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Journal articles on the topic 'Diabetes reversal'

Author: Grafiati

Published: 3 June 2025

Last updated: 1 August 2025

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1

Aguiar, Monique Maria Lucena Suruagy do Amaral, and Rosana de Araújo Bezouro Soares. "DIABETES REVERSAL - TYPE 2." International Journal of Health Science 2, no. 18 (2022): 2–7. http://dx.doi.org/10.22533/at.ed.1592182201041.

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2

Dhangar, Sanjay Prakash. "The truth of diabetes reversal." Journal of International Medical Research and Health Sciences 01, no. 02 (2021): 01–06. http://dx.doi.org/10.53626/jimrhs.2021.1201.

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3

Hallberg, Sarah J., Victoria M. Gershuni, Tamara L. Hazbun, and Shaminie J. Athinarayanan. "Reversing Type 2 Diabetes: A Narrative Review of the Evidence." Nutrients 11, no. 4 (2019): 766. http://dx.doi.org/10.3390/nu11040766.

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Background: Type 2 diabetes (T2D) has long been identified as an incurable chronic disease based on traditional means of treatment. Research now exists that suggests reversal is possible through other means that have only recently been embraced in the guidelines. This narrative review examines the evidence for T2D reversal using each of the three methods, including advantages and limitations for each. Methods: A literature search was performed, and a total of 99 original articles containing information pertaining to diabetes reversal or remission were included. Results: Evidence exists that T2

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4

WALSH, NANCY. "Gastric Bypass: Diabetes Reversal Almost Universal." Family Practice News 35, no. 9 (2005): 23. http://dx.doi.org/10.1016/s0300-7073(05)70642-3.

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5

Simeonovic, C. J., S. J. Prowse, and K. J. Lafferty. "Reversal of diabetes in outbred mice by islet allotransplantation." Diabetes 35, no. 12 (1986): 1345–49. http://dx.doi.org/10.2337/diabetes.35.12.1345.

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6

Singh, Ruchi. "Reversing type 2 diabetes: journal review and a case study." Advances in Obesity, Weight Management & Control 10, no. 5 (2020): 163–67. http://dx.doi.org/10.15406/aowmc.2020.10.00322.

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Type 2 diabetes (T2D) has for quite some time been recognized as a serious interminable malady dependent on conventional methods for treatment. Exploration currently exists that proposes reversal is conceivable through different implies that have as of late been grasped in the rules. This account audit looks at the proof for T2D reversal utilizing every one of the three strategies, including points of interest and constraints for each. Techniques: A research was performed, and an aggregate of unique articles containing data relating to diabetes reversal or abatement were incorporated. Results:

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7

McLane, M. P., P. R. Black, W. R. Law, and R. M. Raymond. "Adenosine reversal of in vivo hepatic responsiveness to insulin." Diabetes 39, no. 1 (1990): 62–69. http://dx.doi.org/10.2337/diabetes.39.1.62.

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8

Beyer-Mears, A., and E. Cruz. "Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor." Diabetes 34, no. 1 (1985): 15–21. http://dx.doi.org/10.2337/diabetes.34.1.15.

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9

Greco, A. V., G. Mingrone, A. Giancaterini, et al. "Insulin Resistance in Morbid Obesity: Reversal With Intramyocellular Fat Depletion." Diabetes 51, no. 1 (2002): 144–51. http://dx.doi.org/10.2337/diabetes.51.1.144.

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10

Piferrer, Francesc, and Dafni Anastasiadi. "Do the Offspring of Sex Reversals Have Higher Sensitivity to Environmental Perturbations?" Sexual Development 15, no. 1-3 (2021): 134–47. http://dx.doi.org/10.1159/000515192.

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Sex determination systems in vertebrates vary along a continuum from genetic (GSD) to environmental sex determination (ESD). Individuals that show a sexual phenotype opposite to their genotypic sex are called sex reversals. Aside from genetic elements, temperature, sex steroids, and exogenous chemicals are common factors triggering sex reversal, a phenomenon that may occur even in strict GSD species. In this paper, we review the literature on instances of sex reversal in fish, amphibians, reptiles, birds, and mammals. We focus on the offspring of sex-reversed parents in the instances that they

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11

TUCH, B. E. "REVERSAL OF DIABETES BY HUMAN FETAL PANCREAS." TRANSPLANTATION 51, no. 3 (1991): 557–61. http://dx.doi.org/10.1097/00007890-199103000-00002.

