the patient such as knowledge, courage and patience, significant statistic differences were found between the two groups, reporting mayor levels of knowledge and patience among the family caretakers of the diabetes patients. Regarding the component of courage, there were no significant differences between the groups of the study.Key Words: Caretakers, Ability, Cerebrovascular Accident, Diabetes Mellitu
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Dissertations / Theses on the topic "Diabetes Mellitu"

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VIEIRA, Lindalva Layse de Lima Malagueta. "Estudo dos efeitos da Metformina na eletrogênese cardíaca." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/16255.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-04-01T12:26:27Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Doutorado. Tese de Lindalva Vieira. Ano 2015..pdf: 1577129 bytes, checksum: 08d435d57b1dfb816c8e6a8dcd551f50 (MD5)
Made available in DSpace on 2016-04-01T12:26:27Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Doutorado. Tese de Lindalva Vieira. Ano 2015..pdf: 1577129 bytes, checksum: 08d435d57b1dfb816c8e6a8dcd551f50 (MD5) Previous issue date: 2015-07-02
CAPEs
A Diabetes Mellitus (DM) é um grave problema de saúde pública, sendo uma das maiores causas de morbimortalidade na grande maioria dos países. Diferentes órgãos são acometidos pela DM; contudo, as doenças cardiovasculares são as maiores responsáveis pela elevada mortalidade vinculada à diabetes. A metformina é atualmente o principal fármaco utilizado para o tratamento da DM do tipo 2 (DM2), embora os riscos-benefícios cardiovasculares dessa droga não estejam totalmente elucidados. O presente estudo teve como objetivo avaliar o potencial arritmogênico da metformina em corações e cardiomiócitos de ratos saudáveis. No tratamento por 10 semanas com metformina os parâmetros biométricos e a glicemia plasmática não foram modificados, mas foi constatado um prolongamento dos intervalos PR, QT e QTc no eletrocardiograma, e uma redução da corrente transitória de saída de K+, Ito.Quando os cardiomiócitos foram incubados por 24 h com metformina, a amplitude da corrente Ito foi reduzida, enquanto aumentou a duração do potencial de ação cardíaco (DPA). A exposição de cardiomiócitos isolados à metformina por um período de 30 min, não reduziu a amplitude da corrente Ito, comprovando que a redução da corrente Ito em cardiomiócitos tratados por 10 semanas e incubados por 24 h com metformina, não ocorreu por uma ligação direta da droga ao canal. A corrente de cálcio tipo L (ICa-L) e a dependência de voltagem da inativação e recuperação da inativação da corrente Ito não foram afetadas em ambas as situações experimentais. Os níveis de RNAm que codifica as subunidades KV4.2, KV4.3 e KChIP2 do canal Ito não foram alterados, sugerindo que a redução da corrente Ito não ocorreria por uma menor síntese proteica das subunidades que compõem o canal Ito. Propõe-se que, esta redução seria resultante de uma acelerada degradação dos canais ou de uma deficiência funcional destes na membrana celular. A partir dos resultados obtidos na presente tese, conclui-se que a metformina apresenta potenciais efeitos arritmogênicos sobre o coração de animais saudáveis, capazes de levar eventualmente à morte súbita.
Diabetes Mellitus (DM) is a major public health problem, and is one of the biggest causes of morbidity and mortality in most countries. Many different human organs are affected by the DM, but cardiovascular diseases are the leading causes of mortality in patients with DM. Even today, the leading drug used to treat type-2 diabetes is metformin. However, its cardiovascular risk-benefits are not entirely clear. This study aimed to determine the potential arrhythmogenic effect of metformin in cardiomyocytes from healthy animals. Therefore, a 10 week treatment with metformin was performed, and it was proved that biometric and metabolic parameters were not affected. However, a lengthening of the PR, QT and QTc interval was found on the electrocardiogram, as well as a reduction in the output of the transitory potassium Ito current. When cardiomyocytes were incubated for 24 h with metformin, the amplitude of the Ito current was reduced and duration of cardiac action potential (APD) increased. Exposure of cardiomyocytes treated with metformin over a period of 30 min did not reduce the amplitude of the current Ito, demonstrating that the reduction in Ito current cardiomyocytes treated for 10 weeks and incubated for 24 h with metformin, does not occur by direct binding of the drug to the canal. The L-type calcium current (ICa-L) and the kinetic properties of voltage-dependent inactivation and recovery from inactivation of Ito current remained unchanged in both experimental conditions. RNAm levels of KV4.2, KChIP2 4.3 and Kv subunits remained unchanged. This suggests that the reduction of the Ito current may not be caused by a decrease in the protein synthesis subunit which is part of the Ito channel.Therefore, this reduction may be caused by a main degradation of the channels or by a worse operating performance in the cell membrane. Experiments accomplished during this thesis try to demonstrate that metformin causes arrhythmogenic effects in the heart of healthy animals.
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Jamali, Reza. "Peripheral Hypoglycaemic Neuropathy in Type 1 Diabetic Rats : Morphologic and Metabolic Studies." Doctoral thesis, Linköping : Univ, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7978.

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Fabris, Chiara. "Glucose variability assessment in diabetes mellitus monitoring and control." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424146.

