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Dissertations / Theses on the topic 'Diabetes resistance'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

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1

Pickavance, Lucy Cecilia. "Thiazolidinedione treatment in models of insulin resistance." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367553.

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2

Ang, Christine W. M. "Diabetes and the maternal resistance vasculature." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395080.

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3

Hale, P. J. "Insulin resistance in diabetes mellitus and obesity." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371516.

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4

Eason, Robert C. "Treating type 2 diabetes through insulin resistance." Thesis, Aston University, 2002. http://publications.aston.ac.uk/10953/.

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Type 2 diabetes is an insidious disorder, with micro and/or macrovascular and nervous damage occurring in many patients before diagnosis. This damage is caused by hyperglycaemia and the diverse effects of insulin resistance. Obesity, in particular central obesity, is a strong pre-disposing factor for type 2 diabetes. Skeletal muscle is the main site of insulin-stimulated glucose disposal and appears to be the first organ that becomes insulin resistant in the diabetic state, with later involvement of adipose tissue and the liver. This study has investigated the use of novel agents to ameliorate

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5

Reali, Federico. "Dynamical models for diabetes: insights into insulin resistance and type 1 diabetes." Doctoral thesis, Università degli studi di Trento, 2017. https://hdl.handle.net/11572/369184.

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This thesis summarizes my work in systems biology as a PhD student at The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI) and at the University of Trento, department of Mathematics. Systems biology is an interdisciplinary field that aims at integrating biology with computational and mathematical methods to gain a better understanding of biological phenomena [5, 6]. Among these methods, mathematical and dy- namical modeling have driven the discovery of mechanistic insights from the static representations of phenomena, that is, data. As a result, ma

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6

Reali, Federico. "Dynamical models for diabetes: insights into insulin resistance and type 1 diabetes." Doctoral thesis, University of Trento, 2017. http://eprints-phd.biblio.unitn.it/1962/1/Reali_PhDThesis.pdf.

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This thesis summarizes my work in systems biology as a PhD student at The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI) and at the University of Trento, department of Mathematics. Systems biology is an interdisciplinary field that aims at integrating biology with computational and mathematical methods to gain a better understanding of biological phenomena [5, 6]. Among these methods, mathematical and dy- namical modeling have driven the discovery of mechanistic insights from the static representations of phenomena, that is, data. As a result, m

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7

Lindmark, Stina. "Neurohormonal mechanisms in insulin resistance and type 2 diabetes." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-225.

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8

Hunter, Steven J. "Insulin resistance : underlying mechanisms and influence of treatment." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337044.

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9

Relton, Caroline L. "The identification and characterisation of genes associated with insulin resistance." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264425.

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10

Vella, Sandro. "Pharmacological modulation of insulin resistance : benefits and harms." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/4428eca5-5018-4816-95d0-30c0a3043409.

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Aims: Thiazolidinediones have been advocated as second or third line insulin sensitizing agents in the management of type 2 diabetes (T2DM). Their widespread use has been hampered by concerns about their cardiovascular safety, including fluid retention. Metformin is established as first-line glucose-lowering pharmacotherapy in T2DM. It has also been suggested that it may have benefits in alleviating insulin resistance in type 1 diabetes (T1DM). This thesis examined: (i) cardiovascular, renal and metabolic differences between individuals with T2DM ‘tolerant’ or ‘intolerant’ of TZDs; (ii) risk f

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11

Lee, Katie Ting Yan. "Novel wild-derived mouse models of obesity and diabetes resistance." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/41985.

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Novel inbred mouse strains have been developed from wild-caught mice, and they display enhanced genetic diversity compared to the commonly used strains. We hypothesized that their unique genotypes may yield aspects of disease susceptibility previously unobserved in the commonly used strains. We examined two of these strains, PWD/PhJ (PWD) and WSB/EiJ (WSB), for obesity and type 2 diabetes (T2D)-related traits in response to high fat diet (HFD) feeding and compared them to the C57BL/6J (B6) strain. We identified PWD mice as a model of primary hyperinsulinemia. They had increased insulin levels

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12

Marakis, Georgios. "Natural therapy for insulin-resistance syndrome and type II diabetes." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340013.

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13

Järvi, Anette. "Carbohydrate-rich foods in the treatment of the insulin resistance syndrome : studies of the importance of the glycaemic index and dietary fibre /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5166-7/.

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14

Clarke, Stephen. "Liver steatosis and insulin-resistance : reversal by Sutherlandia frutescens." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/d1020788.