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12

Melton, Douglas A. "Reversal of Type 1 Diabetes in Mice." New England Journal of Medicine 355, no. 1 (2006): 89–90. http://dx.doi.org/10.1056/nejmcibr062559.

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13

Faustman, D. L. "Permanent Reversal of Diabetes in NOD Mice." Science 317, no. 5835 (2007): 196a. http://dx.doi.org/10.1126/science.317.5835.196a.

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14

Faustman, Denise L. "Reversal of Type 1 Diabetes in Mice." New England Journal of Medicine 356, no. 3 (2007): 311–12. http://dx.doi.org/10.1056/nejmc062066.

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15

Prasad, G. Surendra. "Diabetes reversal: Hope, hype, and the real." Medicover Journal of Medicine 2, no. 1 (2025): 1–3. https://doi.org/10.4103/mjm.mjm_9_25.

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16

van der Sloot, Paul, Andrew Mizisin, and Douglas Zochodne. "Sulindac in Established Experimental Diabetes: a Follow-up Study." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 22, no. 3 (1995): 198–201. http://dx.doi.org/10.1017/s0317167100039846.

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AbstractBackgroundIn two previous studies we have demonstrated prevention of electrophysiological abnormalities of nerve in experimental STZ (streptozotocin)-induced diabetes (ED) of rats using nonsteroidal anti-inflammatory agents: indomethacin and sulindac. Sulindac might benefit ED because it inhibits both cyclo-oxygenase and aldose reductase.MethodsIn this work, we examined whether 1 month of sulindac treatment reversed or improved established biochemical and electrophysiological abnormalities in experimental diabetes of 3 months duration. Sulindac-treated diabetic rats (6.0 mg/kg 5/7 days

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17

Dagogo-Jack, S., C. Rattarasarn, and P. E. Cryer. "Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM." Diabetes 43, no. 12 (1994): 1426–34. http://dx.doi.org/10.2337/diabetes.43.12.1426.

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18

Pieper, G. M., M. Jordan, L. A. Dondlinger, M. B. Adams, and A. M. Roza. "Peroxidative stress in diabetic blood vessels. Reversal by pancreatic islet transplantation." Diabetes 44, no. 8 (1995): 884–89. http://dx.doi.org/10.2337/diabetes.44.8.884.

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19

Lagger, Grégoire, Jorge Cesar Correia, Peter Fernandes, Frédéric Sittarame, and Alain Golay. "A 5-dimension patient education program targeting type 2 diabetes remission." Education Thérapeutique du Patient - Therapeutic Patient Education 10, no. 2 (2018): 20206. http://dx.doi.org/10.1051/tpe/2018018.

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Introduction: Type 2 diabetes (T2D) reversal has been demonstrated in patients undergoing bariatric surgery or low caloric diets. Objective: To investigate the effects of therapeutic patient education alone on T2D reversal in early diagnosed patients. Methods: Seventeen T2D patients underwent a one-week therapeutic education program, followed by 12 months of 1 hour sessions every month, targeting diabetes reversal. This reversal was determined using the DiaRem score which integrates glycated hemoglobin levels and antidiabetic drug treatment. Patient’s conceptions, perceptions and motivation we

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20

Vatarescu, Maayan, Sapir Bechor, Yulia Haim, et al. "Adipose tissue supports normalization of macrophage and liver lipid handling in obesity reversal." Journal of Endocrinology 233, no. 3 (2017): 293–305. http://dx.doi.org/10.1530/joe-17-0007.

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Adipose tissue inflammation and dysfunction are considered central in the pathogenesis of obesity-related dysmetabolism, but their role in the rapid metabolic recovery upon obesity reversal is less well defined. We hypothesized that changes in adipose tissue endocrine and paracrine mechanisms may support the rapid improvement of obesity-induced impairment in cellular lipid handling. C57Bl-6J mice were fed ad libitum either normal chow (NC) or high-fat diet (HFF) for 10 weeks. A dietary obesity reversal group was fed HFF for 8 weeks and then switched to NC for 2 weeks (HFF→NC). Whole-body gluco

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21

Imam, Shahnawaz, Alexa Jaume, and Juan Jaume. "PSUN231 Adoptive Cell Transfer for Type 1 Diabetes Reversal." Journal of the Endocrine Society 6, Supplement_1 (2022): A385—A386. http://dx.doi.org/10.1210/jendso/bvac150.802.