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This dissertation is focused on the assessment of glucose variability (GV) in the treatment of the pathology of diabetes mellitus. GV is a risk factor for the development of diabetes complications, and its assessment combined with the evaluation of glycated hemoglobin levels is believed to be useful to characterize the functioning of glucose metabolism. Given the importance of GV in diabetes, a number of indicators to measure it from the retrospective analysis of sparse self-monitoring of blood glucose (SMBG) or continuous glucose monitoring (CGM) recordings have been proposed in the literature, but several issues are still open. For instance, some GV indicators have been developed specifically from SMBG data, and their use on CGM time-series has not been validated yet. Moreover, the availability of a large number of metrics to quantify GV gives rise to problems in terms of redundant conveyed information, and a compact way to extensively characterize GV would be desirable. Finally, the exploitation of CGM signals and GV to classify the metabolic condition of normal and diabetic subjects is a relatively unexplored problem that could deserve an investigation. These three topics are the object of this dissertation, which is specifically made up of six chapters whose content is briefly outlined below. Chapter 1 will describe the etiology of the different types of diabetes, discuss the development of diabetes complications, and introduce the technologies used to monitor blood glucose levels and the strategies exploited to manage the treatment of type 1 (T1DM) and type 2 (T2DM) diabetes mellitus. Chapter 2 will focus specifically on GV and its quantification, and, after highlighting the existing open issues, will precisely state the aims of the thesis. Chapter 3 will consider the problem of adapting some GV indicators originally developed and validated from SMBG, to the use with CGM signals. In particular, we will specifically look at low blood glucose index (LBGI) and high blood glucose index (HBGI), popular metrics that allow to provide a rapid classification of the quality of glucose control in diabetic subjects, and will provide alternate versions of these indicators adapted to the characteristics of CGMs by modeling the relationship between LBGI/HBGI values obtained from SMBG and CGM recordings. A dataset of 28 T1DM subjects monitored with both SMBG and CGM devices will be used to tune and assess the proposed methodology. Chapter 4 will address the issue of redundant information conveyed by the available GV indices by using the sparse principal component analysis (SPCA) technique as a tool to provide a parsimonious but still comprehensive characterization of GV in both T1DM and T2DM. Specifically, we will consider 25 GV indicators evaluated on CGM profiles acquired from 33 T1DM and 13 T2DM subjects as initial pool of variables. SPCA will be applied to this set of metrics and will be shown to be able to select a small subset of up to 10 indices that can save more than 60% of the original variance in both applications. The subset of metrics provided by SPCA can be used to parsimoniously describe GV in diabetes. Chapter 5 will be devoted to the assessment of the possibility of using the outputs from SPCA to build GV-based classifiers of the metabolic condition of normal and diabetic subjects. In particular, by resorting to a dataset of 55 T1DM subjects, 34 normal subjects at high risk of developing T2DM, 39 impaired glucose tolerance subjects, and 29 subjects with T2DM diagnosed, we will show that support vector machines are able to successfully classify the quality of glycemic control and the metabolic condition of disordered subjects, allowing to achieve an accuracy of classification always greater than 70%. The investigation will be performed using both the whole initial pool of 25 indicators and the parsimonious set selected by SPCA as features to design the classifiers; the fact that similar results were obtained in the two scenarios strengthens the speculation that the compact description of GV provided by SPCA is effectively comprehensive for characterizing the subjects' metabolic condition. Chapter 6 will close this dissertation, with a discussion on possible future developments of the presented investigations.
L'obiettivo di questa tesi è l'indagine del ruolo della variabilità glicemica (GV) nella patologia del diabete mellito. La GV è un fattore di rischio per lo sviluppo di complicazioni dal diabete, e la sua valutazione combinata con quella dei livelli di emoglobina glicata è ritenuta essere un elemento utile nel caratterizzare il funzionamento del metabolismo del glucosio. Data l'importanza della GV nel diabete, molteplici indicatori che permettono di ottenerne una quantificazione dall'analisi retrospettiva di segnali di self-monitoring of blood glucose (SMBG) o continuous glucose monitoring (CGM) sono stati proposti in letteratura, ma in merito esistono alcune problematiche ancora aperte. Per esempio, alcuni indici sono stati sviluppati specificamente per essere applicati su serie SMBG, ed il loro utilizzo su segnali CGM non è ancora stato validato. Inoltre, il fatto che esistano numerosi indicatori per quanticare la GV dà origine a problemi di ridondanza nell'informazione trasmessa, ed un approccio che permetta di ottenere una descrizione compatta ma esaustiva della GV sarebbe desiderabile. Infine, l'uso di segnali CGM e dell'informazione sulla GV per classificare lo stato metabolico di soggetti normali e diabetici è un problema relativamente inesplorato che potrebbe meritare di essere trattato. Questi tre argomenti sono l'oggetto di questa tesi, che risulta articolata in sei capitoli il cui contenuto è brevemente delineato di seguito. Il Capitolo 1 descriverà l'eziologia dei differenti tipi di diabete, discuterà lo sviluppo delle complicazioni da diabete, ed introdurrà le tecnologie utilizzate per monitorare la glicemia ed alcune strategie che si possono seguire per trattare il diabete mellito di tipo 1 (T1DM) e 2 (T2DM). Il Capitolo 2 verterà sulla GV e la sua quantificazione, e, dopo aver evidenziato i problemi aperti esistenti, dichiarerà precisamente gli scopi della tesi. Il Capitolo 3 considererà il problema di adattare alcuni indicatori di GV originariamente sviluppati e validati su profili SMBG, all'utilizzo su segnali CGM. In particolare, ci concentreremo su low blood glucose index (LBGI) e high blood glucose index (HBGI), indici popolari che permettono di ottenere una rapida classificazione della qualità del controllo glicemico in soggetti diabetici, e forniremo versioni alternative di questi indicatori adattate alle caratteristiche dei segnali CGM, modellando la relazione tra i valori che LBGI e HBGI assumono quando calcolati da SMBG e CGM. Un dataset di 28 soggetti T1DM monitorati con dispositivi SMBG e CGM sarà utilizzato per mettere a punto la metodologia. Il Capitolo 4 affronterà il problema della ridondanza nell'informazione fornita dagli indicatori di GV esistenti, utilizzando la sparse principal component analysis (SPCA) come approccio per fornire una descrizione parsimoniosa ma allo stesso tempo esaustiva della GV in popolazioni di soggetti con T1DM e T2DM. In particolare, considereremo 25 indicatori di GV valutati su profili CGM acquisiti da 33 soggetti con T1DM e 13 con T2DM come insieme iniziale di variabili. La SPCA sarà applicata a questo pool di indici e permetterà di selezionare un piccolo sottoinsieme di 10 indicatori che consente di preservare più del 60% della varianza originariamente spiegata dall'insieme di partenza in entrambe le applicazioni. Il sottoinsieme di indicatori fornito dalla SPCA può essere utilizzato per descrivere parsimoniosamente la GV nel diabete. Il Capitolo 5 sarà dedicato alla valutazione della possibilità di utilizzare gli output della SPCA per costruire classificatori dello stato metabolico di soggetti normali e diabetici basati sulla GV. In particolare, facendo ricorso ad un dataset di 55 soggetti con T1DM, 34 normali a rischio T2DM, 39 con impaired glucose tolerance, e 29 con T2DM diagnosticato, mostreremo che classificatori progettati su support vector machine sono capaci di discriminare con successo la qualità del controllo glicemico e la condizione metabolica di soggetti con disordini, permettendo di raggiungere un'accuratezza di classicazione sempre maggiore del 70%. Lo studio sarà condotto utilizzando sia il pool iniziale di 25 indicatori che il sottoinsieme parsimonioso fornito dalla SPCA come features per costruire i classificatori; il fatto che risultati simili siano ottenuti nei due casi rafforza la speculazione che la descrizione compatta della GV fornita dalla SPCA sia effettivamente esaustiva nel caratterizzare la condizione metabolica dei soggetti. Il Capitolo 6 chiuderà la tesi, con una discussione su possibili sviluppi futuri degli studi qui presentati.
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GRANCINI, VALERIA. "RUOLO CENTRALE DELLA BETA-CELLULA NEL PROMUOVERE LA REGRESSIONE DEL DIABETE DOPO TRAPIANTO DI FEGATO IN PAZIENTI CON CIRROSI EPATICA." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/658515.