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Type 2 diabetes mellitus (T2DM) is rapidly emerging as one of the greatest global health issues of the 21st century. Insulin-resistance is a condition associated with T2DM and in the cell it is defined as the inadequate strength of insulin signalling from the insulin receptor downstream to the final substrates of insulin action involved in multiple metabolic, gene expression, and mitogenic aspects of cellular function. To investigate the potential mechanisms involved in the development of insulin-resistance, two in vitro liver cell models were established using palmitate or a combination of in

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15

Phillips, Amanda S. "The Influence of Perceived Stress on Insulin Resistance in Adults with Type 2 Diabetes." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc699935/.

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Objective: To identify whether perceived stress is a risk-factor for higher cortisol levels and greater insulin resistance in Type 2 diabetic patients, using data from participants with and without diabetes in the National Survey of Midlife Development in the United States (MIDUS), specifically MIDUS II, Project 4. The following hypotheses were tested: (H1a) greater perceived stress would be associated with higher cortisol for Type 2 diabetic participants, (H1b) the perceived stress/cortisol relationship would be stronger for people with Type 2 diabetes than for those without it, (H2) greater

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16

Kershner, David. "Oral Glucose Insulin Secretion Test for Identifying Patients with Insulin Resistance." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5634.

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Insulin resistance is an increasing public health issue with the current literature, suggesting reduced sensitivity of insulin leads to adult onset diabetes and associated downstream pathologies that reduce life expectancy. The main objectives of this study were to evaluate the ability of the Oral Glucose Insulin Secretion Test (OGIST) to identify insulin resistance and examine differences in the insulin sensitivity based on gender, age, and ethnicity. This study was supported by the insulin resistance theory which focuses on the reduced ability of insulin to bind to the cellular insulin recep

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17

Bagstaff, Stephanie M. "Hyperinsulinemia and insulin resistance in cultured human muscle cells." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270177.

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18

Gelcich, Sarah. "Exploring risk, resistance and closing talk in chronic diabetes routine consultations." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19167/.

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Qualitative research is widely recognised as making a valuable contribution to healthcare practice and policy. One area of study that has noticeably relied on qualitative research is doctor-patient communication, due to the fact that practitioner-patient interaction is inherently dependent on talk. One methodology that has proven very useful in order to analyse practitioner-patient interaction is Conversation Analysis (CA). Little seems to have been done in terms of analysing practitioner-patient talk within chronic routine consultations. Routine consultations are especially important in the t

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19

Fryer, Lee George Daniel. "Studies into the role of glucose transporter function in insulin resistance." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265007.

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20

Crawford, Lynne Mary. "The regulation of triglyceride metabolism in the liver and adipose tissue." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263457.

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21

Ranasinghe, Dilip Chathuranga. "The effects of supervised aerobic and resistance exercise training on Sri Lankan adults with type 2 diabetes mellitus: Sri Lanka diabetes aerobic and resistance training (SL-DART) study." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/115457/1/115457_9304177_ranasinghe_dilip_chathuranga_thesis.pdf.

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This study had 2 components investigating the effects of exercise in Sri Lankan adults with type 2 diabetes mellitus (T2DM). The quantitative component consisted of a 12 week randomized controlled trial comparing aerobic training, resistance training and usual care on glycaemic control (HBA1C), % body fat and range of clinically important endpoints. The qualitative component consisted of in-depth interviews to determine barriers/facilitators for adherence to different modes of exercise. The study proved, despite cultural challenges and barriers, the possibility of conducting a large-scale exer

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22

Andrews, Tara Jane. "The role of endothelial function and oxidant stress in a model of insulin resistance." Thesis, Queen Mary, University of London, 2003. http://qmro.qmul.ac.uk/xmlui/handle/123456789/28587.

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Type 2 diabetes mellitus affects over 100 million people worldwide. It is characterized by various metabolic abnormalities such as insulin resistance, aberrant insulin secretion, hyperglycaemia and a cluster of cardiovascular risk factors, including increased oxidative stress. It is associated with microvascular complications and increased potential of macrovascular disease. The aim of the studies described in this thesis was to test the hypothesis that oxidant stress contributes to an altered vascular function and impaired insulin regulation in a pre-diabetic animal model- the obese Zucker ra

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23

McClean, Paula. "Inhibition of GIP signalling alleviates obesity, insulin resistance and type 2 diabetes." Thesis, University of Ulster, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494369.

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24

Wiggam, Malcolm Ivan. "Aspects of insulin resistance in essential hypertension and insulin-dependent diabetes mellitus." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387971.