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Abstract We have discovered a way to cure type 1 diabetes in a mouse model that closely resembles the human disease. Specifically, we are able to genetically modify blood cells from affected individuals and re-infuse them back to rescue insulin-producing beta cells being destroyed by the immune system.When autoimmune diabetes affects the youth, it is known as Juvenile or type 1 diabetes (T1D). It is named Latent Autoimmune Diabetes of Adults (LADA) when it affects adults. T1D affects about 1 million people in the USA. LADA is estimated to affect at least 10% of the type 2 diabetes population (

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22

Kin, T., G. S. Korbutt, T. Kobayashi, J. M. Dufour, and R. V. Rajotte. "Reversal of Diabetes in Pancreatectomized Pigs After Transplantation of Neonatal Porcine Islets." Diabetes 54, no. 4 (2005): 1032–39. http://dx.doi.org/10.2337/diabetes.54.4.1032.

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23

Fan, M. Y., Z. P. Lum, X. W. Fu, L. Levesque, I. T. Tai, and A. M. Sun. "Reversal of diabetes in BB rats by transplantation of encapsulated pancreatic islets." Diabetes 39, no. 4 (1990): 519–22. http://dx.doi.org/10.2337/diabetes.39.4.519.

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24

Sallar, Anthony, and Samuel Dagogo-Jack. "Regression from prediabetes to normal glucose regulation: State of the science." Experimental Biology and Medicine 245, no. 10 (2020): 889–96. http://dx.doi.org/10.1177/1535370220915644.

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Prediabetes, an intermediate stage between normal glucose regulation and type 2 diabetes, is diagnosed based on documentation of impaired fasting glucose, impaired glucose tolerance, or a hemoglobin A1c level of 5.7–6.4%. Individuals with prediabetes have increased risks for the development of type 2 diabetes and multiple vascular complications. Randomized controlled trials have demonstrated the feasibility of preventing progression from prediabetes to type 2 diabetes, using lifestyle or pharmacological interventions. Lifestyle modification has a sustained effect on diabetes prevention, wherea

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25

Patel, Jatin, Nur Azim Matnor, Abishek Iyer та Lindsay Brown. "A Regenerative Antioxidant Protocol of Vitamin E andα-Lipoic Acid Ameliorates Cardiovascular and Metabolic Changes in Fructose-Fed Rats". Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/120801.

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Type 2 diabetes is a major cause of cardiovascular disease. We have determined whether the metabolic and cardiovascular changes induced by a diet high in fructose in young adult male Wistar rats could be prevented or reversed by chronic intervention with natural antioxidants. We administered a regenerative antioxidant protocol using two natural compounds:α-lipoic acid together with vitamin E (α-tocopherol alone or a tocotrienol-rich fraction), given as either a prevention or reversal protocol in the food. These rats developed glucose intolerance, hypertension, and increased collagen deposition

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26

Desai, Shivani, Shubhangi Buchade, Sohan Chitlange, et al. "Vaccines For Type 1 Diabetes: Prevention or Reversal?" Current Diabetes Reviews 17, no. 1 (2020): 30–36. http://dx.doi.org/10.2174/1573399816666200330145501.

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Type 1 diabetes mellitus (T1DM) is an autoimmune disease which leads to the destruction of pancreatic &#946;-cells, thereby causing insufficient insulin production. Globally, around 98, 200 children and adolescents below 15 years of age and almost 128,900 subjects below 20 years of age develop T1DM annually, along with severe complications deteriorating their quality of life. In India alone, around 15,900 incident cases below 15 years have reported annually. Hence, its prevention and reversal are significant. Unlike other chronic diseases, T1DM involves the presence of various autoantigens

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27

Schillaci, Giuseppe, Matteo Pirro, and Elmo Mannarino. "Left Ventricular Hypertrophy Reversal and Prevention of Diabetes." Hypertension 50, no. 5 (2007): 851–53. http://dx.doi.org/10.1161/hypertensionaha.107.099747.