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BACKGROUND & AIMS: Diabetes occurring as a direct consequence of loss of liver function is usually characterized by non-diabetic fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) levels and should regress after orthotopic liver transplantation (OLT). This observational, longitudinal study investigated the relationship between the time-courses of changes in all 3 direct determinants of glucose regulation, i.e., β-cell function, insulin clearance and insulin sensitivity, and diabetes regression after OLT. METHODS: Eighty cirrhotic patients with non-diabetic FPG and HbA1c levels underwent an extended oral glucose tolerance test (OGTT) before and 3, 6, 12 and 24 months after OLT. The OGTT data were analysed with a mathematical model to estimate derivative control (DC) and proportional control (PC) of β-cell function and insulin clearance (which determine insulin bioavailability), and with the Oral Glucose Insulin Sensitivity (OGIS)-2 h index to estimate insulin sensitivity. RESULTS: At baseline, 36 patients were diabetic (45%) and 44 were non-diabetic (55%). Over the 2-year follow-up, 23 diabetic patients (63.9%) regressed to non-diabetic glucose regulation, whereas 13 did not (36.1%); moreover, 4 non-diabetic individuals progressed to diabetes (9.1%), whereas 40 did not (90.9%). Both DC and PC increased in regressors (from month 3 and 24, respectively) and decreased in progressors, whereas they remained stable in non-regressors and only PC decreased in non-progressors. Insulin clearance increased in all groups, apart from progressors. Likewise, OGIS-2 h improved at month 3 in all groups, but thereafter it continued to improve only in regressors, whereas it returned to baseline values in the other groups. CONCLUSIONS: Increased insulin bioavailability driven by improved β-cell function plays a central role in favouring diabetes regression after OLT, in the presence of a sustained improvement of insulin sensitivity.
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Rossetti, L. "PLATELET ACTIVATION AND ASSOCIATED TRANSCRIPTIONAL SIGNATURE IN TYPE 2 DIABETIC PATIENTS WITH STABLE CORONARY ARTERY DISEASE: INSIGHTS INTO THEIR THROMBOTIC PROPENSITY." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/246942.

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Platelet activation and associated transcriptional signature in type 2 diabetic patients with stable coronary artery disease: insights into their thrombotic propensity Several studies indicate that despite aspirin therapy patients with type-2 diabetes mellitus (T2DM) have both an enhanced platelet reactivity and a hypercoagulable state, supporting the evidence of a greater incidence of coronary artery disease (CAD) compared to patients without T2DM. Tissue Factor (TF) is the principal activator of blood coagulation; it is also expressed by platelets, which, upon activation translocate the protein on the cell surface. We have previously shown that platelet-associated TF (pTF) is increased in CAD patients compared to healthy subjects contributing to an increased thrombin generation capacity. No information is still available on pTF expression in diabetic patients with stable angina (SA). Our aim is to provide insight into the enhanced risk of thrombotic complications associated with T2DM in order to clarify pathways altered by diabetes and to find new potential targets of pharmacological modulation. In this study we assessed whether T2DM affects pTF expression, the overall prothrombotic potential and platelet transcriptome profile in patients with SA. We enrolled 85 patients with stable angina (SA), 32 with T2DM and 53 without T2DM; 28 diabetic patients without SA and 37 healthy subjects (HS). Assessment of surface and intracytoplasmic pTF expression was performed by whole blood flow cytometry. The prothrombotic potential was analyzed by thrombin generation assay both in plasma and in isolated platelets using Thrombinoscope. The global haemostatic function was evaluated by thromboelastometry (Rotem). Platelet transcriptome profiles were studied using Illumina BeadChip Human HT-12 v4 microarray. Haematologic parameters were comparable among the 4 groups except for the percentage of immature platelet fraction, which was higher in SA patients with T2DM (p<0.05). T2DM was associated with an increase in TF expression on platelet surface: it was significantly increased in SA patients with T2DM compared to SA without T2DM and HS (p<0.05). Moreover a significantly higher number of intracytoplasmic TF+-platelets was found in SA patients with T2DM compared to patients without T2DM (27.53±2.8 vs. 14.98±1,34, p<0,001). This finding resulted in an increased thrombin generation, being shorter both the lag time and the time to peak in T2DM patients. TF contribution to thrombin generation was assessed treating samples with an anti-TF antibody which resulted in an increase in the time needed to start thrombin generation in both group of patients, and the delay was significantly greater in diabetic patients. Maximum Clot Firmness, α-Angle and Maximum Velocity of clot formation assessed by ROTEM were all significantly increased in diabetic patients. Microarray analysis showed that 319 unique mRNAs that were differentially expressed between SA patients and HS. When comparison of platelet gene profiling was performed between SA patients with or without T2DM, only 35 genes were found differently expressed. The most upregulated transcript in SA patients with T2DM was CD69, which was reported to be involved in thromboxane production and platelet aggregation. In conclusion the data here provided indicate that SA patients with T2DM are characterized by a higher number of circulating TF+-platelets compared to patients without T2DM. The platelet-associated TF is functionally active, being able to trigger thrombin generation, which is blocked by a specific anti TF antibody. These findings shed new light on the mechanism involved in the enhanced prothrombotic phenotype associated with T2DM. The differentially expressed transcripts in T2DM platelets provide new insights into the mechanisms underlying the increased platelet reactivity which will be further explored by ad hoc studies.
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GIULIANI, ANGELICA. "Role of microRNAs in inflammaging and age related diseases." Doctoral thesis, Università Politecnica delle Marche, 2018. http://hdl.handle.net/11566/253098.