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25

Cairncross, Joy Claudia. "The effect of 14 weeks of strength training on insulin resistance." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d1018276.

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Insulin resistance is a precursor to type II diabetes mellitus and in conjunction with dyslipidaemia, hypertension, and obesity, these abnormalities constitute the metabolic syndrome. Insulin resistance usually develops before these other diseases and therefore identifying and successfully treating insulin resistant patients may have potentially great preventive value. Insulin resistance, obesity, and subsequently type II diabetes mellitus have increased dramatically and have reached epidemic proportions. The incidence of diabetes, and in particular type II diabetes mellitus, is increasing in

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26

Jun, Lucy Soo Yon. "Thyroid hormone-regulated skeletal muscle Glut4 glucose transporter trafficking during fasting in diet-induced obesity and insulin resistance." CSUSB ScholarWorks, 2005. https://scholarworks.lib.csusb.edu/etd-project/2869.

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This thesis project will investigate the effects of fasting on the serum levels of two key regulatory hormones, insulin and thyroid hormone (T3) and the effects of these hormones on the trafficking of Glut4 on soleus muscle.

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27

Kuhl, Jeanette. "Pathogenesis of type 2 diabetes with emphasis on the mechanism of insulin resistance /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-839-8/.

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28

Stone, Monique Lee Women's &amp Children's Health Faculty of Medicine UNSW. "Poor glycaemic control in adolescents with type 1 diabetes." Publisher:University of New South Wales. Women's & Children's Health, 2008. http://handle.unsw.edu.au/1959.4/41281.

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Many adolescents with type 1 diabetes (T1DM) have suboptimal glycaemic control, increasing the risk of diabetic complications. This thesis explores some of the causes, consequences and therapeutic options for adolescents with T1DM and poor glycaemic control. Insulin resistance occurs in T1DM and normal puberty and contributes to poor glycaemic control. The effect of rosiglitazone, an insulin sensitizer, in addition to insulin on the glycaemic control of adolescents with T1DM was tested using a randomized, double blind placebo controlled trial. Treatment with rosiglitazone did not improve HbA

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29

Erickson, Andrea Rose. "The Association Between Dairy Consumption and Insulin Resistance." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4262.

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Background: A cross-sectional design was employed to ascertain the relationship between dairy consumption and insulin resistance (IR) in 272 middle-aged, nondiabetic women. Methods: Participants kept a seven-day weighed food record to report their diets, including consumption of dairy foods. IR was assessed using the homeostatic model assessment (HOMA), using the following formula: fasting plasma insulin (µU/ml) x fasting plasma glucose (mg/dL)/405. The Bod Pod was used to examine body fat percentage, and accelerometry over a seven-day period was used to assess physical activity. HOMA values w

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30

Winnick, Jason Joseph. "Effect of aerobic exercise on peripheral glucose uptake and endogenous glucose production in type 2 diabetes mellitus." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1157551296.

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31

Ng, Foong Loo Yvonne Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Insulin action: unravelling AKT signalling in Adipocytes." Awarded by:University of New South Wales. Biotechnology & Biomolecular Sciences, 2009. http://handle.unsw.edu.au/1959.4/44628.

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The Ser/Thr kinase Akt plays an important role in many of insulin's actions including GLUT4 translocation to the plasma membrane (PM). However, there are several features of Akt's regulation of GLUT4 translocation that remain unclear. The goal of my thesis was to resolve some of the following questions: Is activation of Akt sufficient to stimulate GLUT4 translocation? What is the quantitative relationship in signal transmission between individual components within the Akt cascade? What is the role of Akt in insulin resistance? To determine if activation of Akt is sufficient to mediate GLUT4 tr

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32

Moncrieft, Ashley E. "Inactivity, Inflammation, and Insulin Resistance in Type 2 Diabetes and the Metabolic Syndrome." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_theses/300.

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Both type 2 diabetes (T2D) and the the metabolic syndrome (MetS) have been shown to increase the risk of cardiovascular disease (CVD). Inflammation and insulin resistance have each been associated with the development of MetS and the onset of T2D as well as the risk of CVD. Inflammation and insulin resistance are therefore suitable targets for public health initiatives and interventions in persons at risk for or living with CVD. Physical inactivity is a major risk factor for CVD as well as MetS and T2D. Conversely, increased physical activity is associated with improved health outcomes for in

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33

Song, Xiao Mei. "Insulin signal transduction in skeletal muscle : special consideration for insulin resistance and diabetes /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4502-0/.