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28

Taylor, Roy. "Calorie restriction and reversal of type 2 diabetes." Expert Review of Endocrinology & Metabolism 11, no. 6 (2016): 521–28. http://dx.doi.org/10.1080/17446651.2016.1239525.

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29

Seppa, Nathan. "Bariatric reversal: Stomach surgery curbs some patients' diabetes." Science News 173, no. 4 (2009): 54. http://dx.doi.org/10.1002/scin.2008.5591730408.

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30

Liu, X. M., K. F. Federlin, R. G. Bretzel, B. J. Hering, and M. D. Brendel. "Persistent reversal of diabetes by transplantation of fetal pig proislets into nude mice." Diabetes 40, no. 7 (1991): 858–66. http://dx.doi.org/10.2337/diabetes.40.7.858.

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31

Sidhoum, Valerie F., Yee-Ming Chan, Margaret F. Lippincott, et al. "Reversal and Relapse of Hypogonadotropic Hypogonadism: Resilience and Fragility of the Reproductive Neuroendocrine System." Journal of Clinical Endocrinology & Metabolism 99, no. 3 (2014): 861–70. http://dx.doi.org/10.1210/jc.2013-2809.

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Context: A subset of patients diagnosed with idiopathic hypogonadotropic hypogonadism (IHH) later achieves activation of their hypothalamic-pituitary-gonadal axis with normalization of steroidogenesis and/or gametogenesis, a phenomenon termed reversal. Objective: The objective of this study was to determine the natural history of reversal and to identify associated phenotypes and genotypes. Design, Setting, and Subjects: This was a retrospective review of clinical, biochemical, and genetic features of patients with IHH evaluated at an academic medical center. Main Outcome Measures: History of

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32

Hayashi, Takuma. "Pancreatic β-Cells Regeneration During the Reversal of Autoimmune Diabetes in Nod Mice." Indian Journal of Applied Research 4, № 3 (2011): 387–88. http://dx.doi.org/10.15373/2249555x/mar2014/121.

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33

Orloff, M. J., N. Yamanaka, G. E. Greenleaf, Y. T. Huang, D. G. Huang, and X. S. Leng. "Reversal of mesangial enlargement in rats with long-standing diabetes by whole pancreas transplantation." Diabetes 35, no. 3 (1986): 347–54. http://dx.doi.org/10.2337/diabetes.35.3.347.

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34

Stackhouse, S., P. L. Miller, S. K. Park, and T. W. Meyer. "Reversal of glomerular hyperfiltration and renal hypertrophy by blood glucose normalization in diabetic rats." Diabetes 39, no. 8 (1990): 989–95. http://dx.doi.org/10.2337/diabetes.39.8.989.

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35

Lum, Z. P., I. T. Tai, M. Krestow, J. Norton, I. Vacek, and A. M. Sun. "Prolonged reversal of diabetic state in NOD mice by xenografts of microencapsulated rat islets." Diabetes 40, no. 11 (1991): 1511–16. http://dx.doi.org/10.2337/diabetes.40.11.1511.

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36

Nikolic, B., Y. Takeuchi, I. Leykin, Y. Fudaba, R. N. Smith, and M. Sykes. "Mixed Hematopoietic Chimerism Allows Cure of Autoimmune Diabetes Through Allogeneic Tolerance and Reversal of Autoimmunity." Diabetes 53, no. 2 (2004): 376–83. http://dx.doi.org/10.2337/diabetes.53.2.376.

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37

Burstein, R., C. Polychronakos, C. J. Toews, J. D. MacDougall, H. J. Guyda, and B. I. Posner. "Acute reversal of the enhanced insulin action in trained athletes. Association with insulin receptor changes." Diabetes 34, no. 8 (1985): 756–60. http://dx.doi.org/10.2337/diabetes.34.8.756.

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38

Manco, Melania, Laura Leccesi, and Geltrude Mingrone. "Reversal of Diabetes and Metabolic Disorders After Bariatric Surgery." Current Nutrition & Food Science 3, no. 2 (2007): 145–50. http://dx.doi.org/10.2174/157340107780598708.