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L’invecchiamento è un complesso processo derivante da una combinazione di fattori ambientali, genetici e stocastici, caratterizzato da uno stato proinfiammatorio. Questa infiammazione cronica. Di basso grado e sistemica è stata recentemente teorizzata e definita col termine “inflammaging” e rappresenta uno dei principali fattori di rischio di patologie - e.g. patologie cardiovascolari, diabete mellito di tipo 2 e patologie neurodegenerative – comunemente chiamate patologie età-correlate (ARDs). La senescenza cellulare è storicamente associata all’invecchiamento. La senescenza può essere definita come un arresto stabile del ciclo cellulare accompagnato da una varietà di alterazioni molecolari e biochimiche – e.g. attività metabolica, profilo epigenetico, pathways apoptotici e l’acquisizione di un fenotipo secretorio associato alla senescenza (SASP). Attraverso l’acquisizione del fenotipo SASP, le cellule senescenti sono in grado di modificare il microambiente e alimentare uno stato di infiammazione cronica. I meccanismi che stanno alla base di questi processi infiammatori rappresentano un tema all’avanguardia nel campo della gerontologia molecolare. I microRNA sono regolatori versatile dell’espressione genica e l’identificazione di un vasto repertorio di queste molecole nel genoma dei mammiferi ha completamente rivoluzionato la nostra comprensione della maggior parte dei processi biologici. Recentemente, il nostro gruppo di ricerca ha contribuito all’identificazione di un piccolo sottogruppo di microRNA (SA-inflamma-miR) modulati e. a loro volta. regolatori della senescenza cellulare, dell’iflammaging e delle ARDs. Abbiamo esplorato tre diversi nuovi aspetti degli SA-inflamma-miR: i) la loro regolazione nelle funzioni mitocondriali nella senescenza replicativa delle cellule endoteliali; ii) la loro modulazione e risposta a seguito del trattamento delle cellule endoteliali con l’adalimumab, un anticorpo monoclonale diretto contro il fattore di necrosi tumorale-α (TNF-α), componente principale della SASP; iii) la loro rilevanza diagnostica in una vasta coorte di soggetti sani di diversa età e pazienti affetti da diabete di tipo 2.
Aging is a complex process that results from a combination of environmental, genetic, epigenetic, and stochastic factors. A proinflammatory status is a pervasive feature of aging. This chronic, low-grade, and systemic inflammation has been defined as "inflammaging” and represents one of the major risk factor for pathologies such as cardiovascular diseases, T2DM, and neurodegenerative diseases – commonly referred to as “age-related diseases” (ARDs). Cellular senescence is historically associated with aging. Senescence can be defined as a stable arrest of the cell cycle coupled with a plethora of alterations, e.g. metabolic activity, epigenetic status, apoptosis pathways, and expression of a senescence associated (SA) secretory phenotype (SASP). Through acquisition of the SASP, senescent cells can modify the tissue microenvironment and fuel chronic inflammation, thus promoting the aging process and ARDs development. The mechanisms underlying this inflammatory process represent a cutting-edge topic in the field of molecular gerontology. MiRNAs are versatile regulators of gene expression and the identification of a vast repertoire of miRNA in the mammalian genome has completely revolutionized our understanding of most biological processes. Recently, our group has provided evidence that a relatively small packet of miRNAs, namely SA-inflamma-miRs are regulated by and can in turn affect the senescence process, inflammaging, and ARDs development. Here we explored 3 novel features of SA-inflamma-miRs : i) their regulation of mitochondrial functions during replicative senescence of endothelial cells; ii) their modulation and responsiveness following endothelial cells treatment with adalimumab, a monoclonal antibody directed against tumor necrosis factor-α (TNF-α), a major SASP component; iii) their diagnostic relevance in a large cohort composed of healthy subjects with different age and patients affected by type 2 diabetes, a prototypical ARD.
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Radzevičienė, Lina. "Sergančiųjų cukriniu diabetu mokymo organizavimo ir kokybės vertinimas poliklinikoje." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060612_144532-92108.

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Aim of the study. To assess the organization possibilities and evaluate the quality of diabetes education in outpatient clinic. Methods. The anonymous questionnaire survey was performed among adult diabetic patients in Kaunas Dainava outpatient clinic in october-December, 2005. 500 questionnaire were given to the patients, the responce rate was 354 patients (70.8 %). The data was analysed by application of statistical package SPSS 12.0 for Windows. The associations between the variables were measured using the Chi-squared (χ²) test. Results. The positive evaluation of diabetes education in Kaunas Dainava outpatient clinic was given by 73.7 % of patients. 98.3 % believed that diabetes education is necessary. 77.9 % knew about diabetes, 80.8 % - were aware of fasting glycaemia criteria, 95.3 % - glycaemia in untreated patients. 82.2 % understood the importance of diet and it‘s ingredients (90.6 %). Less than a half (40.4 %) were aware of glycated hemoglobin and importance of postprandial glycaemia. Only 33.2 % of those taught in „Diabetes school“ had adequate diabetes control. The target glycated hemoglobin was reached in 42.1 % of thosewho attended the inpatient „Diabetes school“ and only in 22.5 % of those who didn‘t. Diabetes complications have been diagnosed in 43.7 % of those whose glycated hemoglobin ≤ 7 % and in 76.2 % of those whose glycated hemoglobin > 7 %. Conclusions. Diabetes education in Kaunas Dainava outpatient clinic is not sistematic organized, the time of... [to full text]
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Beales, Philip Edward. "Diabetes prevention in the non-obese diabetic mouse." Thesis, University of East London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265059.

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Nordwall, Maria. "Long term complications in juvenile diabetes mellitus." Doctoral thesis, Linköping : Univ, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-6377.

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COSENTINO, NICOLA. "EFFECTS OF STRESS HYPERGLYCEMIA ACCORDING TO DIABETICSTATUS IN PATIENTS WITH ST-ELEVATION MYOCARDIALINFARCTION AND ITS RELATIONSHIP WITH CARDIAC CELL INJURYAND MITOCHONDRIAL DAMAGE: A TRANSLATIONAL APPROACH." Doctoral thesis, Università degli Studi di Milano, 2023. https://hdl.handle.net/2434/946992.

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Background: Acute hyperglycemia (AH) is common in ST-elevation myocardial infarction (STEMI) and predicts outcomes. AH is a more powerful prognostic predictor in patients without diabetes mellitus (DM) than with DM, emphasizing the role of an acute glucose rise compared to chronic elevations. Moreover, AH may exacerbate, thorough mitochondrial dysfunction, infarct size (IS). We investigated the association between AH and chronic glycemia, considered separately or in combination, with mitochondrial injury and myocardial IS in STEMI patients with or without DM. Methods: We measured admission serum glucose (AH), cytochrome c and mitochondrial DNA levels (mitochondrial biomarkers), and estimated chronic glucose in all patients. We calculated the acute on chronic (A/C) glycemic ratio. The primary endpoint was IS at cardiac magnetic resonance. The composite of in hospital mortality, acute-pulmonary-edema, and shock was the secondary endpoint. Results: 100 STEMI patients with DM and 100 without were included. IS was 25gr and 19gr and the secondary endpoint occurred in 21% and 8% of patients with and without DM, respectively (p=0.02 and p=0.01, respectively). The A/C ratio only significantly correlated with cytochrome c and mitochondrial DNA levels in DM patients. However, at reclassification analyses, A/C glycemic ratio showed the best prognostic power in predicting the primary and secondary endpoints as compared to AH in DM (net-reclassification-index 28% and 31%, respectively) but not in non DM patients (net-reclassification-index 1% and 2%, respectively). In DM patients, A/C glycemic ratio, but not AH, significantly predicted 1-year mortality, after adjustment for major confounders. 4 Conclusions: In STEMI patients with DM, A/C glycemic ratio seems to be a better predictor of IS and in-hospital and 1-year outcome than AH. This study highlights the prognostic role of A/C ratio, its impact on mitochondrial impairment and outcomes, and may pave the way to interventional trials targeting AH according to A/C ratio in DM patients with STEMI.
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Books on the topic "Diabetes Mellitu"

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Olson, O. Charles. Diagnosis and management of diabetes mellitus. 2nd ed. New York: Raven Press, 1988.

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Marewa, Lukman Waris. Kencing manis (diabetes mellitus) di Sulawesi Selatan. Jakarta: Yayasan Pustaka Obor Indonesia, 2015.

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1937-, Brenner Barry M., and Stein Jay H. 1937-, eds. The Kidney in diabetes mellitus. New York: Churchill Livingstone, 1989.

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1959-, Frost Gary, Dornhorst Anne, and Moses Robert 1946-, eds. Nutritional management of diabetes mellitus. Chichester: John Wiley & Sons, 2003.

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Albert, Reece E., and Coustan Donald R, eds. Diabetes mellitus in pregnancy. 2nd ed. New York: Churchill Livingstone, 1995.