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34

Danielsson, Anna. "Insulin signalling in human adipocytes : mechanisms of insulin resistance in type 2 diabetes." Doctoral thesis, Linköping : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-10327.

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35

Puthanveetil, Prasanth Nair. "Role of cardiac FoxO1 in conditions of insulin resistance, nutrient excess, and diabetes." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/41051.

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Glucocorticoids increase PDK4 mRNA and protein expression, which phosphorylates PDH, thereby preventing the formed pyruvate from undergoing mitochondrial oxidation. This increase in PDK4 expression is mediated by the mandatory presence of FoxOs in the nucleus. Rat cardiomyocytes exposed to Dx produced a robust decrease in glucose oxidation. Measurement of FoxO compartmentalization demonstrated increase in nuclear, but resultant decrease in cytosolic content of FoxO1 with no change in the total content. The increase in nuclear content of FoxO1 correlated to an increase in nuclear phospho p3

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36

Platt, Thomas. "LEPTIN RESISTANCE INDUCED OBESITY AND DIABETES PROMOTE NEUROPATHOLOGICAL CHANGES IN THE AGING BRAIN." UKnowledge, 2014. http://uknowledge.uky.edu/biochem_etds/18.

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The aging brain is prone to the development of pathology and dementia. With a rapidly growing elderly population diagnoses of neurodegenerative diseases, such as Alzheimer’s disease (AD), frontotemporal dementia (FTD), and Parkinson’s disease are on the rise. Additionally, diabetes and obesity are linked to an increased risk of dementia. The convergence of this increasingly aged population with the obesity and diabetes epidemic give rise to new concerns regarding the future of prevention and treatment of neurodegenerative diseases. Our lab has previously shown that leptin, an adipokine involve

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37

Turner, Daniel. "Impact of acute resistance exercise on glycaemia in individuals with type 1 diabetes." Thesis, Swansea University, 2015. https://cronfa.swan.ac.uk/Record/cronfa43149.

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The impact of acute resistance exercise (RE) on glycaemia in type 1 diabetes (T1DM) individuals is poorly understood. Yet, such knowledge would have great use in improving our understanding of blood glucose control during and after the performance of RE. Increasing research in this area might help minimise complications associated with blood glucose vulnerability and potentially maximise health benefits related to RE which are known to be obtained by people without diabetes. The overarching aim of this thesis was to examine the impact of acute RE on glycaemia in T1DM individuals, and promote c

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38

Kudiarasu, Christine. "Effects of eccentric versus concentric resistance training in adults with Type 2 Diabetes." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2020. https://ro.ecu.edu.au/theses/2297.

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The benefits of resistance training for people with Type 2 diabetes (T2D) are well documented; however, the effects of different muscle contraction types (e.g. eccentric, concentric) on physiological outcomes for this population are still unclear. This study investigated the effects of eccentric (ECC) versus concentric (CON) resistance training on blood markers, muscle strength, physical functional performance and body composition. Eighteen adults with T2D (Age: 64.8 ± 9.0 y; BMI: 30.3 ± 4.1 kg/m2) were randomly assigned to either an ECC (n = 9) or a CON (n = 9) group. Participants performed 2

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39

Frangioudakis, Georgia St Vincent's Clinical School UNSW. "Insulin signal transduction in vivo in states of lipid-induced insulin resistance." Awarded by:University of New South Wales. St Vincent's Clinical School, 2004. http://handle.unsw.edu.au/1959.4/27419.

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Insulin resistance is the major metabolic defect in obesity and Type 2 diabetes. Increased lipid accumulation is strongly associated with insulin resistance. A significant component of insulin resistance is thought to be a reduced ability of insulin to activate the cascade of phosphorylation events that lead to the metabolic effects of this hormone. The broad aims of this thesis were to examine the effect of high-fat diets containing different fat subtypes on in vivo insulin signalling, under conditions normally used to detect whole body insulin resistance, and to compare the effects of acute

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40

Sharma, Divya. "Drug Delivery Systems for Treatment of Diabetes Mellitus." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/31745.

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Daily injections for basal insulin therapy are far from ideal resulting in hypo/hyperglycemic episodes associated with fatal complications in type-1 diabetes patients. The purpose of this study was to develop a thermosensitive copolymer-based in situ depot forming delivery system to provide controlled release of insulin for extended duration following a single subcutaneous injection, closely mimicking physiological basal insulin requirement. Size and nature of the incorporated therapeutic were observed to affect the release profile of insulin. Modification with zinc and chitosan preserved ther

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41

McConnell, Elizabeth Mae. "Increased vascular disease in adult hypopituitarism : studies of mortality, insulin resistance and endothelial function." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301743.