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39

Kochman, Alan B., Dale H. Carnegie, and Thomas J. Burke. "Symptomatic Reversal of Peripheral Neuropathy in Patients with Diabetes." Journal of the American Podiatric Medical Association 92, no. 3 (2002): 125–30. http://dx.doi.org/10.7547/87507315-92-3-125.

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Forty-nine consecutive subjects with established diabetic peripheral neuropathy were treated with monochromatic near-infrared photo energy (MIRE) to determine if there was an improvement of sensation. Loss of protective sensation characterized by Semmes-Weinstein monofilament values of 4.56 and above was present in 100% of subjects (range, 4.56 to 6.45), and 42 subjects (86%) had Semmes-Weinstein values of 5.07 or higher. The ability to discriminate between hot and cold sensation was absent (54%) or impaired (46%) in both groups prior to the initiation of MIRE treatment. On the basis of Semmes

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40

Dagogo-Jack, S., C. G. Fanelli, and P. E. Cryer. "Durable reversal of hypoglycemia unawareness in type 1 diabetes." Diabetes Care 22, no. 5 (1999): 866–67. http://dx.doi.org/10.2337/diacare.22.5.866.

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41

Simeonovic, C. J., S. J. Prowse, and K. J. Lafferty. "Reversal of Diabetes in Outbred Mice by Islet Allotransplantation." Diabetes 35, no. 12 (1986): 1345–49. http://dx.doi.org/10.2337/diab.35.12.1345.

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42

Keidar, A. "Bariatric Surgery for Type 2 Diabetes Reversal: The Risks." Diabetes Care 34, Supplement_2 (2011): S361—S266. http://dx.doi.org/10.2337/dc11-s254.

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43

FAUSTMAN, DENISE L. "Reversal of Established Autoimmune Diabetes byin Situβ-Cell Regeneration". Annals of the New York Academy of Sciences 961, № 1 (2002): 40. http://dx.doi.org/10.1111/j.1749-6632.2002.tb03043.x.

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44

Chowdhury, Dr Biswaroop Roy. "Reversal of type 1 diabetes by plant based diet." International Journal of Diabetes Research 6, no. 1 (2024): 40–54. http://dx.doi.org/10.33545/26648822.2024.v6.i1a.16.

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45

Ravina, A., L. Slezak, N. Mirsky, N. A. Bryden, and R. A. Anderson. "Reversal of corticosteroid-induced diabetes mellitis with supplemental chromium." Diabetic Medicine 16, no. 2 (1999): 164–67. http://dx.doi.org/10.1046/j.1464-5491.1999.00004.x.

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46

Taylor, Roy, Ahmad Al-Mrabeh, and Naveed Sattar. "Understanding the mechanisms of reversal of type 2 diabetes." Lancet Diabetes & Endocrinology 7, no. 9 (2019): 726–36. http://dx.doi.org/10.1016/s2213-8587(19)30076-2.

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47

YANG. "Reversal of diabetes in rodents by encapsulated fish islets." Cell Transplantation 5, no. 5 (1996): 53. http://dx.doi.org/10.1016/0963-6897(96)82234-2.

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48

Banerjee, Meenal, Anil Kumar, and Ramesh R. Bhonde. "Reversal of experimental diabetes by multiple bone marrow transplantation." Biochemical and Biophysical Research Communications 328, no. 1 (2005): 318–25. http://dx.doi.org/10.1016/j.bbrc.2004.12.176.

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49

Fauza, Dario O. "Reversal of Type 1 diabetes mellitus without exogenous cells." Regenerative Medicine 1, no. 4 (2006): 485–88. http://dx.doi.org/10.2217/17460751.1.4.485.

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50

Joshi, Shivam, Timothy Zaki, Robert J. Ostfeld, and Michelle McMacken. "Utility of Unrefined Carbohydrates in Type 2 Diabetes. Comment on “Reversing Type 2 Diabetes: A Narrative Review of the Evidence, Nutrients, 2019, 11, 766”." Nutrients 11, no. 7 (2019): 1620. http://dx.doi.org/10.3390/nu11071620.

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