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Lippincott Williams & Wilkins., ed. Diabetes mellitus: A guide to patient care. Philadelphia: Lippincott Williams & Wilkins, 2007.

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�zcan, Sabire. Diabetes Mellitus. New Jersey: Humana Press, 2003. http://dx.doi.org/10.1385/1592593771.

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Nakabeppu, Yusaku, and Toshiharu Ninomiya, eds. Diabetes Mellitus. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-3540-2.

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Bibergeil, Horst, ed. Diabetes mellitus. Vienna: Springer Vienna, 1989. http://dx.doi.org/10.1007/978-3-7091-7562-0.

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Bretzel, Reinhard G., ed. Diabetes mellitus. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-74610-9.

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Book chapters on the topic "Diabetes Mellitu"

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Sen, Saikat, Raja Chakraborty, and Biplab De. "Biomarkers of Diabetes and Diabetic Complications." In Diabetes Mellitus in 21st Century, 101–24. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-1542-7_9.

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Hahn, H. J. "Tierexperimenteller Diabetes." In Diabetes mellitus, 108–17. Vienna: Springer Vienna, 1989. http://dx.doi.org/10.1007/978-3-7091-7562-0_4.

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Köhler, Erika. "Biochemie und Pathobiochemie des Kohlenhydrat-Stoffwechsels — Verknüpfung mit dem Gesamtstoffwechsel." In Diabetes mellitus, 21–37. Vienna: Springer Vienna, 1989. http://dx.doi.org/10.1007/978-3-7091-7562-0_1.

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Standl, E., and H. U. Janka. "Diabetes mellitus und Gefäßkrankheiten — Gesamtschau." In Diabetes mellitus, 437–68. Vienna: Springer Vienna, 1989. http://dx.doi.org/10.1007/978-3-7091-7562-0_10.

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Gliem, H. "Diabetes und Auge." In Diabetes mellitus, 469–85. Vienna: Springer Vienna, 1989. http://dx.doi.org/10.1007/978-3-7091-7562-0_11.

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Schulz, B. "Diabetes und Niere." In Diabetes mellitus, 486–500. Vienna: Springer Vienna, 1989. http://dx.doi.org/10.1007/978-3-7091-7562-0_12.

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Schulz, B. "Diabetes und Herz." In Diabetes mellitus, 501–7. Vienna: Springer Vienna, 1989. http://dx.doi.org/10.1007/978-3-7091-7562-0_13.

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Schulz, B. "Diabetes und Hypertonus." In Diabetes mellitus, 508–12. Vienna: Springer Vienna, 1989. http://dx.doi.org/10.1007/978-3-7091-7562-0_14.

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Reichel, G. "Diabetes und Nerv." In Diabetes mellitus, 513–36. Vienna: Springer Vienna, 1989. http://dx.doi.org/10.1007/978-3-7091-7562-0_15.

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Beckert, R. "Der diabetische Fuß." In Diabetes mellitus, 537–52. Vienna: Springer Vienna, 1989. http://dx.doi.org/10.1007/978-3-7091-7562-0_16.

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Conference papers on the topic "Diabetes Mellitu"

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Elcin, Huseyn. "EARLY IDENTIFICATION OF THE NEUROLOGICAL COMPLICATIONS OF DIABETES MELLITUS." In International Trends in Science and Technology. RS Global Sp. z O.O., 2021. http://dx.doi.org/10.31435/rsglobal_conf/30032021/7474.

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Diabetes mellitus is still a very common disease in the world and affects the daily lives of patients negatively. Diabetes is also known to be associated with neurological diseases such as peripheral nerve diseases, stroke and dementia. Among these, the most common disease is a peripheral nerve disease, and it has been reported that poor diabetic control increases the risk of development and can be prevented by education of the patients. Vascular dementia is more common in patients with diabetes than Alzheimer's disease, and it is thought that cerebrovascular diseases may berelated to cognitive impairment in diabetes. Although the mechanisms by which diabetes affects the brain are not clearly revealed, it is thought that changes in vascular structure, insulin resistance, glucose toxicity, oxidative stress, accumulation of glycation end products, hypoglycemic episodes and amyloid metabolism are effective.The aim of this article is to describe the neurological complications of diabetes and to emphasize the importance of patient education, good diabetes control and early diagnosis in preventing these complications.
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Montani, N., S. B. Solerte, G. Gamba, M. Fioravanti, and E. Ferrari. "RELATIONSHIPS BETWEEN HAEMOSTATIC ENDOTHELIAL FUNCTIONS AND GLOMERULAR FILTRATION RATE IN SHORT-TERM TYPE I DIABETES MELLITUS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643101.

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It is known that the increase of glomerular filtration rate (GFR) represents an early sign of diabetic nephropathy. The changes of endothelial functions observed in diabetes might play a role in this respect. As F VIII vWF and fibronectin are synthetized by endothelial cells, we evaluated these components in 33 diabetic patients with short-term Type I (insulin dependent) diabetes mellitus, without retinopathy and macro-vascular complications. 15 pts. (mean age 29 ± 7 yrs; mean diabetes duration 2.9 ± 0.9 yrs) presented high GFR (154 ± 19 ml/min per 1.73 m2 ; albuminuria 7.2 ± 3.2 μg/min) and 18 pts. (mean age 30 ± 6 yrs; mean diabetes duration 3.0 ± 1 yrs) normal GFR (105 ± 11 ml/min per 1.73 m2 ; albuminuria 5 ± 2.8 μg/min).The following results were obtained:In conclusion the significant increase of FVIIIR:Ag and fibronectin levels in short-time type I diabetic patients with high GFR suggests an early endothelial cell function damage also related to the Door metabolic control.
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Nugroho, Trilaksana, Hari Peni Julianti, Arief Wildan, rnila Novitasari Saubig, Andhika Guna Darma, and Desti Putri Seyorini. "Risk Factor of Dry Eyes Syndrome Toward Elderly with Diabetes Mellitus." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.26.