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42

Talbot, Nicola A. "Obesity, inflammation and insulin resistance in skeletal muscle." Thesis, Royal Veterinary College (University of London), 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618327.

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43

Andersen, Ditte K. "The role of microRNAs in skeletal muscle insulin resistance." Thesis, Royal Veterinary College (University of London), 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701676.

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44

Nowak, Christoph. "Insulin Resistance : Causes, biomarkers and consequences." Doctoral thesis, Uppsala universitet, Molekylär epidemiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316891.

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The worldwide increasing number of persons affected by largely preventable diseases like diabetes demands better prevention and treatment. Insulin is required for effective utilisation of circulating nutrients. Impaired responsiveness to insulin (insulin resistance, IR) is a hallmark of type 2 diabetes and independently raises the risk of heart attack and stroke. The pathophysiology of IR is incompletely understood. High-throughput measurement of large numbers of circulating biomarkers may provide new insights beyond established risk factors. The aims of this thesis were to (i) use proteomics,

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45

Alkhalidy, Hana Awwad. "Flavonol kaempferol in the regulation of glucose homeostasis in diabetes." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/82485.

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Diabetes mellitus is a major public health concern. Although the accessible novel drugs, techniques, and surgical intervention has improved the survival rate of individuals with diabetes, the prevalence of diabetes is still rising. Type 2 diabetes (T2D) is a result of chronic insulin resistance (IR) and loss of β-cell mass and function. Therefore, the search for naturally occurring, low-cost, and safe compounds that could enhance insulin sensitivity and protect functional β-cell mass can be an effective strategy to prevent this disease. Kaempferol, a flavonol present in various medic

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46

Negrato, Carlos Antonio [UNESP]. "Hiperglicemia gestacional leve como fator de risco para síndrome metabólica na gravidez e morbilidade perinatal." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/104174.

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Made available in DSpace on 2014-06-11T19:32:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-10-20Bitstream added on 2014-06-13T18:44:46Z : No. of bitstreams: 1 negrato_ca_dr_botfm_prot.pdf: 898163 bytes, checksum: a56403a143501d6e1f412e9ff5d74684 (MD5)<br>Fundação para o Desenvolvimento Médico e Hospitalar (Famesp)<br>Em 1988, Reaven descreveu a síndrome X, uma junção de diversos fatores de risco para as doenças cardiovasculares, sendo a resistência à insulina o ponto de partida para o estabelecimento de tais fatores. Várias denominações foram dadas a este grupo de comorbidades e

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47

Dumais, Valerie. "Insulin Resistance, Metabolic Syndrome and Diabetes in Women at High Risk for Breast Cancer." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31508.

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Purpose: The overall objective of this prospective study was to quantify the prevalence of insulin resistance (IR), metabolic syndrome (MetS) and type 2 diabetes (T2D) in women at high risk for breast cancer, stratified by menopausal status. We also aimed to calculate the sample size required for a future case-control study comparing these prevalences to those of the general population. Methods: Participants consisted of 100 Caucasian women above the age of 35 with an estimated 5yr risk of breast cancer ≥1.7%. A comprehensive metabolic profile was obtained for each participant based on a ques

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48

Mårdberg, Emelie. "Effect of Resistance Training in Patients with Type 2 Diabetes Mellitus : − A Systematic Review." Thesis, Örebro universitet, Institutionen för läkarutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-37001.

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49

Agbaje, Olorunsola Fatai. "Modelling methodologies to assess insulin resistance and insulin secretion in type 2 diabetes subjects." Thesis, City University London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397933.

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50

Direk, Kenan. "The role of mitochondria in the development of insulin resistance and type 2 diabetes." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-mitochondria-in-the-development-of-insulin-resistance-and-type-2-diabetes(30f426ed-9221-473f-b177-acefda85acaa).html.

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This thesis explores three broad areas of interest in the pathophysiology of type 2 diabetes (T2D). The first part of the thesis examines the relative contributions of body fat measurements on T2D and related morbidities in a large cohort of twins. A proxy measure of visceral fat was constructed from anthropometric and dual-energy X-ray absorptiometry, its heritability was estimated at 58% using the classical twin model and its influence on morbidity was compared to total abdominal fat and the body mass index. The findings from this work show that intra-abdominal adiposity confers the greatest

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