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ABSTRACT Background: Chronic metabolic disorder diabetes is a rapidly developing global problem with huge social, health and economic consequences. Indonesia is expected to reach 21.3 million people by 2030, and the incidence of diabetes is still increasing. Type 2 diabetes (T2DM) is an expanding global health problem closely related to the obesity epidemic. Type 2 diabetes (T2DM) is an expanding global health problem closely related to the obesity epidemic. Prolonged diabetes mellitus (DM) causes autonomic neuropathy in the lacrimal glands, which leads to reduced tear production, leading to dry eye syndrome (DES). This study aimed to analyze risk factor of dry eyes syndrome toward elderly with diabetes mellitus. Subjects and Method: A cross sectional study was conducted at community health center Gunungpati and Graha Syifa clinic, Semarang. A sample of 28 elderlies was selected by consecutive sampling. The dependent variable was incidence of DES. The independent variables were gender, duration of DM, DM control, incidence of diabetic retinopathy, type of work, exposure to cigarette smoke, exposure to gadgets, incidence of hypertension, incidence of dyslipidemia, incidence of cataracts. The data were collected by examination, questionnaire and in-depth interview. The data were analyzed by logistic regression and Chi square. Results: The logistic regression test results showed that gender, (p = 0.393), duration of diabetes (p = 0.208), and the incidence of diabetic retinopathy (p = 0.264) were not risk factors for DES. The results of the logistic regression test showed that controlling diabetes (p = 0.002), gadget exposure (p = 0.023) were risk factors for DES incidence. DM control and gadget exposure contributed 75% as risk factors for DES events. Conclusion: Uncontrolled DM and exposure to gadgets> 2 hours continuously a day are risk factors for DES. Keywords: Dry eyes, Diabetes Mellitus, Elderly Correspondence: Trilaksana Nugroho. Faculty of Medicine, Universitas Diponegoro. Jl. Prof. Sudarto No.13, Tembalang, Kec. Tembalang, Kota Semarang, Jawa Tengah 50275. DOI: https://doi.org/10.26911/the7thicph.05.26
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Aprilia, Dinda, Eva Decroli, Alexander Kam, Afdol Rahmadi, Asman Manaf, and Syafril Syahbuddin. "Sepsis in Type 1 Diabetes Mellitus with Diabetic Ketoacidosis." In The 2nd International Conference on Tropical Medicine and Infectious Disease. SCITEPRESS - Science and Technology Publications, 2019. http://dx.doi.org/10.5220/0009859200720074.

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Ammutammima, Ummu Fatihah, Didik Gunawan Tamtomo, and Bhisma Murti. "Family History with Diabetes Mellitus and the Gestational Diabetes Mellitus: Meta-Analysis." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.54.

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Background: Gestational diabetes mellitus (GDM) is a major public health problem because of its associated complications during pregnancy. Studies have suggested that women with positive parental history of diabetes may be predisposed to an increased GDM risk. This study aimed to examine the correlation between family history with diabetes mellitus and the gestational diabetes mellitus. Subjects and Method: This was a meta-analysis and systematic review. The study was collected articles from PubMed, Science Direct, and Google Scholar databases, from year 2017 to 2020. Keywords used “gestational diabetes mellitus” OR “GDM” AND “pregnancy induced diabetes” AND “family history of diabetes” AND “crosssectional”. The study subject was pregnant women. Intervention was family history with diabetes mellitus with comparison no family history of diabetes mellitus. The study outcome was gestational diabetes mellitus. The articles were selected by PRISMA flow chart. The quantitative data were analyzed by ReVman 5.3. Results: 7 studies from Kuwait, Ethiopia, Fiji, Malaysia, and China, reported that family history with diabetes mellitus increased the risk of gestational diabetes mellitus (aOR= 1.68; 95% CI= 0.87 to 3.26; p= 0.120). Conclusion: Family history with diabetes mellitus increases the risk of gestational diabetes mellitus. Keywords: gestational diabetes mellitus, pregnancy induced diabetes, family history of diabetes Correspondence: Ummu Fsatihah Ammutammima. Masters Program Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: ummuftha64@gmail.com. Mobile: 081717252573. DOI: https://doi.org/10.26911/the7thicph.05.54
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Sitorukmi, Galuh, Bhisma Murti, and Yulia Lanti Retno Dewi. "Effect of Family History with Diabetes Mellitus on the Risk of Gestational Diabetes Mellitus: A Meta-Analysis." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.55.

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Background: Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women without previously diagnosed diabetes develop chronic hyperglycemia during gestation. Studies have revealed that the family history of diabetes is an important risk factor for the gestational diabetes mellitus. The purpose of this study was to investigate effect of family history with diabetes mellitus on the risk of gestational diabetes mellitus. Subjects and Method: This was meta-analysis and systematic review. The study was conducted by collecting published articles from Pubmed, Google Scholar, Scopus, Science Direct, and Springer Link electronic databases, from year 2010 to 2020. Keywords used risk factor, gestational diabetes mellitus, family history, and cross-sectional. The inclusion criteria were full text, using English language, using cross-sectional study design, and reporting adjusted odds ratio. The study population was pregnant women. Intervention was family history of diabetes mellitus with comparison no family history of diabetes mellitus. The study outcome was gestational diabetes mellitus. The collected articles were selected by PRISMA flow chart. The quantitative data were analyzed by random effect model using Revman 5.3. Results: 7 studies from Ethiopia, Malaysia, Philippines, Peru, Australia, and Tanzania were selected for this study. This study reported that family history of diabetes mellitus increased the risk of gestational diabetes mellitus 2.91 times than without family history (aOR= 2.91; 95% CI= 2.08 to 4.08; p<0.001). Conclusion: Family history of diabetes mellitus increases the risk of gestational diabetes mellitus. Keywords: gestational diabetes mellitus, diabetes mellitus, family history Correspondence: Galuh Sitorukmi. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: galuh.sitorukmi1210@gmail.com. Mobile: 085799333013. DOI: https://doi.org/10.26911/the7thicph.05.55
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Septiani, Anissa Eka, Bhisma Murti, Setyo Sri Rahardjo, and Hanung Prasetya. "Meta-Anaylsis: Gender and the Risk of Lower Extremity Amputation in Patients with Type 2 Diabetes Mellitus and Foot Ulcer." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.01.37.

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ABSTRACT Background: Diabetes is an independent predictor of limb amputation (versus revascularization) for the treatment of critical limb ischemia. Much of the cost related to diabetes results from macrovascular and microvascular complications, such as myocardial infarctions, end-stage renal disease, and lower extremity amputations (LEAs). This study aimed to examine the associations between gender and the risk of lower extremity amputation in patients with type 2 diabetes mellitus and foot ulcer. Subjects and Method: A meta-analysis and systematic review was conducted by collected published articles from Pubmed, Scopus, Google Scholar, and Springer Link databases. Lower limb amputation, lower extremity amputation, diabetic foot, and diabetic ulcer keywords were used to collect the articles. The inclusion criteria were full text, cohort study, and reporting adjusted odds ratio. The selected articles were analyzed by PRISMA flow chart and revman 5.3. Results: 9 articles were reported that male increased the risk of lower extremity amputation in type 2 DM patients (aOR= 1.60; 95% CI= 1.32 to 1.94; p<0.001). Conclusion: Male increases the risk of lower extremity amputation in type 2 DM patients. Keywords: lower extremity amputation, type 2 diabetes mellitus, foot ulcer Correspondence: Anissa Eka Septiani. Masters Program in Public Heath, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: sanissaeka@gmail.com. Mobile: 089514646458. DOI: https://doi.org/10.26911/the7thicph.01.37
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Nievelstein, P. F. E. M., J. D. Banga, M. Ottenhof-Rovers, J. J. Zwaginga, P. G. de Groot, and J. J. Sixma. "ADHESION OF BLOOD PLATELETS FROM PATIENTS WITH DIABETES MELLITUS TYPE I, TO THE ENDOTHELIAL CELL MATRIX OF HUMAN VASCULAR ENDOTHELIAL CELLS, UNDER FLOW CONDITIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643105.

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Platelet activation in diabetes mellitus may precede vasculopathy. We have studied platelet adhesion and thrombus formation in flowing blood of diabetic patients without macro-and microvascular complications. Platelet function and release, bleeding time, fibrinogen, FVIII:RAg, Ri:Co, Triglycerides, Cholesterol and HDL Cholesterol levels, Apo A, Apo B and TK values were in the normal range. Glucose levels and HBA1 were increased. The matrix of cultured human umbilical vein endothelial cells (ECM) was used for adhesion studies.In an adhesion model with citrated blood (3.1%) and an untreated ECM, three male and three female diabetics (mean age 29.6 y., range 20-32 y., average duration of diabetes 10.6 y., range 2-23 y.) were compared with six age and sex-matched corf-trols. No differences in platelet coverage (en face) was obtained at low (300 s™1 ) and high (1300 s™1 ) wall shear rates, and the time dependence (1-20 min) was the same.We also used a thrombosis model, consisting of the matrix of PMA-treated endothelial cells which induces tissue factor production, perfused with blood anticoagulated with low molecular weight heparin, which does not inhibit local thrombus formation. Four male and two female patients (mean age 25.4 y., range 22-40 y., average duration of diabetes 10 y., range 2-28 y.) were compared with six age and sex matched controls. Cross sections showed equal total adhesion at 300 s™1 and 1300 s™1 after 1, 3, 5 or 10 minutes perfusion. In the diabetics, spread platelets were significantly decreased at 300 s™1 after 1 and 3 min, and at 1300 s™1 after 5 min; small aggregates (< 5μM) were increased after 1 min at 300 s™1 . At 300 s™1 some patients (2 of 6) showed a faster and more extensive fibrin formation.We conclude that _ in this group of diabetics there is no difference in primary adhesion but that there is an enhanced tendency in thrombus formation and fibrin deposition.
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SCISLOWSKI, LETICIA AUDA, MARIA LUIZA MENDES, and PEDRO HENRIQUE NAVARRO XAVIER. "HEPATITE C E DIABETES MELLITUS: UMA BREVE REVISÃO DE LITERATURA." In I Congresso Brasileiro On-line Multiprofissional de Análises Clínicas e Laboratoriais. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/conalab/7676.

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Introdução: a Hepatite C é uma doença infectocontagiosa transmitida pelo vírus HCV. Algumas complicações podem ser correlacionadas com essa infecção, entre estas há prevalência da Diabetes Mellitus tipo 2 como uma forma extra-hepática. Apesar de o mecanismo não ser completamente conhecido este tipo de diabetes pode se apresentar como uma forma crônica da infecção, pois o vírus HCV pode atuar como um fator importante na instalação desta complicação em indivíduos que apresentam fatores de risco. Objetivos: o presente resumo tem como objetivo apresentar a comunidade acadêmica a correlação da doença infecciosa HCV com a manifestação clinica da Diabete Mellitus do tipo 2. Metodologia: este estudo foi realizado por meio de revisão bibliográfica utilizando artigos científicos publicados nas seguintes plataformas PubMed, Scielo, Google Acadêmico, entre outras, foram empregados os seguintes termos: Hepatite C, Hepatite C e Diabetes, Hepatite C e resistência a insulina. Resultados: estudos demonstraram uma taxa maior de portadores de hepatite C no grupo de pacientes que apresentavam diabetes do tipo 2 em relação aos que apresentavam diabetes do tipo 1, sendo respectivamente 2% de infectados para 0%. Em comparação a pacientes não diabéticos o resultado foi de 0,65%, demonstrando assim uma maior prevalência da hepatite C em pacientes que apresentam a diabetes do tipo 2. Sendo que após o tratamento do HCV ocorre uma forte redução da incidência da DM2. Outros estudos não revelam diferença significativa na infecção nos grupo de diabéticos e não diabéticos, tendo demonstrado percentual de 1,4% de infectados no grupo de diabéticos e 1% no grupo de não diabéticos. O HCV gera diversos distúrbios metabólicos que quando combinados com fatores externos podem agravar os mecanismos de resistência a insulina em pacientes predispostos, levando possivelmente ao desenvolvimento da DM2. Conclusão: embora o mecanismo não seja totalmente conhecido, observa-se que a infecção por esse vírus pode contribuir para o surgimento da doença diabética, isso em indivíduos que possuem predisposição ou presença de outros fatores como obesidade e sedentarismo.
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Sandbjerg Hansen, M., and B. Milner Jørgensen. "FUNCTIONAL CHANGES IN ANTITHROMBIN III IN INSULIN-DEPENDENT DIABETES MELLITUS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643104.

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The thrombin neutralizing activity of Antithrombin III (AT) was measured in a group of patients with insulin-dependent diabetes mellitus. All patients evaluated had diabetes of several years duration. Their blood glucose control was unsatisfactory as evidenced by relative concentrations of glycated hemoglobin (HbA1c) of 9.6-14.0% determined by polyacrylamide gel electrophoresis. The plasma AT-activity was estimated as thrombin neutralizing activity using the chromogenic substrate Th-1.The group of diabetic patients had a higher AT-activity than a reference group, but normal AT-concentrations by electro-immunoassay. The treatment of the patient samples with neuraminidase caused a greater fall in the AT-activity than did the treatment of normal samples. The patient samples had a slower mobility in crossed affino-immunoelectrophoresis using immobilized helix pomatia lectin in the first dimension and specific antibodies against AT in the second dimension. The mobility of patient AT, also in complex with thrombin, was indistinguishable from normal AT in crossed immunoelectrophoresis in the presence or absence of heparin.It is concluded that long-term dysregulation of diabetes mellitus may induce functional changes in the plasma antithrombin activity.
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Reports on the topic "Diabetes Mellitu"

1

Deo, Salil, David McAllister, Naveed Sattar, and Jill Pell. The time-varying cardiovascular benefits of glucagon like peptide-1 agonist (GLP-RA)therapy in patients with type 2 diabetes mellitus: A meta-analysis of multinational randomized trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2021. http://dx.doi.org/10.37766/inplasy2021.7.0097.

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Review question / Objective: P - patients with type 2 diabetes melllitus already receiving routine medical therapy; I - patients receiving glucagon like peptide 1 receptor agonist (GLP1 receptor agonist) therapy (semaglutide, dulaglutide, liraglutide, exenatide, lixisenatide, efpeglenatide, abiglutide); C - patients receiving standard therapy for diabetes mellitus but not receiving GLP1 agonist therapy; O - composite end point as per invididual trial, cardiovascular mortality, all-cause mortality, myocardial infarction, stoke. Condition being studied: Type 2 diabetes mellitus. Study designs to be included: Randomised controlled trials which enroll a large number of patients (defined as > 500) and are multinational in origin. Studies included will need to have published Kaplan and Meier curves for the end-points presented in the manuscript.
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Pillay, Jennifer, Pritam Chordiya, Sanjaya Dhakal, Ben Vandermeer, Lisa Hartling, Marni J. Armstrong, Sonia Butalia, et al. Behavioral Programs for Diabetes Mellitus. Agency for Healthcare Research and Quality, September 2015. http://dx.doi.org/10.23970/ahrqepcerta221.

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Wang, Wei, and Yi Wu. Prediction models for diabetic retinopathy development in type 2 diabetes mellitus patients: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0089.

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Fu, Shouqiang, Liwei Zhang, Xiaoyun Zhu, and Ximing Liu. Associating Abdominal Obesity with Diabetic Retinopathy in Patients with Diabetes Mellitus: Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0091.

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Lekhanya, Portia Keabetswe, and Kabelo Mokgalaboni. Exploring the effectiveness of vitamin B12 complex and alpha-lipoic acid as a treatment for diabetic neuropathy. Protocol for systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0167.

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Review question / Objective: Does Alpha-Lipoic acid increase the uptake of glucose for better glycaemic control? Does vitamin B12 and Alpha-Lipoic acid improve inflammation? The aim of the study is to explore the effectiveness of Vitamin B12 and Alpha-Lipoic Acid as a possible treatment for diabetic neuropathy with major emphasis on markers of inflammation and glucose metabolism. Condition being studied: Diabetic Neuropathy (DN) is a heterogeneous type of nerve damage associated with diabetes mellitus, the condition most often damages nerves in the legs and feet. It presents both clinically and sub-clinically affecting the peripheral nervous system as a result of an increase in glucose concentration which interferes with nerve signalling. After the discovery of insulin as a treatment for Diabetes Mellitus (DM), the prevalence of DN has since increased significantly due to DM patients having a longer life expectancy. It has been estimated that atleast 50% of DM patients will develop DN in their life, with approximately 20% of these patients experiencing neuropathic pain. Nerves are susceptible to changes in glucose concentrations and insulin makes it impossible for neurons to continue regulating glucose uptake.
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Li, Ting, Shudan Ge, Wei Zheng, Chao Luan, Xingtong Liu, Zongxiu Luo, Qi Zhao, and Lulu Xie. Effectiveness and safety of panretinal photocoagulation combined with intravitreous ranibizumab for patients with type 2 proliferative diabetic retinopathy：A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0048.

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Review question / Objective: Our study aims to synthesise results from randomised controlled trials to assess the effectiveness and safety of PRP combined with intravitreous ranibizumab for T2PDR. Condition being studied: Diabetic retinopathy (DR) is the most common complication of diabetes mellitus, which will seriously affect the quality of life of patients and bring great burden to patients’ families and society. DR is one of the most important diseases of blindness in people aged 20 to 60 years worldwide. Nearly 15% of diabetic patients with a disease duration of more than 5 years were combined with DR.The prevalence of vision threatening diabetic retinopathy in the United States is 4.4 percent. Worldwide, the prevalence is estimated at 10.2%.At present, the treatment methods for type 2 proliferative diabetic retinopathy (T2PDR), at home and abroad mainly include retinal laser photocoagulation and intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors.
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Ferdosian, Hengameh, Hadi Zamanian, Sayed Ali Emami, Elahe Sedighi, Mina Moridi, and Maryam Doustmehraban. Application of artificial intelligence in prediction of cardiovascular complications in patients with diabetes mellitus type 2: A protocol of systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2021. http://dx.doi.org/10.37766/inplasy2021.10.0076.

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Review question / Objective: The aim of this systematic review is to evaluate AI-based models in identifying predictors of cardiovascular events and risk predtion in patients with diabetes mellitus type2. Condition being studied: T2DM patients have an increased risk of macrovascular and microvascular complications, lead to decreased quality of life and mortality. Considering the significance of cardiovascular complications in these patients, prediction of such events would be important. Different traditional statistical methods(such as regression) and new AI-besed algorithms are used to predict these complications in diabetic patients.
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Yan, Huixin, Hongyi Guan, Jiabao Sun, Shaobo Zhang, Haiyu Zhu, Fengyang Wang, and Bailin Song. Therapeutic effect of Chinese Tuina on diabetic peripheral neuropathy: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0037.

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Review question / Objective: Diabetic peripheral neuropathy (DPN) is one of the chronic microvascular complications of diabetes mellitus (DM). Chinese Tuina is a promising external treatment of traditional Chinese medicine (TCM), which can promote blood circulation, increase the support of tissues, accelerate metabolism and facilitate the improvement of neurological function, thereby improving the quality of life of patients with DPN. Although increasing clinical studies reveals the efficacy of Chinese Tuina therapy and its safety on DPN patients, whether Chinese Tuina therapy is indeed improving DPN remains unclear. In this study, we intended to evaluate the clinical efficacy and safety of Chinese Tuina in the treatment of DPN. Patient, Participant, or population: Inclusion criteria: Patients with diabetic peripheral neuropathy (diagnosed clinically using any accepted diagnostic criteria).
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9

Silva, Rodrigo Ribeiro e., Mateus de Miranda Gauza, Julia Opolski Nunes da Silva Opolski, and Maria Eduarda Schramm Guisso. Once-Weekly Insulin Icodec vs Once-Daily Insulin Glargine U100 for Type 2 Diabetes: A Meta-analysis of Phase 2 Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0102.

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Review question / Objective: To compare Once-Weekly Insulin Icodec and Once-Daily Insulin Glargine U100 in patients with Type 2 Diabetes Mellitus using oral hypoglycemic drugs in need of insulin therapy. Condition being studied: Patients with Diabetes Mellitus Type 2 using oral hypoglycemic drugs in need for basal insulin. Eligibility criteria: Inclusion in this meta-analysis was restricted to studies that met all the following criteria: (1) randomized trials; (2) comparing the use once weekly insulin icodec to once daily insulin glargine; (3) enrolling patients with type 1 or type 2 diabetes mellitus; (4) evaluating any of the desired outcomes; (4) articles in written on english language. We excluded studies with (1) no control group; (2) overlapping studies population; clinical trial register entry only; (3) non-human studies and (4) studies reported only as abstracts.
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Sosa Munguía, Paulina del Carmen, Verónica Ajelet Vargaz Guadarrama, Marcial Sánchez Tecuatl, Mario Garcia Carrasco, Francesco Moccia, and Roberto Berra-Romani. Diabetes mellitus alters intracellular calcium homeostasis in vascular endothelial cells: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0104.

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Review question / Objective: What are the effects of diabetes mellitus on the calcium homeostasis in vascular endothelial cells? -To describe the effects of diabetes on the mechanisms that regulate intracellular calcium; -To describe other molecules/mechanisms that alters intracellular Ca2+ homeostasis. Condition being studied: Diabetes mellitus is a pathology with a high incidence in the population, characterized by an increase in blood glucose. People with diabetes are 2-4 times more likely to suffer from a cardiovascular complication, such as total or partial loss of sight, myocardial infarction, kidney failure, among others. Cardiovascular complications have been reported to derive from dysfunction of endothelial cells, which have important functions in blood vessels. In order to understand the etiology of this poor function of endothelial cells, it is necessary to study the molecular mechanisms involved in these functions, to identify the effects of diabetes and thus, develop new research that will mitigate the effects of this pathology.
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